Dissertations / Theses on the topic 'Genetic screening – Psychological aspects'
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Lesniak, Karen. "Psychological and Sociodemographic Predictors of Psychological Distress in BRCA1 and BRCA2 Genetic Testing Participants within a Community Based Genetic Screening Program." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2565/.
Full textKeenan, Lisa A. "Family Environment, Social Support, and Psychological Distress of Women Seeking BRCA1 and BRCA2 Genetic Mutation Testing." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3240/.
Full textElliott, Diana. "The impact of genetic counselling for familial breast cancer on women's psychological distress, risk perception and understanding of BRCA testing." University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0190.
Full textSteggles, Naomi. "Psychological aspects of genetic testing for cancer." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271020.
Full textMarerro, Magaly V. (Magaly Victoria). "Primary Care Screening for Psychological Factors." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331793/.
Full textLau, Yvonne, and n/a. "The enthusiasm for disease screening : an ethical critique with a sociological perspective." University of Otago. Dunedin School of Medicine, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090121.085918.
Full textTedgård, Ulf. "Prenatal diagnosis of haemophilia psychological, social and ethical aspects /." Malmö : Dept. of Pediatrics, University Hospital of Malmö, University of Lund, 1999. http://catalog.hathitrust.org/api/volumes/oclc/57455671.html.
Full text馮敬業 and King-yip Fung. "Screening of recurrent BRCA gene mutations in Chinese breast and ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969720.
Full textHayat, Roshanai Afsaneh. "Psychological and Behavioral Aspects of Receiving Genetic Counseling for Hereditary Cancer." Doctoral thesis, Uppsala universitet, Vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128870.
Full textNg, Wai-tong, and 吳偉棠. "Early detection and screening of familial nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290720.
Full textWilliamson, Nancy D. "Psychological Responses of Fathers and Mothers to Amniocentesis." Master's thesis, University of Central Florida, 1985. http://digital.library.ucf.edu/cdm/ref/collection/RTD/id/15675.
Full textAmniocentesis is one of the most widely used prenatal diagnostic techniques for congenital disorders. It was hypothesized that the spychological responses of mothers and fathers to amniocenthesis during high-rish pregnancies would be positively correlated on scales of Symptomatology (Anxiety, Depression, Anger, and Somatic Complaints) and Well-Being (Relaxed, Contented, Friendliness, and Somatic Well-Being). It was also hypothesized that Symptomatology would be negatively correlated with Well-Being. Nineteen couples, who were referred by their physicians, voluntarily participated in the study. Each partner completed the Symptom Questionnaire (Kellner, 1983), a self-rating scale of Symptomatology and Well-Being, in addition to the Pre-Amniocentesis and Post-Amniocentesis Questionnaires (original questionnaires developed for this study) at intervals prior to and following the procedure, while awaiting results. A Pearson product-moment correlation of the total scores revealed a positive correlation (p < 0.5) between the scores of fathers and mothers on the Symptomatology Scale, both pre- and post-amniocentesis (r = .47 and .47). In addition, there was a significant negative correlation (p < .05) between Symptomatolgy and Well-Being scores for both mothers (r = -.55 and -.60) and fathers (r = -.48 and -.74) at the pre- and post-amniocentesis periods, respectively. The hypothesis cannot be completely accepted because the positive correlation does not exist at the post-amniocentesis level. Mothers appear to experience more Symptomatology and less Well-Being than fathers at the post-amniocentesis level. The results are interpreted to suggest that fathers and mothers may both benefit from pre- and post-amniocentesis supportive intervention.
M.S.;
Masters
Arts and Sciences;
Clinical Psychology;
42 p.
vii, 42 leaves, bound : ill. ; 28 cm.
Hoek, Kim G. P. "Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR)." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/2834.
Full textPre-eclampsia is a multisystemic disorder with an incidence of ~6-8% in non-Caucasian women in the Western Cape. Trophoblast invasion is vital for adequate anchorage of the placenta to the uterine wall as well as for the optimisation of utero-placental blood flow in uncomplicated pregnancies. This process is facilitated by the fetal trophoblast cells that digest the extracellular matrix of the uterus by secreting various molecules, including the metalloproteinases (MMP), of which MMP-9 has an increased production during the first trimester. Leptin, an autocrine regulator of MMP-9 secretion, functions via the leptin receptor to prevent over-invasion of maternal tissues. The aim of this study was to investigate the role of the leptin (ob) and leptin receptor (obR) genes in predisposition to pre-eclampsia and involved screening the genes in South African non-Caucasian cohorts and performing statistical analysis to determine whether any variants contributed to the disease profile.
Siu, Ho-yee Vivian. "The role of monitoring style in managing psychological distress associated with genetic colorectal cancer testing." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29760161.
