Dissertations / Theses on the topic 'Genomic comparisons'
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Bradwell, Katie. "Genomic comparisons and genome architecture of divergent Trypanosoma species." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4598.
Full textLi, Alice Hoy Lam. "Identification of virulence determinants of Mycobacterium tuberculosis via genetic comparisons of a virulent and an attenuated strain of Mycobacterium tuberculosis." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/596.
Full textBatzoglou, Serafim. "Computational genomics : mapping, comparison, and annotation of genomes." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/8629.
Full textIncludes bibliographical references (leaves 180-191).
The field of genomics provides many challenges to computer scientists and mathematicians. The area of computational genomics has been expanding recently, and the timely application of computer science in this field is proving to be an essential component of the large international effort in genomics. In this thesis we address key issues in the different stages of genome research: planning of a genome sequencing project, obtaining and assembling sequence information, and ultimately study, cross-species comparison, and annotation of finished genomic sequence. We present applications of computational techniques to the above areas: (1) In relation to the early stages of a genome project, we address physical mapping, and we present results on the theoretical problem of finding minimum superstrings of hypergraphs, a combinatorial problem motivated by physical mapping. We also present a statistical and simulation study of "walking with clone-end sequences", an important method for sequencing a large genome.
(cont.) (2) Turning to the problem of obtaining the finished genomic sequence, we present ARACHNE, a prototype software system for assembling sequence data that are derived from sequencing a genome with the "shotgun" method. (3) Finally, we turn to the computational analysis of finished genomic sequence. We present GLASS, a software system for obtaining global pairwise alignments of orthologous finished sequences. We finally use GLASS to perform a comparative structure and sequence analysis of orthologous human and mouse genomic regions, and develop ROSETTA, the first cross-species comparison-based system for the prediction of protein coding regions in genomic sequences.
by Serafin Batzoglou.
Ph.D.
Dousseaud, Peggy Marie Madeleine. "A comparative genomic analysis of hydrocarbon synthesis in Desulfovibrio sp." Thesis, University of Exeter, 2018. http://hdl.handle.net/10871/34379.
Full textJain, Gaurav. "Genomic comparison of species based on metabolic pathway components." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 61 p, 2008. http://proquest.umi.com/pqdweb?did=1605156451&sid=3&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Full textPrincipal faculty advisors: Li Liao, Dept. of Computer & Information Sciences and E. Fidelma Boyd, Dept. of Biological Sciences. Includes bibliographical references.
Sharma, Ruchira. "Isolation, Characterization, and Genomic Comparison of Bacteriophages of Enterobacteriales Order." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8577.
Full textDong, Xin. "Comparative genomics of rickettsia species." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5054/document.
Full textThe Rickettsia genus is composed of small, Gram-negative, bacteria that are obligate intracellular eukaryotic symbionts. Members of the genus Rickettsia are best known for infecting and causing severe diseases in humans and other animals. To date, 26 valid Rickettsia species have been identified worldwide, including 20 that are proven pathogens. All validated Rickettsia species are associated to arthropods that act as vectors and/or reservoirs. The phylogenies based on various molecular markers have resulted in discrepant topologies, with R. bellii and R. canadensis being classified neither among spotted fever nor typhus group rickettsiae. In this thesis, using the advanced whole genomic sequencing methods, we have and analyzed the genomic sequences from four Rickettsia species, including R. helvetica, R. honei, R. australis and R. japonica. Phylogenomics constitute a new strategy to better understand their evolution. These microorganisms underwent a reductive genomic evolution during their specialization to their intracellular lifestyle. Several evolutive characteristics, such as gene rearrangement, reduction, horizontal gene transfer and aquisition of selfish DNA, have shaped Rickettsia genomes. These processes may play an important role in free-living bacteria for balancing the size of genome in order to adapt the intracellular life style. In addition, in contrast with the concept of bacteria becoming pathogens by acquisition of virulence factors, rickettsial pathogenecity may be linked to genomic reduction of metabolism and regulation pathways
Wetterbom, Anna. "Genome and Transcriptome Comparisons between Human and Chimpanzee." Doctoral thesis, Uppsala universitet, Genomik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112893.
Full textDickens, Nicholas J. "Comparisons of proteins and genomes by integrating bioinformatics data." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496848.
Full textDörr, Daniel [Verfasser]. "Gene family-free genome comparison / Daniel Dörr." Bielefeld : Universitätsbibliothek Bielefeld, 2016. http://d-nb.info/1096457229/34.
