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1

Engin, Kaya N., Cemil Yılmazlı, Günay Engin, and Levent Bilgiç. "Results of Combined Cyclectomy/Trabeculectomy Procedure Compared with Ahmed Glaucoma Valve Implant in Neovascular Glaucoma Cases." ISRN Ophthalmology 2011 (December 8, 2011): 1–6. http://dx.doi.org/10.5402/2011/680827.

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Purpose. Cyclectomy/trabeculectomy and Ahmed glaucoma valve implant are operations suggested for refractory glaucomas. In this study, we have evaluated the outcomes that we observed with these two techniques in neovascular glaucoma patients. Material and Methods. Thirty-five eyes with neovascular glaucomas were included in this study. Ahmed Glaucoma valve (group A) was applied to ten eyes, while cyclectomy/trabeculectomy was applied to 25 eyes (group C/T). Vision, intraocular pressure and complications were evaluated at the end of the first week and after 6 and 12 months. Results. Vision preservations were 80% and 92%, and success rates in reducing intraocular pressure were 50% and 72% for Ahmed glaucoma valve and cyclectomy/trabeculectomy groups, respectively. None of the differences in complication rates was found to be statistically significant. Conclusions. In the surgical management of neovascular glaucoma, cyclectomy/trabeculectomy was shown to be an alternative to Ahmed glaucoma valve operation.
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McDowell, Colleen M., and Michael G. Anderson. "Toward a Genetic Understanding of Glaucoma—Breakthroughs and Challenges from Studies of Exfoliation Glaucoma." US Ophthalmic Review 04, no. 01 (2011): 23. http://dx.doi.org/10.17925/usor.2011.04.01.23.

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Glaucoma is a complex group of diseases causing progressive degeneration of the optic nerve. Despite strong evidence of hereditary contributions to glaucoma, relatively few genetic mutations associated with glaucoma risk have thus far been identified. Glaucoma likely represents a complex genetic trait influenced by multiple loci and many confounding factors, increasing the challenge in identifying glaucoma’s hereditary basis. In this article, a brief history of the search for glaucoma-causing mutations is presented, highlighting recent breakthroughs that have identified lysyl oxidase-like 1 (LOXL1) as a major genetic risk factor contributing to exfoliative glaucoma. In considering challenges that remain ahead, our central tenet is that the search for glaucoma’s genetic elements will continue to require experimental ingenuity and synergistic approaches involving animal models that render the complexity of glaucoma more tractable.
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3

Calugaru, Dan. "Intraocular pressure modifications in patients with acute central/hemicentral retinal vein occlusions." International Journal of Ophthalmology 14, no. 6 (June 18, 2021): 931–35. http://dx.doi.org/10.18240/ijo.2021.06.20.

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Intraocular pressure (IOP) modifications in patients with acute central/hemicentral retinal vein occlusions (RVOs) consist in IOP reductions and increases. The IOP reduction is due to a transitional hyposecretory phase of the aqueous humor, that increases gradually until 3mo after the venous occlusion onset, and then finally disappears after month 4th. The IOP increases lead to the ocular hypertension and glaucoma. The possible pathogenetic correlations between ocular hypertension/glaucoma and acute central/hemicentral RVOs have been classified into three groups: 1) the venous occlusion precedes the ocular hypertension/glaucoma causing neovascular glaucoma and secondary angle-closure glaucoma without rubeosis; 2) the ocular hypertension and the glaucoma precede the venous occlusion and favor its appearance (ocular hypertension, primary angle-closure, primary angle-closure glaucoma, and open angle glaucomas); and 3) the venous occlusion and the ocular hypertension/glaucoma are mostly age dependent appearances due to common vascular and collagen alterations, lacking a causal connection between the 2 conditions.
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Díaz, Esperanza Gutiérrez, Enrique Mencía Gutiérrez, and Pilar Tejada Palacios. "The Role of Glaucoma Drainage Devices in Paediatric Glaucoma." European Ophthalmic Review 06, no. 04 (2012): 208. http://dx.doi.org/10.17925/eor.2012.06.04.208.

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Glaucoma drainage devices may be indicated in glaucoma associated to complex congenital anomalies or dysgenesis of the anterior segment, secondary glaucomas such as those developed after congenital cataract surgery, severe primary congenital glaucoma after failed angle surgery and in eyes with severe conjunctival scarring. They can be combined with several other procedures, such as cataract extraction, intraocular lens implantation, keratoplasty or pars plana vitrectomy. This procedure may achieve a sustained and prolonged intraocular pressure reduction in children, with early post-operative success as high as 90 %, although it decreases over time, to 40–60 % survival at 4–6 years using the Kaplan-Meier analysis and most children need to reinitiate glaucoma treatment postoperatively. We must bear in mind that complications may occur, especially tube malposition and exposure, and multiple repeated surgeries may be necessary. The advantages and complications should be weighed in each individual case.
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5

Zia, Rashid. "editorial." Pakistan Journal of Ophthalmology 35, no. 4 (January 23, 2020): 215–16. http://dx.doi.org/10.36351/pjo.v35i4.988.

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Glaucoma, is a group of conditions characterized by optic disc cupping and visual field defects. Evaluation, staging and monitoring of glaucoma requires a series of functional tests which is a time consuming process. So far, Standard Automated Perimetry (SAP) is recognized as a reference standard for all the functional testing1. Glaucoma may present with a structural or a functional change. Therefore, the correct test strategy for diagnosis is vital to prevent overlooking the onset of glaucoma2.
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6

Abeshi, Andi, Francesca Fanelli, Tommaso Beccari, Munis Dundar, Lucia Ziccardi, and Matteo Bertelli. "Genetic testing for Mendelian glaucoma." EuroBiotech Journal 1, s1 (October 27, 2017): 70–73. http://dx.doi.org/10.24190/issn2564-615x/2017/s1.22.

