Dissertations / Theses on the topic 'Glander'
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Glander, Tassilo [Verfasser], and Jürgen [Akademischer Betreuer] Döllner. "Multi-scale representations of virtual 3D city models / Tassilo Glander. Betreuer: Jürgen Döllner." Potsdam : Universitätsbibliothek der Universität Potsdam, 2013. http://d-nb.info/1032046686/34.
Full textGlander, Shirin [Verfasser], and Juliette de [Akademischer Betreuer] Meaux. "Is the immune system required to adapt to flowering time change? / Shirin Glander ; Betreuer: Juliette de Meaux." Münster : Universitäts- und Landesbibliothek Münster, 2015. http://d-nb.info/1137705361/34.
Full textZarzour, Amin [Verfasser], Klaus-Michael Akademischer Betreuer] Taube, Hans-Jürgen [Akademischer Betreuer] Glander, Johannes [Akademischer Betreuer] [Schubert, and Wolfgang [Akademischer Betreuer] Marsch. "Diagnostisches Vorgehen bei Mundschleimhauterkrankungen / Amin Zarzour. Betreuer: Klaus-Michael Taube ; Hans-Jürgen Glander ; Johannes Schubert ; Wolfgang Marsch." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2010. http://d-nb.info/1025056035/34.
Full textRößner, Claudia [Verfasser], Uwe [Akademischer Betreuer] Paasch, Sonja [Akademischer Betreuer] Grunewald, Hans-Jürgen [Gutachter] Glander, and Manfred [Gutachter] Wirth. "Transduktion von Apoptosesignalen ejakulierter Spermatozoen von Diabetikern / Claudia Rößner ; Gutachter: Hans-Jürgen Glander, Manfred Wirth ; Uwe Paasch, Sonja Grunewald." Leipzig : Universitätsbibliothek Leipzig, 2014. http://d-nb.info/1238600034/34.
Full textMöbius, Anne [Verfasser], Uwe [Akademischer Betreuer] Paasch, and Hans-Jürgen [Gutachter] Glander. "Wirkung fraktional ablativer Lasersysteme in der Therapie der gealterten und chronisch lichtgeschädigten Haut / Anne Möbius ; Gutachter: Hans-Jürgen Glander ; Betreuer: Uwe Paasch." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/1238527833/34.
Full textKriegel, Christian [Verfasser], Uwe [Akademischer Betreuer] Paasch, Hans-Jürgen [Gutachter] Glander, and Jens-Uwe [Gutachter] Stolzenburg. "Untersuchungen zur kapazitationsassoziierten Signaltransduktion in humanen Spermatozoen und Evaluation des MACS-Verfahrens zur Ejakulataufbereitung / Christian Kriegel ; Gutachter: Hans-Jürgen Glander, Jens-Uwe Stolzenburg ; Betreuer: Uwe Paasch." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/1238367070/34.
Full textKratzsch, Dorothea Sophia [Verfasser], Uwe [Akademischer Betreuer] Paasch, Hans-Jürgen [Gutachter] Glander, and Matthias [Gutachter] Blüher. "Adipositas ist mit verminderter Spermienqualität und veränderten Konzentrationen an Adipokinen in Serum und Seminalplasma assoziiert / Dorothea Sophia Kratzsch ; Gutachter: Hans-Jürgen Glander, Matthias Blüher ; Betreuer: Uwe Paasch." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/1238242243/34.
Full textSILVA, Cecilia Maria de Souza Leão e. "Avaliação da reação em cadeia de polimerase (PCR) e elisa indireto como método de diagnóstico da Burkholderia mallei (Mormo)." Universidade Federal Rural de Pernambuco, 2014. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5041.
Full textMade available in DSpace on 2016-07-19T14:08:54Z (GMT). No. of bitstreams: 1 Cecilia Maria de Souza Leao e Silva.pdf: 1235721 bytes, checksum: fa10ebf32171212966df2a23383f5075 (MD5) Previous issue date: 2014-02-21
Glanders is a highly contagious disease caused by Burkholderia mallei solipeds, a Gram - negative bacterium, not motility and aerobic coccobacillus, primarily infecting horses, donkeys and mules, though humans are considered accidental hosts . The Burkholderia mallei is listed in the list of the World Organisation for Animal Health (OIE) as an important public health disease, and due to its high potential for infection is referred to as a bioterrorism agent. According to the OIE comprises the serological diagnosis, allergy testing and bacterial isolation, and complement fixation, the official test to be performed for trade of animals. This method of diagnosis is recommended in Brazil by Normative Instruction Nº 24 Ministry of Agriculture, Livestock and Food Supply by its high sensitivity and specificity. Serological qPCR showed 76 (16.7%) positivity and a sensitivity of 24.7% and a specificity of 89 % when compared to the gold standard western blotting used. The results show that the use of the qPCR may be used as a complementary technique to other methods for rapid and accurate identification of Burkholderia mallei. About statistical results showed that the ELISAi showed the highest sensitivity (35.5%) and specificity (97.6 %) when compared to western blotting. The results show the importance of preparation and use of antigens that are produced with local strains, resulting in higher sensitivity and specificity of the test.
