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Bazina, Olga. "Development of the institution of the head of state in Taiwan (Republic of China)." OOO "Zhurnal "Voprosy Istorii" 2022, no. 3-1 (March 1, 2022): 26–35. http://dx.doi.org/10.31166/voprosyistorii202203statyi25.
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This article examines the process of formation, development and formation of the institution of the head of state in Taiwan (Republic of China). The process of democratization of the institute of the president in Taiwan.
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Mau, Jens. "Bekenntnis zum Leben." kma - Klinik Management aktuell 15, no. 05 (May 2010): 16. http://dx.doi.org/10.1055/s-0036-1575602.
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Axel Kramer ist führender Kopf der Hygienemedizin in Deutschland – und Lyriker. Fast jeden Abend schreibt der Direktor des Instituts für Hygiene an der Universität Greifswald bei einem Glas Rotwein Gedichte. Daraus ist das Buch „Infragestellung“ entstanden, das jetzt im Georg Thieme Verlag erschienen ist.
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Yasenyavskaya, Anna L., Marina A. Samotrueva, Aleksandra A. Tsibizova, Nikolai F. Myasoedov, and Lyudmila A. Andreeva. "Influence of neuropeptides on psychoemotional state under conditions of “social” stress." Курский научно-практический вестник «Человек и его здоровье», no. 3 (September 2020): 37–45. http://dx.doi.org/10.21626/vestnik/2020-3/05.
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Objective: experimental study of the influence of neuropeptides on the psychoemotional state of white male rats exposed to “social” stress. Materials and methods. A study of the psychomodulatory effect of neuropeptides (Semax, Selank, ACTH(6-9)-Pro-Gly-Pro, Pro-Gly-Pro, Pro-Gly-Pro-Leu) under conditions of experimental “social” stress was performed on white non-linear male rats. The studied neuropeptides were synthesized at the Institute of Molecular Genetics of the National Research Center “Kurchatov Institute”. The study of the effect of neuropeptides on the behavior of male white rats was carried out on the model of “social” stress, the methodological reception of which is the constant residence of animals under conditions of sensory contact in order to form aggressive and submissive types of behavior. The effect of neuropeptides on the psychoemotional state of white rats under conditions of “social” stress was assessed on the basis of studying the behavior of animals in the tests “Elevated сruciform maze” and “Porsolt”. The “Elevated cruciform maze” test makes it possible to study the behavior of animals under conditions of variable stress (with a free choice of comfortable conditions) and allows assessing: the level of anxiety of the animal; symptoms of neurological deficiency. The test “Porsolt” provides an assessment of changes in the motor activity of animals and allows you to study the severity of the depressive state. Results. It was found that the effect of “social” stress on the behavior of male rats contributed to an increase in situational anxiety and the appearance of depressive-like behavioral reactions. It has been proven that the introduction of neuropeptides (Semax, Selank, ACTH(6-9)-Pro-Gly-Pro, Pro-Gly-Pro, Pro-Gly-Pro-Leu) helps to reduce increased anxiety in animals, both with aggressive and submissive types of behavior under conditions of “social” stress thereby providing a psychomodulatory effect. Conclusion. This study expands the understanding of the regulatory role of neuropeptides in the body, demonstrating the possibility of their influence on the psychoemotional state.
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Westley, Tracy, Anna Forsythe, Timothy J. Bell, Joseph C. Cappelleri, Gabriel Tremblay, and Geoffrey Chan. "Clinical Responses of Glasdegibplus Low-Dose Ara-C, Azacitidine, and Decitabine Among Acute Myeloid Leukemia (AML) Patients Ineligible to Receive Intensive Chemotherapy: Comparative Effectiveness Using Indirect Treatment Comparison (ITC) Methods." Blood 132, Supplement 1 (November 29, 2018): 2709. http://dx.doi.org/10.1182/blood-2018-99-111931.
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Abstract OBJECTIVES: Currently there is no standard treatment option for AML patients not fit for intensive chemotherapy. Further clinical challenges include poorer prognosis associated with advanced age. AML treatments among this population have not been directly compared in clinical trials. Furthermore, naïve comparisons of results across multiple trials are subject to bias related to not accounting for within-trial differences from control. Standard (unadjusted) ITC accounts for within-trial efficacy of treatment versus control, providing a valid and robust approach to compare effectiveness between trials. Additionally, simulated treatment comparison (STC) applies ITC methodology and adjusts for differences in population baseline characteristics. Previous ITC and STC of overall survival (OS) demonstrated superiority of combination glasdegib and low-dose ARA-C (GLAS+LDAC) over azacitidine (AZA) or decitabine (DEC). This present study applied ITC and STC of clinical response outcomes between GLAS+LDAC and AZA or DEC among older AML patients unfit for intensive chemotherapy. METHODS: Clinical outcomes for complete remission (CR) and CR plus CR with incomplete blood count recovery (CR+CRi) were indirectly compared between Phase II trial (n=116) GLAS+LDAC individual patient data (IPD) and published Phase III AZA results (n=488), and then between GLAS+LDAC IPD and published Phase III DEC results (n=457). Based on the Decision Support Unit STC guidelines from the National Institute for Health and Care Excellence, GLAS+LDAC IPD regression (which modelled response) was separately adjusted for AZA and DEC patient baseline characteristics. Stepwise models adjusted for key patient covariates and full models adjusted for all patient covariates mutually available between trials including age, sex, having denovo AML or not, bone marrow blast percentage, Eastern Cooperative Oncology Group performance status, cytogenetic risk factors, and hemoglobin level. Between trials, CR and CR+CRi were indirectly compared by standard ITC and STC using risk ratios (RR) with 95% confidence intervals (CIs). RESULTS: Naïve comparisons of CR [GLAS+LDAC (17.95%), AZA (19.50%), and DEC (15.70%)] and CR+CRi [GLAS+LDAC (24.36%), AZA (27.80%), and DEC (25.62%)] favored AZA. However, based on each of the three modelling techniques (standard ITC, STC full covariate adjustment, STC stepwise adjustment), GLAS+LDAC showed superiority over AZA. Compared with AZA, standard ITC estimated that GLAS+LDAC patients were over seven and four times as likely to reach CR [RR=7.67 (1.02, 57.87)] and CR+CRi [RR=4.33 (1.02, 18.29)], respectively. Using STC full covariate adjustment, GLAS+LDAC patients compared with AZA were over nine times as likely to reach CR [RR=9.63 (0.81, 113.95)] and over four times as likely to reach CR+CRi [RR=4.45 (1.01, 19.59)]. In the stepwise STC approach, GLAS+LDAC versus AZA similarly improved the likelihood of CR [RR=8.76 (1.13, 68.21)] and CR+CRi [RR=4.42 (1.04, 18.87)]. Comparing GLAS+LDAC to DEC, standard (unadjusted) ITC found numeric but not statistically significant improvement in CR [RR=3.43 (0.44, 27.00)] and CR+CRi [RR=1.94 (0.45, 8.43)]. STC methods for GLAS+LDAC versus DEC yielded trends similar to ITC. Non-significant trends in numeric favor of GLAS+LDAC were found using both full covariate adjustment [CR, RR=4.31 (0.36, 52.32); CR+Cri, RR=2.00 (0.46, 8.73)] and stepwise adjustment [CR, RR=3.41 (0.28, 41.94); CR+CRi, RR=1.97 (0.45, 8.65)]. CONCLUSIONS: In the absence of clinical trials directly testing less intensive AML treatments, indirect comparison methods apply statistically robust techniques versus naïve comparisons to measure comparative effectiveness. Regarding the likelihood of response to treatment, GLAS+LDAC showed improvement over AZA or DEC. As previously found when comparing OS, both ITC and STC estimated GLAS+LDAC superiority over AZA for both CR and CR+CRi. For GLAS+LDAC versus DEC, ITC and STC found numerical improvement in CR and CR+CRi; however, these treatments were not statistically significant for each of the two response outcomes. Figure 1. ITC and STC results for GLAS+LDAC versus AZA or DEC Figure 1. Figure 1. Disclosures Forsythe: Novartis: Consultancy. Bell:Pfizer: Employment, Equity Ownership. Cappelleri:Pfizer: Employment, Equity Ownership. Chan:Pfizer: Employment, Equity Ownership.
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Faraj, Ghazal, and András Micsik. "Persons, GLAM institutes and collections: an analysis of entity linking based on the COURAGE registry." International Journal of Metadata, Semantics and Ontologies 15, no. 1 (2021): 39. http://dx.doi.org/10.1504/ijmso.2021.10040247.
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Faraj, Ghazal, and András Micsik. "Persons, GLAM institutes and collections: an analysis of entity linking based on the COURAGE registry." International Journal of Metadata, Semantics and Ontologies 15, no. 1 (2021): 39. http://dx.doi.org/10.1504/ijmso.2021.117105.
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Mączyńska, Agnieszka, Mariola Głazek, and Barbara Krzyzińska. "Effect of foliar fertilizer and fungicidal protection against leaf spot diseases on winter wheat." Acta Agrobotanica 58, no. 1 (2012): 51–58. http://dx.doi.org/10.5586/aa.2005.008.
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Field experiments were carried out in the seasons 2000/2001 and 2001/2002 in Plant Protection Institute, Sooenicowice Branch to assess the influence of foliar fertilizers such as Ekolist PK 1, Ekolist Mg, Mikrosol Z and Urea on healthiness of winter wheat. Foliar fertilizers were mixed with fungicides. The fungicides were applied at full or half recommended doses. The effect of the disease on wheat leaves was evaluated three times in each vegetation season. Remaining green leaf area (GLA) of leaves was also determined. GLA of the leaves F-1 was not significantly different for each combination with different fertilization and different levels of chemical treatment. The application of foliar fertilizer only had no effect on green leaf area (GLA). The results indicate that foliar fertilization of all experimental plots improved leaf condition and therefore halted the development of wheat leaf diseases. The increases of 1000 grain mass and yield was high for each plot where a fertilizer and a full or half dose of a fungicide was applied. Foliar fertilizing with no chemical control had no proven effect on studied parameters.
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Westley, Tracy, Anna Forsythe, Timothy J. Bell, Joseph C. Cappelleri, Geoffrey Chan, and Gabriel Tremblay. "Comparative Effectiveness of Combination Glasdegib+ Low-Dose Cytarabine (GLAS+LDAC) Vs Combination Venetoclax + Low-Dose Cytarabine (VEN+LDAC) Among Older Acute Myeloid Leukemia (AML) Patients Ineligible for Intensive Chemotherapy (NIC): Indirect Treatment Comparison (ITC) Methods." Blood 132, Supplement 1 (November 29, 2018): 1429. http://dx.doi.org/10.1182/blood-2018-99-111971.
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Abstract BACKGROUND: Older AML patients are often NIC and face poorer prognoses. Among less intensive AML treatments, GLAS+LDAC showed improved efficacy vs LDAC alone in a Phase II randomized controlled trial (RCT). Recently, a phase I/II single arm study of VEN+LDAC showed longer overall survival (OS) in naive comparison to GLAS+LDAC. However, naïve comparisons across trials do not account for within-trial efficacy differences from control or different population characteristics. In the absence of clinical trials comparing GLAS+LDAC vs VEN+LDAC, ITC is a more robust approach, and simulated treatment comparison (STC) adjusts for between-trial differences in patient baseline characteristics. In this study, GLAS+LDAC and VEN+LDAC were indirectly compared for survival efficacy using both ITC and STC. METHODS: Median OS and proportion of patients alive at 12 months (12-month OS) were compared for GLAS+LDAC vs VEN+LDAC using individual patient-level data (IPD) for GLAS+LDAC (n=116) and published results for VEN+LDAC (n=61). As the VEN+LDAC study lacked a control group, ITC and STC methods followed the unanchored, single-arm comparison as guided by the National Institute of Health and Care Excellence Decision Support Unit. Mean differences (MD) in median OS (months) between treatments were estimated using a modified Bucher ITC approach with 95% confidence intervals (CI). For 12-month OS, significance tests for MDs between treatments were conducted in Stata (MD with 95% CI). While ITC did not adjust for patient characteristics, using STC, GLAS+LDAC IPD were adjusted for VEN+LDAC patient baseline covariates. Full models included mutually reported covariates between trials, adjusting for GLAS+LDAC patients being older, having less denovo AML, higher bone marrow blasts, worse ECOG performance status, poorer cytogenetic risk, and more males compared to VEN+LDAC patients. STC models were estimated both with and without proportional hazards (PH) assumptions, and the best fitting models were applied. RESULTS: In the naive comparison, GLAS+LDAC had shorter median OS (8.3 months) vs VEN+LDAC (11.4 months). Similarly, 12-month OS was lower for GLAS+LDAC (39.4%) vs VEN+LDAC (45.9%). ITC found non-significant differences between GLAS+LDAC and VEN+LDAC for median OS [MD=-3.09 (-9.34, 3.17)] and 12-month OS [MD=-0.07 (-0.23, 0.10)], with numeric trends favoring VEN+LDAC (as shown in the Table). With full STC adjustment, PH models showed numeric but not statistical superiority of GLAS+LDAC vs VEN+LDAC for median OS [e.g., Gompertz-derived MD=0.60 (-4.43, 5.62)]. In contrast, full covariate models without the PH assumption estimated numeric but not statistical superiority of VEN+LDAC [e.g., lognormal-derived MD=-0.50 (-5.52, 4.51)]. Stepwise model results reflected full covariate adjustments: PH models numerically favored GLAS+LDAC over VEN+LDAC by about one month [e.g., exponential-derived MD=0.89 (-4.13, 5.90)]. Among models relaxing the PH assumption, the gamma estimate numerically favored GLAS+LDAC over VEN+LDAC [MD=0.39 (-4.63, 5.41)]. For 12-month OS, with all STC approaches, differences between GLAS+LDAC and VEN+LDAC were not statistically significant. After full covariate adjustment, slight numeric improvement with GLAS+LDAC vs VEN+LDAC was found for PH models [e.g., Gompertz-derived MD=0.04 (-0.13, 0.21)] and non-PH models [e.g., lognormal-derived MD=0.01 (-0.16, 0.17)]. Stepwise covariate models generated highly similar results (data not shown). CONCLUSIONS: Although GLAS+LDAC and VEN+LDAC have not been directly compared in a clinical trial, ITC and STC approaches found no difference between the two treatments comparing median OS and 12-month OS. Moreover, indirect approaches may introduce less bias than naïve comparisons, as methods can include statistical testing of differences and adjusting for population baseline differences. Standard ITC, which account for within-trial improvements from placebo could not be performed due to the single-arm design of the VEN+LDAC study. Furthermore, single-arm, open-label trials such as the VEN+LDAC study may overestimate treatment effectiveness, and GLAS+LDAC estimates originated from a robustly conducted RCT. As there was no evidence of statistical differences between treatments, health care stakeholders should continue to prioritize RCT evidence generation and minimize inferences from naïve comparisons. Disclosures Forsythe: Novartis: Consultancy. Bell:Pfizer: Employment, Equity Ownership. Cappelleri:Pfizer: Employment, Equity Ownership. Chan:Pfizer: Employment, Equity Ownership.
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Stigler, Johannes, and Helmut W. Klug. "KONDE - Ein Netzwerk bringt Forschungs- und GLAM-Institutionen zusammen. Ein Projektbericht." Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare 72, no. 2 (September 17, 2019): 431–39. http://dx.doi.org/10.31263/voebm.v72i2.3048.
