Dissertations / Theses on the topic 'Generation of negative triples'
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Vitiello, Adriana. "Generation and characterization of HSV-1 based oncolytic viruses towards an innovative therapeutic approach for TNBC." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3422208.
Vougiouklis, Pavlos. "Neural generation of textual summaries from knowledge base triples." Thesis, University of Southampton, 2019. https://eprints.soton.ac.uk/428045/.
Islam, Md Kamrul. "Explainable link prediction in large complex graphs - application to drug repurposing." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0203.
Many real-world complex systems can be well-represented with graphs, where nodes represent objects or entities and links/relations represent interactions between pairs of nodes. Link prediction (LP) is one of the most interesting and long-standing problems in the field of graph mining; it predicts the probability of a link between two unconnected nodes based on available information in the current graph. This thesis studies the LP problem in graphs. It consists of two parts: LP in simple graphs and LP knowledge graphs (KGs). In the first part, the LP problem is defined as predicting the probability of a link between a pair of nodes in a simple graph. In the first study, a few similarity-based and embedding-based LP approaches are evaluated and compared on simple graphs from various domains. he study also criticizes the traditional way of computing the precision metric of similarity-based approaches as the computation faces the difficulty of tuning the threshold for deciding the link existence based on the similarity score. We proposed a new way of computing the precision metric. The results showed the expected superiority of embedding-based approaches. Still, each of the similarity-based approaches is competitive on graphs with specific properties. We could check experimentally that similarity-based approaches are fully explainable but lack generalization due to their heuristic nature, whereas embedding-based approaches are general but not explainable. The second study tries to alleviate the unexplainability limitation of embedding-based approaches by uncovering interesting connections between them and similarity-based approaches to get an idea of what is learned in embedding-based approaches. The third study demonstrates how the similarity-based approaches can be ensembled to design an explainable supervised LP approach. Interestingly, the study shows high LP performance for the supervised approach across various graphs, which is competitive with embedding-based approaches.The second part of the thesis focuses on LP in KGs. A KG is represented as a collection of RDF triples, (head,relation,tail) where the head and the tail are two entities which are connected by a specific relation. The LP problem in a KG is formulated as predicting missing head or tail entities in a triple. LP approaches based on the embeddings of entities and relations of a KG have become very popular in recent years, and generating negative triples is an important task in KG embedding methods. The first study in this part discusses a new method called SNS to generate high-quality negative triples during the training of embedding methods for learning embeddings of KGs. The results we produced show better LP performance when SNS is injected into an embedding approach than when injecting state-of-the-art negative triple sampling methods. The second study in the second part discusses a new neuro-symbolic method of mining rules and an abduction strategy to explain LP by an embedding-based approach utilizing the learned rules. The third study applies the explainable LP to a COVID-19 KG to develop a new drug repurposing approach for COVID-19. The approach learns ”ensemble embeddings” of entities and relations in a COVID-19 centric KG, in order to get a better latent representation of the graph elements. For the first time to our knowledge, molecular docking is then used to evaluate the predictions obtained from drug repurposing using KG embedding. Molecular evaluation and explanatory paths bring reliability to prediction results and constitute new complementary and reusable methods for assessing KG-based drug repurposing. The last study proposes a distributed architecture for learning KG embeddings in distributed and parallel settings. The results of the study that the computational time of embedding methods improves remarkably without affecting LP performance when they are trained in the proposed distributed settings than the traditional centralized settings
Genz, Adrian P. "Operational Amplifier Bandwidth Extension Using Negative Capacitance Generation." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1383.pdf.
Thilleul, Olivia. "Negative lift generation in a tidal device structure." Thesis, Cranfield University, 2009. http://dspace.lib.cranfield.ac.uk/handle/1826/8292.
McLenaghan, Joanna Siân. "Negative frequency waves in optics : control and investigation of their generation and evolution." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6532.
Kharazi, Alexandra. "Generation and molecular analysis of dominant negative alleles of anthrax lethal factor in Drosophila." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1453196.
Title from first page of PDF file (viewed July 8, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 26).
Duvvury, Rolan Shawn. "Potential negative effects of wind turbines on the ear." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44927.
Agee, Elisha R. "The relationship between second-generation antipsychotic medication adherence and negative symptoms in first-episode schizophrenia." Thesis, Pepperdine University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3716463.
