Relevant bibliographies by topics / Genetics – Research

Academic literature on the topic 'Genetics – Research'

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Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Genetics – Research"

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Burrow, H. M., and B. M. Bindon. "Genetics research in the Cooperative Research Centre for Cattle and Beef Quality." Australian Journal of Experimental Agriculture 45, no. 8 (2005): 941. http://dx.doi.org/10.1071/ea05069.

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In its first 7-year term, the Cooperative Research Centre (CRC) for the Cattle and Beef Industry (Meat Quality) identified the genetic and non-genetic factors that impacted on beef eating quality. Following this, the CRC for Cattle and Beef Quality was established in 1999 to identify the consequences of improving beef eating quality and feed efficiency by genetic and non-genetic means on traits other than carcass and beef quality. The new CRC also had the responsibility to incorporate results from the first Beef CRC in national schemes such as BREEDPLAN (Australia’s beef genetic evaluation scheme) and Meat Standards Australia (Australia’s unique meat grading scheme that guarantees the eating quality of beef). This paper describes the integrated research programs and their results involving molecular and quantitative genetics, meat science, growth and nutrition and industry economics in the Beef CRC’s second phase (1999–2006) and the rationale for the individual genetics programs established. It summarises the planned scientific and beef industry outcomes from each of these programs and also describes the development and/or refinement by CRC scientists of novel technologies targeting increased genetic gains through enhanced measurement and recording in beef industry herds, thereby ensuring industry use of CRC results.
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FRAZIER, LORRAINE, and SHARON K. OSTWALD. "Genetics and Gerontological Nursing: A Need to Stimulate Research." Annual Review of Nursing Research 20, no. 1 (January 2002): 323–37. http://dx.doi.org/10.1891/0739-6686.20.1.323.

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The purpose of this chapter is to discuss how genetics will affect gerontological nursing. The chapter will answer two questions: (1) Which aspects of genetics will be most relevant to future gerontological nursing practice? and (2) What will be the impact of genetics on the future of gerontological nursing education and research? MEDLINE was searched for relevant articles from 1995 to 2001 using the key words aging, genetics, geriatrics, nursing education, research, and gerontology. CRISP was searched using the thesaurus terms education/planning, genetics, health education, model design/development, psychological model, pubic health curriculum, behavioral/social science research, and research nursing/genetics. A total of 101 nursing and nonnursing articles were reviewed. Research reports were selected if they focused on issues related to gerontological nursing. Articles were reviewed that had application to genetic nursing, complex diseases, and genetics.The evolution of the science of genetics will revolutionize gerontological nursing and affect future nursing education and research as the concepts of genetic science and the technology they generate are translated into everyday clinical practice. Genetic discoveries in common complex diseases will affect care provided by gerontological nurses in the 21st century. Gerontological nurses must move quickly to recognize this genetic paradigm shift and to incorporate genetics issues into their nursing practice.
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Aiello, Lisa, Jeffrey Petersen, Julie Ann Lynch, Lori Hoffman-Hogg, Nevena Damjanov, Kyle William Robinson, Yu-Ning Wong, Darshana Jhala, and Kara Noelle Maxwell. "Outcomes of an advanced practice nurse (APN)-led cancer genetics service." Journal of Clinical Oncology 40, no. 6_suppl (February 20, 2022): 71. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.071.

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71 Background: In oncology practice, there are increasing numbers of patients for whom genetic testing is recommended by the National Cancer Care Network (NCCN), including all metastatic and high-risk localized prostate cancer patients. However, there is a critical shortage of genetics services providers. Acuity for these consults can be high, particularly in the context of a treatment related decision. We hypothesized that nurses, particularly advanced practice nurses (APNs), can provide a workforce within VA that can address genetic testing and genetic care needs of prostate cancer patients. Methods: We initiated a cancer genetics service staffed with an advanced practice nurse (APN) geneticist and evaluated the success of the program at a large urban, academic-affiliated Veteran’s Affairs Medical Center (VAMC). Results: In the one year prior to the initiation of the APN geneticist-run program (10/1/2019-9/30/2020), 61 unaffected patients with a family history of cancer and 85 patients with cancer (36 with prostate cancer) were referred to a VA centralized telegenetics service. An average of seven cancer patients (average three with prostate cancer) were referred to VA telegenetics per month. Genetic testing was completed in eleven (18%) of unaffected patients and 21 (25%) of cancer patients. Five (13%) of tested patients were found to have a pathogenic or likely pathogenic mutation or variant of uncertain significance (VUS). In the eight months after initiation of the APN geneticist-run consult service (10/1/2020 - 5/30/2021), 39 unaffected patients with a family history of cancer and 90 patients with cancer (38 with prostate cancer) were referred. An average of 11 cancer patients (average five with prostate cancer) per month were referred. This represents a 57% increase in all cancer patient and a 67% increase in prostate cancer patient referrals. For those patients referred to the APN geneticist-run consult service, genetic testing was completed in three (7%) of unaffected patients and 30 (33%) of cancer patients (including 15 prostate cancer patients). The genetic testing rate therefore improved from 1.7 oncology patients per month to 3.9 oncology patients per month, an 130% increase in genetic testing. For prostate cancer patients, the genetic testing rate improved from 0.8 to 1.9 patients tested per month, representing a 137% increase. Comparison of genetic testing outcomes at one year will be included in the final presentation. Conclusions: Inclusion of an APN geneticist-run consult service embedded in oncology clinics will likely improve access to genetics services and genetic testing rates in cancer patients.
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Mort, Mona A. "Ecological genetics of freshwater zooplankton: Current research and future perspectives." Archiv für Hydrobiologie 123, no. 2 (December 6, 1991): 129–41. http://dx.doi.org/10.1127/archiv-hydrobiol/123/1991/129.