Full textMok, Kwai-lung. "Computational discovery of cis-regulatory modules in human genome by genome comparison." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/b40203621.
Full textMok, Kwai-lung, and 莫貴龍. "Computational discovery of cis-regulatory modules in human genome by genome comparison." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40203621.
Full textBendezu, Angulo Ivan Fedor. "Comparison of genetic variability in European and South American populations of potato cyst nematodes measured by variation in DNA and virulence towards plant resistance genes." Thesis, University of Nottingham, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363597.
Full textMitchell, Candice Melissa. "Morphologic and genomic characterisation of the koala Chlamydia pneumoniae strain." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/33259/1/Candice_Mitchell_Thesis.pdf.
Full textZerbino, Daniel Robert. "Genome assembly and comparison using de Bruijn graphs." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611752.
Full textVorster, Barend Juan. "Using whole genome comparison to detect sequence similarities between plants and microbes." Electronic thesis, 2007. http://upetd.up.ac.za/thesis/available/etd-01192009-142048.
Full textPuterová, Janka. "Porovnání eukaryotních genomů." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2015. http://www.nusl.cz/ntk/nusl-264943.
Full textNovotny, Marian. "Applications of Structural Bioinformatics for the Structural Genomics Era." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7593.
Full textTang, Haibao, Eric Lyons, Brent Pedersen, James Schnable, Andrew Paterson, and Michael Freeling. "Screening synteny blocks in pairwise genome comparisons through integer programming." BioMed Central, 2011. http://hdl.handle.net/10150/610221.
Full text2) providing an efficient software pipeline starting from all-against-all BLAST to the screened synteny blocks with dot plot visualizations. Python codes and full documentations are publicly available http://github.com/tanghaibao/quota-alignment webcite. QUOTA-ALIGN program is also integrated as a major component in SynMap http://genomevolution.com/CoGe/SynMap.pl webcite, offering easier access to thousands of genomes for non-programmers.
Jaša, Petr. "Techniky pro získávání dat v genomice." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2007. http://www.nusl.cz/ntk/nusl-412789.
Full textPeng, Liang. "Neighborhood-Oriented feature selection and classification of Duke’s stages on colorectal Cancer using high density genomic data." Kansas State University, 2011. http://hdl.handle.net/2097/10751.
Full textDepartment of Statistics
Haiyan Wang
The selection of relevant genes for classification of phenotypes for diseases with gene expression data have been extensively studied. Previously, most relevant gene selection was conducted on individual gene with limited sample size. Modern technology makes it possible to obtain microarray data with higher resolution of the chromosomes. Considering gene sets on an entire block of a chromosome rather than individual gene could help to reveal important connection of relevant genes with the disease phenotypes. In this report, we consider feature selection and classification while taking into account of the spatial location of probe sets in classification of Duke’s stages B and C using DNA copy number data or gene expression data from colorectal cancers. A novel method was presented for feature selection in this report. A chromosome was first partitioned into blocks after the probe sets were aligned along their chromosome locations. Then a test of interaction between Duke’s stage and probe sets was conducted on each block of probe sets to select significant blocks. For each significant block, a new multiple comparison procedure was carried out to identify truly relevant probe sets while preserving the neighborhood location information of the probe sets. Support Vector Machine (SVM) and K-Nearest Neighbor (KNN) classification using the selected final probe sets was conducted for all samples. Leave-One-Out Cross Validation (LOOCV) estimate of accuracy is reported as an evaluation of selected features. We applied the method on two large data sets, each containing more than 50,000 features. Excellent classification accuracy was achieved by the proposed procedure along with SVM or KNN for both data sets even though classification of prognosis stages (Duke’s stages B and C) is much more difficult than that for the normal or tumor types.
Ong, Wai, Trang Vu, Klaus Lovendahl, Jenna Llull, Margrethe Serres, Margaret Romine, and Jennifer Reed. "Comparisons of Shewanella strains based on genome annotations, modeling, and experiments." BioMed Central, 2014. http://hdl.handle.net/10150/610105.
Full textTvedte, Eric S. "Genome evolution in parasitic wasps: comparisons of sexual and asexual species." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6516.
Full textBarbee, Bonnie. "Genomic Heterogeneity of Glioblastoma: A Comparison of the Enhancing Tumor Core and the Brain Around the Tumor." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/603560.