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Seit Frühjahr 2017 läuft als Hochschulraum-Strukturmittel-Projekt das „Kompetenznetzwerk Digitale Edition“ (KONDE), das sich den Prämissen der Open Science Community verpflichtet fühlt und darauf zielt, Voraussetzungen für die Etablierung einer nachhaltigen, nationalen Publikationsplattform für Digitale Editionen (DE) für geistes-, sozial- und kulturwissenschaftliche Disziplinen (GSK) zu schaffen. Beiträger*innen der Universitäten Graz, Innsbruck, Klagenfurt, Salzburg und Wien, sowie der Technischen Universität Graz und der Kunstuniversität Graz, gemeinsam mit Fachkolleg*innen der Österreichischen Nationalbibliothek, der Österreichischen Akademie der Wissenschaften und des Adalbert Stifter-Instituts des Landes Oberösterreich haben sich das Ziel gesetzt, eine Forschungsinfrastruktur für Digitale Editionen aufzubauen und österreichweit vorhandene Kompetenzen in diesem Bereich zu bündeln. Diese Infrastruktur soll keinesfalls nur als Hardware-Lösung oder Sammlung technischer Lösungsansätze verstanden werden, sondern möchte das Thema DE auch aus methodisch-theoretischer Sicht systematisch aufarbeiten und die Arbeits- und Diskussionsergebnisse der einschlägigen Scientific Community in einem interaktiven Weißbuch „Digitale Edition“ zur Verfügung stellen.
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Thalacker-Mercer, Anna, Jamie Blum, and Brandon Gheller. "Serine and Glycine Are Essential for Skeletal Muscle Regeneration Following Injury." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 81. http://dx.doi.org/10.1093/cdn/nzaa040_081.
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Abstract Objectives Skeletal muscle (SkM) regeneration post injury is reliant on SkM-specific stem cells (muscle progenitor cells [MPCs]) and a well-orchestrated myogenic program. The regenerative process is impaired with advancing age, potentiating pathological SkM remodeling (infiltration of fat and fibrotic tissues). We have previously demonstrated that the nutritionally non-essential amino acids serine (Ser) and glycine (Gly) are required for early stages of SkM regeneration (MPC proliferation). However, Ser and Gly availability (SkM and circulating) declines with aging. The objective was to test the hypothesis that reduced endogenous Ser/Gly during regeneration promotes pathological SkM remodeling in aged animals. Methods Old mice (∼20 months of age) were given a Ser/Gly depleted diet (SGdep) or an isonitrogenous, isoenergetic diet containing Ser/Gly (SGcont) for 4 weeks followed by notexin-induced injury to the tibialis anterior (TA) SkM. At 28 days post injury the TA was harvested and histological analysis of SkM morphology (H&E and immunofluorescence [IF]) and gene expression analyses (qPCR) were completed. Results Old mice receiving the SGdep diet had a shift toward reduced myofiber size and enhanced adipocyte infiltration in the SkM. Adipocyte infiltration was confirmed with IF of perilipin-1, an adipocyte marker. Uninjured mice on the SGdep diet did not demonstrate altered SkM morphology. Gene expression analysis of differentially expressed genes underlying SkM remodeling (reduced myofiber size and increased fat infiltration) with SGdep is ongoing. Conclusions Reduced Ser and Gly availability following injury instigates SkM remodeling in old mice, which could explain in part age-related impairments in SkM regeneration. This research underscores the essentiality of Ser and Gly for the SkM regenerative process particularly with advancing age. Funding Sources Canadian Institutes of Health Research Doctoral Foreign Study Award to BG.
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Shi, Junchao, Massimo Menenti, and Roderik Lindenbergh. "Parameterization of Surface Roughness Based on ICESat/GLAS Full Waveforms: A Case Study on the Tibetan Plateau." Journal of Hydrometeorology 14, no. 4 (August 1, 2013): 1278–92. http://dx.doi.org/10.1175/jhm-d-12-0130.1.
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Abstract Glaciers in the Tibetan mountains are expected to be sensitive to turbulent sensible and latent heat fluxes. One of the most significant factors of the energy exchange between the atmospheric boundary layer and the glacier is the roughness of the glacier surface. However, methods to parameterize this roughness for glacier surfaces in remote regions are not well known. In this paper, the authors use the data acquired by Ice, Cloud, and Land Elevation Satellite (ICESat)/Geoscience Laser Altimeter System (GLAS) laser altimetry from February 2003 to November 2004 along several tracks over glaciers of the Nyainqêntanglha range in central Tibet. The authors make a study of the waveforms measured by the ICESat/GLAS laser system over mountainous and glacial areas. The surface characteristics are evaluated within laser footprints over the glacier outlines based on the glaciological inventory of the Tibetan Plateau constructed by the Cold and Arid Regions Environmental and Engineering Research Institute (CAREERI), Chinese Academy of Sciences. For this purpose, the authors extract waveform parameters: the waveform width, the number of modes, and the RMS width of the waveform. These parameters are compared with surface slope and roughness obtained from the Advanced Spaceborne Thermal Emission and Reflection Radar (ASTER) Global Digital Elevation Model (GDEM). Through this analysis, the impact of morphology on the returned laser waveform is shown for the Nyainqêntanglha range. The roughness and the slope of the surface can be quite significant and may contribute from several meters to tens of meters to the pulse extent. The waveform analysis results indicate that the received waveforms are capable representations of surface relief within the GLAS footprints.
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Tremblay, Gabriel, Patrick Daniele, Mike Dolph, Timothy J. Bell, Geoffrey Chan, Andrew Brown, and Joseph C. Cappelleri. "Comparative Effectiveness of Glasdegib or Venetoclax in Combination with Low-Dose Cytarabine Using Simulated Treatment Comparisons." Blood 136, Supplement 1 (November 5, 2020): 17–18. http://dx.doi.org/10.1182/blood-2020-137641.
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Background: Older patients with acute myeloid leukemia (AML) who are unfit for intensive chemotherapy have a poor prognosis, further encumbered by the lack of well-tolerated standard therapies. Combinations of glasdegib with low-dose cytarabine (GLAS+LDAC) and venetoclax with LDAC (VEN+LDAC) are non-intensive chemotherapy (NIC) options recommended by the National Cancer Comprehensive Network Guidelines. As these regimens have not been compared in a head-to-head trial, indirect treatment comparisons (ITC) are of clinical relevance to assess their comparative effectiveness. Hazard ratios (HR) for overall survival (OS) estimate relative survival valued equally throughout follow-up, unlike landmark measures of OS, which may overvalue or undervalue survival at a single time point. This simulated treatment comparison (STC) study compared OS HRs between GLAS+LDAC and VEN+LDAC among older patients with AML unfit for IC. Methods: This analysis utilized individual AML patient data (IPD) from the BRIGHT AML 1003 GLAS+LDAC trial (N=116) and published summary data extracted from the Phase III VEN+LDAC trial (N=211). STC was used following Decision Support Unit Guidelines from the National Institute for Health and Care Excellence. Parametric time-to-event regression models for OS were generated using the GLAS+LDAC IPD; optimal exponential models are presented based on fit statistics. OS HRs were estimated after adjusting for baseline patient characteristics of the GLAS+LDAC trial to match the VEN+LDAC trial. Full and backwards stepwise models (retention p-value <0.2) were constructed considering all mutually available patient covariates including age, sex, de novo vs secondary AML, bone marrow blast >50%, Eastern Cooperative Oncology Group performance status, and cytogenetic risk. OS HRs were indirectly compared by ITC (unadjusted for covariates) and STC (adjusted) with 95% confidence intervals (CIs). ITC and STC used post-hoc analysis results for VEN+LDAC; a sensitivity analysis of pre-specified analysis results for VEN+LDAC was conducted. Results: Overlapping Kaplan Meier (KM) curves for GLAS+LDAC and VEN+LDAC (Figure 1A) suggest that survival probability was similar throughout follow-up. Comparisons of crude survival rates, however, do not account for differences in patient characteristics between studies. Patients in the GLAS+LDAC trial were more likely to be male, have secondary AML, and had worse cytogenetic risk profiles than the VEN+LDAC trial. Unadjusted ITC estimated that GLAS+LDAC numerically (but not statistically) favored over VEN+LDAC, with a 34% (HR: 0.66; 95%CI: 0.38, 1.15) reduction in mortality (Figure 1B). Similarly, following STC with full covariate adjustment, the estimated comparative advantage of GLAS+LDAC over VEN+LDAC widened to 44% (HR: 0.56; 95%CI: 0.24, 1.31). Results of the sensitivity analyses were consistent with these findings. Conclusion: This study indirectly compared OS HRs of GLAS+LDAC and VEN+LDAC in older patients with AML unfit for intensive chemotherapy. In the absence of a head-to-head trial, a well-conducted STC provides the best adjusted estimate of comparative effectiveness between treatments. Unadjusted ITC and adjusted STC revealed that the OS HR numerically favored GLAS+LDAC over VEN+LDAC, albeit not significantly. These findings suggest that the decision between these two recommended NIC regimens may not be based solely on differences in survival outcomes. Rather, the safety profile, the burden of administration, and patient preference will need to be factored into treatment decisions. Figure 1. KM and ITC/STC Results Figure 1 Disclosures Tremblay: Pfizer Inc.: Consultancy; Purple Squirrel Economics: Current Employment. Daniele:Purple Squirrel Economics: Current Employment; Pfizer Inc: Consultancy. Dolph:Purple Squirrel Economics: Current Employment; Pfizer Inc: Consultancy. Bell:Pfizer: Current Employment, Current equity holder in publicly-traded company. Chan:Pfizer Inc.: Current Employment. Brown:Pfizer: Current Employment, Current equity holder in publicly-traded company. Cappelleri:Pfizer Inc.: Current Employment.
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Li, G., X. Tang, X. Yuan, P. Zhou, and F. Hu. "VERTICAL ACCURACY ASSESSMENT OF ZY-3 DIGITAL SURFACE MODEL USING ICESAT/GLAS LASER ALTIMETER DATA." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-1/W1 (May 30, 2017): 23–28. http://dx.doi.org/10.5194/isprs-archives-xlii-1-w1-23-2017.
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The Ziyuan-3 (ZY-3) satellite, as the first civilian high resolution surveying and mapping satellite in China, has a very important role in national 1&thinsp;:&thinsp;50,000 stereo mapping project. High accuracy digital surface Model (DSMs) can be generated from the three line-array images of ZY-3, and ZY-3 DSMs of China can be produced without using any ground control points (GCPs) by selecting SRTM (Shuttle Radar Topography Mission) and ICESat/GLAS (Ice, Cloud, and land Elevation Satellite, Geo-science Laser Altimeter System) as the datum reference in the Satellite Surveying and Mapping Application Center, which is the key institute that manages and distributes ZY-3 products. To conduct the vertical accuracy evaluation of ZY-3 DSMs of China, three representative regions were chosen and the results were compared to ICESat/GLAS data. The experimental results demonstrated that the root mean square error (RMSE) elevation accuracy of the ZY-3 DSMs was better than 5.0&thinsp;m, and it even reached to less than 2.5&thinsp;m in the second region of eastern China. While this work presents preliminary results, it is an important reference for expanding the application of ZY-3 satellite imagery to widespread regions. And the satellite laser altimetry data can be used as referenced data for wide-area DSM evaluation.
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Bordoloi, Jijnasa, Jatin Kalita, and Prasenjit Manna. "Vitamin K Stimulates Gas6 Carboxylation and Inhibits Hyperlipidemia Associated Hepatic Inflammation via Arresting Monocyte-Hepatocyte Adhesion." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1781. http://dx.doi.org/10.1093/cdn/nzaa067_008.
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Abstract Objectives Vitamin K (VK), an important antihemorrhagic vitamin has attracted scientific attention recently due to its diverse physiological activities beyond hemostasis. Present study for the first time systematically examined the hypothesis that circulating VK deficiency might be linked with hyperlipidemia-associated inflammatory pathophysiology and VK supplementation may ameliorate the hepatic inflammation via activating growth arrest specific 6 (Gas6) protein, an important member of the coagulation-unrelated vitamin K-dependent proteins. Methods Subjects with hyperlipidemia (n = 22) and age-matched healthy controls (n = 19) attending the institute clinical center were included in this study. High fat diet (HFD)-fed male albino mice model was used for in vivo studies. High palmitic acid (PA, 0.75 mM)-treated and GGCX knockdown monocytes and hepatocytes were employed for in vitro studies. All data were analyzed using Sigma Stat statistical software. Results Plasma levels of VK and Gla-Gas6 were significantly lower and intercellular adhesion molecule-1 (ICAM-1) was remarkably higher in hyperlipidemic subjects compared to control. Correlation studies showed that both circulatory Gla-Gas6 and VK levels were significantly and inversely correlated with ICAM-1. Interestingly, Gla-Gas6 was positively correlated with plasma VK, which suggests that VK supplementation may ameliorate the hyperlipidemia-induced inflammation via activating Gas6. Further studies with HFD-fed hyperlipidemic animals demonstrated that VK supplementation dose-dependently reduced the hepatic expression of pro-inflammatory cytokines while elevating the plasma level of Gla-Gas6 in HFD-fed mice. In vitro studies showed that VK supplementation prevented the high PA-induced hepatic inflammation in a dose-dependent manner. Furthermore, the knockdown study established the direct role of Gla-Gas6 in mediating the positive effect of VK on the management of PA-induced hepatic inflammation. Conclusions Combining all, the present study demonstrated the beneficial effect of VK supplementation on the management of hyperlipidemia-associated inflammatory events via activating VK-dependent Gas6 protein. Funding Sources Junior research fellowship to JB & Ramalingaswami fellowship to PM by DBT, Govt. of India.
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Medvedev, Dmitry A. "Introducing our new Editorial Board Members." Chimica Techno Acta 9, no. 4 (July 28, 2022): 202294E. http://dx.doi.org/10.15826/chimtech.2022.9.4.e.
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The Chimica Techno Acta (CTA) journal was established in 2014. Since then, CTA has grown into a recognized platform for reporting recent advances in engineering chemistry. We would like to express our deep appreciation to all our authors, reviewers and readers, whose valuable participation has contributed greatly to the current level of CTA.One year ago, in a desire to further enhance the journal’s visibility and impact, a number of important changes were initiated, such as visual redesigning of the journal’s website, updating editorial policies and clarifying the Aims Scope. More importantly, we undertook a step towards expanding our Editorial Board team. As a result of this initiative, we are glad to welcome Prof. Ekaterina Kozlova from the Boreskov Institute of Catalysis and Dr. Farid Orudzhev from the Immanuel Kant Baltic Federal University as our new Editorial Board Members.
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Grant, Alan, Paul Williams, Nick Ward, and Sally Basker. "GPS Jamming and the Impact on Maritime Navigation." Journal of Navigation 62, no. 2 (March 12, 2009): 173–87. http://dx.doi.org/10.1017/s0373463308005213.