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Abstract We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for Mendelian glaucomas, a large heterogeneous group of inherited disorders, classified according to age of onset as congenital glaucoma, juvenile glaucoma and age-related glaucoma. Variations in the TEK, MYOC, ASB10, NTF4, OPA1, WDR36 and OPTN genes are inherited in an autosomal dominant manner and variations in the CYP1B1 and LTBP2 genes have autosomal recessive inheritance. The prevalence of congenital glaucoma is estimated at 1-9 per 100 000, that of juvenile glaucoma at 1 per 50 000, while there is insufficient data to establish the prevalence of age-related glaucoma. Clinical diagnosis is based on clinical findings, age of onset, family history, ophthalmological examination, intraocular pressure, gonioscopy and fundoscopy. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
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7

Castro, Ana Flávia Nogueira, and Lívia Oliveira Delgado Mota. "Uma abordagem geral do Glaucoma: revisão de literatura." Revista Eletrônica Acervo Médico 20 (November 4, 2022): e11136. http://dx.doi.org/10.25248/reamed.e11136.2022.

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Objetivo: Analisar as características do Glaucoma. Revisão bibliográfica: O glaucoma é um grupo de doenças cuja característica comum é a degeneração progressiva do nervo óptico, com perda de células ganglionares da retina, afinamento da camada de fibras nervosas da retina e aumento da escavação do disco óptico. Os sintomas visuais costumam ser uma característica tardia do glaucoma, quando a doença já está muito avançada. Dentre os muitos tipos de glaucoma, os mais frequentes são os glaucomas primários de ângulo aberto (GPAA) e de ângulo fechado (GPAF). Estima-se que 4,5 milhões ou mais de 12% de todos os casos de cegueira em todo o mundo foram resultado de glaucoma. Considerações finais: O Glaucoma é uma doença que cursa com redução da acuidade visual e, consequentemente, declínio da qualidade de vida dos pacientes. Embora o glaucoma progrida, geralmente, de forma lenta, é a causa mais comum de cegueira evitável irreversível no mundo. Dessa forma, é fundamental a conscientização acerca da doença a fim de propiciar o diagnóstico de forma mais precoce possível com tratamento adequado instituído pelo oftalmologista a fim de evitar a progressão do glaucoma.
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8

Loayza-Gamboa, Waldo. "Glaucomas secundarios." Diagnóstico 62, no. 1 (April 23, 2023): e437. http://dx.doi.org/10.33734/diagnostico.v62i1.437.

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Los glaucomas secundarios (GS) son un grupo de glaucomas causados por factores sistémicos y/o desórdenes oculares que producen hipertensión ocular y posterior daño del nervio óptico. Su etiología es muy variada, entre ellas: trauma ocular, uveíticos, pseudoexfoliativos, inducidas por cirugía ocular, retinopatia diabética, inducidas por el cristalino, relacionadas a medicamentos, principalmente corticoides, tumores, entre otros. Se estima que son alrededor de 6 millones de personas que tienen GS comparado con los 67 millones de personas con glaucoma primario alrededor del mundo. Desde el punto de vista epidemiológico y de intervención médica los más importantes son: los glaucomas secundarios a pseudoexfoliación, los glaucomas neovasculares y los glaucomas uveíticos. Realizamos una revisión actualizada, con los últimos reportes epidemiológicos y avances en genética de estas tres tipo de glaucoma secundario presentando las últimas modalidades de tratamiento farmacológico y quirúrgico.
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9

Sarwade, Prakash Pralhad, Madhav Kumar Mishra, Jyoti, Harpreet Kaur, C. Madhavi Latha, S. Hameedullah Sherief, Kavita Narayan Gaisamudre (Sarwade), Rapborlang Khongshei, and Parmar Hemantbhai Natubhai. "A Detailed Study of Glaucoma in Adults, Its Pathogenesis, Diagnosis and Management." Journal for Research in Applied Sciences and Biotechnology 3, no. 3 (July 21, 2024): 223–30. http://dx.doi.org/10.55544/jrasb.3.3.34.

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As the second most prevalent cause of blindness in the world, after cataracts, glaucoma diagnosis and treatment are crucial topics for general physicians to know. Glaucomas can often be categorised based on three key factors: the extent to which the anterior chamber angle is open or closed, the intensity of the onset (acute or chronic), and the underlying cause (primary or secondary). Most cases of glaucoma are primary, indicating the absence of any comorbidities. Nevertheless, secondary glaucomas may arise from a range of visual illnesses as their root cause. Individuals who are susceptible to developing chronic glaucoma should undergo regular eye examinations in order to detect the condition at an early stage and prevent the progressive deterioration of vision that may occur prior to diagnosis. Glaucoma leads to impairments in both central and peripheral vision fields due to damage to the optic nerve and the retinal nerve fibre layer. All current treatments, including drugs, lasers, and procedures, aim to reduce intraocular pressure (IOP) because it is the only factor that can be changed and is crucial in the progression of the condition. Pharmacotherapy is the usual first-line treatment, although its effectiveness is constrained by noncompliance, adverse effects, and cost. While laser and surgical methods offer the ability to effectively lower intraocular pressure (IOP) for extended periods and at a lower cost compared to medicine, they come with increased risks during the process and a higher likelihood of treatment not being successful. Various modern minimally invasive glaucoma operations have replaced conventional incisional therapies because they offer improved safety and reduced efficacy decreases. While the long-term success of minimally invasive glaucoma surgeries still needs to be determined by large-scale randomised trials, these methods have greatly transformed the surgical treatment of glaucoma.
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10

Hudock, Stephen A. "The Diagnosis and Treatment of Glaucoma." Guthrie Journal 64, no. 1 (March 1995): 4–8. http://dx.doi.org/10.3138/guthrie.64.1.004.