Adherence to psychotropic medication is a critical aspect of treatment for the management of psychotic disorders. While the literature on the need for medication adherence is extensive, little research has explored the relationship between the negative symptoms of psychosis and medication adherence. Since negative symptoms are enduring, stable, and strongly correlated with poor outcome, it is vitally important for research to explore the role of negative symptoms in regards to adherence to psychotropic medication. Given its potentially significant consequences for treatment interventions, the purpose of this study was to contribute to the exceedingly limited body of research exploring the relationship between the negative symptoms seen in psychosis and medication adherence. This study examined if there is a relationship between the two and whether causality could be determined should a significant relationship exist between medication adherence and negative symptoms. This study utilized data previously collected at the UCLA Aftercare Research Program for studies examining aspects of outpatient psychiatric treatment. The 148 participants had a mean age of 22.5 years and were in the midst of their first psychotic episode upon study entry. Data from the Brief Psychiatric Rating Scale, Scale for the Assessment of Negative Symptoms, and medication adherence ratings were collected over the course of 12 months. Analyses revealed a significant relationship between the presence of negative symptoms and medication nonadherence. Analyses examining the temporal relationship between the two variables revealed that initial medication nonadherence was significantly associated with subsequent negative symptoms. However, once the impact of positive symptoms was controlled for as a potential mediating variable, the strength of the relationship between medication adherence and negative symptoms dissipated. After controlling for the role of reality distortion, the only negative symptoms significantly associated with medication nonadherence were the BPRS Negative Symptom Factor, BPRS Emotional Withdrawal, and BPRS Self-Neglect. Consequently, it appears that negative symptoms are more strongly associated with positive symptoms than with medication adherence. Replication of these findings and further research exploring the relationship between positive and negative symptoms as they relate to medication adherence is needed in order to improve treatment interventions focused on medication adherence.
Nordeman, Emil. "Generation of Doxycycline-Inducible Cell Lines Expressing Dominant-Negative DNA Polymerase γ and Mitochondrial Helicase Twinkle Variants." Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184253.
Moscrip, Amanda Nicole. "Generation Z's Positive and Negative Attributes and the Impact on Empathy After a Community-Based Learning Experience." UNF Digital Commons, 2019. https://digitalcommons.unf.edu/etd/908.
Popov, A. K., I. S. Nefedov, S. A. Myslivets, M. I. Shalaev, and V. V. Slabko. "Nonlinear-optical Negative-index Metamaterials: Extraordinary Properties and Applications." Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35381.
Ho, Shuk-wai Amy. "Generation and characterization of transgenic mice expressing dominant negative osmotic response element binding protein (OREBP) in the brain neurons /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38348068.
Pookhao, Naruekamol. "Statistical Methods for Functional Metagenomic Analysis Based on Next-Generation Sequencing Data." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/320986.
Drury, R. G. "Trajectory generation for autonomous unmanned aircraft using inverse dynamics." Thesis, Cranfield University, 2010. http://dspace.lib.cranfield.ac.uk/handle/1826/5583.
Iwai, Akinori. "Linear and Nonlinear Functions of Plasmas in Electromagnetic Metamaterials." Kyoto University, 2019. http://hdl.handle.net/2433/242471.
Ojiambo, Melina. "Exploring political intolerance in a post-apartheid generation of South Africans : the role of intergroup threat and negative intergroup emotion." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/14568.
This study extends Gibson and Gouws ' (2003) work on threat and intolerance as well as Kuklinski, Riggle, Ottati, Schwarz and Wyer's (1991) work on the influence of emotion on people's tolerance judgements. Method: Participants were randomly assigned to two experimental groups.
Malhotra, Kyle. "CHARACTERIZATION OF TWO GENES INVOLVED IN THE GENERATION OF A NEGATIVE SIGAL GENERATED BY THE PU-43 STRAIN OF PSEUDOMONAS CEDRELLA." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192519.
Röhrs, Susanne [Verfasser], and Gerd [Akademischer Betreuer] Sutter. "A neuraminidase-negative variant of highly pathogenic avian influenza virus H5N1 : generation, characterization and use as a model for early onset of immunity / Susanne Röhrs. Betreuer: Gerd Sutter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1065610890/34.
Franco, Marla A. "Effects of Negative Climate for Diversity on Cognitive Outcomes of Latina/o College Students Attending Selective Institutions| A Comparison by Students' Gender, First-Generation College Status, and Immigrant Status." Thesis, Azusa Pacific University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10608460.
Latinas/os are the fastest-growing racial minority group in the United States, yet there is a lack of parity between their increased population and their participation rates in higher education. The economic strength and vitality of the nation require a college-educated workforce; therefore, the need to improve educational environments that support increased degree attainment among Latinas/os is imperative. Despite the disproportionately low enrollment of Latina/o college students at selective U.S. higher education institutions, research has suggested that attending these types of institutions uniquely and positively influences students’ educational and socioeconomic outcomes (Hearn & Rosinger, 2014). Using Astin’s (1991) Inputs-Environments-Outcomes (I-E-O) model, this study examined Latina/o college students’ cognitive development over time, their experiences related to perceived climate for diversity, and the effects of negatively-perceived climates for diversity on their cognitive development based on students’ gender, first-generation college status, and immigrant status. A quantitative design using the 2014 University of California Undergraduate Experience Survey (UCUES) was employed, of which system-wide data from 4,299 junior and senior level Latino/a college students were used. Inferential and regression analyses were used to examine the effects of perceived negative climate for diversity on students’ cognitive outcomes. Results indicated that Latina/o students attending selective institutions benefitted greatly in their cognitive skills development, although unique differences were found when students’ outcomes were examined by their gender, first-generation college status, and immigrant status. Perceived negative climates for diversity varied depending on students’ gender, first-generation college status, and immigrant status. Examination of the effects of students’ background characteristics and college experiences on their cognitive outcomes also varied based on their gender, first-generation college status, and immigrant status. In particular, perceived negative climates for diversity were found to have mixed effects on Latina/o college students’ GPA, yet demonstrated little to no effect on students’ cognitive skills development.
