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Dissertations / Theses on the topic 'GLRA2'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Upton, Laura. "Altered prefrontal circuit assembly and function in mice lacking the glycine receptor α2 subunit, a model of autism and intellectual disability". Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS714.

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Des variants pathogènes du gène GLRA2 codant pour la sous-unité α2 du récepteur glycinergique ont été récemment impliqués dans le trouble du spectre autistique (TSA) et la déficience intellectuelle. Notre groupe a précédemment montré que les souris mâles déficientes en Glra2 (Glra2–/Y) présentent un déficit de mémoire lors du test de reconnaissance d’objets (TRO) et une altération de la plasticité synaptique du cortex préfrontal (CPF), une région fortement impliquée dans le TSA. Par ailleurs, des études développementales des souris Glra2–/Y ont décrit un défaut de migration des interneurones e

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2

Martins, Ana Caroline Vasconcelos. "GluA2 - Glutamatergic Receptor Study: A Molecular Approach." reponame:Repositório Institucional da UFC, 2017. http://www.repositorio.ufc.br/handle/riufc/28258.

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Submitted by José Orlando Soares de Oliveira (orlando.soares@bol.com.br) on 2017-11-30T12:23:47Z No. of bitstreams: 1 2017_tese_acvmartins.pdf: 10270409 bytes, checksum: f2b0eb40db54875e0e40a6d040ce7336 (MD5)<br>Rejected by Weslayne Nunes de Sales (weslaynesales@ufc.br), reason: A aluna optou por publicar apenas os elementos pré-textuais. on 2017-12-01T12:36:51Z (GMT)<br>Submitted by José Orlando Soares de Oliveira (orlando.soares@bol.com.br) on 2017-12-01T13:50:35Z No. of bitstreams: 1 Tese corrigida - elementos pretextuais.pdf: 159585 bytes, checksum: 9531b29bc8c5a46f5ed5753442df383f (M

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3

Jones, Taylor J. "Documentation of grapevine leafroll-associated viruses in wine grape varieties and native grape species in Virginia, and examination of the movement of grapevine leafroll disease to develop management strategies." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/49567.

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Grapevine leafroll-associated virus-2 (GLRaV-2), GLRaV-3, and grapevine fleck virus (GFkV) are widespread in grapes around the world. These viruses can cause significant crop loss and affect wine quality by reducing sugar accumulation and compromising skin color. Mealybugs are vectors of grapevine leafroll-associated viruses (GLRaVs). A statewide survey of commercial and wild grapevines in Virginia was conducted during 2009 through 2011. Also, vector management options were tested in two field studies. GLRaV-2, GLRaV-3, and GFkV were detected in 8%, 25%, and 1%, respectively, of over 1,200 vin

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4

Fazeli, Claudia Fariba. "Molecular detection of grapevine leafroll associated closteroviruses (GLRaVs) and the genome organisation of GLRaV-1." 1998, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phf2868.pdf.

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5

Little, Alan. "Complete sequence, improved detection and functional analysis of Grapevine Leafroll-associated Virus 1(GLRaV-1) /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phl7781.pdf.

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6

Dubes, Sandra. "Rôle du microARN miR-124 dans la plasticité homéostatique via le contrôle de l’expression de la synaptopodine et des récepteurs AMPA dans les neurones de l'hippocampe." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0104.

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Le synaptic scaling est une forme de plasticité homéostatique par lequel les synapses ajustent leur efficacité pour compenser des variations normales ou pathologiques de l'activité neuronale notamment lors des maladies neurodégeneratives ou suite à la perte d’afférences sensorielles après une lésion. Dans un modèle expérimental classique, le traitement chronique des neurones primaires avec la tétrodotoxine (TTX) pour bloquer la propagation des potentiels d'action présynaptiques induit une augmentation significative de l'amplitude des courants miniatures excitateurs transmis par les récepteurs

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7

Alliaume, Antoine. "Biologie de la vection de l'ampélovirus GLRaV-1 et du vitivirus GVA par la cochenille Phenacoccus aceris." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ004.

