Dissertations / Theses on the topic 'Genealogy'
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1
Colatosti, Jennifer M. "Genealogy." Ohio : Ohio University, 2008. http://www.ohiolink.edu/etd/view.cgi?ohiou1213029447.
2
Frazier, Richard A. "Genealogy research, Internet research and genealogy tourism." Online version, 2001. http://www.uwstout.edu/lib/thesis/2001/2001frazierr.pdf.
3
Riester, Markus. "Genealogy Reconstruction." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-38656.
Abstract:
Genealogy reconstruction is widely used in biology when relationships among entities are studied. Phylogenies, or evolutionary trees, show the differences between species. They are of profound importance because they help to obtain better understandings of evolutionary processes. Pedigrees, or family trees, on the other hand visualize the relatedness between individuals in a population. The reconstruction of pedigrees and the inference of parentage in general is now a cornerstone in molecular ecology. Applications include the direct infer- ence of gene flow, estimation of the effective population size and parameters describing the population’s mating behaviour such as rates of inbreeding.
In the first part of this thesis, we construct genealogies of various types of cancer. Histopatho- logical classification of human tumors relies in part on the degree of differentiation of the tumor sample. To date, there is no objective systematic method to categorize tumor subtypes by maturation. We introduce a novel algorithm to rank tumor subtypes according to the dis- similarity of their gene expression from that of stem cells and fully differentiated tissue, and thereby construct a phylogenetic tree of cancer. We validate our methodology with expression data of leukemia and liposarcoma subtypes and then apply it to a broader group of sarcomas and of breast cancer subtypes. This ranking of tumor subtypes resulting from the application of our methodology allows the identification of genes correlated with differentiation and may help to identify novel therapeutic targets. Our algorithm represents the first phylogeny-based tool to analyze the differentiation status of human tumors.
In contrast to asexually reproducing cancer cell populations, pedigrees of sexually reproduc- ing populations cannot be represented by phylogenetic trees. Pedigrees are directed acyclic graphs (DAGs) and therefore resemble more phylogenetic networks where reticulate events are indicated by vertices with two incoming arcs. We present a software package for pedigree reconstruction in natural populations using co-dominant genomic markers such as microsatel- lites and single nucleotide polymorphism (SNPs) in the second part of the thesis. If available, the algorithm makes use of prior information such as known relationships (sub-pedigrees) or the age and sex of individuals. Statistical confidence is estimated by Markov chain Monte Carlo (MCMC) sampling. The accuracy of the algorithm is demonstrated for simulated data as well as an empirical data set with known pedigree. The parentage inference is robust even in the presence of genotyping errors. We further demonstrate the accuracy of the algorithm on simulated clonal populations. We show that the joint estimation of parameters of inter- est such as the rate of self-fertilization or clonality is possible with high accuracy even with marker panels of moderate power. Classical methods can only assign a very limited number of statistically significant parentages in this case and would therefore fail. The method is implemented in a fast and easy to use open source software that scales to large datasets with many thousand individuals.
4
Ozmetin, Yeliz. "Genealogy Of." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12610086/index.pdf.
Abstract:
&ldquoPlace&rdquo
is a complex and contested term being exposed to various theorizations and positions in diverse fields. Aiming to get an understanding of what it may contribute to in the discourse of architecture, the thesis firstly offers a framework that helps to depict a genealogy of &ldquo
place&rdquo
through its itinerary in phenomenologically driven human geography where it originated as a conceptual term, and in architecture to which became an important issue of debate and theorization over the relation between building activity and the ground. Conveying an understanding of &ldquo
place&rdquo
as an ethical component in architecture&rsquo
s agenda, the thesis defines architecture as the &ldquo
identification of place&rdquo
, and comes up with ideas for a conceptual framework of &ldquo
gathering&rdquo
insight concerning the physical location/condition, namely &ldquo
place&rdquo
, through the study and understanding of its components, namely &ldquo
reading&rdquo
them. The significance of defining, listening to and interpreting physical location/condition for a more &ldquo
enriched mission of architecture&rdquo
within developing a notion of dialogue is addressed in this thesis.
5
Berthold, Dana M. "A genealogy of purity /." view abstract or download file of text, 2005. http://wwwlib.umi.com/cr/uoregon/fullcit?p3181084.
Abstract:
Thesis (Ph. D.)--University of Oregon, 2005.Typescript. Includes vita and abstract. Includes bibliographical references (leaves 157-166). Also available for download via the World Wide Web; free to University of Oregon users.
6
Galbraith, D. "A genealogy of law." Thesis, University of Edinburgh, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234064.
7
Wisely, Colin David. "Genealogy of the needle." Thesis, Manchester Metropolitan University, 2014. http://e-space.mmu.ac.uk/332938/.
