Journal articles: 'Genesis of the novel'

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Péterfi, Zalán, and Miklós Geiszt. "Peroxidasins: novel players in tissue genesis." Trends in Biochemical Sciences 39, no. 7 (July 2014): 305–7. http://dx.doi.org/10.1016/j.tibs.2014.05.005.

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Bertrand, Ingrid. "Genesis plural." English Text Construction 8, no. 2 (November 20, 2015): 194–206. http://dx.doi.org/10.1075/etc.8.2.03ber.

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This article is devoted to Jenny Diski’s polyphonic rewriting of the biblical myth of Abraham and Sarah in Only Human: A Divine Comedy (2000). It shows how this subversive novel, through its juxtaposition of two competing narrative voices – an unidentified human narrator and God himself –, challenges the omniscience and transcendence usually attributed to God, but also the power of his creative Word, and launches a reflection on storytelling and truth, presenting thereby an “only human” Bible.

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Musaіуeva, Irada. "Genesis of the Novel in Classical Azerbaijani Literature." Bulletin of L.N. Gumilyov Eurasian National University. Philology Series 128, no. 3 (2019): 30–43. http://dx.doi.org/10.32523/2616-678x-2019-128-3-30-43.

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Hale, Elizabeth. "Examining Humanity in Bernard Beckett’s Genesis." Clotho 2, no. 2 (December 18, 2020): 103–25. http://dx.doi.org/10.4312/clotho.2.2.103-125.

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New Zealand author Bernard Beckett’s young adult novel Genesis (2006) blends classical philosophy and Gothic tropes in a dystopian novel about the nature and ends of humanity. It is a curious work, presented in the form of philosophical dialogue and set in a future world known as The Republic, in which robots have triumphed over humanity and formed a new society based on rational order. Yet sinister underpinnings to their society and their emotional origin-story, which forms the core of this novel, show both that their rational world order is built on lies, deception, and murder, and that the human soul is harder to be rid of than they imagine. The clash between robots and humans is depicted as a clash between reason and passion, and also as a clash between a classical calm (seen in the Republic’s emphasis on classical philosophy) and the Gothic emotions associated with the dark, but emotional, side of humanity. Genesis is a compelling reflection on the nature of the human soul, aimed at young readers. This paper will trace how that reflection plays out through Beckett’s use of classical and Gothic ideals in an unusually thought-provoking dystopian work for young readers.

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Sestito, Simona, Sara Chiarugi, Eleonora Margheritis, Massimiliano Runfola, Simone Bertini, Gianpiero Garau, and Simona Rapposelli. "Novel Dual PDK1/AurK-A Inhibitors for Cancer Therapy: Med Chem Evolution and Crystallographic Investigation." Proceedings 22, no. 1 (August 8, 2019): 45. http://dx.doi.org/10.3390/proceedings2019022045.

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Kramer, Jeffrey A., and Stephen A. Krawetz. "Genesis of a novel human sequence from the protamine PRM1 gene." Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 120, no. 3 (October 1998): 467–73. http://dx.doi.org/10.1016/s0742-8413(98)10062-2.

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No authorship indicated. "Review of Individual Development and Evolution: The Genesis of Novel Behavior." Contemporary Psychology: A Journal of Reviews 37, no. 10 (October 1992): 1102. http://dx.doi.org/10.1037/031546.

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Luo, Ping, Meiling Yan, Edward D. Frohlich, Jawahar L. Mehta, and Changping Hu. "Novel Concepts in the Genesis of Hypertension: Role of LOX-1." Cardiovascular Drugs and Therapy 25, no. 5 (September 13, 2011): 441–49. http://dx.doi.org/10.1007/s10557-011-6337-1.

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Ageeva, Yulia, Oleg Evseev, Oleg Melichev, and Valery Rubakov. "Horndeski Genesis: strong coupling and absence thereof." EPJ Web of Conferences 191 (2018): 07010. http://dx.doi.org/10.1051/epjconf/201819107010.

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We consider Genesis in Horndeski theory as alternative to or completion of inflationary scenario. One of the options free of instabilities at all comological epochs is putative strong coupling regime at the early Genesis stage. We address this issue to see whether classical field theory description of the background evolution at this early stage is consistent, nevertheless. We argue that, indeed, despite naive strong coupling, classical analysis is legitimate in a certain range of parameters. This opens up a posibility of a novel scenario for the beginning of the cosmological expansion.

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Köhnlein, Björn. "A tonal semi-reversal in Franconian dialects." NOWELE / North-Western European Language Evolution 68, no. 1 (March 13, 2015): 81–112. http://dx.doi.org/10.1075/nowele.68.1.03koh.

