Journal articles on the topic 'Geo-Ethnic background'

Background: parkrun has been successful in encouraging people in England to participate in their weekly 5km running and walking events. However, there is substantial heterogeneity in parkrun participation across different communities in England: after controlling for travel distances, deprived communities have significantly lower participation rates. Methods: This paper expands on previous findings by investigating disparities in parkrun participation by ethnic density. We combined geo-spatial data available through the Office for National Statistics with participation data provided by parkrun, and fitted multivariable Poisson regression models to study the effect of ethnic density on participation rates at the Lower layer Super Output Level. Results: We find that areas with higher ethnic density have lower participation rates. This effect is independent of deprivation. Conclusions: An opportunity exists for parkrun to engage with these communities and reduce potential barriers to participation.

Background: parkrun has been successful in encouraging people in England to participate in their weekly 5km running and walking events. However, there is substantial heterogeneity in parkrun participation across different communities in England: after controlling for travel distances, deprived communities have significantly lower participation rates. Methods: This paper expands on previous findings by investigating disparities in parkrun participation by ethnic density. We combined geo-spatial data available through the Office for National Statistics with participation data provided by parkrun, and fitted multivariable Poisson regression models to study the effect of ethnic density on participation rates at the Lower layer Super Output Level. Results: We find that areas with higher ethnic density have lower participation rates. This effect is independent of deprivation. Conclusions: An opportunity exists for parkrun to engage with these communities and reduce potential barriers to participation.

Ethnic and linguistic changes of the Belarusian population at the turn of the 21th centuryThe first part of the article presents historical background of the origin of the Belarusian nation, located in the area of a confrontation between Russia and Poland. This rivalry was won by Russia, and in effect Belarusian land was incorporated into the Russian Empire, and later into the Soviet state. The next part presents the 20th century ethnic structure as the consequence of the Bolshevik Revolution and World Wars I and II, resulting in some border changes, war loses and migration movements. The main part of the article deals with the ethnic and language changes which occurred in the last decade of the 20th and in the first decade of the 21st centuries. The statistical analysis and interpretation is based on data from three population censuses (1989, 1999, 2009). An ethnic structure and linguistic situation are presented with the emphasis placed on the status of the two languages commonly used in Belarus, i.e. Russian and Belarusian, as seen in two categories: of mother language and of the language used for communication at home. The conclusions prove the expansion of popularity of the Russian language and gradual decrease of the use of the Belarusian language, both in public and at home. The processes of Russification, which had begun in the Soviet period, are intensifying despite the fact that Belarus regained its political souverianity as a country. On the basis of quantitative data the author defines specific intensity and territorial distribution of the influence of the Russian language. The final part of the article shows political and geo-political consequences of these changes in Belarus.

Abstract Background: Diseases whose treatment requires chronic transfusion therapy are relatively rare, and many have higher prevalence among certain ethnic groups and geographic regions. In these geographical regions, the patterns of care for these diseases and the epidemiology of iron overload (IOL) and other complications of treatment are currently undefined. To improve patient (pt) outcomes, it is important to understand how to diagnose, monitor, and manage these diseases. The TORS study aimed to collect information on a large number of newly diagnosed pts with various types of anemia and hemoglobinopathies to assess pt management considering diagnostic criteria and treatment pattern with iron chelation therapy (ICT) across various geographical regions. Methods: Inclusion and exclusion criteria were defined earlier by Siritanaratkul et al, EHA. 2015. Pts aged >2 years requiring chronic transfusion therapy with newly diagnosed anemias (<12 months from diagnosis), including low and intermediate-1 myelodysplastic syndromes (MDS), aplastic anemia (AA), and other transfusion-dependent (TD) anemias were enrolled. Pts were recruited from various geographical regions and were classified according to pt numbers, ethnicity and health care system as geo-1: Hong Kong, South Korea, Taiwan, Thailand; geo-2: China; geo-3: Tunisia, Morocco, Algeria, South Africa, Russia; geo- 4: Turkey. Pts were evaluated at baseline (BL) and at follow-up visits according to the standard practice for up to 3 years or until death. Results: Of the 564 pts (including 57 pts aged ≤18 years), 58.5% (n=330) were diagnosed with MDS, 31.2% (n=176) with AA, 10.1% (n=57) with other TD anemias. Diagnosis of 1 pt was missing. The mean age (±SD) was 51.9±23.87 years (range, 2-92); 49.5% of pts (n=279) were male. 97.2% (321/330) of MDS pts were classified using the WHO classification. In 89.0% of MDS pts, a risk assessment according to IPSS score was performed. Pts known to have received transfusions during the study include 92.6% (163/176) of AA, 68.4% (226/330) of MDS, and 93% (53/57) of other TD anemias. If analyzed by geographical region, 72.4% (126/174) of geo-1, 49.7% (99/119) of geo-2, 92% (115/125) of geo-3, and 70.5% (103/146) of geo-4 pts received transfusions during the study. At BL, serum ferritin (SF) was only available in 34.5% (195/564) of overall pts (50.9% [82/161] of chelated; 28% [113/403] of non-chelated pts) (Table 1). If analyzed by disease, among chelated pts, 38.4% (15/39) of AA, 57.1% (52/91) of MDS, and 48.3% (15/31) of other TD anemias had BL SF values. SF was available in 35% (20/57) of pediatric pts at BL (39.2% [11/28] of chelated; 31% [9/29] of non-chelated pts). In the overall pt population, data on ICT were available in 26% (13/50) of geo-1, 63.6% (7/11) of geo-2, 51.2% (20/39) of geo-3, and 68.8% (42/61) of geo-4 pts. At the final visit, the overall median change in SF from BL was -67.0 ng/mL. Among the pts receiving ICT (n=161), median change in SF from BL was -325.6 ng/mL (-433.5 in AA, +483.5 in MDS, and -1113.0 in TD anemias) at final visit. Among the pts without ICT (n=403), the median change in SF from BL was +116.7 ng/mL (+116.2 in AA, +163.2 in MDS and -306.5 in TD anemias). Among the pts with ICT (n=161), median change in SF from BL was +395 in geo-1, +113.5 in geo-3, and -433.5 in geo-4 at the final visit (pt data not available for geo-2). Among the pts without ICT (n=403), median change in SF from BL was +70.1 in geo-1, -170.6 in geo-2, -71.7 in geo-3, and +348.7 in geo-4 pts. Conclusions: In this large observational study, MDS was the most common disease type. This was potentially biased by site selection. Although the majority of pts received transfusion therapy leading to IOL, the awareness of IOL was low if measured by the availability of SF at BL and at each of the following visits. Consequently, many pts did not receive ICT. Interestingly, the majority of the MDS pts were classified according to WHO and stratified according to the recommended IPSS risk score, confirming that these guidelines are part of the standards of care in the clinical practice regardless of the geographic zone or the healthcare system. Overall, these results suggest that diagnosis and management practices of IOL and the underlying anemias may still be suboptimal in many parts of the world. Therefore, there is a need to improve local or regional understanding of IOL and its clinical consequences based on feasible therapeutic options in those regions. Disclosures Siritanaratkul: Janssen-Cilag: Research Funding; Novartis: Research Funding; Roche: Research Funding; Pfizer: Research Funding. Volodicheva:CELLTRION, Inc.: Research Funding. Wong:Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau. Louw:Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis Oncology: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau. El-Ali:Novartis: Employment. Han:Novartis: Employment. Losco:Novartis: Employment.

In spite of picturesque landscapes, natural beauties and authentic traditional lifestyles to be seen in East Kazakhstan, tourism is far from being developed. The Kazakh Altai (called the Kazakh Switzerland) is one the most colourful parts of the country and, indeed, all Central Asia. The attractiveness of this geographically isolated region (formerly a part of the Imperial Russia), consisting of rocky semi-deserts, vast parkland-steppes, and rugged mountain terrains, is reflected in its distinctive geological and geomorphological character, its pristine nature, and its extraordinary geodiversity and biodiversity. This study presents a roster of geotourism and ecotourism loci for the broader Altai area within a framework of sustainable development. The modelled assessment of the tourism and recreation potential is based upon multi-proxy analyses of GIS, DEM, and cartographic data. It integrates the most appealing natural (biotic and abiotic) site-specific natural features across all physiographic zones within a broad region. The most significant and representative geosites fall within three geographic sectors suitable for geo- and ecotourism. Prospects for travel to these places are enhanced by the presence of numerous prehistoric archaeological sites and historical monuments, which document the rich, multi-ethnic background of Kazakhstan and the ancient Silk Road that traverses it. These geological, environmental and cultural resources, and the regional geoheritage and environmental conservation concepts have been figured into strategies for economic growth of rural Kazakhstan. Visitors travelling to this most appealing region are constrained by climate of pronounced continentality, seasonality, geographic accessibility, the international border-zone regulations and a lack of services of an international standard.

