Journal articles on the topic 'GLP-1R agonists'
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Bloodworth, Melissa Harintho, Jian Zhang, Anne L. Hotard, Martin L. Moore, Tina V. Hartert, Kevin D. Niswender, and R. Stokes Peebles. "Glucagon-like peptide-1 receptor signaling attenuates RSV-induced type 2 responses and immunopathology." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 153.5. http://dx.doi.org/10.4049/jimmunol.198.supp.153.5.
Full textViby, Niels-Erik, Marie S. Isidor, Katrine B. Buggeskov, Steen S. Poulsen, Jacob B. Hansen, and Hannelouise Kissow. "Glucagon-Like Peptide-1 (GLP-1) Reduces Mortality and Improves Lung Function in a Model of Experimental Obstructive Lung Disease in Female Mice." Endocrinology 154, no. 12 (December 1, 2013): 4503–11. http://dx.doi.org/10.1210/en.2013-1666.
Full textAl-Zamel, Noura, Suleiman Al-Sabah, Yunus Luqmani, Lobna Adi, Siby Chacko, Tom Dario Schneider, and Cornelius Krasel. "A Dual GLP-1/GIP Receptor Agonist Does Not Antagonize Glucagon at Its Receptor but May Act as a Biased Agonist at the GLP-1 Receptor." International Journal of Molecular Sciences 20, no. 14 (July 19, 2019): 3532. http://dx.doi.org/10.3390/ijms20143532.
Full textMcKay, Naomi J., Scott E. Kanoski, Matthew R. Hayes, and Derek Daniels. "Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301, no. 6 (December 2011): R1755—R1764. http://dx.doi.org/10.1152/ajpregu.00472.2011.
Full textMaida, Adriano, Julie A. Lovshin, Laurie L. Baggio, and Daniel J. Drucker. "The Glucagon-Like Peptide-1 Receptor Agonist Oxyntomodulin Enhances β-Cell Function but Does Not Inhibit Gastric Emptying in Mice." Endocrinology 149, no. 11 (July 31, 2008): 5670–78. http://dx.doi.org/10.1210/en.2008-0336.
Full textKanoski, Scott E., Samantha M. Fortin, Myrtha Arnold, Harvey J. Grill, and Matthew R. Hayes. "Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4." Endocrinology 152, no. 8 (June 21, 2011): 3103–12. http://dx.doi.org/10.1210/en.2011-0174.
Full textBurcelin, Rémy, Pierre Gourdy, and Stéphane Dalle. "GLP-1-Based Strategies: A Physiological Analysis of Differential Mode of Action." Physiology 29, no. 2 (March 2014): 108–21. http://dx.doi.org/10.1152/physiol.00009.2013.
Full textMalbert, Charles-Henri, Alain Chauvin, Michael Horowitz, and Karen L. Jones. "Pancreatic GLP-1r binding potential is reduced in insulin-resistant pigs." BMJ Open Diabetes Research & Care 8, no. 2 (November 2020): e001540. http://dx.doi.org/10.1136/bmjdrc-2020-001540.
Full textNahmias, Avital, Priska Stahel, Lili Tian, Changting Xiao, and Gary F. Lewis. "GLP-1 (Glucagon-Like Peptide-1) Is Physiologically Relevant for Chylomicron Secretion Beyond Its Known Pharmacological Role." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 6 (June 2021): 1893–900. http://dx.doi.org/10.1161/atvbaha.121.316311.
Full textRode, Anna K. O., Terkild Brink Buus, Veronika Mraz, Fatima Abdul Hassan Al-Jaberi, Daniel Villalba Lopez, Shayne L. Ford, Stephanie Hennen, et al. "Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor." Cells 11, no. 16 (August 19, 2022): 2587. http://dx.doi.org/10.3390/cells11162587.
Full textChang, Rulue, Xin Zhang, Anna Qiao, Antao Dai, Matthew J. Belousoff, Qiuxiang Tan, Lijun Shao, et al. "Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide." Journal of Biological Chemistry 295, no. 28 (May 5, 2020): 9313–25. http://dx.doi.org/10.1074/jbc.ra120.013793.
Full textMorris, Lindsey C., Emily L. Days, Maxine Turney, Dehui Mi, Craig W. Lindsley, C. David Weaver, and Kevin D. Niswender. "A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors." Journal of Biomolecular Screening 19, no. 6 (February 13, 2014): 847–58. http://dx.doi.org/10.1177/1087057114520971.