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Although the last 40 years have brought revolutionary changes in our understanding of the glaucomas and in our ability to diagnose and to treat them, the cause still eludes us, as does a cure. Since the most common forms of glaucoma are asymptomatic, we understand better than ever that routine eye examinations are critically important for diagnosing the glaucomas in their early stages, when they can be treated more successfully.
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11

M.N, Nishanth, Susan Philip, and Ambily S. "Incidence of Open Angle Glaucoma among Patients with Pseudoexfoliation Syndrome in a Tertiary Eye Care Centre in South India - A Cross Sectional Study." Journal of Evidence Based Medicine and Healthcare 8, no. 22 (May 31, 2021): 1769–74. http://dx.doi.org/10.18410/jebmh/2021/334.

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BACKGROUND Open angle glaucoma forms a major proportion of glaucomas which is a leading cause of irreversible blindness worldwide. Anatomical variations in ocular structures and consequent secondary open angle glaucoma occurs in significant number of patients afflicted with pseudoexfoliation syndrome. Hence, a detailed workup and identification of glaucoma and appropriate management is essential to prevent further visual loss. We wanted to evaluate the incidence of open angle glaucoma among patients having pseudo exfoliation syndrome at Regional Institute of Ophthalmology, Trivandrum, Kerala. METHODS A cross sectional study comprising 142 individuals with pseudo exfoliation syndrome was conducted in Regional Institute of Ophthalmology, Trivandrum, Kerala, over a period of one year. Sociodemographic variables were collected through structured interviewer administered questionnaire followed by detailed ocular work up and visual field analysis. Data was analysed using Statistical Package for Social Sciences, SPSS 16. RESULTS Among 142 subjects, 70.4 % were males and 29.6 % were females. The mean age of participants was 65 years. In studied population, 83.1 % represented rural population. Incidence of open angle glaucoma among studied population with pseudoexfoliation was 10.56 % (95 % confidence interval; 5.50 % - 15.61 %). No case of normal tension glaucoma was identified during the study period. 29.57 % of subjects showed bilateral pseudoexfoliation. But among patients with pseudoexfoliation (PEX) glaucoma, 78.9 % had bilateral disease. Mean intra ocular pressure in eyes with PEX glaucoma was 27.38 ± 5.75 mm Hg and in PEX eyes without glaucoma was 23.20 ± 1.6 mmHg. Pupillary dilatation was observed to be less than the normal eyes and was 5.62 mm. 4 % of eyes with PEX had some form of zonulopathy. CONCLUSIONS Hospital based incidence of open angle glaucoma among patients with pseudo exfoliation is 10.56 %. KEYWORDS Pseudoexfoliation, Open Angle Glaucoma, Incidence, Intraocular Pressure, Gonioscopy
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12

Mamani Maquera, Diego José, and Nahuel Pantoja Dávalos. "Ghost cell glaucoma: Clinic case." Revista de la Facultad de Medicina Humana 23, no. 1 (January 15, 2023): 121–25. http://dx.doi.org/10.25176/rfmh.v23i1.5061.

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Introduction: Ghost cell glaucoma (GCG) is a very rare secondary open angle glaucoma, in which there is a sustained increase in intraocular pressure (IOP) due to obstruction of the trabecular meshwork (TM) due to the passage of ghost cells (GC) from the vitreous into the anterior chamber, after a vitreous hemorrhage (VH). Clinical Case: We present the case of a male patient with a history of vitreous hemorrhage and sustained IOP elevation in the right eye (RE). Medical treatment was insufficient, for this reason surgical treatment was required. Postoperative evolution was favorable. Conclusion: This pathology should prefer the differential diagnosis of traumatic glaucomas, correlating high clinical suspicion and histological confirmation.
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Vudayana, Dineshkanth, Lakshmi Sativada, Pavani Jerry, and Padmaraju Kolluru. "Clinical Study of Lens Induced Glaucoma at a Tertiary Eye Care Centre." Journal of Evidence Based Medicine and Healthcare 8, no. 10 (March 8, 2021): 537–41. http://dx.doi.org/10.18410/jebmh/2021/105.

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BACKGROUND Lens induced glaucomas are common in India. There were different types of lens induced glaucomas based on clinical features and morphological features. This study was undertaken to evaluate the various characteristics and presentations of glaucomas, to define the risk factors and to evaluate as to how they influence the post-operative visual acuity, intra ocular pressure, inflammation and optic disc changes. METHODS This longitudinal study included 90 cases of lens induced glaucoma admitted in the ophthalmic wards of the Great Eastern Medical School and Hospital, Srikakulam, during the period March 2018 to March 2020. All consecutive patients diagnosed as lens induced glaucoma on the basis of clinical symptoms and signs were included. At presentation, visual acuity, IOP, inflammation including corneal changes were recorded, which were repeated after institution of medical line of treatment and postoperatively patients were followed up regularly at 2, 4 and 6 weeks intervals and the same parameters were evaluated including optic disc changes. RESULTS Occurrence of lens induced glaucoma in the hospital during the study period was 1.72 %. The mean age of presentation of various types of glaucomas was 60.57 years and the female to male ratio was 2:1. The most frequent type of lens induced glaucoma was phacomorphic glaucoma (70 %). In 34.4 % patients best corrected visual acuity was found to be better than 6 / 18. In 14.4 % of cases, visual acuity was found be worse than 6 / 60. In patients who presented with symptoms of less than two weeks duration, better visual acuity of 6 / 12 or more was noted (76.2 %, P < 0.01). In 60 % patients who presented with IOP levels of less than 35 mmHg, better visual acuity of 6 / 12 or more was noted in 76.2 %. The mean IOP noted in patients with symptoms of 2 to 4 weeks duration was found to be 40.33 ± 9.36 mmHg. Inflammation was more severe in patients who were symptomatic for more than 2 weeks (37.50 %, P < 0.05) and also in cases with IOP more than 35 mmHg (40 %). Optic disc of the presented eye was found to be damaged in 35.5 % of cases and in patients presenting with symptoms of more than 2 weeks’ duration it was 62.5 % (P < 0.01). CONCLUSIONS Presentation with intraocular pressure value greater than 35 mm of Hg and with symptoms of more than two weeks would result in severe inflammation further affecting the cornea and causing optic nerve damage which would ultimately jeopardize vision. This can be prevented by early presentation and regular screening of people above 60 years of age. KEYWORDS Lens-Induced, Glaucoma, Cataract
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14

Leffler, Christopher T., Stephen G. Schwartz, Francesca M. Giliberti, Matthew T. Young, and Dennis Bermudez. "What was Glaucoma Called before the 20th Century?" Ophthalmology and Eye Diseases 7 (January 2015): OED.S32004. http://dx.doi.org/10.4137/oed.s32004.

