Relevant bibliographies by topics / Genetic screening – Psychological aspects

Academic literature on the topic 'Genetic screening – Psychological aspects'

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Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Genetic screening – Psychological aspects"

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Green, J. M., and M. P. M. Richards. "Psychological aspects of fetal screening and the new genetics." Journal of Reproductive and Infant Psychology 11, no. 1 (January 1993): 1–2. http://dx.doi.org/10.1080/02646839308403188.

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Ramalho, Antonio Sérgio, and Roberto Benedito de Paiva e. Silva. "Community Genetics: a new discipline and its application in Brazil." Cadernos de Saúde Pública 16, no. 1 (January 2000): 261–63. http://dx.doi.org/10.1590/s0102-311x2000000100029.

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Community genetics is a new discipline which aims to provide genetic services to the community as a whole. As a science, community genetics encompasses all research needed to develop and evaluate its application. There is no question that the development of community genetics is necessary in Brazil. The implementation of such programs in our country, especially for hemoglobinopathies, has been recommended by the World Health Organization and other international organizations. Apart from the need for and appeal of community genetics programs, some aspects require serious review. This article discusses various cultural, social, psychological, and economic factors that can make genetic screening an invasion of individual privacy
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Anderson, Gwen. "Nondirectiveness in Prenatal Genetics: patients read between the lines." Nursing Ethics 6, no. 2 (March 1999): 126–36. http://dx.doi.org/10.1177/096973309900600205.

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For decades questionnaires have been used to measure the cognitive and psychological effects of prenatal genetic testing, but little is known about why some women undergo testing and others decline. Research indicates that many factors influence decision making, including values and beliefs. What is often denied rather than recognized is that the professional and personal values and beliefs held by the health care provider influence the patient’s decision. It is assumed that, if genetic services are delivered in a nondirective manner, patients will not be affected by the provider’s personal and professional standpoint. The qualitative research data reported here challenge this assumption. Getting to know patients’ moral understanding and patterns of ethical reasoning by listening to their personal stories is recommended as a better way for nurses to help patients to make informed and autonomous decisions about prenatal genetic screening or diagnostic tests.
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Allen, Clarissa, Karine Sénécal, and Denise Avard. "Defining the Scope of Public Engagement: Examining the “Right Not to Know” in Public Health Genomics." Journal of Law, Medicine & Ethics 42, no. 1 (2014): 11–18. http://dx.doi.org/10.1111/jlme.12114.

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While the realm of bioethics has traditionally focused on the rights of the individual and held autonomy as a defining principle, public health ethics has at its core a commitment to the promotion of the common good. While these two domains may at times conflict, concepts arising in one may also be informative for concepts arising in the other. One example of this is the concept of a “right not to know.” Recent debate suggests that just as there is a “right to know” information about one's genetic status, there is a parallel “right not to know” when it comes to genetic information that if communicated, could be detrimental to an individual's social or psychological well-being. As new genetic technologies continue to change the nature of genetic testing and screening, it is crucial that normative frameworks to guide and assess genetic public health initiatives be developed. In this context, the question of whether a “right not to know” may also be said to exist for populations on a public health level merits attention.
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Negredo, Eugenia, David Back, José-Ramón Blanco, Julià Blanco, Kristine M. Erlandson, Maite Garolera, Giovanni Guaraldi, et al. "Aging in HIV-Infected Subjects: A New Scenario and a New View." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/5897298.

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The prevalence of HIV-infected people aged 50 years or older is increasing rapidly; the proportion will increase from 28% to 73% in 2030. In addition, HIV-infected individuals may be more vulnerable to age-related condition. There is growing evidence that the prevalence of comorbidities and other age-related conditions (geriatric syndromes, functional or neurocognitive/mental problems, polypharmacy, and social difficulties) is higher in the HIV-infected population than in their uninfected counterparts. However, despite the potential impact of this situation on health care, little information exists about the optimal clinical management of older HIV-infected people. Here we examine the age-related conditions in older HIV-infected persons and address clinical management according to author expertise and published literature. Our aim is to advance the debate about the most appropriate management of this population, including less well-studied aspects, such as frequency of screening for psychological/mental and social and functional capabilities.
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Costan, Laura, Matthew J. Devine, Maud van Dinther, Louise Hendrickx, Job Meijer, Nynke van Uffelen, and Eline Zenner. "Down to Counsel: Towards A Transdisciplinary Toolbox for Non-directive Counseling in Prenatal Screening for Down Syndrome." Transdisciplinary Insights 2, no. 1 (December 15, 2018): 38–77. http://dx.doi.org/10.11116/tdi2018.2.2.