Full textKawai, Takahiro, Bingfa Sun, Hitoshi Yoshino, Dan Feng, Yoshiyuki Suzuki, Masanori Fukazawa, Shunsuke Nagao, et al. "Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist." Proceedings of the National Academy of Sciences 117, no. 47 (November 11, 2020): 29959–67. http://dx.doi.org/10.1073/pnas.2014879117.
Full textYang, Fan, Xinshang Wang, Jingyu Qi, Kun Zhang, Yongli Jiang, Ban Feng, Tao Lv, et al. "Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice." Nutrients 15, no. 1 (December 21, 2022): 38. http://dx.doi.org/10.3390/nu15010038.
Full textQuarta, Carmelo, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, et al. "GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice." Nature Metabolism 4, no. 8 (August 22, 2022): 1071–83. http://dx.doi.org/10.1038/s42255-022-00617-6.
Full textZhong, Xia, Zhu Chen, Qiong Chen, Wei Zhao, and Zhi Chen. "Novel Site-Specific Fatty Chain-Modified GLP-1 Receptor Agonist with Potent Antidiabetic Effects." Molecules 24, no. 4 (February 21, 2019): 779. http://dx.doi.org/10.3390/molecules24040779.
Full textMadsen, Lars Wichmann, Jeffrey A. Knauf, Carsten Gotfredsen, Andrew Pilling, Ingrid Sjögren, Søren Andersen, Lene Andersen, et al. "GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation." Endocrinology 153, no. 3 (March 1, 2012): 1538–47. http://dx.doi.org/10.1210/en.2011-1864.
Full textVikulova, O. K., Z. T. Zuraeva, O. V. Michaleva, L. V. Nikankina, M. Sh Shamkhalova, M. V. Shestakova, and I. I. Dedov. "Renal effects of glucagon-like peptide receptor agonists in patients with type 1 diabetes mellitus." Terapevticheskii arkhiv 90, no. 6 (June 15, 2018): 59–64. http://dx.doi.org/10.26442/terarkh201890659-64.
Full textLiao, Hui-Jun, and Jason T. C. Tzen. "Investigating Potential GLP-1 Receptor Agonists in Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum, and Drymaria diandra, and Peptides Derived from Heterophyllin B for the Treatment of Type 2 Diabetes: An In Silico Study." Metabolites 12, no. 6 (June 15, 2022): 549. http://dx.doi.org/10.3390/metabo12060549.
Full textMietlicki-Baase, Elizabeth G., Pavel I. Ortinski, Laura E. Rupprecht, Diana R. Olivos, Amber L. Alhadeff, R. Christopher Pierce, and Matthew R. Hayes. "The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors." American Journal of Physiology-Endocrinology and Metabolism 305, no. 11 (December 1, 2013): E1367—E1374. http://dx.doi.org/10.1152/ajpendo.00413.2013.
Full textSun, Lei, Zhi-Ming Zheng, Chang-Sheng Shao, Zhi-Yong Zhang, Ming-Wei Li, Li Wang, Han Wang, Gen-Hai Zhao, and Peng Wang. "Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists." Pharmaceuticals 15, no. 6 (June 13, 2022): 740. http://dx.doi.org/10.3390/ph15060740.
Full textLe, Thao D. V., Dianxin Liu, Sheila Collins, and Julio E. Ayala. "The Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Stimulates Mechanistic Target of Rapamycin (mTOR) Signaling via PKA And Akt." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A510—A511. http://dx.doi.org/10.1210/jendso/bvab048.1044.
Full textKim, Dong Seok, Ho-Il Choi, Yun Wang, Yu Luo, Barry J. Hoffer, and Nigel H. Greig. "A New Treatment Strategy for Parkinson's Disease through the Gut–Brain Axis." Cell Transplantation 26, no. 9 (September 2017): 1560–71. http://dx.doi.org/10.1177/0963689717721234.
Full textHou, Yanan, Stephen A. Ernst, Kaeli Heidenreich, and John A. Williams. "Glucagon-like peptide-1 receptor is present in pancreatic acinar cells and regulates amylase secretion through cAMP." American Journal of Physiology-Gastrointestinal and Liver Physiology 310, no. 1 (January 1, 2016): G26—G33. http://dx.doi.org/10.1152/ajpgi.00293.2015.
Full textSang, Peng, Zhihong Zhou, Yan Shi, Candy Lee, Zaid Amso, David Huang, Timothy Odom, Vân T. B. Nguyen-Tran, Weijun Shen, and Jianfeng Cai. "The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1." Science Advances 6, no. 20 (May 2020): eaaz4988. http://dx.doi.org/10.1126/sciadv.aaz4988.