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Glaucoma involves a characteristic optic neuropathy, often with elevated intraocular pressure. Before 1850, poor vision with a normal eye appearance, as occurs in primary open-angle glaucoma, was termed amaurosis, gutta serena, or black cataract. Few observers noted palpable hardness of the eye in amaurosis. On the other hand, angle-closure glaucoma can produce a green or gray pupil, and therefore was called, variously, glaucoma (derived from the Greek for glaucous, a nonspecific term connoting blue, green, or light gray) and viriditate oculi. Angle closure, with palpable hardness of the eye, mydriasis, and anterior prominence of the lens, was described in greater detail in the 18th and 19th centuries. The introduction of the ophthalmoscope in 1850 permitted the visualization of the excavated optic neuropathy in eyes with a normal or with a dilated greenish-gray pupil. Physicians developed a better appreciation of the role of intraocular pressure in both conditions, which became subsumed under the rubric “glaucoma”.
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15

Mokbel, Tharwat H., Mohamed A. Khalaf, Sherief E. El-Khouly, and Nasser O. El-Metwally. "Flexible Ahmed Valve for Selected Cases of Refractory Glaucoma." European Journal of Ophthalmology 22, no. 1 (July 13, 2011): 83–89. http://dx.doi.org/10.5301/ejo.5000003.

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Purpose Glaucoma drainage implants are a useful alternative in treating glaucomas that are resistant to medical therapy and conventional glaucoma filtration surgery. The aim of this study is to evaluate flexible Ahmed glaucoma valve implant for selected cases of refractory glaucoma regarding its efficiency in controlling intraocular pressure (IOP) and possible postoperative complications of its implantation and their management. Method Patients included in this study were selected from patients with uncontrolled IOP by conventional filtration surgery as well as maximum tolerable topical medical treatment when surgery or laser is unlikely to control IOP. For every patient, complete history of age, sex, and history of previous ocular disease was done. Ocular examination for IOP measurement, best-corrected visual acuity measurement, and condition of conjunctiva was done. Ahmed glaucoma valve flexible plate implant (FP7 and FP8) was used. Results The present study included 40 eyes of 40 patients and preoperative IOP ranged from 32 mmHg to 58 mmHg with a mean of 40.36 ± 7.78 mmHg. The postoperative IOP ranged between 14.0 mmHg and 28.0 mmHg with a mean of 18.73 ± 4.8 mmHg. The criteria of success were applied in 37 eyes of 40 eyes (92.5%); they included 30 eyes (81.8%) with absolute success and 7 eyes (18.9%) with partial success. Conclusions Flexible Ahmed glaucoma valve plate implant is a satisfactory method for controlling elevated IOP in cases of refractory glaucoma with success rate of 92.5% and lower incidence of immediate postoperative and implant-related complications.
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Graham, K. L., C. McCowan, and A. White. "Genetic and Biochemical Biomarkers in Canine Glaucoma." Veterinary Pathology 54, no. 2 (September 30, 2016): 194–203. http://dx.doi.org/10.1177/0300985816666611.

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In many health-related fields, there is great interest in the identification of biomarkers that distinguish diseased from healthy individuals. In addition to identifying the diseased state, biomarkers have potential use in predicting disease risk, monitoring disease progression, evaluating treatment efficacy, and informing pathogenesis. This review details the genetic and biochemical markers associated with canine primary glaucoma. While there are numerous molecular markers (biochemical and genetic) associated with glaucoma in dogs, there is no ideal biomarker that allows early diagnosis and/or identification of disease progression. Genetic mutations associated with canine glaucoma include those affecting ADAMTS10, ADAMTS17, Myocilin, Nebulin, COL1A2, RAB22A, and SRBD1. With the exception of Myocilin, there is very limited crossover in genetic biomarkers identified between human and canine glaucomas. Mutations associated with canine glaucoma vary between and within canine breeds, and gene discoveries therefore have limited overall effects as a screening tool in the general canine population. Biochemical markers of glaucoma include indicators of inflammation, oxidative stress, serum autoantibodies, matrix metalloproteinases, tumor necrosis factor–α, and transforming growth factor–β. These markers include those that indicate an adaptive or protective response, as well as those that reflect the damage arising from oxidative stress.
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Jónsson, Davíð Þór, Ólöf Birna Ólafsdóttir, and María Soffía Gottfreðsdóttir. "Visual field loss in eyes undergoing minimally invasive glaucoma surgery in Iceland." Læknablaðið 108, no. 12 (December 7, 2022): 547–51. http://dx.doi.org/10.17992/lbl.2022.12.720.

