Academic literature on the topic 'Genomic screens'
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Journal articles on the topic "Genomic screens"
Gaillochet, Christophe, Ward Develtere, and Thomas B. Jacobs. "CRISPR screens in plants: approaches, guidelines, and future prospects." Plant Cell 33, no. 4 (April 1, 2021): 794–813. http://dx.doi.org/10.1093/plcell/koab099.
Full textRorth, P., K. Szabo, A. Bailey, T. Laverty, J. Rehm, G. M. Rubin, K. Weigmann, et al. "Systematic gain-of-function genetics in Drosophila." Development 125, no. 6 (March 15, 1998): 1049–57. http://dx.doi.org/10.1242/dev.125.6.1049.
Full textSheel, Ankur, and Wen Xue. "Genomic Amplifications Cause False Positives in CRISPR Screens." Cancer Discovery 6, no. 8 (August 2016): 824–26. http://dx.doi.org/10.1158/2159-8290.cd-16-0665.
Full textHart, Traver, Kevin R. Brown, Fabrice Sircoulomb, Robert Rottapel, and Jason Moffat. "Measuring error rates in genomic perturbation screens: gold standards for human functional genomics." Molecular Systems Biology 10, no. 7 (July 2014): 733. http://dx.doi.org/10.15252/msb.20145216.
Full textSalamon, Hugh, Midori Kato-Maeda, Peter M. Small, Jorg Drenkow, and Thomas R. Gingeras. "Detection of Deleted Genomic DNA Using a Semiautomated Computational Analysis of GeneChip Data." Genome Research 10, no. 12 (November 21, 2000): 2044–54. http://dx.doi.org/10.1101/gr.152900.
Full textJilderda, Laura J., Lin Zhou, and Floris Foijer. "Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer." Cells 10, no. 2 (February 6, 2021): 342. http://dx.doi.org/10.3390/cells10020342.
Full textThe Transatlantic Multiple Sclerosis Genetics Cooperative. "A meta-analysis of genomic screens in multiple sclerosis." Multiple Sclerosis 7, no. 1 (February 1, 2001): 3–11. http://dx.doi.org/10.1191/135245801669625359.
Full textXU, AXIANG, and SHENGKUN SUN. "Genomic profiling screens small molecules of metastatic prostate carcinoma." Oncology Letters 10, no. 3 (July 8, 2015): 1402–8. http://dx.doi.org/10.3892/ol.2015.3472.
Full textAshoti, Ator, Francesco Limone, Melissa van Kranenburg, Anna Alemany, Mirna Baak, Judith Vivié, Frederica Piccioni, et al. "Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen." PLOS ONE 17, no. 2 (February 17, 2022): e0263262. http://dx.doi.org/10.1371/journal.pone.0263262.
Full textKaplow, Irene M., Rohit Singh, Adam Friedman, Chris Bakal, Norbert Perrimon, and Bonnie Berger. "RNAiCut: automated detection of significant genes from functional genomic screens." Nature Methods 6, no. 7 (July 2009): 476–77. http://dx.doi.org/10.1038/nmeth0709-476.
Full textDissertations / Theses on the topic "Genomic screens"
Wilson, Jennifer L. (Jennifer Lynn). "Network analyses for functional genomic screens in cancer." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104236.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (pages 128-151).
Gene interference screens are a widely adopted and popular tool for uncovering gene function but imperfections in the technology limit the power of these investigations. There are many completed and on-going RNAi investigations across a multitude of biological systems because these experiments are scalable, cost-effective, and relatively easily adapted to multiple experimental environments. The most influential disadvantage is that many of the individual reagents are non-specific and interfere with genes other than the intended target. Efforts to improve limitations in RNAi have focused on statistical models and improving reagents, yet have not explored using biological context to select gene targets. This thesis uses network modeling and data integration to provide context for gene interference studies, and demonstrates the utility of this approach in two systems: Acute Lymphoblastic Leukemia (ALL) is a disease of undifferentiated B-cells that results from accumulation of genetic lesions, yet we have an incomplete understanding of all genes contributing to the disease and how they interact. To discover genetic mediators of this disease, we employ a genome-scale shRNA screen, and complement this data with differential mRNA expression and ChIP-seq data using network integration. The integrated model identifies processes not represented in any input set and predicts novel genes contributing to disease. We specifically validate the role of Wwpl as a tumor suppressor in ALL. Aberrant growth factor pathway activity drives cancer pathology and is the target of molecular cancer therapies. Specifically, the epidermal growth factor receptor (EFGR) pathway and its ligand, transforming growth factor alpha (TGF[alpha]) are clinically relevant to gastric cancer. We use an shRNA screen and Prize Collecting Steiner Forest (PCSF) algorithm to discover the pathway regulating TGF shedding. This pathway identifies common regulators of TGF[alpha] shedding and NF[chi]B regulation, yet targeting NF[chi]B and the EGFR pathway has thus far been unsuccessful in cancer therapies. Our network identifies IRAK1 as a viable path forward for modulating both TGF[alpha] and NF[chi]B in gastric cancer.
by Jennifer L. Wilson.