Perricone, Margherita <1987>. "Characterization of Philadelphia-negative Chronic Myeloproliferative Neoplasms: identification of novel biomarkers by Next Generation Sequencing and study of interactions between hematopoietic stem cell and the inflammatory cell micro-environment." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8358/1/PhD%20Thesis_MPerricone_final.pdf.
Ring, Josh. "Novel fabrication and testing of light confinement devices." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/novel-fabrication-and-testing-of-light-confinement-devices(51572720-0c49-482e-8523-e44ca877117f).html.
Erlach, Berit [Verfasser], George [Akademischer Betreuer] Tsatsaronis, and Mats [Akademischer Betreuer] Westermark. "Biomass upgrading technologies for carbon-neutral and carbon-negative electricity generation : techno-economic analysis of hydrothermal carbonization and comparison with wood pelletizing, torrefaction and anaerobic digestion / Berit Erlach. Gutachter: George Tsatsaronis ; Mats Westermark." Berlin : Technische Universität Berlin, 2014. http://d-nb.info/1067387064/34.
Bateman, Samuel. "Hollow core fibre-based gas discharge laser systems and deuterium loading of photonic crystal fibres." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648951.
Thomas, Fernandez. "CONTRIBUTION A L'EVALUATION DE LA TECHNIQUE DE GENERATION D'HARMONIQUE PAR FAISCEAU LASER POUR LA MESURE DES CHAMPS ELECTRIQUES DANS LES CIRCUITS INTEGRES (EFISHG)." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2009. http://tel.archives-ouvertes.fr/tel-00997396.
Efendy, Komala Inggarwati. "The nature of intra-familial conflict in large-scale privately-held family businesses in Indonesia." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/60936/1/Komala_Efendy_Thesis.pdf.
Fernandez, Thomas. "Contribution à l'évaluation de la technique de génération d'harmonique par faisceau laser pour la mesure des champs électriques dans les circuits intégrés (EFISHG)." Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13846/document.
This work concerns the elaboration of an industrial method for Single Event Effect (SEE) sensitivity testing on integrated circuits. The concerned SEEs are those produced by heavy ions and are mainly Single Event Upset (SEU) and Single Event Latchup (SEL). The original test approach chosen in this study relies on the use of infrared laser pulses striking the backside of the tested device. Laser pulse and heavy ion interaction with semiconductor materials are described and a presentation of the particle accelerator test and some former laser test methods is also given. Advantages and drawbacks of those two techniques are discussed. The developed experimental setup uses a near infrared fiber coupled Neodyme/YAG pulsed laser. Its different elements are described. Using this tool to characterise the SEU sensitivity of several modern SRAMs has allowed to define a test methodology. Its efficiency is discussed and illustrated by different experimental results
Kowalczyk, Piotr Jozef. "Validation and application of advanced soil constitutive models in numerical modelling of soil and soil-structure interaction under seismic loading." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/275675.
Kowalczyk, Piotr Jozef. "Validation and application of advanced soil constitutive models in numerical modelling of soil and soil-structure interaction under seismic loading." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/275675.
Radovich, Milan. "DECODING THE TRANSCRIPTIONAL LANDSCAPE OF TRIPLE-NEGATIVE BREAST CANCER USING NEXT GENERATION WHOLE TRANSCRIPTOME SEQUENCING." Thesis, 2012. http://hdl.handle.net/1805/2745.
Triple-negative breast cancers (TNBCs) are negative for the expression of estrogen (ER), progesterone (PR), and HER-2 receptors. TNBC accounts for 15% of all breast cancers and results in disproportionally higher mortality compared to ER & HER2-positive tumours. Moreover, there is a paucity of therapies for this subtype of breast cancer resulting primarily from an inadequate understanding of the transcriptional differences that differentiate TNBC from normal breast. To this end, we embarked on a comprehensive examination of the transcriptomes of TNBCs and normal breast tissues using next-generation whole transcriptome sequencing (RNA-Seq). By comparing RNA-seq data from these tissues, we report the presence of differentially expressed coding and non-coding genes, novel transcribed regions, and mutations not previously reported in breast cancer. From these data we have identified two major themes. First, BRCA1 mutations are well known to be associated with development of TNBC. From these data we have identified many genes that work in concert with BRCA1 that are dysregulated suggesting a role of BRCA1 associated genes with sporadic TNBC. In addition, we observe a mutational profile in genes also associated with BRCA1 and DNA repair that lend more evidence to its role. Second, we demonstrate that using microdissected normal epithelium maybe an optimal comparator when searching for novel therapeutic targets for TNBC. Previous studies have used other controls such as reduction mammoplasties, adjacent normal tissue, or other breast cancer subtypes, which may be sub-optimal and have lead to identifying ineffective therapeutic targets. Our data suggests that the comparison of microdissected ductal epithelium to TNBC can identify potential therapeutic targets that may lead to be better clinical efficacy. In summation, with these data, we provide a detailed transcriptional landscape of TNBC and normal breast that we believe will lead to a better understanding of this complex disease.