O Mormo constitui-se em uma doença altamente contagiosa dos solípedes causada pela Burkholderia mallei, uma bactéria Gram-negativa, não móvel e cocobacilo aeróbio, infectando primariamente cavalos, burros e mulas, entretanto humanos são considerados hospedeiros acidentais. A Burkholderia mallei está relacionada na lista de doenças da Organização Mundial para a Saúde Animal (OIE) como doença de importância de saúde pública, e devido ao seu alto potencial de infecção é referenciada como agente de bioterrorismo. De acordo com a OIE o diagnóstico compreende o teste sorológico, alérgico e o isolamento bacteriano, sendo a fixação do complemento, o teste oficial a ser realizado para trânsito de animais. Este método de diagnóstico está preconizado no Brasil pela Instrução Normativa Nº 24 do Ministério da Agricultura Pecuária e Abastecimento por apresentar alta sensibilidade e especificidade. A qPCR sorológica apresentou 76 (16,7%) positividade e uma sensibilidade de 24,7% e especifidade de 89% quando comparado ao western blotting padrão ouro utilizado.. Os resultados mostram que a utilização da qPCR pode ser utilizada como técnica complementar de outras metodologias para identificação rápida e precisa da Burkholderia mallei. Em relação aos testes sorológicos, os resultados estatísticos mostraram que o ELISAi apresentou a maior sensibilidade (35,5%) e especificidade (97,6%) quando comparado ao western blotting. Os resultados mostram a necessidade da preparação e utilização de antígenos que sejam produzidos com cepas locais, determinando maior sensibilidade e especificidade ao teste.
Bret-Dibat, Christine. "Porocarcinome eccrine : difficultés diagnostiques et thérapeutiques." Bordeaux 2, 1996. http://www.theses.fr/1996BOR23002.
Full textBrunelle, Philippe. "Contribution à l'exploration thyroïdienne et parathyroidïenne : méthodes et applications physio-pathologiques." Rouen, 1986. http://www.theses.fr/1986ROUE04NR.
Full textCandoni, Philippe. "Ectopies salivaires vraies : à propos de 5 observations et d'une revue de la littérature." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M129.
Full textSarzier-Lago, Sylvie. "Les syringomes." Montpellier 1, 1995. http://www.theses.fr/1995MON11093.
Full textBottin-Menzer, Christine. "A propos d'un cas de néoplasme de glande péri-anale : analogie avec les glandes hépatoïdes du chien." Université Louis Pasteur (Strasbourg) (1971-2008), 1985. http://www.theses.fr/1985STR1M045.
Full textSagulin, Gun-Britt. "Effects of calcium and calciotropic hormones on salivary gland function." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1989. http://catalog.hathitrust.org/api/volumes/oclc/20620549.html.
Full textAmet, Yolande. "Stéroi͏̈des sexuels et glandes à sécrétion externe de la peau : Interactions stéroi͏̈des-récepteurs et répercussions physiologiques." Brest, 1986. http://www.theses.fr/1986BRES2019.
Full textFerraris, Corinne. "Pluripotentialité des kératinocytes épidermiques et cornéens chez les mammifères." Grenoble 1, 1994. http://www.theses.fr/1994GRE10090.
Full textPiéchaud, Bernadette. "Parotidites suppurées néonatales : à propos de trois observations à staphylocoque doré." Bordeaux 2, 1989. http://www.theses.fr/1989BOR25046.
Full textFloch-Quintin, Josiane. "La glande uropygienne de la caille : modèle pour l'étude du métabolisme et de la toxicite loco-régionale de stéroïdes hormonaux." Brest, 1988. http://www.theses.fr/1988BRES2024.
Full textVan, Wyk Elizabeth Joy. "Pineal-adrenal gland interactions in search of an anti-stressogenic role for melatonin." Thesis, Rhodes University, 1993. http://hdl.handle.net/10962/d1004115.
Full textCastelli, Joël. "Radiothérapie adaptative morphologique et métabolique des cancers ORL." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B043/document.
Full textObjectifs: The aims of this work were (i) to evaluate the dosimetric benefit and to predict the clinical benefit of adaptive radiotherapy for head and neck cancer, regarding both toxicities and local control, (ii) to identify patients whose good candidate for an adaptive strategy, and (iii) to identify the best adaptive strategy to spare the parotid glands. Materials and methods: The dosimetric benefit was assessed using data from a phase III study evaluating the clinical benefit of an adaptive radiotherapy. Cumulated dose with and without adaptive was estimated using deformable image registration. Different methods of deformable image registration were evaluated regarding both spatial and dose estimation accuracy. Predictive model of the risk of parotid gland overdose was computed using generalized linear mixed model and cross validation by leave‐one‐out. The dosimetric benefit of numerous replanning strategies, defined by various numbers and timing of replanning, with regard to parotid gland sparing, was quantified. We performed a systematic review to evaluate the predictive value of quantitative PET parameters. The predictive value of PET intensity parameters was assessed using two independent cohorts of patients. Résultats: Without adaptive radiotherapy, 65% of the patients had a PG overdose of more than 2 Gy and 50% of the patients had a tumor underdose of more than 1 Gy. Adaptive radiotherapy allows to correct both parotid gland overdose and tumor underdose. Based on parameters calculated at the planning and at the first week of treatment, predictive models of PG overdose and tumor underdose were computed. PET parameters correlated with overall survival were identified. Using two independent cohorts of patients, a nomogram to predict survival was build and externally validated. Conclusion: Our studies showed the benefit of adaptive radiotherapy to spare the parotid glands while increasing tumor coverage. These benefits should allow to decrease the toxicities while increasing local control. Early anatomical and dosimetric parameters allow identifying patients at risk of tumor underdose or parotid gland overdose. PET performed before the treatment allows identifying patients with a high‐risk of locoregional failure and death, potentially candidates for treatment. These results justify further studies on a larger cohort of patients, ideally in phase III clinical trials
Dallal, Nadeem D. McArthur Carole. "An investigation of HIV in Cameroon exploring the link between risk-taking behavior, salivary hormones and AIDS; and delineating the effect of HIV-1-TAT on human salivary gland cells in an in vitro model of diffuse infiltrative lymphocytosis syndrome /." Diss., UMK access, 2004.