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Abstract Since the introduction of non-invasive prenatal testing (NIPT) in Belgium in 2013, expectant parents have had access to a new efficient and reliable test for genetic abnormalities, including trisomy 13, 18 and 21. In 2017, the Belgian government decided to cover over 95% of the cost for all women who choose to take this test. In this context, a diagnosis of trisomy 21 (Down syndrome) presents an especially challenging decision for parents: it is impossible to tell the severity of impairment prenatally, and although several medical risks are involved in the condition, many individuals with Down syndrome live a long, happy, and relatively independent life (Shakespeare, 1998; Scott et. al., 2014). Expectant parents face a very difficult situation: how to decide whether or not to terminate a pregnancy? It appears that termination is becoming the routinized outcome of the clinical encounter during which a diagnosis is delivered.The intricacy of the matter, and the fact that many actors are involved, lead to the necessity of a transdisciplinary methodology when scrutinizing the future of prenatal counseling. However, medical professionals tend to approach Down syndrome from an exclusively medical perspective (Skirton and Barr, 2010), leaving aside the economic, social and psychological dimensions of living with Down syndrome. This may result in unbalanced information; some (perhaps precipitously) refer to this phenomenon as ‘nudging practices’ (Hippman et. al., 2012; Reid et. al., 2009). In order to address this imbalance, we adopt a stakeholder approach in this project: we consulted <target target-type="page-num" id="p-39"/>experts with diverse backgrounds and fields of expertise. Through this transdisciplinary approach, we hope to bring about a more transdisciplinary perspective directly within the offices of gynecologists and GPs. More specifically, we aim to find ways to provide GPs and gynecologists with direct access to information about the aforementioned dimensions of Down syndrome.The next step is to define a strategy to achieve this goal. Given the fact that medical professionals often lack both time and easy access to concise information about Down syndrome to present a nuanced perspective (Ahmed et. al., 2007), but are still the first in the prenatal screening process, the output of this project is the idea of an online tool in a succinct Q&A format. The goal of such a website would be to provide up-to-date, easily accessible and balanced information for general practitioners and gynecologists on multiple aspects of Down syndrome. This way, in anticipation of and directing explicitly towards further counseling by a multidisciplinary team, physicians can provide expectant parents with a more balanced, transdisciplinary view of Down syndrome, thereby enhancing their capability to make informed, autonomous and hence sustainable decisions about their pregnancies.
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Modell, Bernadette. "Ethical Aspects of Genetic Screening." Annals of Medicine 24, no. 6 (January 1992): 549–55. http://dx.doi.org/10.3109/07853899209167009.

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Lerman, Caryn, Robert T. Croyle, Kenneth P. Tercyak, and Heidi Hamann. "Genetic testing: Psychological aspects and implications." Journal of Consulting and Clinical Psychology 70, no. 3 (2002): 784–97. http://dx.doi.org/10.1037/0022-006x.70.3.784.

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Szarewski, Anne. "Social and psychological aspects of cervical screening." Expert Review of Obstetrics & Gynecology 6, no. 1 (January 2011): 37–44. http://dx.doi.org/10.1586/eog.10.69.

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Philip, T., R. Ladenstein, P. Kogner, L. Perrier, and C. Bergeron. "Screening for neuroblastoma: ethical and psychological aspects." Medical and Pediatric Oncology 31, no. 5 (November 1998): 421–25. http://dx.doi.org/10.1002/(sici)1096-911x(199811)31:5<421::aid-mpo6>3.0.co;2-j.

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Dissertations / Theses on the topic "Genetic screening – Psychological aspects"

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Lesniak, Karen. "Psychological and Sociodemographic Predictors of Psychological Distress in BRCA1 and BRCA2 Genetic Testing Participants within a Community Based Genetic Screening Program." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2565/.