Chen, Yu-Hsiang. "Multi-Modality Plasma-Based Detection of Minimal Residual Disease in Triple-Negative Breast Cancer." Diss., 2019. http://hdl.handle.net/1805/20202.
Triple-negative breast cancers (TNBCs) are pathologically defined by the absence of estrogen, progesterone, and HER2 receptors. Compared to other breast cancers, TNBC has a relatively high mortality. In addition, TNBC patients are more likely to relapse in the first few years after treatment, and experiencing a shorter median time from recurrence to death. Detecting the presence of tumor in patients who are technically “disease-free” after neoadjuvant chemotherapy and surgery as early as possible might be able to predict recurrence of patients, and then provide timely intervention for additional therapy. To this end, I applied the analysis of “liquid biopsies” for early detection of minimal residual disease (MRD) on early-stage TNBC patients using next-generation sequencing. For the first part of this study, I focused on detecting circulating tumor DNA (ctDNA) from TNBC patients after neoadjuvant chemotherapy and surgery. First, patient-specific somatic mutations were identified by sequencing primary tumors. From these data, 82% of the patients had at least one TP53 mutation, followed by 16% of the patients having at least one PIK3CA mutation. Next, I sequenced matched plasma samples collected after surgery to identify ctDNA with the same mutations. I observed that by detecting corresponding ctDNA I was able to predict rapid recurrence, but not distant recurrence. To increase the sensitivity of MRD detection, in the second part I developed a strategy to co-detect ctDNA along with circulating tumor RNA (ctRNA). An advantage of ctRNA is its active release into the circulation from living cancer cells. Preliminary data showed that more mutant molecules were identified after incorporating ctRNA with ctDNA detection in a metastatic breast cancer setting. A validation study in early-stage TNBC is in progress. In summary, my study suggests that co-detection of ctDNA and ctRNA could be a potential solution for the early detection of disease recurrence.
2021-08-05
Chen, Yi-Chun, and 陳儀君. "Generation of a zebrafish xenograft model of triple-negative breast cancer for evaluating the therapeutic efficacy of Tilapia piscidin 4 (TP4)." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/88652006096495512283.
臺灣大學
漁業科學研究所
103
Among the breast cancer subtypes, triple negative breast cancer (TNBC) (ER/PR/HER2) is particularly challenging and difficult-to-treat. Combinations of surgery, hormone, irradiation, and targeted therapies are not usually effective to TNBC patients but chemotherapy was shown good therapeutic efficacy. However, failure in TNBCs treatment by chemotherapy is the cause of multidrug-resistant (MDR) cancer cell developed and healthy cells are disrupted, causing adverse side-effects. Therefore, identifying the molecular targets underlying chemotherapy could contribute to the development of novel cytotoxic agents as well as the improvement of TNBC killing selectivity. Cationic antimicrobial peptides (CAPs) are cytotoxic to certain cancer types, but are less toxic to normal cells. Nile Tilapia piscidin 4 (TP4) is a CAP derived from Nile tilapia (Oreochromis niloticus). Synthetic TP4 was shown to inhibit gram-positive/negative bacteria; however, its role in BC toxicity has not been investigated. In this study, three BC cell lines were used for evaluating the therapeutic efficacy of TP4 in vitro. Transcriptome study was carried out to explore the potential therapeutic factors induced by TP4 in TNBC cell. In addition, zebrafish xenograft model was developed to investigate the therapeutic efficacy of TP4 in vivo. Cell viability assay showed that synthetic TP4 selectively damages to BC cells (MDA-MB-231/MDA-MB-453/MCF-7) but is less toxic to normal cells (M10/HDF). Microarray study identified FOS family proteins were affected by TP4 treatment in TNBC cells and that overexpression of a FOS family protein, FOSB, caused dramatically TNBC cell death. In addition, we observed TNBC xenotransplantation caused significant zebrafish death in vivo; however, TP4 prolongs the survival in TNBC xenograft zebrafish under a safe dosage. In this study, we confirmed that synthetic TP4 shows selective cytotoxicity to TNBC cell and good therapeutic efficacy. We also identified FOSB as a probable prognostic factor among effective TNBC treatment.
劉家銘. "Online Generation of Association Rules by Negative Correlation." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/82169915037430124598.