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This paper examines the genesis of a tonal semi-reversal in Franconian tone accent dialects, the so-called Rule A vs. Rule B. Contrary to the traditional assumption, the reversal takes place only under declarative intonation, but not in interrogatives. To account for the semi-reversal, I provide a scenario in which Rule A and Rule B derive from a common predecessor system, which I refer to as Rule 0. These novel findings have important consequences for our understanding of the accent genesis in general: I argue that a combination of my approach for the split with duration-based genesis scenarios leads to a plausible account. As the paper discusses in detail, it is problematic to adapt (previous) alternative proposals to the full data set.

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James, David. "Localizing Late Modernism: Interwar Regionalism and the Genesis of the “Micro Novel”." Journal of Modern Literature 32, no. 4 (July 2009): 43–64. http://dx.doi.org/10.2979/jml.2009.32.4.43.

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Zhu, Feng, Shengguo Xue, William Hartley, Ling Huang, Chuan Wu, and Xiaofei Li. "Novel predictors of soil genesis following natural weathering processes of bauxite residues." Environmental Science and Pollution Research 23, no. 3 (October 10, 2015): 2856–63. http://dx.doi.org/10.1007/s11356-015-5537-9.

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Boretti, Alberto, and Stefania Castelletto. "Novel hypotheses for the genesis of hydrocarbon fuels from carbon and hydrogen." International Journal of Hydrogen Energy 38, no. 13 (May 2013): 5285–87. http://dx.doi.org/10.1016/j.ijhydene.2013.02.099.

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Martín Párraga, Javier. "Roughing It in the Bush, The Graphic Novel." Revista Canaria de Estudios Ingleses, no. 81 (2020): 321–34. http://dx.doi.org/10.25145/j.recaesin.2020.81.21.

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Graphic novels and comic books are no longer minor cultural artifacts which are produced to generate economic benefits, mostly consumed by young, not very literate, readers who do not hope to be educated but simply entertained. Quite on the contrary, authors such as Will Eisner, Art Spiegelman, Alan Moore, Neil Gaiman or Umberto Eco has vindicated the fundamental role these artistic manifestations play nowadays. The present paper analyzes Carol Shields and Patrick Crowe 2016 graphic novel adaptation of Susanna Moodie’s seminal book Roughing it in the Bush. In order to reach this goal, a brief theoretical state of the art is introduced. Consequently, the original writer and text are equally studied. Finally, the contemporary graphic novel adaptation is considered, explaining the genesis of the project as well and the similitudes and differences it shows when compared to the original work by Susanna Moodie.

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Baranova, Juliana, Dominik Büchner, Werner Götz, Margit Schulze, and Edda Tobiasch. "Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?" International Journal of Molecular Sciences 21, no. 11 (June 4, 2020): 4031. http://dx.doi.org/10.3390/ijms21114031.

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With increasing life expectancy, demands for dental tissue and whole-tooth regeneration are becoming more significant. Despite great progress in medicine, including regenerative therapies, the complex structure of dental tissues introduces several challenges to the field of regenerative dentistry. Interdisciplinary efforts from cellular biologists, material scientists, and clinical odontologists are being made to establish strategies and find the solutions for dental tissue regeneration and/or whole-tooth regeneration. In recent years, many significant discoveries were done regarding signaling pathways and factors shaping calcified tissue genesis, including those of tooth. Novel biocompatible scaffolds and polymer-based drug release systems are under development and may soon result in clinically applicable biomaterials with the potential to modulate signaling cascades involved in dental tissue genesis and regeneration. Approaches for whole-tooth regeneration utilizing adult stem cells, induced pluripotent stem cells, or tooth germ cells transplantation are emerging as promising alternatives to overcome existing in vitro tissue generation hurdles. In this interdisciplinary review, most recent advances in cellular signaling guiding dental tissue genesis, novel functionalized scaffolds and drug release material, various odontogenic cell sources, and methods for tooth regeneration are discussed thus providing a multi-faceted, up-to-date, and illustrative overview on the tooth regeneration matter, alongside hints for future directions in the challenging field of regenerative dentistry.

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Baraban, Elena, and Victor Terras. "A Karamazov Companion: Commentary on the Genesis, Language, and Style of Dostoevsky's Novel." Rocky Mountain Review of Language and Literature 57, no. 2 (2003): 76. http://dx.doi.org/10.2307/1348400.