Full textGustafsson, Stolt Ulrica. "Aspects in bioethics : theory and practice in a preventive screening for type 1 diabetes /." Linköping, 2002. http://www.bibl.liu.se/liupubl/disp/disp2003/med763s.pdf.
Full textWade, Walsh Margo. "Women Receiving Genetic Counseling for Breast Cancer Risk: Cancer Worry, Psychological Distress, and Risk Recall Accuracy." Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc2185/.
Full textMarino, Dante. "Screening of Germplasm Accessions from the Brassica Species for Resistance against PG3 and PG4 Isolates of Blackleg." Thesis, North Dakota State University, 2011. https://hdl.handle.net/10365/29053.
Full textNorth Dakota State University. Department of Plant Pathology
USDA North Central Canola Research Program
Northern Canola Growers Association
Makubalo, Zola. "Mutation screening of candidate genes and the development of polymorphic markers residing on chromosome 19q13.3, the progressive familial heart block I gene search area." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51838.
Full textENGLISH ABSTRACT: Progressive familial heart block type I (PFHBI) is a cardiac ventricular conduction disorder of unknown cause associated with risk of sudden death, which has been described in several South African families. Clinically, PFHBI is characterised by right bundle branch block on ECG, which may progress to complete heart block, necessitating pacemaker implantation. The disease shows an autosomal dominant pattern of inheritance with evidence of genetic anticipation. Using genetic linkage analysis, the PFHBI-causative gene was mapped to a 10 eentimorgan (cM) gene-rich area of chromosome (C) 19q13.3, which has, subsequently, been reduced to 7cM by fine mapping with polymorphic dinucleotide (CA)n short tandem repeat (STR) markers. Several attractive candidate genes, including muscle glycogen synthase (GSY 1) and histidine-rich calcium binding protein (HRC), lie within this region. The aim of the present study was two-fold: 1) to identify and characterise tetranucleotide (AAAT)n STRs within the PFHBI critical region that could be developed as polymorphic markers for use in genetic fine mapping and 2) to screen selected regions of GSY 1and HRC, positional candidate genes, for the presence ofPFHBI-causing mutation(s). Cosmids harbouring CI9q13.3 insert DNA were screened for the presence of (AAAT)n STRs by dot blot and Southern blot hybridisation using a radiolabelled (AAAT)lO oligonucleotide probe. To characterise the harboured (AAAT)n STRs, the positively hybridising fragments identified by Southern blot were sub-cloned, sequenced and primers designed from the unique repeat-flanking sequences. These primers were used to genotype the (AAAT)n repeat locus to assess its polymorphic nature in a panel of unrelated individuals. Alternatively, vectorette PCR, a rapid method of identifying repeat sequences and obtaining the flanking sequences in large inserts, was employed to develop polymorphic markers from the positively hybridising clones. Selected exons of GSY1 and HRC were screened for the presence of potentially disease-causing mutations by PCR-SSCP analysis and direct sequencing, respectively, in PFHBI-affected and unaffected family members. Of the available cosmid clones that gave strong signals on dot blot and Southern blot hybridisation, three, 29395, 24493 and 20381, were located within the critical PFHBI area and were used for marker development. An interrupted (AAAT)n repeat motif (n less than 5) was identified in cosmid 29395, however, the repeat locus was not polymorphic in the tested population. No (AAAT)n motif, single or repeated was observed in the partial sequence of the sub-cloned fragment of cosmid 24493. Using vectorette peR, no repeated (AAAT)n motif was identified on sequencing the generated products in either cosmid 24493 or 2038l. However, diffuse single AAAT motifs were detected in both cosmids. Exons 4, 5, 11, 12 and 16 of GSY 1, containing domains that are conserved across species, and the conserved eterminus- encoding exons 2-6 of HRC were selected for screening for potential PFHBI-causing mutation(s). However, no sequence variations were detected. The interrupted (AAAT)n repeat identified in cosmid 29395 was not polymorphic, which confirmed reports that complex repeats, especially those containing AAAT motifs of less than 6 repeats, are not polymorphic. One possible explanation for the absence of a repeated AAAT motif in cosmids 24493 and 20381, which both gave positive hybridisation signals, is that the low annealing temperature of the AfT -rich repeat-anchored primers used in vectorette peR may have resulted in transient annealing to the diffuse single AAAT motifs detected on sequencing. The screened regions of candidate genes GSYI and HRC were excluded from carrying the disease-causing mutation(s). The availability of new sequence data generated by the Human Genome Project will influence future strategies to identify the PFHBI gene. Electronic searches will allow identification of STR sequences for development of polymorphic markers and gene annotation will allow selection of new candidate genes for mutation screening.