Full textBurmeister, Melissa A., Jacob D. Brown, Jennifer E. Ayala, Doris A. Stoffers, Darleen A. Sandoval, Randy J. Seeley, and Julio E. Ayala. "The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity." American Journal of Physiology-Endocrinology and Metabolism 313, no. 6 (December 1, 2017): E651—E662. http://dx.doi.org/10.1152/ajpendo.00113.2017.
Full textMartins, Flavia L., Matthew A. Bailey, and Adriana C. C. Girardi. "Endogenous Activation of Glucagon-Like Peptide-1 Receptor Contributes to Blood Pressure Control." Hypertension 76, no. 3 (September 2020): 839–48. http://dx.doi.org/10.1161/hypertensionaha.120.14868.
Full textYusta, Bernardo, Laurie L. Baggio, Jacqueline Koehler, Dianne Holland, Xiemin Cao, Lee J. Pinnell, Kathene C. Johnson-Henry, et al. "GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R." Diabetes 64, no. 7 (March 3, 2015): 2537–49. http://dx.doi.org/10.2337/db14-1577.
Full textNaylor, Jacqueline, Arthur T. Suckow, Asha Seth, David J. Baker, Isabelle Sermadiras, Peter Ravn, Rob Howes, et al. "Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists." Biochemical Journal 473, no. 18 (September 12, 2016): 2881–91. http://dx.doi.org/10.1042/bcj20160476.
Full textTrevaskis, James L., Peter S. Griffin, Carrie Wittmer, Brent A. Neuschwander-Tetri, Elizabeth M. Brunt, Carrie S. Dolman, Mary R. Erickson, James Napora, David G. Parkes, and Jonathan D. Roth. "Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 8 (April 15, 2012): G762—G772. http://dx.doi.org/10.1152/ajpgi.00476.2011.
Full textShaghouli, Amna Ali, Razan Ballani, and Naglaa Mesbah. "Management of Late Dumping Syndrome Induced Hypoglycemia With GLP-1R Agonist." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A416. http://dx.doi.org/10.1210/jendso/bvab048.849.
Full textDiz-Chaves, Yolanda, Manuel Gil-Lozano, Laura Toba, Juan Fandiño, Hugo Ogando, Lucas C. González-Matías, and Federico Mallo. "Stressing diabetes? The hidden links between insulinotropic peptides and the HPA axis." Journal of Endocrinology 230, no. 2 (August 2016): R77—R94. http://dx.doi.org/10.1530/joe-16-0118.
Full textRenner, Éva, Fanni Dóra, Erzsébet Oszwald, Árpád Dobolyi, and Miklós Palkovits. "Elevated Glucagon-like Peptide-1 Receptor Level in the Paraventricular Hypothalamic Nucleus of Type 2 Diabetes Mellitus Patients." International Journal of Molecular Sciences 23, no. 24 (December 15, 2022): 15945. http://dx.doi.org/10.3390/ijms232415945.
Full textCantini, Giulia, Martina Trabucco, Alessandra Di Franco, Edoardo Mannucci, and Michaela Luconi. "Glucagon modulates proliferation and differentiation of human adipose precursors." Journal of Molecular Endocrinology 63, no. 4 (November 2019): 249–60. http://dx.doi.org/10.1530/jme-19-0095.
Full textGreco, Eulalia, Giuseppina Russo, Annalisa Giandalia, Francesca Viazzi, Roberto Pontremoli, and Salvatore De Cosmo. "GLP-1 Receptor Agonists and Kidney Protection." Medicina 55, no. 6 (May 31, 2019): 233. http://dx.doi.org/10.3390/medicina55060233.
Full textXiao, Q., W. Jeng, and MB Wheeler. "Characterization of glucagon-like peptide-1 receptor-binding determinants." Journal of Molecular Endocrinology 25, no. 3 (December 1, 2000): 321–35. http://dx.doi.org/10.1677/jme.0.0250321.
Full textYokomori, Hiroaki, and Wataru Ando. "Spatial expression of glucagon-like peptide 1 receptor and caveolin-1 in hepatocytes with macrovesicular steatosis in non-alcoholic steatohepatitis." BMJ Open Gastroenterology 7, no. 1 (May 2020): e000370. http://dx.doi.org/10.1136/bmjgast-2019-000370.