Abstract Background: The intratumor microbiome is implicated in tumor initiation, progression, and altered immune response to cancer therapies. Furthermore, recent studies have revealed correlations between microbial abundance and racial disparities in cancer. While these investigations provide novel insights into cancer disparities research, few have investigated which racial and ethnic disparities exist for patients with female malignancies. In this study, we characterized the intratumor microbiome according to racial and ethnic disparities in common female malignancies including breast, cervical, uterine, and ovarian cancers. Methods: We examined the intra-tumoral microbiome in the breasts, cervix, uterus, and ovaries (n = 2630). Raw tumor RNA sequencing data were downloaded from The Cancer Genome Atlas (TCGA) and aligned to bacterial genomes using the PathoScope 2.0 framework and references genomes provided by the NCBI nucleotide database. Potential contaminants were identified and removed from downstream analyses by associating individual microbe abundance with total microbe abundance in each sample. Microbial abundance was correlated to race, ethnicity, and prognostic variables (Kruskal-Wallis test or Cox regression, p &lt; 0.05). Finally, we validated our results using transcriptomic sequencing data downloaded from the GEO NCBI data portal. Results: Significant dysregulation of bacterial microbes according to race and ethnicity was observed in these cancers, but most notably in breast cancer in which 6 species correlated strongly with survival. Of particular significance were Veillonella Parvula and Mycobacteroides chelonae, which were both significantly dysregulated in Black breast cancer patients, with low abundance of both species correlating to poor survival. Cupriavidus Taiwanensis and Delftia Acidovorans were more abundant in Black breast cancer patients, with high abundance correlating to poorer prognosis. Black patients were also diagnosed at significantly later cancer stages in cervical cancer. We also observed significant correlations of bacterial microbe abundance with prognostic and treatment variables in these cancers, including pathologic TNM staging, neoplasm presence, therapy outcome, and more. Conclusion: Our study is the most comprehensive to date investigating racial differences in the intra-tumoral microbiome in common female cancers. We found that differences in intratumoral microbial abundance may account in part for observed racial and ethnic disparities in cancer prevalence and progression in these cancers. Further studies are needed to investigate the specific mechanisms by which these microbes contribute to these observed cancer disparities within the tumor microenvironment. Citation Format: Matthew Uzelac, Wei Tse Li, Jaideep Chakladar, Daniel John, Weg M. Ongkeko. Racial and ethnic disparities associated with the intratumor microbiome in female cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB110.

Abstract This study examines the etymology of the principal physiographic entities of the ancient Sary-Arka area–meaning in the old Turkic language Yellowing Ridge – encompassing the present territory of parkland-steppes, rocky highlands and the adjacent mountains of North and East Kazakhstan. The current linguistic evidence points to a complex and chronologically long culture-historical development reflected by the local place names best-recorded for the major rivers and mountains (hydronyms and oronyms, respectively). Not all geo-site names are securely determined by using modern onomastics. Records of material culture provide additional multi-proxy information. Local uniformity of some toponyms across the extensive area assuming a common cultural background attests to a broader ethnic homogeneity and/or mobility of the ancient populations inhabiting this vast and geomorphically mosaic land. This suggests a close relationship and interactions (including demographic exchanges and mixing) between the past pastoral ethics in the parkland-steppe and semi-desert areas north of Lake Balkhash between the Aral Sea and the southern Urals in the West and the Alatau–Altai Mountain systems in the East. Whereas the hydronyms of the Sary-Arka may have a rather complex and not fully clear origin with a connection to the Turkic-Tatar medieval tribes and nations’ occupancy in northern Central Asia eventually modified into the present Kazakh language forms, the oronyms of the East Kazakhstan mountain ranges indicate the Mongolian roots.

Background/Aims: The present study attempted to identify the potential key genes and pathways of hyperlipidemia, and to investigate the possible mechanisms associated with them. Methods: The array data of GSE3059 were downloaded, including thirteen samples of hyperlipidemia from the Gene Expression Omnibus (GEO) database. The weighted gene co-expression network analysis (WGCNA) was performed with WGCNA package, and the salmon and midnight blue modules were found as the highest correlation. Gene Ontology annotation and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for these two modules were performed by cluster Profiler and DOSE package. A protein-protein interaction (PPI) network was established using Cytoscape software, and significant modules were analyzed using Molecular Complex Detection. Results: Five genes (histone deacetylase 4, HDAC4; F2R like trypsin receptor 1, F2RL1; abhydrolase domain containing 2, ABHD2; transmembrane 4 L six family member 1, TM4SF1; and family with sequence similarity 13-member A, FAM13A) were found with a significant meaning. When their expression levels were validated with RT-qPCR, the relative expression levels were lower (HDAC4) and higher (F2RL1, ABHD2, TM4SF1 and FAM13A) in hyperlipidemia than in normal controls (P < 0.05-0.01). Subgroup analysis showed that the relative expression levels of HDAC4 were lower, whereas those of F2RL1 and ABHD2 were higher in Maonan than in Han ethnic groups (P < 0.05). Conclusion: Except for genetic factors and environmental exposures, epigenetic influence was another mechanism of hyperlipidemia in our study populations, which needed to further confirm.

Abstract Background: Although trastuzumab and tyrosine inhibitors combined with neoadjuvant chemotherapy could significantly improve patients' pathological complete response (pCR) rate, nearly half of the patients could not achieve complete remission. Our objective was to explore the relationship between metabolic signaling pathway changes and therapeutic efficacy in patients receiving neoadjuvant therapy for HER2-positive breast cancer. Methods: Core needle biopsy specimens from HER2-positive breast cancer patients who underwent neoadjuvant therapy and radical mastectomy at Fudan University Shanghai Cancer Center between January 2017 and December 2021 were collected for RNA sequencing. According to pathological evaluation, samples (n=133) were divided into pCR and non-pCR groups. Gene differences between the two groups were further evaluated for KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis. The TCGA (The Cancer Genome Atlas, n=1091) and the HAN ethnic GEO datasets (GSE162228, GSE206, GSE48391, n=305) were used to analyze the metabolic differences between tumors and normal tissues with patients’ prognosis. Consensus clustering analysis was performed to divide patients for low and high phenylalanine-tyrosine metabolism dysregulation to analyze patients’ outcomes. The IC50 value of cell lines was tested using CCK-8 experiments. Western blot was performed to analyze the protein level changes in mTOR and glycolysis pathway. Results: We found that phenylalanine-tyrosine metabolism was significantly enriched in HER2-positive breast cancer patients. Consensus clustering analysis of TCGA and the HAN ethnic GEO datasets showed that patients with low phenylalanine-tyrosine catabolism had a significantly worse survival outcome than patients with high tyrosine metabolism (P= 0.017). In our cohort, phenylalanine-tyrosine pathway metabolic enzyme DDC was upregulated while MAOA was downregulated in non-pCR patients compared to pCR patients, suggesting the increased production of dopamine and reduced catabolism of dopamine (DA) in non-pCR tumors. In vitro experiments showed that dopamine and the knockdown of MAOA decreased cell sensitivity to pyrotinib. In addition, dopamine and clorgyline- an MAOA inhibitor, promoted the proliferation of HER2-positive cell lines under the treatment of pyrotinib. The GSEA analysis of our neoadjuvant cohort and TCGA datasets revealed that MAOA expression was associated with an inverse enrichment of the mTORC1 and glycolysis pathways. Western blot experiment results showed that dopamine or the knockdown of MAOA could activate the mTOR and glycolysis pathway Conclusions: Phenylalanine-tyrosine metabolism was significantly enriched in HER2-positive breast cancer patients. The phenylalanine-tyrosine signaling pathway may be dysregulated in HER2-positive breast cancer and patients with low phenylalanine-tyrosine catabolism have a worse prognosis. Low expression of MAOA promotes tumor resistance to HER2-targeted drugs and could serve as a therapeutic biomarker in breast cancer. Citation Format: Chih Wan Goh, Bingqiu Xiu, Jingyan Xue, Yayun Chi, Jiong Wu. Dysregulation of Phenylalanine-tyrosine Metabolic Signaling Pathway and Neoadjuvant Response in HER2-positive Breast Cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-01-01.