Abstract:
The Foucault influenced Opium and the People (1981) has generated considerable interest in its dealing with the construction of the medico-legal persona of the addict and has come to dominate many different interdisciplinary areas of study. An important critique of this work can be found in Henry Bryan Spear’s response to criticisms of civil servant Sir Malcolm Delevigne. These points reveal the operation of the repressive hypothesis in drugs discourse. The limitations of Opium and the People call for a fuller genealogical analysis of the subject of addiction. Discipline and Punish (1991a) and History of Sexuality Part One (1998) are the publications closely associated with the genealogical period of Foucault’s thought. The earlier publication of History of Madness (2006a) and Foucault’s lecture series also enable further interesting insights into the hermeneutics of addiction. One minor area for Opium and the People is the emergence of injection drug use and this phenomenon represents the focus of this thesis. It is through the story of the hypodermic syringe that we can see with more detail how the hermeneutic processes that were intended to eradicate opium use for pleasure ultimately led to the spread of intravenous injection. Beginning with the structural elision of the pain controlling from the pleasure producing elements of opium we can see the unexpected consequences of utopianism in the form of an outbreak of intravenous knowledge in the 1920s New York City following the imposition of a total prohibition on opiates. Through the tale of the hypodermic we can see the creation of the modern day ‘Tom Thumb horror’, the influence of confessional technology and the importance of resistance to bio-technico power in the creation of the phenomenon of intravenous injection drug use. In Part One: ‘Self and Truths’ I outline the methodological project, the role of Friedrich Nietzsche’s thought upon Foucault’s idea of history. Here we will establish the core elements of Foucault’s genealogical method with a specific emphasis on the importance of the repressive hypothesis as outlined in The History of Sexuality Part One (1998) for the creation of the pejorative archetype of the junkie. In Part Two: ‘Structure, Monsters and Poets’ the importance of Descartes’ thought on the experimental enquiry into the control of pain are considered along with the inability to include the euphoria that opium induces. The importance of the History of Madness (2006a) is developed in this section as a key problem in our comprehension of the prohibitive response to the pleasures that are associated with opium. This section considers the importance of juridical process in the creation of the ‘Tom Thumb horror’, a process whereby legal case law is linked to broader medical and legal processes, thus enabling the creation of medico-legal persona that are related to specific jurisprudence. The importance of the creation of the idea of inebriety and the link developed between opium and alcohol enables us to observe this ongoing process. I consider the role of Thomas DeQuincey and Samuel Taylor Coleridge in the creation of the opium eater and the mysterious process whereby these musings became established as legal and medical facts. The significance of DeQuincey’s Stoic method of introspection and its impact on the creation of a new medical condition is developed. In Part Three: ‘The Needle, Inebriety and Resistance’, I explore the invention of the hypodermic and its spread across the globe. I look at the ongoing legal process that led to the abolition and the creation of an industry around a new medico-legal identity of the opium eater. The decline of the opium trade and the eventual prohibition are set against a paradoxical response of a small proportion of opium users that provides clear empirical evidence of a phenomenon that Foucault termed resistance. The importance of the relationship between hermeneutics, public policy and resistance in the creation of the conditions that led to the spread of the knowledge of intravenous injection forms the basis of the main conclusion of this study. In the final section I explore the implications of this study in the present-day and consider a Cynic alternative to the Stoic view of opium addiction.
8
McGillivray, Glen. "Theatricality a critical genealogy /." Connect to full text, 2004. http://hdl.handle.net/2123/1428.
Abstract:
Thesis (Ph. D.)--University of Sydney, 2004.Title from title screen (viewed 25 March 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Dept. of Performance Studies, Faculty of Arts. Includes bibliographical references. Also available in print form.
9
Bartelson, Jens. "A genealogy of sovereignty /." Stockholm : University of Stockholm, 1993. http://catalogue.bnf.fr/ark:/12148/cb35723554q.
10
McGillivray, Glen James. "Theatricality: A critical genealogy." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/1428.