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Dermody, Terence S., and Julie K. Pfeiffer. "Genetics in Virology Research." Annual Review of Virology 2, no. 1 (November 9, 2015): vii—x. http://dx.doi.org/10.1146/annurev-vi-2-102915-100011.

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Plomin, Robert, and Claire M. A. Haworth. "Genetics and Intervention Research." Perspectives on Psychological Science 5, no. 5 (September 2010): 557–63. http://dx.doi.org/10.1177/1745691610383513.

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Morpurgo, Giorgio. "Research inAspergillus nidulans genetics." Genetica 94, no. 2-3 (June 1994): 283–89. http://dx.doi.org/10.1007/bf01443442.

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Fuller, B. P. "ETHICS:Privacy in Genetics Research." Science 285, no. 5432 (August 27, 1999): 1359–61. http://dx.doi.org/10.1126/science.285.5432.1359.

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Maheswarappa, B. S., and A. Vinutha. "Collaborative research in genetics." International Library Review 21, no. 2 (April 1989): 173–76. http://dx.doi.org/10.1016/0020-7837(89)90005-8.

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Shumny, V. K. "Development of genetic research in the USSR." Genome 31, no. 2 (January 15, 1989): 900–904. http://dx.doi.org/10.1139/g89-160.

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Two periods of the development of genetic research in the USSR with reference to its current trends of plant and animal genetics, cytogenetics, and molecular genetics are reviewed. A short list of priority areas is established: the maintenance and use of unique gene pools of plants and animals; the domestication of animals and cultivation of new plants; the development of programmes for mathematical treatment of genetic data banks. It is suggested to consider them within the framework of international projects. The idea is to promote the collaborative efforts of scientists on an international scale.Key words: genetics in the USSR, current trends, international cooperation.
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Dissertations / Theses on the topic "Genetics – Research"

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Povinelli, Christine Marie. "Genetic analysis of the dihydrofolate reductase and thymidylate synthase genes of bacteriophage T4." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/25347.

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Hawkins, Naomi. "Human gene patents and translational research in genetics." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527328.

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Chuang, William 1970. "Design of a genetics database for medical research." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/86291.

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Thesis (S.B. and M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.
Includes bibliographical references (leaves 54-57, first group).
by William Chuang.
S.B.and M.Eng.
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Loh, Yong-Hwee Eddie. "Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41148.

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Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. In this single natural system, numerous morphological (eg. jaw and tooth shape, color patterns, visual sensitivity), behavioral (eg. bower-building) and physiological (eg. development, neural patterning) phenotypes have emerged, much akin to a mutagenic screen. This dissertation encompasses three studies that seek to decipher the underpinnings of such rapid evolutionary diversification, investigated via the genetic variation in East African cichlids. We generated a valuable cichlid genomic resource of five low-coverage Lake Malawi cichlid genomes, from which the general properties of the genome were characterized. Nucleotide diversity of Malawi cichlids was low at 0.26%, and a sample genotyping study found that biallelic polymorphisms segregate widely throughout the Malawi species flock, making each species a mosaic of ancestrally polymorphic genomes. A second genotyping study expanded our evolutionary analysis to cover the entire East African cichlid radiation, where we found that more than 40% of single nucleotide polymorphisms (SNPs) were ancestral polymorphisms shared across multiple lakes. Bayesian analysis of genetic structure in the data supported the hypothesis that riverine species had contributed significantly to the genomes of Malawi cichlids and that Lake Malawi cichlids are not monophyletic. Both genotyping studies also identified interesting loci involved in important sensory as well as developmental pathways that were well differentiated between species and lineages. We also investigated cichlid genetic variation in relation to the evolution of microRNA regulation, and found that divergent selection on miRNA target sites may have led to differential gene expression, which contributed to the diversification of cichlid species. Overall, the patterns of cichlid genetic variation seem to be dominated by the phenomena of extensive sharing of ancestral polymorphisms. We thus believe that standing genetic variation in the form of ancestrally inherited polymorphisms, as opposed to variations arising from new mutations, provides much of the genetic diversity on which selection acts, allowing for the rapid and repeated adaptive radiation of East African cichlids.
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Bell, Jordana Tzenova. "Epistasis in complex human traits." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:547db446-c84c-4a6c-8b5c-ce960f7765c5.

