Journal articles: 'Genitourinary organs'

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Khan, Haroon Sabir, Faaran Kiani, Muhammad Nawaz, Muhammad Sarwar Alvi, Muhammad Rafiq Zafar, and Arshad Mahmood. "GENITOURINARY INJURIES DURING WAR AGAINST TERROR: A SINGLE-CENTER EXPERIENCE." PAFMJ 71, no. 3 (June 29, 2021): 724–28. http://dx.doi.org/10.51253/pafmj.v71i3.3443.

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Objective: To compare our experience of genitourinary injuries during the war against terrorism with the record of those in previous wars of the World. Study Design: Cross sectional study. Place and Duration of Study: Urology department, Combined Military Hospital Peshawar, from Jun 2011 to Aug 2014. Methodology: We treated 89 (5.6%) cases of genitourinary injuries received in our tertiary care hospital in Khyber Pakhtunkhwa. The hospital was located at a distance of 2-3 hours of evacuation time by helicopter from the forward operational area. Results: The frequency of genitourinary injuries among 1589 war casualties was (5.6%). Out of these 49 (55%) were due to sniper shots and 40 (45%) due to improvised explosive device. Kidney was the most common organ injured 30 (33.7%), followed by bladder 20 (22.5%) and urethra 14 (15.7%). Majority of renal and bladder injuries were afflicted in those soldiers who were not wearing the protective jackets. Associated injuries to other organs were identified in 81% cases. Salvage of all genitourinary organs was the aim; however, nephrectomy and orchiectomy had to be performed in 30% and 50% respectively. Conclusion: Salvage of genitourinary war injuries poses a challenge to the trauma surgeon as lifesaving measures take precedence over organ preservation. Renal trauma in war was found to be the leading critical genitourinary injury.

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Zheng, Shuwei, Seow Yen Tan, and Helen ML Oh. "Klebsiella Pneumoniae Visceral Organ Abscesses – Clinical Characteristics." Annals of the Academy of Medicine, Singapore 48, no. 2 (February 15, 2019): 48–54. http://dx.doi.org/10.47102/annals-acadmedsg.v48n2p48.

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Introduction: In recent years, Klebsiella pneumoniae (KP) has emerged as the predominant cause of pyogenic liver abscess in Asia. KP—as the causative microorganism in other visceral organ abscesses—is less described. In this study, we seeked to describe the clinical characteristics of KP visceral organ abscesses in our institution and evaluated the prescription practices of physicians with regard to antibiotic therapy. Materials and Methods: A retrospective analysis of patients with culture positive (blood or abscess aspirate) KP visceral organ abscesses from May 2014 to April 2016 requiring hospitalisation in Changi General Hospital was conducted. Results: A total of 140 adult patients with KP visceral organ abscesses were identified. The commonest site of involvement was the liver (77.9%), followed by genitourinary tract (20.7%). Diabetic patients were more likely to have liver abscesses, genitourinary abscesses, abscesses in 2 or more organs, genitourinary disease with abscess formation outside of the genitourinary tract, and endovascular infection. Patients with extended spectrum beta-lactamase producing KP, were more likely to have an obstructive lesion related to the site of the abscess. Overall mortality rate was 7.1%. Amongst survivors, the mean total duration of parenteral antimicrobial therapy was 2.5 weeks before switching to oral antimicrobial agents. Conclusion: Genitourinary tract is the commonest extra-hepatic site for visceral organ abscess in KP infections. Parenteral to oral switch of antimicrobial agents appears to be a safe and effective treatment option. Key words: Disseminated infection, Genitourinary abscess, Liver Abscess

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Aydın, İrfan, and Erdal Yavuz. "Analysis of genitourinary trauma patients admitted to the emergency department." IMC Journal of Medical Science 15, no. 2 (August 25, 2021): 32–37. http://dx.doi.org/10.3329/imcjms.v15i2.55807.

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Background and objective: Genitourinary injuries are commonly encountered in the emergency department but may be over looked in case of multi-trauma. Determining the clinical features of genitourinary injuries will help physicians in the management of genitourinary trauma. Methods: The study was conducted in a tertiary hospital. Patients of all ages, admitted in the emergency department, with trauma between 2015 and 2020 were included and analyzed. The cause of genitourinary trauma, affected organs, any accompanying injury, treatments, mortality status, and laboratory tests related to mortality were obtained from the hospital records and analyzed. Results: During the study period, 87 patients admitted to the emergency department with genitourinary trauma were included in the study. The majority of these patients (n=79) were male. Of the patients, 9.2% died. All the patients in the mortality group had additional injuries. The most frequently injured organ was determined as the kidney (51.7%), followed by the scrotum (25.3%) and penis (8.1%). Additional injuries were observed in 81.6% of the patients. Intra-abdominal organ injuries (19.5%) were the most common accompanying injuries. White blood cell count (WBC), aspartate aminotransferase (AST), alanine aminotransferase ( ALT), blood glucose and creatinine values measured at the time of admission to the emergency department were found to be higher in the non-survivor group. The majority of the patients (81%) were discharged with conservative treatment and follow-up. Conclusion: It was determined that genitourinary injuries were frequently seen with additional injuries. Genitourinary injury should be evaluated carefully, especially in the presence of intra-abdominal organ injuries. Ibrahim Med. Coll. J. 2021; 15(2): 32-37

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Arkhipov, Evgeniy V., Railya V. Garipova, and Razilya T. Nasibullina. "Tuberculosis as an interdisciplinary problem: a case of occupational damage to the organs of the genitourinary system." Russian Journal of Occupational Health and Industrial Ecology 64, no. 4 (May 20, 2024): 268–73. http://dx.doi.org/10.31089/1026-9428-2024-64-4-268-273.

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In the Russian Federation, genitourinary tuberculosis ranks third in the structure of extrapulmonary tuberculosis. Timely recognition of genitourinary tuberculosis is usually difficult. The authors analyzed a case of occupational infection with tuberculosis of the genitourinary system by a phthisiologist. The clinical observation ended with a clinical cure for tuberculosis of the genitourinary system, however, with the outcome in chronic prostatitis, chronic post-tuberculosis pyelonephritis with the development of chronic kidney disease. It is shown that the timely establishment of a connection between urinary syndrome and epidemiological, including professional anamnesis, contributes to the timely establishment of the professional nature of the disease. With untimely diagnosis and late initiation of treatment of tuberculosis of the genitourinary system, serious complications can develop up to the destruction of the kidney with complete loss of its function, which leads to disability and loss of ability to work. If tuberculosis of the genitourinary system is suspected, experts recommend conducting a study of urine sediment, prostate secretion to determine the deoxyribonucleic acid of mycobacterium tuberculosis by polymerase chain reaction. Any doubt in case of nonspecific inflammation of the genitourinary system should be interpreted in favor of tuberculosis with further in-depth examination and dynamic monitoring.

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Harada, Tadashi, and Teruaki Kigure. "MICROWAVE THERAPY FOR DISEASES OF THE GENITOURINARY ORGANS." Japanese Journal of Urology 83, no. 5 (1992): 589–96. http://dx.doi.org/10.5980/jpnjurol1989.83.589.

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Miyake, Osamu, Mikio Namiki, Takao Sonoda, and Hajime Kitamura. "Secondary Involvement of Genitourinary Organs in Malignant Lymphoma." Urologia Internationalis 42, no. 5 (1987): 360–62. http://dx.doi.org/10.1159/000281993.

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Harada, Tadashi, Teruaki Kigure, Shigeru Miyagata, Kouki Yoshida, Yasuhiro Yuri, Osamu Nishizawa, and Seigi Tsuchida. "Microwave therapy for diseases of the genitourinary organs." Journal of Microwave Surgery 10 (1992): 1–13. http://dx.doi.org/10.3380/jmicrowavesurg1991.10.0_1.

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Huang, C. J. "Rhabdomyosarcoma Involving the Genitourinary Organs, Retroperineum, and Pelvis." Journal of Urology 136, no. 3 (September 1986): 753–54. http://dx.doi.org/10.1016/s0022-5347(17)45059-2.