Full textZhao, He-jun, Xia Jiang, Li-juan Hu, Lei Yang, Lian-dong Deng, Ya-ping Wang, and Zhi-peng Ren. "Activation of GLP-1 receptor enhances the chemosensitivity of pancreatic cancer cells." Journal of Molecular Endocrinology 64, no. 2 (February 2020): 103–13. http://dx.doi.org/10.1530/jme-19-0186.
Full textTsai, Shang-Feng, and Cheng-Hsu Chen. "Management of Diabetes Mellitus in Normal Renal Function, Renal Dysfunction and Renal Transplant Recipients, Focusing on Glucagon-Like Peptide-1 Agonist: A Review Based upon Current Evidence." International Journal of Molecular Sciences 20, no. 13 (June 28, 2019): 3152. http://dx.doi.org/10.3390/ijms20133152.
Full textMori, Yusaku, Takanori Matsui, Tsutomu Hirano, and Sho-ichi Yamagishi. "GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease–A Systematic Review." International Journal of Molecular Sciences 21, no. 4 (February 22, 2020): 1509. http://dx.doi.org/10.3390/ijms21041509.
Full textYang, Zixin, Zhengkun Kuang, Rui Wang, Ni Pi, Xiyao Cheng, Yongqi Huang, and Zhengding Su. "Rational Design of Small Molecular GLP-1R Agonists." Biophysical Journal 120, no. 3 (February 2021): 27a. http://dx.doi.org/10.1016/j.bpj.2020.11.422.
Full textKoch, Linda. "GLP-1R agonists—the new weapon against obesity?" Nature Reviews Endocrinology 8, no. 4 (January 31, 2012): 196. http://dx.doi.org/10.1038/nrendo.2012.13.
Full textZhou, Bilan, Anlin Peng, Hao Gong, and Kun Huang. "GLP-1R agonists therapy for type 2 diabetes." Wuhan University Journal of Natural Sciences 19, no. 1 (January 8, 2014): 27–33. http://dx.doi.org/10.1007/s11859-014-0974-8.
Full textManell, Elin, Emmi Puuvuori, Anna Svensson, Irina Velikyan, Gry Hulsart-Billström, Patricia Hedenqvist, Jens Juul Holst, Marianne Jensen Waern, and Olof Eriksson. "Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography." BMJ Open Diabetes Research & Care 9, no. 1 (April 2021): e002083. http://dx.doi.org/10.1136/bmjdrc-2020-002083.
Full textAngeli, Franca S., and Richard P. Shannon. "Incretin-based therapies: can we achieve glycemic control and cardioprotection?" Journal of Endocrinology 221, no. 1 (August 7, 2013): T17—T30. http://dx.doi.org/10.1530/joe-13-0195.
Full textYaribeygi, Habib, Farin Rashid Farrokhi, Mohammed Altigani Abdalla, Thozhukat Sathyapalan, Maciej Banach, Tannaz Jamialahmadi, and Amirhossein Sahebkar. "The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes." Journal of Diabetes Research 2021 (June 30, 2021): 1–10. http://dx.doi.org/10.1155/2021/6518221.
Full textElabi, Osama F., Jeffrey S. Davies, and Emma L. Lane. "L-dopa-Dependent Effects of GLP-1R Agonists on the Survival of Dopaminergic Cells Transplanted into a Rat Model of Parkinson Disease." International Journal of Molecular Sciences 22, no. 22 (November 16, 2021): 12346. http://dx.doi.org/10.3390/ijms222212346.
Full textHviid, Aleksander Vauvert R., and Charlotte M. Sørensen. "Glucagon-like peptide-1 receptors in the kidney: impact on renal autoregulation." American Journal of Physiology-Renal Physiology 318, no. 2 (February 1, 2020): F443—F454. http://dx.doi.org/10.1152/ajprenal.00280.2019.
Full textChung, Sungjin, and Gheun-Ho Kim. "Use of Anti-Diabetic Agents in Non-Diabetic Kidney Disease: From Bench to Bedside." Life 11, no. 5 (April 25, 2021): 389. http://dx.doi.org/10.3390/life11050389.
Full textFortin, Samantha M., Rachele K. Lipsky, Rinzin Lhamo, Jack Chen, Eun Kim, Tito Borner, Heath D. Schmidt, and Matthew R. Hayes. "GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats." Science Translational Medicine 12, no. 533 (March 4, 2020): eaay8071. http://dx.doi.org/10.1126/scitranslmed.aay8071.
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