AFRIKAANSE OPSOMMING: Sien volteks vir opsomming
Kirkendall, Darrin J. "The relationship between anxiety and children's performance on the Reitan-Indiana Aphasia Screening Test." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1063209.
Full textDepartment of Educational Psychology
Gebhardt, G. S. "Genetic aspects of pre-eclampsia : mutation screening of the low-density lipoprotein receptor, methylenetetrahydrofolate reductase, prothrombin and factor V candidate genes." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52284.
Full textENGLISH ABSTRACT: Pre-eclampsia is a condition unique to pregnancy and primarily affects the maternal and placental vascular endothelium. It has significant morbidity and mortality consequences for both mother and infant. Despite global research into the aetiology of the condition, the cause for this condition remains unknown. Several factors, including a strong family history of hypertension in pregnancy point to a familial or genetic component in the pathophysiology of this complication. The purpose of this research project was to investigate candidate genes implicated in endothelial damage. Common methylene-tetra-hydrofolate reductase (MTHFR) gene mutations C677T and A1298C, factor V Leiden mutation R506Q and prothrombin mutation A20210G were investigated in 50 patients with an uncomplicated pregnancy outcome (controls) and 350 patients with various clinical manifestations of preeclampsia, including severe, early onset forms and abruptio placentae. Fasting homocystein levels were determined biochemically on all participants. In addition, 126 consecutive pregnant patients were recruited at booking, fasting lipograms were performed on them as well as mutation screening of 7 common mutations in the low-density lipoprotein receptor gene. This was correlated with eventual pregnancy outcome, and those with an uncomplicated outcome were selected as an additional control group. A significant association between hyperhomocysteinaemia and early onset severe pre-eclampsia could be demonstrated. Mutant allele T of the C677T mutation could be associated with hyperhomocysteinaemia but not with pre-eclampsia whilst mutant allele C of mutation A1298C demonstrated a significant correlation with diastolic blood pressure. In addition, combined heterozygosity for these mutations may serve as a marker for abruptio placentae.
ENGLISH ABSTRACT: Pre-eklampsie is 'n hipertensiewe toestand uniek aan menslike swangerskap en dit affekteer hoofsaaklik die vaskulêre endoteel. Die toestand hou ernstige morbiditeit en mortaliteit vir beide ma en baba in en na jare se navorsing is die oorsaak van hierdie toestand steeds onbekend. Epidemiologiese studies toon 'n duidelike familiële verband aan wat die vermoede laat ontstaan dat daar 'n onderliggende genetiese aspek tot die ontwikkeling van die siektetoestand is. Die doel van hierdie navorsingsprojek was om gene te ondersoek wat geïmpliseer word in endoteel skade. Twee algemene mutasies, C677T en A1298C in die MTHFR geen asook faktor V Leiden R506Q en protrombien A20210G mutasies is ontleed in 50 pasiënte met 'n ongekompliseerde swangerskapsverloop en in 350 pasiënte met 'n swangerskap gekompliseer deur verskillende kliniese manifestasies van die siekteproses, insluitende vroeë aankoms erge pre-eklampsie en abruptio placentae. Op alle pasiënte is ook 'n vastende homosistiën vlak biochemies bepaal. 'n Verdere 126 opeenvolgende pasiënte is gewerf tydens hulle eerste besoek aan die voorgeboortekliniek en vastende lipogramme is op almal uitgevoer. Mutasie sifting vir 7 algemene mutasies in die lae-digtheids lipoproteïen reseptor geen is op hierdie groep gedoen en die resultaat is met die uiteindelike swangerskapsuitkoms gekorreleer. Pasiënte met 'n uitkoms ongekompliseer deur hipertensie is gekies om deel te wees van 'n verdere kontrolegroep. Daar was 'n betekenisvolle verband tussen hiperhomositiënemie en erge, vroeë aankoms pre-eklampsie. Die T alleel van die C677T mutasie is geassosieer met hiperhomosistiënemie maar nie met pre-eklampsie nie. Die C alleel van die A 1298C mutasie toon 'n betekenisvolle verband met diastoliese bloeddruk. Gekombineerde heterosigositeit vir beide MTHFR mutasies kan 'n moontlike merker vir abruptio placentae wees.
Feinstein, Carla Fran. "Dying to Know." PDXScholar, 2010. https://pdxscholar.library.pdx.edu/open_access_etds/1318.
Full textDu, Min. "A greenhouse screening method for resistance to gray leaf spot in maize." Thesis, Virginia Tech, 1993. http://hdl.handle.net/10919/42953.
