Academic literature on the topic 'Genetics and Genome Biology'
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Journal articles on the topic "Genetics and Genome Biology"
Pennisi, E. "Genetics: From Genes to Genome Biology." Science 272, no. 5269 (June 21, 1996): 1736–38. http://dx.doi.org/10.1126/science.272.5269.1736.
Full textPegoraro, Mirko, and Gareth D. Weedall. "Malaria in the ‘Omics Era’." Genes 12, no. 6 (May 30, 2021): 843. http://dx.doi.org/10.3390/genes12060843.
Full textSmýkal, P. "Pea (Pisum sativum L.) in biology prior and after Mendel's discovery." Czech Journal of Genetics and Plant Breeding 50, No. 2 (June 12, 2014): 52–64. http://dx.doi.org/10.17221/2/2014-cjgpb.
Full textTeterina, Anastasia A., John H. Willis, and Patrick C. Phillips. "Chromosome-Level Assembly of the Caenorhabditis remanei Genome Reveals Conserved Patterns of Nematode Genome Organization." Genetics 214, no. 4 (February 28, 2020): 769–80. http://dx.doi.org/10.1534/genetics.119.303018.
Full textBeacon, Tasnim H., James R. Davie, and Michael J. Hendzel. "Introduction: Genome Biology." Genome 64, no. 4 (April 2021): v—vii. http://dx.doi.org/10.1139/gen-2021-0003.
Full textTotikov, Azamat, Andrey Tomarovsky, Dmitry Prokopov, Aliya Yakupova, Tatiana Bulyonkova, Lorena Derezanin, Dmitry Rasskazov, et al. "Chromosome-Level Genome Assemblies Expand Capabilities of Genomics for Conservation Biology." Genes 12, no. 9 (August 28, 2021): 1336. http://dx.doi.org/10.3390/genes12091336.
Full textBult, C. J. "The Mouse Genome Database (MGD): integrating biology with the genome." Nucleic Acids Research 32, no. 90001 (January 1, 2004): 476D—481. http://dx.doi.org/10.1093/nar/gkh125.
Full textShiloh, Y. "Cancer genetics: Tumor biology and genome technology converge." European Journal of Cancer 29 (January 1993): S9. http://dx.doi.org/10.1016/0959-8049(93)90650-5.
Full textWixon, Jo. "Meeting Highlights: Genome Sequencing and Biology 2001." Comparative and Functional Genomics 2, no. 4 (2001): 243–51. http://dx.doi.org/10.1002/cfg.97.
Full textSung, Bong Hyun, Donghui Choe, Sun Chang Kim, and Byung-Kwan Cho. "Construction of a minimal genome as a chassis for synthetic biology." Essays in Biochemistry 60, no. 4 (November 30, 2016): 337–46. http://dx.doi.org/10.1042/ebc20160024.
Full textDissertations / Theses on the topic "Genetics and Genome Biology"
Chew, Wei Leong. "Postnatal Genome Editing With CRISPR." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493352.
Full textMedical Sciences
Omilian, Angela Ruggieri. "Features of Daphnia genome evolution." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3243783.
Full textTitle from PDF t.p. (viewed Nov. 18, 2008). Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 6862. Adviser: Michael Lynch.
Chung, Hattie. "Genome evolution in structured systems." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493565.
Full textSystems Biology
Chen, Stacy Yen-chun. "Genome-wide analysis of yeast meiotic recombination landscape." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390037.
Full textSimonson, Matthew A. "Polygenic analysis of genome-wide SNP data." Thesis, University of Colorado at Boulder, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3562047.
Full textOne of the central motivators behind genetic research is to understand how genetic variation relates to human health and disease. Recently, there has been a large-scale effort to find common genetic variants associated with many forms of disease and disorder using single nucleotide polymorphisms (SNPs). Several genome-wide association (GWAS) studies have successfully identified SNPs associated with phenotypes. However, the effect sizes attributed to individual variants is generally small, explaining only a very small amount of the genetic risk and heritability expected based on the estimates of family and twin studies. Several explanations exist for the inability of GWAS to find the "missing heritability."