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L’enroulement de la vigne cause des pertes de rendement et de la qualité des vins au niveau mondial. Il est causé par quatre espèces de Grapevine leafroll-associated virus(GLRaVs) ; GLRaV-1, -2, -3, -4-like. Si le GLRaV-2 (genre Closterovirus) ne possède pas de vecteur connu, les trois autres espèces (genre Ampelovirus) sont transmises par cochenilles(Coccoidea) qui contribuent à leur dispersion dans et entre les vignobles. Les vignobles de la France septentrionale (Alsace, Bourgogne, Champagne) sont les plus impactés par l’enroulement viral. Ce travail a porté sur le rôle vecteur de Phenacocc

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8

Chen, Ting-Jiun [Verfasser], and Maria [Akademischer Betreuer] Kukley. "In vivo regulation of oligodendrocyte precursor cell proliferation and differentiation by AMPA-receptor subunit GluA2 / Ting-Jiun Chen ; Betreuer: Maria Kukley." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1208690213/34.

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9

Carreno, Velazquez Thalia Lizbeth. "Structure-based drug discovery approaches to identify modulators of the Nrf2 pathway and glutamate receptors AMPA GluA2 and Kainate GluK1 and GluK2." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/75046/.

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Nrf2 project: The protein nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that provides protection against oxidative stress and the dysfunction of this pathway has been suggested to be implicated in many neurodegenerative diseases. The aim of this thesis was to identify novel Nrf2 activators that disrupt the protein-protein interaction between Nrf2 and Keap1 and thereby induce increased expression of antioxidant enzymes and protective genes. The crystal structure of the Keap1-Nrf2 interface was used to perform a virtual screen and compounds from the screen were ass

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10

Le, Maguet Jean. "Epidémiologie de l'enroulement viral de la vigne dans les vignobles français septentrionaux et transmission par cochenilles vectrices." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00768382.

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Les virus de l'enroulement de la vigne (Grapevine leafroll-associated virus, GLRaV) sont répandus mondialement et transmis à la vigne uniquement par cochenilles (Coccoidea). En France, l'enroulement viral affecte particulièrement les vignobles des régions septentrionales.L'approche biologique de la vection a montré la capacité de Phenacoccus aceris à transmettre à la vigne les GLRaV-1, -3, -4, -5, -6, -9 et ceux du bois strié Grapevine virus A et B. Cette étude est la première démonstration de la transmission du GLRaV-6 et confirme l'absence de spécificité des cochenilles dans la transmission

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11

Jooste, Anna Elizabeth Catharina. "Identification and molecular characterization of three genetic variants of Grapevine leafroll-associated virus 3 (GLRaV-3) from South African vineyards and their spread in local vineyards." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6655.

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Thesis (PhD (Genetics))--University of Stellenbosch, 2011.<br>Includes bibliography<br>ENGLISH ABSTRACT: Grapevine diseases, in particular virus and virus-like diseases, are threatening grapevine industries worldwide; also in South Africa. Grapevine leafroll (GLR) is one of the most important diseases of grapevines, occurring in all grape-producing countries worldwide. Grapevine leafroll-associated virus 3 (GLRaV-3) is known to be closely associated with GLR disease and occurs commonly in South African vineyards. In this study three genetic variants of GLRaV-3 were identified in vineyards

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12

Castro, Zavala Adriana 1988. "Effects of maternal separation with early weaning on cocaine addictive behaviour and consequences on neuroplasticity." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670107.