Abstract:
ABSTRACT The notion of theatricality has, in recent years, emerged as a key term in the fields of Theatre and Performance Studies. Unlike most writings dealing with theatricality, this thesis presents theatricality as a rubric for a particular discourse. Beginning with a case-study of a theatre review, I read an anti-theatricalist bias in the writer’s genre distinctions of “theatre” and “performance”. I do not, however, test the truth of these claims; rather, by deploying Foucauldian discourse analysis, I interpret the review as a “statement” and analyse how the reviewer activates notions of “theatricality” and “performance” as objects created by an already existing discourse. Following this introduction, the body of thesis is divided into two parts. The first, “Mapping the Discursive Field”, begins by surveying a body of literature in which a struggle for interpretive dominance between contesting stakeholders in the fields of Theatre and Performance Studies is fought. Using Samuel Weber’s reframing of Derrida’s analysis of interpretation of interpretation, in Chapter 2, I argue that the discourse of the field is marked by the struggle between “nostalgic” and “affirmative” interpretation, and that in the discourse that emerges, certain inconsistencies arise. The disciplines of Theatre, and later, Performance Studies in the twentieth century are characterised, as Alan Woods (1989) notes, by a fetishisation of avant-gardist practices. It is not surprising, therefore, that the values and concerns of the avant-garde emerge in the discourse of Theatre and Performance Studies. In Chapter 3, I analyse how key avant-gardist themes—theatricality as “essence”, loss of faith in language and a valorisation of corporeality, theatricality as personally and politically emancipatory—are themselves imbricated in the wider discourse of modernism. In Chapter 4, I discuss the single English-language book, published to date, which critically engages with theatricality as a concept: Elizabeth Burns’s Theatricality: A Study of Convention in the Theatre and Social Life (1972). As I have demonstrated with my analysis of the discursive field and genealogy of avant-gardist thematics, I argue that implicit theories of theatricality inform contemporary discourses; theories that, in fact, deny this genealogy. Approaching her topic through the two instruments of sociology and theatre history, Burns explores how social and theatrical conventions of behaviour, and the interpretations of that behaviour, interact. Burns’s key insight is that theatricality is a spectator operation: it depends upon a spectator, who is both culturally competent to interpret and who chooses to do so, thereby deciding (or not) that something in the world is like something in the theatre. Part Two, “The Heritage of Theatricality”, delves further, chronologically, into the genealogy of the term. This part explores Burns’s association of theatricality with an idea of theatre by paraphrasing a question asked by Joseph Roach (after Foucault): what did people in the sixteenth century mean by “theatre” if it did not exist as we define today? This question threads through Chapters 5 to 7 which each explore various interpretations of theatricality not necessarily related to the art form understood by us as theatre. I begin by examining the genealogy of the theatrical metaphor, a key trope of the Renaissance, and one that has been consistently invoked in a range of circumstances ever since. In Chapter 5 explore the structural and thematic elements of the theatrical metaphor, including its foundations, primarily, in Stoic and Satiric philosophies, and this provides the ground for the final two chapters. In Chapter 6 I examine certain aspects of Renaissance theories of the self and how these, then, related to public magnificence—the spectacular stagings of royal and civic power that reached new heights during the Renaissance. Finally, in Chapter 7, I show how the paradigm shift from a medieval sense of being to a modern sense of being, captured through the metaphor of a world view, manifested in a theatricalised epistemology that emphasised a relationship between knowing and seeing. The human spectator thus came to occupy the dual positions of being on the stage of the world and, through his or her spectatorship, making the world a stage.
11
Fetterolf, Elianna. "Remorse : a prospective genealogy." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/9981/.
Abstract:
Although moral philosophy has seen an upsurge of work in moral emotions, remorse is significantly neglected. Part of what explains the neglect, I argue, is a commitment to a narrow, ultimately distorted, conception of remorse. Central to my line of argument is the idea that what makes remorse distinctively moral is its special focus with those directly affected by what one has done. Foregrounding this claim, however, reveals the narrow conception to be detached from what is widely taken to ground it. If we preserve the special moral character of remorse two controversial conclusions follow: (i) that the scope of remorse is broader than standardly taken to be, and, (ii) that the ubiquitous assumption that remorse is merely the first-personal mirror of justified blame comes into problematic doubt. New lines of debate concerning the adequacy of the narrow conception as well as key objections against moral theories committed to it are opened.
12
Tolley, Rebecca. "Genealogy, March of Dimes." Digital Commons @ East Tennessee State University, 2002. https://www.amzn.com/0684805332.
Abstract:
Book Summary: The third edition of this classic and indispensable work, first published in 1940 and last revised in 1976, has been updated completely for a new generation of students and scholars. Recognizing that the ways in which history is understood and interpreted have changed drastically over the past six decades, the editors have revised 448 articles, replaced 1,360 articles, and added 841 new entries. Gender, race, and social-history perspectives have been added to many entries for the first time. In another departure from the earlier editions, the editors have added maps and illustrations throughout the text, providing helpful visual cues to readers. No library should be without these new volumes."--"The Best of the Best Reference Sources," American Libraries, May 2003.Collects articles, illustrations and photographs, and maps pertaining to notable events in American history.
13
Caron, Caroline-Isabelle. "Se creer des ancetres. : les ecrits historiques et genealogiques des de Forest et des Forest d'Amerique du Nord, 19e et 20e siecles." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36886.
Abstract:
This thesis examines the exercise of genealogy in North America in the 19th and 20th centuries through an analysis of the historical and genealogical writings by and about the (real and presumed) descendants of two Walloon brothers, Jesse (c 1580--1624) and Gerard de Forest (1583--1654). It also follows genealogy's slow democratization, from its late 19th century bourgeois users to the explosion of its popularity since 1977. A thorough theoretical base was needed to compensate for the absence of historical studies on the subject. The thesis then follows the construction over the course of 140 years of the de Forest and Forest historical narrative, through the successive publications of various versions of this story, fundamentally one of identity. From research project to research project, these genealogists were influenced by the time period, the social, cultural, and commemorative settings in which they wrote, in New England, New York, Acadia, Quebec, Louisiana, and Ontario. Their research techniques, their processes for acquiring and exchanging knowledge, and the manner in which they wrote their narratives, revealed their aspirations, their self-representations, those of their families and their ancestors, as well as their gender, class, and ethnicity. Their ancestor biographies showed a desire to make public the true history of their ancestors, for their family's glory, whether or not their ancestry was real or invented. In the hope of unifying the family, boaster the popularity of a famous ancestor or of an interest group, these genealogists constructed histories based on oral traditions, primary sources, and in response to the works of their predecessors. Through the years, the material conditions of genealogical research and publication changed greatly, particularly with the advent of computing, but the most important influences on genealogy writing have been the feminisation of genealogists, the multiplication of descendants willing to write, and the chao
14
Buonamano, Roberto Law Faculty of Law UNSW. "A genealogy of subjective rights." Awarded by:University of New South Wales. School of Law, 2006. http://handle.unsw.edu.au/1959.4/31948.