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Withgott, Jay. "Genes for Queens: Understanding More About Bee Genetics." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2000. http://hdl.handle.net/10150/622276.

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Aldous, Colleen Michelle. "University level genetics students' competencies in selected science process skills." Diss., Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-02092006-120752.

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Webb, Sim F. "Cell culture of human lens epithelia in cataract research." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320778.

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A, Volta. "Genetics of Familial Hypercholesterolemia: new diagnostic and research approaches." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1071514.

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Introduction: Familial Hypercholesterolemia (FH, OMIM #143890) is an autosomal dominant disorder of lipoprotein metabolism characterized by high plasma levels of LDL cholesterol (LDL-C) with an estimated prevalence of 1 in 250 individuals in Western Europe. Lifelong exposure to elevated plasma levels of LDL-C leads to atherosclerosis at an early age, and as such FH patients are at a 2.2 to 25.8 fold higher risk for cardiovascular disease (CVD). FH is caused by genetic mutations that affect the structure and/or function of the LDL receptor (LDLR), a cell-surface receptor that removes LDL from the circulation. Variants in LDLR, APOB, and PCSK9 have been shown to result in clinical FH. To date, FH is an underdiagnosed and undertreated disease as exemplified by the fact that less than 1% of the worldwide familial hypercholesterolemia population is detected, diagnosed or treated according to current guidelines. Aims: The primary aim was to promote a combined clinical and genetic approach for the diagnosis of FH in order to achieve a definitive and early diagnosis in patients, allow a prompt treatment and, thus, prevent the occurrence of CVD. Since a mutation in one of the three FH main genes is found in only 60-80% of patients with a definitive clinical diagnosis, the second aim of this PhD was to exploit genetic data, derived from the use of new DNA high-throughput sequencing (HTS) technologies, to find new molecular pathways (major or modifier genes) causing the disease. In particular, the possible association of genetic variants in ABCG5/ABCG8 and STAP1 with FH-like phenotype was investigated. Methods and Results: Through a 55 genes targeted HTS, we set out a fast and cost-effective genetic screening for patients with a clinic suspect or a definite diagnosis of FH. In the first 2 years we analysed 32 patients and we were able to make a molecular definitive FH diagnosis in 14 of them. Our HTS design allowed also to obtain information about pharmacogenetics and genetic predisposition to other forms of dyslipidemia. The application of the 12 SNPs gene score in our FH cohort confirmed, as previously shown in literature, that the high LDL-C levels in FH patients could be due to an accumulation of several common genetic variants of small effect supporting the presence of the polygenic form of FH. Through a lipid profiles evaluation in a big cohort of clinical FH patients and a co-segregation analysis in 4 FH families, it was then demonstrated that heterozygous variants in ABCG5/ABCG8 genes do not cause monogenic FH, although it cannot be ruled out that they can have a role in the regulation of serum cholesterol levels. Lastly, the screening of plasma lipids and B cell profile of STAP1 variant carriers coupled with in vitro co-culture experiments allowed to demonstrate that variants in STAP1 are not associated with elevated LDL cholesterol in FH patients. Thus, in contrast to the previous literature findings, STAP1 cannot be considered the fourth FH gene. Conclusions: This PhD thesis provides a large view on familial hypercholesterolemia, a disease with an ever higher estimated worldwide prevalence, and remarks the importance and feasibility of an early diagnosis supported by a cost-effective genetics diagnosis approach to manage and prevent CVD. Indeed, genetics can definitely help to improve diagnosis efficiency and to quickly identify new patients within the families. Moreover, research of new genetic FH causes and the identification of novel molecular pathways causing the disease may be the groundwork to the development of novel and ever more safety and effective lipid lowering drugs.
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Ratchford, Cynthia W. "A study of support for genetic research genetic services and education in genetics among African American social workers in metropolitan Atlanta." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2001. http://digitalcommons.auctr.edu/dissertations/2828.

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This study examined African American social workers' opinions about genetic research, genetic services, and education in genetics and selected factors associated with their opinions. Those factors were professional/work experience with clients with genetic issues; mass media exposure to genetic information: t.v., movies, newspapers, magazines; graduate social work course/unit in a course in genetics; personal/family experience with genetic issues; and gender. There are no available studies on the readiness of African American social workers to practice in human genetic service delivery. This study was based on the premise that African American social workers' opinions about human genetics as a discipline would be an indicator of their readiness to practice in genetics. Frequency analysis, crosstabulation and multiple regression were the statistics employed to analyze the data. The findings indicated that African American social workers were supportive of genetic services and education in genetics, but had mixed opinions about genetic research. Based upon these findings, African American social workers appear to be a group that is ready to fill a unique need for social work practitioners in genetics. Mass media exposure to genetics and gender were the variables that were most associated with the African American social workers' opinions. Several of the independent variables had a slight relationship to the criterion variables. These relationships indicated an interplay of complex factors that were associated with African American social workers' support for genetic research, genetic services and education in genetics. Those factors indicated that experience with or exposure to genetics may have influenced African American social workers to support genetics in general. It was recommended that graduate schools of social work and social work professional associations develop educational programming that focuses on exposing African American graduate social work students and social work practitioners to genetics. This study employed convenience sampling to maximize the participation of African American social workers and conclusions apply only to the study sample.
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Books on the topic "Genetics – Research"

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Loback, Michael T., and Jennifer N. Trevino. Encyclopedia of genetics research. New York: Nova Science Publishers, 2011.