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Versions of this paper were first presented at the Royal Institute of Navigation GNSS Vulnerabilities and Solutions Conference held at Baska, Croatia in September 2008 and the Royal Institute of Navigation NAV 08 Conference held at Church House, Westminster, London in October 2008.The US Global Positioning System (GPS) is currently the primary source of Position, Navigation and Timing (PNT) information in maritime applications, whether stand-alone or augmented with additional systems. This situation will continue in the future with GPS, possibly together with other Global Navigation Satellite Systems (GNSS) e.g. Galileo, being the core PNT technology for e-Navigation – the future digital maritime architecture. GPS signals, measured at the surface on the Earth, are very weak. As such, the system is vulnerable to unintentional interference and jamming, resulting in possible denial of service over large geographical areas. The result of such interference could be the complete failure of the mariner's GPS receiver or, possibly worse, the presentation to the mariner of hazardously misleading information (HMI) for navigation and situational awareness, depending on how the GPS receiver reacts to the jamming incident. Recognising this, the General Lighthouse Authorities of the United Kingdom and Ireland (GLA), in collaboration with the UK Ministry of Defence (MOD) Defence Science and Technology Laboratory (DSTL), have conducted a series of sea-trials with the aim of identifying the full effects of GPS jamming on safe navigation at sea.This paper presents the key findings of these trials and provides important information on the effect of GPS denial. The GLA are playing a pivotal role in the establishment of eLoran as an independent source of PNT, taking advantage of eLoran's complementary nature, having dissimilar failure modes to GPS and the future GNSS. This paper provides information on the performance of an eLoran receiver in an area of GPS service denial. The paper presents the rationale for the work, details the system architecture employed, the data gathering efforts and finally the data analysis procedures, results and conclusions.
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Woodall, Alan A., David B. Menkes, Thomas R. Trevelyan, and Colin P. Lanceley. "A study of clozapine and long-term hospitalisation rates." Psychiatric Bulletin 28, no. 8 (August 2004): 285–88. http://dx.doi.org/10.1192/pb.28.8.285.
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Aims and MethodThe aim of the study was to investigate the use of clozapine in treatment-resistant schizophrenia and its impact on hospitalisation rates when prescribed in accordance with National Institute for Clinical Excellence (NICE) guidelines. Case records were examined of patients admitted to the psychiatric unit of Glan Clwyd Hospital between 1996 and 2001.ResultsOf 59 patients identified as having treatment-resistant schizophrenia, 83% had been considered for clozapine, 48% were taking clozapine, 20% had refused the drug and 15% had stopped taking it because of side-effects. The mean annual hospitalisation rate for patients receiving clozapine for a minimum of 3 years was 13.5 days, markedly lower than those not receiving this drug (34.0 days, P=0.03). Older patients were less likely to have been offered clozapine (P=0.006).Clinical ImplicationsThis study supports the NICE guidelines recommending clozapine for patients with treatment-resistant disease. Clozapine is offered less often to older patients; factors influencing this require investigation.
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Dennis, Kristine, Ken Liu, Young-Mi Go, and Dean Jones. "Impact of Food Processing on Concentrations of Metal-Binding Phytochelatins in Plant-Based Food." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 748. http://dx.doi.org/10.1093/cdn/nzaa052_017.
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Abstract Objectives Phytochelatins (PyCs), plant-derived metal-binding compounds, are widely found in plants and thought to impact absorption of metals. Our objective was to assess the impact of food processing on PyC concentrations in a set of commonly consumed plant foods in the U.S. population. Methods Plant food types were selected using USDA's Food Consumption data, purchased from local grocery stores, and selected to ensure a variety of processing levels including canned, frozen, and fresh. Carrot, corn, potato, spinach, tomato and pea samples were ground, extracted, and analyzed using an optimized LC-MS/MS method for PyC detection. PyC concentrations were calculated using single-point calibration with authentic standards. Quantifiable PyCs were compared using Student's t-test within each food type by processing level (e.g., canned vs. fresh). Additional comparisons of processing categories were completed when sample size allowed (minimum n = 3 per processing category). Results PyC2-Gly levels were lower in canned versus frozen or fresh carrots, corn, and peas but not potatoes, spinach or tomatoes (carrots: 1.92 ± 1.39 vs. 8.26 ± 1.43; corn: 1.01 ± 0.73 vs. 9.39 ± 2.88; peas: 0.46 ± 0.09 vs. 1.46 ± 0.19 µg/g fresh weight; mean ± SEM, Student's t-test, P < 0.05). In subanalyses of peas (canned vs. fresh; canned vs. frozen; frozen vs. fresh), PyC2-Gly concentrations differed (canned: 0.46 ± 0.09; frozen: 1.15 ± 0.16; fresh: 1.89 ± 0.20 µg/g fresh weight; P < 0.05). Of the four foods with quantifiable PyC3-Gly (corn, potato, tomato, peas), only corn had lower PyC3-Gly levels in flour or canned versus frozen or fresh (0.0014 ± 0.0011 vs. 0.45 ± 0.19 µg/g fresh weight). PyC2-Ala was quantifiable in peas and corn but did not differ by processing level. Conclusions PyC levels were different by level of processing in some foods with higher PyC concentrations in less processed (i.e., fresh or frozen) foods. Evidence suggests PyCs may protect from absorption of dietary toxic metals such as cadmium. Dietary patterns emphasizing less processed plant foods may contain higher PyC concentrations and offer protection from toxic metals present in the diet. Funding Sources National Institute of Environmental Health Sciences.
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Kumar, D. Dev, V. Padma, H. S. Talwar, and Farzana Jabeen. "The Value of the Stay-green Traits with Grain Yield of Post Flowering Drought Tolerance in Rabi Sorghum." International Journal of Bio-resource and Stress Management 12, no. 1 (February 28, 2021): 059–63. http://dx.doi.org/10.23910/1.2021.2153.
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An experiment was conducted during rabi 2012-13 at research farm of Indian Institute of Millet Research (IIMR), Rajendranagar, Hyderabad, Telengana State, India. The experiment was laid out in a split plot design, replicated thrice, with 10 Sorghum genotypes as main treatment Well-watered (WW) and Water-stress (WS) conditions) to examine the potential of Sorghum genotypes to adapt to the post flowering drought. 10 genotypes are sub-treatments CRS 4, CRS 19, CRS 20, PEC 17, CSV 18, M 35-1, Phule chitra, Phule moulee, EP 57 and CRS 1). Among the four stages viz., 10, 20, 30 and 40 days after flowering (DAF), the GLAR (stay green trait) at 10 DAF had a positive and higher significant correlation with grain yield (r=0.66). So, GLAR at 10 DAF is most appropriate stage to screen for post flowering drought tolerance. Among the yield components, number of grains per panicle, grain weight panicle-1 and harvest index (HI) are significantly and positively correlated with grain yield and therefore it can be ascribed that the genotypes, which partitioned more assimilates into economic parts and in which grain filling is high, recorded more grain yield. The overall yield reduction due to moisture stress during the post flowering drought was 10% and it ranged between 8-12% among the genotypes. This indicates that the genotypes used in the present study are relatively drought tolerant. The genotypes CSV 18 and Phule moulee registered least yield reduction (8%) in grain yield due to post flowering drought followed by PEC 17 and M 35-1 which registered 9% yield reduction. However, the overall grain yield of PEC 17 and M 35-1 was more than CSV 18 and Phule moulee even under moisture stress conditions.
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Nakagawa, L. E., and M. M. Andréa. "Liberação de resíduos ligados de atrazina de solos por meio de esterilização por autoclavagem e radiação gama." Revista Brasileira de Ciência do Solo 21, no. 4 (December 1997): 707–10. http://dx.doi.org/10.1590/s0100-06831997000400023.
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Para estudar a influência de microrganismos nos processos de dissipação de pesticidas em solos, os métodos de esterilização são, particularmente, importantes. Este trabalho, realizado nos laboratórios do Instituto Biológico de São Paulo, em agosto de 1996, avaliou a influência de dois métodos de esterilização de solo - calor úmido (autoclavagem) e radiação γ - no processo de liberação de resíduos ligados. Tomaram-se, como exemplos, resíduos ligados do herbicida atrazina em dois tipos de solo (gley húmico e latossolo vermelho-escuro). Nas amostras de solo submetidas à esterilização por calor úmido, a recuperação dos resíduos previamente ligados como resíduos reextraíveis foi de 5,0 e 5,9 vezes superior à dos controles, não submetidos a qualquer processo de esterilização. Portanto, o próprio método de esterilização liberou os resíduos, o que indica que, para estudar a influência de microrganismos na liberação de resíduos ligados, a autoclavagem não é o método mais adequado. Por outro lado, verificou-se que a radiação γ não alterou a recuperação dos resíduos em relação aos controles.
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Kachkovska, V. V., and L. N. Prystupa. "ANALYSIS OF THE ASSOCIATION OF BRONCHIAL ASTHMA CLINICAL COURSE WITH Arg16Gly POLYMORPHIC VARIANT IN THE β2-ADRENOCEPTOR GENE." Medical Science of Ukraine (MSU) 17, no. 2 (June 30, 2021): 70–76. http://dx.doi.org/10.32345/2664-4738.2.2021.10.
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Relevance. The relevance of the study of Arg16Gly polymorphism of the β2-adrenoceptor (β2-AR) gene is due to the fact that a number of studies have proven its role in the development of bronchial asthma (BA), bronchial hyperactivity, the effectiveness of basic treatment. However, these associations show low reproducibility in various studies, so the question of the possibility of clinical application of the results of genetic testing for Arg16Gly polymorphic variant of the β2-AR gene remains unanswered. The main reasons why the clinical significance of this polymorphism is not confirmed in various studies are - population heterogeneity, insufficient sample size, improper characterization of comparison groups.
Objective: to study the association of Arg16Gly polymorphism in the β2-adrenoceptor gene with BA clinical course taking into account the age of onset.
Materials and methods. We examined 553 BA patients (group I included 282 patients with late-onset asthma and group II included 271 patients with early-onset asthma) and 95 apparently healthy individuals. The study has been approved by the Bioethics Committee of Medical Institute of Sumy State University. Arg16Gly polymorphism in the β2-АR gene (rs1042713) was determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Statistical analysis of obtained results was performed using SPSS–17 program.
Results. There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the β2-AR gene depending on asthma severity with no regard for the age of onset (χ2 = 5.14; p = 0.27). With regard for the age of onset, we found out that early-onset BA was linked to a difference in genotype distribution for this polymorphic variant in patients with severe and non-severe course (χ2 = 14.76; р = 0.001). The frequency of Gly/Gly genotype was higher in patients with severe course (41.4%) as compared to patients with mild course (16.4%), while the frequency of Arg/Arg (32.9%) and Arg/Gly (50.7%) genotypes was higher in patients with mild asthma as compared to patients with severe course (24.3% and 34.3%). There was no significant difference in the distribution of genotypes in patients with late-onset asthma with regard to course severity (χ2 = 4.94; p = 0.084).
The relative risk of severe course for early-onset asthma was 3.84 times higher (95% CI 2.11–7.36; p = 0.001) in the recessive model, 2.58 times higher (95% CI 1.53–4,37, p = 0.001) in the dominant model, and 2.16 times (95% CI 1.56–3.04) higher in the additive model. In patients with late-onset asthma, no association was found in all models.
Conclusions. There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the β2-AR gene depending on asthma severity with no regard for the age of onset. When adjusted for the age of onset, the analysis revealed a difference in genotype distribution for this polymorphic variant in patients with severe and non-severe course having early-onset BA (р = 0.001). The frequency of Gly/Gly genotype was higher in patients with severe course as compared to patients with mild course. For patients with late-onset asthma, no differences were found (p = 0.084). Heterozygous and homozygous Gly allele carriers have a higher risk of early-onset asthma only.
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Ivanova, Elena. "AGROECOLOGICAL TESTING OF ALFALFA UNDER THE SAKHALIN CONDITIONS." Adaptive Fodder Production 2023, no. 1 (March 16, 2023): 21–29. http://dx.doi.org/10.33814/afp-2222-5366-2023-1-21-29.
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Field studies were conducted in 2021–2022 at the experimental site of the Sakhalin Research Institute of Agriculture on meadow-sod-gley medium loamy soil according to generally accepted methods. The technology of cultivation of alfalfa is in accordance with the methods of cultivation of perennial herbs developed by the Sakhalin Research Institute of Agriculture. The scheme of the experiment included ten varieties of alfalfa of various ecological and geographical origin. The greatest foliage was demonstrated by plants of the varieties Uralochka, Victoria, Nakhodka in the first mowing and the varieties Uralochka, Vela, Nakhodka, Sarga in the second. The varieties that entered the top three in terms of green mass yield for the period of the first mowing were Taisiya, Sarga and Uralochka varieties. As for the output of the dry mass it was similar. According to the amount of green and dry mass formed in the second mowing the varieties Nakhodka, Taisiya and Sarga were distinguished as the best. On average, for two mowing of the green mass the leading varieties were distributed in such order: the 1st place — the Taisiya variety, the 2nd place — Sarga and Nakhodka, the 3rd third place – Victoria, Agnia VIK and Uralochka. The average yield of the green mass of the Vela variety for two mowing was inferior to the standard Demetra variety by 8%, the yield of the Voronezhskaya 6 variety was at the standard level, the other varieties exceeded the standard by 7.4–21.2%. The average yield of the dry mass for two mowing of the Pavlovskaya 7 variety was slightly inferior to the standard variety, the Vela and Voronezh 6 varieties it was at the standard level, the rest exceeded it by 11.6–35.6%.
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Joux, Antoine, and Jacek Pomykała. "Preface for the Number-Theoretic Methods in Cryptology conferences." Journal of Mathematical Cryptology 14, no. 1 (October 13, 2020): 393–96. http://dx.doi.org/10.1515/jmc-2019-0111.
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AbstractNumber-Theoretic Methods in Cryptology (NutMiC) is a bi-annual series of conferences that waslaunched in 2017. Its goal is to spur collaborations between cryptographers and number-theorists and to encourage progress on the number-theoretic hard problems used in cryptology. The publishing model for the series is also mixing the traditions of the cryptography and number theory communities. Articles were accepted for presentation at the conference by a scientific commitee and werereviewed again at a slower pace for inclusion in the journal post-proceedings.In 2019, the conference took place at the Institut de Mathématiques de Jussieu, Sorbonne University,Paris. The event was organized in collaboration with the international association for cryptologic research (IACR) and supported by the European Union’s H2020 Program under grant agreement number ERC-669891. This support allowed us to have low registration costs and offer easy access to all interested researchers.We were glad to have the participation of five internationally recognized invited speakers who greatly contributed to the success of the conference.Nutmic 2019 Co-Chairs,Antoine Joux and Jacek Pomykała
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Sinkovič, Lovro, Vladimir Meglič, Špela Velikonja-Bolta, Marijan Nečemer, and Rajko Vidrih. "Nutrient Evaluation of Different Buckwheat Genetic Resources." АГРОЗНАЊЕ 17, no. 2 (February 3, 2017): 163. http://dx.doi.org/10.7251/agren1602163s.