The results of recent research appear to confirm the prediction made by population genetics theory that most complex phenotypes are highly polygenic, occasionally influenced by a few alleles of relatively large effect, and usually by several of small effect. Studies have also confirmed that common variants are only part of what contributes to the total genetic variance for most traits, indicating rare-variants may play a significant role.
This research addresses some of the most glaring weaknesses of the traditional GWAS approach through the application of methods of polygenic analysis. We apply several methods, including those that investigate the net effects of large sets of SNPs, more sophisticated approaches informed by biology rather than the purely statistical approach of GWAS, as well as methods that infer the effects of recessive rare variants.
Our results indicate that traditional GWAS is well complemented and improved upon by methods of polygenic analysis. We demonstrate that polygenic approaches can be used to significantly predict individual risk for disease, provide an unbiased estimate of a substantial proportion of the heritability for multiple phenotypes, identify sets of genes grouped into biological pathways that are enriched for associations, and finally, detect the significant influence of recessive rare variants.
Wesolowska, Natalia. "Modification and nuclear organization of the Drosophila melanogaster genome." Thesis, The Johns Hopkins University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3575013.
Full textThe success of Drosophila as a system for genetic analysis is closely linked to its amenability to genetic manipulation. Part 1 of the dissertation elucidates a novel scheme for long-range targeted manipulation of genes. We integrated an 80-kb genomic fragment at its endogenous locus, utilizing a targeted attP attachment site for the phiC31 integrase. We achieved single-copy reduction of the resulting region duplication by inducing recombinational DNA repair. We showed that this two-step scheme of integration and reduction is efficient and useful for delivering modifications. We established a vector configuration that facilitates the recovery of modifications. The integrating genomic fragment allowed for delivery of a new attachment site at 70 kb from the existing attP into a new locus, making it susceptible to targeted mutagenesis. We extrapolate that with this scheme, only 1 200 lines bearing att-sites throughout the genome would suffice to render all Drosophila genes amenable to targeted mutagenesis. Excitingly, this method should be readily applicable to other systems.
In Part 2 of the dissertation, I explored the question of telomere organization in Drosophila. Telomeres demarcate the ends of linear chromosomes to distinguish them from broken ends. In yeast, they cluster at the periphery of the nucleus establishing a compartment of silent chromatin. To bring insight into telomere organization in a higher organism, we followed EGFPlabeled Drosophila telomeric protein HOAP in vivo and found that the 16 telomeres cluster into 4-6 foci per nucleus in somatic tissues. Interestingly, HOAP signal intensity in the clusters doubles in interphase, potentially due to loading of HOAP to newly replicated telomeres. We tested several predictions about rules governing clustering. First, by inspecting mutant embryos that develop as haploids, we found that clustering is not mediated by associations between homologs. Second, by demonstrating clustering capability for a telomere of novel sequence, we eliminated DNA sequence homology and identity as important factors. Third, by marking both ends of a chromosome, we ruled out predominance of intra-chromosomal interactions. We propose that clustering is indiscriminate of sequence and is likely maintained by a yet undetermined factor.
Badhwar, AmanPreet. "Identification and characterization of rearrangements in the vervet monkey genome." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101702.
Full textTo study the evolutionary dynamics of centromere formation, I identified and validated the alpha-satellite repeat as a centromere-specific marker in the vervet using comparative genomics, sequence analysis and hybridization screening. I developed criteria to infer the position of vervet bacterial artificial chromosome (BAC) inserts based on alpha-satellite monomer content. In a complementary approach, I demarcated the pericentromeric boundaries in human and identified vervet BAC clones that mapped orthologously to these regions.
In addition to centromeric analyses, I developed methodologies to detect other genome rearrangements, in particular vervet deletion/human insertion and vervet translocation events. The tools and approaches developed in this thesis will prove useful in cataloguing additional vervet genome rearrangements.