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Huang, Cheng-Ju. "Rhabdomyosarcoma involving the genitourinary organs, retroperitoneum, and pelvis." Journal of Pediatric Surgery 21, no. 2 (February 1986): 101–7. http://dx.doi.org/10.1016/s0022-3468(86)80058-6.

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Elia, Elissa, David Brownell, Stéphane Chabaud, and Stéphane Bolduc. "Tissue Engineering for Gastrointestinal and Genitourinary Tracts." International Journal of Molecular Sciences 24, no. 1 (December 20, 2022): 9. http://dx.doi.org/10.3390/ijms24010009.

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The gastrointestinal and genitourinary tracts share several similarities. Primarily, these tissues are composed of hollow structures lined by an epithelium through which materials need to flow with the help of peristalsis brought by muscle contraction. In the case of the gastrointestinal tract, solid or liquid food must circulate to be digested and absorbed and the waste products eliminated. In the case of the urinary tract, the urine produced by the kidneys must flow to the bladder, where it is stored until its elimination from the body. Finally, in the case of the vagina, it must allow the evacuation of blood during menstruation, accommodate the male sexual organ during coitus, and is the natural way to birth a child. The present review describes the anatomy, pathologies, and treatments of such organs, emphasizing tissue engineering strategies.

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Shon, Hyun-Chul, Ho-Won Kang, Eic-Ju Lim, and Jae-Young Yang. "Delayed bladder perforation due to screw loosening after pelvic ring injury surgery: a case report." Journal of Trauma and Injury 35, no. 1 (March 31, 2022): 51–55. http://dx.doi.org/10.20408/jti.2021.0054.

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Pelvic ring injuries have high mortality and morbidity rates, and they are difficult to treat because accompanying injuries to the pelvic organs, genitourinary organs, and neurovascular tissues are common. Genitourinary injuries are common comorbid injuries that have been reported to occur in 5% to 6% of all pelvic ring injuries. However, these injuries usually occur simultaneously with the pelvic ring injury, whereas relatively little research has dealt with genitourinary injuries that occur after treatment of a pelvic ring injury. To the best of our knowledge, only three cases of delayed bladder perforation due to screw loosening after symphyseal plate fixation in anterior pelvic ring injury have been reported worldwide, and no such cases have yet been reported in Korea. Since the authors experienced this very rare complication after pelvic ring surgery, we report this case along with a literature review.

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Tikhonova, L. V., G. R. Kasyan, and D. Yu Pushkar. "Postradiation genitourinary fistulae: retrospective study." Experimental and Сlinical Urology 14, no. 3 (September 25, 2021): 170–74. http://dx.doi.org/10.29188/2222-8543-2021-14-3-170-174.

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Introduction. Radiation therapy of the pelvic organs, used to treat malignant neoplasms, is the main cause of urogenital fistula formation (UGF). The widespread use of radiation therapy in the treatment of malignant neoplasms of the pelvic organs has led to an increase in the number of patients with radiation injuries. The study of the prevalence, characteristics and long-term results of surgical treatment of fistulas are of great interest. Materials and methods. There are 76 patients with postradial fistulae received treatment in our Clinic Department of Urology of A.E. Evdokimov Moscow State University of Medicine and Dentistry for the last 6 years from 2012 – through 2018; 49 patients (64.5%) were operated on. The majority of the patients were suffering from vesicovaginal fistula 48.7% (37 people). Transvaginal approach was used in 35 cases (71.4%); abdominal approach was in 7 cases (14.3%); laparoscopic approach was in 3 cases (6.1%); robotic approach took place in 2 cases (4.1%); combined – one case (2%), percutaneous puncture nephrostomy – 1 case (2%). The various flaps technique took place in 40.8% of cases (20/49). Results. In total, radiation indced fistula closed in 35 out of 49 patients successfully. As a result, overall efficiency was 71%. The presented data has included our experience over the past 6 years, which is limited by the standardization of treatment and the lack of some data. Conclusions. Closing the fistula can be performed in several stages: by reducing the size of the fistula and giving patients more time to recover.

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Ibishev, Kh S., A. T. Atadzhanova, E. A. Mamedov, and O. N. Vasilyev. "The significance of coronavirus infection in the development of reproductive and lower urinary tract lesions." Vestnik Urologii 9, no. 2 (July 10, 2021): 125–31. http://dx.doi.org/10.21886/2308-6424-2021-9-2-125-131.

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The impact of COVID-19 on the organs of the genitourinary system is of particular interest to the urologist. There is insufficient information about this influence up to date. The studies are actively developing and require long-term data analysis to determine possible long-term complications, persistent changes in physiological parameters and anatomical and histological structures, as well as to establish the possibility of regression of these changes and complications. The results obtained will undoubtedly improve not only the diagnosis, treatment and prevention of coronavirus infection and its complications, but also make it possible to predict certain disease's outcomes and changes in the function of organs and systems. In turn, this will give an understanding of the measures that need to be taken to completely avoid or minimize these complications and changes.This review focuses on the impact of COVID-19 on genitourinary organs, particularly its place in the development of the lower urinary tract and reproductive organs lesions, as well as the role of androgens in the course of SARS-CoV-2.

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Zargar-Shoshtari, Mohammad Ali, Hossein Saffari, and Mohammad Kazem Moslemi. "Metachronous Occurrence of Triple Malignancies of Kidneys, Prostate, and Breast. A Case Report and Review of The Literature." Case Reports in Urology 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/194620.

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Multiple consecutive cancers involving different organs in a male individual are presented.Case Presentation. Herein, we present a rare case of primary right renal cell carcinoma (RCC), in which two different organ malignancies of prostate and breast were occurred consecutively. After proper treatment of each organ tumor, the patient experienced metachronous occurrence of its final tumor in his remained left kidney as left side RCC.Discussions. Multiple primary cancers are defined as occurrence of two or more malignancies, synchronous or metachronous, in different organs without any relation to each other. For primary and secondary tumors of the male genitourinary system, the most common occurrence was tumors of bladder and prostate followed by tumors of the kidney. Our case was a rare presentation of consecutive occurrence of multiple organ tumors: right side RCC, adenocarcinoma of prostate, and ductal cell carcinoma of the left breast, followed by left side RCC.Conclusions. In any case of primary malignancy of any organ, not only primary tumor recurrence but also tumoral growth of other nonrelated organs should be evaluated, especially in high risk patients or patients with positive familial history.

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Patel, Manish N., and Anthony Atala. "Tissue Engineering of the Penis." Scientific World JOURNAL 11 (2011): 2567–78. http://dx.doi.org/10.1100/2011/323989.

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Congenital disorders, cancer, trauma, or other conditions of the genitourinary tract can lead to significant organ damage or loss of function, necessitating eventual reconstruction or replacement of the damaged structures. However, current reconstructive techniques are limited by issues of tissue availability and compatibility. Physicians and scientists have begun to explore tissue engineering and regenerative medicine strategies for repair and reconstruction of the genitourinary tract. Tissue engineering allows the development of biological substitutes which could potentially restore normal function. Tissue engineering efforts designed to treat or replace most organs are currently being undertaken. Most of these efforts have occurred within the past decade. However, before these engineering techniques can be applied to humans, further studies are needed to ensure the safety and efficacy of these new materials. Recent progress suggests that engineered urologic tissues and cell therapy may soon have clinical applicability.

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Krasnopolskiy, F. "Report on the Gynecological Department of the Kiev-Kirilov Hospital, from June 1 to September 1, 1891." Journal of obstetrics and women's diseases 7, no. 4 (September 10, 2020): 364. http://dx.doi.org/10.17816/jowd74364.

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By June 1, there were 31 patients in the department; for the reporting period, it was again received: with diseases of the external genital organs 7, with diseases of the genitourinary organs 1, with diseases of the uterus 15, with diseases of the tubes and ovaries 4, with diseases of the pelvic peritoneum and cellulose 8, varia 4 and obstetric cases - 4.