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Common buckwheat (Fagopyrum esculentum Moench) and tartary buckwheat (Fagopyrum tataricum Gaerth.) are underutilized pseudo-cereals and both considered nutritional food. Eight common and eleven tartary buckwheat accessions acquired from Slovenian plant gene bank were grown at the experimental fields of the Agricultural Institute of Slovenia in 2014. Dried grains were homogenised and analysed for several nutrient parameters: moisture content (11–14% dry weight, DW), total proteins (11–16 % DW), dietary fibre (15–19 % DW), ash (2–6 % DW) and total fats (1.8–2.6 % DW). The fatty acids (C14:0, C16:0, C18:0, C18:1n9, C18:2n6, C18:3n3, C20:0) were determined using gas chromatography, free amino acids (Gly, Glu, Arg, Lys, Asp, Ser, Phe, Ala, Val, Thr, Pro, Ile, Met, His, Cys, Leu, Tyr) by the high-performance liquid chromatography and multi-mineral analysis (K, P, Si, S, Ca, Fe, Cl, Ti, Zn) using X-ray fluorescence spectroscopy. The results show significant differences between two buckwheat species, and their gene bank accessions for investigated nutritional parameters.
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Rennhack, A. M. O., D. M. W. Zee, E. S. Cunha, and M. F. Portilho. "Topics of Environmental Education Program in Coastal Areas." Water Science and Technology 25, no. 9 (May 1, 1992): 253–59. http://dx.doi.org/10.2166/wst.1992.0227.
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Researches and Studies made by the Department of Oceanography of the Institute of Geoscience of the State University of Rio de Janeiro UERJ, evidenced the need for educational support where environment-related questions were concerned. A wide range of environment problems tend to concentrate in coastal areas, owing to disordinate urban growth combined with the lack of substructure to cope with it A large number of these problems can be minimized through the participation of the local community. Thus the goals of environmental education are to supply information, to promote a change in the population's attitude toward environmental problems, besides stimulating its participation by fostering its sense of responsibility. Preliminary results have demonstrated that the community has shown great interest in the work that has been proposed, and it has contributed with participation, promising response. Environmental education is fundamental when we consider possible solutions for environmental problems in coastal urban centers. Only by educating the main cause of environmental problems, man himself, will it be possible to consider the question starting from its very origin. This abstract presents two pioneer experiments in the Municipio of Rio de Janeiro, which are “Muito Prazer Marapendi” (“Glad to know you, Marapendi”) and “Troca de Areias da Praia de Copacabana” (“Exchange of Sands in Copacabana Beach”).
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Капсамун, А. Д., Е. Н. Павлючик, and Н. Н. Иванова. "The productivity and nutritional value of the monoculture and grass mixtures with eastern goat’s rue on drained soil." Кормопроизводство, no. 7.2023 (October 25, 2023): 22–26. http://dx.doi.org/10.25685/krm.2023.7.2023.004.
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Исследования по изучению продуктивности, химического состава и питательной ценности травостоев козлятника восточного сорта Гале (Galega orientalis Lam.) в одновидовых посевах и в смеси со злаковыми травами тимофеевкой луговой ВИК 9 (Phleum pratense) и овсяницей луговой Сахаровская (Festuca pratensis) на выводных полях, рассчитанные на получение 6–8 тыс. корм. ед. с 1 га, проводились в 2019–2021 годах на опытном полигоне Губино ВНИИМЗ в Тверской области. Почва опытного участка осушаемая дерново-подзолистая. Междренное расстояние регулирующей сети — 18–40 м, глубина закладки дрен колебалась от 0,8 до 1,1 м. Учёт продуктивности козлятника восточного в год пользования (2021 год) показал, что наивысшую урожайность зелёной массы в среднем за два укоса обеспечили одновидовые посевы козлятника восточного без внесения минеральных удобрений на глубокооглееной почве — 29,07 т/га; на глеевой почве при внесении минеральных удобрений — 34,24 т/га; на глееватой дерново-подзолистой почве эти показатели возросли и составили 30,43 и 36,77 т/га соответственно. Ещё выше продуктивность козлятника получена на глеевой почве — 30,54 и 41,38 т/га соответственно. Энергетическая ценность 1 кг сухого вещества, полученного в 1-м укосе трав в период бутонизации – начала цветения, была высокой: в одновидовых посевах козлятника восточного она составила 0,96–1,03 корм. ед. и 10,3–10,8 МДж обменной энергии, в смешанных посевах — 0,95–1,03 корм. ед. и 9,05–9,84 МДж обменной энергии. Максимальная обеспеченность 1 корм. ед. переваримым протеином (243 г) была достигнута в одновидовых посевах козлятника восточного This investigation took place at the All-Russian Research Institute of Meliorated Lands in the Tver region in 2019–2021. The aim was to test the productivity, chemical composition and nutritional value of eastern goat’s rue, Gale (Galega orientalis Lam.) seeded as monoculture or mixed with such gramineous as common timothy, VIK 9 (Phleum pratense) and meadow fescue, Sakharovskaya (Festuca pratensis) on the emergency fields with the planned productivity of 6–8 thousand feed units from 1 ha. The soil of the trial field was drained sod-podzolic. The distance between the drains of the regulatory network — 18–40 m. The drain laying depth ranged from 0.8 to 1.1 m. In 2021 the monoculture provided the highest yield of green mass for 2 cuts on unfertilized gley soil — 29.07 t ha-1; under the application of mineral fertilizers — 34.24 t ha-1; on gley sod-podzolic soil — 30.43 and 36.77 t ha-1, respectively. Eastern goat’s rue had the highest productivity on gley soil — 30.54 and 41.38 t ha-1, respectively. The energy value of 1 kg of DM obtained in the first cut (budding – early flowering) was high: the monoculture provided 0.96–1.03 feed units and 10.3–10.8 MJ of exchange energy, the mixtures — 0.95–1.03 feed units and 9.05–9.84 MJ of exchange energy, respectively. The monoculture of eastern goat’s rue provided the highest yield of digestible protein — 243 g per 1 feed unit.
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Pliska, Vladimír, Antonín Pařízek, and Martin Flegel. "Neurohypophyseal Peptides from Prague and Swedish Laboratories Used as Medications: Desmopressin, Terlipressin, Carbetocin. Part 1: History of Research and Beginnings of Industrial Production." Chemické listy 116, no. 1 (January 15, 2022): 20–27. http://dx.doi.org/10.54779/chl20220020.
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From the fifties to the seventies of the last century, the neurohypophyseal peptides oxytocin and vasopressin constituted one of the main research areas at the Institute of Organic Chemistry and Biochemistry in Prague (IOCB). A significant contribution to this area is associated with the names of František Šorm, director of the said institute, and Josef Rudinger, head of the institute's peptide laboratory. At that time, newly developed research tools enabled to synthesize structural analogues of these hormones in numerous laboratories worldwide and hence to investigate the structure-activity relationships within this peptide group. Contributions of single peptide-chain positions to the respective biological activities were identified which opened a possibility to rationalize a design of peptides with a combination of changes in several positions. Several clinically interesting peptides were synthesized in the late 1960s at the IOCB and employed as therapeutics: [(Gly)3-Cys1,Lys8]-vasopressin (Glypressin Ferring®, Terlipressin INN), 1-deamino-8-ᴅ-arginine vasopressin (Desmopressin INN, dDAVP), and later the uterotonics carbetocin (INN), widely used in obstetrics to prevent postpartum haemorrhage. Since the industrial production of peptide therapeutics was scarcely possible under the conditions of socialist economy in Czechoslovakia as well as in other countries under the Soviet influence, F. Šorm agreed to use the already established scientific contacts of IOCB with the Swedish pharmaceutical company Ferring AB and to transfer the production licences to Sweden. The license agreements were signed in 1969 and led to a quick spread of dDAVP in the substitution therapy of the central form of diabetes insipidus and, moreover, contributed to a fast upsurge of the Ferring company. Somewhat later, Glypressin was produced as a therapeutic with a prolonged action in cases of cardiovascular collapse. Contacts between Prague peptide chemists and the Ferring company lasted on a rather informal base until the end of the 1980s. After the fall of the totalitarian regime in Czechoslovakia in 1990, Ferring started a joint-venture collaboration with the newly organized Czech company Léčiva st.p. Praha in a newly established group Prague Polypeptide Institute spol. s. r.o. (later Ferring-Léčiva A.S.). A substantial part of the peptide-production capacities was then transferred to new buildings in Prague.
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Paliichuk, E., and Yu Lukina. "Stylistic devices for creating humorous effect: an empirical research (based on Ted Talks case study)." Studia Philologica 1, no. 14 (2020): 60–67. http://dx.doi.org/10.28925/2311-2425.2020.149.
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The stylistic analysis is a preliminary stage to define the pragmatic potential of the TED Talks texts. The most recurrent literary devices used in the talks are pun, irony, oxymoron, epithet, metaphor, parallel constructions, periphrasis, zeugma, chiasmus, etc. It is assumed that the TED Talks texts are saturated with stylistically coloured verbal means, which ensure the self-sustainability of such texts in terms of their influence of the audience. To verify the hypothesis, an experiment has been conducted, with 40 participants aged 21-37, all students are from the Institute of Philology of Borys Grinchenko Kyiv University. The two groups of participants (text (transcript) / video) answered the same questions aimed at evaluating the TED Talks in terms of being witty, ironic, sarcastic, humorous, as well as in terms of the change in the emotional state of the readers and viewers, and in terms of the emotions (feeling bored, upset, cheerful, laughing, glad, inspired, enthusiastic) the respondents felt after they were shown a video or proposed to read a transcript. The findings demonstrate the degree of differences in responses between the groups (text / video), which speaks for sustainability of textual level of presentation in evoking certain emotions due to specific combination of verbal means and thus support the hypothesis as to high degree of pragmatic potential of TED Talks texts in creating humor effects.
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S.V. KRISHNA REDDY, C.C.S. RAO, and S. KASTURI KRISHNA. "Enhancement of productivity, water- and nutrient use efficiency and economics through drip fertigation and tray seedlings in FCV tobacco (Nicotiana tabacum) under irrigated Alfisols of Andhra Pradesh." Indian Journal of Agronomy 67, no. 3 (November 15, 2022): 294–303. http://dx.doi.org/10.59797/ija.v67i3.32.
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A field experiment was conducted for two consecutive seasons (2014–16) and a bulk trial for one year (2016– 17) at ICAR-Central Tobacco Research Institute Research station, Jeelugumilli, West Godavari district, Andhra Pradesh under semi arid tropical climate to study the effect of different combinations of drip irrigation, furrow irrigation, tray seedlings, normal seedlings, drip ferti-gation and soil application of fertilizers at 3rd, 25–30, 40–45 days after planting or 10, 25–30, 40–45 days after planting, on green leaf yield (GLY), cured lead yield (CLY), grade index (GI), leaf nicotine and reducing sugars, water- and fertilizer use efficiency as well as economics in FCV tobacco (Nicotiana tabacum). The experiment was laid out in a RBD with five replications, nine treatment combinations and was conducted with specified treatments for the first two years and bulk plots during the following year. Two separate plots, viz. N0 P26.2K99.6 (T10) and N120P26.2K0 (T11) were grown for comparison and calculation of N and K use efficiencies during the first two years. T4 (drip irrigation, tray seedlings, drip fertigation at 3rd, 20–25 and 40–45 DAP) and T2 (drip irrigation, tray seedlings, drip ferti-gation at 10, 25–30 and 40–45 DAP) recorded increased GLY by 23.87, 16.95, CLY by 16.67, 13.83 and GI by 23.43, 21.46% during first and second years, respectively and also higher leaf nicotine when compared to furrow irrigation, normal seedlings, soil application of fertilizers (T9 ) i.e. farmers practice. N, P, K uptake and nitrogen and potassium use efficiencies under different treatments were evaluated. Bulk plots grown with tray seedlings, drip irrigation and drip fertigation accrued additional profit of `25,285, benefit: cost ratio of 1.82, WUE of 11.74 kg of cured leaf/ ha-mm of water as compared to 5.77 kg of cured leaf/ha-mm in normal seedlings, furrow irrigation and soil application of fertilizers. Only 57.2% of total quantity of furrow irrigation is required for drip irrigation and there is 203.5% increase in WUE with drip irrigation as compared to furrow irrigation.
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Goyal, Mukul, K. C. Lakshmaiah, K. Govind Babu, Amit Rauthan, Linu Abraham Jacob, Singh Tejinder, L. K. Rajeev, G. Mehar Kumar, and Vineetha Unnikrishnan. "Imatinib Resistance Mutation Analysis Pattern In Chronic Myeloid Leukemia (CML) Patients on Imatinib In Indian Population." Blood 116, no. 21 (November 19, 2010): 4491. http://dx.doi.org/10.1182/blood.v116.21.4491.4491.
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Abstract Abstract 4491 Background- Imatinib has revolutionized the treatment of CML. Still there are hurdles with the drug, as, with the passage of time patients are either not responding or showing loss of response. The nonresponsiveness has been proved to be due to genetic mutations which may be primary or acquired. Still less is known about the pattern of mutations especially in asian countries. So there is a need to identify the pattern of mutations, so that second line tyrosine kinase inhibitors’ response may be studied with respect to these mutations and new drugs can be designed concentrating on the most common mutations. In an attempt to identify a pattern of mutation in asian population we carried out an analysis at our centre. Methods- The patients who were on imatinib at Kidwai memorial institute of oncology, underwent testing for hematological response(HR) every month, cytogenetic response (CyR) every 6 month and molecular response(MR) every year. Patients who did not achieve either hematologic or cytogenetic or molecular milestones or had loss of response underwent imatinib resistance mutation analysis(IRMA). We analyzed a total of 102 patients. The IRMA was done at Oncquest Laboratories Ltd.,New Delhi, India. The method used at the laboratory is a combination of RTPCR and double pass sequencing. The sequence results were analyzed using BLAST software from NCBI and GRAPH ANALYSIS software from applied biosystems. Results- Between Jan. 2007 to May 2010, a total of 102 patients were analysed for imatinib resistance. Out of these 102 patients, 5(4.9 %) patients presented in blast crisis, 7(6.86%) in accelerated phase and 90(88.23%) in chronic phase. Male to female ratio was 1.7:1. 95 patients had achieved complete hematological response(CHR) at the end of 3 mths but 7 patients did not achieve CHR at 3 mths. So these were the candidates of IRMA. 2 patient had loss of HR. 42 patients did not achieve cytogenetic milestones. 28 patients had loss of cytogenetic response. 15 patients did not achieve major molecular response. and 8 had loss of molecular response. So these 102 patients were candidates for IRMA. Analysis revealed: No mutation - 74 patients. F 359 I – 3 patients, T 315 I(Thr to Ile) – 4 patients, M 351 T (Met to Thr) – 5 patients, M 244 V (Met to Val) – 2patients, H 395 R – 1 patients, Y 253 H – 2 patients, 355 G(GLU to GLY) – 1 patient, 250 E (GLY to GLU)- 1 patient, G250 E (GLY to GLY) - 1patient, F 359 C (Phe to Cys) – 1 patient, F 311 L(Phe to Leu) – 1 patient, Y 253 F(Tyr to Phe) – 1 patient, E 275 K (Glu to Lys) – 2 patients, V 253 F – 2 patients and F317L- 1 patient. Conclusions- Most of the patients (74/102 patients) did not show any mutations. Most common mutation seen was M 351 T in 5 patients. T 315 I mutation was seen in 4 patients and all these patients had a loss of response. All these mutations should be studied with respect to response to second line tyrosine kinase inhibitors particularly in asian Indian population. Disclosures: No relevant conflicts of interest to declare.