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Early-life stress is associated with maladaptive long-lasting brain effects. Such alterations increase the likelihood of developing several psychiatric disorders. However, the molecular consequences of early-life stress are poorly understood. Here, we evaluated the impact of maternal separation with early weaning (MSEW) at different phases of cocaine self-administration (SA) and the subsequent molecular alterations in brain reward regions of male and female mice. Our findings show that MSEW affects males while females appear to be resilient to this kind of stress. Maternally separated mice evi

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13

El, Aou-ouad Hanan. "Interactive effects of grapevine leafroll associated virus-3 (GLRav-3) and water stress on the gas exchange, water use efficiency, plant hydraulics and metabolism in local grapevine cultivars." Doctoral thesis, Universitat de les Illes Balears, 2017. http://hdl.handle.net/10803/401931.

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Worldwide, agriculture production continues to be constrained by a number of abiotic and biotic stresses. In areas with Mediterranean climate, drought events are expected to strengthen in terms of intensity, frequency and duration in the near future. Thus, in this area, soil water deficit is considered the main environmental factor influencing grapevine growth. At the same time, grapevines are highly subjected to different viruses from which Grapevine leafroll associated virus-3 (GLRaV-3) is one of the most widespread ones, provoking considerable economic losses in many vineyards worldwide. Th

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14

Druart, Mélanie. "Altérations de la connectivité corticale au cours de périodes critiques du développement." Thesis, Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2020SORUS075.pdf.

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Les premières étapes de développement du cerveau dépendent fortement de programmes génétiques. Après la naissance, les connexions neuronales deviennent susceptibles d’être remodelées en réponse à des changements de l’environnement. Cette plasticité culmine au cours de fenêtres temporelles appelées périodes critiques. Les mécanismes sous-jacents sont encore mal connus. Dans le cadre de ma thèse, j’ai étudié les mécanismes qui sous-tendent la plasticité des réseaux au cours de deux périodes critiques chez la souris : la période critique de plasticité de dominance oculaire dans le cortex visuel e

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15

Smit, Nicoleen. "A real-time RT-PCR assay for the detection and quantification of grape-vine leaf-roll-associated virus 3 (GLRa-3) in Vitus vinifera (Vitaceae) and Planococcus ficus (Signoret) (Hemiptera: Pseudococcidae)." Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-10212009-164856.

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16

Patuelli, Claudia. "Implementation, set up and validation of multiplex qualitative two-step RT-PCR based on TaqMan® method for the diagnosis of viruses in Vitis vinifera L." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.

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La viticoltura si trova ad affrontare il problema dalla lotta contro i patogeni che comporta costi ingenti dovuti anche alla sostituzione di piante infette. Le patologie più gravi sono l’Infezione degenerativa, l’Accartocciamento fogliare e il Complesso del legno riccio, tutti causati da infezioni virali. L’impresa cilena Concha y Toro ha deciso di studiare la presenza dei virus all’interno dei propri vigneti in modo da evitarne la diffusione, applicando la tecnica analitica della Real Time PCR, strategia SYBR® Green e TaqMan®. L’obiettivo di questa ricerca è di mettere a punto un protocollo

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17

CHEVALIER, SYLVIE. "Contribution a la detection et a la caracterisation de deux closterovirus, le grapevinevirus a (gva) et le grapevine leafroll-associated virus 1 (glrav 1), agents impliques dans deux maladies de la vigne : les cannelures du tronc et l'enroulement." Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13185.

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Dans cette these sont presentes les travaux visant a ameliorer les conditions de detection de deux closterovirus de la vigne, le virus a (gva) et le virus 1 associe a l'enroulement de la vigne (glrav 1), a demontrer le role du gva dans l'etiologie d'un syndrome de cannelures du tronc, le kober stem grooving (ksg), et a voir des relations entre la multiplication des virus et le niveau d'expression des symptomes de cannelures. Une technique de tres haute sensibilite, basee sur l'amplification genique (pcr) d'un fragment de genome du gva precedee d'une etape d'immunocapture du virus, a ete adapte

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18

Boos, Flávia Zacouteguy. "Reversão dos efeitos reforçadores da morfina através do prejuízo da reconsolidação da memória do condicionamento de preferência por local e da sensibilização locomotora." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/150201.