Full textWalker, Katherine Elise. "Correlates of the Scales of a Modified Screening Version of the Multidimensional Pain Inventory with Depression and Anxiety on a Chronic Pain Sample." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc9822/.
Full textPanton, Nicola. "Mutation analysis of four genes implicated in iron homeostasis in porphyria cutanea tarda (PCT) patients." Thesis, Link to the online version, 2008. http://hdl.handle.net/10019/888.
Full textDelport, Darnielle. "The development and application of a polymerase chain reaction (PCR) based assay to determine the impact of genetic variation in South African patients diagnosed with depression." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86564.
Full textENGLISH ABSTRACT: Major Depressive Disorder (MDD) is a severe debilitating medical condition that may lead to suicide. Due to a poor understanding of the biological mechanisms underlying the disease process therapeutic decisions are usually taken using a ‘trial and error’ approach. This is not ideal since many treatments do not work as expected for all individuals. Studies have shown that only half of MDD patients receive the appropriate treatment, whereas many patients have adverse response to anti-depressants. These may include weight gain and raised homocysteine levels that may further compromise the health status of MDD patients and may partly explain the link with cardiovascular disease. The objective of the study was to identify genetic risk factors interacting with environmental factors implicated in MDD that may be of relevance to the South African population. Polymorphisms in the MTHFR (677 C>T, rs1801133 and 1298 A>C, rs1801131), COMT (472G>A, rs4680), CYP2D6 (6937G>A, rs3892097), ASMT (24436 G>A, rs4446909) and SLC6A4 (43 bp ins/del, rs4795541) genes were genotyped in 86 MDD patients and 97 population-matched controls. The specific aims were 1) to analytically validate high throughput real-time polymerase chain reaction (RT-PCR) genotyping assays for the selected SNPs against direct sequencing as the gold standard for 2) possible integration into a pathology-supported genetic testing strategy aimed at improved clinical management of MDD. A total of 183 unrelated Caucasians participated in the study, including 69 females and 17 males with MDD and 57 female and 40 male controls without a personal and family medical history of overlapping stress/anxiety and depressive disorders. All study participants were genotyped for the six selected SNPs considered clinically useful based on international data. The allelic distribution of the SNPs, single or combined into a genotype risk score after counting their minor alleles, did not differ between MDD patients and controls. Homocysteine levels were determined and correlated with body mass index (BMI) and other variables known to influence these phenotypes. The folate score assessed with use of the study questionnaire was significantly lower in the patient group compared with controls (p=0.003) and correlated significantly with BMI, particularly in females (p=0.009). BMI was on average 8% higher in the MDD patients compared with controls (p=0.015) after adjustment for age and sex. The MTHFR rs1801133 677 T-allele was associated with a 14% increase in BMI in MDD patients but not controls (p=0.032), which in turn was associated with significantly increased homocysteine levels (p<0.05). The aims of the study were successfully achieved. Identification of the MTHFR rs1801133 677 T-allele reinforces the importance of adequate folate intake in the diet due to increased risk of obesity and depression found to be associated with low dietary intake. Evidence of shared genetic vulnerability for many chronic diseases and drug response mediated by the MTHFR 677 T-allele support the clinical relevance of this low-penetrance mutation.