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Lützen, Karin Cohr. "Dag Hundstad, Tone Hellesund, Runar Jordåen og Marthe Glad Munch-Møller (red.): Skeiv lokalhistorie. Kulturhistoriske perspektiver på sammekjønnsrelasjoner og kjønnsoverskridelser.DagHundstadToneHellesundRunarJordåenMarthe Glad Munch-Møller(red.)Skeiv lokalhistorie. Kulturhistoriske perspektiver på sammekjønnsrelasjoner og kjønnsoverskridelser.Skrifter fra Norsk lokalhistorisk institutt ved Nasjonalbiblioteket nr. 48. Oslo 2022. 512 sider." Historisk tidsskrift 102, no. 2 (June 9, 2023): 173–76. http://dx.doi.org/10.18261/ht.102.2.10.
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Varisli, O., C. Uguz, C. Agca, J. Green, and Y. Agca. "97 COMPARISON OF MOTILITY AND ACROSOMAL INTEGRITY OF ELECTRO-EJACULATED AND EPIDIDYMAL RAM SPERM AFTER EXPOSURE TO VARIOUS ANISOSMOTIC SOLUTIONS, CRYOPROTECTIVE AGENTS, AND TEMPERATURES." Reproduction, Fertility and Development 20, no. 1 (2008): 129. http://dx.doi.org/10.1071/rdv20n1ab97.
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Effective ram sperm cryopreservation protocols, which would yield acceptable lambing rates following AI, are currently lacking. The objectives of the current studies were to compare the effects of various anisosmotic conditions, cryoprotective agents (CPA), and temperatures on the motility and acrosomal integrity of electro-ejaculated and epididymal ram sperm. Three experiments were conducted. In Experiment 1, electro-ejaculated and epididymal ram sperm were exposed to 75, 150, 225, 600, 900, and 1200 mOsm kg–1 sucrose solutions, held for 5 min, and then returned to isosmotic conditions. Motility characteristics of sperm during exposure to each anisosmotic solution and after return to isosmotic conditions were determined. In Experiment 2, electro-ejaculated and epididymal ram sperm were exposed to 1 m glycerol (Gly), dimethyl sulfoxide (DMSO), ethylene glycol (EG), or propylene glycol (PG) for 5 min and then returned to isosmotic conditions. Motility characteristics of sperm samples during exposure to each CPA solution and after return to isosmotic conditions were determined. In Experiment 3, effects of various temperatures on motility characteristics of electro-ejaculated and epididymal ram sperm were determined after exposure to three different sub-physiologic temperatures (4, 10, and 22�C) for 30 min and subsequently return to 37�C. A computer-assisted semen analysis system was used to determine sperm motility characteristics. Epifluorescence microscopy was used to determine sperm acrosomal integrity after fixing and staining with Alexa Fluor-488-PNA (Molecular Probes, Eugene, OR, USA). The data were analyzed by ANOVA by using SAS (SAS Institute, Inc., Cary, NC, USA). The motility of electro-ejaculated ram sperm was significantly more affected by anisosmotic stress than was that of epididymal ram sperm (P < 0.05). While anisosmotic stress had no effect on acrosomal integrity of epididymal ram sperm, there was a significant reduction in acrosomal integrity for electro-ejaculated ram sperm after the addition and removal of a 75 mOsm sucrose solution. The abrupt addition and removal of 1 m Gly, DMSO, EG, or PG had no effect on the motility and acrosomal integrity of epididymal ram sperm (P > 0.05). However, there was a slight decrease in acrosomal integrity for electro-ejaculated ram sperm after exposure to 1 m Gly, DMSO, or EG (P > 0.05). Both epididymal and electro-ejaculated ram sperm exhibited temperature-dependent loss of motility and acrosomal integrity (P < 0.05). However, electro-ejaculated ram sperm were more sensitive to chilling stress than were epididymal sperm (P < 0.05). In conclusion, current data overall suggest that while epididymal ram sperm are extremely resilient to various cryobiologically relevant stress conditions, ejaculated ram sperm demonstrate greater sensitivity to such stressors. These current findings should be taken into account when handling and developing cryopreservation protocols for ejaculated and epididymal ram sperm.
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Оберган, Т. Ю., М. Е. Григорьева, Л. А. Ляпина, Т. А. Шубина, Н. Ф. Мясоедов, and Л. А. Андреева. "The effect of glyproline peptides on levels of nitric oxide metabolites and tissue plasminogen activator activity in healthy rats and rats with metabolic syndrome." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 4() (December 18, 2020): 88–94. http://dx.doi.org/10.25557/0031-2991.2020.04.88-94.
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Введение. Короткие регуляторные пролинсодержащие пептиды могут оказывать противосвертывающие эффекты в организме и проявлять защитное действие при тромбозах. Цель исследования - выявление косвенных эффектов пептидов глипролинового ряда Pro-Gly-Pro (PGP) и Arg-Glu-Arg-Pro-Gly-Pro (RERPGP) на функцию эндотелия сосудов и состояние системы фибринолиза в норме и при нарушении липидного обмена. Методика. Пептиды были синтезированы в институте молекулярной генетики РАН. В экспериментах использовано 60 лабораторных белых крыс-самцов линии Wistar. Проведено 2 серии экспериментов - на здоровых крысах и животных с экспериментально воспроизведенным метаболическим синдромом (МС). Пептиды вводили интраназально в течение 7 сут через каждые 24 ч (100 мкг/кг) ежедневно. Анализ крови осуществляли через 20 и 168 ч после завершающего введения пептидов. Определяли уровни метаболитов оксида азота (NO) и активности тканевого активатора плазминогена (ТАП). Результаты. Выявлены различия в действии PGP и RERPGP на исследуемые параметры у здоровых животных. В плазме крови крыс через 20 ч после семикратного введения пептида PGP установлено значительное повышение активности ТАП и метаболитов NO, которое сохранялось на протяжении 168 ч эксперимента, в то время как под влиянием RERPGP отмечалось повышение только уровня нитратов и нитритов через 168 ч после его применения. Пептид PGP также оказывал выраженные эффекты на функцию эндотелия организма и при развитии МС. Активность ТАП значительно и статистически значимо увеличивалась через 20 ч после семикратного введения пептида, эти изменения наблюдались также спустя 168 ч после применения PGP. Эти величины практически соответствовали значениям ТАП у здоровых крыс. Уровень метаболитов NО также значимо повышался при воздействии PGP на фоне МС. Сделано предположение о возможных механизмах действия пептидов на сосудистый эндотелий. Заключение. Пептиды глипролинового ряда оказывали стимулирующее влияние на функцию эндотелия в организме как в норме, так и при патологии, повышая активность тканевого активатора плазминогена и концентрацию метаболитов оксида азота. Short regulatory proline-containing peptides can exert an anticoagulation effect and be protective in thrombosis. The aim of this study was to identify indirect effects of glyproline peptides Pro-Gly-Pro (PGP) и Arg-Glu-Arg-Pro-Gly-Pro (RERPGP) on vascular endothelial function and the fibrinolytic system in normal and impaired lipid metabolism. Methods. Peptides were synthesized at the Institute of Molecular Genetics, Russian Academy of Sciences. Experiments were performed on 60 male Wistar rats divided into healthy animals and animals with experimental metabolic syndrome (MS). Peptides (100 μg/kg) were administered intranasally, once a day for 7 days. Blood tests were performed 20 h and 168 h after the last administration of the peptides. Concentrations of nitric oxide (NO) metabolites (sum plasma concentration of nitrate and nitrite) and the activity of tissue plasminogen activator (TAP) were measured. Results. The effects of PGP and RERPGP on the endothelial function in healthy animals were different. Significant increases in both TAP activity and NO metabolite concentration were found in plasma 20 h after 7 PGP administrations, which persisted throughout 168 h of the experiment. Only an increase in nitrate/nitrite was observed at 168 h after the RERPGP administration. PGP also exerted pronounced effects on the endothelial function, including in MS. TAP activity was significantly increased at 20 h after 7 administrations of the peptide, and this effect remained at 168 h after the PGP administration. These values were practically similar to the TAP values in healthy rats. Concentrations of NO metabolites were also significantly increased after the PGP exposure of MS rats. Possible mechanisms for the peptide activation of vascular endothelium are discussed. Conclusion. Glyproline peptides had a stimulatory effect on the endothelial function both in normal and pathological conditions by increasing the TAP activity and the concentration of NO metabolites.
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Janaway, Christopher. "Schopenhauer's Pessimism." Royal Institute of Philosophy Supplement 44 (March 1999): 47–63. http://dx.doi.org/10.1017/s1358246100006664.
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This series of lectures was originally scheduled to include a talk on Schopenhauer by Patrick Gardiner. Sadly, Patrick died during the summer, and I was asked to stand in. Patrick must, I am sure, have been glad to see this series of talks on German Philosophy being put on by the Royal Institute, and he, probably more than anyone on the list, deserves to have been a part of it. Patrick Gardiner taught and wrote with unfailing integrity and quiet refinement in the Oxford of the 1950s, '60s, '70s and '80s, when the changing fashions in philosophy, and Oxford philosophy in particular, were quite remote from his own central interests. He went his own way, radically but quite undemonstratively. His book on Schopenhauer, originally published in 1963, was a beacon in the night as far as English-language publications on that philosopher are concerned. It is still a leader in the field, and I am pleased to say it has been re-issued just this year after being out of print for too long. Patrick worked in aesthetics, on Kant, and on the German Idealists, showing an expertise and a fondness for Fichte which now seem well ahead of their time. He also contributed well known books on Kierkegaard and on the philosophy of history. I am honoured to be invited as Patrick's replacement. He was a true pioneer, whom all of us working in these several fields that have now grown more fashionable and more populated should pause to salute.
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Günther-Diringer, Detlef. "AR-applications with historical maps." Abstracts of the ICA 2 (October 9, 2020): 1–2. http://dx.doi.org/10.5194/ica-abs-2-34-2020.
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Abstract. In cooperation with the Badische Generallandesarchiv (GLA) Karlsruhe, the officially archive of the former state Baden, various projects in the field of virtual and augmented reality (VR/AR) have been carried out.The VR project “Danube - Floating Spaces” refers to an exhibition by the GLA Karlsruhe in cooperation with the Institute for Danube Swabian History and Regional Studies, Tübingen. The entire exhibition was constructed in the third dimension and can now be experienced using different devices (offline PC version, WebGL version for Internet access or VR version for the HTC-Vive (VR glasses). An important functionality is the detailed enlargement option of the historical maps, so that many details in the maps can now be seen better than in the original exhibition (Keller 2019). WebGL-version: https://www.hs-karlsruhe.de/gim/angebote-fuer-schueler-und-interessierte/virtuelle-ausstellung.One of the highlights of the map inventory of the GLA is certainly the Great Palatinate Rhine Map from 1590. This hand-drawn unique measures approx. 0.45m × 12m and is to be presented in an exhibition in 2021 or 2022. Based on the high-quality digital copy available from the GLA, various student projects and theses are currently being carried out to augment digitally this fascinating map. Due to their geometrical-graphic structures, analogue cartographic representations are generally very suitable for performing AR applications. Based on the geographical uniqueness, sections of the maps can be defined as necessary image AR targets, so that the software of a game engine, such as e.g. Unity with the Vuforia extension recognizes that a digital element has to be placed at a specified place. This can be made visible using a tablet or smartphone with a camera. The aim is for visitors of the exhibition to receive additional geographical information with prepared tablets that are held over the map: Figure 1: 3D-visualization of the historical development of the fortress Philippsburg (Udenheim in 1590, left: part of the original map, right: with overlayed AR-element). In addition to the 3D-visualization of 1590 (see figure on the right), the fortifications of the 30 Years War and subsequent extensions are also visible (1635/1690/1735). At that time, Philippsburg was one of the largest fortresses in all of Germany, but it was destroyed by Napoleon around 1800. The final timeline from 1856 is an excerpt from the “Carte from the course of the Rhine” with the straightening of the Rhine through Tulla and shows the significant changes in the landscape that moved the main stream of the Rhine away from Philippsburg (Färber 2019).Animated visualizations of pictorial representations:In addition to the historical landscapes, the map from 1590 also contains many small pictorial drawings that show human activities during this time, from ferries, fishermen, gold washers to hunters and wine merchants. These drawings were visualized in 3D, animated and, with the help of Unity, placed in the appropriate place. It is intended as a search game for children who can use a tablet and this app to search for more than 20 different scenes on the map and thus experience this historical map in a playful way (Boric 2019): Figure 2: 3D-visualization of a ship on the river Rhine (left: original map, right: 3D-AR-element).The last project currently planned is the tablet-supported visualization of the landscape changes from the Upper Rhine regulation by Tulla (beginning in the 1820s) until today. On the basis of various historical and current geodata (Rhine river maps 1838/1872, current aerial photos and OpenStreetMap data), the 400-year cultural history of the Upper Rhine between Rastatt and Speyer can be imagined. The georeferencing of the historical map is very challenging. While the maps of the Rhine river from the 19th century are precise in terms of surveying technology, the Great Electoral Palatinate Rhine river map is more of a landscape picture and is far from an exact map representation. Here, the locations of the historical settlements are the only point of reference for a link with the available exact georeferenced geodata. This application will be presented at the exhibition in the GLA in 2021/22.
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Shea, M. Kyla, Stephanie Harshman, Sarah Booth, Donald Smith, Cathy Carlson, Lindsey Harper, Leonor Cancela, Marcio Simão, and Richard Loeser. "The Effect of Low Dietary Vitamin K Intake on the Development of Osteoarthritis in Aging Mice." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 698. http://dx.doi.org/10.1093/cdn/nzaa050_021.
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Abstract Objectives Epidemiological evidence suggests that low vitamin K status is associated with osteoarthritis (OA) development and progression. However, it is not clear if low vitamin K intake is causally linked to OA. To address this gap, we manipulated vitamin K intake in aging mice to test its effect on OA development. Methods Eleven-month old male C57BL/6J mice were randomly assigned to a low phylloquinone diet containing 120 mcg phylloquinone/kg diet (n = 32) or a control diet containing 1.5 mg phylloquinone/kg diet (n = 30) for 6 months. Knee OA was evaluated histologically using Safranin O and H&E staining. Adjacent sections were immunostained using antibodies directed against matrix gla protein (MGP) and gla rich protein (GRP), two vitamin K-dependent proteins present in cartilage that are implicated in OA. Post-mortem phylloquinone concentrations in liver, kidney, intestine, and brain were measured using HPLC. Results While body weight gain was comparable between the two groups (repeated measures ANOVA, group P = 0.63, group*time P = 0.77, time P < 0.01), mortality was increased in the low phylloquinone diet group compared to the control group (eleven versus three mice) within the first 100 days of the experiment (log-rank test P = 0.02). The phylloquinone tissue concentrations were lower in the mice fed the low vitamin K diet compared to those fed the control diet (Wilcoxon test, all P < 0.01). Mice fed the low phylloquinone diet had higher Safranin-O scores (indicative of articular cartilage proteoglycan loss) compared to mice fed the control diet [median (interquartile range) = 20 (11) and 14 (14), respectively; Wilcoxon two sample test P = 0.01]. The articular cartilage structure scores did not differ between the two groups [median (interquartile range) = 11 (11) and 9 (9), respectively; Wilcoxon test P = 0.19]. While MGP and GRP were expressed in articular and meniscal cartilage, expression did not differ significantly between the two groups (Wilcoxon P ≥ 0.24). Conclusions Our findings suggest low vitamin K status can promote articular cartilage proteoglycan loss in older male mice. Future studies are needed to confirm our findings and obtain a better understanding of the molecular mechanisms underlying vitamin K's role in OA. Funding Sources The National Institute of Arthritis, Musculoskeletal and Skin Disease and the US Department of Agriculture.
