Relevant bibliographies by topics / Glycan derivatives

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Glycan derivatives'

Author: Grafiati
Published: 14 March 2023

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Journal articles on the topic "Glycan derivatives"

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Park, Sungjin, Jung-Won Sung, and Injae Shin. "Fluorescent Glycan Derivatives: Their Use for Natural Glycan Microarrays." ACS Chemical Biology 4, no. 9 (September 18, 2009): 699–701. http://dx.doi.org/10.1021/cb9002078.

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Zhang, Yao Y., Ahmed M. Senan, Ting Wang, Li Liu, and Josef Voglmeir. "1-(2-Aminoethyl)-3-methyl-1H-imidazol-3-ium tetrafluoroborate: synthesis and application in carbohydrate analysis." Pure and Applied Chemistry 91, no. 9 (September 25, 2019): 1441–50. http://dx.doi.org/10.1515/pac-2019-0117.

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AbstractReductive alkylation of the carbonyl group of carbohydrates with fluorescence or ionizing labels is a prerequisite for the sensitive analysis of carbohydrates by chromatographic and mass spectrometric techniques. Herein, 1-(2-aminoethyl)-3-methyl-1H-imidazol-3-ium tetrafluoroborate ([MIEA][BF4]) was successfully synthesized usingtert-butylN-(2-bromoethyl)carbamate andN-methylimidazole as starting materials. MIEA+was then investigated as a multifunctional oligosaccharide label for glycan profiling and identification using LC-ESI-ToF and by MALDI-ToF mass spectrometry. The reductive amination of this diazole with carbohydrates was exemplified by labelingN-glycans from the model glycoproteins horseradish peroxidase, RNase B, and bovine lactoferrin. The produced MIEA+glycan profiles were comparable to the corresponding 2AB labeled glycan derivatives and showed improved ESI-MS ionization efficiency over the respective 2AB derivatives, with detection sensitivity in the low picomol to the high femtomol range.
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Hung, Wei-Ting, Yi-Ting Chen, Chung-Hsuan Chen, Yuan Chuan Lee, Jim-Min Fang, and Wen-Bin Yang. "Flow Chemistry System for Carbohydrate Analysis by Rapid Labeling of Saccharides after Glycan Hydrolysis." SLAS TECHNOLOGY: Translating Life Sciences Innovation 25, no. 4 (June 19, 2020): 356–66. http://dx.doi.org/10.1177/2472630320924620.

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This study demonstrates the utilization of a flow chemistry system for continuous glycan hydrolysis and saccharide labeling to assist with the existing methods in glycan structural analysis. Acidic hydrolysis of glycans could be accelerated in a flow system. Aldoses and α-ketoacid-type saccharides were effectively labeled with naphthalene-2,3-diamine (NADA) at 60 °C for 10 min to form the fluorescent naphthimidazole (NAIM) and quinoxalinone (QXO) derivatives, respectively. The NADA-labeled derivatives improved the structural determination and composition analysis for their parent saccharides by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), liquid chromatography mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR). Furthermore, this protocol was applied to determine the SA–Gal–Glc sequence of GM3-sugar out of six possible permutations.
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Tang, Jo Sing Julia, Sophia Rosencrantz, Lucas Tepper, Sany Chea, Stefanie Klöpzig, Anne Krüger-Genge, Joachim Storsberg, and Ruben R. Rosencrantz. "Functional Glyco-Nanogels for Multivalent Interaction with Lectins." Molecules 24, no. 10 (May 15, 2019): 1865. http://dx.doi.org/10.3390/molecules24101865.