Abstract:
This dissertation is an historical and philosophical study on the development of a subjective concept of individual rights. It takes the form of a history of ideas informed by genealogical methods of inquiry. Rather than seeking an origin for and underlying truth to human rights, it treats human rights as a product of various historical developments which are capable of being investigated in terms of their contingency as well as their continuous traditions. The thesis begins with an analysis of political theory in ancient Greek thought, primarily as a means of suggesting possible alternative political philosophies to the rights-based approach dominant in modern Western societies. The thesis then considers the theologicalpolitical discourse on sovereignty in the early Middle Ages, revolving around the doctrine of divine right and influenced by the function of the Christian Church in defining the nature of government. This is followed by an examination of the emergence of hierarchical, feudal relations and the formulation of feudal rights as based on proprietary notions and coinciding with individual liberties. In the following chapter there is a discussion of the juridical construction of sovereign power that emerged from the reception of Roman law and the development of canon law, the influence of legal textuality on the granting of rights and liberties, and the emergence of a discourse on public right as a way of defining the relationship between the prince and his subjects and thus delimiting sovereign authority. Finally, the thesis considers the legacy of the theory of natural rights and its relationship to forms of liberty, with an analysis of: firstly, the idea of natural rights that developed through canon law and the discussions surrounding the Franciscan poverty disputes; secondly, the role of property rights in the formulation of the rights of liberty; thirdly, the Christian understanding of liberty as a subjective attribute or power through the theo-ontological theory of human nature as represented by the free will; and fourthly, the transformation in Renaissance and early modern legal and political theory of the concept of liberty into a political doctrine about individual autonomy and inherent freedom. The purpose of the dissertation is to describe the multiple and complex historical processes from which the idea of subjective rights has emerged, as a means of understanding how human rights have come to play a seemingly essential role in modern legal and political discourses and practices.
15
Douglas, Ian. "On the genealogy of globalism." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398702.
16
MATTOS, ANITA TANDETA. "NIETZSCHENULLS GENEALOGY: REASON AND VIOLENCE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2006. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9604@1.
Abstract:
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFUNDAÇÃO DE APOIO À PESQUISA DO ESTADO DO RIO DE JANEIRO
Partindo do lugar reservado à interpretação no método genealógico de Nietzsche, o presente mostra que a genealogia, por ouvir o silêncio inerente às produções culturais, por se ater àquilo que as construções silenciam enquanto são produzidas e preservadas, necessariamente aborda a violência velada por tais empreendimentos. Há um excesso de violência no desenvolvimento da cultura metafísica, proporcional à quantidade existente de mecanismos de encobrimento dessa violência. O esclarecimento genealógico das violências recusadas indica a aposta de Nietzsche no alargamento da razão, cuja direção implica na redução da violência e em novos destinos para o mal-estar sentido pela consciência moral.
Starting with the examination of the place reserved for the interpretation in the Nietzsche´s genealogical method, this work shows that genealogy, by listening the silence inherent to cultural productions, necessarely broaches the violence covered by such undertakings.There is an excess of violence in the development of the metaphysical culture, proportional to the quantity of existing mechanisms for concealing this violence. The revelation of these hidden violences through genealogical method indicated Nietzsche´s bet on the expantion of reason, whose consequences are the reduction of the same violence and the cration of new destinies for the discomfort felt by the moral conciousness.
17
Allsobrook, Christopher John. "'On genealogy and ideology criticism'." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/6319/.
Abstract:
This thesis identifies and explains a fundamental philosophical problem of self-implication in Marxian ideology criticism that has led to its misuse and rejection in social theory and political philosophy. I argue that Friedrich Nietzsche's development of genealogy as a method of social criticism complements ideology criticism in a way that overcomes this problem, by addressing it explicitly, rather than trying to avoid it. In making this argument, I hope to bridge a widely perceived gap between Nietzsche's and Michel Foucault's genealogical approaches to social criticism, on the one hand, and Marxian ideology criticism on the other. The conflict between these approaches has been exaggerated in contemporary academic literature, to the loss of invaluable contributions Nietzsche and Foucault make to the theory and practice of ideology criticism. I begin by defining ideology in way that, I demonstrate, takes into account the use of the notion by Karl Marx and the early Frankfurt School Critical Theorists, Max Horkheimer and Theodor Adorno. I identify two central components of ideology, namely, an epistemic aspect, regarding illusion, and a functional aspect, which links ideology to its role in maintaining oppression. I also defend the notion of ideology against major objections to each of these aspects. In Chapter 4, I introduce the problem of self-implication that, I take it, poses the greatest challenge to the coherence of ideology criticism. The remainder of the thesis examines two alternative ways of dealing with this problem, namely immanent and transcendent criticism. I explain the weaknesses with each approach and, in doing so, show why Marx and Adorno each succumb to the problem of ideological self-implication. In the final chapter I argue that Nietzsche's method of genealogy is compatible with ideology criticism and can complement such criticism, to overcome the problems that have been examined.