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Loback, Michael T., and Jennifer N. Trevino. Encyclopedia of genetics research. New York: Nova Science Publishers, 2011.

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Smith, Moyra. Translational research in genetics and genomics. Oxford: Oxford University Press, 2008.

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Smith, Moyra. Translational research in genetics and genomics. Oxford: Oxford University Press, 2008.

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T, Koven Viktor, ed. Population genetics research progress. New York: Nova Science, 2008.

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Fabricio, González Andrade, ed. Forensic genetics research progress. Hauppauge, N.Y: Nova Science, 2009.

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H, Columbus Frank, and Craven Jasper C, eds. DNA research. New York: Nova Science Publishers, 2005.

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G, Hernandes A., ed. Antisense elements (genetics) research focus. Hauppauge, N.Y: Nova Science Publishers, 2007.

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K, Wong David, ed. Tumorigenesis research advances. New York: Nova Science Publishers, 2007.

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A, McNamara Peter, ed. Trends in RNA research. New York: Nova Science Publishers, 2006.

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Book chapters on the topic "Genetics – Research"

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Williams, Thomas N. "Host genetics." In Advances in Malaria Research, 465–94. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118493816.ch17.

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Joseph, Jay. "Schizophrenia Adoption Research." In Schizophrenia and Genetics, 121–74. New York: Routledge, 2022. http://dx.doi.org/10.4324/9781003293279-6.

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Joseph, Jay. "Schizophrenia Twin Research." In Schizophrenia and Genetics, 95–120. New York: Routledge, 2022. http://dx.doi.org/10.4324/9781003293279-5.

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Lewis, Browne C. "Genetic Research and the Law." In Stroke Genetics, 411–23. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56210-0_18.

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Lewis, Browne C. "Genetic Research and the Law." In Stroke Genetics, 585–99. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-41777-1_20.

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Rege, J. E. O., Joel Ochieng, and Olivier Hanotte. "Livestock genetics and breeding." In The impact of the International Livestock Research Institute, 59–102. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789241853.0059.

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Abstract This chapter describes the contributions of the International Livestock Research Institute's (ILRI) to animal breeding. The specific topics include the genetic characterization and history of livestock, breeding technologies, genetic improvement of indigenous livestock, tools and methods for conducting breed surveys, classification of African livestock populations, molecular genetic characterization, the genetic history of cattle in Africa and linking livestock to human history, genetic history and geography of African sheep, genetic history and geography of African chickens, genetic history and geography of the African dromedary, establishment of a joint laboratory with CAAS in Beijing and expansion into Asia, ILRI's genetic characterization as a catalyst for international interest, genetics of trypanotolerance and genetics of resistance to gastrointestinal parasites.
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Goodwin, Donald W. "Genetics of Alcoholism." In Research in Psychiatry, 359–72. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4899-0688-5_14.

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Frost, Caren J., Lisa H. Gren, L. Scott Benson, and Margaret Carlson. "Genetics and Biospecimens." In Global Research Ethics, 105–21. London: Routledge, 2023. http://dx.doi.org/10.4324/9781003033233-8.

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Vogel, Friedrich, and Arno G. Motulsky. "Behavioral Genetics: Research Strategies and Examples." In Human Genetics, 623–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-03356-2_16.

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Joseph, Jay. "Schizophrenia Molecular Genetic Research." In Schizophrenia and Genetics, 24–56. New York: Routledge, 2022. http://dx.doi.org/10.4324/9781003293279-2.

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Conference papers on the topic "Genetics – Research"

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MENDLEWICZ, J. "MOLECULAR GENETICS IN PSYCHIATRY RESEARCH." In IX World Congress of Psychiatry. WORLD SCIENTIFIC, 1994. http://dx.doi.org/10.1142/9789814440912_0004.

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Fan, QiaoChu, Zi jie Lu, and Yu chen Liu. "Statistical research methods for genetics." In 2nd International Conference on Applied Mathematics, Modelling, and Intelligent Computing (CAMMIC 2022), edited by Chi-Hua Chen, Xuexia Ye, and Hari Mohan Srivastava. SPIE, 2022. http://dx.doi.org/10.1117/12.2639273.

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"Biotechnological approaches in breeding and genetic research of soybean." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-049.