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Interactions between glycans and proteins have tremendous impact in biomolecular interactions. They are important for cell–cell interactions, proliferation and much more. Here, we emphasize the glycan-mediated interactions between pathogens and host cells. Pseudomonas aeruginosa, responsible for a huge number of nosocomial infections, is especially the focus when it comes to glycan-derivatives as pathoblockers. We present a microwave assisted protecting group free synthesis of glycomonomers based on lactose, melibiose and fucose. The monomers were polymerized in a precipitation polymerization in the presence of NiPAm to form crosslinked glyco-nanogels. The influence of reaction parameters like crosslinker type or stabilizer amount was investigated. The gels were characterized in lectin binding studies using model lectins and showed size and composition-dependent inhibition of lectin binding. Due to multivalent presentation of glycans in the gel, the inhibition was clearly stronger than with unmodified saccharides, which was compared after determination of the glycan loading. First studies with Pseudomonas aeruginosa revealed a surprising influence on the secretion of virulence factors. Functional glycogels may be in the future potent alternatives or adjuvants for antibiotic treatment of infections based on glycan interactions between host and pathogen.
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Fujikawa, Kohki. "Glycan Derivatives That Possess Chaperone-Like Activity." Trends in Glycoscience and Glycotechnology 30, no. 177 (November 25, 2018): E241—E243. http://dx.doi.org/10.4052/tigg.1831.6e.

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Fujikawa, Kohki. "Glycan Derivatives That Possess Chaperone-Like Activity." Trends in Glycoscience and Glycotechnology 30, no. 177 (November 25, 2018): J201—J202. http://dx.doi.org/10.4052/tigg.1831.6j.

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Brockhausen, Inka, Gabriele Möller, Annette Pollex-Krüger, Volker Rutz, Hans Paulsen, and Khushi L. Matta. "Control of O-glycan synthesis: specificity and inhibition of O-glycan core 1 UDP-galactose:N-acetylgalactosamine-α-R β3-galactosyltransferase from rat liver." Biochemistry and Cell Biology 70, no. 2 (February 1, 1992): 99–108. http://dx.doi.org/10.1139/o92-015.

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The specificity of glycosyltransferases is a major control factor in the biosynthesis of O-glycans. The enzyme that synthesizes O-glycan core 1, i.e., UDP-galactose:N-acetylgalactosamine-α-R β3-galactosyltransferase (β3-Gal-T; EC 2.4.1.122), was partially purified from rat liver. The enzyme preparation, free of pyrophosphatases, β4-galactosyltransferase, β-galactosidase, and N-acetylglucosaminyltransferase I, was used to study the specificity and inhibition of the β3-Gal-T. β3-Gal-T activity is sensitive to changes in the R-group of the GalNAcα-R acceptor substrate and is stimulated when the R-group is a peptide or an aromatic group. Derivatives of GalNAcα-benzyl were synthesized and tested as potential substrates and inhibitors. Removal or substitution of the 3-hydroxyl or removal of the 4-hydroxyl of GalNAc abolished β3-Gal-T activity. Compounds with modifications of the 3- or 4-hydroxyl of GalNAcα-benzyl did not show significant inhibition. Removal or substitution of the 6-hydroxyl of GalNAc reduced activity slightly and these derivatives acted as competitive substrates. Derivatives with epoxide groups attached to the 6-position of GalNAc acted as substrates and not as inhibitors, with the exception of the photosensitive 6-O-(4,4-azo)pentyl-GalNAcα-benzyl, which inhibited Gal incorporation into GalNAcα-benzyl. The results indicate that the enzyme does not require the 6-hydroxyl of GalNAc, but needs the 3- and the axial 4-hydroxyl as essential requirements for binding and activity. In the usual biochemical O-glycan pathway, core 2 (GlcNAcβ6[Galβ3]GalNAcα-) is formed from core 1 (Galβ3GalNAc-R). We have now demonstrated an alternate pathway that may be of importance in human tissues.Key words: β3-Gal-transferase, mucin synthesis, O-glycan core 1, enzyme specificity, enzyme inhibition.
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Yamada, Keita, Jun Hirabayashi, and Kazuaki Kakehi. "Analysis of O-Glycans as 9-Fluorenylmethyl Derivatives and Its Application to the Studies on Glycan Array." Analytical Chemistry 85, no. 6 (March 2013): 3325–33. http://dx.doi.org/10.1021/ac303771q.

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Pikora, Cheryl, Christine Wittish, and Ronald C. Desrosiers. "Identification of Two N-Linked Glycosylation Sites within the Core of the Simian Immunodeficiency Virus Glycoprotein Whose Removal Enhances Sensitivity to Soluble CD4." Journal of Virology 79, no. 19 (October 1, 2005): 12575–83. http://dx.doi.org/10.1128/jvi.79.19.12575-12583.2005.