Find full text"A thesis in oral biology." Typescript. Advisor: Carole McArthur. Vita. Title from "catalog record" of the print edition Description based on contents viewed Feb. 23, 2006. Includes bibliographical references (leaves 83-91 ). Online version of the print edition.
Newey, Paul J. "The role of the tumour suppressor proteins, parafibromin and menin, in endocrine tumourigenesis." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711613.
Full textHue-Beauvais, Catherine. "Périodes critiques pour la croissance et le développement mammaire lors d’une alimentation obésogène chez la lapine et la souris : implication de la leptine." Thesis, Versailles-St Quentin en Yvelines, 2014. http://www.theses.fr/2014VERS0027/document.
Full textWomen’s nutrition can have long-term effects on mammary development and on the development and the health of the offspring. Leptin may play a major role during these processes. In the present work we show that leptin synthesis in the mammary gland slightly increases during pregnancy, but largely increases during lactation. We also show that, in the rabbit, milk consumption from obesogenic-fed dams promote the later effects of an obesogenic diet and leads to an abnormal mammary development observed in the offspring. We also highlight the synthesis and the mammary secretion of leptin in a heterologous cellular model. We also evaluate the intra-species variability as well as the growth considering two nutritional windows: obesogenic feeding from the puberty or from the birth, in two lineages of mice, FVB/N and C57BL /6.This work shows that the consumption of altered maternal milk has long-term effects by influencing the growth and the mammary development of the offspring, in rabbit
Sacco, Sonia. "Rôle de la signalisation Rspondin dans le développement et l’homéostasie de la glande surrénale." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4125/document.
Full textThe adrenal gland is an endocrine organ of vital importance because of its role in the maintenance of body homeostasis. To ensure this function, the adrenal cortex is divided into different areas that produce specific hormones. The mechanisms of the establishment of this zonation at the embryonic level as well as its maintenance throughout life are still unknown today. The Rspo1 and 3 genes are expressed very specifically at the capsule level but they encode secreted proteins that act on the adjacent cells of the zona glomerulosa in order to induce the activation of the Wnt / β-catenin canonical pathway. The deletion of the Rspo3 gene during embryonic development leads to a lack of activation of the Shh and Wnt / β-catenin pathways and hence a lack of zonation. Its function is also essential during adult life since it ensures both the maintenance of tissue homeostasis and the glomerular zone. The absence of the Rspo1 gene does not affect development, zonation or homeostasis of the adrenal gland. On the other hand, its ectopical expression in all the adrenal cortex leads to an abnormal activation of the Wnt / β-catenin pathway in this area and thus to an hyperplasia of the adrenal glands. From 1 year of age, this adrenal hyperplasia leads to the formation of tumors. This work demonstrates that the capsule through the Rspondin 3 gene acts as a signaling center capable of controlling both homeostasis by replacing damaged cells and maintaining the zonation of the adrenal gland
Miao, Yu Rebecca. "The role of c-Myb in mammary gland development and tumourigenesis." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/7069.
Full textThe first aim of this study is to examine the expression of c-Myb during normal mammary gland development. The expression of c-Myb is extensively characterised in a temporal and spatial fashion. Nuclear staining of c-Myb by immunohistochemisty was found to be most elaborately expressed in the ductal epithelium during early mammary gland development. Mouse mammary gland lacking c-myb showed disorganised ductal structure in virgin mice, but did not affect subsequent pregnancy and lactation.
To extend the view that c-Myb is involved in mammary tumourigenesis c-myb-transduced immortalised mammary epithelial cells and two mammary tumour prone transgenic mouse models were examined. NMuMG cells transduced with c-myb showed enhanced proliferation and reduced Annexin V staining consistent with the protection from apoptosis. This reduced apoptosis is consistent with, and perhaps contingent upon, the elevated expression observed for bcl-2 and grp78. The data assembled by expression studies raised the possibility that c-Myb is essential for the establishment of mammary gland tumor in both MMTV-Neu and MMTV-PyMT spontaneous mammary gland tumor models. Loss of c-Myb expression in these models significantly delayed and in most instances completely abolished the onset of mammary gland tumours in both models. Preliminary evidence also indicated that Stat3 phosphorylation may underpin the elevated c-Myb expression in mouse mammary tumour cells.
The focus of my thesis then shifted to examining ways to exploit elevated c-Myb target gene GRP78 expression on the cell surface of mammary tumour cells. To do this I employed a GRP78 binding pro-apoptotic chimera peptide that specifically binds to GRP78 where I examined its efficacy against primary and metastatic breast cancer models. My results demonstrated the anti-tumour activity of the GRP78-chimera peptide both in vitro and in vivo. More importantly, the peptide is also effective at prolonging disease-free survival in mice with established metastatic disease.
Evidence obtained within these studies suggests that c-Myb plays an important role in mammary gland development and tumourgenesis. Although it may be difficult to directly target c-Myb in malignant disease, alternative anti-tumoural therapy may be developed against c-Myb-regulated target genes that are also implicated in mammary tumours. Collectively my thesis studies have advanced our understanding of c-Myb in mammary cancer initiation, progression and as a direct or indirect therapeutic target.
Dwyer, Virginia Michelle Gregory 1955. "A STUDY OF PINEAL GLAND POLYPEPTIDES AND PROTEINS BY POLYACRYLAMIDE GEL ISOELECTRIC FOCUSING (PAG-IEF) AND TWO-DIMENSIONAL ELECTROPHORESIS (2DE) (BRAIN REGIONS)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276560.
Full textLessey, Andrew James. "The role of C-type natriuretic peptides (CNP) on pituitary development and body growth in zebrafish : molecular investigations of neuroendocrine development." Thesis, Royal Veterinary College (University of London), 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701675.