In the first half of the 20th century, sizeable Russian communities lived in a number of Chinese cities, including Harbin, Shanghai and Tientsin. The largest and most diverse of these was the community that grew up around Harbin in north China. By the mid 1920s, Harbin was home to one of the largest Russian diaspora communities in the world, with over 120,000 Russians and other nationalities from the former Tsarist Empire. Moreover, many Russians in Shanghai and Tientsin had links to Harbin, as their first place of domicile in China. By the late 1950s, political transformations in China had driven almost all these people elsewhere. But for many of them, their roots in China became a key aspect of their identity in emigration in their new diasporas. This paper explores the background to this unique community and the geo-political forces underpinning the various waves of migration of Russians into and out of Harbin. It analyses the complex issues of identity and citizenship Russians faced while living in Harbin, their fates determined at various points in time by the dominance of three powers – Russia, China and Japan. Drawing on the experience of my own family, whose life in Harbin and Manchuria spanned four generations over fifty years, it touches on the rich ethnic and cultural mix that lay beneath the surface of “Russian” Harbin, with particular reference to the Jewish community that once thrived there. Finally, it examines how the ‘Harbintsy’ perceive their identity in emigration and the recent changes in attitude towards them of the Chinese authorities.

Crisis phenomena threats are growing on national and global scale against the background of tightened geopolitical and geo-economic competition. Such trends as destruction and degradation, are becoming integral parts of change in the vital function of economic agents, institutional structures at different levels. Therefore, the search for an alternative paradigm for the study and assessment of the transformations of socio-economic systems (SES) is one of the topical directions in the development of economic science. In the objective conditions of constant renewal of world economic relations, proceeding from the multilevel nature of social changes, the article substantiates the need for innovative ways to search, develop and implement strategic guidelines that exclude the raw type of economic development. From the standpoint of the self-organization theory, it specifies that an open system is, as a rule, in a state of unstable equilibrium. The article proves that the purpose of theoretical research and practical actions should be the implementation of controlled effective evolutionary and revolutionary qualitative changes. At the turn of the third millennium, under the increasing impact of periodic civilizational shocks at the stages of economic and political cycles, the determinants of SES stability change over a long period. The transformation of natural factors requires scientific understanding - from motive levers into constraints on the potential for economic growth. The growing volumes of services and the virtual economy are hardly comparable with the products of the industrial sector, while the excessive polarization of incomes hinders economic dynamics. Arguments are given that the processes of changing existing SES can be accompanied by their deformation. The forces of the fall are opposed by compensatory mechanisms of reimbursement for the loss of material, human, information resources. The author focuses on the need to organize and manage the new approaches to the management of SES changes, having in mind time and space scale of the development of integral, interconnected bodies of social and economic agencies at state, corporative as well as individual levels. Crisis shocks of SES transformation are mainly linked with reasons stemming from financialization processes, weakening of sovereignty due to the expansion of global value chains, as well as from major emergencies and disasters, unexpected climate changes, etc. The article suggests improving the conceptual apparatus of transformational changes. The leading trend in modern science is interdisciplinarity. Integration of various scientific disciplines should affect both economics and institutional, social, spiritual, ethnic, moral spheres of life.

Background:Rheumatoid arthritis (RA) has been described in virtually every ethnic population. Most RA patients harbor anti-modified protein antibodies (AMPAs), including anti-citrullinated protein (ACPA), anti-carbamylated protein (anti-CarP), anti-malondialdehyde acetaldehyde (anti-MAA), and anti-acetylated protein antibodies (AAPA). However, it is unclear whether differences exist in the AMPA response between different ethnic groups. Such differences could provide new clues to genetic and environmental factors contributing to autoantibody development.Objectives:To investigate the prevalence of different AMPA in four ethnically diverse RA populations, and their association with smoking.Methods:Enzyme-linked immunosorbent assays were used to measure anti-CarP IgG, anti-MAA IgG (both in-house), and anti-acetylated vimentin IgG (Orgentec) in ACPA-positive sera of Dutch (NL, n=103), Japanese (JP, n=174), Canadian First Nations People (FN, n=100), and black South Africans (SA, n=67) fulfilling the 1987 ACR classification criteria for RA. Ethnicity-matched local healthy controls were used to calculate cohort-specific cut-offs. Logistic regression was used to identify whether ever-smoking was associated with AMPA seropositivity in each cohort, corrected for age, gender, and disease duration. Random-effects meta-analysis was used to pool the resulting odds ratios (OR).Results:For all three AMPAs, median levels were higher in FN and especially SA than NL and JP patients (Figure 1). The median autoantibody levels in arbitrary units (in % of patients positive) for NL, JP, FN and SA RA patients were: anti-CarP IgG: 1157 (47%), 994 (43%), 1642 (58%) and 2336 (76%) (p<0.001); anti-MAA IgG: 131 (29%), 179 (22%), 251 (29%) and 257 (53%) (p<0.001); AAPA: 133 (20%), 136 (17%), 153 (38%) and 316 (28%) (p<0.001). Prevalence, meaning positivity, also differed significantly between cohorts for all AMPAs (p<0.001).There were also marked differences in total IgG levels in mean (SD) g/L: 13 (4) for NL, 17 (6) for JP, 18 (6) for FN, and 25 (8) for SA (p<0.001). When the autoantibody levels were normalized to total IgG, the differences in became less pronounced between cohorts (Figure 2). The median arbitrary units per g/L Total IgG for NL, JP, FN and SA RA patients were: anti-CarP IgG: 54, 25, 53, and 79; anti-MAA IgG: 6, 5, 8, and 9; and AAPA: 2, 2, 2, and 3, suggesting that autoantibody level differences may partly correspond to cohort-specific differences in total IgG, although the overall trend of higher levels in SA persisted. There was no association between smoking and anti-CarP or anti-MAA positivity, with pooled OR (95% CI) of 1.31 (0.79-2.18) and 0.85 (0.46-1.56), respectively. However, smoking was positively and consistently associated with AAPA positivity in each cohort: pooled OR (95% CI) of 2.01 (1.06-3.81).Conclusion:In these ACPA-positive ethnically diverse RA populations, levels and prevalence of various AMPAs differ, suggesting that ethnic background and environment may influence the development of the autoantibody response in RA. Despite these differences, our results imply smoking as a consistent risk factor for AAPA across different ethnic backgrounds.Disclosure of Interests:Emma C. de Moel: None declared, Veerle Derksen: None declared, Leendert A Trouw: None declared, Chikashi Terao: None declared, Mohammed Tikly: None declared, Hani El-Gabalawy: None declared, Holger Bang Grant/research support from: Employee of Orgentec Diagnostika, Thomas Huizinga Grant/research support from: Ablynx, Bristol-Myers Squibb, Roche, Sanofi, Consultant of: Ablynx, Bristol-Myers Squibb, Roche, Sanofi, Rene Toes: None declared, Diane van der Woude: None declared