Young, Adrian. "The Evolutionary Feedback between Genetic Conflict and Genome Architecture." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11482.
Full textLi, Hubo. "Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226105.
Full textCanver, Matthew. "Elucidation of Mechanisms of Fetal Hemoglobin Regulation by CRISPR/Cas9 Mediated Genome Editing." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493407.
Full textMedical Sciences
Books on the topic "Genetics and Genome Biology"
Post-genome biology of primates. Tokyo: Springer, 2012.
Find full textIgor, Kovalchuk, and Kovalchuk Olga MD, eds. Transgenerational genome instability. Hauppauge, N.Y: Nova Science Publishers, 2009.
Find full textEvolution, development, & the predictable genome. Greenwood Village, Colo: Roberts And Company Publishers, 2011.
Find full text1944-, Adolph Kenneth W., ed. Human genome methods. Boca Raton: CRC Press, 1998.
Find full textGenome instability and transgenerational effects. New York: Nova Science Publishers, 2010.
Find full text1966-, Muse Spencer V., ed. A primer of genome science. 3rd ed. Sunderland, Mass: Sinauer Associates, 2009.
Find full textStrachan, T. Human molecular genetics. 4th ed. New York: Garland Science, 2011.
Find full textG, Zimm Georgianna, and Lindsley Dan L. 1925-, eds. The genome of Drosophila melanogaster. San Diego: Academic Press, 1992.
Find full textLewontin, Richard C. It ain't necessarily so: The dream of the human genome and other illusions. London: Granta, 2001.
Find full textS, Rajadhyaksha Medha, ed. New biology and genetic diseases. New Delhi: Oxford University Press, 1999.
Find full textBook chapters on the topic "Genetics and Genome Biology"
Van Asselt, Austin J., and Erik A. Ehli. "Whole-Genome Genotyping Using DNA Microarrays for Population Genetics." In Methods in Molecular Biology, 269–87. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1920-9_16.
Full textMoore, Graham. "Exploiting Comparative Biology and Genomics to Understand a Trait in Wheat, Ph1." In Advances in Wheat Genetics: From Genome to Field, 137–46. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55675-6_15.
Full textDahiya, Rashmi, Taj Mohammad, and Md Imtaiyaz Hassan. "Role of Genome-Wide Association Studies in Host Genetics: Toward Understanding of Microbiome Association." In Metagenomic Systems Biology, 37–54. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8562-3_2.
Full textKobayashi, Ichizo. "Genetic Addiction: a Principle of Gene Symbiosis in a Genome." In Plasmid Biology, 105–44. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817732.ch6.
Full textMaliga, Pal, and Zora Svab. "Engineering the Plastid Genome of Nicotiana sylvestris, a Diploid Model Species for Plastid Genetics." In Methods in Molecular Biology, 37–50. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-61737-957-4_2.
Full textObata, Masaomi, Mareki Ohtsuji, Yukiyasu Iida, Toshikazu Shirai, Sachiko Hirose, and Hioroyuki Nishimura. "Genome-Wide Genetic Study in Autoimmune Disease-Prone Mice." In Methods in Molecular Biology, 111–41. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0404-4_13.
Full textJohansson, Anna C. V., and Lars Feuk. "Characterizing and Interpreting Genetic Variation from Personal Genome Sequencing." In Methods in Molecular Biology, 343–67. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-507-7_17.
Full textHill, Eric M., Cheng-Yi Chen, Florencia del Viso, Lacey R. Ellington, Shuonan He, Ahmet Karabulut, Ariel Paulson, and Matthew C. Gibson. "Manipulation of Gene Activity in the Regenerative Model Sea Anemone, Nematostella vectensis." In Methods in Molecular Biology, 437–65. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2172-1_23.