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Bittencourt, R. F., E. Oba, A. de L. Ribeiro Filho, M. F. Vasconcelos, C. E. A. Biscarde, D. C. Almeida, and V. F. Silveira. "86 VIABILITY AND FERTILITY OF RAM SEMEN CRYOPRESERVED WITH DIMETHYL ACETAMIDE AND TREHALOSE." Reproduction, Fertility and Development 22, no. 1 (2010): 201. http://dx.doi.org/10.1071/rdv22n1ab86.
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Eleven semen samples from Santa Ines breed rams were cryopreserved with the objective of studying the effect of the dimethyl acetamide (DMA, 3%) or glycerol (GL, 6%) in an extender (Tris) with or without trehalose (TRE, 100 mOsmol) on post-thaw sperm viability and fertility. After the evaluation, the semen was diluted in extenders (TRIS+GL6%; TRIS+GL6%+TRE; TRIS+DMA3%; Tris+DMA3%+TRE) and then frozen. The post-thaw kinetic sperm parameters evaluated were the percentage of total motility (TM) and rapid spermatozoa (RAP), track speed (VCL), lateral amplitude of head (ALH), and linearity (LIN). The sperm viability was verified using the fluorescence markers propidium iodide (PMI, plasmatic membrane integrity), JC-1 (MMP, mitochondrial membrane potential), and FITC-PSA (ACI, acrosomal integrity). The spectrum of DNA sperm damage was assessed by single cell gel electrophoresis (Comet assay), and the measurements performed were tail moment (TMOM) and tail intensity (TINT; Comet Assay II software, Perceptive Instruments, Haverhill, UK). The sheep estrus synchronization protocol (n = 170) was 12 days of sponge with 60 mg of medroxyprogesterone acetate and 300 UI of eCG i.m. at sponge withdrawal. The ewes were inseminated on 57.5 h after sponge removal with 150 × 106 of live spermatozoa. The conception rates (CR) were verified for ultrasonography 45 days after insemination. The statistical analysis was performed using SAS software (SAS Institute Inc., Cary, NC, USA). The means (±SEM) of in vitro post-thaw sperm parameters and fertility rates are shown in Table 1. The greatest (P < 0.05) rates of TM and RAP for the GLY groups were observed in relation to the DMA ones. It was also verified the inferiority (P < 0.05) in the VCL and ALH for the trehalose extenders in both groups with GLY and DMA. The values (%) of TINT and TMOM were 14.9 and 03.9, 15.8 and 03.8, 14.7 and 02.9, and 16.6 and 04.4, respectively, for TRIS+GL6%, TRIS+GL6%+TRE, TRIS+DMA3%, and TRIS+DMA3%+TRE (P > 0.05). The integrity rates of all sperm membranes were superior for TRIS+GL6% in relation to TRIS+DMA3%. In conclusion, the DMA had apoor cryoprotective effect for ram semen. The addition of trehalose promoted negative effect on sperm kinetics, although it improved levels of PMM post-thawing in the DMA extender. The conception rate did not present a difference (P > 0.05) among the groups. Table 1.
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Ghifari, Muhammad, Anni Kholilah, and Miftahun Naufa. "PENGENALAN LUKIS KACA SEBAGAI MEDIA HIAS DAN CENDERA MATA PADA SISWA-SISWI SMA N 1 KOTA JANTHO." Gorga : Jurnal Seni Rupa 10, no. 1 (May 1, 2021): 73. http://dx.doi.org/10.24114/gr.v10i1.21107.
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Everyone who likes beauty is beauty that is naturally created or that is created from human work. However, not everyone knows how to create beauty from the objects around them. How to turn a simple object into something that is more attractive, more beautiful and even has a sale value. The activity of introducing Glass Painting as a decorative medium and souvenirs will certainly hone the creativity of SMA N 1 Jantho City students. The introduction of glass painting trains students to be creative in processing the natural resources around them. From objects made of glass that are not used, they are given a touch of art and polished in such a way that they become works and art products that can later become souvenirs. It does not stop with the introduction and manufacture of glas painting, students are given directions and an understanding of how to make these works of art can have economic value. The products produced in this activity are expected to be marketed as a typical souvenir of the City of Jantho.Keywords: painting, glass, decorative media, souvenirs. AbstrakSetiap orang menyukai keindahan baik itu keindahan yang tercipta secara alami maupun yang diciptakan dari hasil karya manusia. Namun tidak setiap orang tahu bagaimana cara menciptakan keindahan dari benda-benda yang ada disekitarnya. Bagaiman cara menyulap sebuah benda sederhana menjadi sesuatu yang lebih menarik, lebih indah bahkan memiliki nilai jual. Kegiatan pengenalan Lukis Kaca sebagai media hias dan cendera mata tentu akan dapat mengasah kreatifitas siswa-siswi SMA N 1 Kota Jantho. Pengenalan seni lukis kaca melatih siswa-siswi untuk dapat kreatif mengolah sumber daya alam yang ada disekitar mereka. Dari benda-benda berbahan kaca yang sudah tidak terpakai diberi sentuhan seni dan dipoles sedemikian rupa sehingga menjadi sebuah karya dan produk seni yang nantinya dapat menjadi cendera mata. Tidak berhenti sampai pengenalan dan pembuatan lukis kaca, siswa siswi diberikan arahan dan pemahaman bagaimana caranya menjadikan karya seni tersebut dapat memiliki nilai ekonomis. Produk yang dihasilkan pada kegiatan ini diharapkan dapat dipasarkan sebagai cendera mata khas Kota Jantho Kata Kunci: lukis, kaca, media, cendera mata. Authors: Muhammad Ghifari : Institut Seni Budaya Indonesia AcehAnni Kholilah : Institut Seni Budaya Indonesia AcehMiftahun Naufa : Institut Seni Budaya Indonesia AcehReferenes: Azis, A. C. K. (2017). Pemanfaatan Sampah Plastik Menjadi Karya Seni Rupa di Kecamatan Deli Tua. BAHAS, 28(3). 268-272. https://doi.org/10.24114/bhs.v28i3.10077.Ghifari, Muhammad. (2020). “Kegiatan Pengabdian Seni Rupa”. Hasil Dokumentasi Pribadi: 2020, SMA N 1 Kota Jantho.Marchanda, Fajar. (2020). “Kegiatan Pengabdian Materi Seni Rupa”. Hasil Dokumentasi Pribadi: 2020, SMA N 1 Kota Jantho.Naufa, Miftahun. (2020). “Kegiatan Pengabdian Seni Rupa”. Hasil Dokumentasi Pribadi: 2020, SMA N 1 Kota Jantho.Putra, P. D., Lisyanto, L., Azis, A. C. K., & Zainal, A. (2019). Rekayasa Bahan Makanan dari Singkong Dalam Mensejahterakan Perekonomian Masyarakat di Kabupaten Labuhan Batu Utara. Jurnal Pengabdian Kepada Masyarakat, 25(3), 172-175. https://doi.org/10.24114/jpkm.v25i3.15396.Susanto, Mikke. (2002). Diksi Rupa Kumpulan Istilah Seni Rupa. Yogyakarta: Kanisius.
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Rees, Gareth. "Introduction: The 11th International Circumpolar Remote Sensing Symposium." Polar Record 48, no. 1 (November 29, 2011): 1. http://dx.doi.org/10.1017/s0032247411000659.
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The 11th International Circumpolar Remote Sensing Symposium (ICRSS) was held at the Scott Polar Research Institute in Cambridge from 20 to 24 September 2010. The ICRSS series began in Yellowknife in 1990 and has been held biennially since then. The 2010 meeting was the sixth time it had been held in Europe and the second time in the UK, but the first time in Cambridge. 35 people attended the meeting, from 11 countries, and over 20 oral presentations were made in addition to a well-attended poster session. The majority of the oral presentations have been developed into papers and appear in this issue of Polar Record, having been subjected to the normal peer review and editorial process, and they give a fair idea of the range of topics covered at this lively meeting. Sessions at the symposium were organised around the themes of cross-platform observations, ice and snow, topography, vegetation and observations of animals. The last theme produced three fascinating presentations on the monitoring of penguins, seals and fish from spaceborne and airborne platforms. The papers in this issue address two broad areas: terrestrial ice and snow, and high-latitude vegetation (sea ice, and polar zoology, were also represented at the meeting). All of them deal to a greater or lesser extent with technological innovation in assessing, mapping and monitoring these aspects of the polar regions, and several of them focus strongly on the development of new methods, or the assessment of newly available datasets. This issue of Polar Record thus provides a limited snapshot of the ‘state of the art’ in remote sensing of polar regions. It is the result of sustained effort by the authors of the papers, and the team of anonymous reviewers. I am glad here to record my gratitude to all of them, and to the helpers at the symposium, particularly Katya Shipigina, Allen Pope and Claire Lampitt.
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Panova, Gayane G., Konstantin N. Semenov, Anna S. Zhuravleva, Yuriy V. Khomyakov, Elena N. Volkova, Galina V. Mirskaya, Anna M. Artemyeva, Nailia R. Iamalova, Victoriya I. Dubovitskaya, and Olga R. Udalova. "Obtaining Vegetable Production Enriched with Minor Micronutrients Using Fullerene Derivatives." Horticulturae 9, no. 7 (July 20, 2023): 828. http://dx.doi.org/10.3390/horticulturae9070828.
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Elaborating on the methods and means of enriching nutrition, including that of plants, with a number of microelements that are vital for humans is now very important due to the unresolved acute problems of micronutrient deficiency and imbalance, which affect the majority of the population of various countries in the world. Promising solutions for the implementation of biofortification in terms of safety, efficiency, size, biocompatibility, and transportability are the water-soluble derivatives of C60 or C70 fullerene. By now, the use of water-soluble fullerenes (C60(OH)22–24 or C70(OH)12–14 fullerenols, C60 fullerene with glycine or with arginine: C60-L-Gly or C60-L-Arg) with various functional groups for plant enrichment is pioneering. Experimental research work was carried out at the agrobiopolygon of the Agrophysical Research Institute under controlled microclimate conditions. This work constituted an assessment of the influence of C60(OH)22–24 fullerenol introduction into the soil on the content of macro- and microelements in the soil and in plants, for example, cucumber, as well as on the plants’ physiological state (photosynthetic pigments, the intensity of lipid peroxidation, the activity of peroxidase and catalase enzymes), growth, and element content. Its aim was to study the possibility of enriching the plants’ production (Chinese cabbage, tomato, and cucumber) with compositions of the fullerene derivatives (C60-L-Gly or C60-L-Arg, C60(OH)22–24 or C70(OH)12–14 fullerenols) and selenium or zinc compounds by introducing them into a nutrient solution or by foliar treatment of plants. It was revealed that the introduction of solutions of C60 fullerenol in various concentrations (1 mg/kg, 10 mg/kg, and 100 mg/kg) into soddy-podzolic sandy loamy soil contributed to the activation of the processes of nitrogen transformation in the soil, in particular, the enhancement of the process of nitrification, and to the increase in the content of mobile forms of some macro- and microelements in the soil as well as of the latter in plant organs, for example, in cucumber plants, especially in their leaves. Along with this, the plants showed an increase in the content of photosynthetic pigments, a predominant decrease in the activity of the oxidative enzyme peroxidase and in the intensity of lipid peroxidation, and an increase in the content of the reducing enzyme catalase. The improvement in the physiological state of plants had a positive effect on the growth rates of cucumber plants. The compositions of solutions of amino acid fullerenes (C60-L-Gly or C60-L-Arg) and sodium selenate as well as C60 or C70 fullerenols and zinc sulfate, selected on the basis of different charges of molecules or functional groups of fullerene derivatives, showed higher efficiency at low concentrations in enriching the plant products of Chinese cabbage, tomato, and cucumber with selenium and zinc, respectively, compared with mineral salts of the indicated elements and control (edible part of Chinese cabbage: by 31.0−89.0% relative to that in the control and by 26.0–81.0% relative to the treatment of plants with a sodium selenate; tomato fruits: by 33.7–42.2% relative to that in the control and by 10.2–17.2% relative to the treatment of plants with a sodium selenate; cucumber fruits: by 42.0–59.0% relative to that in the control and by 10.0–23.0% relative to the treatment of plants with a zinc sulfate). At the same time, the quantitative characteristics of growth, productivity, and/or quality of the obtained products increase and improve accordingly. The prospects for further research include an in-depth study into the mechanisms of the compositions of fullerene derivatives and various compounds of trace elements’ influence on the plants, as well as the synthesis and study of the various exo- and endo derivatives of fullerenes’ properties, including C60 complex compounds with transition metals and fullerenes, which, inside their carbon networks, contain atoms of various chemical elements, such as lanthanum and others.
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Pitman, Curitis, and Xiupeng Li. "Preface: 2022 International Conference on Management Engineering and Economic Analysis (MEEA 2022)." BCP Business & Management 34 (December 14, 2022): I. http://dx.doi.org/10.54691/bcpbm.v34i.2709.
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The 2022 International Conference on Management Engineering and Economic Analysis (MEEA 2022) was held in London, UK during September 24-25, 2022. This conference is to bring together innovative academics and experts in the fields of management engineering, business statistics, marketing strategies, financial economics and economic analysis to a common forum. The primary goal of the conference is to promote research and developmental activities and another goal is to promote information interchange between researchers, developers, engineers, students, and practitioners working all around the world.
The conference will be held every year to make it an ideal platform for people to share views and experiences in related areas. The conference model of MEEA 2022 was divided into two sessions, including oral presentations and keynote speeches. In the first part, some scholars, whose submissions were selected as the excellent papers, were given 10-15 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 35-45 minutes to hold their speeches. More than 280 participants attended the meeting. There were over 16 experts and scholars in the area of management engineering, business statistics, and economic analysis representing different famous universities and institutes around the globe.
We are glad to share with you that we received lots of submissions from the conference and we selected a bunch of high-quality papers and compiled them into the proceedings after rigorous reviewing. All the papers have been through rigorous review and process to meet the requirements of international publication standard.
We are really grateful to the keynote speakers, session chairs, organizing committee members, student volunteers and publication house. Also, we are thankful to all the authors for contributing a large number of papers in the conference. It was the quality of their presentations and their passion to communicate with the other participants that really make this conference series a great success.
MEEA 2022 Organizing Committees
London, UK
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Deng, Ruishu, Christian Hurtz, Chanyu Yue, Gang Xiao, Hua Yu, Markus Muschen, Stephen J. Forman, Paul J. Martin, and Defu Zeng. "Extrafollicular CD4+ T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation." Blood 126, no. 23 (December 3, 2015): 1875. http://dx.doi.org/10.1182/blood.v126.23.1875.1875.