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Backscheider, Paula R. "Sex, Sin and Ideology: The Drama's Gift to the Genesis of the Novel." Lumen: Selected Proceedings from the Canadian Society for Eighteenth-Century Studies 12 (1993): 1. http://dx.doi.org/10.7202/1012574ar.

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Davaadelger, Batzaya, Hong Shen, and Carl G. Maki. "Novel Roles for P53 in the Genesis and Targeting of Tetraploid Cancer Cells." PLoS ONE 9, no. 11 (November 7, 2014): e110844. http://dx.doi.org/10.1371/journal.pone.0110844.

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Pu, Juan, Shuoguo Wang, Yanbo Yin, Guozhong Zhang, Robert A. Carter, Jinliang Wang, Guanlong Xu, et al. "Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus." Proceedings of the National Academy of Sciences 112, no. 2 (December 29, 2014): 548–53. http://dx.doi.org/10.1073/pnas.1422456112.

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The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant’s internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010–2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential.

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Ascari, Maurizio. "Am I Doing the Right Thing?" European Journal of Life Writing 3 (July 25, 2014): C71—C86. http://dx.doi.org/10.5463/ejlw.3.117.

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This article describes the genesis of Faded Letters, a novel that is rooted in real facts, notably, tracing the fate of Antonio Ascari, who was deported to Germany in 1944 as a forced labourer and died in Lublin in 1945, while fleeing from Germany with other Italian prisoners.

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Davis, Christopher A. "The Formation of Moist Vortices and Tropical Cyclones in Idealized Simulations." Journal of the Atmospheric Sciences 72, no. 9 (September 1, 2015): 3499–516. http://dx.doi.org/10.1175/jas-d-15-0027.1.

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Abstract The upscale aggregation of convection is used to understand the emergence of rotating, coherent midtropospheric structures and the subsequent process of tropical cyclone formation. The Cloud Model, version 1 (CM1), is integrated on an f plane with uniform sea surface temperature (SST) and prescribed uniform background flow. Deep convection is maintained by surface fluxes from an ocean with uniform surface temperature. Convection begins to organize simultaneously into moist and dry midtropospheric patches after 10 days. After 20 days, the patches begin to rotate on relatively small scales. Moist cyclonic vortices merge, eventually forming a single dominant vortex that subsequently forms a tropical cyclone on a realistic time scale of about 5 days. Radiation that interacts with clouds and water vapor aids in forming coherent rotating structures. Using the path to genesis provided by the aggregated solution, the relationship between thermodynamic changes within the vortex and changes in the character of convection prior to genesis is explored. Consistent with previous studies, the approach to saturation within the midtropospheric vortex accelerates the genesis process. A novel result is that, prior to genesis, downdrafts become widespread and somewhat stronger. The increased downdraft mass flux leads to stronger and larger surface cold pools. Shear–cold pool dynamics promote the organization of lower-tropospheric updrafts that spin up the surface vortex. It is inferred that the observed inconsistency between convective intensity and thermodynamic stabilization prior to genesis results from sampling limitations of the observations wherein the important cold pool gradients are unresolved.

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Fokin, S. L. "Marcel Proust on screen. Film as a novel. Novel as a translation." Voprosy literatury, no. 2 (July 29, 2020): 167–82. http://dx.doi.org/10.31425/0042-8795-2020-2-167-182.

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The author of Ala Recherchedu Temps Perdu, M. Proust was certainly a man of his time, which was coincidentally the beginning of the cinematic age. Therefore, it remains a relevant scholarly task to recognize the virtual connections between Proust’s poetics and filmmaking techniques: a problem S. Fokin is trying to solve in this article. Here, he focuses less on the principles of a strictly philological analysis that centres on textual elements, intertextual aspects or the book’s genesis, but prefers instead to delve into elements of literary anthropology, with its preoccupation with the unity between the author, the text and the context, which does not rule out the use of literature as a tool for comprehension of a literary personality. Such an assumption does not reduce literature to life: an opponent of Sainte-Beuve’s biographical method, Proust, for one, would not tolerate it; but neither does it reduce literature to a text as a self-sufficient structure: this position sees the book as co-substantial to the author. To summarize the findings, in order to understand Proust’s view of the cinematic art, one should remember that his almost snobbish dismissal of the meaning and significance of motion pictures was just as typical of the author as his aristocratic ideas about the meaning of literature.

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Makarychev, Aleksei. "The genesis of the creativity of Yuri Dombrovsky in novel “The Birth of Mous." Current Issues in Philology and Pedagogical Linguistics 36, no. 4 (December 25, 2019): 171–77. http://dx.doi.org/10.29025/2079-6021-2019-4-171-177.

