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Dissertations / Theses on the topic 'Glycans'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Bharate, Priya [Verfasser]. "Automated Glycan Assembly of Oligomannose Glycans for Sensing Applications / Priya Bharate." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1147758336/34.

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2

Llop, Escorihuela Esther. "Structural analysis of eythropoietin glycans." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7129.

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La eritropoyetina o EPO es una hormona glicoproteica. En los seres humanos adultos, se produce principalmente en el riñón, en respuesta a la reducción de oxígeno en los tejidos (hipoxia tisular). La EPO estimula la eritropoyesis, es decir, estimula a las células madre de la médula ósea para que aumenten la producción de eritrocitos. La molécula de EPO está formada por una cadena peptídica de 165 aminoácidos que contiene dos puentes disulfuro, un O-glicano (Ser-126), y tres N-glicanos (Asn-24, 38, 83). En conjunto, la glicosilación de esta proteína representa aproximadamente el 40% del peso tot

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3

Jaworek, Christine H. "Synthesis of inositol phosphate glycans /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2000.

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Thesis (Ph.D.)--Tufts University, 2000.<br>Adviser: Marc d'Alarcao. Submitted to the Dept. of Chemistry. Includes bibliographical references (leaves 262-271). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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4

Wilson, Katherine. "The role of glycans in osteogenesis." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/10403/.

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Glycosylation is an abundant post translational modification of proteins, which occurs in the endoplasmic reticulum and Golgi. Nearly every secreted and plasma membrane localised protein is glycosylated. Mesenchymal stromal/stem cells (MSCs) are adult stem cells that can self-renew and differentiate into multiple cell types including: osteoblasts, adipocytes and chondrocytes. Due to their tri-lineage capacity and their immunoregulatory functions, MSCs are attractive tools for the treatment of multiple diseases and conditions. Key to their use in regenerative medicine is knowledge about what in

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5

Berry, Eric Zachary 1980. "Bioinformatics and database tools for glycans." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/27085.

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Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.<br>Includes bibliographical references (leaves 75-76).<br>Recent advances in biology have afforded scientists with the knowledge that polysaccharides play an active role in modulating cellular activities. Glycosaminoglycans (GAGs) are one such family of polysaccharides that play a very important role in regulating the functions of numerous important signaling molecules and enzymes in the cell. Developing bioinformatics tools has been integral to advancing genomics and p

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6

Stebbins, Nathan Wilson. "Decoding structure-function relationships of glycans." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/110887.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 236-275).<br>Glycans are an important class of biological molecules that regulate a variety of physiological processes such as signal transduction, tissue development and microbial pathogenesis. However, due to the structural complexity of glycans and the unique intricacies of glycan-protein interactions, elucidating glycan structure-function relationships is challenging. Thus, uncovering the biological functio

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7

Bohm, Raphael. "Structural Insights into Glycan Interactions of Human Pathogens." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/366018.

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Glycans are major components of every cell surface. In addition to their importance in many physiological processes, glycans play a key role during infection of many pathogens. The identification and characterisation of glycan-pathogen interactions at a molecular and atomic level is therefore a crucial step towards the design of novel antimicrobial drugs and vaccines. Protein functions related to glycan interactions include glycan biosynthesis (glycosyltransferases), glycan recognition (lectins) and glycan degradation (glycosylhydrolases). This thesis investigates structure-function r

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8

Yosief, Hailemichael. "Synthetic glycans for toxin and pathogen detection." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367936841.

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9

Prokopishyn, Nicole Lesley. "Integrin Ã3ß1, cancer-associated glycans and colon cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23967.pdf.

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10

Sun, Yan Jenny. "Glycans of cationic peanut, Arachis hypogaea L., peroxidase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ30702.pdf.

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11

Granovsky, Maria. "ß1,6GlcNAc-branched N-glycans regulate inflammation and cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0016/NQ45749.pdf.

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12

Haynie, Teron D. "Synthesis of Bacterial Surface Glycans for Conjugate Vaccines." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8669.

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Bacteria are coated with repeating units of oligosaccharides that exhibit remarkable diversity. Often, glycan units of three or even two sugars are sufficient to identify a species of bacteria. Such specificity makes bacterial surface glycans attractive vaccine targets. However, efforts to create effective vaccines against carbohydrates have been hampered by poor vaccine design as well as the human immune tendency to respond to glycan antigens with non-specific, T-cell independent mechanisms. As a result, carbohydrate vaccines have historically produced only adequate memory responses in health

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13

Hatch, Duane M. "Synthetic Multivalent Glycans for the Detection of Pathogens." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1236054639.

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14

Mackeen, Muhammad Mukram Mohamed. "A structural study of N-linked glucosylated oligomannose glycans." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414231.