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"Application of SeedCounter app in genetic research." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology (PlantGen2023). FRC Kazan Scientific Center RAS, Kazan, Russia;Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 2023. http://dx.doi.org/10.18699/plantgen2023-29.

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Ouyang, Jing. "Research Advances in Animal Genetics Breeding Method." In 4th International Conference on Management Science, Education Technology, Arts, Social Science and Economics 2016. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/msetasse-16.2016.293.

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Green, Nancy. "Identifying Argumentation Schemes in Genetics Research Articles." In Proceedings of the 2nd Workshop on Argumentation Mining. Stroudsburg, PA, USA: Association for Computational Linguistics, 2015. http://dx.doi.org/10.3115/v1/w15-0502.

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Khurana, Ishaan. "Asthma and genetics: Investigating nucleotide variants." In 2017 IEEE MIT Undergraduate Research Technology Conference (URTC). IEEE, 2017. http://dx.doi.org/10.1109/urtc.2017.8284184.

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"Cas9/gRNA-mediated modifications of the barley genome for fundamental and applied research." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Novosibirsk ICG SB RAS 2021, 2021. http://dx.doi.org/10.18699/plantgen2021-064.

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Smatti, Maria K., Yasser Al-Sarraj, Omar Albagha, and Hadi M. Yassine. "Host Genetic Variants Potentially Associated with SARS-Cov-2: A Multi-Population Analysis." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0298.

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Background: Clinical outcomes of Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and interpopulation differences, possibly due to host genetics differences. Earlier studies identified single nucleotide polymorphisms (SNPs) associated with SARS-CoV-1 in Eastern Asian (EAS) populations. In this report, we aimed at exploring the frequency of a set of genetic polymorphisms that could affect SARS-CoV-2 susceptibility or severity, including those that were previously associated with SARS-CoV-1. Methods: We extracted the list of SNPs that could potentially modulate SARS-CoV-2 from the genome wide association studies (GWAS) on SARS-CoV-1 and other viruses. We also collected the expression data of these SNPs from the expression quantitative trait loci (eQTLs) databases. Sequences from Qatar Genome Programme (QGP, n=6,054) and 1000Genome project were used to calculate and compare allelic frequencies (AF). Results: A total of 74 SNPs, located in 10 genes: ICAM3, IFN-γ, CCL2, CCL5, AHSG, MBL, Furin, TMPRSS2, IL4, and CD209 promoter, were identified. Analysis of Qatari genomes revealed significantly lower AF of risk variants linked to SARS-CoV-1 severity (CCL2, MBL, CCL5, AHSG, and IL4) compared to that of 1000Genome and/or the EAS population (up to 25-fold change). Conversely, SNPs in TMPRSS2, IFN-γ, ICAM3, and Furin were more common among Qataris (average 2-fold change). Inter-population analysis showed that the distribution of risk alleles among Europeans differs substantially from Africans and EASs. Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations. Conclusion: Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. Our results highlight the importance of exploring population genetics to understand and predict COVID-19 outcomes. Indeed, further studies are needed to validate these findings as well as to identify new genetic determinants linked to SARS-CoV-2.
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Verschuren, L. M. G., D. Schokker, S. Verstringe, L. Kruijt, A. A. C. de Wit, E. G. T. van der Valk, S. K. Kar, and E. D. Ellen. "502. Organoids as a research tool in animal breeding and nutrition." In World Congress on Genetics Applied to Livestock Production. The Netherlands: Wageningen Academic Publishers, 2022. http://dx.doi.org/10.3920/978-90-8686-940-4_502.

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Reports on the topic "Genetics – Research"

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Villa-Cuesta, Eugenia, and Lawrence Hobbie. Genetics Research Project Laboratory: A Discovery-Based Undergraduate Research Course. Genetics Society of America Peer-Reviewed Education Portal (GSA PREP), May 2016. http://dx.doi.org/10.1534/gsaprep.2016.003.

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Hayes, Jane L., and Kenneth F. Raffa. Proceedings of a workshop on bark beetle genetics: current status of research. Workshop on Bark Beetle Genetics; 1998 July 17-18; Madison, WI. Portland, OR: U.S. Department of Agriculture, Forest Service, Pacific Northwest Research Station, 1999. http://dx.doi.org/10.2737/pnw-gtr-466.

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Viskochil, David H., David Stevenson, and John Carey. The University of Utah Clinical Genetics Research Program as an NF1 Consortium Site. Fort Belvoir, VA: Defense Technical Information Center, February 2007. http://dx.doi.org/10.21236/ada465227.

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Sugarman, J. Accessible Genetics Research Ethics Education (AGREE): A Web-Based Program for IRBS and Investigators. Office of Scientific and Technical Information (OSTI), July 2004. http://dx.doi.org/10.2172/830022.

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McKenzie, Daniel. Liddle’s Syndrome: Literature Review of Genetics, Pathophysiology and the Future of Research and Potential Cure. Ames (Iowa): Iowa State University, January 2019. http://dx.doi.org/10.31274/cc-20240624-955.