Full textAhn, Jae Suk. "Regulation of P2Y₂ nucleotide receptor expression in salivary glands." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012944.
Full textAntonica, Francesco. "Modelling thyroid embryogenesis using embryonic stem cells." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209551.
Full textFor the identification of new genes and molecular events controlling thyroid organogenesis it would be useful to develop an in vitro cellular model to recapitulate thyroid embryogenesis in a dish. Embryonic Stem Cells (ESCs) have recently emerged as system model to recapitulate the embryogenesis of several tissues in vitro.
Induced overexpression of defined transcription factors has been shown to have a directing effect on the differentiation of pluripotent stem cells into specific cell types. In this thesis I show that a transient overexpression of the transcription factors NKX2.1 and PAX8 is sufficient to direct the differentiation of murine ESCs into thyroid follicular cells (TFC) and promotes in vitro self- assembly of TFC into three-dimensional follicular structures, when associated to a subsequent thyrotropin (TSH) treatment. Cells differentiated by this protocol showed significant iodide organification activity, a hallmark of thyroid tissue function. Importantly, athyroid mice grafted with mESC-derived thyroid follicles show normalization of plasma T4 levels with concomitant decrease of plasma TSH. In addition, a full normalization of body temperature at 4 weeks after transplantation was observed. Together, these data clearly demonstrate that grafting of our mESC-derived thyroid cells rescues the hypothyroid state and triggers symptomatic recovery along with the normalization of plasma hormone concentrations. The high efficiency of TFC differentiation and follicle morphogenesis in our system will provide an unprecedented opportunity for future studies to decipher regulatory mechanisms involved in embryonic thyroid development, a major research need towards an improved understanding of the molecular mechanisms underlying congenital hypothyroidism, the most common congenital endocrine disorder in humans.
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished
Castanet, Mireille. "Mécanismes moléculaires impliqués dans les anomalies du développement de la glande thyroi͏̈de." Paris 5, 2002. http://www.theses.fr/2002PA05N124.
Full textThyroi͏̈d dysgenesis (TD) are thyroid developmental abnomalities, including athyreosis, hemithyroi͏̈d, ectopic and hypoplasic thyroid gland. Up to now, four genes have been schown to be involved in this disorder : TTF-1 (Thyroi͏̈d Transcription Factor 1), TTF-2, PAX8 and the gene encoding for the receptor of the thyroi͏̈d stimulating hormone. In this study; we firstly demontrated that congenital hypothyroi͏̈dism due to TD had a familial character. We then performed linkage analysis that showed co-segregation between the disorder and at least one of the for candidate loci in the majority of the families studied. We then identified 7 mutations in 17 subjets affected by TD, thus confirming the role of these 4 genes
Weistroffer, Béatrice. "Caractérisation des cellules épithéliales mammaires bovines sécrétrices en culture primaire." Vandoeuvre-les-Nancy, INPL, 1994. http://www.theses.fr/1994INPL076N.
Full textGasperis, Alexia de. "Expression et fonctions biologiques de l’isoforme ΔNp63." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10275.
Full textTP63 gene belongs to the TP53 tumor suppressor gene family. It encodes several isoforms. One of these, truncated in its amino-terminal end and called ΔNp63, displays oncogenic properties. It is involved in tumor progression and chemoresistance and is overexpressed in some tumor types. The first part of my work consisted of identifying the transcription factors involved in the regulation of the ΔNp63 promoter. I have shown that ΔNp63 expression is inhibited by p53 and activated by ΔNp63 itself and by β-catenin in hepatocellular carcinoma and esophageal squamous cell carcinoma cell lines. Under physiological conditions, one of the cell types in which ΔNp63 is expressed is the mammary basal cell. The “basal-like” mammary tumor sub-type seems to stem from basal cells. As some of these tumors exhibit overexpression of ΔNp63, we hypothesized that this isoform could be involved in the genesis of basal-like tumors. In the second part, I have shown that ΔNp63 expression can be increased in mammary cells cultivated in the presence of human embryonic fibroblast supernatant. Identifying the soluble factors responsible for this increase is in progress. In parallel, I have evaluated the biological consequences of ΔNp63 overexpression in terms of proliferation, cell motility and survival of normal and malignant immature mammary cells. The main modifications relate to (i) the differentiation status, ΔNp63-overexpressing cells exhibiting a more immature phenotype; (ii) the balance between migration and adhesion that is in favor of this latter. ΔNp63 seems to be at the crossroads of proliferation, adhesion, differentiation and motility, processes implicated in tissue formation and homeostasis, but whose alteration may lead to tumor initiation and progression and to metastatic dissemination. My work provides information on the role of this isoform in these processes and should allow better understanding of the genesis of some tumor types, in particular basal-like breast carcinomas
Seil, Michèle. "Contribution à l'étude des réponses cellulaires secondaires à l'activation de récepteurs purinergiques ionotropes dans les gandes salivaires et les macrophages de souris." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209926.
Full textNous avons dans un premier temps confirmé par Western blot et par des dosages de la concentration intracellulaire de calcium ([Ca2+]i) que les deux types de cellules étudiés expriment des récepteurs P2X4 et P2X7 fonctionnels.
Nous nous sommes alors concentrés sur deux réponses impliquées dans la protection de l’hôte contre les agressions et l’élimination de pathogènes :la production d’espèces réactives de l’oxygène (ROS) ainsi que la sécrétion de la cytokine pro-inflammatoire interleukine-1beta (IL-1beta). Nos résultats montrent que la production de ROS en réponse à l’ATP extracellulaire est secondaire à l’activation d’une NADPH oxydase dans les deux types de cellules. Cette réponse est médiée par les récepteurs P2X7 ainsi que, dans les macrophages, par d’autres récepteurs purinergiques comme par exemple les récepteurs P2X4 et des récepteurs P2Y. Dans les glandes exocrines, contrairement aux macrophages, la protéine kinase C ainsi que ERK1/2 interviennent dans l’activation de la NADPH oxydase.