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Helfer, Martha B., and Ehrhard Bahr. "The Novel as Archive: The Genesis, Reception, and Criticism of Goethe's "Wilhelm Meisters Wanderjahre"." German Studies Review 24, no. 1 (February 2001): 164. http://dx.doi.org/10.2307/1433164.

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Drickamer, Lee C. "Review by Individual Development & Evolution. The Genesis of Novel Behaviour, by G. Gottlieb." Animal Behaviour 46, no. 1 (July 1993): 207–8. http://dx.doi.org/10.1006/anbe.1993.1180.

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Mallo, Moisés. "A Novel Possible Mechanism for the Genesis of Genomic Duplications and Its Experimental Test." Journal of Molecular Evolution 61, no. 3 (July 28, 2005): 390–97. http://dx.doi.org/10.1007/s00239-004-0303-5.

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Kujawska-Lis, Ewa. "Kilka uwag o mutowaniu postaci fikcyjnych i recepcji tekstów kultury na przykładzie powieści Alienista Caleba Carra i jej serialowej adaptacji." Acta Neophilologica 2, no. XXI (December 1, 2019): 127–40. http://dx.doi.org/10.31648/an.4751.

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The Alienist, a TV series released in 2018, is based on Caleb Carr’s best-sell-ing novel published in 1994. Irrespective of its genesis as an adaptation, presently the TV series generates new senses when watched from the perspective of works that have appeared in visual culture since the publication of the book. This paper sets to demonstrate to what extent the original novel and later the TV production create a mutation of a well-known pair of detectives (Sherlock/Watson) and how the reception of the series may differ from that of the original novel.

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Thagazitov, Yuriy M., Almira M. Kazieva, and Fatima T. Uzdenova. "Genesis of the novelty thinking in Russian language Kabardinian literature of the 80s of the 20th century." Philological Sciences. Scientific Essays of Higher Education, no. 4 (July 2021): 131–36. http://dx.doi.org/10.20339/phs.4-21.131.

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The article is an attempt to “re-read and rethink” the novels of Russian-speaking Kabardian writer M. Elberd “Terrible way to Oshkhamakho” and “Look for where you didn’t hide” at the level of modern literary experience. The authors focus on the complex, multifaceted interweaving of a single, essentially self-national and Russian-language literary process. This approach allows us to see new facets of artistic and sociocultural interrelations in the evolution of novel thinking. The particular interest of the Russian-language novel in history is connected with the important problem of how people choose their own destiny. The most important criterion in the North Caucasian Russian-speaking Romanticism remains the widespread world perception of the people: this circumstance emphasizes the importance of the orientation of Kabardian literature of the 80s of the 20th century to folk mythology, Adyg etiquette, the cycle of legends about Zhabagi Kazanoko, enlightenment, creativity of the classics of Kabardian literature Ali Shogentsukov and A. Keshokov. The article uses an integrated approach. It combines elements of typological, systemic-holistic and historical-literary analysis. The research methods are structural-analytical, synchronous-comparative, hermeneutic.

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Ahokas, Pirjo. "Jewish/Christian symbolism in Bernard Malamud's novel God's grace." Nordisk Judaistik/Scandinavian Jewish Studies 7, no. 2 (September 1, 1986): 84–91. http://dx.doi.org/10.30752/nj.69408.

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Besides being one of the major American authors of the postwar period, Bernard Malamud is also one of the leading representatives of contemporary Jewish fiction. When God's Grace was published, it received very mixed reviews and the novel is likely to remain one of Malamud’s most controversial books. Part of the audience’s puzzlement derives from the fact that with its grotesque characters and strange events God’s Grace seems to defy definition. The novel is filled with literary references and biblical symbolism that mainly draws on Genesis and on the apocalyptic tradition fused with elements of Messianism. The author discusses the genre problem of God’s Grace by outlining some of its background in contemporary America fiction and then analyzing the meaning and effect of Malamud’s use of Jewish/Christian symbolism to enhance the valuable aspects of the Jewish inheritance.

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Lohani, Subash, and Alan R. Cohen. "Franc D. Ingraham and the genesis of pediatric neurosurgery." Journal of Neurosurgery: Pediatrics 11, no. 6 (June 2013): 727–33. http://dx.doi.org/10.3171/2013.3.peds12476.