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INTRODUCTION: Glaucoma is a degenerative disease of the optic nerve and is marked by visual field defects (VFD). The only approved treatment is IOP lowering, either with eye drops, laser or surgery. Minimally invasive glaucoma surgery (MIGS) has become an appealing treatment modality, offering IOP lowering effect without the complication rates of trabeculectomy or the patient adherence required for pharmacologic therapy. In this study we aim to describe the severity of VFD in patients undergoing their first MIGS surgery. METHODS: Retrospective study reviewing the medical records of all patients that underwent MIGS surgery at the University Hospital of Iceland from January 2019 to June 2020. Eyes with previous glaucoma surgeries and secondary glaucomas were excluded. The results were divided into two groups, MIGS with phacoemulsification and standalone MIGS. RESULTS: 112 eyes included in the study. Mean age 74.5 ± 10.6 years. The mean defect (MD) score was 8.8 ± 6.4 and the number of glaucoma medications 1.8 ± 1.0 for the group as a whole. Significant difference (p<0.01) was between the age, MD score and the number of glaucoma medications between the two groups. Looking at the eyes that did not undergo phacoemulsification a significant difference (p<0.05) was between the MD score of primary open angle glaucoma eyes, 11.2 ± 6.5 dB and pseudoexfoliation glaucoma, 6.0 ± 3.3 dB. CONCLUSION: Visual field defect and the number of glaucoma medications at referral to surgery was markedly less compared to a trabeculectomy study done in Iceland 3 years prior. Few comparable studies include MD score in their results, most focus on changes in intraocular pressure. Comparing the MD score to three studies from Germany and Austria the MD score seems to be similar. In our study a lower MD score for pseudoexfoliation glaucoma implies that Icelandic ophthalmologists send pseudoexfoliation eyes earlier for an operation.
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Kusumawardhany, Rini, Rani Dwi Indriyani, and Raynaldo Aryesta Oka Prastica. "implementation of community services of glaucoma counseling in Citra Medika Hospital of Sidoarjo." Surabaya Medical Journal 1, no. 1 (May 20, 2023): 62–65. http://dx.doi.org/10.59747/smjidisurabaya.v1i1.11.

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Background: Glaucoma is a disease attributed to damage to the optic nerve, resulting in decreased visual field and vision function. Glaucoma's main risk factor is the increment of intraocular pressure due to an imbalance of aqueous humor production and secretion. If this condition goes untreated, it will lead to retinal ganglion cell degeneration. These cells are part of the central nervous system, which has cell bodies in the retinal layer and axons in the optic nerve. These cells' degeneration causes cupping, which is the appearance of the optic disc and vision loss. Glaucoma's cause has yet to be identified, and not all factors that cause its progression have been found. Objectives: this community dedication was written to access the society knowledge about glaucoma. Methods: This project entailed counseling the community around Citra Medika Hospital, Sidoarjo. This community service was conducted by co-assistant members of the Faculty of Medicing, Hang Tuah University, Surabaya. It aimed to provide participants with an understanding of glaucoma, including its types, risk factors, and preventive measures. Discussion: The participants in this community outreach were the individuals waiting for their relatives at the eye outpatient installation at Citra Medika Hospital, Sidoarjo. In total, 30% of the participants were male and 70% were female. Conclusion: This community service is expected to increase public awareness of glaucoma. As a result, they may then carry out examinations when they encounter glaucoma-related symptoms.
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Ravinet, E., A. Mermoud, and R. Brignoli. "Four Years Later: A Clinical Update on Latanoprost." European Journal of Ophthalmology 13, no. 2 (March 2003): 162–75. http://dx.doi.org/10.1177/112067210301300208.

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Purpose Almost five years have elapsed since the introduction of latanoprost on several markets and considering the large number of publications dealing with it, the authors felt that it was worth re-evaluating the drug. Methods The criterion used to select trials for inclusion in the review was: all articles mentioning the drug in common electronic data-bases; these were then screened and considered, on the basis of methodological quality. Results Experimental data suggest that latanoprost acts by remodeling the extracellular matrix in the ciliary muscle, thus increasing the flow of aqueous humor through the ciliary muscle bundles of the uveoscleral pathway. POAG Latanoprost persistently improves the pulsatile ocular blood flow in primary open angle glaucoma (POAG). Recent trials confirmed the greater IOP-lowering efficacy of latanoprost vs. timolol, dorzolamide, brimonidine and unoprostone. Trials lasting up to 24 months showed that latanoprost is effective in long-term treatment of POAG and ocular hypertension (OH), with no signs of loss of efficacy when compared to timolol or dorzolamide. Latanoprost provides better control of circadian IOP. Non-responders to b-blockers should preferably be switched to latanoprost monotherapy before a combination therapy is started. The possibility of a fixed combination of latanoprost and timolol has been explored, with promising results. NTG Latanoprost is effective in normal tension glaucoma (NTG), lowering IOP, improving pulsatile ocular blood flow and increasing ocular perfusion pressure. Other Glaucomas Latanoprost may provide effective IOP control in angle-closure glaucoma after iridectomy, in pigmentary glaucoma, glaucoma after cataract extraction and steroid-induced glaucoma. However, latanoprost was effective in only a minority of pediatric cases of glaucoma and is contraindicated in all forms of uveitic glaucoma. Safety In the articles reviewed, new or duration-related adverse events were reported.
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Vladyka, Vilibald, R. Lis˘c˘ák, G. S˘imonová, J. Pilbauer, I. Hejduková, and L. Novác˘ek. "Progress in glaucoma treatment research: a nonrandomized prospective study of 102 patients with advanced refractory glaucoma treated by Leksell gamma knife irradiation." Journal of Neurosurgery 102, Special_Supplement (January 2005): 214–19. http://dx.doi.org/10.3171/sup.2005.102.s_supplement.0214.

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Object. The authors performed a study to characterize the effects of ciliary body gamma knife surgery (GKS) for advanced glaucoma. Methods. In addition to a pilot project involving 14 patients, 88 other patients were treated. Four 8-mm isocenters were used. Blind eyes received 20 Gy to the 50% isodose. If there was preserved vision the dose was 15 Gy. The median follow up was 20 months (range 2–54 months). Severe pain was present in 93% of patients with secondary glaucoma; after GKS it was substantially improved in 89% of cases. In primary open angle glaucoma, the pain was less frequent and severe. In more than half the patients it disappeared during a median latency of 6 weeks. The median intraocular pressure value was lowered in patients with secondary glaucoma (from 51.3–27 mm Hg). The same values for primary glaucoma were 25.3 and 16.1 mm Hg, respectively, after a median latency of 12 weeks. Twenty-seven of 40 patients with neovascular glaucoma showed a marked reduction of neovascularization after a median latency of 18 weeks. Treatment complications were slight. There was postoperative lacrimation in 61%. Two patients underwent postirradiation cataract extraction. Noninfectious keratitis was observed in two patients. Pharmacotherapy could be reduced in all patients and ceased in approximately one third. There has been no recurrence of the initial symptoms and no worsening of visual acuity. Conclusions. Gamma knife surgery ameliorates the main symptoms in advanced glaucomas and precludes the need for eventual ocular enucleation.
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21

Turkoski, Beatrice B. "Glaucoma and Glaucoma Medications." Orthopaedic Nursing 19, no. 5 (September 2000): 71–76. http://dx.doi.org/10.1097/00006416-200019050-00012.