Par la suite nous avons comparé la régulation de l’expression et de la sécrétion d’IL-1beta par les macrophages et les glandes sous-maxillaires. Nous avons observé que l’IL-1beta est présente dans la salive collectée chez des souris injectées par de la pilocarpine. Des analyses par ELISA, RT-PCR et Western blot montrent que la cytokine est exprimée de manière constitutive par les cellules acineuses et ductales des glandes sous-maxillaires, à un niveau plus élevé que dans les macrophages. Contrairement aux cellules phagocytaires, l’expression de la cytokine dans les cellules des glandes salivaires n’est pas augmentée suite à la stimulation par des lipopolysaccharides. De même, dans ces cellules l’ATP n’a pas provoqué la sécrétion d’IL-1beta malgré l’efflux de K+ secondaire à l’activation des récepteurs P2X7.
Dans une dernière série d’expériences nous avons évalué les effets du peptide antimicrobien CRAMP sur les macrophages murins. Le CRAMP a inhibé toutes les réponses secondaires à l’activation des récepteurs P2X7 (ouverture du canal cationique, formation de pore, production de ROS, libération d’IL-1beta, d’acide oléique et de lactate déshydrogénase). L’inhibition par le CRAMP de l’augmentation de la [Ca2+]i en réponse à l’ATP n’était pas médiée par les récepteurs aux peptides formylés car les agonistes de ces récepteurs n’ont pas bloqué cette augmentation. Le CRAMP n’a pas eu d’effet sur l’augmentation de la [Ca2+]i secondaire à l’activation des récepteurs P2X4 par une combinaison d’ATP et d’ivermectine.
Nos expériences ont révélé que les récepteurs P2X7 sont couplés à diverses voies de signalisation dans les macrophages et dans les glandes exocrines. Les voies activées diffèrent en fonction du type de cellules. Nous avons également conclu que les peptides antimicrobiens de la famille de cathélicidines ne sont pas des agonistes universels des récepteurs P2X7.
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished
Panzuti, Clémence. "Sevrage précoce et alimentation post-sevrage chez la chevrette : Impacts sur les performances zootechniques et sur le développement mammaire." Thesis, Rennes, Agrocampus Ouest, 2018. http://www.theses.fr/2018NSARB313/document.
Full textControl of husbandry management is essential to produce female goat kids that fully express their milk potential during their career. It involves the determination of key periods during growth, particularly for the mammary gland development. The objective of this thesis was to determinate the effects of early weaning combined with different post-weaning feeding strategies on the performances of alpine goat kids as well as on their mammary gland development. On the one hand, we showed that early weaning at 10 kg of body weight did not affect body development, reproductive parameters or milk production (MP). On the other hand, a high concentrate intake during the rearing period increased body development and the weight of mammary glands.However, this did not impact the development of mammary parenchyma during the pre-pubertal phase or at the beginning of gestation, nor even the proportion of Mammary Epithelial Cells (MEC). The proliferation of MEC was identical regardless of the amount of concentrate ingested. MP was not affected by increasing concentrate intake. Modifying the energy and protein concentration of the concentrate in the pre-pubertal period had no effect on growth, reproductive performance, mammary gland development or mammary parenchyma development. Therefore, goats seem to adapt to changes in feeding strategies without a negative effect of the increase in growth on their ability to produce milk
Kesse, Mea Albert. "Glandes salivaires palatines et prothèse totale maxillaire." Nantes, 1986. http://www.theses.fr/1986NANT1554.
Full textLiégeois-Chauvel, Catherine. "Pathologie tumorale des glandes salivaires de l'enfant." Nantes, 1986. http://www.theses.fr/1986NANT1530.
Full textGrabek, Anaëlle. "Dimorphisme sexuel du cortex surrénalien dans le renouvellement cellulaire et les pathologies." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR4018.
Full textSignificant differences between men and women are observed in terms of prevalence to adrenal cortical diseases. In particular, women are up to 6 times more likely than men to develop tumors of the adrenal cortex. Despite those striking disparity, differences and similarities in adrenal cortex renewal between sexes have yet to be investigated. The adrenal gland is a vital organ maintaining body homeostasis through the secretion of steroid hormones. It is composed of two endocrine glands, the medulla and the cortex, that is further divided into concentric zones, from the outer to the inner: the zona glomerulosa, the zona fasciculata and a zona reticularis in human or an X-zone in mice. The cortex is surrounded by a capsule that is further enveloped by a layer of mesothelial cells. In the adult stage, the adrenal cortex undergoes constant cellular renewal. Progenitor cells, located in the outer cortex, proliferate and give rise to new steroidogenic cells that centripetally migrate within the cortex, transdifferentiating along the way until they reach the border with the medulla and enter into apoptosis. During my thesis, I have shown that cell renewal in the adrenal cortex is highly sexually dimorphic with the female cortex being fully replaced in less than 3 months, while in males tissue renewal takes about 9 months. In addition, while male cortical renewal relies on progenitors located in the zona glomerulosa, the female cortex also recruits cells from the capsule to replenish the steroidogenic cell population. Finally, using sex reversal mouse models, gonadectomy and dihytrotestosterone treatments, I have identified an inhibitory role of male androgens on the proliferation and recruitment of capsular cells. In parallel, I have also studied a mouse model ectopically expressing Rspo1 in steroidogenic cells. Careful analysis of this model has evidenced the development of cortical hyperplasia and tumors in aging mice, a phenotype that was found to be significantly more pronounced in female than male. In addition, while male adrenals show signs of cellular degeneration in the adrenal cortex as early as 6 weeks of age, this histology is only observed in females of 12 months of age. Together, these results highlight profound differences between male and female in tissue homeostasis and phenotype development. These differences could offer an explanation to the unequal prevalence to adrenal diseases in men and women
Ghebrealfa, Kahsai Negassi. "Chemical characterisation of the uropygial secretion of Rhinopomastus cyanomelas." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/53731.