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In 1929, Franc D. Ingraham, Harvey Cushing's protégé, established the first pediatric neurosurgical unit in the world at Boston Children's Hospital and dedicated his career to the neurosurgical care of children. He trained with both Cushing and Dandy and spent 1 year working in Oxford with Sherrington, who considered Ingraham to be the finest operative surgeon ever to work in his laboratory. Ingraham was instrumental in developing novel treatments, which he compiled in his classic book, Neurosurgery of Infancy and Childhood. Although he was modest and shy, Ingraham loved to entertain children with magic and enjoyed photography in and out of the operating room. Unfortunately, his career was plagued by personal illness, and he died young in 1965 at the age of 67. Despite his prolific 36-year neurosurgical career, Ingraham remained an associate professor at Harvard at his retirement. To recognize his remarkable contributions, Harvard established an endowed chair in his name in 1967. Ingraham was a pioneer and a leader in the development of pediatric neurosurgery by virtue of his imagination, intelligence, and ability to lead and inspire others. Cushing has come to be regarded as the founder of neurosurgery. It is fair to conclude that Ingraham, his disciple, is the founder of pediatric neurosurgery.

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Selkoe, Dennis J. "Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease." Journal of Clinical Investigation 110, no. 10 (November 15, 2002): 1375–81. http://dx.doi.org/10.1172/jci0216783.

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Gratze, Petra, Ralf Dechend, Carolin Stocker, Joon-Keun Park, Sandra Feldt, Erdenechimeg Shagdarsuren, Maren Wellner, et al. "Novel Role for Inhibitor of Differentiation 2 in the Genesis of Angiotensin II–Induced Hypertension." Circulation 117, no. 20 (May 20, 2008): 2645–56. http://dx.doi.org/10.1161/circulationaha.107.760116.

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Zhang, Zongchao, Fernando A. P. Cavalcanti, and Wolfgang M. H. Sachtler. "Catalysts by design: genesis and CO hydrogenation of novel Pd carbonyl clusters in zeolite 5A." Catalysis Letters 12, no. 1-3 (1992): 157–69. http://dx.doi.org/10.1007/bf00767198.

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Hernández Lobato, Jesús. "Baroja y el "Génesis": hacia una lectura hipertextual de "El árbol de la ciencia"." Tropelías: Revista de Teoría de la Literatura y Literatura Comparada, no. 15-17 (February 26, 2011): 351. http://dx.doi.org/10.26754/ojs_tropelias/tropelias.200415-1715.

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Este artículo se propone ofrecer una relectura global de El árbol de la ciencia a partir de un análisis pormenorizado de su rico diálogo hipertextual con el libro del Génesis y la literatura europea en su conjunto. A lo largo de dicha novela Baroja se las ingenia para diseminar una serie de pistas o índices intertextuales que permitan al lector atento reconstruir el significado alegórico de la obra, que va mucho más allá de sus aspectos autobiográficos, filosóficos o socio-históricos, tema principal de buen número de los artículos y estudios precedentes. Esta novedosa mirada a la interacción polifónica de discursos literarios superpuestos (concernientes a la tradición exegética occidental, el esoterismo judío o la tópica medieval) con el texto bíblico del Génesis nos ofrece una visión más amplia y matizada del significado (o significados) de la novela, siempre abierto a sorprendentes juegos de reformulación alusiva y revisión crítica del material heredado.This paper aims to provide a new overall reading of El árbol de la ciencia by means of a detailed analysis of its rich hypertextual dialogue with the book of Genesis and European literature as a whole. All through his novel Baroja manages to spread a set of clues or intertextual indications that let the attentive reader reconstruct the allegorical meaning of his work, beyond its merely autobiographical, philosophical or sociohistorical aspects, which have been largely the main topic of so many papers and studies before. This new look at the polyphonic interplay between literary discourses (regarding western exegetical tradition, Jewish or medieval commonplaces) and the biblical text of Genesis provides us a more extensive and nuanced point of view about the meaning(s) of the novel, always open to the most surprising games of allusive reutterance and critical review of inherited material.

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SAVAGE, GARY. "NOVEL NARRATIVES, NEW RESEARCH: THE FRENCH REVOLUTION AFTER THE BICENTENNIAL." Historical Journal 40, no. 1 (March 1997): 241–52. http://dx.doi.org/10.1017/s0018246x96006929.