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Mitchell, Katharina, Reima El Naili, Lakshmikumar Pillai, Eric Mark Lopez, John Riordan, Wallis Marsh, Adam Luchey, and Ali Hajiran. "Triple Threat: Three Primary Malignancies Simultaneously Involving Three Genitourinary Organs." Case Reports in Urology 2023 (April 17, 2023): 1–6. http://dx.doi.org/10.1155/2023/3242986.

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Statistically, the chance of having concurrent renal cell carcinoma (RCC), urothelial carcinoma of the bladder (UC), and a neuroendocrine tumor (NET) of the renal parenchyma is less than one in a trillion. Herein, we describe an unusual case of a 67-year-old female who presented with bilateral flank pain and severe gross hematuria. Cross-sectional imaging revealed two large heterogeneous, endophytic renal masses with a single enlarged paracaval lymph node. Diagnostic cystoscopy was performed for completion of gross hematuria evaluation and revealed a concurrent papillary bladder tumor. Percutaneous biopsies of bilateral renal masses revealed clear cell RCC involving the left kidney and well-differentiated NET involving the right kidney, and transurethral resection of the bladder tumor revealed high-grade nonmuscle invasive urothelial carcinoma. The patient elected to undergo bilateral nephroureterectomy, radical cystectomy, and retroperitoneal and pelvic lymphadenectomy. Final pathology confirmed the presence of three different malignancies: noninvasive high-grade papillary UC of the bladder (pTaN0), left renal clear cell RCC (pT2bN0), right renal well-differentiated NET, and a single paracaval lymph nodes positive for metastatic NET (pT2aN1).

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Prilepskaya, V. N., and E. G. Nazarenko. "ESTRIOL IN THERAPY OF VARIOUS GYNECOLOGICAL DISEASES." Medical Council, no. 2 (December 30, 2017): 8–13. http://dx.doi.org/10.21518/2079-701x-2017-2-8-13.

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Estriol is an effective and safe drug to treat climacteric syndrome, genitourinary syndrome, in a complex therapy of genital organs prolapsed, atrophic processes at the menopause stage, hypoestrogenia, at cervical factor of infertility.

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Taboada, Phillip, Matthew Lee, Parker Smith, and Jue Wang. "Kidney cancer metastases to breast and other genitourinary (GU) organs: A pooled analysis." Journal of Clinical Oncology 42, no. 4_suppl (February 1, 2024): 401. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.401.

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401 Background: As the number of kidney cancer survivors increases, the appearance of second malignancies and unusual metastatic patterns is increasing. We performed a pooled analysis to assess the clinicopathologic findings, treatment, and outcomes of cases involving breast and GU organs. Methods: Pooled analysis of published case reports and case series of renal cell carcinoma (RCC) metastasis to breast and genitourinary (GU) organs, including four cases from our institution. Parameters were compared between GU organ cohorts using a one-way ANOVA test and subgroup analysis. Results: 127 patients with GU metastasis of RCC were analyzed. The overall mean age was 61.2 years (Range: 14-92). GU organs with reported metastasis included 24 to testis (18.9%), 18 to penis (14.2%), 18 to breast (14.2%), 17 to vagina (13.4%), 17 to bladder (13.4%), 14 to ovary (11%), 7 to prostate (5.5%), and 6 to urethra (4.7%). Median Fuhrman grade was 2.5 overall, with penis metastases (n=4) having a median grade of 4. 95 of 111 (86%) cases reported patients with GU metastasis that had a prior nephrectomy for RCC. Patients with breast metastasis (n=16) had a significantly longer time between nephrectomy and metastatic diagnosis (90.1±63.1 months) than penile (12.7±16.1 months, n=6, p<0.01), bladder (28.7±26.6 months, n=15, p<0.01), or vaginal cohorts (6.7±5.2 months, n=3, p<0.05). Co-metastasis to extra-GU sites were most prevalent in penile metastasis (47.4%, n=9). The primary treatments for metastases were excisional surgery (79%), immunotherapy (18%), radiotherapy (14%), and tyrosine kinase inhibitors (13%). The breast cohort (n=10) reported a 90% survival rate at final follow-up, while the vaginal (n=8) and penile (n=12) cohorts reported survival rates of 50%. The urethra cohort (n=2) had a median survival time of 53 months, while the breast cohort (n=10) had a median survival time of 6 months. Conclusions: While kidney cancer's metastasis to other GU organs is relatively uncommon, it presents unique diagnostic and therapeutic challenges. Recognizing these patterns and understanding the biology behind such spread can offer insights into RCC's behavior and drive more effective treatments. [Table: see text]

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Vissarionov, Sergei Valentinovich, Dmitriy Nikolaevich Kokushin, and Timur Bagaudinovich Bogatyrev. "Malformations of the internal organs and systems in children with asymptomatic spinal dysraphism." Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 3, no. 2 (June 15, 2015): 5–9. http://dx.doi.org/10.17816/ptors325-9.

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The purpose of research is to determine the prevalence of associated malformations in children with latent forms of spinal dysraphism.Materials and methods.The study involved 64 patients aged from 9 months to 17 years old. Clinical and radiological examination including MRI scan of spine and spinal canal were performed to evaluate the orthopaedic and neurological status of the patients.Results.Malformations of the spine were observed in 100 % of children, associated malformations of the organs and systems are found in 33 (52 %) patients. Herewith the malformations of the genitourinary system were revealed - in 52 % of patients, the musculoskeletal system - in 45 % of children, the cardiovascular system - in 39 %, the digestive system - 12 %, otolaryngology - 9 % and bronchopulmonary system - in 3 % of patients.Conclusion.Pediatric patients with latent forms of spinal dysraphism require detailed examination both on the part of the spine and the spinal canal and the internal organs and systems. The most prevalent malformations included those of genitourinary, musculoskeletal (appendicular skeleton) and cardiovascular systems.

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Siregar, Muhammad FG, Masakazu Terauchi, Immanuel DL Tobing, Roni B. Lubis, Selly Azmeila, Hotma P. Pasaribu, Oky Prabudi, Edy Ardiansyah, and Iman H. Effendi. "Role of estradiol and C-reactive protein levels on genitourinary syndrome in menopausal women." Narra J 4, no. 2 (June 24, 2024): e626. http://dx.doi.org/10.52225/narra.v4i2.626.

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Menopause leads to decreased estradiol levels affecting tissue health and causing local inflammation in the genital organs and urinary tract. The rise of blood C-reactive protein (CRP) levels in menopausal women may indicate systemic inflammation associated with estradiol decline. The aim of this study was to determine the relationship between serum estradiol and CRP levels on genitourinary syndrome in menopausal women. A cross-sectional study was conducted among menopausal women who had not experienced menstruation for at least 12 consecutive months at Prof. dr. Chairuddin P. Lubis Hospital, Medan, Indonesia, in 2023. Estradiol and CRP levels were measured using enzyme-linked immunosorbent assay (ELISA) and the presence of genitourinary syndrome was assessed using the Menopause-Specific Quality of Life (MENQOL) questionnaire. The mean levels of estradiol and CRP were compared to menopausal women with and without genitourinary syndrome with the Mann-Whitney test. To assess the correlation between estradiol and CRP levels, and between their levels with the presence of genitourinary symptoms, the Spearman correlation test was used. The genitourinary syndrome was reported in 25% of the total included menopausal women. Our data indicated that the mean estradiol levels were not significantly different between menopausal women with and without genitourinary syndrome (9.13±2.47 pg/mL vs 18.96±31.23 pg/mL, p=0.881). The mean serum CRP level of menopausal women with genitourinary syndrome (9.72±6.30 mg/L) was higher than that of women without the syndrome (2.09±1.26 mg/L) with p<0.001. In addition, serum CRP level, not estradiol, was correlated with the symptom score of genitourinary syndrome. This study highlights that to identify and manage genitourinary syndrome, monitoring of CRP levels is essential in menopausal women.