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Mutations in BRCA1 and BRCA2, the first two breast cancer susceptibility genes identified, carry as much as an 85% lifetime risk of developing breast, ovarian or other cancers. Genetic testing for mutations in these two genes has recently become commercially available. There have been varying amounts of psychological distress noted among women with a family history of breast cancer. Distress has been observed to impact psychological functioning, activities of daily living, and the practice of breast cancer surveillance behaviors. Within the genetic screening process, psychological distress has been shown to impact the decision to undergo genetic screening, the comprehension and retention of risk assessment information, as well as affecting the subject following the receipt of the genetic test results. Little work has been done to examine predictors of distress within at risk subjects. This study examines psychological distress among 52 community women presenting for BRCA1 and BRCA2 genetic mutation testing. Predictors of distress included family cancer history, education, age, Ashkenazi ethnicity, and Internality and Powerful Others Health Locus of Control. Vulnerable sub-groups of patients include younger women, women with higher levels of education and women of Ashkenazi ethnicity.
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Keenan, Lisa A. "Family Environment, Social Support, and Psychological Distress of Women Seeking BRCA1 and BRCA2 Genetic Mutation Testing." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3240/.

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Shared characteristics and predictors of psychological distress are beginning to be identified in research on women seeking genetic testing for BRCA1 and BRCA2 gene mutations. This study further explored patterns of psychological distress for 51 community women waiting to receive such genetic test results. There was no significant relationship between psychological distress and family cancer history, personal cancer history, social support networks, and family environment. Women in this sample tended to rely more on females and relatives for support than males and friends. Social support satisfaction was not related to gender or number of relatives providing support. Thirty-four of the 36 women classified on the family environment type were from Personal Growth-Oriented families. Comparisons with normal and distressed family means revealed increased cohesion and expressiveness with decreased conflict, indicative of supportive family environments. Limitations and implications are discussed.
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Elliott, Diana. "The impact of genetic counselling for familial breast cancer on women's psychological distress, risk perception and understanding of BRCA testing." University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0190.

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[Truncated abstract] Background: A review of the literature indicated there was a need for more long-term randomised controlled studies on the effects of BRCA counselling/testing on high risk women, including improved strategies for risk communication. Reviews have also shown women are confused about the significance of inconclusive or non informative results with a need for more research in this area. Aims: The general aim of this study was to evaluate the impact of breast cancer genetic counselling on psychological distress levels, perception of risk, genetic knowledge and understanding of BRCA testing/test results in a cohort of 207 women from high risk breast cancer families who were referred for genetic counselling in Perth during the period 1997 to 2001. Short- and long-term impact of BRCA genetic counselling/testing was determined in women with and without cancer in a randomised controlled trial as part of which women were randomised to either receive immediate versus delayed genetic counselling. This included family communication patterns before BRCA testing, anticipated outcomes of testing on oneself and family including intentions for result disclosure. Comprehension of index and predictive BRCA testing with possible results was assessed both in the short- and the long-term and understanding of individual or family BRCA test results was evaluated at long-term. The effect of genetic counselling on breast cancer risk perception in unaffected women was evaluated. This study considered a theoretical framework of educational learning theories to provide a basis for risk communication with possible relevance for future research. ... Only 25% of the original study population (52/207) reported BRCA results and women's understanding of results is concerning. Key findings were: 1. The majority of affected women received an inconclusive result. 2. Out of twelve unaffected women who reported results, seven were inconclusive which are not congruent with predictive testing. This implies that these women did not understand their test result. 3. A minority of untested relatives did not know whether a family mutation had or had not been found in their tested family member or what their actual test result was. This implies either a lack of disclosure or that woman did not understand the rationale for and significance of testing for a family mutation. 4. Three relatives did not understand a positive result was a mutation. Conclusion: The implication of this research for breast cancer counselling and testing services is that women who wait for counselling are no worse off in terms of short- or long-term general psychological distress than women who receive the intervention early. There is a suggestion that unaffected women without the disease found counselling more advantageous than affected women. The meaning of BRCA results as reported by women is concerning particularly women's understanding of negative and inconclusive results and further research is needed in this area. Too much information presented at counselling may affect women's comprehension of risk, BRCA testing and future test results and further research is required to evaluate the effects of information overload.
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Steggles, Naomi. "Psychological aspects of genetic testing for cancer." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271020.