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ABSTRACT Using PCR mutagenesis to disrupt the NXT/S N-linked glycosylation motif of the Env protein, we created 27 mutants lacking 1 to 5 of 14 N-linked glycosylation sites within regions of gp120 lying outside of variable loops 1 to 4 within simian immunodeficiency virus strain 239 (SIV239). Of 18 mutants missing N-linked glycosylation sites predicted to lie within 10 Å of CD4 contact sites, the infectivity of 12 was sufficient to measure sensitivity to neutralization by soluble CD4 (sCD4), pooled immune sera from SIV239-infected rhesus macaques, and monoclonal antibodies known to neutralize certain derivatives of SIV239. Three of these 12 mutants (g3, lacking the 3rd glycan at position 79; g11, lacking the 11th glycan at position 212; and g3,11, lacking both the 3rd and 11th glycans) were approximately five times more sensitive to neutralization by sCD4 than wild-type (WT) SIV239. However, these same mutants were no more sensitive to neutralization than WT by pooled immune sera. The other 9 of 12 replication-competent mutants in this group were no more sensitive to neutralization than the WT by any of the neutralizing reagents. Six of the nine mutants that did not replicate appreciably had three or more glycosylation sites eliminated; the other three replication-deficient strains involved mutation of site 15. Our results suggest that elimination of glycan attachment sites 3 and 11 enhanced the exposure of contact residues for CD4. Thus, glycans at positions 3 and 11 of SIV239 gp120 may be particularly important for shielding the CD4-binding site from antibody recognition.
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Soriano del Amo, David, Wei Wang, Christen Besanceney, Tianqing Zheng, Yizheng He, Brian Gerwe, Ronald D. Seidel, and Peng Wu. "Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives." Carbohydrate Research 345, no. 9 (June 2010): 1107–13. http://dx.doi.org/10.1016/j.carres.2010.03.032.

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Dissertations / Theses on the topic "Glycan derivatives"

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Williams, Matthew. "The development of S-glycosylcysteine derivatives for use in glycan-binding assays." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25655.

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This dissertation concerns the development of a synthetic route towards novel cysteine-based glycan-binding probes, for incorporation into glycoarrays and or similar applications used in assays of glycan-recognition phenomena. The need to systematically characterize the glycome and decipher the range of glycosylation patterns found in living cells, has prompted the development of molecular tools such as glycoarrays and related systems for immobilizing defined carbohydrate structures. The preparation of these probes requires access to building blocks where the core structure has defined glycans together with appropriate linkers, and the amino acid cysteine is explored here as one such structure. In particular, this dissertation describes the synthesis of a S-glucosylcysteine derivative SGC, or methyl N-(6-aminohexanoyl)-S-(β-D-glucopyranosyl)-L-cysteinate trifluoroacetate 67, as well as its 2-acetamido analogue SAGC, or methyl N-(6-aminohexanoyl)-S-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-L-cysteinate trifluoroacetate 74. The first approach involved initial preparation of N-(4-azidobutanoyl)-L-cysteine 12 and attempted reaction of this with 1,2,3,4,6-penta-O-acetyl-β-D-glucopyranose 3 to form the initial target of this dissertation, bis-glucoside 13. This was not successful, but repetition of the reported reaction involving the use of N-acetyl-L-cysteine 4 provided a modest yield of partially purified bis-glucosyl cysteine (BGC, 1). A mechanism for this one-pot, sequential bis-glucosylation is proposed. The limitations of the one-pot procedure led to investigation of alternative methods for the step-wise introduction of sugar units to the cysteine core. For this purpose the cysteine derivative, methyl N-(6-((tert-butoxycarbonyl)amino)hexanoyl)-L-cysteinate 40, was prepared and reacted with 3 to obtain a fully protected precursor of the target SGC. However, inefficiencies in this procedure led to investigation of an alternative strategy for preparation of SGC.
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Garg, Monika [Verfasser]. "Conformational Analysis and Application in Diagnostic of Glycosylphosphatidylinositol Glycan Derivatives / Monika Garg." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1155761057/34.

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Puliti, Elisa. "Role of sphingosine 1-phosphate metabolism and signalling in skeletal muscle atrophy and fibrosis." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1195603.