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OʼCONNELL, KEVIN J., MICHAEL CLARK, RICHARD H. LEWIS, and PAUL J. CHRISTENSON. "Comparison of Low- and High-Velocity Ballistic Trauma to Genitourinary Organs." Journal of Trauma: Injury, Infection, and Critical Care 28, Supplement (January 1988): S139—S144. http://dx.doi.org/10.1097/00005373-198801001-00028.

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Wenzel, Jessica L., Ashley N. Dixon, Anish B. Patel, Jack C. Webb, Praveen N. Satarasinghe, Sadia Ali, Carlos V. R. Brown, J. Stuart Wolf, and E. Charles Osterberg. "Occupational traumatic injuries rarely affect genitourinary organs: a retrospective, comparative study." World Journal of Urology 38, no. 2 (May 7, 2019): 505–10. http://dx.doi.org/10.1007/s00345-019-02796-6.

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Wu, Karen, Joseph A. Posluszny, Jeffrey Branch, Elizabeth Dray, Robert Blackwell, Jessica Hannick, and Fred A. Luchette. "Trauma to the Pelvis: Injuries to the Rectum and Genitourinary Organs." Current Trauma Reports 1, no. 1 (January 10, 2015): 8–15. http://dx.doi.org/10.1007/s40719-014-0006-3.

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Graham, Christopher, Ankita Yelamanchili, Millicent Amankwah, and Philip A. Haddad. "Genitourinary embryonal rhabdomyosarcoma clinicopathologic determinants of clinical outcomes: Analysis of a pooled database." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): e23536-e23536. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e23536.

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e23536 Background: Embryonal rhabdomyosarcoma (ERS) refers to malignant soft tissue tumors with phenotypical, histological features of primitive skeletal muscle. ERS commonly involves the head and neck region and genitourinary system. Genitourinary embryonal rhabdomyosarcoma (GUERS) is considered an entity similar to other ERS based on Intergroup Rhabdomyosarcoma Study Group (IRSG) with non-prostate GUERS considered low risk. This study seeks to define other high-risk subtypes in this population. Methods: To study the demographic and molecular characteristics, therapeutic interventions, survival, and prognostic factors, we compiled a pooled database of 137 cases of GUERS. Kaplan-Meier survival curves, Cox proportional-hazards model and Log-rank tests were used to assess the influence of demographic and clinicopathologic factors on overall survival (OS) and disease-free survival (DFS). Results: 137 patients with confirmed GUERS were identified: median age was 16 and F:M ratio of 1.6. Female reproductive organs (49%), renal and urinary tract (24%), male reproductive organs (23%), and abdomino-pelvis (4%) were involved. Lymph node involvement and metastasis occurred in 11% and 13%, respectively. Staging consisted of stage I (65%), stage II (15%), stage III (8%), and stage IV (12%). Rhabdomyosarcoma clinical groups were mostly IA (41%), IIIA (31%) and IV (13%). Risk groups consisted of low (71%), intermediate (17%), and high (13%). Median OS and DFS were 96 and 42 months, respectively. The primary site of involvement impacted OS, with urinary tract organ involvement having the best median OS, compared to female reproductive organs, male reproductive organs, and abdomino-pelvis involvement (p = 0.01). While primary pelvic disease (p = 0.03), prostate (p = 0.008), and lymph node involvement (p = 0.001) were associated with worse OS, cervix/vaginal involvement tended to have better OS (p = 0.06). Constitutional symptoms (p = 0.0007), obstruction (p = 0.047) and metastases (p = 0.02) were associated with worse OS. Clinical staging system (p = 0.0008), risk groupings (p = 0.06) correlated with OS, but not clinical groupings (p = 0.26). GUERS with vimentin+, CD99- and SMA+ had worse survival (only the latter was statistically significant). Compared to no treatment, RT, CT+/-RT, S+CT+RT were superior with mOS of 2, 6, NR, 96 months, respectively (p < 0.0001). Achieving CR had superior OS (p < 0.0001). OS was not impacted by age, sex, or extent of surgery. Conclusions: Genitourinary embryonal rhabdomyosarcoma is a distinct clinical entity with outcomes worse than other forms of ERS defined by the Clinical Groups of IRSG. Prostate, primary pelvic and obstructive symptoms have worse OS compared to bladder and cervical involvement and we propose their inclusion in the current Clinical Group. This study presents updated clinicopathologic data from a pooled cohort of patients with GUERS.

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Scholz, Holger, and Karin M. Kirschner. "A Role for the Wilms’ Tumor Protein WT1 in Organ Development." Physiology 20, no. 1 (February 2005): 54–59. http://dx.doi.org/10.1152/physiol.00048.2004.

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Wilms’ tumor (nephroblastoma) represents a unique example of an aberrant kidney formation that can result from mutations in a tumor suppressor gene, Wilms’ tumor 1 ( WT1). Targeted gene inactivation in mice testifies that WT1 is a master switch for the development of the genitourinary system and other organs.

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M, Dr Natraj,, Dr Vignesh, S, Dr Nisha Parveen, and Dr Bushra Khan. "Urinary Bladder Tuberculosis – A Case Report." Scholars Journal of Medical Case Reports 11, no. 02 (February 19, 2023): 201–3. http://dx.doi.org/10.36347/sjmcr.2023.v11i02.024.

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Introduction: Genitourinary tuberculosis (GUTB) has varied presentation and affects many organs including urinary bladder. Urinary bladder involvement without the involvement of kidneys is considered rare. Delayed diagnosis causes severe complication including thimble bladder. Here we present case report of 45 year old female patient diagnosed with tuberculous cystitis.

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Nowak, Łukasz, Wojciech Krajewski, Joanna Krajewska, Joanna Chorbińska, Paweł Kiełb, Bartosz Małkiewicz, and Tomasz Szydełko. "Urological Manifestations of the Systemic Vasculitides—A Scoping Review." Uro 1, no. 4 (November 10, 2021): 209–21. http://dx.doi.org/10.3390/uro1040023.

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Background: Vasculitides are specific inflammations of the blood vessel wall that can take place in any organ system of the human body. They may occur as a primary process (primary systemic vasculitides, PSV) or may be secondary to another underlying disease. In general, in association with the specific type of vasculitis, affected vessels vary in size, type, and location. In the following scoping review, we present clinical characteristics and manifestations of PSV with reference to the genitourinary system. Materials and methods: A non-systematic search of the relevant literature was conducted using three electronic databases (PubMed, Embase, and Web of Science) up to 29 October 2021. Results: Urogenital manifestations of PSV are infrequent, with the most commonly reported findings as prostatic or testicular involvements. However, almost all other organs of the genitourinary system can be affected. Conclusions: Because of the clinical heterogeneity and non-specific symptoms, the proper diagnosis of PSV is often delayed and constricted. Fast identification of urological manifestations of vasculitides is essential in implementing appropriate therapy and avoiding unnecessary, harmful, and invasive surgery.

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Kanwal, Saadia, Shazia Batool, Shamoona Naqvi, Naila Israr, Samina Akhtar, and Saadia Zia. "Caudal duplication syndrome: a rare entity." Journal of the Pakistan Medical Association 74, no. 4 (February 11, 2024): 573–75. http://dx.doi.org/10.47391/jpma.8664.

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The rare caudal duplication syndrome is a spectrum of anomalies primarily involving partial or complete duplication of organs comprising the gastrointestinal, genitourinary and distal neural tube systems. These findings are considered to be a result of aberrant embryogenesis. We hereby report a case of an adult female with complete duplication of the genital and urinary systems (urethra and bladder), hindgut and lower end of vertebral column with no functional impairment. She presented in her first pregnancy at 36 weeks gestation, in labour. To the author's knowledge this is the first case of caudal duplication syndrome with pregnancy from Pakistan. Key Words: Caudal duplication, Genitourinary, Gestation, Hindgut.

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Bulyk, R. Ye, O. M. V. Popeliuk, V. V. Melnyk, and D. V. Proniaiev. "Modern view on the germ and embryogenesis of the urinary organs." Reports of Vinnytsia National Medical University 26, no. 2 (June 14, 2022): 328–34. http://dx.doi.org/10.31393/reports-vnmedical-2022-26(2)-27.