Рассматривается один из основных ландшафтных кодов культурной географии – «вода/река», его анализ позволит понять особенности формирования хозяйственной специфики и духовных ценностей бродячих охотничье-рыболовных племен Восточной Сибири. Территории кочевания этих племен за последние 2 тыс. лет существенно сократились, и в настоящее время Нелемнинский наслег – земли родовой общины «Тэки Одулок» в Верхнеколымском улусе Республики Саха (Якутия) – единственное в своем роде место компактного проживания потомков древнего населения. Для северных кочевников юкагиров (охотников и рыболовов) вода/река имела культурообразующее значение: она кормила, помогала перемещаться с места на место, служила ориентиром на местности. Важность водных ресурсов рассматривается в статье через призму этнической истории юкагирского народа. Показано, что современная уникальная культура северных номадов Верхней Колымы сложилась благодаря двум основным факторам: сохранности гомогенной «кормящей» территории и незначительной трансформации традиционного годового хозяйственного цикла. Природно-климатические условия и полукочевой уклад жизни выработали у этой группы юкагиров устойчивые стереотипы мышления и поведения и определенную систему ценностей и предпочтений. Их пространственные представления формировались под влиянием ландшафта, в частности водной системы территории кочевания. Традиционно в период промысла родовые группы лесных юкагиров длительное время находились в изоляции – такое положение сохранялось вплоть до начала XX в. Подобные условия предполагали разного рода опасности и риски, реальные и воображаемые. При отсутствии дорог в теплое время года и в силу большой заболоченности территории древний ландшафтный код «вода/река» определял номадический характер культуры юкагиров. Водная система в представлениях охотников и рыболовов Верхней Колымы запечатлена в духовной и материальной культуре как амбивалентная стихия. В геокультурном пространстве потомков аборигенных северных номадов концепт «водная стихия» традиционно построен на культурных смыслах, образах и символах. Сегодня присваивающий характер хозяйства лесных юкагиров и сохранение значимости ландшафтного кода «вода/река» позволяют говорить, что в обозримом будущем в культуре этого народа по-прежнему будут присутствовать элементы древних языческих религиозно-мифологических представлений. The article considers one of the main landscape codes of cultural geography – water/river, which in part determined the specifics of economy and spiritual values of the wandering hunting tribes of Eastern Siberia. The areas of nomadic hunting and fishing tribes of Eastern Siberia have significantly decreased over the past two thousand years, and currently the territory of the Nelemninsky National Council and the tribal community “Teki Odulok” in the Verkhnekolymsky region (ulus) of the Republic of Sakha (Yakutia) is the only place of compact residence of descendants of the ancient population. Among the northern nomads –Yukagirs-hunters and fishermen, the water/river landscape code was of a cultural-forming significance; water/river provided food, transport and served as a reference point in space. The significance of water resources is considered in diachronic and synchronous ranges against the background of the ethnic history of the Yukagir people with the involvement of archival and literary data. It is shown that the modern functioning of the unique culture of northern nomad dog breeders in the Upper Kolyma is due to the preservation of a homogeneous feeding territory and a minor transformation of the traditional annual economic cycle. The territorial community, the organization of living space in such climatic conditions and the semi-nomadic way of life have developed stable stereotypes of thinking and behavior, a system of values and preferences for this group of Yukagirs. The understanding of space of the nomad dog breeders reveals the mechanisms of formation and influence of the water/river discourse on various aspects of their activities. Traditionally from antiquity and to the beginning of the 20th century during the period of fishing and nomading on boats and rafts in the warm season, the tribal groups of forest Yukagirs were isolated for a long time. This situation implied various potential dangers and risks, real and mythologized. The ancient landscape code water / river in the absence of dirt roads in the warm season and a large bog area determined the nomadic nature of the culture. The figurative and geographical model of the water universe at the locus of the water hunters and fishermen of the Upper Kolyma is captured in the discourse of spiritual and material culture as an ambivalent element. In the geo-cultural area of the descendants of the aboriginal northern nomads, the concept of the water element is traditionally built on cultural meanings, images and symbols. The appropriating nature of the economy and the longstanding significance of one of the main landscape codes of water/river stimulate the continued exsistence of ancient pagan religious and mythological representations among the forest Yukagirs in the foreseeable future

In the face of the contemporary so-called “European refugee crisis,”' the dichotomies of bodies that are naturalized into technology usage and the bodies that remain alienated from it betray the geographic, racial, and gendered discriminations that digital technologies, despite their claims at neutrality and flatness, continue to espouse. This article argues that “young electronic diasporas” (ye-diasporas) (Donà, 2014) present us with an unique view on how Europe is reimagined from below, as people stake out a living across geographies. The main premise is that young connected migrants' cross-border practices shows they ‘do family' in a way that does not align with the universal European, normative expectations of European family life. The author draws on three symptomatic accounts of young connected migrants that are variably situated geo-politically: 1) Moroccan-Dutch youth in the Netherlands; 2) stranded Somalis awaiting family reunification in Addis Ababa, Ethiopia; and, 3) working, middle, and upper-class young people of various ethnic and class backgrounds living in London. Narratives shared by members of all three groups indicate meta-categories of the ‘migrant,' ‘user,' and ‘e-diaspora' urgently need to be de-flattened. To do this de-flattening work, new links between migrant studies, feminist and postcolonial theory and digital cultures are forged. In an era of increasing digital connectivity and mobility, transnational families are far from deterritorialized – boundaries and insurmountable distances are often forcibly and painfully felt.

Abstract CancerModels.Org (www.cancermodels.org) is a research platform that standardises, harmonizes and integrates the complex and diverse data associated with Patient-Derived Cancer Models (PDCMs) for the cancer community. The portal publishes over 7500 models - covering patient-derived xenografts (PDX), organoids and cell lines - across 13 cancer types, including rare pediatric PDX models and models from minority ethnic backgrounds. A total of over 90 million data points are made available across a variety of data types, such as clinical metadata, molecular data and treatment-based information, which makes CancerModels.Org the largest free-to-consumer and open-access resource of this kind. Over the course of the last twelve months, the platform has been enhanced with new functionality and an updated user interface to cater for a more varied set of use cases. Users can now search for models of interest by exploring molecular data summaries for models of specific cancer types, as well as by using the intuitive search and faceted filtering options of the web interface. The data is also accessible via REST API, hence enabling offline analyses. The underpinning data model was augmented with additional dimensions and covers gene expression, gene mutation, copy number alteration, biomarkers, patient treatment and drug dosing studies. For an improved prioritization of PDCMs we performed knowledge enrichment by linking to external resources, such as publication platforms, cancer-specific annotation tools (COSMIC, CIViC, OncoMX, OpenCRAVAT, ClinGen), and raw data archives (ENA, EGA, GEO, dbGAP). More recently, we added immune-related features of tumors (HLA, MSI, TMB) and image data (also accessible via EMBL-EBI’s BioImage archive). Finally, to streamline model and data submission, we made available a Metadata dictionary and a Metadata validation service. Future work will focus on the curation of rare models with rich accessible metadata and data, new data visualizations, integration of new data types and resources, as well as devising a model quality rating using user feedback. These developments will maximize utility and improve reusability of models and data, and reduce barriers to model and data sharing. CancerModels.Org is deeply integrated into the general patient-derived cancer models landscape, underpinning or contributing to the data and/or software infrastructure of some of the long-running consortia, such as EUROPDX and PDXNet. The resource is freely available under an Apache 2.0 license (https://github.com/PDCMFinder). Citation Format: Zinaida Perova, Mauricio Martinez, Tushar Mandloi, Marcelo Rios Almanza, Steven Neuhauser, Dale Degley, Debra Krupke, Carol Bult, Helen Parkinson. CancerModels.org: An open global cancer research platform for patient-derived cancer models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6910.

Abstract Background and Purpose Hispanic ethnic density (HED) is associated with salubrious health outcomes for Hispanics, yet recent research suggests it may also be protective for other groups. The purpose of this study was to test whether HED was protective for other racial-ethnic groups. We tested whether social support or neighborhood social integration mediated the association between high HED and depressive symptoms (CES-D) and physical morbidity 5 years later. Lastly, we tested whether race-ethnicity moderated both main and indirect effects. Methods We used Waves 1 (2005–2006), and 2 (2010–2011) from The National Social Life, Health, and Aging Project, a national study of older U.S. adults. Our sample was restricted to Wave 1 adults who returned at Wave 2, did not move from their residence between waves, and self-identified as Hispanic, non-Hispanic White (NHW), or non-Hispanic Black (NHB; n = 1,635). We geo-coded respondents’ addresses to a census-tract and overlaid racial–ethnic population data. Moderated-mediation models using multiple imputation (to handle missingness) and bootstrapping were used to estimate indirect effects for all racial–ethnic categories. Results Depressive symptoms were lower amongst racial-ethnic minorities in ethnically (Hispanic) dense neighborhoods; this effect was not stronger in Hispanics. HED was not associated with physical morbidity. Sensitivity analyses revealed that HED was protective for cardiovascular events in all racial–ethnic groups, but not arthritis, or respiratory disease. Social support and neighborhood social integration were not mediators for the association between HED and outcomes, nor were indirect effects moderated by race–ethnicity. Conclusions This study offers some evidence that HED may be protective for some conditions in older adults; however, the phenomena underlying these effects remains a question for future work.