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Zhang, Hongbin B., David J. Bonfil, and Shahal Abbo. Genomics Tools for Legume Agronomic Gene Mapping and Cloning, and Genome Analysis: Chickpea as a Model. United States Department of Agriculture, March 2003. http://dx.doi.org/10.32747/2003.7586464.bard.

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The goals of this project were to develop essential genomic tools for modern chickpea genetics and genomics research, map the genes and quantitative traits of importance to chickpea production and generate DNA markers that are well-suited for enhanced chickpea germplasm analysis and breeding. To achieve these research goals, we proposed the following research objectives in this period of the project: 1) Develop an ordered BAC library with an average insert size of 150 - 200 kb (USA); 2) Develop 300 simple sequence repeat (SSR) markers with an aid of the BAC library (USA); 3) Develop SSR marker tags for Ascochyta response, flowering date and grain weight (USA); 4) Develop a molecular genetic map consisting of at least 200 SSR markers (Israel and USA); 5) Map genes and QTLs most important to chickpea production in the U.S. and Israel: Ascochyta response, flowering and seed set date, grain weight, and grain yield under extreme dryland conditions (Israel); and 6) Determine the genetic correlation between the above four traits (Israel). Chickpea is the third most important pulse crop in the world and ranks the first in the Middle East. Chickpea seeds are a good source of plant protein (12.4-31.5%) and carbohydrates (52.4-70.9%). Although it has been demonstrated in other major crops that the modern genetics and genomics research is essential to enhance our capacity for crop genetic improvement and breeding, little work was pursued in these research areas for chickpea. It was absent in resources, tools and infrastructure that are essential for chickpea genomics and modern genetics research. For instance, there were no large-insert BAC and BIBAC libraries, no sufficient and user- friendly DNA markers, and no intraspecific genetic map. Grain sizes, flowering time and Ascochyta response are three main constraints to chickpea production in drylands. Combination of large seeds, early flowering time and Ascochyta blight resistance is desirable and of significance for further genetic improvement of chickpea. However, it was unknown how many genes and/or loci contribute to each of the traits and what correlations occur among them, making breeders difficult to combine these desirable traits. In this period of the project, we developed the resources, tools and infrastructure that are essential for chickpea genomics and modern genetics research. In particular, we constructed the proposed large-insert BAC library and an additional plant-transformation-competent BIBAC library from an Israeli advanced chickpea cultivar, Hadas. The BAC library contains 30,720 clones and has an average insert size of 151 kb, equivalent to 6.3 x chickpea haploid genomes. The BIBAC library contains 18,432 clones and has an average insert size of 135 kb, equivalent to 3.4 x chickpea haploid genomes. The combined libraries contain 49,152 clones, equivalent to 10.7 x chickpea haploid genomes. We identified all SSR loci-containing clones from the chickpea BAC library, generated sequences for 536 SSR loci from a part of the SSR-containing BACs and developed 310 new SSR markers. From the new SSR markers and selected existing SSR markers, we developed a SSR marker-based molecular genetic map of the chickpea genome. The BAC and BIBAC libraries, SSR markers and the molecular genetic map have provided essential resources and tools for modern genetic and genomic analyses of the chickpea genome. Using the SSR markers and genetic map, we mapped the genes and loci for flowering time and Ascochyta responses; one major QTL and a few minor QTLs have been identified for Ascochyta response and one major QTL has been identified for flowering time. The genetic correlations between flowering time, grain weight and Ascochyta response have been established. These results have provided essential tools and knowledge for effective manipulation and enhanced breeding of the traits in chickpea.
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Hayes, Jane L., and Jacqueline L. Robertson. Proceedings of a workshop on bark beetle genetics: current status of research. May 17-18, 1992, Berkeley, California. Albany, CA: U.S. Department of Agriculture, Forest Service, Pacific Southwest Research Station, 1992. http://dx.doi.org/10.2737/psw-gtr-138.

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Cahaner, Avigdor, Susan J. Lamont, E. Dan Heller, and Jossi Hillel. Molecular Genetic Dissection of Complex Immunocompetence Traits in Broilers. United States Department of Agriculture, August 2003. http://dx.doi.org/10.32747/2003.7586461.bard.