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In the last 30 years, multiple roles of S1P have been demonstrated in the regulation of skeletal muscle biology. The presented study is focused on the role of S1P metabolism in myogenic differentiation, where SPL was found playing a crucial role in regulating S1P cellular levels and responsible for onset of myogenic program. The role of S1P axis was also confirmed in skeletal muscle atrophy induced by TNF-alpha. S1P signalling pathwayplays a crucial role in the development and maintenance of the fibrotic process. New S1P3 antagonists were tested to antagonise the receptor involved in fibrosis, and new SK inhibitors have been designed on the base of PF-543, with the aim to develop glycohybrids as potential pharmacological tool in skeletal muscle fibrosis. The metabolism of S1P appears a promising drug targets for pharmacological therapies in skeletal muscle repair.
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Gruškienė, Rūta. "Cationized and poly(ethylene glycol) modified chitosan derivatives and nanoparticles." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105158-57314.

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The main aim of this work was to synthesize water-soluble chitosan – methoxy poly(ethylene glycol) (MPEG) graft copolymers and cationized chitosan derivatives of various structure and desirable graft density, and to study their properties. Novel chitosan-MPEG derivatives with different degree of substitution of chitosan were prepared for the first time by “click” chemistry. Several new schemes of the synthesis of chitosan-MPEG and additionally cationized chitosan derivatives were suggested based on protection of amino functionality by using chitosan-dodecyl sulphate complexes. Additional cationization of chitosan through its hydroxyl groups in alkaline medium enabled to prepare chitosan derivatives with very high charge density. A method of enzymatic hydrolysis of the cationized chitosans was proposed which allowed a tenfold decrease of the molecular weight of chitosan derivatives. Modification of chitosan by tartaric, citric or adipic acid yielded chitosan nanoparticles. Further modification of chitosan nanoparticles by dithiobenzendicarboxylate resulted in RAFT macroinitiators used as precursors of functionalized nanoparticles.
Pagrindinis šio darbo tikslas buvo susintetinti vandenyje tirpius norimos struktūros bei pakeitimo laipsnio skiepytuosius chitozano – polietilenglikolio (MPEG) kopolimerus bei katijonizuotus chitozano darinius ir ištirti jų savybes. Įvairaus pakeitimo laipsnio chitozano-MPEG skiepytieji kopolimerai susintetinti vykdant „klik“ chemijos reakcijas. Pasiūlyti nauji chitozano-MPEG bei papildomai katijonizuoto chitozano sintezės būdai, chitozano aminogrupių apsaugai naudojant chitozano kompleksus su dodecilsulfatu. Dalinai katijonizuoto chitozano darinius papildomai katijonizuojant šarminėje terpėje, gauti chitozano dariniai, turintys labai didelį krūvio tankį. Pasiūlytas katijonizuoto chitozano fermentinės hidrolizės metodas, kurį naudojant chitozano darinio molekulinę masę lengvai galima sumažinti dešimtimis kartų. Chitozaną modifikuojant vyno, citrinų arba adipo rūgštimis, susintetintos nanodalelės. Prie chitozano nanodalelių prijungus (4-cianpentano rūgšties)-4-ditiobenzenkarboksilatą, susintetintas makroiniciatorius gyvybingajai radikalinei polimerizacijai RAFT metodu.
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Peters, Scott O. "Induced pi-facial discrimination in the alkylation of chiral derivatives of glycine." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0014/MQ52745.pdf.

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Idziak, Irene. "Synthesis of amide-backbone DNA analogues and their poly(ethylene glycol) derivatives." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40145.

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Thymidine dimers 16 and 18, connected by amide or N-methylamide linkages, have been prepared. The dimers were incorporated into normal strands of DNA by solid phase synthesis. Thermal denaturation studies, using complementary single-stranded RNA, indicated that these modifications caused no destabilization of the DNA-RNA duplex.
The block synthesis of amide-linked homotetramer 30 is described. The synthesis of the corresponding octamer could not be verified because of lack of solubility. One by one homologation was found to be a suitable method for the preparation of N-methylamide analogues.
Poly(ethylene glycol), covalently attached to the 3$ sp prime$ or 5$ sp prime$ end of amide-backbone thymidine homopolymers, was found to greatly increase their solubility. The poly(ethylene glycol) simultaneously served as a soluble solid support for the homologation reactions.$ sp*$ ftn$ sp*$Please refer to the dissertation for diagram.
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Carter, James. "A New Synthetic Pathway Towards Legionaminic Acid." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/381511.