Weng, Chiao-Ling, and 翁巧苓. "The Study on Generation Method of Environmental Negative Air Ions." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/35686423700688946572.
國立臺灣大學
環境工程學研究所
93
According to many research reports, the air ions in the atmosphere would affect the health of the human body. The concentration of air ions can reflect the degree of the air pollution directly in the present environment. The relative literatures indicate that the negative air ions (NAIs) have the positive effect on the human health. The in-situ monitor of air ion concentrations in the urban area is performed in this study. The concentrations of the positive and negative air ions in the fountain area are analyzed to obtain the relative information. On the other hand, the NAIs are generated from the mechanism of the breakup of water droplets by the lab atomizer in this study. The relationship between the concentration of NAIs and the operating condition is investigated. There are four monitoring sites for the measurement of background air ions in the fountain-containing area, including the first floor of Taipei County Government building, the open space of Yungho Jen-AI park, the back door of Taipei Metro Mall, and the cross section of Song-Shou and Keelung Roads. The average concentration of NAIs in these background sites is between 641 and 1131 ions/cm3. The concentration of the positive air ions (PAIs) is greater than that of NAIs with the concentration ratio of PAIs/NAIs of 1.1 in the traffic region due to the heavy vehicle transportation and human activities. However, the concentration of NAIs is higher than that of PAIs in the open space of Yungho Jen-AI park due to less air pollution sources. The concentration of NAIs is about 3.7 times that of PAIs with the concentration ratio of PAIs/NAIs of 0.27. The four sampling points of the fountain scenes includes the indoor waterfall in the building of Taipei County Government, the outdoor waterfall in Yungho Jen-AI park, the fountain in front of Taipei Metro Mall, and the fountain near the cross section of Xinyi and Keelung Roads. The average concentration of NAIs around the fountain scenes is between 38,320 ~ 263,863 ions/cm3. Among all, the concentration of NAIs near the fountain in front of Taipei Metro Mall is highest. The atomization system is employed to simulate the generation of NAIs by the breakup of water droplets in the laboratory. There are two atomized water sources and three different pressures. The results show that the concentration of NAIs is higher when the water source is clearer. The NAIs generated from the atomization of pure water is about 3.4 ~ 16.4 times that of tap water. The concentration of NAIs increases with the pressure of atomization. For example, the concentration of NAIs generated at the atomization pressure of 30 PSI is higher as 3.6 to 8.7 times that of 20 PSI.
Lin, Chin-Chieh, and 林瑾杰. "Effect of Carbon-Nanotubes Mass on the Generation of Negative Air Ions." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/76058877874917099843.
Cumbo, Chiara, Pasquale Rullo, and Annamaria Canino. "A techinique for automatic generation of rule-based text classifiers exploiting negative information." Thesis, 2014. http://hdl.handle.net/10955/499.
Hsu, Meng-Tsung, and 徐孟琮. "The traits of carbon-nanotubes affect generation of negative air ions by electric discharging." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/64157284559370434726.
國立臺灣大學
環境工程學研究所
96
This study investigated the traits of carbon-nanotubes (CNTs) affect generation of negative air ions (NAIs) by negative electric discharging, and investigated the feasibility of developing a microscale air cleaner. The research investigated the effect of the discharging voltage about CNTs on the one and two dimension metal substrate, the aspect ratio of CNTs, aligned CNTs, single-walled and multi-walled CNTs, metal material, metal aspect ratio, metal needle-point curvature, the stability and the effective distance of NAIs which were generated by negative electric discharging, dectecting ozone concentration. Because electrons can gather on need-point of one dimension substrate to make electrons excite easilier, the discharging voltage of CNTs on the one dimension metal substrate gets lower than other on the two dimension metal substrate. The enhanced field emission gets bigger and the discharging voltage gets lower when the aspect ratio of CNTs gets bigger. Beacause CNTs array align regularly, it can reduce screening effect and the discharging voltage effectively. Because of bigger aspect ratio and better conductivity the discharging voltage of Single-walled CNTs gets lower than the one of multi-walled CNTs. At the same discharging voltage, the stability of NAIs which were generated by negative electric discharging gets better when the aspect ratio of CNTs gets bigger. The NAIs concentration decreased when the distance increased, and The NAIs concentration and the distance indicated logarithmic linear relationship. The NAIs concentration of CNTs on copper and silver electrode which was used as the negative electrode to generate NAIs can reach detecting limit range when the discharging voltage was about 1.6 kV and 1.4 kV, and there was no generation of ozone. When the discharging voltage was about 3.0 kV, ozone concentration which was generated by CNTs on copper and silver electrode was about 0.5 ppb and 0.6 ppb, and ozone concentration increased fast when the discharging voltage increased.
Liao, Gong-Pu, and 廖弓普. "Development of Microscale Air Ionizer -- Generation of Negative air Ions by Carbon-nanotube Electric Discharging." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/75637050061553359015.