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A dependência de drogas é um transtorno multifatorial complexo que se desenvolve em uma minoria de indivíduos que fazem uso dessas substâncias. Memórias associativas entre a droga e o contexto funcionam como gatilho para disparar comportamentos não adaptativos de busca e consumo, além de recaídas após períodos de abstinência. Subjacentes a essas mudanças comportamentais, existem modificações nas subunidades de receptores glutamatérgicos do tipo AMPA em estruturas envolvidas com memória (Hipocampo) e recompensa (Núcleo Accumbens). Por isso, estratégias que enfraqueçam a associação do contexto c

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19

Campos, Joana Correia. "Efeito das altas temperaturas de verão observadas no Pólo de Conservação da Videira de Pegões sobre a concentração do vírus do enrolamento foliar da videira tipo 3 (GLRaV3) em seis castas." Master's thesis, 2019. http://hdl.handle.net/10348/9668.

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Dissertação de Mestrado em Engenharia Agronómica<br>A vinha pode ser alvo de várias pragas e doenças parasitárias, entre elas diversas viroses. Atualmente, estão identificados vários vírus responsáveis por algumas dessas patologias da videira embora apenas alguns afetem a sua produtividade, maturação e longevidade. A doença do enrolamento foliar da videira é a virose que está mais expandida pelas vinhas portuguesas, sendo Grapevine leafroll-associated virus 3 (GLRaV3) o mais difundido. Em Pegões está o Pólo de Conservação da Diversidade da Videira da Associação Portuguesa para a Diversidade da

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20

Mikolajewska, Agata [Verfasser]. "Gliom-assoziiertes Antigen 2 (GLEA2) als Immunogen : Aspekte der humoralen und zellulären Immunantwort / vorgelegt von Agata Mikolajewska." 2007. http://d-nb.info/98630932X/34.

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21

Little, Alan. "Complete sequence, improved detection and functional analysis of Grapevine Leafroll-associated Virus 1(GLRaV-1) / by Alan Little." Thesis, 2004. http://hdl.handle.net/2440/22105.

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"April, 2004"<br>"List of figures" - inside back cover.<br>Bibliography: leaves 83-93<br>93, [8] leaves : ill., plates (some col.), photos ; 30 cm.<br>The specific objectives of this work include: 1. Completion of the GLRaV-1 genome sequence and bioinformatic analysis of the viral open reading frames ; 2. Production of an appropriate GLRaV-1 certification protocol addressing the shortcomings of the current tests for leafroll detection ; 3. Intracellular localisation of the GLRaV-1 gene products via generation of green fluorescent protein (GFP)-fusion constructs, in an attempt to further charac

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22

Hanzalová, Jitka. "Vývoj motoriky laboratorního potkana po opakovaném podání antagonisty AMPA receptoru." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-382889.

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Substance IEM 1460 is an antagonist of AMPA receptors in the brain. It is a derivative of adamantine, which has already been tested in several studies as a potential age-related anticonvulsant. In the research part of the thesis there is a summary of the knowledge about receptors, focusing on AMPA receptors, IEM 1460, epilepsy and ontogenetic development of laboratory rat. The research section evaluates the effect of IEM 1460 on motor skills of a rat in a few postnatal days of its life. To evaluate spontaneous animal motor skills, Open-Field tracking was used, and several specific tests were u

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23

Silva, Mariline Mendes. "Unveiling the role of miRNAs in synaptic plasticity." Doctoral thesis, 2018. http://hdl.handle.net/10316/79760.

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Tese de doutoramento em Biologia Experimental e Biomedicina, no ramo de Neurociências e Doença, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra<br>As redes neuronais estão constantemente a adaptar a densidade sináptica e a eficiência da transmissão sináptica em resposta ao normal desenvolvimento neuronal e a processos de aprendizagem. Formas de plasticidade Hebbiana, co mo a potenciação de longo termo ( LTP ) e depressão de longo termo ( LTD ) , são consideradas as fundações celulares da aprendizagem e memória. Esta

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