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This thesis describes the results of a PhD project aimed at researching a new synthetic pathway towards legionaminic acid analogues. Legionaminic acid is a bacterial family of nonulosonic acids expressed in a terminal position on the flagellar glycans and are considered to be a virulence factor in the pathogenic bacteria that possess them. At the outset of this project several examples of Leg synthesis had been published. Whilst three syntheses of Leg derivatives have been published while the research described in this thesis was being carried out, the potential of all the published syntheses of Leg to efficiently generate C-7 analogues is very limited. There are a number of C-7 analogues of legionaminic acid that occur in nature, and additionally it is the functionality at C-7 which primarily separates the bacterial nonulosonic acids from the those found in animals (in addition to being 9-deoxy). It was therefore the goal of this project to develop a synthetic chemical pathway that is adaptable towards a number of C-7 analogues of legionaminic acid, and potentially other analogues that may be considered of value. It was also key to our approach that we were able to produce these analogues of legionaminic acid from a common precursor. Chapter one of this thesis introduces in detail the literature background of the nonulosonic acids, in particular the bacterial nonulosonic acids pseudaminic acid, legionaminic acid, and the recently discovered acinetaminic acid. It discusses the natural occurrence of these molecules and gives a complete overview of all existing synthetic pathways: chemical, enzymatic, and chemoenzymatic. Chapter two describes our initial approach towards the synthesis of legionaminic acid and 7-epi-legionaminic acid. N-Acetylneuraminic acid was selected as the starting material due to its commercial availability and structural similarities to legionaminic acid. The transformations required to convert Neu5Ac to legionaminic acid were the deoxygenation of carbons seven and nine, and the introduction of an acetamide to carbon seven. We based our initial approach on the synthesis of 8-epi-pseudaminic acid previously completed in our group. To this end, Neu5Ac was selectively protected to leave the only free hydroxyl group at carbon seven, which was activated and displaced with a nitrogen nucleophile. The remainder of the approach consisted of the removal of the protecting groups, acylation of the C-7 nitrogen, and deoxygenation of carbon nine, however the deoxygenation step provided us with insurmountable difficulties. In chapter three, the investigation into the synthesis of Leg2en analogues is discussed. Analogues of nonulosonic acids with a double bond between carbons two and three have proven to be of value in the past, and with the discovery of a putative glycohydrolase enzyme for pseudaminic acid, Leg2en and Pse2en analogues could well prove to be just as valuable. An analogous approach to that discussed in chapter 2 is taken, with the difference being that Neu5Ac is converted to Neu5Ac2en prior to selective protection and the introduction of the C-7 nitrogen. Once again, the acetamido functionality was successfully introduced to carbon seven, but the deoxygenation of carbon nine could not be accomplished. In chapter four, a revised approach towards legionaminic acid and 7-epi-legionaminic acid is described. This approach avoided the previously encountered problems with C-9 deoxygenation by performing it early in the synthesis and introducing the nitrogen functionality to C-7 of 9-deoxy-Neu5Ac. With this new approach, 7-epi-legionaminic acid and legionaminic acid were both successfully synthesised, with the functionalisation of the C-7 nitrogen step being performed at the very end of the synthesis, prior only to the removal of protecting groups. This therefore allows for the investigation into a number of different functionalisation steps that could be performed on the protected 7-amino-legionaminic acid substrate. The final chapter, chapter five, details our investigations into an interesting and important by-product that we isolated during the activation of the C-7 hydroxyl on multiple substrates. This by-product was identified as a dihydro-1,3-oxazine derivative, which had formed between carbon seven and the acetamide of carbon five. We explored the different conditions under which this by-product formed and found that we could control relatively well whether the C-7 activated Neu5Ac would convert to the oxazine by changing the base used, and in what proportions. We also investigated opening this oxazine by-product, with the hope that we could use its inverted stereochemistry as an avenue towards legionaminic acid stereochemistry, which we were eventually able to do.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Science, Environment, Engineering and Technology
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Bright, Andrew G. "Mechanistic Insights into the Stabilisation of Biopharmaceuticals using Glycine Derivatives. The Effect of Glycine Derivatives on the Crystallisation, Physical Properties and Behaviour of Commonly used Excipients to Stabilise Antigens, Adjuvants and Proteins in the Solid State." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/15943.