AFRIKAANSE OPSOMMING: Major depressie (MD) is ‘n aftakelende siektetoestand wat tot selfdood kan lei. Onkunde oor die siekte se onderliggende biologiese meganismes lei dikwels tot ‘n lukrake terapeutiese benadering. Dit is ‘n onbevredigende situasie aangesien indiwidue verskillend reageer op die middels wat voorgeskryf word. Navorsing toon dat slegs ongeveer die helfte van MD pasiënte toepaslike behandeling kry, terwyl anti-depressante ‘n nadelige uitwerking het op baie pasiënte. Dit sluit massatoename en verhoogde homosisteïenvlakke in wat MD pasiënte se gesondheid bykomend nadelig kan beïnvloed en die verband met kardiovaskulêre siekte gedeeltelik kan verklaar. Hierdie studie poog om MD verwante genetiese risikofaktore en omgewingsfaktore wat mekaar beïnvloed en moontlik op die Suid Afrikaanse bevolking betrekking het, te identifiseer. Polimorfismes in die MTHFR (677 C>T, rs1801133 en 1298 A>C, rs1801131), COMT (472G>A, rs4680), CYP2D6 (6937G>A, rs3892097), ASMT (24436 G>A, rs4446909) en SLC6A4 (43 bp ins/del, rs4795541) gene is geanaliseer in 86 MD pasiënte en 97 kontroles geselekteer van dieselfde populasie. Die spesifieke doelwitte was om 1) hoë deurset direkte polimerase kettingreaksie (RT-PCR) genotiperingstoetse vir die 6 gekose polimorfismes met direkte volgordebepaling as maatstaf analities te valideer vir 2) moontlike insluiting in ‘n patologie-ondersteunde genetiese toetsstrategie met die oog op beter kliniese hantering van MD. Altesaam 183 Kaukasiërs het aan die studie deelgeneem. Die MD pasiënte het uit 69 vroue en 17 mans bestaan. Die kontroles (57 vroue en 40 mans) het geen mediese geskiedenis (persoonlik of familie) van oorvleuelende stress/angstigheid of depressie gehad nie. Gebaseer op internasionale data, is al die deelnemers vir die 6 gekose, potensieel klinies-bruikbare polimorfismes getoets. Die alleliese verspreiding van die polimorfismes enkel of gekombineer (uitgedruk as ‘n genotipe-risiko-syfer nadat minor allele getel is), was dieselfde in MD-pasiënte en kontroles. Homosisteïenvlakke is bepaal en gekorreleer met die liggaamsmassa-indeks (BMI) en ander veranderlikes wat bekend is vir hulle invloed op hierdie fenotipes. In teenstelling met die kontroles, was die folaat telling, soos bepaal met die studievraelys, betekenisvol laer in die pasiënte (p=0.003). Die korrelasie met die liggaamsmassa-indeks, spesifiek by vroue, was ook betekenisvol (p=0.009). Na aanpassings vir ouderdom en geslag, is gevind dat die liggaamsmassa-indeks gemiddeld 8% hoër was in die die MD pasiënte teenoor die kontroles. By MD-pasiënte, maar nie by die kontroles nie, is die MTHFR rs1801133 677 T-alleel geassosieer met ‘n 14% toename in liggaamsmassa-indeks (p=0.032), wat ook geassosieer was met betekenisvolle verhoogde homosisteïenvlakke (p<0.05). Die doelwitte van die studie is bereik. Identifisering van die MTHFR rs1801133 677 T-alleel beklemtoon hoe belangrik dit is om voldoende folaat in te neem, veral omdat ‘n verhoogde risiko vir vetsug en depressie met ‘n lae folaatinname in die diet geassosieer word. Die kliniese belang van die MTHFR 677 T-alleel word beklemtoon deur toenemende bewyse wat daarop dui dat gedeelde genetiese vatbaarheid vir ‘n verskeidenheid van kroniese siektes asook middelrespons aan bemiddeling deur hierdie lae penetrasie mutasie toegeskryf kan word.
Winetech
Technology for Human Resources and Industry Program (THRIP).
Zhang, Hanshuo. "Large-scale identification of functional genes regulating cancer cell migration and metastasis using the self-assembled cell microarray." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/49066.
Full textWautier, Jacqueline A. "L'humanité à l'épreuve de la génétique et des technosciences." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211029.
Full textPar ailleurs, nous définissons l’individu d’une indéfinition :où l’homme est point de convergence (entre divers états, plans et déterminants) et force d’émergence (hors ses donnés) - équilibre en construction incessante et incessible. Où sa spécificité tient à l’occupation corporelle et pensée d’un espace et d’un temps :équilibre en soutenance entre stase et métabolisme, non-soi et soi, subordinations et libérations, centralisations identitaires et extériorisations identifiantes. Par suite, toute intervention pesant en déséquilibre sur ces articulations devrait être évitée – en principe. En principe car, du fait de la multiplicité et de la diversité des intervenants, du fait même de leur liberté et des incertitudes plurielles, il y aura toujours pression ou déséquilibre. Néanmoins, il importe de mesurer l’acte aux conditions de la liberté et de l’humanité :conscience, autonomie, libre disposition de soi, sensibilité, émotivité, souci, malléabilité principielle (contre une assignation à demeure spécielle ou existentielle) et réappropriation essentielle (contre un déterminisme global – une appropriation par tiers). Et il convient de préserver le lien du corps et de l’esprit :où l’esprit transcende le corps qui le forme et l’informe – selon une mise à distance au sein d’une unité (et d’une unicité).