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15

Chandrasekaran, Aarthi. "Glycans in host-pathogen interactions : an integrated biochemical investigation." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/61219.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The epithelial cell-extracellular matrix interface primarily comprises of complex glycans and glycoconjugates. The widespread distribution of these glycans on the epithelial cell surface makes them ideal targets for interaction with microbial pathogens. In this thesis, a framework of integrated approaches was developed to characterize the structure-function relationships of host cell surface glycans and examine their

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16

Mabusela, Wilfred Thozamile. "Some non-cellulosic b-D-Glycans from plant sources." Doctoral thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/16407.

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Includes bibliographical references.<br>The structures of some non-cellulosic β D-Glycans from three plant sources have been investigated and each was found to be characterised by linked D-pyranosyl a main chain consisting of β -(1-44)- sugars. The polysaccharides were, however, different in structural features in a manner apparently related to their respective locations within the organs of the plants concerned. The polysaccharides were isolated and purified using standard fractionation methods including chromatographic techniques and selective precipitation methods. Structural information wa

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17

McKinnon, Thomas Antony Jude. "Von Willebrand factor glycans : modifiers of function & proteolysis." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/7380.

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18

Stairs, Shaun Robert. "The development of new agents for molecular imaging of glycans." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648256.

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19

Kulkarni, Ashish. "Tailored Glycans For the Precise Detection of Toxins and Pathogens." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1296591686.

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20

Mahajan, Sujit S. "Glycans for ricin and Shiga toxins: Synthesis and biophysical characterization." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307320080.

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21

Wheeler, Kelsey M. (Kelsey Morgan). "The influence of mucin glycans on microbial virulence and competition." Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130819.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, February, 2021<br>Cataloged from the official PDF of thesis.<br>Includes bibliographical references.<br>The human body is colonized by trillions of microbes, many of which reside in a layer of mucus that covers all wet epithelia in the body. In this way, mucus serves as the first line of defense to the host, simultaneously protecting against pathogens while providing a habitat where commensal microbes thrive. It has long been known that defects in mucus production or biochemistry are associated with opportunistic inf

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22

Calabretta, Phillip Joseph. "Methods for the structural modification and characterization of bacterial glycans." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122712.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019<br>Cataloged from PDF version of thesis. Page 184 blank.<br>Includes bibliographical references (pages 151-183).<br>Despite the importance of carbohydrates in cellular processes, there are few tools for their study in the context of a cell. The finding that non-natural monosaccharides could be internalized, processed, and displayed in cellular glycans in the early 1990s led to the development of metabolic incorporation probes for mammalian and microbial organisms. Taking advantage of the development of rapid,

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23

Alm, Johanna. "Method development for identification of N-linked glycans by high performance anion exchange chromatography with pulsed amperometric detection and time of flight mass spectrometry." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66232.

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In the biopharmaceutical industry, identification of glycans in a glycoprotein is a regulatory requirement and is a part of the characterization of the protein. Glycans are constructed of several monosaccharides linked together. N-linked glycans, which have been studied in this project, are attached to the nitrogen atom in asparagine. A method for separating N-linked glycans by high performance anion exchange chromatography had already been developed at the department. To develop a method for identification of the N-glycans by mass spectrometry, a desalting method on porous graphitic carbon (P

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24

Linehan, Sheena Alice. "Towards an integrated understanding of the mannose receptor in homeostasis and immunity." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325281.

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25

Zhang, Ganlin. "Tau protein, oxidative stress and glycosaminoglycan mimetics. Links for new therapeutic possibilities in Alzheimer’s disease." Thesis, Paris Est, 2011. http://www.theses.fr/2011PEST0104.

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26

Bouyain, Samuel. "Binding of fucosylated and anionic glycans to C-type animal lectins." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393429.

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27

Osborne, Chloe E. "Functional role of Helix pomatia binding glycans in breast cancer metastasis." Thesis, Oxford Brookes University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402293.

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28

Walther, Trevenan Jason. "Exploration of respiratory tract glycans by MALDI-ToF and lectin histochemistry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45860920.

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29

Wainman, Yéléna Alexandra. "Developing novel chemical probes for molecular imaging of glycans in cancer." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708565.

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30

Almeida, Andreia Filipa Ferreira de. "Detection of tumor-associated sialylated O-glycans by MALDI-TOF/TOF." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10673.