Full textDeleye, Lieselot, Dieter De Coninck, Dieter Deforce, and Filip Van Nieuwerburgh. "Genome-Wide Copy Number Alteration Detection in Preimplantation Genetic Diagnosis." In Methods in Molecular Biology, 27–42. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7514-3_3.
Full textMeyer-Ficca, Mirella L., and Ralph G. Meyer. "Genetic Approaches to Targeting Multiple PARP Genes in a Mammalian Genome." In Methods in Molecular Biology, 349–76. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-270-0_21.
Full textConference papers on the topic "Genetics and Genome Biology"
"NGRI1, PIP4K2A, and HTR2K contain possible genetics." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-408.
Full text"Mitochondrial genetics of amphipods: revealing mechanisms of diversity." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-153.
Full text"Understanding the role of genetics in comorbidity." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-220.
Full text"Fundamental and applied aspects of microbiome genetics." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-277.
Full text"Seeking an optimal approach to variant calling in medical genetics." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-215.
Full text"766 BGRS/SB-2022 Medical genetics and cancer studies based on next-gen sequencing presented at the bioinformatics conferences and young scientists schools." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-442.
Full text"Genetic regulation of wheat inflorescence development." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-191.
Full textKim, Moon K., Byeongsoo Lim, and Wing Kam Liu. "Multiscale Elastic Network Model for Macromolecular Machines." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13090.
Full text"Genetic aspects of internet-dependence in teenagers." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-160.
Full text"Inter- vs. intraspecific genetic variability of morphologically similar Ligophorus species." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-166.
Full textReports on the topic "Genetics and Genome Biology"
Dawson, William O., Moshe Bar-Joseph, Charles L. Niblett, Ron Gafny, Richard F. Lee, and Munir Mawassi. Citrus Tristeza Virus: Molecular Approaches to Cross Protection. United States Department of Agriculture, January 1994. http://dx.doi.org/10.32747/1994.7570551.bard.
Full textKonisky, J. Genetics and molecular biology of methanogen genes. Final report. Office of Scientific and Technical Information (OSTI), October 1997. http://dx.doi.org/10.2172/555346.
Full textPalsson, Bernhard O., Ali Ebrahim, and Steve Federowicz. The OME Framework for genome-scale systems biology. Office of Scientific and Technical Information (OSTI), December 2014. http://dx.doi.org/10.2172/1169326.
Full textGunsalus, R. P. Molecular biology and genetics of the acetate-utilizing methanogenic bacteria. Office of Scientific and Technical Information (OSTI), January 1991. http://dx.doi.org/10.2172/6967641.
Full textRobert P. Gunsalus. Molecular Biology and Genetics of the Acetate-Utilizing Methanogenic Bacteria. Office of Scientific and Technical Information (OSTI), July 2003. http://dx.doi.org/10.2172/859404.
Full textBoore, Jeffrey. Why Evolutionary Biology and Genome Sciences Need Each Other. Office of Scientific and Technical Information (OSTI), May 2005. http://dx.doi.org/10.2172/840341.
Full textMoore, Gloria A., Gozal Ben-Hayyim, Charles L. Guy, and Doron Holland. Mapping Quantitative Trait Loci in the Woody Perennial Plant Genus Citrus. United States Department of Agriculture, May 1995. http://dx.doi.org/10.32747/1995.7570565.bard.
Full textWall, Judy D. Genetics and Molecular Biology of Hydrogen Metabolism in Sulfate-Reducing Bacteria. Office of Scientific and Technical Information (OSTI), December 2014. http://dx.doi.org/10.2172/1166017.
Full textWall, J. Genetics and molecular biology of hydrogen metabolism in sulfate reducing bacteria. Office of Scientific and Technical Information (OSTI), January 1990. http://dx.doi.org/10.2172/6892389.
Full textWisniewski, Michael E., Samir Droby, John L. Norelli, Noa Sela, and Elena Levin. Genetic and transcriptomic analysis of postharvest decay resistance in Malus sieversii and the characterization of pathogenicity effectors in Penicillium expansum. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7600013.bard.
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