Ph. D.
Burrows, Anna. "Genome-Wide Loss-of-Function Genetic Screens Identify Novel Senescence Genes and Putative Tumor Suppressors." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10191.
Full textPickering, H. "Identification of Chlamydia trachomatis immune targets through immunological and population-genomic screens and elucidation of potential roles in bacterial pathogenesis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/3928322/.
Full textAllan, Kristina Jean. "Enhancing Oncolytic Virotherapy Using Functional Genomic Screening." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37910.
Full textLi, Shuzhao. "A genomic screen for Zic1 target genes in neural development." Thesis, Montana State University, 2006. http://etd.lib.montana.edu/etd/2006/li/LiS0806.pdf.
Full textPedro, Rodrigues Joana Cristina. "Yeast genome-wide telomere screens and insights into cancer." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3898.
Full textGiedraitis, Vilmantas. "Candidate gene analyses and genome-wide screens in multiple sclerosis /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-408-9/.
Full textSawcer, Stephen James. "A linkage genome screen in multiple sclerosis." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627121.
Full textJarvis, Morgan L. "Development of a novel screen protocol for the identification of genes causing replication associated genomic instability in Schizosaccharomyces pombe." Thesis, Kingston, Ont. : [s.n.], 2008. http://hdl.handle.net/1974/1227.
Full textDeligiannaki, Myrto. "Identification of novel septate junction components through genome-wide glial screens." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-183079.
Full textBooks on the topic "Genomic screens"
Edmonds, Dawn Elaine. A genome-wide screen in Saccharomyces cerevisiae to identify novel genes that interact with telomerase. 2006.
Find full textBook chapters on the topic "Genomic screens"
Pucci, Michael J., John F. Barrett, and Thomas J. Dougherty. "Bacterial “Genes-to-Screens” in the Post-Genomic Era." In Pathogen Genomics, 83–96. Totowa, NJ: Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_7.
Full textAdikari, Samantha, Elizabeth Hong-Geller, and Sofiya Micheva-Viteva. "Methods for Enrichment of Bacterial Persister Populations for Phenotypic Screens and Genomic Studies." In Methods in Molecular Biology, 71–82. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1621-5_5.
Full textMcDonald, Sherin, Arunkumar Annan Sudarsan, Hanan Babeker, Kiranmayee Budharaju, and Maruti Uppalapati. "Generation of Protein Inhibitors for Validation of Cancer Drug Targets Identified in Functional Genomic Screens." In Methods in Molecular Biology, 307–31. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1740-3_17.
Full textParo, Renato, Ueli Grossniklaus, Raffaella Santoro, and Anton Wutz. "RNA-Based Mechanisms of Gene Silencing." In Introduction to Epigenetics, 117–33. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68670-3_6.
Full textChini, Andrea. "Application of Yeast-Two Hybrid Assay to Chemical Genomic Screens: A High-Throughput System to Identify Novel Molecules Modulating Plant Hormone Receptor Complexes." In Methods in Molecular Biology, 35–43. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-592-7_4.
Full textJavid, Babak, and Eric J. Rubin. "Whole Genome Screens in Macrophages." In Phagocyte-Pathogen Interactions, 537–43. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555816650.ch35.
Full textSanjana, Neville E. "Multiscale Genome Engineering: Genome-Wide Screens and Targeted Approaches." In Research and Perspectives in Neurosciences, 83–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60192-2_8.
Full textDesler, Claus, Jon Ambæk Durhuus, and Lene Juel Rasmussen. "Genome-Wide Screens for Expressed Hypothetical Proteins." In Methods in Molecular Biology, 25–38. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-424-7_3.
Full textLiao, Xihao, Xin-Hui Xing, and Chong Zhang. "New Method for Genome-Scale Functional Genomic Study in Bacteria with Superior Performance: CRISPR Interference Screen." In Methods in Molecular Biology, 123–41. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1720-5_7.
Full textYau, Edwin H., and Tariq M. Rana. "Next-Generation Sequencing of Genome-Wide CRISPR Screens." In Methods in Molecular Biology, 203–16. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7514-3_13.
Full textConference papers on the topic "Genomic screens"
Marcotte, Richard, Kevin Brown, Azin Sayad, Maliha Haider, Troy Ketela, Jason Moffat, and Benjamin G. Neel. "Abstract 5084: Functional genomic classification of breast cancer using pooled lentivirus shRNA screens." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5084.
Full textInoue, Akira, Bahar Salimian Rizi, Alessandro Carugo, Sahil Seth, Christopher Bristow, Giannicola Genovese, Andrea Viale, David G. Menter, Scott Kopetz, and Giulio F. Draetta. "Abstract 414: Identifying selective vulnerabilities in colorectal cancer molecular subtypes usingin vivofunctional genomic screens." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-414.
Full textKim, Suntae, Patrick J. Grohar, Carleen Klumpp, Ashish Lal, Scott E. Martin, Lee J. Helman, and Natasha J. Caplen. "Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-520.