Full textENGLISH ABSTRACT: The uropygial gland of most birds produces a variety of hydrocarbons, lipids, waxes, fatty acids, alcohols and other organic compounds. These compounds have two widely recognized functions, viz. they are considered essential for the maintenance of a good plumage condition, and may be used for fungicidal, bactericidal or other hygienic purposes. Scimitar-billed woodhoopoes, Rhinopomastus cyanomelas, are groupterritorial birds that live in groups comprising between two and twelve individuals. Individuals enter the roost cavities shortly after sunset and exit the following morning soon after sunrise. During the period that the birds are inside the roost, they are vulnerable to a range of vertebrate predators, including snakes, genets and rats. When disturbed while roosting, woodhoopoes immediately face away from the threat hence presenting their uropygial glands in the direction of the threat. Typically, a drop of brown, highly pungent secretion is then formed at the tip of the papilla to the uropygial gland, and kept in place by a few tuft-like feathers. This response pattern has led some observers to believe that the secretion serves an anti-predatory role. It has been found that the synthetic volatile constituents of the uropygial secretion of the green woodhoopoe, P. purpureus, individually or as a mixture, have potent defensive properties against feline and reptilian predators. In addition, the compounds also showed activity against a range of bacteria. The aim of the present study was to determine the chemical composition of the uropygial secretion of the scimitar-billed woodhoopoe, Rhinopomastus cyanomelas, as a first step towards the evaluation of, inter alia, the semiochemical function of the secretion. Using gas chromatography-mass spectrometry, 179 constituents of the uropygial secretion of the scimitar-billed woodhoopoe have been identified. The majority of the constituents of the secretion are branched and unbranched aldehydes (aliphatic and aromatic), acids (aliphatic and aromatic), sulfides and ketones. This group of volatile compounds is responsible for the obnoxious odour of the secretion and possibly also for its defensive action against predators. The secretion also contains a large number of branched and unbranched alkanes and wax esters. The chemical composition of the secretion was compared with the secretion of P. purpureus as well as with that of the hoopoe, Upupa africana. The uropygial gland secretion of the scimitar-billed woodhoopoe is quite similar to that of the green woodhoopoe, although it is much more complex than that of the green woodhoopoe. In contrast to the uropygial secretions of the green and the scimitar-billed woodhoopoes, the secretion of Upupa africana does not have a strongly obnoxious odour and it also does not contain large quantities of alkanes and wax esters.
AFRIKAANSE OPSOMMING: Die uropigiale klier van die meeste voëls produseer 'n verskeidenheid van koolwaterstowwe, lipiede, was-esters, vetsure, alkohole en ander organiese verbindings. Hierdie verbindings het twee algemeen erkende funksies, naamlik die instandhouding van die goeie kondisie van die vere, en 'n swam- en kiemdodende werking. Swartbekkakelaars (Engels: scimitar-billed woodhoopoes ), Rhinopomastus cyanomelas, is groep-territoriale voëls wat in groepe van tussen twee en twaalf saam woon. Individue gaan hul neste net na sononder binne en verlaat dit weer die volgende oggend net na sonsopkoms. Terwyl die voëls binne die neste is, is hulle kwesbaar ten opsigte van aanval deur verskeie gewerwelde roofdiere, insluitende slange, muskeljaatkatte en rotte. Wanneer hulle in hul neste gesteur word, sal kakelaars onmiddellik wegdraai van die bedreiging sodat die uropigiale klier in die rigting van die bedreiging gekeer is. 'n Druppel bruin, uiters onwelriekende afskeiding vorm dan by die punt van die papil na die uropigiale klier, en word in posisie gehou deur 'n verekwassie. Hierdie gedragspatroon het aanleiding gegee tot die gedagte by sommige waarnemers dat die afskeiding as afweerstof teen roofdiere dien. Daar is gevind dat die sintetiese vlugtige komponente van die uropigiale afskeiding van die groenkakelaar, P. purpureus, individueel of as 'n mengsel, sterk afweer-eienskappe teen katte en reptiele toon. Daarbenewens het die verbindings ook aktiwiteit getoon teen 'n reeks van bakterieë. Die doel van die huidige studie was om die chemiese samestelling van die uropigiale afskeiding van die swartbekkakelaar, Rhinopomastus cyanomelas, te bepaal as 'n eerste stap met die oog op die evaluering van, onder andere, die semiochemiese funksie van die afskeiding. Deur van gaschromatografie-massaspektrometrie gebruik te maak, is 179 komponente van die uropigiale afskeiding van die swartbekkakelaar geïdentifiseer. Die meeste van die komponente is vertakte en onvertakte aldehiede (alifaties en aromaties), sure (alifaties en aromaties), sulfiede en ketone. Hierdie groep vlugtige verbindings is verantwoordelik vir die afstootlike reuk van die afskeiding en waarskynlik ook vir sy afweer-aksie teen roofdiere. Die afskeiding bevat ook 'n groot aantal vertakte en onvertakte alkane en wasesters. Die chemiese samestelling van die afskeiding is vergelyk met die van P. purpureus sowel as dié van die hoepoe, Upupa africana. Die uropigiale klierafskeiding van die swartbekkakelaar stem tot 'n groot mate ooreen met dié van die groenkakelaar, alhoewel dit veel meer kompleks is as dié van die groenkakelaar. In teenstelling met die uropigiale afskeidings van die groen- en die swartbekkakelaars, het die afskeiding van Upupa africana nie 'n afstootlike reuk nie en bevat dit ook nie groot hoeveelhede alkane en was-esters nie.