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Revolution and political conflict in the French navy, 1789–1794. By William S. Cormack. Cambridge: Cambridge University Press, 1995. Pp. 343. £40.00.The family romance of the French revolution. By Lynn Hunt. London: Routledge, 1992. Pp. 213. £19.99.The French idea of freedom: the old regime and the Declaration of Rights of 1789. Edited by Dale Van Kley. Stanford: Stanford University Press, 1995. Pp. 436. £35.00.A rhetoric of bourgeois revolution: the Abbé Sieyes and What is the third estate ? By William H. Sewell, Jr. Durham and London: Duke University Press, 1994. Pp. 221. £10.95.The genesis of the French revolution: a global-historical interpretation. By Bailey Stone. Cambridge: Cambridge University Press, 1995. Pp. 268. £12.95.The new regime: transformations of the French civic order, 1789–1820s. By Isser Woloch. New York and London: W. W. Norton, 1994. Pp. 536. £27.50.

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Silberstein, SD. "Tonabersat, A Novel Gap-Junction Modulator for the Prevention of Migraine." Cephalalgia 29, no. 2_suppl (November 2009): 28–35. http://dx.doi.org/10.1111/j.1468-2982.2009.01973.x.

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Migraine is a common, recurrent, primary headache disorder associated with significant morbidity as well as high direct and indirect costs. Despite its impact, only a proportion of migraineurs who meet criteria for prophylactic treatment take preventive medication. Antiepileptic drugs and β-blockers are among the most used preventive therapies, but their exact mechanisms of action in migraine prophylaxis are unknown. Recent research has pointed to the role of cortical spreading depression in the genesis of migraine aura and pain, with neuronalglial gap junctions playing a prominent part in cortical spreading depression. Tonabersat is a unique compound with demonstrated activity as a gap-junction inhibitor in animal studies. In preclinical and clinical trials, tonabersat was well tolerated, with no cardiovascular effects; the pharmacokinetic profile suggested its usefulness in the prophylaxis of migraine.

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Sharapova, D. D. "“THE IDIOT” BY F. M. DOSTOYEVSKY AND “LES MYSTERES DE PARIS” BY EUGENE SUE: COMMON GROUNDS." Bulletin of Kemerovo State University, no. 4 (November 26, 2016): 228–32. http://dx.doi.org/10.21603/2078-8975-2016-4-228-232.

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The article is about the influence of the “roman-feuilleton” on the novel “The Idiot” by F. M. Dostoyevsky. The article features a number of selected heroes (Nastasiya Filippovna and prince Myshkin) and situations which have analogues with the novel “Les mysteres de Paris” by Eugene Sue and the genre of “romanfeuilleton” (for example, repeated scandals, which are very important for the story, coincidences, parentlessness of the main heroes, love triangles, numerous dramatic scenes and storylines). Also, the author of the article analyzes the genesis of the feuilleton motifs and the varieties that were left by Dostoyevsky as plans and drafts only.

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Pulkkinen, Veijo. "The Diary, the Typewriter and Representative Reality in the Genesis of Juha Mannerkorpi's Päivänsinet." European Journal of Life Writing 9 (April 10, 2020): 1–21. http://dx.doi.org/10.21827/ejlw.9.35712.

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This article investigates the transition from keeping a diary to writing a future published work with reference to the genetic process of Päivänsinet: muuan loppukesän merkintöjä (1979) by Finnish author and translator Juha Mannerkorpi. The diary novel is about a seriously ill narrator who watches the growth of a morning glory, meticulously counting, measuring and registering the daily unravelling flowers with the help of a typewriter. In combining genetic criticism with Philippe Lejeune’s ideas on the diary, antifiction and the diary effect, the article analyses the frequent metapoetic remarks upon the use of the typewriter and the relationship between fact and fiction in the context of the diary-writing process and its subsequent rewriting as a novel. Upon close inspection of the manuscripts it becomes clear that the typewriter was not a transparent medium that helped the weak-sighted author to write, but that the physical act of typing influenced the content of Mannerkorpi’s text in many respects. In addition to shedding light on many experimental features of Mannerkorpi’s works, this study on the genesis of Päivänsinet widens current understanding concerning the impact of writing tools on diary-keeping and literary writing.

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SooJeong Shin. "A Narrative of the Endig and Genesis of Humanity - Apocalyptic Imagination in 2000's Korean Novel -." 한국문예비평연구 ll, no. 35 (August 2011): 283–314. http://dx.doi.org/10.35832/kmlc..35.201108.283.

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Desouky, Hamdy El, Jeroen Soete, Hannes Claes, Mehmet Özkul, Frank Vanhaecke, and Rudy Swennen. "Novel applications of fluid inclusions and isotope geochemistry in unravelling the genesis of fossil travertine systems." Sedimentology 62, no. 1 (December 5, 2014): 27–56. http://dx.doi.org/10.1111/sed.12137.