18
Ammann, R. K. "Weblogs 1994-2000 : a genealogy." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1399845/.
Abstract:
Using extensive fieldwork in the online archival record, this thesis accounts for the descent and emergence of the weblog as a digital genre during its formative period up to the year 2000. The work examines the weblog’s process of genre formation as diffusion of innovation within a heterogeneous discourse network. It describes this process as a series of several consecutive and cumulative reinterpretations of the emerging genre’s form and intended purpose, effected for the most part by the most central actors in the network.
19
Georgelis, Anna. "Multiperspective visualization of genealogy data." Thesis, Linköpings universitet, Medie- och Informationsteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150535.
Abstract:
This thesis presents and discusses the implementation of a web application developed as a Masters degree project at Linköping University. The application is a tool offering a multiperspective visualization of genealogy data, that can be used by genealogists in order to analyze his or her collected family tree data, but also to find what data that may be wrong. Data stored in a GEDCom file is being processed and stored in a database. By using D3.js, the data is then visualized in three different types of representations: an ancestor tree, a sunburst chart and a lifeline representation, all interacting with each other. The work concludes that by using different types of visualizations to present the same data, it is possible to create a genealogy application where new kind of insights about the data can be gained.
20
Ashcroft, Richard E. "The genealogy of scientific ethics." Thesis, University of Cambridge, 1995. https://www.repository.cam.ac.uk/handle/1810/273029.
21
Sonoda, Milton Taidi. "Dinâmica e genealogia de modelos de evolução." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/76/76131/tde-11112013-104336/.
Abstract:
Nesse trabalho investigamos através de simulações numéricas a evolução da composição genética de uma população, dando atenção especial ao processo dinâmico conhecido como catraca de Muller, que é responsável pela degradação da população devido ao acúmulo de mutações deletérias em populações finitas. Consideramos também a genealogia dos indivíduos em uma população sob a ação da catraca de Muller. Ainda, investigamos analiticamente o limite determinístico do modelo, no qual o tamanho da população é infinito, onde o processo da catraca não atua. O relevo replicativo, ou seja, a função que mapeia a carga genética de um indivíduo com a sua probabilidade de reprodução utilizado nesse trabalho é uma generalização do relevo originalmente proposto por Muller para ilustrar o processo da catraca. Adicionamos a esse relevo um parâmetro de epistase que simula a interação entre os sítios das seqüências dos indivíduos. A escolha desse parâmetro determina três tipos possíveis de epistase: (i) sinergística, no qual as mutações ficam cada vez mais deletérias com o número de mutações já existentes; (ii) atenuante, no qual o efeito deletério de uma nova mutação é atenuado; e (iii) multiplicativa, no qual as novas mutações causam danos idênticos, independentemente do número anterior de mutaçõesIn this work we investigate through numerical simulations the evolution of the genetic composition of a population, giving emphasis to the dynamic process termed Muller\'s ratchet, which is responsible for the degradation of the population due to the accumulation of deleterious mutations in finite populations. We consider also the genealogy of the individuals evolving in a population under the effect of the Muller\'s ratchet. In addition, we investigate analytically the deterministic limit of the model, in which the population size is infinite, where ratchet process does not act. The replication landscape, i.e., the function that maps the genetic load of an individual on its probability of reproduction used in this work is a generalization of that originally considered by Muller to illustrate the process of the ratchet. In particular, we add to that landscape a parameter of epistasis that models the interactions among the sites of the sequences of the individuals. The tunning of this parameter determines three different types of epistasis: (i) synergistic, where the mutations become more deleterious with the number of mutations already present; (ii) diminishing, where the deleterious effect of a new mutation is attenuated; and (iii) multiplicative, where the new mutations cause identical damages, independently of the previous number of mutations
22
Prostredníková, Hana. "Modelování na základě genealogických dat." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2018. http://www.nusl.cz/ntk/nusl-385903.
Abstract:
This thesis contains detailed study of given problems related to genealogy science and genealogical records. There are analyzed roles and relationships that occurs in genealogical records and problems of their representation are described too. The goal is to design and implement system, which will validate relationships in genealogical records and enable processing this data.
23
Panneerselvam, Madhumalar. "Pedigree tool /." Online version of thesis, 2008. http://hdl.handle.net/1850/11185.
24
Fanghanel, Alexandra Nadja. "For a genealogy of street-wisdom." Thesis, University of Leeds, 2010. http://etheses.whiterose.ac.uk/2774/.