Abstract Background There are increasing concerns that participants in health research in the UK are not representative of the UK population, risking widening health inequities. However, detailed information on the magnitude of the problem is limited. Therefore, we evaluated if the health research conducted in the Greater Manchester region was broadly representative of its diverse population. Methods We conducted an audit of all health research studies conducted exclusively in Greater Manchester, using data from a national research network. Two researchers selected studies that were (1) an interventional or observational study of a health outcome; (2) ‘closed’ for recruitment between May 2016 and May 2021 and (3) human research. They extracted study information (dates, contacts, sample recruited, clinical speciality). Participant characteristics were sourced from published and unpublished manuscripts and requested directly from principal investigators and named study contacts. Data were extracted, summarised and compared to the Greater Manchester population for the following metrics: ethnicity, sex, age, deprivation and smoking status. A weighted mean age estimate was calculated to account for variation in age reporting. Too few studies provided patient-level deprivation data so, using the area code of the recruitment site, the area level multiple deprivation, health deprivation and disability index and decile was derived. These data were geo-mapped using QGIS 3.26. Results Overall, 145/153 (95%) studies met inclusion criteria and participant information was sourced for 85/145 (59%) studies, representing 21,797 participants. Participant information was incomplete for all metrics. Where ethnicity (N = 10,259) data were available and compared to Greater Manchester estimates there was evidence that ethnic minorities were under-represented (6% versus 16%). Most of the recruitment occurred in central Manchester (50%) and with NHS hospital settings (74%). Conclusions Greater Manchester health research in 2016–2021 was centralised and under-represented ethnic minorities. We could not report which ethnic minority group was least represented because sourcing detailed participant information was challenging. Recommendations to improve the reporting of key participant characteristics with which to monitor representativeness in health research are discussed.

Background: Nutritional research in sub-Saharan Africa has primarily focused on under-nutrition, particularly among vulnerable population subgroups such as women and children. However, there is growing evidence of an ongoing epidemiological and nutritional transition in these settings. Objective: This study aimed to examine the geographic variation of combined overweight and obesity prevalence at the state-level among women in Nigeria, while accounting for individual-level risk factors. Methods: Our analysis was based on the 2008 Nigerian Demographic and Health Survey (NDHS), including 27,967 women aged 15 and over. Individual data were collected on socio-demographic variables, but were aggregated to the 31 states. We used a Bayesian geo-additive mixed model to map the geographic distribution of overweight/obesity at the state-level, accounting for individual-level risk factors. Results: The overall prevalence of combined overweight and obesity (body mass index ≥ 25) was 20.9%. In multivariate Bayesian geo-additive models, there were several significant associations between socio-demographic variables and prevalence of overweight/obesity. Specifically, higher education [odds ratio (OR) & 95% Credible Region (CR): 1.68 (1.38, 2.00)], higher wealth index [3.45 (2.98, 4.05)], living in urban settings [1.24 (1.14, 1.36)] and increasing age were all significantly associated with a higher prevalence of overweight/obesity. There was also a striking variation in overweight/obesity prevalence across ethnic groups and state of residence, the highest being in Cross River State, in south-eastern Nigeria [2.32 (1.62, 3.40)], the lowest in Osun State in south-western Nigeria [0.48 (0.36, 0.61)]. Conclusions: This study suggests distinct geographic patterns in the prevalence of combined overweight and obesity among Nigerian women, as well as the potential role of demographic, socio-economic and environmental factors driving the ongoing nutritional transition in these settings.

Background: Although neighborhood-level socioeconomic deprivation has been associated with obesity, its relationship with diabetes, a cardio-metabolic risk factor and determinant of cardiovascular health, is poorly understood. Methods and Results: We examined the relationship between neighborhood-level socioeconomic deprivation and prevalent diabetes in the Dallas Heart Study (DHS), a multi-ethnic, population-based sample of Dallas County residents aged 18-65 (N=1621). Participants underwent detailed examination between 2000-2002. Geo-coded home addresses defined neighborhood block groups; a neighborhood-level deprivation index (NDI) for Dallas County was created using factor analysis based on 21 Census block-group characteristics (higher scores=greater neighborhood-level deprivation). Diabetes was defined by self-report, use of anti-hyperglycemic medication, or fasting glucose≥126 mg/dl. Logistic regression modeling was used to determine odds of prevalent diabetes for those in highest vs. lowest NDI tertile. In DHS, diabetes prevalence was 5%, 13%, and 16% across NDI tertiles (p<0.001). In modeling diabetes, we found a significant interaction between race and NDI (p=0.03); therefore, models were race-stratified. White, Hispanic, and black DHS participants in neighborhoods in the highest NDI tertile were up to seven times more likely to have diabetes than those living in the lowest tertile (Table). In whites and Hispanics, higher deprivation remained associated with a greater likelihood of diabetes after adjustment for age, sex, smoking, and education and was only attenuated after adjusting for income. In contrast, adjustment for confounders attenuated the relationship between NDI and diabetes among blacks. Conclusions: Residing in socioeconomically deprived neighborhoods is associated with prevalent diabetes among whites and Hispanics in DHS. These data suggest racial/ethnic disparities in cardio-metabolic risk within areas of higher socioeconomic deprivation in Dallas County.

Abstract Background Despite the significant reduction decades ago in sudden unexpected death in infancy (SUDI), decline of rates has slowed and stalled in some countries, including the USA. This led to an appreciation of ethnic variations in SUDI rates and the need to increase cultural sensitivity regarding sleep practices and circumstantial factors of SUDI. The study explored SUDI-related factors, in journal articles from two geo-cultural regions (Asian and Western countries), particularly for factors related to infant sleep practices. Methods A systematic review was conducted to identify SUDI-related factors in articles from PubMed, Scopus, and the Korean Citation Index from January 1992 to April 2019. From each article, SUDI-related factors were retrieved and categorized through the identification, aggregation, and categorization of factors into the areas of the triple risk model (TRM) of SUDI by their meanings and commonality. Significant trends in the frequency of factors were analyzed across time and between the two geo-cultural regions (Asian and Western countries) of article. Results From a review of 218 articles (38 Asian and 180 Western articles), 84 SUDI-related factors were identified: 39 factors for TRM 1, 44 factors for TRM 2, and one factor for TRM 3. Four of the top-ranked 10 factors were found in both cultural zones: sleep position, male sex, bed-sharing, and genetics. Both cultural zones identified sleep position (44.0%), bed-sharing (22.0%), and rooming-in (16.5%) as the three most important sleep-related factors for SUDI. Variations between the cultural zones were observed in the place of SUDI occurrence, overheating, swaddling or bedding standards, and smoking. Conclusions Regardless of the urgent need to identify SUDI-related factors in low-SUDI societies, Asian cultures showed a significant lack of articles on SUDI. Several sociocultural issues were recognized such as the meaning of bed-sharing and rooming-in, along with residential styles and traditional health beliefs on sleep-related SUDI factors. Particularly little attention towards smoking was found in Asian articles in terms of frequency, suggesting the need to enhance SUDI reduction strategies by incorporating gender-sensitive smoking cessation interventions. This review of SUDI factors requests child health professionals to be alert to sociocultural variations in sleep practices and SUDI factors.

Abstract Background Gan-song Yin (GSY) is originated from the scripture “Gan-song Pills”, a medical work of the Ningxia ethnic minorities, and its treatment of kidney diseases has good results. Its method of treating Renal clear cell carcinoma (KIRC) is still unknown, nevertheless. Methods Firstly, utilizing a network pharmacology strategy to screen GSY for active components and targets and looking up KIRC-related targets in GeneCards and GEO databases. Secondly, protein interaction networks were constructed and analyzed for GO and KEGG enrichment. Molecular docking was then performed and clinical and other correlations of the network pharmacology results were analyzed using bioinformatic analysis methods. Finally, we performed in vitro cellular experiments with 786-O cells and ACHN cells to validate the results of network pharmacology and bioinformatic analysis. Results With the help of network pharmacological analysis, six hub targets were eliminated. Bioinformatics study revealed that the hub targets has clinically significant clinical guiding importance. The results showed that GSY inhibited the proliferation of 786-O cells and ACHN cells, induced cell apoptosis, blocked cell cycle, and reduced cell colony formation ability. qRT-PCR results showed that GSY promoted the expression of ALB and CASP3 genes, and inhibited the expression of EGFR, JUN, MYC and VEGFA genes. Western blot results showed that GSY could promote the expression of ALB and CASP3 protein, and inhibit the expression of EGFR, JUN, MYC and VEGFA protein. Conclusions Network pharmacology and bioinformatics analysis showed that GSY could act on multiple targets through a variety of components to achieve the effect of treating KIRC. In this study, we confirmed that GSY inhibits KIRC by regulating the expression of core targets through in vitro cellular experiments, thus providing a reference for subsequent related studies.