Çevik, Aras Hülya. "Secretory and anti-inflammatory actions of some gastro-intestinal hormones in salivary glands /." Göteborg : Institute of Neuroscience and Physiology, Section of Pharmacology, The Sahlgrenska Academy at Gothenburg University, 2009. http://hdl.handle.net/2077/20460.
Full textDecrem, Yves. "Etude de l'inhibition des mécanismes d'hémostase par des protéines de glandes salivaires de la tique Ixodes ricinus." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210501.
Full textLe Service de Biologie Moléculaire des Ectoparasites (anciennement Service de Génétique Appliquée) a identifié un grand nombre de séquences d’ARNm induites spécifiquement dans les glandes salivaires de la tique au cours de son repas sanguin. Deux d’entres-elles ont servi de point de départ à ce travail :il s’agit de seq16 (renommée Metis1) et de seq7 (renommée Ir-CPI).
Le travail sur la séquence seq16 a conduit à l’identification d’une nouvelle famille de 5 métalloprotéases (nommée Metis pour Metalloprotease from Ixodes ricinus). L’analyse des séquences a permis de les associer à certaines métalloprotéases hémorragiques de venin de serpent. Bien que les 5 métalloprotéases décrites possèdent toutes les mêmes caractéristiques au niveau de leur séquence et de leur profil d’expression dans les glandes salivaires, les résultats d’analyse phylogénétique, d’étude de variation antigénique, de leur mode d’activation et de leur spécificité d’action permettent de les diviser en 3 sous-familles. L’utilisation de la technique d’ARN interférence en in vivo et l’analyse vaccinale soulignent le rôle essentiel de la famille Metis dans les premières heures du repas de la tique et de manière générale dans la réussite du repas sanguin. Enfin, des études d’activité ont montré que certains membres de la famille ont une activité fibrino(gèno)lytique ;plus particulièrement, la protéine Metis4 possède une activité protéolytique envers la gélatine, la caséine, la fibronectine et le fibrinogène. Ces études ont montré également un mode d’activation original ;plutôt que d’être activée par une pro-séquence en amino-terminal, Metis4 s’active spontanément en perdant un peptide à son extrémité carboxy-terminale.
Le travail sur la séquence seq7 a conduit à la caractérisation d’un nouvel inhibiteur de sérines protéases. Cette protéine, nommée Ir-CPI pour « Ixodes ricinus - Contact Phase Inhibitor », possède un motif kunitz et est capable d’inhiber de manière importante la voie intrinsèque de la coagulation et dans une moindre mesure la fibrinolyse. Grâce à la technique d’ARN interférence, l’activité de la protéine recombinante a été corrélée à l’activité de la protéine native exprimée dans les glandes salivaires. Ir-CPI inhibe dans un plasma humain l’activation réciproque du facteur XII, de la prékallikréine et du facteur XI, et se fixe spécifiquement à la forme activée de ces trois facteurs. De plus, Ir-CPI est capable de bloquer la fibrinolyse en inhibant spécifiquement la plasmine. Enfin, les résultats obtenus sur deux modèles animaux indépendants établissent l’effet d’Ir-CPI comme agent anti-thrombotique en empêchant la formation de caillot et de manière remarquable sans altérer l'équilibre hémostatique.
En conclusion, ce travail a identifié des protéines anti-hémostatiques qui agissent soit comme inhibiteur de protéases empêchant la coagulation soit comme protéases facilitant la lyse du caillot. Cette redondance de protéines anti-hémostatiques illustre remarquablement la capacité de la tique à agir en synergie sur des facteurs essentiels aux mécanismes de défense de l’hôte.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Delverdier, Maxence. "Histomorphométrie de la glande thyroïde du rat." Toulouse, INPT, 1991. http://www.theses.fr/1991INPT013A.
Full textGresson, Régis. "Segmentation et reconstruction tridimensionnelle du foyer de microcalcifications mammaires." Vandoeuvre-les-Nancy, INPL, 1998. http://www.theses.fr/1998INPL108N.
Full textGagniac, Laurine. "Physiologie et physiopathologie des effets membranaires du récepteur des œstrogènes alpha (ERα) dans la glande mammaire." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30101.
Full textIt is well established that the 17-estradiol is involved in the development and homeostasis of reproductive and extra-reproductive tissues, particularly the mammary gland. Estradiol classically binds to Estrogen Receptor (ERα), which is a member of the nuclear receptor superfamily. ER mediates nuclear (transcription) and plasma membrane (signaling) ERα function. Interestingly, the membrane initiated steroid signaling (MISS) required a post translational modification of the receptor: palmitoylation of the human Cys-447 or the murine Cys-451 counterpart. The main objectives of my PhD thesis were to decipher the physiological role of membrane ERα in mammary gland development and to understand how the membrane ER signaling impact breast cancer. To do so, we used the transgenic mouse model C451A-ER in which the single point mutation (C451A) was introduced to abolish palmitoylation of ER (membrane addressing signal). We demonstrate that the point mutation of the palmitoylation site of ER alters the paracrine signaling of luminal epithelial cells and by consequence the repopulation properties of the mammary stem cells. We also studied the involvement of the membrane effects of the Estrogen Receptor ERα in the 17β-estradiol response dose of the mammary gland. Finally, by breeding the C451A-ER mice with the widely used transgenic mice model of tumorigenesis (PyMT), we provide the first evidence that the membrane ERα influences tumorigenesis. These findings pave the way on an unexpected role of non-genomic function of ERα in the mammary gland physiology and physiopathology
Benayoun, Sandra. "Glandes corticosurrénales : régulation de l'activité de l'axe corticotrope." Paris 5, 1996. http://www.theses.fr/1996PA05P048.