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Turkoski, Beatrice B. "Glaucoma and Glaucoma Medications." Orthopaedic Nursing 31, no. 1 (2012): 37–41. http://dx.doi.org/10.1097/nor.0b013e31824196a8.

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&NA;. "Glaucoma and Glaucoma Medications." Orthopaedic Nursing 31, no. 1 (2012): 42–43. http://dx.doi.org/10.1097/nor.0b013e3182454dfe.

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H. Mokbel, Tharwat, Asaad A. Ghanem, Ashraf I. Moawad, and Ihab M. NafieMD. "Deep sclerectomy in exfoliative glaucoma and open-angle glaucoma." Oftalmologicheskii Zhurnal 23, no. 1 (February 5, 2010): 95–101. http://dx.doi.org/10.31288/oftalmolzh2010195101.

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25

Vladyka, Vilibald, R. Lis˘c˘ák, G. S˘imonová, J. Pilbauer, I. Hejduková, and L. Novác˘ek. "Progress in glaucoma treatment research: a nonrandomized prospective study of 102 patients with advanced refractory glaucoma treated by Leksell gamma knife irradiation." Journal of Neurosurgery 102 (January 2005): 214–19. http://dx.doi.org/10.3171/jns.2005.102.s_supplement.0214.

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Object.The authors performed a study to characterize the effects of ciliary body gamma knife surgery (GKS) for advanced glaucoma.Methods.In addition to a pilot project involving 14 patients, 88 other patients were treated. Four 8-mm isocenters were used. Blind eyes received 20 Gy to the 50% isodose. If there was preserved vision the dose was 15 Gy. The median follow up was 20 months (range 2–54 months).Severe pain was present in 93% of patients with secondary glaucoma; after GKS it was substantially improved in 89% of cases. In primary open angle glaucoma, the pain was less frequent and severe. In more than half the patients it disappeared during a median latency of 6 weeks. The median intraocular pressure value was lowered in patients with secondary glaucoma (from 51.3–27 mm Hg). The same values for primary glaucoma were 25.3 and 16.1 mm Hg, respectively, after a median latency of 12 weeks. Twenty-seven of 40 patients with neovascular glaucoma showed a marked reduction of neovascularization after a median latency of 18 weeks. Treatment complications were slight. There was postoperative lacrimation in 61%. Two patients underwent postirradiation cataract extraction. Noninfectious keratitis was observed in two patients. Pharmacotherapy could be reduced in all patients and ceased in approximately one third. There has been no recurrence of the initial symptoms and no worsening of visual acuity.Conclusions.Gamma knife surgery ameliorates the main symptoms in advanced glaucomas and precludes the need for eventual ocular enucleation.
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Almazroa, Ahmed, Sami Alodhayb, Kaamran Raahemifar, and Vasudevan Lakshminarayanan. "An Automatic Image Processing System for Glaucoma Screening." International Journal of Biomedical Imaging 2017 (2017): 1–19. http://dx.doi.org/10.1155/2017/4826385.

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Horizontal and vertical cup to disc ratios are the most crucial parameters used clinically to detect glaucoma or monitor its progress and are manually evaluated from retinal fundus images of the optic nerve head. Due to the rarity of the glaucoma experts as well as the increasing in glaucoma’s population, an automatically calculated horizontal and vertical cup to disc ratios (HCDR and VCDR, resp.) can be useful for glaucoma screening. We report on two algorithms to calculate the HCDR and VCDR. In the algorithms, level set and inpainting techniques were developed for segmenting the disc, while thresholding using Type-II fuzzy approach was developed for segmenting the cup. The results from the algorithms were verified using the manual markings of images from a dataset of glaucomatous images (retinal fundus images for glaucoma analysis (RIGA dataset)) by six ophthalmologists. The algorithm’s accuracy for HCDR and VCDR combined was 74.2%. Only the accuracy of manual markings by one ophthalmologist was higher than the algorithm’s accuracy. The algorithm’s best agreement was with markings by ophthalmologist number 1 in 230 images (41.8%) of the total tested images.
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Fallano, Katherine, Igor Bussel, Larry Kagemann, Kira L. Lathrop, and Nils A. Loewen. "Training strategies and outcomes of ab interno trabeculectomy with the trabectome." F1000Research 6 (January 23, 2017): 67. http://dx.doi.org/10.12688/f1000research.10236.1.

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Plasma-mediated ab interno trabeculectomy with the trabectome was first approved by the US Food and Drug Administration in 2004 for use in adult and pediatric glaucomas. Since then, increased clinical experience and updated outcome data have led to its expanded use, including a range of glaucomas and angle presentations, previously deemed to be relatively contraindicated. The main benefits are a high degree of safety, ease, and speed compared to traditional filtering surgery and tube shunts. The increasing burden of glaucoma and expanding life expectancy has resulted in demand for well-trained surgeons. In this article, we discuss the results of trabectome surgery in standard and nonstandard indications. We present training strategies of the surgical technique that include a pig eye model, and visualization exercises that can be performed before and at the conclusion of standard cataract surgery in patients who do not have glaucoma. We detail the mechanism of enhancing the conventional outflow pathway and describe methods of visualization and function testing.
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Fallano, Katherine, Igor Bussel, Larry Kagemann, Kira L. Lathrop, and Nils A. Loewen. "Training strategies and outcomes of ab interno trabeculectomy with the trabectome." F1000Research 6 (May 2, 2017): 67. http://dx.doi.org/10.12688/f1000research.10236.2.