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Abstract Chronic graft-versus-host disease (GVHD) in patients with allogeneic hematopoietic cell transplantation (HCT) is an immune-mediated syndrome. Both CD4+ T and B cells are required for disease induction, but details of this interaction have not been fully defined. Other groups have reported that germinal centers are enlarged in mice with chronic GVHD and that GC formation is required for induction of the disease. On the other hand, patients with chronic GVHD have a predominance of IgG1 in the serum with little evidence of IgG somatic hypermutation by one year after HCT, suggesting a lack of GC formation (Suzuki et al: Blood. 1996;87:1873-1880; Glas et al: Blood. 2000; 96:1064-1069). Consistently, we observed that GCs were not detectable in mice with chronic GVHD, including MHC-matched C57BL/6 (H-2b) recipients given LP/J (H-2b) grafts and BALB/c (H-2d) recipients given DBA/2 (H-2d) or B10D2 (H-2d) grafts, and MHC-mismatched BALB/c (H-2d) recipients given C57BL/6 (H-2b) grafts. Furthermore, BALB/c recipients given grafts from BCL6-deficient (BCL6 fl/fl Mb1-Cre) C57BL/6 (H-2b) donors lacking the ability to form GC developed chronic GVHD with similar severity to recipients given control BCL6-sufficient grafts. Consistent with lack of GC formation, recipients of BCL6-deficient grafts had profound reduction of serum IgG2b and IgG2c but moderate reduction of IgG1 as compared to recipients given control BCL6-sufficient grafts. The presence of IgG1 indicates extrafollicular CD4+ T and B interaction, which is Stat-3 dependent. Further experiments showed BALB/c recipients given grafts from Stat3-deficient (Stat-3 fl/fl CD4-Cre) C57BL/6 donors did not develop chronic GVHD. Taken together, these results indicate that GC formation is not required for development of chronic GVHD and that extrafollicular CD4+ T and B interaction can induce chronic GVHD. This work is supported by NIH R01 AI066008 and The Beckman Research Institute Excellence Award (to D. Zeng). Disclosures Forman: Mustang: Research Funding; Amgen: Consultancy. Martin:Neovii: Research Funding; RegImmune: Research Funding; Enlivex: Consultancy; Janssen: Consultancy; Pfizer: Consultancy; Pharmacyclics: Consultancy.
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Zilberman-Rudenko, Jevgenia, Hiroshi Deguchi, Mohammed Hayat, Meenal Shukla, Jennifer Nagrampa Orje, Zihan Guo, Tine Wyseure, et al. "Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo." Blood 134, Supplement_1 (November 13, 2019): 3632. http://dx.doi.org/10.1182/blood-2019-129312.
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Thrombin generation and fibrin formation can cause occlusive thrombosis and myocardial infarction is caused by occlusive thrombi. Exposure and release of cardiac myosin (CM) are linked to myocardial infarction, but CM has not been accorded any thrombotic functional significance. Skeletal muscle myosin (SkM), which is structurally similar to CM, was previously shown to exert procoagulant activities (Deguchi H et al, Blood. 2016;128:1870), leading us to undertake new studies of the in vitro and in vivo procoagulant activities of CM. First, the setting of hemophilia A with its remarkable bleeding risk was used to evaluate the procoagulant properties of CM. In studies of human hemophilia plasma and of murine acquired hemophilia A plasma, CM was added to these plasmas and tissue factor (TF)-induced thrombin generation assays were performed. Plasmas included human hemophilia A plasma and C57BL/6J mouse plasma with anti-FVIII antibody (GMA-8015; 5 microgram/mL final). CM showed strong procoagulant effects in human hemophilia A plasma, which is naturally deficient in factor VIII (<1% FVIII). The addition of only CM (12.5-200 nM) greatly increased thrombin generation in a manner comparable to addition of only recombinant FVIII. In the wild-type C57BL/6J mouse plasma, anti-FVIII antibody greatly reduced TF-induced thrombin generation, as reported. When CM (12.5-200 nM) was added to mouse plasma containing anti-FVIII antibodies, TF-induced thrombin generation was concentration-dependently restored. To study the in vivo hemostatic ability of SkM, an acquired hemophilia A mouse model was employed. Intravenous injection of anti-FVIII antibody (GMA-8015; 0.25 mg/kg) or control vehicle was given retro-orbitally to wild type C57BL/6J mice at 2 hours prior to tail cutting. The distal portion of the tail was surgically removed at 1.5 mm tail diameter to induce moderate bleeding. Tails were immersed in 50 mL of saline at 37 degrees. Total blood loss was measured as the blood volume collected during 20 min normalized for mouse weight (microL/g). Mice given only anti-FVIII antibody had more blood loss (median = 6.7 microL/g) compared to control mice (median < 2 microL/g) (Figure). In this mouse model receiving anti-FVIII antibody, CM (5.4 mg/kg) injected at 15 min prior to tail cutting significantly reduced the median blood loss from 6.7 to 2.0 and 3.2 microL/g, respectively (p < 0.001 for each myosin) (Figure). Thus, these studies provide in vivo proof of concept that both CM and SkM can reduce bleeding and are procoagulant in vivo. Second, studies of the effects of CM on thrombogenesis ex vivo using fresh human flowing blood showed that perfusion of blood over CM-coated surfaces at 300 s-1 shear rate caused extensive fibrin deposition. Addition of CM to blood also promoted the thrombotic responses of human blood flowing over collagen-coated surfaces, evidence of CM's thrombogenicity. Further studies showed that CM enhanced thrombin generation in platelet rich plasma and platelet poor plasma, indicating that CM promotes thrombin generation in plasma primarily independently of platelets. To address the mechanistic insights for CM's procoagulant activity, purified coagulation factors were employed. In a purified system composed of factor Xa, factor Va, prothrombin and calcium ions, CM greatly enhanced prothrombinase activity. Experiments using Gla-domainless factor Xa showed that the Gla domain of factor Xa was not required for CM's prothrombinase enhancement in contrast to phospholipid-enhanced prothrombinase activity which requires that Gla domain. Binding studies showed that CM directly binds factor Xa. In summary, here we show that CM is procoagulant due to its ability to bind factor Xa and strongly promote thrombin generation. In summary, CM acts as procoagulant by its ability to bind factor Xa and strongly promote thrombin generation both in vivo an in vitro. These provocative findings raise many questions about whether and how the protective pro-hemostatic properties or the pathogenic prothrombotic properties of CM contribute to pathophysiology in the coronary circulation. This discovery raises many questions about CM and coronary pathophysiology, and future CM research may enable novel translations of new knowledge regarding CM's procoagulant activities for coronary health and disease. Figure Disclosures Mosnier: The Scripps Research Institute: Membership on an entity's Board of Directors or advisory committees, Patents & Royalties. Ruggeri:MERU-VasImmune Inc.: Equity Ownership, Other: CEO and Founder.
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DeArmitt, Pleshette. "Cascade of Remainders." Derrida Today 9, no. 2 (November 2016): 97–106. http://dx.doi.org/10.3366/drt.2016.0127.
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In a very late essay on remains, one might say a throw away essay, Derrida doggedly tracks the relation of a certain desire to remains, linking it to sacrificial economy and to a hierarchical ontological order. If our concern is a thinking of desire as it pertains to remains, why should we not turn first, or perhaps exclusively, to Derrida's monumental works on the subject of remains, specifically Glas and Cinders, jettisoning the little-known essay we have not yet named? Certainly Derrida has said much in these well-known works about desire and remains, consumption and excretion, fire and ashes. So, why devote all one's attention, as we will do in this paper, to what might be said to be a morsel of an essay, which has remained largely unread and hence falls outside of Derrida commentary? The essay in question is his 2002 ‘Remains – the Master, or the Supplement of Infinity’, a homage to Charles Malamoud, a French ethnologist and scholar of Indian and Oriental religions whose work, especially his 1989 Cooking the World, was influential on Derrida's thinking concerning the ‘rhetorics of cannibalism’ and ‘eating the other’ and featured prominently in his seminars from 1989–1991 on the aforementioned themes. In ‘Remains – the Master’, a dense and rich essay, Derrida analogically links two vastly different cultures – the Brahmanic of India and the Greco-European – in terms of a ‘law of remainders’, which for both traditions, he claims, is an organizing principle of humans, gods, and the whole of the world. In his essay Derrida returns to or, more accurately, remains with a thinking of ‘the French word “reste”, the remnants [restance] of “reste”’, which, as Derrida notes, is ‘difficult to translate in an exhaustive or transparent manner,’ that is, ‘without remainder’ (2002, 41). However, what this paper will follow is the circulation of remainders in the Vedic tradition, as analysed by Derrida and Malamoud. In doing so, we can begin to not only translate the notion of Malamoud's ‘cascade de restes’ from one culture, logic, and idiom to another but understand how for Derrida this ritual downpour of remainders not only institutes a hierarchy of remainders but also produces ipseity.
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Ubaid, Muhammad, Ahsan Mobin, Imtiaz Manzoor, Muhammad Rehan, and Zahid Qadri. "A Study on Etiology, Clinical Features and Complications of Chronic Kidney Disease Patients." Pakistan Journal of Medical and Health Sciences 16, no. 10 (October 30, 2022): 488–91. http://dx.doi.org/10.53350/pjmhs221610488.
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Background and Aim: Chronic kidney disease (CKD) is a major health issue that encompasses a variety of pathophysiological processes mostly related to declining rate of glomerular filtration and abnormal kidney function. Globally, the incidence of chronic kidney disease is increasing due to hypertension, diabetes, and cardiovascular disease. The present study aimed to investigate the etiology, clinical features, and complications of chronic kidney disease patients. Methodology: This cross-sectional study was conducted on 136 chronic kidney disease patients admitted to the Department of Medicine of Mamji Hospital, Karachi Pakistan from January 2021 to December 2021. Prior to study conduction, ethical approval from the research and ethical committee of the institute was taken. Informed consent was obtained from each individual. Demographic details, para-clinical and clinical features, etiology, and therapeutic features were the different outcome variables. Clinical examinations with detailed history and laboratory investigations were assessed. For laboratory examinations, urine and blood samples from each participant were taken. Data analysis with detailed descriptive statistics was carried out in SPSS version 25. Results: Out of 136 CKD patients, there were 74 (54.4%) male and 62 (45.6%) females. The overall mean age was 38.6±4.8 years. Age-wise distribution of the participants was as: 23 (16.9%) 15-25 years, 38 (27.9%) 26-35 years, 34 (25%) 36-45 years, 26 (19.1%) 46-55 years, and 15 (11.1%) >55 years. The chronic kidney disease associated comorbidities were high blood pressure (HBP) 64 (47.1%), human immunodeficiency virus (HIV) 25 (18.4%), Diabetic sugar 21 (15.4%), heart disease 19 (14%), and sickle cell anemia 7 (5.1%). Lesion diagnosis was found in 61 (44.9%) patients. The most prevalent diagnosis was chronic glomerulonephritis (CGN), Glam nephropathy, and vascular nephropathies presented in 27 (19.9%), 18 (13.2%), and 16 (11.8%) respectively. Intermediate 69 (50.7%), Hypertensive nephropathy 20 (14.7%), HIV-related nephropathy 17 (12.5%), Diabetic nephropathy 15 (11%), Primary segmental and focal hyalinosis 11 (8.2%), and Autosomal dominant polycystic kidney disease 4 (2.9%) were the different etiology diagnosed in CKD patients. The chronic disease complications such as Anemia, hyperkalaemia, hyperuricemia, uremic encephalopathy, right femoral venous thrombosis, and acute pulmonary edema were seen in 107 (78.7%), 54 (39.7%), 13 (9.6%), 9 (6.6%), 2 (1.5%), and 8 (5.9%) respectively. Conclusion: The present study concluded that hypertension, cardiovascular disease, diabetes, and HIV are the different predominant risk factors for chronic kidney disease. Also, the most prevalent etiology of the CKD was chronic glomerulonephritis (CGN) followed by Diabetic nephropathy in CKD patients. Anemia was the prevalent complication followed by hyperkalemia and hyperuricemia. Swelling at lower limb and weakness were the common symptoms of chronic kidney disease. Keywords: Etiology, Clinical features, Complications, Chronic Kidney Disease.
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Voloshchuk, I. S., O. P. Voloshchuk, V. V. Hlyva, and M. O. Pashchak. "Economic efficiency of maize grain production under various agrotechnical measures of cultivation." Scientific Journal Grain Crops 6, no. 1 (August 15, 2022): 148–59. http://dx.doi.org/10.31867/2523-4544/0218.
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Topicality. The efficiency of the grain production industry allows to provide the population with food and the state with currency. A significant place in the increase in the volume of grain crops is assigned to maize, which is in stable demand both in the domestic and foreign markets. Issues. Due to the lack of programs of grain maize breeding in the Western Forest-Steppe zone, it is necessary to purchase the hybrids and seed material in the originating institutions of the Central Forest-Steppe and Steppe zones. The choice of high-yield hybrids depends on their biological char-acteristics, effective use of soil and climatic conditions and positive response to the cultivation technology. Aim. To conduct a comprehensive and economic evaluation of maize hybrids depend-ing on the implementation of their genetic potential in the soil and climatic conditions of the West-ern Forest-Steppe and their response to the system of basic and foliar plant nutrition. Materials and methods. The studies were carried out during 2019–2021 on the fields of the Department of Seed Production and Seed Science at the Institute of Agriculture in the Carpathian region NAAS. We studied next maize hybrids: Pochaivskyi 190 MV, DN Meotyda, DN Khortytsia, Orzhytsia 237 MV (the originator – State Enterprise Institute of Grain Crops of NAAS, Dnipro). Yield accounting was carried out by direct combining of experimental plots with subsequent weighing, and the obtained data was recalculated for standard grain moisture content. Processing statistical data - by analysis of variance (Excel, Statistica 6.0) according to V. A. Ushkarenko, R. A. Vozhehova, S. P. Golobo-rodko, S. V. Kokovikhin (2013), economic assessment – by the method of V. I. Boiko, E. M. Lebid, V. S. Rybka (2008). Results. The highest grain yield of maize hybrids (7.49 t/ha for early-ripening group and 7.62 t/ha for mid-early group) was obtained in 2019; in 2020, the grain yield was lowest – 7.07 and 7.22 t/ha, respectively. The highest yield of 7.68 t/ha was obtained for DN Meotyda hy-brid of the early ripening group, and 7.67 t/ha – for Orzhytsia 237 MV hybrid of the mid-early rip-ening group. Over the years of research, the variability of grain yield for the early ripening hybrids (FAO 100–199) ranged within 0.32–0.52 t/ha, for the mid-early ripening hybrids (FAO 200–299) – 0.22–0.35 t/ha. Pre-sowing seed treatment with chelated forms of microfertilizers was effective on gray forest surface-gley soils of the studied region with hard-to-reach forms of nutrients. Microferti-lizers used in pre-sowing seed treatment increased grain yield by 0.21–0.43 t/ha. Conclusions. The growth of economic indicators for farms of various forms of ownership in the Western Forest-Steppe zone is facilitated by the expansion of the range of simple linear maize hybrids of domestic selection. When growing ecologically plastic maize hybrids of different maturity groups (Pochaivskyi 190 MV, DN Meotyda, DN Khortytsia, Orzhytsia 237 MV), the profitability of grain production reached 107.2–132.1 %. Pre-sowing seed treatment with chelated microfertilizers: Ora-cle Seeds (1.0 l/t), Brexil Combi (0.5 kg/t) and Valagro EDTA Mix 5 (0.2 kg/t) increased the profit-ability by 2.7–9.2 %. When applying microfertilizer Oracle Multicomplex (1.5 l/ha) in the stage of ВВСН 16–18 (6–8 leaves) and ВВСН 59 (tasseling), the profitability indicator exceeded the control (without foliar feeding) by 37.1–38.2 %. When the rate of application of mineral fertilizers was in-creased to N150P90K90, it was obtained a higher profitability of grain production of early ripening maize hybrids (FAO 100–199) at plant density of 75 thousand pcs/ha) by 24.6–27.7 %, mid-early ripening (FAO 200–299 with plant density of 80 thousand pcs/ha) – by 17.4–20.7 % compared to N120P90K90. Key words: maize, yield, microfertilizers, mineral fertilizers, profitability.