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Objectives: (1) Evaluate Immunocompetence-OTL-containing Chromosomal Regions (ICRs), marked by microsatellites or candidate genes, for magnitude of direct effect and for contribution to relationships among multiple immunocompetence, disease-resistance, and growth traits, in order to estimate epistatic and pleiotropic effects and to predict the potential breeding applications of such markers. (2) Evaluate the interaction of the ICRs with genetic backgrounds from multiple sources and of multiple levels of genetic variation, in order to predict the general applicability of molecular genetic markers across widely varied populations. Background: Diseases cause substantial economic losses to animal producers. Emerging pathogens, vaccine failures and intense management systems increase the impact of diseases on animal production. Moreover, zoonotic pathogens are a threat to human food safety when microbiological contamination of animal products occurs. Consumers are increasingly concerned about drug residues and antibiotic- resistant pathogens derived from animal products. The project used contemporary scientific technologies to investigate the genetics of chicken resistance to infectious disease. Genetic enhancement of the innate resistance of chicken populations provides a sustainable and ecologically sound approach to reduce microbial loads in agricultural populations. In turn, animals will be produced more efficiently with less need for drug treatment and will pose less of a potential food-safety hazard. Major achievements, conclusions and implications:. The PI and co-PIs had developed a refined research plan, aiming at the original but more focused objectives, that could be well-accomplished with the reduced awarded support. The successful conduct of that research over the past four years has yielded substantial new information about the genes and genetic markers that are associated with response to two important poultry pathogens, Salmonella enteritidis (SE) and Escherichia coli (EC), about variation of immunocompetence genes in poultry, about relationships of traits of immune response and production, and about interaction of genes with environment and with other genes and genetic background. The current BARD work has generated a base of knowledge and expertise regarding the genetic variation underlying the traits of immunocompetence and disease resistance. In addition, unique genetic resource populations of chickens have been established in the course of the current project, and they are essential for continued projects. The US laboratory has made considerable progress in studies of the genetics of resistance to SE. Microsatellite-marked chromosomal regions and several specific genes were linked to SE vaccine response or bacterial burden and the important phenomenon of gene interaction was identified in this system. In total, these studies demonstrate the role of genetics in SE response, the utility of the existing resource population, and the expertise of the research group in conducting such experiments. The Israeli laboratories had showed that the lines developed by selection for high or low level of antibody (Ab) response to EC differ similarly in Ab response to several other viral and bacterial pathogens, indicating the existence of a genetic control of general capacity of Ab response in young broilers. It was also found that the 10w-Ab line has developed, possibly via compensatory "natural" selection, higher cellular immune response. At the DNA levels, markers supposedly linked to immune response were identified, as well as SNP in the MHC, a candidate gene responsible for genetic differences in immunocompetence of chickens.
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Hovav, Ran, Peggy Ozias-Akins, and Scott A. Jackson. The genetics of pod-filling in peanut under water-limiting conditions. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597923.bard.

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Pod-filling, an important yield-determining stage is strongly influenced by water stress. This is particularly true for peanut (Arachishypogaea), wherein pods are developed underground and are directly affected by the water condition. Pod-filling in peanut has a significant genetic component as well, since genotypes are considerably varied in their pod-fill (PF) and seed-fill (SF) potential. The goals of this research were to: Examine the effects of genotype, irrigation, and genotype X irrigation on PF and SF. Detect global changes in mRNA and metabolites levels that accompany PF and SF. Explore the response of the duplicate peanut pod transcriptome to drought stress. Study how entire duplicated PF regulatory processes are networked within a polyploid organism. Discover locus-specific SNP markers and map pod quality traits under different environments. The research included genotypes and segregating populations from Israel and US that are varied in PF, SF and their tolerance to water deficit. Initially, an extensive field trial was conducted to investigate the effects of genotype, irrigation, and genotype X irrigation on PF and SF. Significant irrigation and genotypic effect was observed for the two main PF related traits, "seed ratio" and "dead-end ratio", demonstrating that reduction in irrigation directly influences the developing pods as a result of low water potential. Although the Irrigation × Genotype interaction was not statistically significant, one genotype (line 53) was found to be more sensitive to low irrigation treatments. Two RNAseq studies were simultaneously conducted in IL and the USA to characterize expression changes that accompany shell ("source") and seed ("sink") biogenesis in peanut. Both studies showed that SF and PF processes are very dynamic and undergo very rapid change in the accumulation of RNA, nutrients, and oil. Some genotypes differ in transcript accumulation rates, which can explain their difference in SF and PF potential; like cvHanoch that was found to be more enriched than line 53 in processes involving the generation of metabolites and energy at the beginning of seed development. Interestingly, an opposite situation was found in pericarp development, wherein rapid cell wall maturation processes were up-regulated in line 53. Although no significant effect was found for the irrigation level on seed transcriptome in general, and particularly on subgenomic assignment (that was found almost comparable to a 1:1 for A- and B- subgenomes), more specific homoeologous expression changes associated with particular biosynthesis pathways were found. For example, some significant A- and B- biases were observed in particular parts of the oil related gene expression network and several candidate genes with potential influence on oil content and SF were further examined. Substation achievement of the current program was the development and application of new SNP detection and mapping methods for peanut. Two major efforts on this direction were performed. In IL, a GBS approach was developed to map pod quality traits on Hanoch X 53 F2/F3 generations. Although the GBS approach was found to be less effective for our genetic system, it still succeeded to find significant mapping locations for several traits like testa color (linkage A10), number of seeds/pods (A5) and pod wart resistance (B7). In the USA, a SNP array was developed and applied for peanut, which is based on whole genome re-sequencing of 20 genotypes. This chip was used to map pod quality related traits in a Tifrunner x NC3033 RIL population. It was phenotyped for three years, including a new x-ray method to phenotype seed-fill and seed density. The total map size was 1229.7 cM with 1320 markers assigned. Based on this linkage map, 21 QTLs were identified for the traits 16/64 weight, kernel percentage, seed and pod weight, double pod and pod area. Collectively, this research serves as the first fundamental effort in peanut for understanding the PF and SF components, as a whole, and as influenced by the irrigation level. Results of the proposed study will also generate information and materials that will benefit peanut breeding by facilitating selection for reduced linkage drag during introgression of disease resistance traits into elite cultivars. BARD Report - Project4540 Page 2 of 10
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Zhang, Hongbin, Shahal Abbo, Weidong Chen, Amir Sherman, Dani Shtienberg, and Frederick Muehlbauer. Integrative Physical and Genetic Mapping of the Chickpea Genome for Fine Mapping and Analysis of Agronomic Traits. United States Department of Agriculture, March 2010. http://dx.doi.org/10.32747/2010.7592122.bard.