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This dissertation has focused on studying the effect of four glycine derivatives on the solid state properties of mannitol, glycine, and sucrose when freeze dried into blended mixtures. The primary goal was to assess their value for use in the stabilisation of vaccines in the solid state, by examining key physical and chemical characteristics, which have been documented to be beneficial to the stabilisation of biopharmaceutical formulations. The novel excipients; dimethyl glycine, and trimethyl glycine, were shown to retard the crystallisation and increase the overall glass transition temperature, of mannitol, when freeze dried as evidenced by DSC and Powder X-ray diffraction. Mannitol’s glass transition temperature increased from 100C to 12.650C and 13.610C when mixed with methyl-glycine and dimethyl glycine respectively. The glycine derivatives did not show the same effect on sucrose which remained amorphous regardless of the concentration of the other excipient. The different behaviour with the sucrose system was thought to be due to relatively high glass transition temperature of sucrose. Conversely glycine remained highly crystalline due it’s relatively low glass transition temperature. The novel excipient formulations were also assessed for their effect on the aggregation of the adjuvant aluminium hydroxide when freeze dried by Dynamic Light Scattering (DLS).The formulations containing the glycine derivatives all caused a decrease in the aggregation size of the adjuvant from ~26 μm, to 185 nm in the presence of methyl glycine. The effects of lysozyme and viral antigen on the adjuvants were also examined showing that the addition of the virus did not affect the size of the aggregates formed, however lysozyme showed significant decreases in the aggregates formed. Examination of the freezing method were also made showing that faster freezing rates produced smaller aggregates of the adjuvant. When investigating the rate at which the excipients lost water during secondary drying there was evidence of the formation of hydrates of glycine, trimethyl glycine, and mannitol has shown that the glycine derivatives have attributes which would be beneficial in stabilising vaccines in the solid state when freeze dried.
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Huo, Hongguang. "Tailored cell attachment and cytotoxicity in PEG-based polysaccharide-derivatized hydrogels." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 117 p, 2007. http://proquest.umi.com/pqdlink?did=1253510481&Fmt=7&clientId=79356&RQT=309&VName=PQD.

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Bagga, Kishore Kumar. "Synthesis of hexamethylmelamine, polyethylene glycol and glucose derivatives for use in anti-cancer and sugar transport studies." Thesis, Aberystwyth University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301609.

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Books on the topic "Glycan derivatives"

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Glyphosate (Environmental Health Criteria , No 159). World Health Organization, 1994.

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Book chapters on the topic "Glycan derivatives"

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Priebe, Waldemar, Izabela Fokt, and Grzegorz Grynkiewicz. "Glycal Derivatives." In Glycoscience, 699–735. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-30429-6_15.

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Harris, J. Milton, M. R. Sedaghat-Herati, P. J. Sather, Donald E. Brooks, and T. M. Fyles. "Synthesis of New Poly(Ethylene Glycol) Derivatives." In Poly(Ethylene Glycol) Chemistry, 371–81. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4899-0703-5_22.

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Priebe, Waldemar, and Grzegorz Grynkiewicz. "Formation and Reactions of Glycal Derivatives." In Glycoscience: Chemistry and Chemical Biology I–III, 749–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56874-9_23.

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Brooks, Donald E., James M. Van Alstine, Kim A. Sharp, and S. Jill Stocks. "PEG-Derivatized Ligands with Hydrophobic and Immunological Specificity." In Poly(Ethylene Glycol) Chemistry, 57–71. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4899-0703-5_4.

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Ferrier, Robert J. "Substitution-with-Allylic-Rearrangement Reactions of Glycal Derivatives." In Topics in Current Chemistry, 153–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-44422-x_7.