Full textOlder, Aguilar Anastazia Magdalena. "Comparison of genomic structure and MHC specificities of killer cell immunoglobulin-like receptors in humans and orangutans /." May be available electronically:, 2009. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textWang, Hao. "THE POTENTIAL INDUCING PATTERN OF THE FLAX GENOME." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1532609009820723.
Full textKastenmüller, Gabriele. "In silico prediction and comparison of metabolic capabilities in sequenced genomes /." München : Hut, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=018929163&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textSturgill, David Matthew. "Comparative Genome Analysis of Three Brucella spp. and a Data Model for Automated Multiple Genome Comparison." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/10163.
Full textMaster of Science
Santos, Almeida Alexandre Miguel. "Evolutionary insights into the host--specific adaptation and pathogenesis of group B Streptococcus Persistence of a dominant bovine lineage of group B Streptococcus reveals genomic signatures of host adaptation Whole-Genome Comparison Uncovers Genomic Mutations between Group B Streptococci Sampled from Infected Newborns and Their Mothers." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066029/document.
Full textStreptococcus agalactiae (group B Streptococcus, GBS) is a commensal of the intestinal and genitourinary tracts in the human population, while also a leading cause of neonatal infections. Likewise, GBS remains a serious concern in many countries as frequently responsible for bovine mastitis. Therefore, the purpose of my PhD project was to use state-of-the-art whole-genome approaches to decipher the host-specific adaptation and pathogenesis of GBS in both humans and bovines. By comparing the genomic profile of strains from infected newborns and their mothers we showed that the transmission of GBS from mother to child is accompanied in particular instances by the acquisition of specific pathoadaptive mutations. Moreover, from the study of the evolutionary forces acting on the human-specific and hypervirulent clonal complex (CC) 17, we reveal that various systems can evolve to improve the ability of GBS to survive in the human host. Functions related to metabolism, cell adhesion, regulation and immune evasion were among the most preferentially affected in GBS strains from human origin. Conversely, colonization of Portuguese dairy farms by one single CC61 clone for over 20 years highlighted that the specific regulation of iron/manganese uptake is a recurrent adaptive strategy in the bovine environment
Nelson, Andrew D. L., Upendra K. Devisetty, Kyle Palos, Asher K. Haug-Baltzell, Eric Lyons, and Mark A. Beilstein. "Evolinc: A Tool for the Identification and Evolutionary Comparison of Long Intergenic Non-coding RNAs." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/624658.
Full textXue, Jianli. "Comparison of ascovirus and baculovirus genomes and their replication and gene expression strategies." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1312568903.
Full textJohnson, Carlena. "AXOLOTL PAEDOMORPHOSIS: A COMPARISON OF JUVENILE, METAMORPHIC, AND PAEDOMORPHIC AMBYSTOMA MEXICANUM BRAIN GENE TRANSCRIPTION." UKnowledge, 2013. http://uknowledge.uky.edu/biology_etds/13.
Full textChoudhuri, Jomuna Veronica. "Bioinformatics approaches to large scale genome comparison, including the identification of conserved noncoding regions." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968573630.
Full textChen, Daidi. "Genetic studies on pleiotropic polyoxin resistant mutants of Bipolaris maydis." Kyoto University, 2018. http://hdl.handle.net/2433/232359.
Full text0048
新制・課程博士
博士(農学)
甲第21158号
農博第2284号
新制||農||1060(附属図書館)
学位論文||H30||N5132(農学部図書室)
京都大学大学院農学研究科地域環境科学専攻
(主査)教授 田中 千尋, 教授 本田 与一, 教授 宮川 恒
学位規則第4条第1項該当
Garg, Kavita. "Genome-wide comparison of evolutionarily conserved alternative and constitutive splice sites /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10260.
Full textRasmussen, Samantha. "Predicting feed efficiency in beef cattle; a comparison of direct measures, expected progeny differences, and single nucleotide polymorphism methodologies." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/theses/2685.
Full textHultman, Cecilia. "Diatom and Cyanobacterial Symbioses : Identifying Environmental MAGs by Comparisons with Known Symbiotic Draft Genomes." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-183999.
Full textBennett, Helen Victoria. "Giardia lamblia : a genome comparison of three reference strains using microarray technology." Thesis, Royal Holloway, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538294.
Full textDe, Maayer Pieter. "Genome comparisons to identify selected pathogenicity factors of a plant-associated Pantoea ananatis strain." Thesis, University of Pretoria, 2010. http://hdl.handle.net/2263/30849.
Full textThesis (PhD)--University of Pretoria, 2010.