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Prasad, S. D. "A Novel Two-Parameter Biexponential Distribution To Map Surface Heterogeneity: Genesis of Common Distributions and Isotherms†." Langmuir 13, no. 5 (March 1997): 1307–16. http://dx.doi.org/10.1021/la950544s.

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Haralampiev, Ivan, Simon Prisner, Matthias Schade, Jasmine Chamiolo, Fabian Jolmes, Oliver Seitz, and Andreas Herrmann. "Tracking the Switch of Influenza RNA Genesis by a Novel Multiplexed Fish Method in Single Cells." Biophysical Journal 110, no. 3 (February 2016): 486a. http://dx.doi.org/10.1016/j.bpj.2015.11.2600.

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Conde, Javier, Morena Scotece, Rodolfo Gómez, Veronica Lopez, Juan Jesus Gómez-Reino, and Oreste Gualillo. "Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease." Arthritis 2011 (August 18, 2011): 1–8. http://dx.doi.org/10.1155/2011/203901.

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Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases.

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Adameova, Adriana, Anureet K. Shah, and Naranjan S. Dhalla. "Role of Oxidative Stress in the Genesis of Ventricular Arrhythmias." International Journal of Molecular Sciences 21, no. 12 (June 12, 2020): 4200. http://dx.doi.org/10.3390/ijms21124200.

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Ventricular arrhythmias, mainly lethal arrhythmias, such as ventricular tachycardia and fibrillation, may lead to sudden cardiac death. These are triggered as a result of cardiac injury due to chronic ischemia, acute myocardial infarction and various stressful conditions associated with increased levels of circulating catecholamines and angiotensin II. Several mechanisms have been proposed to underlie electrical instability of the heart promoting ventricular arrhythmias; however, oxidative stress which adversely affects ion homeostasis due to changes in the ion channel structure and function, seems to play a critical role in eliciting different types of ventricular arrhythmias. Prevention or mitigation of the severity of ventricular arrhythmias due to antioxidants has been indicated as the fundamental contribution in the field of preventive cardiology; however, novel interventions have to be developed for greater effectiveness and specificity in attenuating the adverse effects of oxidative stress. In this review, we have attempted to discuss proarrhythmic effects of oxidative stress differing in time and concentration dependence and highlight a molecular and cellular concept how it alters cardiac cell automaticity and conduction velocity sensitizing the probability of ventricular arrhythmias with resultant sudden cardiac death due to ischemic heart disease and other stressful situations. It is concluded that pharmacological approaches targeting multiple mechanisms besides oxidative stress might be more effective in the treatment of ventricular arrhythmias than current antiarrhythmic therapy.

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Hunt, Barry. "Knowledge-Based Nonlinear Boundary Integral Models of Compressible Viscous Flows Over Arbitrary Bodies: Taking CFD Back to Basics." Applied Mechanics Reviews 44, no. 11S (November 1, 1991): S130—S142. http://dx.doi.org/10.1115/1.3121345.

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The paper starts with a discussion of a knowledge-based CFD methodology. A new incompressible formulation known as SAVER is first introduced, employing a novel relaxation approach. This is then generalized through a modification of the boundary conditions to the GENESIS methodology, for analysis or design in compressible, rotational flow. A discussion is presented of how the basic causal nature of integral methods offers new insights into certain flow phenomena, such as shocks and separations, and facilitates aerodynamic sensitivity analysis. The paper presents a new class of vector fields approximating the Euler equations for transonic flows, and shows how GENESIS can be used to construct first an exact solution of these approximate fields, then a numerical solution of the residual error fields. The explicit representation of a shock discontinuity on the body boundary exploits its causal link with conditions at the sonic point to suppress, non-dissipatively, the mathematically-valid but physically-impossible formation of an expansion shock.

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Croci-Maspoli, M., C. Schwierz, and H. C. Davies. "A Multifaceted Climatology of Atmospheric Blocking and Its Recent Linear Trend." Journal of Climate 20, no. 4 (February 15, 2007): 633–49. http://dx.doi.org/10.1175/jcli4029.1.