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Annotation. The literature is devoted to the analysis of scientific literature for the last 10 years from the electronic databases "PubMed" and "National Library of Ukraine named after V. I. Vernadsky", which are devoted to the study of the formation and development of organs and structures of the urinary system. The consequences of perinatal morphogenesis play the most essential role in the causes and contribution to many congenital malformations (CM), stillbirths, and infant morbidity. According to the Medical and Genetic Service of the Ministry of Health of Ukraine, up to 3,000 cases of CM of various organs and systems are recorded annually among newborns in Ukraine. CM of the genitourinary system ranks 3rd in frequency, among which CM of the female genitalia is up to 6 %. These figures are somewhat subjective, as a certain percentage of pathology of the female reproductive system is detected only when a girl reaches childbearing age, which greatly complicates the choice of methods and effectiveness of treatment. The rapid development of the genitourinary system of the fetus requires morphologists to comprehensively study the patterns of morphogenesis and the development of topographic and anatomical relationships of the reproductive system and urinary tract in the early period of human ontogenesis. The problem of combining information about the structural organization of the urinary tract and genital system into a consolidated morphofunctional unit is one of the cardinal problems of perinatal urology. The final formation of the urogenital organs is as follows. The initial kidneys' replacement with the permanent ones, metanephros, begins to form, from the same nephrogenic cord that gave rise to the primary kidney. The proper permanent renal parenchyma develops from the nephrogenic cord (renal tubuli). From the 3rd month, the permanent kidneys replace the mesonephros as the excretory organs already function. Thus, the embryonic development of the genitals is closely related to the development of the urinary tract and kidneys. Therefore, the CM of these two systems often occurs together. Active introduction of perinatal prophylaxis of urogenital organs requires modern approaches and methods of examination of intrauterine life. Therefore, the complex of embryotopographic studies attains special significance, having combined the consideration of organically critical periods of development with the understanding of the peculiarities of the spatial relationships of organs and structures of the genitourinary system.

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Lippi, Giuseppe, and Fabian Sanchis-Gomar. "Exertional hematuria: definition, epidemiology, diagnostic and clinical considerations." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 12 (November 26, 2019): 1818–28. http://dx.doi.org/10.1515/cclm-2019-0449.

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Abstract Exertional hematuria can be considered a subcategory of exercise-induced hematuria, characterized by painless appearance of erythrocytes in urine after recent physical exercise, not directly attributable to external traumatic injuries to the genitourinary system, and spontaneously resolving with rest. Although its frequency has enormous heterogeneity, depending on the athlete population, duration and intensity of exercise, technique used for identifying or quantifying hematuria and relative diagnostic thresholds, what clearly emerges from the scientific literature is that a certain degree of hematuria is commonplace after non-contact sports, especially running. This exertional hematuria, which appears self-limiting, may be attributable to some frequently concomitant causes, involving organs of the genitourinary system, and mostly encompassing bladder or urethral injuries. Renal injuries caused by internal movements, vascular spasm and ischemia are also potential causes of increased glomerular permeability to erythrocytes, whilst the presence of preexisting genitourinary diseases cannot be ruled out, especially when post-exercise hematuria is recurrent or endures. Therefore, whenever hematuria is observed in a random urine specimen, recent sports performance (especially running) should be investigated and urinalyses scheduled for the following days. When no temporal association of hematuria with exercise can be found, when genitourinary traumas have been excluded or hematuria persists for >72 h, specific diagnostic investigations should be planned to identify possible genitourinary diseases.

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Mandava, Anitha, Veeraiah Koppula, Gaurav Sharma, Meghana Kandati, K. V. V. N. Raju, and T. Subramanyeshwar Rao. "Evaluation of genitourinary fistulas in pelvic malignancies with etiopathologic correlation: role of cross sectional imaging in detection and management." British Journal of Radiology 93, no. 1111 (July 2020): 20200049. http://dx.doi.org/10.1259/bjr.20200049.

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Objective: Genitourinary fistulas in pelvic malignancies are abnormal communications occurring due to either locally advanced tumours invading the surrounding organs or post-therapeutic complications of malignancies. In this article we review and describe the role of cross-sectional imaging findings in the management of genitourinary fistulas in pelvic malignancies. Methods: A retrospective study, for the period January 2012 to December 2018, was undertaken in patients with pelvic malignancies having genitourinary fistulas. The cross-sectional (CT and MRI) imaging findings in various types of fistulas were reviewed and correlated with the primary malignancy and the underlying etiopathology. Results: Genitourinary fistulas were observed in 71 patients (6 males, 65 females). 11 types of fistulas were identified in carcinomas of cervix, rectum, ovary, urinary bladder, sigmoid colon, vault, endometrium and prostate. The commonest were rectovaginal and vesicovaginal fistulas. 13 patients had multiple fistulas. The sensitivity, specificity, positive and negative predictive values of CT and MRI are 98%, 100%, 66%, 98% and 95%, 25%, 88% and 50% respectively. Contrast-enhanced CT with oral and rectal contrast is more sensitive and specific than MRI in the evaluation of genitourinary fistulas. Conclusion: Imaging findings significantly influence the management and outcome of genitourinary fistulas in pelvic malignancies. Contrast-enhanced CT is the imaging modality of choice in the evaluation of pelvic fistulas associated with malignancies and MRI is complimentary to it. Advances in knowledge: To our knowledge, this study is the first of its kind wherein the mean duration of occurrence of fistulas in pelvic malignancies is correlated with the underlying etiopathology.

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Мінухін, Валерій, Інна Торяник, Діана Мінухіна, Сергій Похил, Дмитро Мінухін, Олег Труфанов, and Світлана Калітіна. "REGULARITIES OF MORPHOLOGICAL CHANGES IN THE ORGANS OF THE MALE URINARY AND GENITAL SYSTEM IN CASE OF CRYPTOSPORIDIOSIS (generalized research materials)." Men’s Health, Gender and Psychosomatic Medicine, no. 1-2 (December 30, 2020): 116–23. http://dx.doi.org/10.37321/ujmh.2020.1-2-13.

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The aim of the study was to investigate the structural and functional changes in the male genitourinary system in the development of cryptosporidiosis.Material and methods. The study was based on biopsies and necropsies, based on histological methods.Results. The article is devoted to the study of structural and functional changes in the male genitourinary system in the development of cryptosporidiosis. The authors of the study emphasize the features of the nomenclature profile of cryptosporidiosis, its low certainty, the place among modern protozoal infections. The paper draws attention to the emergence of the disease, the specifics of its clinical course, the characteristics of the most accessible and effective methodological (histological) algorithm. The publication presents data on structural and functional changes of the urethra, testicles, kidneys of children with cryptosporidiosis (proven participation of the inflammatory component, destructive processes, trophic disorders). Researchers have focused on the peculiarities of the structure of the mucous membranes of the genitourinary organs in terms of cryptosporidiosis, destruction of the epithelium, microcirculation disorders. It is assumed that the factors of influence / strengthening of the latter were the activation of lysosomal (hydrolytic) enzymes capable of cleaving lipid - protein complexes of membranes.As a result, the opinion is expressed about the role of cryptosporidiosis in the development of male infertility.Conclusions. In the case of cryptosporidiosis, the most vulnerable structures of the male genitourinary system are cells of mesenchymal origin (epithelium).They are characterized by atrophy, desquamation, destructive-degenerative changes, necrosis. The destruction of the endothelial layer of microvessels leads to defects in the layers of the walls of the latter, thrombosis, the development of stasis, impaired microcirculation and trophism

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Safonov, R. A., and V. V. Lazurenko. "Treatment of genital prolapse in elderly women with genitourinary infection." Bukovinian Medical Herald 27, no. 3 (107) (September 28, 2023): 50–56. http://dx.doi.org/10.24061/2413-0737.27.3.107.2023.9.