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Mestrado em Bioquímica Clínica<br>Uma das alterações fenótipicas mais comuns nos tumores são modificações no padrão de O-glicosilação na superfície da célula e nas glicoproteínas secretadas. Como consequência têm implicações nas suas funções biológicas. Em particular, tem sido descrito que algumas células tumorais sobreexpressam ou expressam de novo antigénios associados ao antigénio Thomsen-Friedenreich (TF), ou seja, sialil-Tn, sialil-T e disialyl-T. Estes epítopos resultam da paragem prematura do processo de O-glicosilação em proteínas e têm um impacto direto sobre a biologia do tum

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31

RUSTIGHI, ISABELLA. "PRODUCTION AND STRUCTURAL INVESTIGATION OF GLYCANS AND PROTEINS OF GLYCOBIOLOGICAL RELEVANCE." Doctoral thesis, Università degli studi di Trieste, 2007. http://thesis2.sba.units.it/store/handle/item/12289.

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2004/2005<br>Se si considerano i carboidrati non solo per il loro più semplice ruolo di riserva energetica nel sostentamento de11a vita ma anche per que11o più intrigante di modulatori della comunicazione cellulare, entriamo nel campo della glicobiologia. Quest'aspetto non-triviale della funzione dei glicani deriva dalla loro inerente complessità strutturale (grande varietà di legami e possibilità di ramificazione) e dalla loro localizzazione ubiquitaria nella cellula e nella matrice extracellulare. La maggior parte dei glicani ricopre densamente la parte esterna della superficie cellulare ed

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32

Quinn, Robert Peter. "A Novel Role for Gtb1p in Glucose Trimming of N-linked Glycans." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509888.

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33

Jayo, Roxana Gabriela. "Capillary electrophoresis mass spectrometry for the characterization of glycoproteins and N-glycans." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/51488.

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Glycosylation of proteins is ubiquitous and has the ability to significantly alter the biological and biophysical properties of proteins. The need to study structure-function relationships of glycans in a living organism requires the continuous development of rapid and sensitive technologies for the characterization of glycan components. In recent years, a broad range of technologies have evolved to provide new developments and emerging glycomics techniques. In this thesis we present the development of new methodologies based on capillary electrophoresis-electrospray ionization-mass spectromet

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34

Hiyama, Jun. "Isolation and characterisation of N-glycans of ovine and human luteinizing hormones." Thesis, University of Auckland, 1991. http://hdl.handle.net/2292/1989.

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Gonadotrophic hormones are heterodimeric glycoproteins and their N-glycans attached to specific amino acid residues are currently thought to play important roles in hormonal biosynthesis, secretion and function. The studies reported in this thesis aimed at isolation and characterisation of structural properties of the N-glycans on ovine and human luteinizing hormones. Initially, chromatographic methods were developed using reverse-phase HPLC for the analytical separation of the three human pituitary glycoprotein hormones and their subunits. Separation of intact oLH and its subunits was also ef

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35

Löfling, Jonas. "Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-695-6/.

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36

Zhao, Fan. "Complex N-glycans are Required for Carbohydrate Antigen Presentation by MHC II." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278621860.

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37

Lomax-Browne, Hannah Jane. "Interactions between cancer cell glycans and endothelial cells during adhesion events in metastasis." Thesis, Oxford Brookes University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501906.

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Metastasis, the process by which cancer spreads in the body, is a complex, multi-step cascade which is poorly understood and is the cause of death of most cancer patients. Aberrant glycosylation is an established characteristic of cancer cells and appears to have a role in metastatic mechanisms. The lectin from Helix pomatia, the Ron (Helix pomatia agglutinin, HPA), recognises aberrant glycans terminating in α-N-acetylgalactosamine (GalNAc). The presence of GalNAc-glycans on cancer cell surfaces, detected by HPA binding, is associated with metastasis and consequent poor survival.

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38

Crowe, Kelly Eileen. "Glycans and glycoproteins as biomarkers and treatments for muscular dystrophies and genetic myopathies." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531224059641188.

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39

Gump, Jacob Morris. "The mechanism of TAT-mediated cellular transduction role of glycans and Rab GTPases /." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3366965.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed Aug. 19, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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40

Ng, Seang Khi Preston. "The Role of Distinct Host Glycans in the Evolution of Host Adapted Pathogens." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/365445.

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Glycans are carbohydrate structures coating the cell surface of virtually all nucleated cells of vertebrates. A crucial function of glycans is in cell interaction and recognition, which is constantly exploited by bacteria and viral pathogens as targets for toxins, and as a receptor to aid recognition of and adhesion to host cells. Sialic acids, a 9-carbon compound commonly added as a terminal sugar on glycoconjugates is crucial to both bacteria and viruses causing a successful infection. Bacterial pathogens utilize sialic acids as a component of LOS and capsule, both key virulence factors. The

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41

Gomes, Ferreira Ines Isabel <1992&gt. "Functional relationship of colorectal cancer-associated glycans with malignant phenotype and transcriptome changes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8874/1/PhD%20thesis_Ines%20Ferreira.pdf.