Or, nous constatons que l’humanitude, prise en charge par les techniques qu’elle produit, édifie un domaine existentiel caractérisé par une biographie de l’arrachement ou du désinvestissement. Et que l’homme, être de l’entre-deux défini par la négation de tout Etat advenu, produit un processus technique propre à l’extraire de cet «entre-deux». Déjà, l’individu libère ses tendances dispersives et ses tendances confusionnelles :mise à distance de l’entité corporelle (en sa force référentielle ou définitoire), identité décisionnelle et puissance volitive plus dispersive que centralisatrice. Où donc néoténie, imparfaite assignation, distanciation et in-essentialité ouvrent à la liberté tout en autorisant l’incorporation du non-soi, l’opérativité de la volonté et l’évanescence des états de l’organisme et de la psyché (de la personnalité comme tout identitaire). Cependant, si les techniques font exploser ces équilibres, reste la dissipation :où le «soi serait amené à se reconnaître comme pure et simple concept construit. Dans ce contexte, tout s’abandonne aux modifications. Et l’homme de jouer avec le donné et le donné en lui - donné qui est lui mais se décompose dorénavant en fonds «sacral» de puissances, en substrats géniques, mnésiques et morphologiques modelables et en constituants interchangeables. Semblable attitude recouvre une fuite hors de la condition humaine :tantôt vers «autre chose», tantôt vers un alignement démissionnaire sur un Décideur Transcendant. Et pour la première fois aussi globalement et intensément, instinct et volonté de survivre se soumettent à leur propre négation :pour qu’il subsiste «quelque chose plutôt que rien» dans le futur lointain, l’espèce conspire à sa propre fin. Pour la première fois (première fois aussi proche d’une réalisation), l’individu aspire à une dispersion de conscience, à une évanescence personnale et à une fin de l’Histoire sous couvert d’une histoire sans fin et d’un devenir incessant – gardant du devenir la seule processualité mécanique. Le danger est alors considérable car l’homme sort de l’animalité dans le champ où s’entrechoquent libre arbitre et déterminisme, références identitaires et décentrages, appartenances et abstractions. Car cet animal-là exprime sa spécificité à l’extérieur de l’enceinte biologique mais à partir d’une densité individuale :dans l’élaboration sociale et culturelle. Dès lors, quand l’existence précède l’essence et face aux possibles technoscientifiques, il importe de préserver l’homme d’une existenciation illusoire et d’une personnalisation évanescente. Et de pondérer la totalité individuale de ses dimensions temporelles :où l’individu est un être perpétuellement devenant ;où l’existence crée, investit et signifie une durée ;où l’identité est continuité d’unicité en devenir ;où l’humanité est construction d’Histoire et invention de sens. Cela oblige l’individu à se soutenir eu égard à des doubles nœuds référentiels :anthropique et autobiographique, culturel et familial, spirituel ou décisionnel et charnel ou factuel, symbolique et opératoire, autoréférentiel et relationnel. Mais aussi, en matière éthique, entre principe et casuistique, idéal et exception, collectif et individuel.
Doubles nœuds contestés par les techniques. Aussi, face à l’opérativité croissante de celles-ci, nous nous interrogeons sur ce qu’il pourrait advenir de la condition humaine et des conditions de possibilité de l’homme - considéré ici comme individu (spécimen défini en ses spécificités) au milieu du monde, conscience (sensible et émotionnelle) en situation d’interrelation, et subjectivité (volitive) face à ses semblables.
Doctorat en philosophie et lettres, Orientation bioéthique
info:eu-repo/semantics/nonPublished
Guedeney, Antoine. "Le comportement de retrait relationnel du jeune enfant : du concept à l'outil de dépistage : résultats et perspectives de recherche." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB203.
Full textThis work deals with social withdrawal behavior in infants, its measure and its conceptual validity, its predictive value on early development within its several dimensions. This is the first synthesis on the history of the concept of withdrawal in infant, of its links with animal models, with the still face experimental paradigm, as well as with the repair process and with interactional dys- syssynchrony as a major process in early psychopathology. Social withdrawal behavior has its roots in physiology, as privileged way used by the infant to regulate the input within the parent infant interaction, within a micro temporal scale. On a longer temporal and more clinical scale, withdrawal behavior appears as a major defense maneuver when the baby is faced with major violations of his her expectations within the relationship. It is therefore observed in a privileged way in maternal post-natal depression, but also in all circumstances which hamper parental capacities, as conjugal violence and conflict may do for instance. Social withdrawal behavior may be as well linked with difficulties in processing sensorial input in the child, or difficulties in social communication and synchrony, or be due to an intense and sustained pain, or be linked with some genetic disorder or with some association of these factors. This work retraces the construction of a scale to asses social withdrawal behavior in infants, since no such tool existed at the time, although social withdrawal behavior appears to be an important alarm signal, showing the inability of the child to play the relational game as his her developmental level allow him or her to do, be it for causes related to himself or herself, for relational causes of because of both. This work opens on a history of the development of child psychiatry and of the coming of ages of infant development. Social withdrawal behavior took a large place at the onset of this history, with the description of autism by Kanner and anaclitic depression by Spitz. Then a history of the concept of social relational withdrawal, and of the construction of the alarm distress scale (8 item) the of the short version (5 item m-ADBB), then the studies on long term effects of social withdrawal on development. We then review the application of the scale on early diagnosis of autism, on the several factor analysis with several samples, and of the several epigenetic and genetic pathways of the social withdrawal behavior. This work reviews the results of several controlled studies with the ADBB, particularly those from the perinatal French EDEN cohort. Social withdrawal behavior appears as the result of a gene interaction, based on the genetic c susceptibility for social withdrawal behavior, possibly liked with the 5-HTPPR allele system. On a cognitive level, the issue is raised of social withdrawal behavior as a choice of a risk taking position in an uncertain situation. Follow up studies show the impact of the social withdrawal behavior on several dimensions of early development, i.e. language, early development of intersubjectivity or emotional regulation
Cox, Susan M. ""It’s not a secret but-- " : predictive testing and patterns of communication about genetic information in families at risk for Huntington Disease." Thesis, 1999. http://hdl.handle.net/2429/9955.