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Relevance of the study. Genital prolapse (GP) is a disease that unites a group of disorders of the muscular and ligamentous apparatus of the uterus and vagina, which lead to prolapse and prolapse of the internal genital organs. The incidence of HP in women over 50 reaches 50%, and among elderly and senile women, it increases to 60-70%. Frequent recurrence and the development of septic complications are characterised by urinary tract infections that occur against the background of genital abnormalities, hormone deficiency in the postmenopausal period, diabetes mellitus, asymptomatic bacteriuria, neurogenic bladder dysfunction, urinary incontinence, and surgical interventions on the genital or urinary system.The aim of the study is to optimize the treatment of genital prolapse (GP) in elderly women with urinary and genital infections. Materials and methods. We examined 70 elderly patients, including 20 (28.6%) with GP and infectious lesions of the urinary and genital organs (main group), 30 (42.8%) with GP without infectious lesions of the urinary and genital organs (comparison group), 20 (28.6%) women without gynaecological diseases and extragenital pathology (control group). The severity of the inflammatory process was assessed based on the study of complaints, anamnesis, and laboratory results. The degree of GP was determined using the POP-Q quantitative assessment system. The surgical intervention included transvaginal extirpation of the uterus without appendages, anterior colporrhaphy, colpoperineorrhaphy with levatoroplasty, and sacrospinal colpopexy. Before using the «Polymesh» synthetic mesh endoprosthesis, in order to minimise infectious complications caused by the use of synthetic prostheses, hydrodissection was performed with 0.9% sodium chloride saline (200 ml) with the addition of a third-generation cephalosporin antibiotic (1 g). Results of the study. Patients underwent uterine extirpation without vaginal appendages, unilateral sacrospinal colpopexy, anterior colporrhaphy, colpoperineorrhaphy with levatorrhaphy (in 6 (30%) women of the first group and 13 (43%) - of the second group). Uterine extirpation without vaginal appendages, sacrospinal colpopexy on the left using the «Polymesh» mesh prosthesis, anterior colporrhaphy, colpoperineorrhaphy with levatoroplasty - in 14 (70%) women of the first group and 17 (57%) of the second group. In case of stress urinary incontinence, a mid-urethral sling procedure was additionally performed (6 patients in the first group and 5 in the second). Women with genitourinary infection mainly underwent transvaginal uterine extirpation with unilateral sacrospinal colpopexy and the use of a synthetic mesh prosthesis «Polymesh». The volume of the operation in the form of uterine extirpation using the «Polymesh» prosthesis is due to the reliable effect of the mesh prosthesis in order to prevent the recurrence of the disease compared to sacrospinal colpopexy (1/4% of cases). Conclusions. Surgical treatment of genital prolapse in women with infectious lesions of the urinary and genital organs by using the «Polymesh» mesh prosthesis for colposacropexy after transvaginal uterine extirpation increases the effectiveness of its treatment, reducing the number of recurrences of the disease.

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Muftakhova, G. M., and M. E. Aksenova. "Late effects of antitumor treatment from genitourinary system (delayed influence of antitumor treatment on the organs of the genitourinary system)." Russian Journal of Children Hematology and Oncology 5, no. 4 (January 22, 2019): 114–19. http://dx.doi.org/10.17650/2311-1267-2018-5-4-114-119.

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This article is devoted to the analysis of problems associated with the state of the genitourinary system (GUS) in patients who have undergone a malignant neoplasm in childhood. The main diseases and pathological conditions that can develop in this population are considered. The risks of the development of pathological changes in the kidneys, treatment and prevention are described. Separately, the effects of various types of anticancer therapy (chemoradiotherapy) on GUS were analyzed. Recommendations are given on the definition of risk groups, physical activity and recommended actions.

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Spruill, Laura S., Evelyn T. Bruner, and Michael Timothy Smith. "Genitourinary Updates in the Eighth Edition of the AJCC Cancer Staging Manual." AJSP: Reviews and Reports 23, no. 3 (May 2018): 129–33. http://dx.doi.org/10.1097/pcr.0000000000000241.

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Abstract The new, eighth edition of the AJCC Cancer Staging Manual has been published, and there are many and significant changes in the staging for genitourinary organs. Pathologists will necessarily need to study the manual to acquire fluency in the staging. The staging changes and philosophy will be applicable in 2018. The TNM process involved remains the same, but some specific definition changes are present. Prostate staging is now very different; whereas prior staging included pT2a, pT2b, and pT2c, now all organ-confined disease is pT2 without consideration of half gland involvement. Staging of penis cancer previously considered urethral involvement but now corpus spongiosum involvement is considered pT2, and corpus cavernosum involvement is considered pT3 disease irrespective of the urethral involvement based on literature evidence. Invasion of the epididymis as a component of testis staging is now considered pT2 rather than pT1. These are just some of the new changes that will require understanding on the part of the pathologist. This article describes the changes and some of the background supportive literature and provides appropriate explanatory illustrations.

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Caneparo, Christophe, David Brownell, Stéphane Chabaud, and Stéphane Bolduc. "Genitourinary Tissue Engineering: Reconstruction and Research Models." Bioengineering 8, no. 7 (July 13, 2021): 99. http://dx.doi.org/10.3390/bioengineering8070099.

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Tissue engineering is an emerging field of research that initially aimed to produce 3D tissues to bypass the lack of adequate tissues for the repair or replacement of deficient organs. The basis of tissue engineering protocols is to create scaffolds, which can have a synthetic or natural origin, seeded or not with cells. At the same time, more and more studies have indicated the low clinic translation rate of research realised using standard cell culture conditions, i.e., cells on plastic surfaces or using animal models that are too different from humans. New models are needed to mimic the 3D organisation of tissue and the cells themselves and the interaction between cells and the extracellular matrix. In this regard, urology and gynaecology fields are of particular interest. The urethra and vagina can be sites suffering from many pathologies without currently adequate treatment options. Due to the specific organisation of the human urethral/bladder and vaginal epithelium, current research models remain poorly representative. In this review, the anatomy, the current pathologies, and the treatments will be described before focusing on producing tissues and research models using tissue engineering. An emphasis is made on the self-assembly approach, which allows tissue production without the need for biomaterials.

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Guseva, Gyuldana Raufovna. "Extrapulmonary forms of tuberculosis." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 1 (January 1, 2021): 60–65. http://dx.doi.org/10.33920/med-10-2101-08.

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Extrapulmonary tuberculosis is understood as the localization of the pathological process outside the chest cavity; most frequently, this form has a hematogenous transmission route. There is not a single organ in the human body that could not be affected by tuberculosis, however, some are involved in the pathological process more often than others. In the Russian Federation, tuberculosis of the lymph nodes ranks first in terms of the prevalence of extrapulmonary forms of tuberculosis, while tuberculosis of the genitourinary system and osteoarticular tuberculosis rank second and third, accordingly. In different countries, the proportion of patients with extrapulmonary forms of tuberculosis varies from 4 to 16 %. Due to the difficulty of diagnosis, about a third of cases of extrapulmonary tuberculosis remain undetected. An interesting fact is that pulmonary tuberculosis occurs mainly in men, while extrapulmonary tuberculosis affects women more often (in 59–63 % of cases). This trend is especially clearly traced in tuberculous lesions of the genitourinary system — women account for 75 % of its cases. Osteoarticular tuberculosis has not sexual, but age-specific prevalence: most frequently, it is diagnosed in children aged 0 to 4 years. According to the clinical classification used at the present stage, extrapulmonary forms represent the section «tuberculosis of other organs and systems».

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Atakulov Jamshed Ostonakulovich, Shamsiev Azamat Mukhitdinovich, Yusupov Shukhrat Abdurasulovich, and Shakhriyev Abdikodir Kamalbaevich. "Features of the Genitourinary System in Anorectal Malformations in Children." Texas Journal of Medical Science 20 (May 8, 2023): 43–48. http://dx.doi.org/10.62480/tjms.2023.vol20.pp43-48.