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Plasma-mediated ab interno trabeculectomy with the trabectome was first approved by the US Food and Drug Administration in 2004 for use in adult and pediatric glaucomas. Since then, increased clinical experience and updated outcome data have led to its expanded use, including a range of glaucomas and angle presentations, previously deemed to be relatively contraindicated. The main benefits are a high degree of safety, ease, and speed compared to traditional filtering surgery and tube shunts. The increasing burden of glaucoma and expanding life expectancy has resulted in demand for well-trained surgeons. In this article, we discuss the results of trabectome surgery in standard and nonstandard indications. We present training strategies of the surgical technique that include a pig eye model, and visualization exercises that can be performed before and at the conclusion of standard cataract surgery in patients who do not have glaucoma. We detail the mechanism of enhancing the conventional outflow pathway and describe methods of visualization and function testing.
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Khan, Sikander Hayat. "CONGENITAL GLAUCOMA." Professional Medical Journal 25, no. 08 (August 9, 2018): 1203–6. http://dx.doi.org/10.29309/tpmj/18.4581.

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Hurtado Sarrio, Mercedes. "Dealing with glaucoma." Edorium Journal of Ophthalmology 3, no. 2 (June 3, 2019): 1–4. http://dx.doi.org/10.5348/100003o02ms2019ed.

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31

San Laureano, Joseph. "When is glaucoma really glaucoma?" Clinical and Experimental Optometry 90, no. 5 (September 2007): 376–85. http://dx.doi.org/10.1111/j.1444-0938.2007.00175.x.

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Fan, Ning, Junkai Tan, and Xuyang Liu. "Is “normal tension glaucoma” glaucoma?" Medical Hypotheses 133 (December 2019): 109405. http://dx.doi.org/10.1016/j.mehy.2019.109405.

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Carrizosa Murcia, Marcelo, and Vivian Alexandra Gutiérrez Carranza. "Genética del glaucoma primario de ángulo abierto." Ciencia & Tecnología para la Salud Visual y Ocular 14, no. 1 (June 10, 2016): 107. http://dx.doi.org/10.19052/sv.3634.

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<p align="justify"><em>Objetivo</em>: conocer la genética del glaucoma primario de ángulo abierto para la identificación de genes que permitan establecer una herramienta de diagnóstico temprano para un mejor manejo de la enfermedad. <em>Materiales y métodos</em>: se realizó una búsqueda sistematizada de literatura primaria en bases de datos como PubMed, SciELO y Elsevier; además, se utilizaron referentes de varios textos para algunas terminologías, cuadros y tablas de los diferentes glaucomas, para determinar las características, el diagnóstico diferencial y la identificación de los genes asociados con el desarrollo del glaucoma primario de ángulo abierto. La información seleccionada corresponde al periodo 2010-2015. <em>Conclusiones</em>: el glaucoma primario de ángulo abierto es una enfermedad que depende, en la mayoría de casos, de un patrón de herencia dominante, caracterizado principalmente por dos genes: el miocilina (MYOC) y el optineurina (OPTN); esto da lugar a seis locus identificados para esta enfermedad. También está relacionado con otras patologías que son factores de riesgo para desarrollar glaucoma, como la miopía alta, la diabetes mellitus, la hipertensión arterial, la etnia, entre otras manifestaciones sistémicas. De igual manera, es importante recordar que afecta la calidad de vida y que es un problema de salud pública.</p>
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Medvedovskaya, Nataliia, and Zoriana Povch. "Risk Factors for Development of Glaucoma in the Practice of Family Doctor." Family Medicine, no. 5 (December 30, 2016): 52–54. http://dx.doi.org/10.30841/2307-5112.5.2016.248660.

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The objective: studying of risk factors of developing of glaucoma for formation of risk groups in daily practice of the family doctor, in particular timely identification of an ocular hypertension, the prevention of establishment for the first time of the diagnosis in her late stage became a research objective. Patients and methods. Outpatient and polyclinic offices of five healthcare institutions of the city of Kiev in which primary help by the principles of the general medical practice – family medicine is given became scientific base of a research. Forms of account № 12 «The report on the diseases registered at patients who live in the area of service of treatment and prevention facility» and questionnaires of a sociological research of risk factors of glaucoma (820 questionnaires) were primary material. Achievement of goals of a research demanded use of a complex of methods of a research, a basis for which was a system approach, namely: bibliosemantic, sociological (questionnaire), medico-statistical methods. Results. Оf a research it is proved that relevance of a problem of the prevention of a blindness and a low vision owing to glaucoma increases in Ukraine over the years. Modern risk factors of development of glaucoma which have the proved influence on formation of an ocular hypertension, and are studied later and glaucomas, knowledge of which will help physicians of primary contact with the patient to form actively risk groups on glaucoma that, in turn, allows to individualize at the same time preventively – improving, medical and diagnostic medical care in each case and to objectify assessment of its results in dynamics. Conclusion. Knowledge the doctor of the general practice the family doctor of modern risk factors of development of glaucoma is necessary for her effective prevention as it is proved that timely diagnosis of a disease (at an early stage) does possible correction of the existing risk factors of emergence and progressing of glaucoma that is very important in daily practice of the doctor of the general practice – the family doctor.
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LIBBY, RICHARD T., MICHAEL G. ANDERSON, IOK-HOU PANG, ZACHARY H. ROBINSON, OLGA V. SAVINOVA, I. MIHAI COSMA, AMY SNOW, et al. "Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration." Visual Neuroscience 22, no. 5 (September 2005): 637–48. http://dx.doi.org/10.1017/s0952523805225130.