Full textHuerter, Mary Elise. "Prenatal Screening: Quality Control and the Genetics Gateway." Thesis, 2007. http://hdl.handle.net/1805/1131.
Full textDepartment of Philosophy, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Jason T. Eberl, Peter H. Schwartz, William H. Schneider. Includes vitae. Includes bibliographical references (leaves 71-81).
Bergh, Lorinda Brink. "Evaluation of a treatment programme for incarcerated rapists." Thesis, 2003. http://hdl.handle.net/2263/28300.
Full textThesis (PhD (Psychology))--University of Pretoria, 2006.
Psychology
unrestricted
"Genetics and genomics of allergic diseases." Thesis, 2011. http://library.cuhk.edu.hk/record=b6075403.
Full textThesis (Ph.D.)--Chinese University of Hong Kong, 2011.
Includes bibliographical references (leaves lxxiv-xciv).
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Abstract also in Chinese; appendixes I-III in Chinese.
Davis, Kim Suzanne 1979. "The influence of genetic disorders on parenting stress and family environment." Thesis, 2007. http://hdl.handle.net/2152/3224.
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Sow, Mounirou El-Hassimi. "Genetic diversity of Oryza species in Niger ; screening and breeding for resistance to rice yellow mottle virus (RYMV)." Thesis, 2012. http://hdl.handle.net/10413/8520.
Full textThesis (Ph.D.)-University of KwaZulu-Natal, Pietermaritzburg, 2012.
Meehan, Mitchell Elwin. "A comparison of techniques for screening for resistance to the chinch bug, Blissus leucopterus leucopterus (Say), in sorghum." 1985. http://hdl.handle.net/2097/27497.
Full textKabahuma, Rosemary I. "Genetic aspects of hearing loss in the Limpopo Province of South Africa." Thesis, 2010. http://hdl.handle.net/10539/8566.
Full textMotseotsile, Baitlhatswi Gaolatlhe. "Reasons for post-conception human immunodeficiency virus (HIV) testing among pregnant women in Gaborone, Botswana." Thesis, 2014. http://hdl.handle.net/10210/12314.
Full textFree voluntary counselling and testing (VeT) for Human Immunodeficiency Virus (HIV) by the international community and many African states is the entry point into HIV and Acquired Immunodeficiency Syndrome (AIDS) prevention, care, treatment and support. It is therefore worrisome that despite the Botswana government' multiple HIV preventative strategies, of the 56% Batswana who tested for HIV in 2008, only 34% know their status (National AIDS Coordinating Agency, Central Statistics Office & Ministry of Health, 2009:4). Among those who were tested, women outnumbered men, but even these women only had their HIV-status tested when they were already pregnant or when one of their children was suspected to have contracted AIDS, an observation that Hamblin and Reid (1991:4) has made years ago. Ethical standards were followed to conduct a study, the purpose of which was to explore and describe the reasons why women in Gaborone only volunteered to go for vcr of HIV when they were already pregnant, instead ofdoing so before they conceived. An exploratory, descriptive, qualitative and contextual design was used. Participants who met the sampling criteria were interviewed and data was audio-taped before transcription and analysis. An independent coder was involved to confirm the themes and sub-themes before relevant literature was searched. Strategies of trustworthiness were adhered to in the study (Lincoln & Guba, 1985:289-331). Findings revealed that the most significant reason for participants not testing for HIV prior to pregnancy was fear of consequences of an HIV-positive result, such as stigma and discrimination against them by their partners, families and communities should they test HIV-positive, Another reason was the socio-cultural beliefs, norms and values expressed in different forms. However, once they fell pregnant, they had themselves tested because their fear of losing their babies to HIV overruled their fear ofbeing ostracised by anybody else. Based on the findings, guidelines were formulated to assist midwives and HIV and AIDS counsellors to facilitate uptake of vcr of HIV prior to pregnancy among childbearing women and men from as young as +-15 years. Conclusions were drawn and recommendations made concerning midwifery practice, education and possible further research on this topic on a larger scale.