Abstract:
The study of women’s fear of crime has received considerable academic attention from a range of disciplinary directions. This thesis propels these existing debates further forward by problematising the construction of ‘fear’ and ‘safety’ in existing work and by exploring the range of ways in which public spaces are understood, and knowledge about them constructed and deployed. Using a Foucauldian and affective theoretical framework, the thesis uncovers how safe or fearful ‘knowledges’ are constituted, and reconfigures them, beyond the limits of this lexicon, as ‘at-home-ness’ and ‘un-at-home-ness’. These terms offer both broader and more precise ways of speaking about the specificity of women’s day-to-day experiences of occupying public space. With this in mind, this thesis uses a mix of qualitative methods including Walking Interviews, Map Interviews and Multimedia Diaries to investigate, with 45 female participants across three sites in the South East of England, the ways in which they situate themselves physically and emotionally in their home towns. The study begins to excavate how this knowledge, or street-wisdom, is formed and circulated, reflecting the breadth of sometimes emancipatory, sometimes exclusionary or oppressed ways in which women experience their bodies in space. By adopting this nuanced perspective on fear of crime, and by proposing an understanding of fear of crime which is more complex and contingent than existing discussions suggest, this thesis offers challenging and instructive insights into the possibilities and problematics of fear when used to inform street-wisdom.
25
Bull, Vanessa Jane. "Genealogy and speciation in Heliconius butterflies." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408421.
26
Condilo, Camila da Silva. "Genealogy and textual authority in Herodotus." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709182.
27
Svensson, Kerstin. "Genetic genealogy and epidemiology of Francisella." Doctoral thesis, Umeå universitet, Infektionssjukdomar, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22452.
Abstract:
This thesis is about analyzing genetic differences among isolates of Francisella tularensis – the tularemia-causing bacterium. To elucidate how these bacterial isolates are related, and their geographical and genetic origins, I have developed typing assays for Francisella and used them to study the epidemiology of tularemia. Tularemia is an infectious disease of humans and other mammals found throughout the Northern Hemisphere. The severity of the disease depends on the type of F. tularensis causing the infection. In Sweden, as in other countries of Europe and Eurasia, tularemia is caused by F. tularensis subsp. holarctica, while other varieties of the bacterium occur in Middle Asia and North America. It is important to identify a tularemia infection promptly in order to initiate the correct antibiotic treatment. A rapid identification of the causative F. tularensis variety gives additional clinical information. In recent years, several genomes of various Francisella strains have been sequenced, and in this thesis, I have utilized these genomes to identify genetic markers. In studies reported in the first paper (I) appended to the thesis, we identified and analyzed insertion/deletion mutations (INDELs) inferred to have resulted from a sequence repeat-mediated excision mechanism. We found eight new Regions of Difference (RDs) among Francisella strains. Using RDs together with single nucleotide polymorphisms (SNPs), we were able to predict an evolutionary scenario for F. tularensis in which Francisella novicida was the oldest variety while F. tularensis subsp. holarctica was the youngest. We also found that all virulence-attenuated isolates analyzed had deletions at two specific genetic regions - denoted RD18 and RD19 – suggesting that repeat-mediated excision is a mechanism of attenuation in F. tularensis. In subsequent studies (presented in paper II), we developed a combined analysis of INDELs lacking flanking repeats and variable number of tandem repeats (VNTRs). Both markers could be assayed using the same analytical equipment. The inclusion of INDELs provided increased phylogenetic robustness compared with the use of VNTRs alone, while still maintaining a high level of genetic resolution. In analyses described in the next paper (III), we selected INDELs from paper (II) and discovered novel SNPs by DNA comparisons of multiple Francisella strains. Thirty-four phylogenetically informative genetic markers were included in a hierarchical real-time PCR array for rapid and robust characterization of Francisella. We successfully used the assay to genotype 14 F. tularensis isolates from tularemia patients and DNA in six clinical ulcer specimens. Finally, in paper (IV) we demonstrated a strategy to enhance epidemiological investigations of tularemia by combining GIS-mapping of disease-transmission place collected from patient interviews, with high-resolution genotyping of F. tularensis subsp. holarctica isolates recovered from tularemia patients. We found the geographic distributions of specific F. tularensis subsp. holarctica sub-populations to be highly localized during outbreaks (infections by some genotypes being restricted to areas as small as 2 km2), indicative of a landscape epidemiology of tularemia with distinct point sources of infection. In conclusion, the results acquired during the studies underlying this thesis contribute to our understanding of the genetic genealogy of tularemia at both global and local outbreak scales.
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Park, Joon. "Music, Motion, and Space: A Genealogy." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19354.
Abstract:
How have we come to hear melody as going “up” or “down”? Why does the Western world predominantly adopt spatial terms such as “high” and “low” to distinguish musical notes while other non-Western cultures use non-spatial terms such as “large” and “small” (Bali), or “clear” and “dull” (South Korea)? Have the changing concepts of motion and space in people’s everyday lives over history also changed our understanding of musical space? My dissertation investigates the Western concept of music space as it has been shaped by social change into the way we think about music today. In our understanding of music, the concept of the underlying space is so elemental that it is impossible for us to have any fruitful discourse about music without using inherently spatial terms. For example a term interval in music denotes the distance between two combined notes; but, in fact, two sonic objects are neither near nor far from each other. This shows that our experience of hearing interval as a combination of different notes is not inherent in the sound itself but constructed through cultural and social means. In Western culture, musical sound is often conceptualized through various metaphors whose source domains reflect the society that incubated these metaphorical understandings. My research investigates the historical formation of the conceptual metaphor of music. In particular, I focus on historical formation of the three underlying assumptions we bring to our hearing of music: (1) “high” and “low” notes and motion between them, (2) functionality of musical chords, and (3) reliance on music notation. In each chapter, I contextualize various music theoretical writings within the larger framework of philosophy and social theory to show that our current understanding of musical sound is embedded with the history of Western culture.