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Working, Peter K., Mary S. Newman, Judy Johnson, and Joel B. Cornacoff. "Safety of Poly(ethylene glycol) and Poly(ethylene glycol) Derivatives." In ACS Symposium Series, 45–57. Washington, DC: American Chemical Society, 1997. http://dx.doi.org/10.1021/bk-1997-0680.ch004.

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Zalipsky, Samuel, and Sunitha Menon-Rudolph. "Hydrazide Derivatives of Poly(ethylene glycol) and Their Bioconjugates." In ACS Symposium Series, 318–41. Washington, DC: American Chemical Society, 1997. http://dx.doi.org/10.1021/bk-1997-0680.ch021.

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Hiroto, Misao, Ayako Matsushima, Hiroyuki Nishimura, Yoh Kodera, and Yuji Inada. "Stabilization of L-Asparaginase by Chemical Modification with Poly(Ethylene Glycol) Derivatives." In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 297–98. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2_85.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with sulfurated triazoline derivative of glycine." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 4, 43–45. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62474-6_13.

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Ali, Farhad, Muhammad Saqib, Ilyas Khan, and Nadeem Ahmad Sheikh. "Heat Transfer Analysis in Ethylene Glycol Based Molybdenum Disulfide Generalized Nanofluid via Atangana–Baleanu Fractional Derivative Approach." In Studies in Systems, Decision and Control, 217–33. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11662-0_13.

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Conference papers on the topic "Glycan derivatives"

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Nedeljković, Nikola V., Vladimir D. Dobričić, Marina Ž. Mijajlović, Gordana P. Radić, Miloš V. Nikolić, Ana S. Stanković, and Zorica B. Vujić. "„IN SILICO“ PREDICTION OF PHARMACOKINETIC PROPERTIES AND DRUGLIKENESS OF NOVEL THIOUREA DERIVATIVES OF NAPROXEN." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.371n.

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Masking the carboxyl group of naproxen with other functional groups may be a promising strategy to decrease its gastrointestinal toxicity. Thiourea moiety has been described as an important pharmacophore in a variety of pharmacologically active compounds, including anti-inflammatory, antiviral, anticancer, hypoglycemic and antimicrobial agents. Our research group has previously designed twenty novel thiourea derivatives of naproxen, containing amino acids (glycine, L-alanine, β-alanine, L-valine and L-phenylalanine – compounds 1,2,3,4 and 5, respectively), their methyl (6–10) and ethyl esters (11–15), as well as aromatic amines (16–20). Pharmacokinetic properties and druglikeness of these compounds were predicted using SwissADME web tool (http://www.swissadme.ch/). Predicted pharmacokinetic properties include potential for gastrointestinal absorption, blood-brain barrier permeability, skin permeability, transport mediated by P-glycoproteins and enzyme inhibitory potential. Druglikeness was evaluated using Lipinski’s, Ghose’s, Veber’s, Egan’s and Muegge’s rules, as well as on the basis of bioavailability score. All tested compounds had high-predicted gastrointestinal absorption and low blood-brain barrier permeability. Also, derivatives 2, 4, 7, 9, 10, 12, 14, 15 and 18 were predicted to be substrates for P-glycoprotein. Derivatives with aromatic amines (16–20) showed inhibitory potential against all tested CYP isoforms. Derivative 19 had the highest, while derivative 13 demonstrated the lowest predicted skin permeability. Finally, derivatives 1–12, except 5 and 10, have druglike structures, since they obey to all imposed rules.
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E, Costas do Santos, Glisoni R., Fabian L., Sosnik A., and Moglioni A. "NANOASSEMBLIES: COVALENT DERIVATIVES OF NEVIRAPINE WITH POLYETHYNE GLYCOL DIACRYLATE." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013913132632.

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Arco, Susan, Mark Neil Tolentino, Caidric Gupit, and Eduardo Atayde Jr. "Thermo–Responsive Block Copolymers of Ethylene Glycol Derivatives and Methacrylic Acid." In Annual International Conference on Chemistry, Chemical Engineering and Chemical Process ( CCECP 2016 ). Global Science & Technology Forum ( GSTF ), 2016. http://dx.doi.org/10.5176/2301-3761_ccecp16.9.