國立臺灣大學
環境工程學研究所
95
This study investigated the operational factor and the base property of the negative air ions (NAIs) which were generated by negative electric discharge. This study also investigated the characteristics of carbon nanotubes which was used to generate negative air ions to develop a microscale air cleaner (MAC). First, this research investigated the influence of the initial discharging voltage about needle-point curvature, electrode diameter, electrode material, and the characteristics of carbon nanotubes. Second, it studied the effective distance of NAIs, stability of NAIs generator. NAIs were generated by the negative electric discharge method. The results show that the initial discharging voltage gets lower when the electrode needle-point curvature gets bigger. At the same needle-point curvature, the initial discharging voltage is lower when the electrode diameter is shorter. For different electrode material, when needle-point curvature and diameter are constant, copper had the lowest initial discharging voltage and followed by silver, graphite, lead, iron, tungsten, aluminum. The initial discharging voltage of carbon nanotubes which was used as the negative electrode to generate NAIs can be under 0.2 kV that was much lower than the initial discharging voltage of the experimental metal electrode. At relative humidity 40%, ozone was generated at 0.5 ppb when NAI concentration was about 6.3*105 ion/cm3. At relative humidity 70%, ozone was generated at 0.5 ppb when NAI concentration was about 9*105 ion/cm3. The NAI concentration decreased with the distance. The regression analysis of NAI concentration and distances from the discharge electrode indicated a logarithmic linear relationship. Additionally, more stable NAIs were generated by carbon nanotubes than other by metal electrodes when voltage was increased.
Tzeng, Xian-Yau, and 曾顯堯. "Generation Negative Air Ions by Carbon Nanotube Directly Grown on Carbon Cloth by Chemical Vapor Deposition." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/55285148954345519264.
國立臺灣大學
環境工程學研究所
102
The purpose of this study is to produce a portable negative air ion (NAI) generator. NAI generated by corona discharge. In order to be portable, voltage which produces air ions needed should be reduced. This study attempts to replace the different electrode to reduce the voltage required to produce NAI. In this study chose carbon nanotubes directly (CNTs) grown on carbon cloth as the discharge electrode. It has lower resistance than the CNTs stick to the substrate. In this study, CNT have six terms, they are doped nitrogen (CNT-N) or not (CNT), growing time that is 5min, 10min, 15min. In this study measures starting voltage, stability of discharging and steady concentration of NAI in RH=0%, 20%, 40%, 60%, 80%,. The result of experiment reveal CNT-N is easier gathering than CNT. Growing time of CNT in 5min, 10min, 15min that their starting voltage is 2.3kV、1.93kV、2.06kV; Growing time of CNT-N in 5min, 10min, 15min that their starting voltage is 3.23 kV、1.86 kV、2.33 kV. It revels CNT have lower staring voltage in 5min and 15min. CNT-N in 10min have lower starting voltage. Measuring six different CNTs in relative humidity is 0%, 20%, 40%, 60%, 80%, the average value of starting voltage is 2.22±0.43kV、1.67±0.38kV、1.63±0.38kV、1.63±0.36kV、1.67±0.37kV, showing in 20%~60% has lower starting voltage. Testing in stability with humidity 40% and 2.5kV, growing time of CNTs-blank in 5min, 10min, 15min their coefficient of variation is 5.50%、64.98%、10.75%, growing time of CNT-N 5min, 10min, 15min their coefficient of variation is 20.78%、63.26%、8.84%, they reveal growing in 5min and 15min have better stability. Four electrode with higher stability : growing time of CNTs-N in 5min, 15min and growing time of CNTs-blank in 5min, 15min. Chose the steady concentration of NAI is higher than 200×103ions/cm3 and growing time of CNT in 15min (CNT-15) which starting voltage is the lowest electrode as the best electrode. Observing the relation of distance, humidity and concentration of NAI which generated by CNT-15. The result reveal when the longer distance between detector and generator the lower concentration of NAI. And continuous discharging electricity in 30 min, detecting concentration of ozone is 1.5ppb、2.1ppb、0.8ppb、1.8ppb、2.4ppb、1.6ppb, lower 0.06ppm in air quality law, in the course, producing ozone is not enough to endanger human body. Starting voltage of CNT-15 between 1.9~2.0kV. Coefficient of variation is 10.75%, average of concentration of NAI is around 773×103ions/cm3 , while CNT-15 discharge at -2.5kV and R.H.=40%. CNT 15 is most suitable CNTs to producing NAI in this study. Compare CNT-15 with research of 林(2009) stick carbon nanotubes on iron substrate (Fe-CNT), Fe-CNT has lower starting voltage(0.5kV). Fe-CNT can produce NAI only for 3 min. Consider the produce time of NAI, CNT-15 is better than Fe-CNT.
Lu, Shan-Jen, and 盧宣任. "The effect of field emission traits of carbon-nanotubes on the generation of negative air ions." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/38403545768069636163.