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Walker, Troy L. "Automating the Extraction of Domain-Specific Information from the Web-A Case Study for the Genealogical Domain." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd607.walker.
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Costa, Erica Atem GonÃalves de AraÃjo. "Element for a genealogy of contemporary child subjectivity based on critical-scientific discourses about childhood." Universidade Federal do CearÃ, 2006. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=145.
Abstract:
FundaÃÃo de Amparo à Pesquisa do Estado do CearÃCoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
This research discusses the naturalization of the idea of a âchild with a sayâ in contemporary critical-scientific discourses. This conception was constituted in these discourses so as to criticize the idea of modern childhood, related, among other things, to notions of immaturity and dependence on adults. The figure of subjectivity âchild with a sayâ is used to justify an ensemble of varied practices â juridical (âchild-witnessâ), political (âcitizen child"), mediatic (âprotagonist childâ), educational (âcompetent childâ) â which aims at investing on the child figure for which the constitution of a child as a subject of opinion and representation is determinant. The analysis of this discursive field â which comprises Sociology of Childhood, Anthropology of Childhood, Pedagogy of Childhood and Social Psychology â based on M. Foucaultâs archaeo-genealogy, identified the kinds of statements present in this network, as well as the kind of discourse used. It was noticed that the functioning of these discourses depends on some presuppositions, which, in this research, are denominated mechanisms of critical discursivity. They are: the development of the concept representations of childhood and child, the constitution of the adult as an interdictor, the rediscovery of childhood, speech as a natural possibility and the idealization of the âchildhood with a speechâ. It was concluded that such presuppositions cooperate to produce the âchildhood with a speechâ as evidence, to which knowledge must devote itself and experience. Finally, an assemblage of investigation lines were elaborated and served as a base for the constitution of a genealogy of this subjectivity figure, typical of present times.
Esta pesquisa discute a naturalizaÃÃo da idÃia da âcrianÃa com vozâ pelos discursos crÃtico-cientÃficos contemporÃneos. Essa concepÃÃo foi constituÃda nesses discursos com o objetivo de estabelecer uma crÃtica à idÃia de infÃncia moderna, ligada, dentre outras coisas, Ãs noÃÃes de imaturidade e dependÃncia em relaÃÃo ao adulto. A figura de subjetividade âcrianÃa com vozâ à utilizada para justificar um conjunto de prÃticas variadas - jurÃdicas (âcrianÃa-testemunhaâ), polÃticas (âcrianÃa cidadÃâ), midiÃticas (âcrianÃa protagonistaâ), educativas (âcrianÃa competenteâ) - que tÃm como alvo um tipo de investimento sobre o corpo infantil para o qual à determinante a constituiÃÃo da crianÃa como sujeito de opiniÃo e representaÃÃo. A anÃlise deste campo discursivo - do qual fazem parte a Sociologia da infÃncia, a Antropologia da infÃncia, a Pedagogia da infÃncia, a Psicologia social - a partir da arqueogenealogia de M. Foucault, levou à identificaÃÃo dos tipos de enunciado presentes nesta rede, assim como do tipo de discursividade em jogo. Viu-se que o funcionamento desses discursos depende de alguns pressupostos, os quais se denominam, nesta pesquisa, dispositivos da discursividade crÃtica. SÃo eles: a evoluÃÃo das concepÃÃes de infÃncia e crianÃa, a constituiÃÃo do adulto como um interditor, a redescoberta da infÃncia, a fala como uma possibilidade natural e a idealizaÃÃo da âinfÃncia que falaâ. Concluiu-se que tais pressupostos concorrem para a produÃÃo da âinfÃncia que falaâ como uma evidÃncia, à qual os saberes devem se dedicar a conhecer. Por Ãltimo, elaborou-se um conjunto de linhas de investigaÃÃo que poderiam servir de base à constituiÃÃo de uma genealogia dessa figura de subjetividade caracterÃstica do presente.
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Oliveira, Márcia Rezende de. "Ecce homo, a fisio-psicologia de um tipo." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/8/8133/tde-07022008-111019/.