Full textLebsir, Dalila. "Toxicologie de l'iode stable : Etude in vivo des effets biologiques associés à une prophylaxie répétée par l'iodure de potassium." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS423.
Full textFollowing nuclear accidents, uranium fission products such as radioactive iodines are released into the environment. Humans are likely to be exposed to these elements mainly through inhalation of air and / or ingestion of contaminated food. Iodine 131 is known to be responsible for increasing the incidence of thyroid cancer. One of the available countermeasures is the ingestion of a single dose of potassium iodide (KI) tablets to saturate the thyroid gland with stable iodine and thus prevent the uptake of the radioactive isotope.Repeated releases of radioactive iodine during the two major accidents Chernobyl and Fukushima have highlighted the weaknesses of this measure, repeated intake of KI maybe necessary. In the literature there is little clinical and preclinical data on the repeated intake of stable iodine, regarding its use it has not been described. The iodine doctrine as well as the Marketing Authorization (MA) of the KI considers only the single taking, to renew exceptionally in the adult population. Iodine is known to be a key component of thyroid function, playing a dual role as both a substrate and a regulator of the thyroid. If its presence is essential for the synthesis of thyroid hormones, its excess exerts a transient inhibitory effect on this synthesis known as the Wolff-Chaikoff effect. Thyroid hormones affect the development and function of almost all organs of the body (brain, heart, bone ...), the slightest variation in their level can impact the homeostasis of the body. Hence, the toughness of applying repeated KI intake in the absence of biological and toxicological data. To fill this gap and find a solution in the event of repeated exposure, the French research program PRIODAC: repeated potassium iodide prophylaxis in accidental situation (ANR / RSNR), of which this thesis is part, aims to define the modalities of repeated administration of KI in all age groups (in utero, adult and elderly), and evaluate the biological consequences on the the body’s major physiological functions. Three models of Wistar rats were used in this work: the reference model adult rat (3 months), the first sensitive model offspring (exposed during gestation) and another sensitive model the older rat (12 months ), these three models received 8 consecutive intake of KI 1mg / kg / 24h. And the effects were assessed at long-term (30 days post-prophylaxis). On the reference model, there was no long-term adverse impact of repeated KI intake (Lebsir, Cohen et al. 2018; Lebsir, Manens et al. 2018). On the other hand, sensitive models reveal several long-term effects; the offspring exhibited impaired motor coordination and variation of the expression of some key brain genes. And in the elderly rat urinary biochemistry, expression of some key genes of the cardiovascular function, as well as the renin-angiotensin-aldosterone system were significantly impacted by the treatment. In conclusion, the results obtained show the toxicological safety of KI administered at 1 mg / kg every 24 hours for 8 days in the adult model, and the harm of this prophylactic scheme in sensitive models in utero and elderly. These results were sent to the French central pharmacy of armies and will serve as input data for good laboratory practice studies that eventually will contribute to the evolution of the iodine doctrine and KI MA
Olsson, Tommy. "Endocrine studies in stroke patients." Doctoral thesis, Umeå universitet, Medicin, 1989. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101772.
Full textS. 1-66: sammanfattning, s. 69-190: 6 uppsatser
digitalisering@umu
Bourdon, David M. "Serotonin receptors in mammalian salivary glands." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012950.
Full textChiche, Aurélie. "Etude des cellules souches et progénitrices mammaires et de leur contribution à la tumorigenèse : rôle des facteurs de transcription Myc et p53." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00924981.
Full textKrown, Kevin Alan. "Pituitary changes in force-molted hens." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185205.
Full textSá, Josiane Costa Rodrigues de. "Comparação microscópica de glândulas sublinguais de cadáveres humanos e de pacientes desdentados portadores de tumefações do soalho da boca relacionadas às glândulas sublinguais: estudo morfológico e morfométrico." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/25/25132/tde-05112009-100358/.
Full textMouth floor enlargements related to sublingual glands in edentulous or partially edentulous patients may be present, impairing denture fitting. Sometimes surgical treatment is needed. Erroneously, these enlargements have been attributed to glandular hyperplasia. Changes due to aging process have been suggested as a possible cause but the etiopathogenesis continues uncertain. The aim of the study was to explain the cause of mouth floor enlargements in edentulous patients. Human sublingual glands from necropsies and glands removed in pre-prosthetic surgical treatment of mouth floor enlargements in edentulous patients were microscopically compared. Morphological and morphometric studies were performed in individuals of similar chronological ages. Results were analyzed with significance set for p0,05. The morphological study analyzed: acinar atrophy (p=0,758), acinar autolysis (p=0,014), focal (p=1,000) and diffuse mononuclear infiltrate (p=0,142), replacement of parenchyma by fibrous tissue (p=0,547), replacement of parenchyma by adipose tissue (p=0,547), focal (p=0,192) and diffuse mucus overflow (p=0,758) and oncocytosis (p=0,883). The variables ducts and/or duct-like structures (p=1,000) and congested blood vessels (p=0,043) were classified in absent and present. The volumes densities of acini (p=0,752), ducts (p=0,444), stroma (p=0,209) and adipose tissue (p=0,794) were determined by the morphometric study. The results showed statically significant difference to the microscopic aspects: autolysis (p=0,014) and congested blood vessels (p=0,043). The microscopic aspects of the sublingual glands in mouth floor enlargements in edentulous patients revealed the normal aging process of the salivary glands. Concluding, the sublingual glands in mouth floor enlargements in edentulous patients are not pathological glands.