國立臺灣大學
環境工程學研究所
97
This study investigated the traits of field emission effect of carbon-nanotubes (CNTs) on generation of negative air ions (NAIs) by negative electric discharging, and the feasibility of developing a microscale air cleaner. The research evaluated the effect of the aspect ratio of CNTs, density of the CNTs, single-wall and multi-wall CNTs and double-wall CNTs, metal material, metal aspect ratio, and metal needle-point curvature on the discharging voltage of CNTs. It also evaluated the stability and the effective space of the generation of NAIs by using CNTs with negative electric discharging, and studied the possible generation of ozone. The results show that enhanced field emission gets bigger when the aspect ratio of CNTs increased, so that discharging voltage gets lower. The limited voltage value of multi-wall CNTs(aspect ratio ranged from 1666.66 to 5000) required only 0.5 kV when they used as discharging electrode. That was the first time the value lower than 1.0 kV. CNTs array can reduce screening effect because of regular alignment and also reduce discharging voltage effectively. The field emission from CNTs array could be optimized with the inter-tube distance of 10th of the height(CNTs array with density of 1~2×109 CNTs/cm2). No matter the number of layers of CNTs, the CNTs with greater aspect ratio have lower discharging voltage. At same discharging voltage, the stability of NAIs by negative electric discharging gets higher when the aspect ratio of CNTs increases. And we find out that the stability of generate NAIs by imitate pulsed corona is much better than continued discharging. If we close the electric field for 30sec and restart it for 1 minutes. We could keep the concentration of NAIs over than 4.0×105ions/cm3 for 30minutes. The NAIs concentration did not change with increasing space. CNTs on copper electrode can reach detecting limit range of NAIs at discharging voltage of 0.5kV without generation of ozone. At discharging voltage of 2.5 kV, CNTs on copper electrode begin to generate ozone at 0.2 ppb, this value is much lower than the Indoor Air Quality value (0.03 ppm), so we don’t have to worry about the problem of ozone pollution.
Kjellberg, Marcus, and Barry Spaan. "Sustainability advertisements : The effects of negative and positive appeals on generation Y’s attitudes towards sustainable concerns." Thesis, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-73036.
Chen, Yi Liu, and 劉辰宜. "Candidates’ Appearance Attractiveness, Gender, and Positive/Negative Appeals on the Political Advertising Attitude:A Case of Young Generation." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/w45eb6.
輔仁大學
企業管理學系管理學碩士班
103
The purpose of this study is to discuss the impacts under candidates’ appearance attractiveness (high attractiveness / low attractiveness), candidates’ gender (male/ female) and political advertising (positive appeals /negative appeals) on the advertising effectiveness. A total of 234 respondents participated in this study. An experimental method was used in this study, and data were analyzed by performing 3-way ANOVA. There are some findings in this study:(1) High attractiveness candidates have better advertising attitude than low attractiveness candidates;(2) Positive appeals advertisements have better advertising attitude than negative appeals advertisements;(3) High attractiveness candidates use negative appeals advertisements have better advertising attitude than low attractiveness candidates use negative appeals advertisements.
Seymore, Reyno. "The competitiveness effects of electricity generation taxes : a computable general equilibrium analysis." Thesis, 2011. http://hdl.handle.net/2263/28732.
Thesis (DCom)--University of Pretoria, 2011.
Economics
unrestricted
Kan, Li-Hsing, and 甘力行. "High energy pulse generation in large negative-dispersion mode-locked Er-doped fiber laser with long cavity length." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/63481228711128143870.
國立交通大學
顯示科技研究所
99
In this thesis, we experimentally demonstrate a passive mode-locked Erbium-doped fiber laser with large net round trip anomalous dispersion and nonlinearity through about 400m cavity length. The laser can output optical pulse trains at the low repetition rate around 500kHz and with the high pulse energy larger than 120nJ directly from the laser output. By adjusting the polarization controllers (PCs) and the pump power level, high energy pulses with square profile and nanosecond pulse-width without pulse breaking can be observed. Finally, we study the characteristic parameters of our pulses for further compressing the pulse-width to attain the short pulse-width and high peak power.
Neill, Joanna C., Samuel Barnes, Samantha Cook, Ben Grayson, Nagi F. Idris, Samantha L. McLean, S. Snigdha, Lakshmi Rajagopal, and Michael K. Harte. "Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism." 2010. http://hdl.handle.net/10454/8461.