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Kamari, Azlan, Siti Najiah Mohd Yusoff, Siew Tin Susana Wong, and I. Wayan Sutapa. "Alkyl glycol chitosan derivatives for encapsulation and controlled release of rotenone." In INTERNATIONAL CONFERENCE ON ENERGY AND ENVIRONMENT (ICEE 2021). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0059890.

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Tan Fang, Kaiguo Ma, Yuting Guo, Zilong Li, and Haiqing Guo. "Assemblies of CdSe and polyethylene glycol derivatives for fluorescent hybrid microspheres." In 2010 IEEE 3rd International Nanoelectronics Conference (INEC). IEEE, 2010. http://dx.doi.org/10.1109/inec.2010.5424709.

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SHAO, Zheng-wei, Ying WANG, Wen-guang WANG, and Jia-ling PU. "The Synthesis of a Novel Swallow-tailed Glycol and Linear Alkoxy-substitued Dibenzocoronene Tetracarboxdiimide Derivatives." In International Conference on Advanced Material Science and Engineeering (AMSE2016). WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789813141612_0078.

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Lamaty, Frédéric, Stéphane Varray, Bérengère Sauvagnat, Christine Gauzy, René Lazaro, and Jean Martinez. "Poly(ethylene glycol) Supported Synthesis of Aminoacid Derivatives via Ring Closing Metathesis or Microwave-assisted Alkylation." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01890.

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Takanokura, Tomoe, Makio Kurashige, Kazutoshi Ishida, Yasuyuki Ohyagi, Masachika Watanabe, and Yeong Hee Cho. "Holographic polymer dispersed liquid crystal system utilizing the co-polymerizations with siloxane compounds and polypropylene glycol derivatives." In SPIE OPTO, edited by Liang-Chy Chien and Hiroshi Yokoyama. SPIE, 2011. http://dx.doi.org/10.1117/12.873681.

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Vosahlikova, Sarka, Irena Kusova Moserova, Jarmila Kralova, Milan Reinis, Romana Mikyskova, and Jitka Palich Fucikova. "Abstract B35: Studies on photo-sensitivity of a glycol porphyrin derivative and its anti-tumor efficacy." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; November 27-30, 2018; Miami Beach, FL. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/2326-6074.tumimm18-b35.

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Putra, I. A. "Selecting An Optimum Hydrophobic Groups From Vegetable Oil Derivative for Surfactants used in Enhanced Oil Recovery." In Indonesian Petroleum Association 44th Annual Convention and Exhibition. Indonesian Petroleum Association, 2021. http://dx.doi.org/10.29118/ipa21-e-250.

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The need for fossil fuels which tends to increase without an increase in oil production has become the main factor in applying the Enhanced Oil Recovery (EOR) methods in the mature oil field. Chemical injection using surfactants is one of the EOR technologies that has been proved to be able to increase oil recovery. In this study, surfactants were synthesized using a fatty acid derived from palm oil as hydrophobic group and polyethylene-glycol as hydrophilic group. The use of vegetable oil as raw material is possible because it is abundant and environmentally friendly. Esterification of nonionic surfactant was performed by utilizing the azeotrope technique (Toluena-H2O) between fatty acid (oleic, stearic, palmitic and lauric acids) and polyethylene glycol (PEG) (200, 300, 400, 600, 1000, and 1500). The reaction was optimized with various moles of fatty acid and PEG equivalents (1:1,1; 1:2,5; 1;3) and various time reaction. Product surfactant was characterized by thin-layer chromatography (TLC) to determine the optimum condition and reaction conversion. The molecular structure of the surfactant was confirmed by 1H NMR. Nonionic surfactant was then analyzed by measuring the interfacial tension (IFT) of oil and water. The results showed that the optimum conditions to obtain the lowest IFT were achieved by reacting hydrophobic groups of oleic acid and hydrophilic groups of PEG-400 at an equivalent mole ratio of 1: 3 and a reaction time of 5 hours. Oleic PEG-400 surfactant was able to decrease the IFT of oil and water as low as 10-4 dyne/cm in brine salinity condition of 18000 ppm and oil 34,39 OAPI. The results was then used to design the synthesis of vegetable surfactant oil with various carbon chain lengths and functional groups as an EOR surfactant hydrophobic group.
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