Abstract Background T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therapies. In this study, we characterized the mutation pattern of tumor necrosis factor-alpha-inducing protein 3 (TNFAIP3) and its role in the prognosis of TCL patients. Methods Coding sequence (CDS) mutations in TNFAIP3 in TCL patients was explored using exome-sequencing data from 79 patients in our center (Guangdong Provincial People’s Hospital, GDPH) and 544 samples from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. Additionally, non-CDS mutations in TNFAIP3 in 41 TCL patients from our center (JNU) were investigated by polymerase chain reaction (PCR) and Sanger sequencing. Furthermore, non-CDS mutations in TNFAIP3 in 47 TCL patients from Gene Expression Omnibus (GEO) dataset were explored. Results In the COSMIC database, TNFAIP3 mutations in TCL patients were located in the CDS, and the overall mutation frequency was 2.2%. However, TNFAIP3 mutations were not detected in the CDS of any of the samples in our center’s datasets. Interestingly, non-CDS TNFAIP3 mutations were found in 14.6% and 4.3% of TCL patients in the JNU and GSE15842 dataset, respectively. Importantly, there was a clear trend showing that TCL patients with a TNFAIP3 mutation were associated with a longer 5-year restricted mean survival time (RMST) and favorable OS rate compared with those without a TNFAIP3 mutation in the JNU dataset [hazard ratio (HR) = 0.29, 95% confidence interval (CI) 0.07 to 1.31, P = 0.089]. Furthermore, TNFAIP3 mutations significantly correlated with T-cell large granular lymphocytic leukemia (T-LGLL) with a favorable prognosis in the JNU dataset (P = 0.002). Notably, the different mutation patterns of TNFAIP3 when comparing our center and the COSMIC datasets might be due to different ethnic and genetic backgrounds. Conclusions To the best of our knowledge, we for the first time describe that TNFAIP3 mutations in non-CDS regions are associated with favorable OS for TCL patients, which might be a potential biomarker for the prognostic stratification of Chinese TCL patients.