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The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly. Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases. We previously reported inherited, age-related progressive glaucoma in DBA/2J mice. Here, we report our updated findings from studying the disease in a large number of DBA/2J mice. The period when mice have elevated IOP extends from 6 months to 16 months, with 8–9 months representing an important transition to high IOP for many mice. Optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age. This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy.
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Temblador-Barba, Irene, Antonio Espejo-González, Juan de Dios López-Pozo, María Martínez-Jiménez, and Javier Benítez-del-Castillo. "Ghost cell glaucoma." ACTUALIDAD MEDICA 104, no. 806 (April 30, 2019): 46–47. http://dx.doi.org/10.15568/am.2019.806.cc01.

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37

De La Rosa, M. Gonzalez, M. Gonzalez-Hernandez, V. Lozano Lopez, and D. Perera Sanz. "Topographic Spatial Summation in Glaucoma." European Journal of Ophthalmology 17, no. 4 (July 2007): 538–44. http://dx.doi.org/10.1177/112067210701700410.

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Purpose Stimulus luminance (L) and area (A) are related by the equation LxAk=constant. The authors evaluated the k value at 66 positions of the central visual field in patients with glaucoma, to modify L and A simultaneously in order to examine advanced glaucomas with a bigger dynamic range. Methods The luminance limitation of a computer screen with automatic photometric control was compensated for by increasing the stimulus area in the range between 0 and 17 dB, using the k topographic values previously calculated on normal subjects. Four initial series of 21, 12, 10, and 10 glaucomas were sequentially examined with the Octopus 311 in which the stimulus size cannot be freely changed during the examination, and with the experimental method (Pulsar-SAP) modifying stimulus sizes to equal the results. k Final estimation was verified in 60 new cases. Results k Values increase progressively with defect deepness. Values higher than those of the normal population with equivalent topographic differences were obtained. Correlation between indices was as follows: MD: r=0.94 (p<0.0001); square root of the loss of variance (sLV): r=0.93 (p<0.0001). Frequency of local defects was similar in both procedures. Average topographic differences between thresholds were usually less than 1 dB. The average threshold difference favored Pulsar-SAP by 0.45 dB at those points where the average threshold of both examinations was less than 18 dB and 0.37 dB where such average was higher than or equal to 18 dB. Conclusions k Value is higher in patients with glaucoma than in normal subjects, although the topographic features are similar. It is feasible to design a scale combining stimulus luminance and sizes to use screens with relative low brightness as surfaces for visual field examination.
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Rascheskov, A. Yu, I. A. Loskoutov, and A. V. Korneeva. "Ahmed glaucoma valve implantation in glaucoma surgery." National Journal glaucoma 23, no. 1 (April 26, 2024): 96–111. http://dx.doi.org/10.53432/2078-4104-2024-23-1-96-111.

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Glaucoma is the leading cause of irreversible blindness worldwide. Despite the large variety of treatment methods used in glaucoma, most researchers believe that surgery is the most effective way to normalize the level of intraocular pressure and preserve visual functions. Trabeculectomy and glaucoma drainage implantation are the most commonly performed glaucoma surgeries. Although trabeculectomy is the gold standard, at present time there is an uptrend in the use of glaucoma drainage devices. Ahmed glaucoma valve (AGV) is one of the most widely used glaucoma drainage devices in the world. This review of literature presents contemporary results of AGV implantation, possible complications and ways of optimizing that technique.
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Tuck, Maurice W., and Ronald P. Crick. "Glaucoma." Disease Management and Health Outcomes 4, no. 4 (1998): 183–92. http://dx.doi.org/10.2165/00115677-199804040-00001.

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Kang, Jessica Minjy, and Angelo P. Tanna. "Glaucoma." Medical Clinics of North America 105, no. 3 (May 2021): 493–510. http://dx.doi.org/10.1016/j.mcna.2021.01.004.

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41

Betchkal, Janet. "Glaucoma." Ophthalmic Surgery, Lasers and Imaging Retina 19, no. 1 (January 1988): 68–69. http://dx.doi.org/10.3928/1542-8877-19880101-23.

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42

Davis, Abigail, and Michael James Gilhooley. "Glaucoma." InnovAiT: Education and inspiration for general practice 10, no. 6 (May 6, 2016): 346–52. http://dx.doi.org/10.1177/1755738016638863.

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43

Pederson, Jonathan E. "Glaucoma." Postgraduate Medicine 90, no. 7 (November 15, 1991): 41–48. http://dx.doi.org/10.1080/00325481.1991.11701121.

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Jordanova, Elena, Paraskeva Senćanić-Hentova, Ivan Marjanović, Ivan Senćanić, Ivana Stefanović, Tanja Pavlović, and Marko Baralić. "Glaucoma." Naucni casopis urgentne medicine - Halo 194 24, no. 3 (2018): 189–209. http://dx.doi.org/10.5937/halo1803189j.

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45

King, A., A. Azuara-Blanco, and A. Tuulonen. "Glaucoma." BMJ 346, jun11 1 (June 11, 2013): f3518. http://dx.doi.org/10.1136/bmj.f3518.

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46

Heijl, Anders. "Glaucoma." Acta Ophthalmologica Scandinavica 73, no. 3 (May 27, 2009): 193–94. http://dx.doi.org/10.1111/j.1600-0420.1995.tb00267.x.

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47

Laios, Konstantinos, Marilita M. Moschos, and George Androutsos. "Glaucoma." Journal of Glaucoma 26, no. 6 (June 2017): e198-e199. http://dx.doi.org/10.1097/ijg.0000000000000468.

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48

Krieglstein, Gunter K. "Glaucoma." Current Opinion in Ophthalmology 1, no. 2 (April 1990): 103–4. http://dx.doi.org/10.1097/00055735-199001020-00001.

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&NA;. "Glaucoma." Current Opinion in Ophthalmology 1, no. 2 (April 1990): 191–98. http://dx.doi.org/10.1097/00055735-199001020-00020.

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Krieglstein, Gunter K. "Glaucoma." Current Opinion in Ophthalmology 1, no. 2 (April 1990): 103–4. http://dx.doi.org/10.1097/00055735-199004000-00001.

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