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Abstract A dynamically based climatology is derived for Northern Hemisphere atmospheric blocking events. Blocks are viewed as large amplitude, long-lasting, and negative potential vorticity (PV) anomalies located beneath the dynamical tropopause. The derived climatology [based on the 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40)] provides a concise, coherent, and illuminating description of the main physical characteristics of blocks and the accompanying linear trends. The latitude–longitude distribution of blocking frequency captures the standard bimodal geographical distribution with major peaks over the North Atlantic and eastern North Pacific in all four seasons. The accompanying pattern for the age distribution, the genesis–lysis regions, and the track of blocks reveals that 1) younger blocks (1–4 days) are more prevalent at lower latitudes whereas significantly older blocks (up to 12 days) are located at higher latitudes; 2) genesis is confined predominantly to the two major ocean basins and in a zonal band between 40° and 50°N latitude, whereas lysis is more dispersed but with clear preference to higher latitudes; and 3) the general northeastward–west-northwest movement of blocks in the genesis–lysis phase also exhibits subtle seasonal and intra- and interbasin differences. Examination of the intensity and spatial-scale changes during the blocking life cycle suggests that in the mean a block’s evolution is independent of the genesis region and its eventual duration. A novel analysis of blocking trends reveals significant negative trends in winter over Greenland and in spring over the North Pacific. It is shown that the changes over Greenland are linked to the number of blocking episodes, whereas a neighboring trend signal to the south is linked to higher-frequency anticyclonic systems. Furthermore, evidence is adduced that changes in blocking frequency contribute seminally to tropopause height trends.

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Szmidt, Maciej, Kaja Urbańska, Marta Grodzik, Piotr Orłowski, Ewa Sawosz, Mateusz Wierzbicki, and Paweł Sysa. "Morphology of Human Glioblastoma Model Cultured in Ovo." Bulletin of the Veterinary Institute in Pulawy 56, no. 2 (June 1, 2012): 261–66. http://dx.doi.org/10.2478/v10213-012-0046-9.

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Abstract The aim of this study was the morphological characterisation of glioblastoma multiforme tumour grown in ovo. Tumour cells (U-87 MG) were implanted on the chorioallantoic membrane of chicken egg. The structural features of cultured tumours resembled the spontaneous glioblastoma multiforme; however, the differences were also indicated. Our results confirm applicability of in ovo culture in tumour genesis studies. The described novel model may be profoundly helpful for the future research on molecular mechanisms of tumour growth inhibition.

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Lavoz, Carolina, Sandra Rayego-Mateos, Macarena Orejudo, Lucas Opazo-Ríos, Vanessa Marchant, Laura Marquez-Exposito, Antonio Tejera-Muñoz, et al. "Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy?" Journal of Clinical Medicine 9, no. 1 (January 19, 2020): 272. http://dx.doi.org/10.3390/jcm9010272.

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Chronic kidney disease has become a major medical issue in recent years due to its high prevalence worldwide, its association with premature mortality, and its social and economic implications. A number of patients gradually progress to end-stage renal disease (ESRD), requiring then dialysis and kidney transplantation. Currently, approximately 40% of patients with diabetes develop kidney disease, making it the most prevalent cause of ESRD. Thus, more effective therapies for diabetic nephropathy are needed. In preclinical studies of diabetes, anti-inflammatory therapeutic strategies have been used to protect the kidneys. Recent evidence supports that immune cells play an active role in the pathogenesis of diabetic nephropathy. Th17 immune cells and their effector cytokine IL-17A have recently emerged as promising targets in several clinical conditions, including renal diseases. Here, we review current knowledge regarding the involvement of Th17/IL-17A in the genesis of diabetic renal injury, as well as the rationale behind targeting IL-17A as an additional therapy in patients with diabetic nephropathy.

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Makhliyo, Erkinovna Khabibullaeva. "Experience Of Translating Historical Novels In Translation Studies." American Journal of Social Science and Education Innovations 03, no. 06 (June 20, 2021): 84–90. http://dx.doi.org/10.37547/tajssei/volume03issue06-14.

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This article deals with the experience of translating historical novels in translation studies. It provides a comparative analysis of the specific methods of the Uzbek national school of translation studies and the world schools of translation. Moreover, the genesis of translation of Uzbek historical novels, methods of translation, especially the problem of technique in the translation into English, and certain peculiarities of translating historical works are studied here on a scientific basis. As a result, a number of scientific and practical recommendations are given to improve the mechanisms of forming professional competence in the practice of translating historical novels, with the experimental trends of world translation schools taken into account.

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Roos, A., A. Topf, V. Phan, J. Gonzalez Coraspe, M. Hauessler, J. Weis, H. Lochmüller, and N. Kohlschmidt. "Insights into the genesis of a brain and muscle disorder caused by a novel mutation in MICU1." Neuromuscular Disorders 27 (October 2017): S117. http://dx.doi.org/10.1016/j.nmd.2017.06.094.

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Journal articles on the topic 'Genesis of the novel'

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