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Glycosyltransferases ST6GAL1 and B4GALNT2 (and their cognate antigens Sia6LacNAc and Sda, respectively) are associated with colorectal cancer (CRC) but it is not fully clear their biological and clinical significance. We explored the clinical relevance of both glycosyltransferases by interrogating The Cancer Genome Atlas (TCGA) database while the phenotypic/transcriptomic effects of ST6GAL1/B4GALNT2 overexpression were studied in genetically modified CRC cell lines. Transcriptomic data from CRC patients in TCGA database suggested a moderate impact of ST6GAL1 on CRC progression, although it wa

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42

Revers, Leigh. "Studies on the expression, purification, and synthetic utility of recombinant yeast #beta#-1,4-mannosyltransferase." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318640.

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43

Notaro, Anna. "Understanding the innovative viral glycosylation machinery using a combination of chemical and structural methodologies." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0125.

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The sujet de cette these portait sur la caractérisation de la machinerie originale utilisée par les Mimiviridae pour glycosyler les fibrilles entourant leurs capsides en travaillant sur les prototypes des 3 lignées connues, Mimivirus (A), Megavirus chilensis (B) et Moumouvirus australensis (C). Les fibrilles de Mimivirus sont décorées par 2 polysaccharides différents :l’un est caractérisé par la répétition d’un disaccaride linéaire fait de 3)-α-L-Rha-(1→3)-β-D-GlcNAc-(1→, avec un pyruvate branché en position 4,6 du GlcNAc ; l’autre présente une unité répétée branchée de séquence 2)-α-L-Rha-(1→

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44

Zhu, Yanping. "Analysing the mechanisms by which bacteria deconstruct mammalian N-glycans and plant-derived Arabinoxylans." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531731.

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45

Silva, Lisete Machado e. "Structural analysis of glycans and development of microarrays from Helcobacter pylori cell surface glycome." Doctoral thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15453.

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Doutoramento em Bioquímica<br>Helicobacter pylori is a bacterial pathogen that affects more than half of the world’s population with gastro-intestinal diseases and is associated with gastric cancer. The cell surface of H. pylori is decorated with lipopolysaccharides (LPSs) composed of three distinct regions: a variable polysaccharide moiety (O-chain), a structurally conserved core oligosaccharide, and a lipid A region that anchors the LPS to the cell membrane. The O-chain of H. pylori LPS, exhibits unique oligosaccharide structures, such as Lewis (Le) antigens, similar to those present

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46

Bröcker, Felix [Verfasser]. "Towards vaccines and therapeutic antibodies against Clostridium difficile based on synthetic glycans / Felix Bröcker." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1116344718/34.

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Hotaling, Nathan Alexander. "Elucidation and optimization of molecular factors for dendritic cell responses to surface presented glycans." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52177.

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Dendritic cells (DCs) are regulators of the immune system and express a class of pattern recognition receptors known as C-type lectin receptors (CLRs) to recognize and respond to carbohydrates (glycans). Dendritic cells are hypothesized to be key mediators in the immune response to implanted materials and ligation of CLRs has been shown to have diverse effects on DC phenotype ranging from tolerogenic to pro-inflammatory. Thus, designing future biomaterials and combination products that harness the potential of CLR ligation on DCs has great promise. Additionally, many of the proteins which ad

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48

Wang, Chung-Yao. "The urothelial glycome : towards differential analysis of N- and O-glycans at the apical surface." Thesis, University of York, 2018. http://etheses.whiterose.ac.uk/20376/.

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Normal mammalian urothelium lines the majority of the urinary tract performing a barrier function against penetration of toxic substances and adventitious microorganisms from the urine. These protective functions of the urothelium are dependent on the correct differentiation of urothelial cells, relying on protein expression, modification and complex assembly to regulate the basal to apical organisation of multiple cell layers, including the highly-differentiated lumen-facing superficial cell. As a poorly studied part of the urothelial differentiation programme, protein glycosylation is report

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49

Jaiswal, Nidhi. "Analysis of Folate Binding Protein and Associated N-Glycans by Mass Spectrometry and Light Microscopy." University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302210585.

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50

Devakumar, ArugaDoss. "Applications of 157 nm light photofragmentation for the structural characterization of isomeric glycans and lipids." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3319919.

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Thesis (Ph. D.)--Indiana University, Dept. of Chemistry, 2008.<br>Title from PDF t.p. (viewed May 13, 2009). Source: Dissertation Abstracts International, Volume: 69-08, Section: B, page: 4721. Adviser: James P. Reilly.

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