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Nguyen, Phuong Khanh, Thomas D. Dieringer, Adela Greeley, Suny Kun, Feliza Calub, My-Phuong Pham, Christopher J. Graber, Matthew B. Goetz, Matthew B. Goetz, and Kevin Ikuta. "533. Protocol for and Efficacy of Monoclonal Antibody (mAb) Treatment of SARS-CoV-2 at a VA Medical Center." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S367—S368. http://dx.doi.org/10.1093/ofid/ofab466.732.
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Abstract Background Bamlanivimab and casirivimab/imdevimab were the first monoclonal antibodies (mAb) developed against SARS-CoV-2 and proved beneficial early in the course of infection. However, real-world administration of these therapies presents logistical challenges. We present our experience implementing mAb treatment at a large VA Medical Center and review the efficacy of therapy in preventing hospitalization from COVID-19 in a closed healthcare system. Methods All positive outpatient COVID tests performed at VA Greater Los Angeles Healthcare System (GLA) were reviewed by the Emergency Medicine (EM) and Infectious Diseases (ID) Sections for mAb eligibility beginning 12/2/2020. Due to limited supply, treatment was prioritized for patients at highest risk of developing severe disease, as determined by EM/ID with input from a machine learning ensemble risk estimation model produced by VA National Artificial Intelligence Institute (Figure 1). If a patient declined or did not reply, treatment was offered to the next patient on a ranked eligibility list. Those who declined or were eligible but not treated were included in the analysis. Patients were excluded if they were hospitalized before treatment was offered. We collected data on age, comorbidities, date of diagnosis, and admission at 30 days after diagnosis. A multivariate log binomial regression was performed to determine the relative risk of admission within 30 days of diagnosis for those who received mAb therapy as compared to those who did not, adjusting for age and comorbidity. All analysis was done in R (version 4.0.5). Results 139 patients met inclusion criteria. 45 (32%) received mAb therapy, 48 (35%) declined mAb therapy, and the remaining 46 (33%) either did not respond or were not offered mAb therapy. Hospitalizations following diagnosis in each group are illustrated in Figure 2. There was a trend towards reduced absolute and relative risk of hospitalization (Table 1). There were no anaphylactic events in patients who received mAb therapy. Conclusion At our facility, a system for rapid identification of candidates and a coordinated distribution plan was essential in ensuring timely administration of mAb therapy to eligible patients. Administration of mAb showed a trend towards decreased risk of hospitalization due to SARS-CoV-2. Disclosures Adela Greeley, MD, Kite (Other Financial or Material Support, My spouse is an employee) Matthew B. Goetz, MD, Nothing to disclose
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Dumon, JC, H. Wantier, F. Mathieu, M. Mantia, and JJ Body. "Technical and clinical validation of a new immunoradiometric assay for human osteocalcin." European Journal of Endocrinology 135, no. 2 (August 1996): 231–37. http://dx.doi.org/10.1530/eje.0.1350231.
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Dumon JC, Wantier H, Mathieu F, Mantia M, Body JJ, Technical and clinical validation of a new immunoradiometric assay for human osteocalcin. Eur J Endocrinol 1996;135:231–7. ISSN 0804–4643 The measurement of circulating osteocalcin or bone GLA protein (BGP) constitutes a well established and non-invasive means for evaluating preferentially the bone formation rate, but most available commercial assays suffer from several technical constraints, notably a rapid degradation of BGP at room temperature or after thawing and the inability to measure subnormal values. We evaluated, from a technical and a clinical viewpoint, a newly available two-site sandwich immunoradiometric assay (IRMA) using standards of human origin and two different monoclonal antibodies. The theoretical and functional assay detection limit was 0.3 ng/ml. Concentrations of BGP progressively decreased when the serum was left at 4°C or at room temperature (mean apparent loss of 15% after 24 h). Two cycles of freezing–thawing only slightly reduced the BGP concentrations. The mean (± sd) BGP concentration was 19.6 ± 7.9 ng/ml in healthy subjects (NI, N = 61); the normal range was 8.1–35.6 ng/ml. There was a marked difference between pre- and postmenopausal women: 15.1 ±4.4 vs 22.3 ± 8.4 ng/ml, respectively (p<0.05). The mean BGP concentration in patients with tumor-induced hypercalcemia (N = 29) was not significantly different from NI, but nine patients (31%) had subnormal levels and five (17%) had elevated BGP levels. Concentrations of BGP were significantly increased in patients with hyperparathyroidism (N = 14) (45.1 ± 21.0 ng/ml) and significantly lower than NI in patients with hypoparathyroidism (N = 18) (7.3 ± 4.6 ng/ml). Concentrations of BGP were also measured by a classical radioimmunoassay using bovine standards and tracer; the correlations between both sets of measurements were significant in all groups, except in patients with hypoparathyroidism. In summary, this newly available IRMA for measuring circulating human BGP appears to be quite sensitive, reproducible and robust. It should be especially useful for investigating clinical conditions characterized by a low bone formation rate. JJ Body, Institut Jules Bordet, Rue Héger-Bordet 1, 1000 Brussels, Belgium
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Čufar, Katarina, and Jože Kropivšek. "Editorial." Les/Wood 69, no. 1 (June 20, 2020): 3–4. http://dx.doi.org/10.26614/les-wood.2020.v69n01a00.
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This issue of the journal Les/Wood is special for several reasons. Most of the related activities were carried out during the Covid-19 lockdown, which was very challenging for our authors, reviewers and editorial board. However, despite all the inconveniences caused by the pandemic, four eminent scholars from abroad joined the journal and its editorial board. Among them are: Prof. Manuela Romagnoli, PhD, Department of Innovation of Biological Systems, Food and Forestry DIBAF, Tuscia University, Viterbo, Italy; Prof. Denis Jelačić, PhD, Faculty of Forestry, University of Zagreb, Croatia; Krishna K. Pandey, PhD., Institute of Wood Science & Technology, Indian Council of Forestry Research and Education, Bangalore, India; and Alan Crivellaro, PhD, Department of Geography, University of Cambridge, UK. We are glad that they accepted our invitation, and we hope for fruitful further cooperation, which is undoubtedly very important for the international recognition of the journal.
In this issue we are publishing seven scientific articles, four of them in English. We are especially pleased that there are new names among the authors, and young authors in particular. Two of them have already acquired prestigious projects, while another two are at the beginning of their PhD studies and publishing articles in a scientific journal for the first time.
Kavyashree Srinivasa, PhD from India has obtained a project (NewSiest-867451) under the EU research innovation programme H2020, MSC-IF (Marie Skłodowska-Curie – Individual Fellowship), which proves the excellence of her research. As part of the two-year project, she is currently employed at the Department of Wood Science and Technology, Biotechnical Faculty, University of Ljubljana, pursuing detailed post-doctoral research under the mentorship of Prof. Marko Petrič, PhD. She completed a master’s degree in chemistry and obtained her PhD from the Institute of Wood Science & Technology in Bangalore (FRI DU, Dehradun), India. She was a recipient of the Ron Cockcroft award from the International Research Group on Wood Conservation (IRG-WP) in 2013.
Arnaud Maxime Cheumani, PhD from Cameroon has acquired the project “SilWoodCoat”, which bears the “Seal of Excellence” and is funded by the ARRS, a testament to the outstanding nature of both the researcher and the project. He currently works at the Department of Wood Science and Technology, Biotechnical Faculty, University of Ljubljana under the mentorship of Prof. Marko Petrič, PhD., developing silicate-based wood coatings. He is a chemist by basic education, but in his research focusses mainly on polymers and polymer composites connected to wood science. He obtained his PhD from the University of Bordeaux-France in 2009, and is an assistant professor at the University of Yaoundé 1 in Yaoundé in Cameroon. Prior to this he worked on several research projects dealing with wood-cement composites, liquefied wood, development of wood coatings, wood modification with poly (lactic acid) and composites made of natural polymer fibres.
Nina Škrk has been working as a young researcher under the mentorship of Prof. Katarina Čufar, PhD at the Department of Wood Science and Technology, Biotechnical Faculty, University of Ljubljana since the autumn of 2019. She is enrolled in the PhD study of Biosciences, Wood and Biocomposites. In her research she focuses on the effects of climate change in the 21st century on trees and wood. This is her first publication of a scientific article in a scientific journal.
Irena Sochová has been a PhD student at Mendel University in Brno, Czech Republic since November 2019. She works within the Wood Processing and Timber Technology programme with a focus on dendrochronology. The main topic of her dissertation is the oak tree-ring standard chronology as a tool for dendro-archaeological analyses in the Western Ukraine. Currently she is also employed at CAS, the Global Change Research Institute in the Czech Republic. This is her first publication of a scientific article in a scientific journal.
The main feature of this issue is the introduction of the practice of the world’s leading scientific journals regarding open access of their research data, which is basis for (empirical) scientific articles. We joined the activities of the RDA (Research Data Alliance) of the Slovenian hub, which is coordinated by the Social Science Data Archive with the support of the RDA EU 4.0 project. Thus, one of the articles in this issue (Škrk et al., 2020) is accompanied by the publication of the scientific data (photographs), which are freely available through the Repository of the University of Ljubljana (RUL). In publishing the data we were guided by Mojca Kotar, PhD from University Library Services, University of Ljubljana, Janez Štrebe, PhD from the Faculty of Social Science, University of Ljubljana, by Sebastian Dahle, PhD from Department of Wood Science and Technology, University of Ljubljana, and by Darja Vranjek from INDOK, Department of Wood Science and Technology, Biotechnical Faculty, University of Ljubljana. Thank you all for your work, we truly appreciate your efforts.
Special thanks go to all the reviewers of the Les/Wood journal, who did excellent job once again in a very short time. In addition, we would like to thank the technical support team, proof-readers Paul Steed and Darja Vranjek, librarian Maja Valič, technical editor Anton Zupančič and designers from DECOP d.o.o., Železniki.
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Franiak-Pietryga, Ida, Ewelina Ziolkowska, Barbara Ziemba, Dietmar Appelhans, Brigitte Voit, Joanna Gora-Tybor, Tadeusz Robak, Barbara Klajnert, and Maria Bryszewska. "Nanoparticles – a Novel Approach to Chronic Lymphocytic Leukemia Treatment?" Blood 120, no. 21 (November 16, 2012): 4601. http://dx.doi.org/10.1182/blood.v120.21.4601.4601.
Full textAbstract:
Abstract Abstract 4601 Treatment of chronic lymphocytic leukemia (CLL), including conventional therapy based on alkylating agents, purine nucleoside analogues (cladribine, fludarabine (FA)) or monoclonal antibodies (rituximab (Rit), alemtuzumab), significantly improved overall and complete responses. Although there are many treatment possibilities, this disease still remains incurable. Therefore, searching for new therapeutical strategies in CLL is vital. Nanotechnology, a new and promising field of scientific research, may be of use in medicine and the pharmaceutical industry. Dendrimers, nanoparticles (polymers) of dendritic architecture, used as carriers of drugs, nucleic acid and photosensitizers for targeted delivery, contrast agents in magnetic resonance imaging (MRI) have already been reported. It seems likely that dendrimers themselves might be damaging for neoplastic cells. The aim of our study was to preliminarly assess the clinical value of treating CLL patients with poly(propylene imine) (PPI) dendrimers. The assessment was based on the in vitro induction of cytotoxicity and apoptosis by fourth generation PPI dendrimers, with the surface amino groups substituted with maltotriose [Mal-III] residues. PPI-G4-OS-Mal-III dendrimers have, in contrast to the parental cationic PPI-G4, a virtually neutral surface charge. Therefore, they are preferentially involved in H-bond driven interactions. The study was conducted in 15 untreated CLL patients (7 men, 8 women) who were diagnosed in accordance with IWCLL criteria and followed at the Hematology Department, Medical University, Lodz, Poland. The Ethics Committee of the Medical University of Lodz, Poland approved the study (RNN/75/10/KE). Informed consent was obtained from all patients involved in the study. The mean age of CLL patients was 63.80 yrs. Peripheral blood mononuclear cells (MNCs) were separated from EDTA fresh blood. MNCs were incubated with dendrimers at concentrations of 4, 6 and 8 mg/ml. The cultures without dendrimers served as controls. Dendrimers in which approximately 35% of peripheral amino groups were coated with Mal-III (Leibniz Institute of Polymer Research, Dresden, Germany) have been defined as PPI-G4-OS-Mal-III. The abbreviation OS describes the open shell structure of carbohydrate-modified dendrimers (Fig. 1). The molar mass of this PPI dendrimer was 31000 g/mol. Apoptosis was measured by the Annexin-V/Propidium Iodide test. A decrease in mitochondrial membrane potential (one of the earliest events in the apoptotic pathway) was evaluated by the CMXRos technique, using flow cytometry. The percentage of cells with lower mitochondrial membrane potential (MMP) (DYmlow/Gly-A−) was determined. The percentage of apoptotic MNCs induced by PPI-G4-OS-Mal-III after 24 h and 48 h incubations was significantly higher than the percentage of spontaneous apoptotic leukemic cells. PPI glycodendrimers induced MNC apoptosis to a greater degree after 48 h than 24 h. The largest differences were observed for Ann-V+JP+ cells at a concentration of 8 mg/ml (p = 0.007). The IC50 value after 48-h-incubation was calculated as 8.24 mg/ml. Moreover, the CMXRos technique revealed apoptosis induction by PPI-G4-OS-Mal-III at each examined concentration in comparison with control cultures (Table 1). Table 1. 24h Control PPI-G4-OS-Mal-III 4 mg/ml PPI-G4-OS-Mal-III 6 mg/ml PPI-G4-OS-Mal-III 8 mg/ml FA 1.6 μM Rit 10 μg/ml X 23.7 51.0 60.1 64.4 62.9 28.0 48h X 28.3 67.8 71.9 79.3 89.0 29.4 X – mean percentage of cells with lower mitochondrial potential (DYmlow/Gly-A− [%]) Finally, PPI-G4-OS-Mal-III was not observed to have any harmful effects on erythrocytes (RBCs) or platelets (PLTs). The studied dendrimer induced PLT aggregation at a concentration of 50 mg/ml. Hemolysis induced by the PPI-G4-OS-Mal-III dendrimer is not important from the biological point of view. To summarise, the PPI-G4-OS-Mal-III dendrimer demonstrated higher cytotoxicity towards CLL cells than healthy donor cells. Its potency to trigger apoptosis is similar to many PNAs and monoclonal antibodies widely used in CLL therapy. Thus, dendrimers are a potential tool for CLL treatment. The study was partially supported by Grant No. DEC-2011/01/B/NZ5/01371 from the National Science Centre, Poland. Fig. 1. Fig. 1. Disclosures: No relevant conflicts of interest to declare.