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In anorectal anomalies, combined malformations of the urogenital system are often observed [1,5,7]. This can be explained by the close relationship between the embryonic development of these organs and systems. It is no coincidence that a lot of attention in the literature of the last decade is paid to urological problems of anorectal anomalies [ 12,15,20]. However, the true frequency has not yet been established and the structure of pathological conditions of urogenital system in anorectal anomalies has not been fully studied, the consequences of their delayed diagnosis have not been analyzed, treatment and tactical and operative technical aspects have not been developed and the organizational side of the issue needs improvement

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Kulchavenya, E. V., S. Yu Shevchenko, O. S. Streltsova, V. N. Krupin, and A. A. Baranchukova. "Genital Tuberculosis in Men Living with HIV." Tuberculosis and Lung Diseases 101, no. 6 (December 25, 2023): 28–33. http://dx.doi.org/10.58838/2075-1230-2023-101-6-28-33.

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The objective: to identify structural features of genital tuberculosis in men depending on their HIV status.Subjects and Methods. The medical records of 95 patients with genitourinary tuberculosis were analyzed, and records of patients with isolated tuberculosis of the male genital organs were selected.Results. Among 95 male patients with genitourinary tuberculosis, 72 (75.8%) were HIV-negative, and 23 (24.2%) were HIV-positive. Among 72 HIV-negative male patients, 33 had isolated genital tuberculosis. Among 23 HIV-positive male patients, 9 had isolated genital tuberculosis. HIV infection had a significant impact on the structure of genital tuberculosis in male patients; among cases of isolated genital tuberculosis, tuberculosis of the testicle and its epididymis prevailed (88.9%). In HIV-negative male patients, the prostate gland was affected most often (prostate tuberculosis alone or in combination with tuberculous orchiepididymitis was diagnosed in 90.9% of patients).

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Min, Kyungchan, Seok Joong Yun, Hansoo Park, and Yun-Sok Ha. "Microbiome of Genitourinary Tumors: Especially in Prostate Cancer and Kidney Cancer." Korean Journal of Urological Oncology 19, no. 3 (August 31, 2021): 136–47. http://dx.doi.org/10.22465/kjuo.2021.19.3.136.

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Human body contains diverse microbes. Different microbes are identified at different organs. Urine was thought as sterile, but according to progression in important technologies like 16S rRNA gene sequencing and expanded quantitative urine culture, it is known that diverse microbes exist in genitourinary tract. Microbiome contains the microbes and surrounding microenvironments. In addition to urologic difficulties like interstitial cystitis or chronic prostatitis, malignancies are thought to be related to microbiomes. In this review, we summarized several studies in urologic malignancies, especially prostate cancer and kidney cancer.

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Marte, Antonio, Paolo Indolfi, Carmine Ficociello, Daniela Russo, Matilde Oreste, Gaetano Bottigliero, Giovanna Gualdiero, et al. "Inflammatory Myofibroblastic Bladder Tumor in a Patient with Wolf-Hirschhorn Syndrome." Case Reports in Urology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/675059.

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Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm described in several tissues and organs including genitourinary system, lung, head, and neck. The etiology of IMT is contentious, and whether it is a postinflammatory process or a true neoplasm remains controversial. To our knowledge, we report the first reported case of IMT of urinary bladder in a pediatric patient with Wolf-Hirschhorn (WHS). We also review the literature about patients with associated neoplasia.

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R Ouaddane Alami, N Alaoui Mhammedi, Z Ba, M. Ahsaini, S Mellas, JEl Ammari, MF Tazi, MJ El Fassi, and MH Farih. "Understanding testicular malakoplakia: A rare inflammatory condition and its clinical implications case report." World Journal of Advanced Research and Reviews 18, no. 1 (April 30, 2023): 596–99. http://dx.doi.org/10.30574/wjarr.2023.18.1.0650.

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Genitourinary malakoplakia (GUM) is a rare and chronic form of bacterial soft tissue infection, which primarily affects the genitals and urinary organs. the diagnosis is histological. Symptoms may include itching, pain during sex, bleeding, abdominal pain and burning during urination. Although treatment usually includes antibiotics, corticosteroids or anti-inflammatory drugs, and a variety of other medications and procedures may be needed to treat the symptoms. In some cases, surgery is also indicated.

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Manna, Souvik, Varsha Gupta, and Asha Kumari. "A rare case of genital myiasis in a patient with genital prolapse." Journal of Family Medicine and Primary Care 12, no. 8 (August 2023): 1710–12. http://dx.doi.org/10.4103/jfmpc.jfmpc_1830_22.

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Genital myiasis is an infestation of genital organs by fly larvae, where they feed and develop as parasites. They can cause severe infection, inflammatory reaction and can be linked to psychiatric disturbances. We report a rare case of genital myiasis in an elderly postmenopausal woman aged 82 years from Udaipur, Rajasthan. She presented with complaints of intense pain in the genital region and was diagnosed as a case of genital myiasis of a prolapsed uterus. Pelvic examination revealed ‘Stage-IV’ genitourinary prolapse according to Pelvic Organ Prolapse-Quantification (POP-Q classification), with a big excavatory ulcer indwelled with maggots of Musca domestica. About 100 such maggots were subsequently manually removed with forceps. With proper surgical and nonsurgical interventions, the patient healed completely and the prolapse was reduced completely.

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Bueno Borges, Luisa Pucci, Paulo Igor Teixeira Silva, Francisco Décio De Oliveira Monteiro, Gabriela Melo Alves dos Santos, Maria Eduarda Bastos Andrade Moutinho da Conceição, Vitor Foroni Casas, Ewaldo de Mattos Junior, Kayan Cunha Rossy, Rodrigo Dos Santos Albuquerque, and Pedro Paulo Maia Teixeira. "Assessment of Laparoscopic Adhesiolysis in the Genitourinary Tract of Ewes." Ensaios e Ciência C Biológicas Agrárias e da Saúde 26, no. 3 (November 11, 2022): 287–90. http://dx.doi.org/10.17921/1415-6938.2022v26n3p287-290.

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Peritoneal adhesions are bridges of fibrous tissue that connect two or more structures, and can cause anatomical and functional changes in organs. Adhesions result from the imbalance between fibrinolysis inhibitors and activators, which are mediated by cytokines. After inflammation, there is an increase in vascular permeability and local fibrin exudation. The aim of this study was to assess adhesiolysis in ewes using laparoscopy after adhesion induction in the uterus, ovary, and adjacent organs using monopolar diathermy. Five ewes were used. For adhesion induction, the ewes underwent laparotomy. A skin incision was performed in the mid-inguinal line, exposing the uterus, ovaries and uterine tubes. The adhesion induction was performed at three points on the right side of the uterus and at three points on the right ovary. Laparoscopic adhesiolysis was performed 15 days after the first surgery. After 30 days, a third procedure was made to evaluate resolution after adhesiolysis. One animal died after the surgery, the necropsy revealed a fistula due to adhesions that resulted in acute peritonitis. Concerning classification, adhesiolysis was impossible in one ewe (25%), partially possible in the reproductive tract, adjacent organs, omentum, and abdominal wall in two ewes (50%), partially possible in reproductive tract in one ewe (25%), and totally possible in none of the ewes. This study shows that monopolar diathermy can induce adhesions. The endo-surgery was only partially effective regarding morbidity, it produced good results as it reduces the occurrence of injuries and promotes clinical improvement by allowing abdominal adhesiolysis. Keywords: Adhesions Treatment. Fibrous Tissue. Laparoscopy. Monopolar Diathermy. Ovary. Resumo As aderências peritoneais são pontes de tecido fibroso que conectam duas ou mais estruturas, podendo causar alterações anatômicas e funcionais em órgãos. As aderências resultam do desequilíbrio entre os inibidores e ativadores da fibrinólise, que são mediados por citocinas. Após a inflamação, ocorre aumento da permeabilidade vascular e exsudação local de fibrina. O objetivo deste estudo foi avaliar a adesiólise em ovelhas por meio de laparoscopia após a indução de aderências no útero, ovário e órgãos adjacentes por meio de diatermia monopolar. Foram utilizadas cinco ovelhas. Para indução de aderências, as ovelhas foram submetidas a laparotomia. Uma incisão na pele foi realizada na linha inguinal média, expondo o útero, ovários e tubas uterinas. A indução da adesão foi realizada em três pontos do lado direito do útero e em três pontos do ovário direito. A adesiólise videolaparoscópica foi realizada 15 dias após a primeira cirurgia. Após 30 dias, um terceiro procedimento foi realizado para avaliar a resolução após adesiólise. Um animal morreu após a cirurgia, a necropsia revelou uma fístula devido a aderências que resultaram em peritonite aguda. Com relação à classificação, adesiólise foi impossível em uma ovelha (25%), parcialmente possível no trato reprodutivo, órgãos adjacentes, omento e parede abdominal em duas ovelhas (50%), parcialmente possível no trato reprodutivo em uma ovelha (25%), e totalmente possível em nenhuma das ovelhas. Nosso estudo mostra que a diatermia monopolar pode induzir aderências. A endocirurgia foi apenas parcialmente eficaz quanto à morbidade, apresentou bons resultados, pois reduz a ocorrência de lesões e promove melhora clínica ao permitir adesiólise abdominal. Palavras-chave: Tratamento de Aderências. Tecido Fibroso. Laparoscopia. Diatermia Monopolar. Ovário.