Full textStover, Elizabeth H., Maria B. Baco, Ofir Cohen, Yvonne Li, Elizabeth Christie, Mukta Bagul, Amy Goodale, et al. "Abstract AP14: POOLED GENOMIC SCREENS IDENTIFY ANTI-APOPTOTIC GENES AS MEDIATORS OF CHEMOTHERAPY RESISTANCE IN OVARIAN CANCER." In Abstracts: 12th Biennial Ovarian Cancer Research Symposium; September 13-15, 2018; Seattle, Washington. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1557-3265.ovcasymp18-ap14.
Full textMaxson, Julia, Jason Gotlib, Daniel Pollyea, Angela Fleischman, Christopher Eide, Daniel Bottomly, Beth Wilmot, et al. "Abstract 2282: Rapid identification of targetable CSF3R mutations that define neutrophilic leukemia by combining functional and genomic screens." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2282.
Full textCasas, Matias. "Abstract 5135: Functional genomic shRNA screens reveal that the canonical Wnt pathway protects lung cancer cells from EGFR inhibition." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5135.
Full textGarcia, Felix Sanchez, Patricia Villagrasa, Junji Matsui, Bo-Juen Chen, Dylan Kotliar, Veronica Castro, Jose M. Silva, and Dana Pe'er. "Abstract 3168: Helios identifies novel oncogenes in breast cancer by integrating genomic characterization of primary tumors and functional shRNA-screens." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3168.
Full textFrank, An, Sujatha Kumar, Christina Ghirelli, Kim Hoenderdos, Tabasum Huseni, Lauren Thibault, Lydia Kifle, et al. "Abstract B66: An integrated immuno-oncology platform using high-throughput cell based assays, gene editing and genomic screens in immune cells." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; October 20-23, 2016; Boston, MA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/2326-6074.tumimm16-b66.
Full textMunoz, Diana, Frank P. Stegmeier, and Michael Schlabach. "Abstract B21: CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions." In Abstracts: AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; January 4-7, 2017; San Diego, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-8514.synthleth-b21.
Full textMeyers, Robin M., Andrew J. Aguirre, Barbara A. Weir, Francisca Vazquez, Cheng-Zhong Zhang, Uri Ben-David, April Cook, et al. "Abstract B39: Genomic copy number alterations introduce a gene-independent viability bias in CRISPR-Cas9 knock-out screens of cancer cell lines." In Abstracts: AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.pmccavuln16-b39.
Full textReports on the topic "Genomic screens"
Perrimon, Norbert. Parallel Genomic and Chemical Screens to Identify Both Therapeutic Targets and Inhibitors of These Targets in the Treatment of Neurofibromatosis. Fort Belvoir, VA: Defense Technical Information Center, December 2006. http://dx.doi.org/10.21236/ada465264.
Full textSadot, Einat, Christopher Staiger, and Zvi Kam Weizmann. functional genomic screen for new plant cytoskeletal proteins and the determination of their role in actin mediated functions and guard cells regulation. United States Department of Agriculture, January 2003. http://dx.doi.org/10.32747/2003.7587725.bard.
Full textWeil, Clifford F., Anne B. Britt, and Avraham Levy. Nonhomologous DNA End-Joining in Plants: Genes and Mechanisms. United States Department of Agriculture, July 2001. http://dx.doi.org/10.32747/2001.7585194.bard.
Full textAvni, Adi, and Kirankumar S. Mysore. Functional Genomics Approach to Identify Signaling Components Involved in Defense Responses Induced by the Ethylene Inducing Xyalanase Elicitor. United States Department of Agriculture, December 2009. http://dx.doi.org/10.32747/2009.7697100.bard.
Full textSela, Hanan, Eduard Akhunov, and Brian J. Steffenson. Population genomics, linkage disequilibrium and association mapping of stripe rust resistance genes in wild emmer wheat, Triticum turgidum ssp. dicoccoides. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598170.bard.
Full textOstersetzer-Biran, Oren, and Alice Barkan. Nuclear Encoded RNA Splicing Factors in Plant Mitochondria. United States Department of Agriculture, February 2009. http://dx.doi.org/10.32747/2009.7592111.bard.
Full textHeifetz, Yael, and Michael Bender. Success and failure in insect fertilization and reproduction - the role of the female accessory glands. United States Department of Agriculture, December 2006. http://dx.doi.org/10.32747/2006.7695586.bard.
Full textGlazer, Itamar, Alice Churchill, Galina Gindin, and Michael Samish. Genomic and Organismal Studies to Elucidate the Mechanisms of Infectivity of Entomopathogenic Fungi to Ticks. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7593382.bard.
Full textPerl-Treves, Rafael, M. Kyle, and Esra Galun. Development and Application of a Molecular Genetic Map for Melon (Cucumis melo). United States Department of Agriculture, October 1993. http://dx.doi.org/10.32747/1993.7568094.bard.
Full textCytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598174.bard.
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