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Marerro, Magaly V. (Magaly Victoria). "Primary Care Screening for Psychological Factors." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331793/.

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The Behavioral Medicine Questionnare (BMQ) is a 44- item instrument administered via a computer CRT display or pencil and paper. The BMQ was designed to help primary care physicians treating spinal disorders to screen for emotional factors which warrant further psychological evaluation. The test is composed of three scales: Anxiety, Depression, and Somatization. Concurrent validity for each scale was determined through comparisons with subject (n = 133) scores on clinician judgement ratings, pain drawings, and the MMPI. The psychometric properties of the test were supported through statistical analysis. Significant correlations were found between the BMQ, MMPI, and clinician ratings, with the latter showing relationships of lesser strength. The only significant correlation to subject generated pain drawings was to the BMQ depression scale. Analysis indicated the need for seperate norms for males and females. Further research is needed to facilitate measurement and interpretation of the BMQ.
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Lau, Yvonne, and n/a. "The enthusiasm for disease screening : an ethical critique with a sociological perspective." University of Otago. Dunedin School of Medicine, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090121.085918.

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Screening is generally considered a useful strategy in the prevention of chronic diseases. The notion is that early detection through the use of certain screening tests can facilitate effective preventive measures to be undertaken which can then lead to improved prognosis from or ultimate avoidance of serious clinical diseases. The enthusiasm for screening in the United States is high and can be seen by the size of public demand for it. Rapid technological advances and knowledge expansion in the past decade have further facilitated the introduction of new tests and screening opportunities. In the mean time, the concept of screening has undergone subtle changes. Previous emphasis on clear and demonstrable population health benefits has been slowly replaced by an emphasis on individual responsibility for the surveillance of personal health risks. Disease screening is frequently advocated as part of a health promotion programme. As a clinician who has worked in breast cancer screening and who is wary of the complexities and problems associated with disease screening, my contention is that the enthusiasm for screening may not ultimately be conducive to health and well-being. This thesis represents an effort to understand the popularity and enthusiasm for disease screening, how it has come about and, why it may not be conducive to health and well-being. The thesis begins with a description of the phenomenon to be followed by a detailed examination of the scientific principles behind disease screening. It then moves on to discover how the phenomenon might have come about by first considering the evolution of biomedicine over the centuries and then its present endeavour in the form of surveillance medicine as well as the latter�s relationship with today�s market economy. Using relevant case studies that involve, for example, cancer and prenatal genetic screening, this thesis explores different concerns relating to health and well-being, including such topics as the creation of health roles, the reconfiguration of human values and interpersonal relationships as well as medicalisation. A final chapter offers an account of health and well-being and sums up why the enthusiasm for screening may not be conducive to health and well-being. The enthusiasm for screening compels people to assume health as a moral virtue. Screening is turned into a ritual that people consume to attain salvation. Since diseases may lead to death, diseases must be avoided though screening. Yet health is not just about the absence of disease. Health and well-being can only be realised by the individual within the context of the individual�s life as a whole. The institution of biomedicine has undeniable responsibility to ensure that screening will not be used to the detriment of individuals� health and well-being. Without condemning disease screening as a potentially useful tool in the prevention of disease, this thesis advocates prudence in its utilisation. People must not be compelled to attend screening through programmes of promotion (commercially related or not). Rather, autonomous decisions must be facilitated as far as possible through the provision of clear, accurate and factual information.
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Tedgård, Ulf. "Prenatal diagnosis of haemophilia psychological, social and ethical aspects /." Malmö : Dept. of Pediatrics, University Hospital of Malmö, University of Lund, 1999. http://catalog.hathitrust.org/api/volumes/oclc/57455671.html.

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馮敬業 and King-yip Fung. "Screening of recurrent BRCA gene mutations in Chinese breast and ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969720.

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Hayat, Roshanai Afsaneh. "Psychological and Behavioral Aspects of Receiving Genetic Counseling for Hereditary Cancer." Doctoral thesis, Uppsala universitet, Vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128870.