Microbiology and Plant Pathology
Unrestricted
Moss, Stephen Paul. "The development of computational methods for large-scale comparisons and analyses of genome evolution." Thesis, University of Hull, 2015. http://hydra.hull.ac.uk/resources/hull:13083.
Full textTurlapaty, Sandhya. "Implementation and Performance Comparison of Some Heuristic Algorithms for Block Sorting." UNF Digital Commons, 2018. https://digitalcommons.unf.edu/etd/816.
Full textMcLeod, Donald Angus. "Comparison of the RNA genomes of persistent and parental strains of human coronavirus 229E." Thesis, University of Ottawa (Canada), 1985. http://hdl.handle.net/10393/4791.
Full textMarsters, Tracy Jane. "Comparison of the complete sequences of the M and F genomes of Mytilus edulis." Thesis, University of Hull, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402495.
Full textTian, Zhixi, Yanjun Yu, Feng Lin, Yeisoo Yu, Phillip SanMiguel, Rod Wing, Susan McCouch, Jianxin Ma, and Scott Jackson. "Exceptional lability of a genomic complex in rice and its close relatives revealed by interspecific and intraspecific comparison and population analysis." BioMed Central, 2011. http://hdl.handle.net/10150/610017.
Full textLantermann, Alexandra. "Comparison of Genome-Wide Nucleosome Positioning Mechanisms in Schizosaccharomyces pombe and Saccharomyces cerevisiae." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-118784.
Full textFrank, Anna Carolin. "Lifestyle and Genome Evolution in Vector-Borne Bacteria : A Comparison of Three Bartonella Species." Doctoral thesis, Uppsala universitet, Molekylär evolution, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5913.
Full textRieber, Nora [Verfasser], and Roland [Akademischer Betreuer] Eils. "Performance comparison of four human whole-genome sequencing technologies / Nora Rieber. Betreuer: Roland Eils." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1061054527/34.
Full textZhao, Zhiyu. "Robust and Efficient Algorithms for Protein 3-D Structure Alignment and Genome Sequence Comparison." ScholarWorks@UNO, 2008. http://scholarworks.uno.edu/td/851.
Full textPereira, Vivian Mayumi Yamassaki. "Reconstrução filogenética de procariotos com base em famílias de genes homólogos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/100/100131/tde-28052017-221803/.
Full textGenome comparison is an important task on which bioinformatics can be used because it allows the identification of pathogen genes which can aid the combat of diseases and to avoid the emerging of new ones. Genome comparison also allows the phylogenetic analysis which provides the understanding of evolutional relations of different organisms. In bacterial genomes, this analysis is commonly based on 16S rRNA gene. Unfortunately, it can present some difficulties to distinguish closely related organisms. This importance of genome comparison and the necessity of a methodology to distinguish organisms that are closely related motivated this study, which aimed the development of computational tools to identify homologous genes in genomes, to use these genes to reconstruct phylogenies and to analyze if it is possible to distinguish closely related organisms on these phylogenies. To achieve this purpose, the developed tools to identify homologous genes receive the alignments results and filter it, such that two genes are homologous if their alignment satisfies the thresholds. After the identification of homologous gene families, the tools generates tables with information about the homologous genes presents in each genome and with these tables it is possible to create distance matrix to be used by hierarchical clustering methods to generate phylogenies or it is possible to perform multiple alignments with the identified genes to accomplish a phylogenetic reconstruction. Besides that, it is possible to represent the genes and homologous gene families in a graph, which can aid the choice of the thresholds to filter the alignments. To demonstrate and analyze the applicability of the developed tools and the approaches chosen in this study, experiments were performed using genomes of the bacterial genus Xanthomonas, which include a group of phytopathogenic bacteria. The results obtained were compared with reference phylogenies and with results of other experiments. These comparisons showed that homologous gene families can be used to differentiate closely related organisms, despite the fact that it presented difficulties to distinguish the groups of genomes that were evolutionarily far from each other. On the other hand, the phylogeny based on 16S rRNA region allows to distinguish the groups of genomes that were distant, but it was not possible to differentiate closely related organisms. As a conclusion, the experiments performed give pieces of evidence that the developed tools and the approaches adopted can be useful to distinguish genomes of closely related organisms of other prokaryotes besides the bacterias considered in this study
Azuero, Andres. "Comparisons of sequential testing approaches for detection of association between disease and haplotype blocks." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/azuero.pdf.
Full text