Cognitive deficits in schizophrenia remain an unmet clinical need. Improved understanding of the neuro- and psychopathology of these deficits depends on the availability of carefully validated animal models which will assist the development of novel therapies. There is much evidence that at least some of the pathology and symptomatology (particularly cognitive and negative symptoms) of schizophrenia results from a dysfunction of the glutamatergic system which may be modelled in animals through the use of NMDA receptor antagonists. The current review examines the validity of this model in rodents. We review the ability of acute and sub-chronic treatment with three non-competitive NMDA antagonists; phencyclidine (PCP), ketamine and MK801 (dizocilpine) to produce cognitive deficits of relevance to schizophrenia in rodents and their subsequent reversal by first- and second-generation antipsychotic drugs. Effects of NMDA receptor antagonists on the performance of rodents in behavioural tests assessing the various domains of cognition and negative symptoms are examined: novel object recognition for visual memory, reversal learning and attentional set shifting for problem solving and reasoning, 5-Choice Serial Reaction Time for attention and speed of processing; in addition to effects on social behaviour and neuropathology. The evidence strongly supports the use of NMDA receptor antagonists to model cognitive deficit and negative symptoms of schizophrenia as well as certain pathological disturbances seen in the illness. This will facilitate the evaluation of much-needed novel pharmacological agents for improved therapy of cognitive deficits and negative symptoms in schizophrenia.
JHANG, JING-YU, and 張競宇. "The Influence of Negative Electronic Word-of-Mouth on Consumer Switching Behavior : Take Next-Generation Video Game Consoles for Example." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/yd9vfe.
國立臺灣科技大學
企業管理系
95
This research is to investigate electronic negative word-of-mouth and the influence on consumer switching behavior. Electronic negative word-of-mouth is that through web-based consumer opinion platforms, customers can share their opinions on, and dissatisfied experiences with, goods or services with a multitude of other consumers and suggest others not to purchase this goods or services. This research is to discuss the impact of the strength of electronic negative word-of-mouth, the disseminator’s expertise and the strength of relationship on consumer switching behavior, and this study also discusses how swatching cost play as a moderator on the negative effect. On the research approach, this research regards internet network user as the research object, and choose the next-generation video game consoles to fill out and answer the products as the questionnaire. The analysis used hierarchical regression analysis to analyze variables influence on consumer switching behavior in the model. The results reveal that the strength of electronic negative word-of-mouth, the disseminator’s expertise and the strength of relationship would affect the consumer switching behavior. Swatching cost will weaken the strength of relationship impact on consumer switching behavior.
Hansen, Kristy Lee. "Effect of leading edge tubercles on airfoil performance." Thesis, 2012. http://hdl.handle.net/2440/79211.
Thesis (Ph.D.) -- University of Adelaide, School of Mechanical Engineering, 2012
Comeau, Kathryn Marie. "Generation of both an shRNA-resistant MEF2A over expression construct and a dominant negative construct in adenovirus for rescue and knockout experiments in muscle." Thesis, 2015. https://hdl.handle.net/2144/14021.
Venkataraman, Anusha. "Self-assembled nanoelectronic networks with tunable molecule-nanoparticle ratios: experiment, modeling, and applications." Thesis, 2021. http://hdl.handle.net/1828/13442.
Graduate
Alibakhshikenari, M., B. S. Virdee, L. Azpilicueta, M. Naser-Moghadasi, M. O. Akinsolu, C. H. See, B. Liu, et al. "A comprehensive survey of "metamaterial transmission-line based antennas: design, challenges, and applications"." 2020. http://hdl.handle.net/10454/18129.
In this review paper, a comprehensive study on the concept, theory, and applications of composite right/left-handed transmission lines (CRLH-TLs) by considering their use in antenna system designs have been provided. It is shown that CRLH-TLs with negative permittivity (ε <; 0) and negative permeability (μ <; 0) have unique properties that do not occur naturally. Therefore, they are referred to as artificial structures called “metamaterials”. These artificial structures include series left-handed (LH) capacitances (C L ), shunt LH inductances (L L ), series right-handed (RH) inductances (LR), and shunt RH capacitances (CR) that are realized by slots or interdigital capacitors, stubs or via-holes, unwanted current flowing on the surface, and gap distance between the surface and ground-plane, respectively. In the most cases, it is also shown that structures based on CRLH metamaterial-TLs are superior than their conventional alternatives, since they have smaller dimensions, lower-profile, wider bandwidth, better radiation patterns, higher gain and efficiency, which make them easier and more cost-effective to manufacture and mass produce. Hence, a broad range of metamaterial-based design possibilities are introduced to highlight the improvement of the performance parameters that are rare and not often discussed in available literature. Therefore, this survey provides a wide overview of key early-stage concepts of metematerial-based designs as a thorough reference for specialist antennas and microwave circuits designers. To analyze the critical features of metamaterial theory and concept, several examples are used. Comparisons on the basis of physical size, bandwidth, materials, gain, efficiency, and radiation patterns are made for all the examples that are based on CRLH metamaterialTLs. As revealed in all the metematerial design examples, foot-print area decrement is an important issue of study that have a strong impact for the enlargement of the next generation wireless communication systems.
This work was supported in part by the Ministerio de Ciencia, Innovación y Universidades, Gobierno de España (MCIU/AEI/FEDER, UE) under Grant RTI2018-095499-B-C31, in part by the Innovation Programme under Grant H2020-MSCA-ITN-2016 SECRET-722424, and in part by the financial support from the U.K. Engineering and Physical Sciences Research Council (EPSRC) under Grant EP/E022936/1.