Watson, Susan Brooks. "Clinical utility and incremental validity of brief screening for traumatic event exposure in female university health service patients." Thesis, 2005. http://hdl.handle.net/10125/11895.
Full textThesis (Ph. D.)--University of Hawaii at Manoa, 2005.
Evidence suggests that routine screening of primary care patients for exposure to traumatic life events, and particularly assaultive trauma, may yield both clinical and cost benefits for healthcare systems (e.g., Green, Epstein, Krupnick, & Rowland, 1997; Lecrubier, 2004). However, although advocated by authorities, such screening has yet to be widely adopted. A sample of female university healthcare patients (N = 339) was assessed for exposure to trauma in order to examine several unaddressed issues that may diminish the clinical utility of screening for trauma in primary care patients. First, because the length of the traditional trauma history assessment makes it less acceptable for use in time-pressured primary care settings, the discriminative validity of a brief, self-administered screening question about exposure to trauma, the Structured Clinical Interview for DSM-IV (SCID) posttraumatic stress disorder (PTSD) module's screening question (First, Spitzer, Williams & Gibbon, 1997) was compared to a longer, inventory method of assessment, the Traumatic Life Events Questionnaire (TLEQ, Kubany et al., 2000). Second, because it is unclear whether patients who have experienced assaultive trauma will disclose these experiences when asked in a primary care setting, the relative predictive efficacy of informing respondents that their responses would, or would not be, disclosed to health center personnel was evaluated. Two versions of the brief screening question were assessed across two instructional sets regarding disclosure, to determine each condition's relative classification accuracy for identifying respondents who reported experiences of sexual or physical assault, and/or symptoms of PTSD. The brief screen identified more than three-quarters of the survivors of traumatic assault; and more importantly, identified almost all of the women who reported significant PTSD symptomatology: the inventory method identified only 2 additional women of the 47 who met criteria for PTSD. Although survivors of sexual assault were significantly less likely to disclose their history to their provider, no differences were found for those assault survivors who also reported symptoms of PTSD. Results suggest that a brief screening question about traumatic life events may be an acceptable option in settings where more time-consuming assessment procedures are not practical.
Includes bibliographical references (leaves 83-98).
Electronic reproduction.
Also available by subscription via World Wide Web
x, 98 leaves, bound 29 cm
Fernihough, Melissa. "Congenital facial deformity : experiences of mothers of twins." Diss., 2011. http://hdl.handle.net/10500/4935.
Full textPsychology
M.A. (Clinical Psychology)
Ernst, Jody Lynn. "Genetic and environmental influences of maternal psychosocial and antisocial tendencies on the development, stability, and continuity of problem behaviors in adoptees from the Texas Adoption Project: a life course investigation of risk, resilience, and vulnerability." Thesis, 2006. http://hdl.handle.net/2152/3446.
Full textModula, Mantji Juliah. "Nurses' understanding and implementation of mental health screening among HIV infected in Limpopo." Diss., 2016. http://hdl.handle.net/10500/21191.
Full textHealth Studies
M.A. (Nursing Science)
Matson, Liana M. "Investigating reactivity to incentive downshift as a correlated response to selection for high alcohol preference and a determinant of rash action and alcohol consumption." Thesis, 2014. http://hdl.handle.net/1805/5964.
Full textLosing a job or a significant other are examples of incentive shifts that result in negative emotional reactions. The occurrence of negative life events is associated with increased drinking, and alleviation of negative emotions has been cited as a drinking motive for individuals with problematic drinking patterns (Keyes et al., 2011; Adams et al., 2012). Further, there is evidence that certain genotypes drink alcohol in response to stressful negative life events (Blomeyer et al., 2008; Covault et al., 2007). It is possible that shared genetic factors contribute to both alcohol drinking and emotional reactivity, but there is a critical need for this relationship to be understood. The first aim of this proposal will use an incentive downshift paradigm to address whether emotional reactivity is elevated in mice predisposed to drink alcohol. The second aim of this proposal will address if reactivity to an incentive shift can result in rash action using a differential reinforcement of low rates of responding task, and whether this response is also associated with a predisposition for high drinking. The third aim of this proposal will investigate if experimenter administered ethanol reduces contrast effects, and if an incentive shift increases ethanol consumption in a high drinking line. The overall goal of this proposal is to investigate whether reactivity to incentive shift is an important mechanism underlying alcohol drinking in these mice, and the role an incentive shift may play in producing rash action and influencing ethanol consumption.