Introduction Australia's rich multicultural fabric is woven with the threads of diverse ethnic communities, each bringing unique cultures, languages, and traditions to the tapestry of the nation. Central to the experiences of immigrants and refugees in Australia is ethnic broadcasting, which serves as a bridge between their past and present, homeland and host country. This article delves into the multifaceted landscape of ethnic broadcasting, exploring its historical significance, current challenges, and potential pathways for future development. Historical Significance of Ethnic Broadcasting Immigrants and refugees continue to seek avenues to maintain ties with their home countries, preserve cherished memories of their origins, and find support as they adapt to life in a new environment. This need is especially pronounced for individuals who are not proficient in the primary language(s) of their host nation. Governments in countries attracting migrants recognise the importance of engaging with migrant communities to enhance their integration and bolster their contributions to national productivity. For example, the Minister for Immigration and Ethnic Affairs, M.J.R. Mackellar, noted when establishing ethnic radio in Australia that due to "a steady decline in foreign-language content on established commercial and national radio channels", and "a large increase in the non-English-speaking population in Australia", "the government ha[d] pushed ahead with ethnic radio" to provide "information, entertainment, and educational" facilities (Mackellar). Presently, the Australian Government provides annual funding to support ethnic broadcasting, which includes covering the production costs of ethnic programs for local communities, establishing new programs for specific language groups, and developing innovative projects that benefit culturally and linguistically diverse communities (Courtney). Insufficient attention has been devoted to evaluating the evolving needs and interests of various migrant communities over time (Dissanayake 113). This decline can be attributed to the satisfaction of listeners' interests through advancements in information technology and their increasing proficiency in English (Australian Bureau of Statistics), enabling them to access information from mainstream media sources. In the year 2020, there arose a pressing need to reevaluate the purposes and role of ethnic broadcasting, considering both practical and theoretical perspectives such as listeners' access to new technology to consume information, attracting volunteers, and limited financial support (Anderson et al. 57). Also, insights gained from such assessments could significantly contribute to meeting listeners' expectations, informing policy decisions in this domain, and guiding the work of content creators (Ewart 133) and also the channels in between these two ends of the spectrum, such as station managers. It is imperative to acknowledge that the role of ethnic broadcasting has evolved with broadcasting and production technology, necessitating a nuanced approach in research and creative endeavours within this sector. Furthermore, the shifting digital landscape and the widespread use of social media as a customisable platform for communication underscore the need for adaptation and innovation in ethnic broadcasting practices (Budarick). Despite its importance, ethnic community radio remains relatively understudied by researchers and academics, highlighting a gap in understanding the current dynamics of the ethnic broadcasting industry (Ewart 123). Current Challenges Facing Ethnic Broadcasting In this study, I aim to incorporate my perspective as an ethnic broadcaster to address the needs of migrants presently living in Australia. While government funding has been allocated to meet operational costs and support content development, there remains a gap in addressing the specific needs of listeners and enhancing the skills of ethnic radio presenters. Presenters of ethnic radio programs in Australia often struggle to discern the language preferences and information requirements of their audience. This challenge stems from a lack of regular communication with listeners, leaving broadcasters unaware of the issues that hold significance within their communities. To address this gap, it is essential to develop radio programs that cater to the interests and information needs of ethnic populations. These programs should cover a range of topics, including immigration matters, cultural events, council decisions, and the promotion of talents within these communities. Unlike mainstream commercial media, ethnic radio programs have the unique opportunity to focus on issues that are often overlooked but are highly relevant to ethnic audiences. Furthermore, there is a need to engage the second generation of migrants by encouraging their participation in radio programs conducted in languages they are comfortable with. This initiative not only fosters inclusivity but also ensures the preservation and transmission of cultural heritage to younger generations. Additionally, adapting program formats to align with the evolving needs and expectations of ethnic audiences is crucial for maintaining relevance and engagement. As highlighted by Tanikella, radio producers play a pivotal role in translating the needs of listeners into program formats that resonate with diasporic communities (170). By responding to the demands of their audience and reflecting locally constructed identities, media producers contribute to the representation of community identities in the public sphere. This underscores the importance of designing radio programs that are sensitive to the diverse needs and preferences of ethnic communities, thereby fostering a sense of belonging and cultural continuity. It is crucial for migrants to have access to information about available facilities, their rights, and opportunities for settling in their new country. Research into ethnic media in Australia highlights its significant role in connecting migrants to transnational networks, preserving cultures and languages, navigating new identities and communities, and facilitating adjustment to life in Australia (Hopkins, qtd. in Budarick). The growth of ethnic radio programs in Australia has been notable since its inception in 1975. Presently, the Australian community radio sector produces a substantial amount of ethnic radio content, with over 2,070 hours broadcast weekly in more than 110 languages across 80 radio stations, including six full-time ethnic stations. This vast array of programming engages over 4,000 volunteers from 125 cultural and ethnic groups (NEMBC). However, to ensure the effective support of ethnic minorities in Australia through broadcast radio, financial backing is essential. Community radio stations rely heavily on volunteers, with over 22,000 individuals contributing their time to these stations across Australia. Despite the significant volunteer effort, paid full-time equivalent staff employed by community radio stations numbered 900 in 2023 (Treasury). In recognition of the importance of ethnic media in supporting minority communities, the Australian Federal Government, through the Community Broadcasting Foundation (CBF), allocated $4.18 million from Federal Budget 2022-23 for ethnic content development purposes (CBAA, "Federal Budget 2022-23"). Additionally, various state governments continue to provide funding for ethnic radio programs through relevant agencies (Letch 18). Despite government support at both federal and state levels, the number of ethnic radio programs remain the same serving the relevant ethnic groups. However, this article suggests the need for restructuring within the ethnic broadcasting sector, particularly in content development, to better meet the diverse needs of ethnic audiences. Ethnic Radio Programs Characteristics of ethnic radio programs are multifaceted and influenced by the unique nature of the medium as well as the diverse preferences and behaviours of their listeners. Firstly, radio as a medium engages the sense of hearing, prompting listeners to visualise and imagine based on auditory stimuli. This concept, as articulated by Smythe (qtd. in Beck), underscores the importance of creating vivid "audio pictures" for listeners, especially in ethnic radio where individuals often seek to evoke nostalgic memories of their homeland. Ethnic radio programs serve as a conduit for migrants to reconnect with their cultural roots, offering aural representations of familiar sounds and languages in the absence of electronic communication resources. Additionally, Gary Ferrington distinguishes between hearing and listening, highlighting that while hearing is a physiological process, listening involves the psychological attribution of meaning to auditory input (61-7). This differentiation is pertinent in understanding how radio audiences interact with and interpret program content. Audience engagement with ethnic radio programs can be categorised into active and passive listenership. Active listeners demonstrate a high level of involvement with specific programs, frequently engaging through calls, messages, and interactions with presenters. In contrast, passive listeners tune in intermittently and may not exhibit loyalty to any station or program (Padmakumar 614). Ethnic program listeners tend to lean towards active engagement due to the limited frequency of broadcasts and their desire to stay connected with their cultural community. They often approach radio listening with echoic memories of music and language from their homeland, seeking familiarity and emotional resonance in the programming. For instance, some listeners may prefer original versions of songs from their country, even if they are no longer popular locally (Anderson et al. 21). Moreover, active ethnic radio listeners play an integral role in shaping program content and community engagement. They provide feedback, request songs, share information, participate in fundraising events like radiothons, and even express interest in becoming presenters themselves. This active involvement reflects a deeper sense of connection and ownership within the ethnic radio community (Anderson et al. 36). Conversely, passive listeners may view radio primarily as background music, enjoying the ambience without actively engaging with specific content. Their interaction with the medium is more incidental, often occurring while multitasking or attending to other activities. Overall, the characteristics of ethnic radio programs are shaped by the interplay between the medium's auditory nature, the preferences of diverse listeners, and the cultural significance of maintaining connections to one's heritage. Active engagement, nostalgic resonance, and community involvement are central themes that distinguish ethnic radio programming in its ability to cater to the needs and interests of migrant communities. To navigate the development of the technology and the challenges related to changes in the listenership, ethnic broadcasters must embrace innovative strategies that cater to the evolving needs of their audiences. One approach involves redefining the role of ethnic radio programs to encompass a broader range of topics, including immigration matters, cultural events, and community news. By diversifying content and engaging with listeners' interests, broadcasters can enhance the relevance and appeal of their programs in the digital age. Empowering Ethnic Radio Presenters Ethnic radio program presenters play a crucial role in delivering culturally relevant content and facilitating community engagement. However, recruiting skilled presenters poses challenges, particularly when specific language requirements must be met. Therefore, it is suggested, language fluency should not deter younger people from becoming involved in the sector, and youth ethnic programming in English, or a mixture of languages, should be supported (Anderson et al. 47). Kalinga Seneviratne, a former ethnic radio presenter turned academic, attests to the pivotal role of community radio in fostering broadcasting careers for migrants in Australia (11): “if not for (ethnic) community radio, I have no doubt that I would never have become a broadcaster in Australia”. There are many examples that can be given. Encouraging second-generation migrants to participate as presenters and listeners is vital for sustaining ethnic radio audiences. Surveys suggest that allocating more airtime to music could attract younger listeners, but the language preference for music content remains ambiguous (Anderson). Addressing the relevance of ethnic media for the next generation is a pressing concern, given their evolving cultural identities and media consumption habits (Papoutsaki et al. 23). However, engaging second-generation migrants poses challenges, as older community members often serve as cultural gatekeepers and are hesitant to relinquish control over language and content (Australian House of Representatives). Additionally, community radio stations can only offer limited technical training, focussing on basic broadcasting skills due to resource constraints (Cohen 1016). Training programs provided by stations like 3ZZZ, 3CR, and 3MBS cover fundamental broadcasting knowledge but may not adequately prepare presenters for professional standards (3ZZZ). Effective broadcasting requires mastery of technical operations, vocal delivery, language proficiency, and community knowledge (Beaman 43; Fleming 6-7). Acquiring essential skills enables individuals to effectively communicate through radio, aiding new and emerging communities in their transition. The Community Media Training Organisation (CMTO) could address this need by developing a new pathway course tailored to ethnic listenership, as existing training programs such as Presentation, Advanced Presentation, Audio Editing, Copywriting for Sponsorship, Creating Social Media Content, Music Interviewing, etc. (CMTO) are primarily focussed on general program presentation at community radio stations. To compete with mainstream radio, ethnic broadcasters must prioritise professionalism and engaging presentation styles to attract and retain listeners (Wolfenden 5-21). Ultimately, the success of ethnic radio hinges on the ability of presenters to bridge cultural divides, cater to diverse audience needs, and maintain high-quality programming standards. As Australia continues to welcome new waves of migrants and refugees, there is a pressing need to support their settlement process and integration into society. Ethnic radio programs play a crucial role in providing information, language support, and community connections for recently arrived migrants. By updating program formats and language groups to reflect changing demographics, broadcasters can ensure that their programs remain relevant and accessible to all members of the community. Public Service Broadcasting and New Media Public service broadcasting in Australia encompasses entities like the Australian Broadcasting Corporation (ABC) and the Special Broadcasting Service (SBS), which are funded by the government but operate independently in terms of programming decisions. These broadcasters are tasked with promoting national identity, as well as informing and entertaining audiences (Lobato & Meese 121; Cinque 11-16). The ABC, operating under a statute and receiving public funds, is expected to adhere to standards of objective journalism, distinct from commercial media driven by private interests (Finkelstein). On the other hand, SBS radio programs are tailored to language groups rather than nationalities, allowing for diverse listenership across cultures (Department of Infrastructure, Transport, Regional Development, Communications). Programs cater to various community needs, including news, current affairs, arts, culture, and sports (ibid.). Public service broadcasting in Australia differs from community broadcasting in several aspects, including licencing, ownership, operational structure, and funding policies. While national broadcasters like the ABC and SBS receive indirect government funding, community broadcasters operate as not-for-profit entities with community ownership structures. Community broadcasters are further distinguished by their obligation to broadcast local content and to represent the community they serve (CBAA). The landscape of ethnic media in Australia now faces competition from emerging digital platforms, spanning radio, television, and streaming services accessible via smartphones and computers. The next section will explore the impact of these alternative media forms on migrants' lives in Australia. Embracing New Technologies Community broadcasting has historically faced limitations in content development. However, it can be argued that community radio is where innovative content and radical programming thrive, without facing the limitations imposed by commercial interests, industry guidelines (ACMA), and broadcasting technology. Community radio primarily caters to audiences via AM/FM radio sets and digital devices. Digital convergence has transformed broadcasting, necessitating a diverse range of technology, personnel, and management skills in today's multi-platform media environment (CBAA). Presently, listeners access radio programs through various channels, including live streaming from radio stations, mobile apps like TuneIn, personal assistant apps such as Google Home and Amazon Alexa, and even television. The availability of archived content on the Internet further enhances accessibility for listeners, a feature not present in traditional radio broadcasting. Audio content producers have embraced alternative publishing methods beyond traditional FM and AM frequencies, including Internet radio, MP3 players, podcasts, and streaming services like Spotify. However, the digital transformation of radio broadcasting raises questions about the medium's nature and mode of delivery, as highlighted by scholars like Dubber and Lacey (Berry). Online streaming allows radio stations to reach audiences beyond their geographic boundaries, offering a more diverse listener base (Jackson Pitts & Harms 274). Internet radio, characterised by live or scheduled audio (and sometimes video) streaming over Internet Protocol (IP), can be accessed via computers and mobile phones with 4G or 5G data connection. Unlike conventional radio, listeners cannot request songs or participate in talkback shows, but they enjoy the flexibility of selecting content according to their preferences. Compared to terrestrial radio stations, Internet radio is cost-effective, requiring minimal infrastructure and often operating from home-based studios (Berry 7-22). Therefore, Internet radio is growing every day and mobile devices are going to play a very important part in the future of radio. According to the Australian Communications and Media Authority, Australians are listening to more audio delivered over the internet in 2022–23 compared to the previous year (ACMA). Moreover, ethnic media, including social media platforms, play a significant role in fostering social bonds among elderly individuals (Du et al.). Ethnic groups utilise various social media apps to create closed groups, share community-related information, and maintain cultural connections. For instance, platforms like Facebook, WhatsApp, and Viber host private groups like 'Aussie Connect', catering to specific ethnic communities in Australia. In summary, conventional radio listeners are transitioning to novel audio listening technologies that offer personalised content experiences. Therefore, this article suggests developing new formats for ethnic radio programs, considering essential factors such as audience preferences, content guidelines, and leveraging available technology for listener benefit. Conclusion In conclusion, ethnic broadcasting in Australia stands at a crossroads, facing both challenges and opportunities in the evolving media landscape. By addressing the changing needs of diverse ethnic communities, empowering presenters, and embracing new technologies, broadcasters can continue to serve as a vital resource for migrants and refugees. Through collaboration, innovation, and a commitment to cultural preservation, ethnic broadcasting can chart a course towards a more inclusive and connected future for all Australians. References 3ZZZ. "Volunteer and Training." 2024. <https://www.3zzz.com.au/event/3zzz-broadcaster-training-course/>. Australian Communications and Media Authority (ACMA). "Communications and Media in Australia: Trends and Developments in Viewing and Listening 2022–23." 2023. <https://www.acma.gov.au/publications/2023-12/report/communications-and-media-australia-trends-and-developments-viewing-and-listening-2022-23>. ———. "Community Broadcasting Participation Guidelines." 2010. <https://www.acma.gov.au/publications/2010-06/guide/community-broadcasting-participation-guidelines>. Anderson, Heather, et al. "Connecting Communities in a Digital Media Era: Australian Ethnic Community Broadcasting in the 21st Century." Griffith University, 2023. <http://hdl.handle.net/10072/429259>. Anderson, R. "NEMBC Membership Survey Results." The Ethnic Broadcaster. Abbotsford, Vic.: NEMBC, 2013. Australian Bureau of Statistics. "Permanent Migrants in Australia." 2021. <https://www.abs.gov.au/statistics/people/people-and-communities/permanent-migrants-australia/latest-release>. Australian House of Representatives. Submission 108. 2006. <https://www.aph.gov.au/parliamentary_business/committees/house_of_representatives_committees?url=cita/community_broadcasting/subs/sub108.pdf>. Beaman, J. Programme Making for Radio. London: Routledge, 2006. Beck, A. "Is Radio Blind or Invisible? A Call for a Wider Debate on Listening-In." 1999. <https://www.dmd27.org/cog.html>. Berry, R. "Podcasting: Considering the Evolution of the Medium and Its Association with the Word ‘Radio’." Radio Journal: International Studies in Broadcast & Audio Media 14 (2016): 7-22. Budarick, J. "Ethnic Media and Migrant Settlement." Global Media Journal (2020). <https://www.hca.westernsydney.edu.au/gmjau/wp-content/uploads/2020/10/GMJAU-Ethnic-media-and-migrant-settlement.pdf>. Community Broadcasting Association of Australia (CBAA). Community Radio Broadcasting Codes of Practice. 2018. <http://www.cbaa.org.au/sites/default/files/media/Community%20 Radio%20Broadcasting%20Codes%20of%20Practice%202008.pdf>. ———. "Federal Budget 2022-23." 25 Oct. 2022. <https://www.cbaa.org.au/article/federal-budget-2022-23>. ———. Voices & Vision Community Broadcasting in Australia. 2010. <https://www.cbaa.org.au>. Cinque, T. Subtext: Are We Really Just Mass Media Sponges? Oxford: Oxford UP, 2012. Cohen, E. "‘We are staying in our Country—here’: Israeli Mediascapes in Melbourne." Journal of Ethnic and Migration Studies 34 (2008): 1016. Community Media Training Organisation. 2024. <https://cmto.org.au/media-training/pathways-courses/>. Courtney, Chantelle. “Explainer: What Is Ethnic Funding?” CBF, 28 Mar. 2023, <https://cbf.org.au/explainer-what-is-ethnic-funding/>. Department of Infrastructure, Transport, Regional Development, Communications and the Arts. 2023. <https://www.infrastructure.gov.au/media-technology-communications/radio/abc-sbs-radio>. Dissanayake, C. "Tuning the Migrant Voices: A Study of Sinhala Language Ethnic Radio Programs in Melbourne." Master’s thesis. Melbourne: Deakin University, 2014. <https://hdl.handle.net/10536/DRO/DU:30067407>. Du, J.T., Tan, Y., & Xu, F. "The Information Context of Elderly Chinese Immigrants in South Australia: A Preliminary Investigation." Information Research 24.1 (2019). <http://www.informationr.net/ir//24-1/isic2018/isic1820.html>. Ewart, J. "Exploring the Unity in Australian Community Radio." Media International Australia 142 (2012): 123-134. Ferrington, G. "Audio Design: Creating Multi-Sensory Images for the Mind." Journal of Visual Literacy 14.1 (1994): 61-67. Finkelstein, R. "The Report of the Independent Inquiry into the Media and Media Regulation." Report to the Minister for Broadband, Communications and the Digital Economy, 28 Feb. 2012. Canberra: Commonwealth of Australia, 2012. <https://webarchive.nla.gov.au/awa/20120320233242/http://pandora.nla.gov.au/pan/132662/20120321-1002/www.dbcde.gov.au/digital_economy/independent_media_inquiry.html>. Fleming, C. The Radio Handbook. London: Routledge, 2009. Jackson Pitts, M., and R. Harms. "Radio Websites as a Promotional Tool." Journal of Radio Studies 10 (2003): 274. Letch, K. "Review of Content Development Funding." Melbourne: Community Broadcasting Foundation, 2014. Lobato, R., and J. Meese. "Australia: Circumvention Goes Mainstream." In Geo-blocking and Global Video Culture. Amsterdam: Institute of Network Cultures, 2016. 120-128. Mackellar, M.J.R. "Ethnic Radio Will Benefit Both Migrants and Australians." Press release. 1977. <http://www.multiculturalaustralia.edu.au/doc/mackellar_1.pdf>. National Ethnic and Multicultural Broadcasters Council (NEMBC). "Ethnic Community Broadcasting: Strengthening Social Cohesion and Citizenship—Pre-Budget Submission 2024-25." 2023. <https://www.nembc.org.au/wp-content/uploads/2024/03/NEMBC-Federal-Pre-Budget-Submission-2024-25.pdf>. Padmakumar, K. "Understanding the Passive Listeners of FM Radio Stations in South India." Online Journal of Communication and Media Technologies 5 (2015): 614. <https://www.ojcmt.net/article/understanding-the-passive-listeners-of-fm-radio-stations-in-south-india-5682>. Papoutsaki, E., E. Kolesova, and L. Stephenson. "Curated Proceedings of the Ethnic Migrant Media Forum 2014: Are We Reaching All New Zealanders? Exploring the Role, Benefits, Challenges & Potential of Ethnic Media in New Zealand." Auckland: Unitec ePress, 2017. <https://www.unitec.ac.nz/epress/wp-content/uploads/2017/03/ethnic-migrant-media-forum-2014_curated-proceedings>. Seneviratne, K. "Giving a Voice to the Voiceless: Community Radio in Australia." Media Asia 20 (1993): 11. Tanikella, L. "Voices from Home and Abroad: New York City's Indo-Caribbean Media." International Journal of Cultural Studies 12.2 (2009): 170. Treasury. "Community Broadcasting Matters to Australia’s Wellbeing and Progress." 2023. <https://treasury.gov.au/sites/default/files/2023-03/c2023-379612-community_broadcasting_association_of_australia.pdf>. Wolfenden, H. "‘I know exactly who they are’: Radio Presenters’ Conceptions of Audience." Radio Journal: International Studies in Broadcast & Audio Media 12 (2014): 5-21.