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The overall aims of this thesis were to investigate psychological and behavioral effects of receiving cancer genetic counseling for breast, ovarian and colorectal cancer and/or with a family history of these cancer types and to determine whether counselees’ informational needs were met. Study I was performed 3-7 years post-counseling. Participants (n=214) reported a relatively high level of anxiety but a low level of depression compared to cancer patients in general. However, there was no indication that the distress experienced was due to the counseling. Moderate changes in life and family relations, high level of adherence to recommended controls and satisfaction was reported. Study II was a randomized control trial (RCT) intervention study which involved 147 counselees. An increase in the level of knowledge and correct estimation of personal risk was reported in both the intervention and control groups, although this increase declined at later follow-up. Enhanced information led to significantly greater satisfaction with the given information, and the way of informing relatives. Most counselees had shared information with their at-risk relatives. Study III focused on sharing information with at-risk relatives among participants in study II and their relatives (n=81). Counselees were interviewed and answered a questionnaire, whilst their relatives only answered the questionnaire. Counselees reported positive/neutral feelings about communicating genetic information and mostly interpreted their relatives’ reactions as positive/ neutral. Also, approximately 50% of relatives reported positive/neutral reactions and were generally satisfied with the received information. Study IV was conducted in Sweden and Norway based on 235 counselees. Counselees expected counselors to be skillful and thoughtful, take them seriously and provide risk estimations and medical information. Most important issues to counselees were satisfactorily addressed by the counselors. Analyzing importance rankings resulted in five categories of needs: a need for facts, caring communication and medical information, need for understanding and support in sharing genetic information, practical care and medical/practical information. In conclusion, no adverse psychological or behavioral effect on counselees was observed. Apparently, genetic counseling is managed properly and counselors successfully address counselees’ needs. Providing extended information does not seem necessary, however, tailoring information to individual counselees needs may create a more effective counseling.
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Ng, Wai-tong, and 吳偉棠. "Early detection and screening of familial nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290720.

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Books on the topic "Genetic screening – Psychological aspects"

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Fischer, Michael W., and Markus Hengstschläger. Genetic screening. Frankfurt am Main: Peter Lang, 2009.

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Sommer, Annemarie. Birth defects and genetic screening and counseling. Washington, D.C: Veterans Administration Central Office, Dept. of Medicine and Surgery, Agent Orange Projects Office, 1985.

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Sommer, Annemarie. Birth defects and genetic screening and counseling. Washington, D.C: Veterans Administration Central Office, Dept. of Medicine and Surgery, Agent Orange Projects Office, 1985.

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Juth, Niklas. Genetic information values and rights: The morality of presymptomatic genetic testing. Göteburg: Acta Universitatis Gothoburgensis, 2005.

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Presurgical psychological screening: Understanding patients, improving outcomes. Washington, DC: American Psychological Association, 2013.

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Mara, Buchbinder, ed. Saving babies?: The consequences of newborn genetic screening. Chicago: The University of Chicago Press, 2013.

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What we have: A memoir. New York: Gotham Books, 2010.

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1942-, Taylor Robert L., ed. Distinguishing psychological from organic disorders: Screening for psychological masquerade. New York: Springer Pub. Co., 1990.

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Dierickx, Kris. Genetisch gezond?: Ethische en sociale aspecten van genetische tests en screenings. Antwerpen: Intersentia, 1999.

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Canada. Privacy Commissioner of Canada. Genetic testing and privacy. Ottawa, Ont: Privacy Commissioner of Canada, 1992.

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Book chapters on the topic "Genetic screening – Psychological aspects"

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Esplen, M. J. "Psychological Aspects." In Genetic Testing, 53–78. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/0471748897.ch3.

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Ellman, Ruth. "Psychological Aspects of Cancer Screening." In Focus on Cancer, 159–74. London: Springer London, 1996. http://dx.doi.org/10.1007/978-1-4471-3044-4_9.

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Cohen, Miri. "Cancer Fatalism: Attitudes Toward Screening and Care." In Psychological Aspects of Cancer, 83–99. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-4866-2_6.