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Kaya, Ecem, Suresh C. Sikka, Didem Yilmaz Oral, Isil Ozakca, and Serap Gur. "β3-Adrenoceptor Control of Lower Genitourinary Tract Organs and Function in Male: An Overview." Current Drug Targets 19, no. 6 (April 16, 2018): 602–12. http://dx.doi.org/10.2174/1389450118666170120165554.

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Suvorova, Suvorova V. A., Dobrokhotova Yu E. Dobrokhotova, Ilyina I. Yu Ilyina, Venediktova M. G. Venediktova, Sarantsev A. N. Sarantsev, and Morozova K. V. Morozova. "Genitourinary disorders after combined and complex treatment for cancer of the female reproductive organs." Akusherstvo i ginekologiia 11_2016 (November 27, 2016): 28–33. http://dx.doi.org/10.18565/aig.2016.11.28-33.

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Pinto, F., A. Calarco, A. Brescia, E. Sacco, A. D'addessi, M. Racioppi, and P. F. Bassi. "Regenerative Medicine: Applications and Development in Urology." Urologia Journal 74, no. 4 (October 2007): 197–205. http://dx.doi.org/10.1177/039156030707400402.

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Purpose Congenital abnormalities and acquired disorders can lead to organ damage and loss. Nowadays, transplantation represents the only effective treatment option. However, there is a marked decrease in the number of organ donors, which is even yearly worsening due to the population aging. The regenerative medicine represents a realistic option that allows to restore and maintain the normal functions of tissues and organs. This article reviews the principles of regenerative medicine and the recent advances with regard to its application to the genitourinary tract. Recent findings The field of regenerative medicine involves different areas of technology, such as tissue engineering, stem cells and cloning. Tissue engineering involves the field of cell transplantation, materials science and engineering in order to create functional replacement tissues. Stem cells and cloning permit the extraction of pluripotent, embryonic stem cells offering a potentially limitless source of cells for tissue engineering applications. Most current strategies for tissue engineering depend upon a sample of autologous cells from the patient's diseased organ. Biopsies from patients with extensive end-stage organ failure, however, may not yield enough normal cells. In these situations, stem cells are envisaged as being an alternative source. Stem cells can be derived from discarded human embryos (human embryonic stem cells), from fetal tissue or from adult sources (bone marrow, fat, skin). Therapeutic cloning offers a potentially limitless source of cells for tissue engineering applications. Regenerative medicine and tissue engineering scientists have increasingly applied the principles of cell transplantation, materials science and bioengineering to construct biological substitutes that will restore and maintain normal function in urological diseased and injured tissues such as kidney, ureter, bladder, urethra and penis. Conclusions Regenerative medicine offers several applications in acquired and congenital genitourinary diseases. Tissue engineering, stem cells and, mostly, cloning have been applied in experimental studies with excellent results. Few preliminary human applications have been developed with promising results.

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Narutdinov, D. A., R. S. Rakhmanov, E. S. Bogomolova, S. A. Razgulin, and N. N. Potekhina. "Estimation of morbidity of military personnel under contract in extreme living conditions." Sanitarnyj vrač (Sanitary Doctor), no. 11 (November 20, 2023): 735–44. http://dx.doi.org/10.33920/med-08-2311-06.

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We analyzed the incidence of military personnel in the Arctic, subarctic (Arctic zone) and continental climatic zones for 2015–2020. In terms of the prevalence of diseases, the highest registration was determined in the Subarctic, respectively 3493.2 ± 12.7‰, 3692.6 ± 19.2‰ and 2610.1 ± 72.6‰. However, in the conditions of the Arctic, it is difficult to provide general medical or specialized medical care due to the duration of non-flying weather. The incidence of the class «Diseases of the genitourinary system» in the Arctic exceeded that in other climatic zones, 1.3–1.6 times. In the Subarctic, the most highly recorded pathology of the digestive system. For diseases of the respiratory and digestive organs, genitourinary, musculoskeletal, endocrine systems and blood circulation, the excess in the Arctic zone, compared with the continental climate, reached 1.3–2.0 times. Primary morbidity in different climatic zones did not differ. The first four ranking places were left for diseases of the respiratory, genitourinary, musculoskeletal and endocrine systems. In the conditions of the Arctic zone, traumatism was relevant, and in the conditions of the Subarctic and continental climates, diseases of the ear and its mastoid process. The prevalence of diseases in the Arctic zone proves the influence of weather and climate conditions on the health of servicemen. Differences in the prevalence of diseases in the Arctic and Subarctic regions were determined by the class «Diseases of the genitourinary system»: 2nd and 6th ranking places (excess by 1.3 times, p = 0.01). In the continental climate, indicators for diseases of the genitourinary, musculoskeletal and endocrine systems, the circulatory system and the digestive system did not differ. In the Arctic zone, data on diseases of the endocrine system did not differ and were less significant (by 1.3–1.4 times) than in the continental belt, but the injury rate was 1.5–2.1 times higher. The revealed features in the long-term dynamics of the incidence of military personnel allow us to adjust the directions of preventive activities.

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Guana, A. L., and P. R. Cohen. "Transient acantholytic dermatosis in oncology patients." Journal of Clinical Oncology 12, no. 8 (August 1994): 1703–9. http://dx.doi.org/10.1200/jco.1994.12.8.1703.

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PURPOSE To evaluate the characteristics of patients with cancer who have a previous history, concurrent episode, or subsequent appearance of transient acantholytic dermatosis (TAD). METHODS We report four oncology patients who developed TAD and review the 22 reports that have previously been published of individuals in whom TAD appeared either before, concomitant with, or after the diagnosis of their malignancy. RESULTS TAD was associated more frequently in patients with hematologic malignancies, especially acute and chronic myelogenous leukemia. It also appeared in patients with solid tumors, primarily those of the genitourinary organs. In almost all the cases, the onset of TAD was either concurrent or followed the discovery of malignancy. The TAD resolved completely, with or without treatment, in at least 20 patients in a median of 3 weeks. CONCLUSION TAD is a benign and temporary condition that may occur in patients with an internal malignancy. When the diagnosis of TAD is being considered, a lesional skin biopsy readily establishes histologic confirmation in a febrile patient with cancer who develops a new rash. TAD has been observed most frequently in oncology patients who have either myelogenous leukemia or carcinoma of the genitourinary organs. The appearance of TAD coincided with either the detection or the recurrence of malignancy in three individuals (12%). In the other 23 oncology patients, TAD was most likely secondary to either antineoplastic agents, excessive perspiration, fever, occlusive immobility, and/or ionizing or UV radiation.

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Journal articles on the topic 'Genitourinary organs'

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