Abstract Background Rheumatoid arthritis (RA) occurs across the globe in different ethnic populations. Most RA patients harbor anti-modified protein antibodies (AMPA); however, it is unclear whether differences exist in autoantibody responses at different geographic locations and between different ethnic groups, which could provide new clues regarding factors underlying autoantibody development. We therefore investigated AMPA prevalence and association with HLA DRB1 alleles and smoking in four ethnically diverse populations on four different continents. Methods Anti-carbamylated (anti-CarP), anti-malondialdehyde acetaldehyde (anti-MAA), and anti-acetylated protein antibodies (anti-AcVim) IgG were determined in anti-citrullinated protein antibody-positive Dutch (NL, n = 103), Japanese (JP, n = 174), First Nations Peoples in Canada (FN, n = 100), and black South African (SA, n = 67) RA patients. Ethnicity-matched local healthy controls were used to calculate cut-offs. Risk factors associated with AMPA seropositivity in each cohort were identified using logistic regression. Results Median AMPA levels were higher in First Nations Peoples in Canada and especially South African patients, as reflected by percentage seropositivity: NL, JP, FN, and SA: anti-CarP: 47%, 43%, 58%, and 76% (p < 0.001); anti-MAA: 29%, 22%, 29%, and 53% (p < 0.001); and anti-AcVim: 20%, 17%, 38%, and 28% (p < 0.001). Total IgG levels also differed markedly, and when autoantibody levels were normalized to total IgG, differences between cohorts became less pronounced. Although there were some associations with AMPA and HLA risk alleles and smoking, none was consistent across all four cohorts. Conclusions AMPA against various post-translational modifications could consistently be detected on different continents across ethnically diverse RA populations. Differences in AMPA levels corresponded to differences in total serum IgG levels. This suggests that, despite differences in risk factors, a common pathway may be involved in AMPA development across geographic locations and ethnicities.