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Chickpea is the third most important pulse crop in the world and ranks first in the Middle East; however, it has been subjected to only limited research in modern genomics. In the first period of this project (US-3034-98R) we constructed two large-insert BAC and BIBAC libraries, developed 325 SSR markers and mapped QTLs controlling ascochyta blight resistance (ABR) and days to first flower (DTF). Nevertheless, the utilities of these tools and results in gene discovery and marker-assisted breeding are limited due to the absence of an essential platform. The goals of this period of the project were to use the resources and tools developed in the first period of the project to develop a BAC/BIBAC physical map for chickpea and using it to identify BAC/BIBACcontigs containing agronomic genes of interest, with an emphasis on ABR and DTF, and develop DNA markers suitable for marker-assisted breeding. Toward these goals, we proposed: 1) Fingerprint ~50,000 (10x) BACs from the BAC and BIBAC libraries, assemble the clones into a genome-wide BAC/BIBAC physical map, and integrate the BAC/BIBAC map with the existing chickpea genetic maps (Zhang, USA); 2) fine-map ABR and DTFQTLs and enhance molecular tools for chickpea genetics and breeding (Shahal, Sherman and DaniShtienberg, Israel; Chen and Muehlbauer; USA); and 3) integrate the BAC/BIBAC map with the existing chickpea genetic maps (Sherman, Israel; Zhang and Chen, USA). For these objectives, a total of $460,000 was requested originally, but a total of $300,000 was awarded to the project. We first developed two new BAC and BIBAC libraries, Chickpea-CME and Chickpea- CHV. The chickpea-CMEBAC library contains 22,272 clones, with an average insert size of 130 kb and equivalent to 4.0 fold of the chickpea genome. The chickpea-CHVBIBAC library contains 38,400 clones, with an average insert size of 140 kb and equivalent to 7.5 fold of the chickpea genome. The two new libraries (11.5 x), along with the two BAC (Chickpea-CHI) and BIBAC (Chickpea-CBV) libraries (7.1 x) constructed in the first period of the project, provide libraries essential for chickpea genome physical mapping and many other genomics researches. Using these four libraries we then developed the proposed BAC/BIBAC physical map of chickpea. A total of 67,584 clones were fingerprinted, and 64,211 (~11.6 x) of the fingerprints validated and used in the physical map assembly. The physical map consists of 1,945 BAC/BIBACcontigs, with each containing an average of 39.2 clones and having an average physical length of 559 kb. The contigs collectively span ~1,088 Mb, being 1.49 fold of the 740- Mb chickpea genome. Third, we integrated the physical map with the two existing chickpea genetic maps using a total of 172 (124 + 48) SSR markers. Fourth, we identified tightly linked markers for ABR-QTL1, increased marker density at ABR-QTL2 and studied the genetic basis of resistance to pod abortion, a major problem in the east Mediterranean, caused by heat stress. Finally, we, using the integrated map, isolated the BAC/BIBACcontigs containing or closely linked to QTL4.1, QTL4.2 and QTL8 for ABR and QTL8 for DTF. The integrated BAC/BIBAC map resulted from the project will provide a powerful platform and tools essential for many aspects of advanced genomics and genetics research of this crop and related species. These includes, but are not limited to, targeted development of SNP, InDel and SSR markers, high-resolution mapping of the chickpea genome and its agronomic genes and QTLs, sequencing and decoding of all genes of the genome using the next-generation sequencing technology, and comparative genome analysis of chickpea versus other legumes. The DNA markers and BAC/BIBACcontigs containing or closely linked to ABR and DTF provide essential tools to develop SSR and SNP markers well-suited for marker-assisted breeding of the traits and clone their corresponding genes. The development of the tools and knowledge will thus promote enhanced and substantial genetic improvement of the crop and related legumes.
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