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Clarke, Angus. "Population aspects of genetic counselling and genetic screening." In Harper's Practical Genetic Counselling, 439–56. Eighth edition | Boca Raton : CRC Press, [2020] | Preceded by Practical genetic counselling / Peter S. Harper. 7th ed. 2010.: CRC Press, 2019. http://dx.doi.org/10.1201/9780367371944-34.

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Aspinwall, Lisa G., Jennifer M. Taber, Wendy Kohlmann, and Sancy A. Leachman. "Psychological Aspects of Hereditary Cancer Risk Counseling and Genetic Testing." In Psychological Aspects of Cancer, 31–64. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-4866-2_3.

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Nuernberg, N. J., C. A. Bissani, T. A. Campbell, and C. D. Foy. "Screening pasture plants for aluminum tolerance." In Genetic Aspects of Plant Mineral Nutrition, 345–53. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-2053-8_52.

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Andersen, T. M., E. Polle, and C. F. Konzak. "Screening spring wheat for drought tolerance." In Genetic Aspects of Plant Mineral Nutrition, 79–87. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3581-5_7.

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Neue, H. U., R. S. Lantin, M. T. C. Cayton, and N. U. Autor. "Screening of rices for adverse soil tolerance." In Genetic Aspects of Plant Mineral Nutrition, 523–31. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-2053-8_72.

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Crotti, Nadia, and Valentina Broglia. "Psychological Aspects of High Risk of Breast Cancer." In Breast MRI for High-risk Screening, 293–307. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41207-4_19.

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Yaghmaie, Marjan, Mohammad Ahmadvand, Ali-akbar Nejati Safa, and Hossein Pashaiefar. "Genetic, Hematologic and Psychological Aspects of Leukemia." In Cancer Genetics and Psychotherapy, 667–755. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64550-6_14.

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Conference papers on the topic "Genetic screening – Psychological aspects"

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Ostroverkhova, N. V. "DARK FOREST BEE APIS MELLIFERA MELLIFERA L. IN SIBERIA: CURRENT STATE AND WAYS OF POPULATION CONSERVATION." In V International Scientific Conference CONCEPTUAL AND APPLIED ASPECTS OF INVERTEBRATE SCIENTIFIC RESEARCH AND BIOLOGICAL EDUCATION. Tomsk State University Press, 2020. http://dx.doi.org/10.17223/978-5-94621-931-0-2020-56.

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Screening studies of the honey bee in Siberia made it possible to identify the dark forest bee Apis mellifera mellifera populations in the Tomsk region, Krasnoyarsk and Altai territories, and the Altai Republic. A comparative analysis of the genetic diversity of the dark forest bee populations of Siberia, the Urals and Europe, carried out according to the data of the molecular genetic study of the mitochondrial and nuclear genomes, suggests the existence of the Siberian ecotype of the Middle Russian breed. The studied bee colonies are characterized by a high adaptive potential (high degree of "acclimatization") and good economically significant indicators. To preserve the gene pool of the Middle Russian breed of Siberian populations, monitoring studies, ecological and genetic analysis of bee colonies as well as selection and breeding work in the Tomsk bee farm are carried out.
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Liang, Yun, Keith M. Stantz, Ganapathy Krishnamurthi, Laigao Chen, and Gary D. Hutchins. "Investigation of Contrast-Enhanced In-Vivo Animal Imaging With Micro-CT." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33053.

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Rapid progress in molecular biology, much sparked by the human Genome Project, is opening a new era in medicine and biology. The development of in-vivo micro-imaging technology for small animals (mice and rats) has generated unprecedented opportunities for studying the structural and physiologic properties exhibited by different genes in a cost-effective and low-risk means. This knowledge, in turn, will help guide the study in human genetic system. Micro-computed tomograph (microCT) with resolution on the scale of micrometer is a new technique for obtaining the 3D images of the internal structure of small objects [1,2]. Its biological and medical applications include noninvasively screening animals for genetic mutations and identification as well as monitoring of structural and physiology properties that are linked with specific genes. This paper reports on our preliminary investigation on two aspects of this new imaging technique: (1) an initial experience of instrumentation capability and limitation, and (2) the contrast enhancement strategy necessary for organ-specific anatomic and physiologic studies.
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