Abstract:
No presente estudo, pretendemos realizar uma leitura de Ecce homo balizada pelo procedimento genealógico, pela fisio-psicologia e pela tipologia presentes no pensamento de Nietzsche. Acreditamos que a mudança que se opera no tratamento do humano a partir dessas três noções permite a Nietzsche, em Ecce homo, realizar uma espécie de duplo movimento. Por um lado, o filósofo realiza a máxima afirmação da vida e de si mesmo, dando expressão a uma série de estados afetivos que o constitui. Por outro lado, ao afirmar-se, Nietzsche marca oposição -- e nisso talvez certa transvaloração -- a um estado de coisas marcado pela desvalorização da efetividade. Nossa hipótese é de que podemos ler a obra em questão como sendo a apresentação de um tipo, o \"tipo Nietzsche\". O Nietzsche que se conta em Ecce homo é aquele que se constitui em oposição à moral socrático-platônico-cristã que predomina no ocidente. E mais que isso é um tipo que, segundo o filósofo, possui o pathos filosófico dionisíaco, ou seja, o tipo forte, saudável e que tem como prerrogativa a afirmação da vida.This study intends to do a reflection of Ecce Homo embossed by the genealogical procedure, by the physio-psychology and the typology present in Nietzsche\'s thought. We believe that the change that takes place in the treatment of the human from these three notions, allows Nietzsche, in Ecce Homo, to do a type of double movement. In one hand, the philosopher reaches the maximum affirmation of life and oneself, giving expression to a series of affectionate states that constitute him. On the other, in affirming himself, Nietzsche marks an opposition - and with that a certain transvaluation - to a state of things marked by the devaluation of effectiveness. Our hypothesis is that we can read this work as being a presentation of a type, the \"Nietzsche type\". That Nietzsche which narrates himself in Ecce Homo is the one that is constituted in opposition to the Socraticplatonic- Christian moral that prevails on the West. Moreover, it\'s a type that, according to the philosopher, owns the Dionysius philosophical pathos, or, the strong type, healthy, that has as its prerogative the affirmation of the life.
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Gomes, Leonardo Gonçalves [UNESP]. "Sobre a teleoformidade na formação humana: um olhar genealógico." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/91245.
Abstract:
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A partir dos termos (areté), (paidéia), humanitas e Bildung, a noção de formação humana remonta ao próprio percurso da história e filosofia da educação no Ocidente. Ao passo que tarefa formativa é formar integralmente o humano delineando um êthos, um modo de vida, a fixação de uma ordem do discurso acerca da formação apresenta-se como um ponto estratégico ao passo que possibilita a manutenção de determinadas formas de vida e de relações de força na sociedade. Sob o prisma biopolítico, uma ordem discursiva põe em funcionamento diversas tecnologias de administração dos modos de vida dos sujeitos por meio das instituições voltadas à formação, tanto através da disciplina dos corpos individualizados, quanto ao nível populacional do controle da espécie mediante a normalização. Desta forma, colocamos uma questão ao nosso presente: ao retomar os sentidos demarcados pela tradição formativa face ao governo biopolítico, de que modo podemos situar os limites e as possibilidades dos discursos sobre formação na atualidade? Seguindo a perspectiva genealógica procuramos apontar caminhos para responder a questão partindo de uma dupla tarefa. Por um lado, retomar a trama histórica que fundamentou a noção de formação em torno de areté, paidéia e humanitas, no mundo greco-romano antigo, e Bildung, no contexto moderno alemão. E por outro, procuramos indicar relações de poder e saber que sustentam esses discursos formativos, caracterizando a noção por nossa pesquisa desenvolvida: a teleoformidade – noção que permite localizar formas e fins que direcionam e embasam os discursos formativos, segundo um horizonte delineado por uma imagem de caminho e de...
Based on the terms (areté), (paidéia), humanitas and Bildung, the notion of human formation takes us back to the course of education history and philosophy in the Occident. Once the formation task consists in wholly form the human person outlining an êthos, a way of life, the setting of the speech order around formation shows up as an strategic point, while it allows the maintenance of certain forms os life and power relations in society. Beneath biopolitics aspect, a speech order takes place on many ways of life's management technologies, through the institutions focused on formation, be it through the discipline of individualized bodyes, be it through the population level control of the specie by means of normalization. Thereby, we question our present times: by retaking the senses fixed by the formative tradition in its relations with biopolitics governament, how can we place the limits and possibilities around formation speeches nowadays? Following the genealogic perspective, we intend to indicate some ways that may answer this question, through two tasks. On the one hand, to retake the historical plot wich based the formation notion around areté, paidéia e humanitas in ancient greco-roman world, e Buildung in modern german context. In the other hand, we try to indicate knowleadge and power relations that support these formative speeches. The notion developed by our research is described by teleoformity – the idea allows us to locate forms and aims that base and orientates the formative speeches, according to a horizon bounded by an image of way and of the ethos improvement. Thereby, our study was organized in two basal parts. In the first part, we present the speech guided by a supposed universal... (Complete abstract click electronic access below)
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Guimarães, Lilian de Oliveira. "Polimorfismos genéticos em genes relacionados com imunidade inata em população de área de baixa endemicidade para malária." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-31012018-154340/.
Abstract:
Os receptores do tipo toll (toll-like receptors ou TLRs) são uma família de receptores na primeira linha de defesa do sistema imune inato que são capazes de reconhecer padrões moleculares associados a patógenos (PAMPs), dentre os patógenos mais importantes encontra-se Plasmodium. Variações genéticas nesses receptores estão associadas à resistência ou suscetibilidade a uma variedade de doenças infecciosas. Sabe-se que as freqüências destas mutações também podem variar de acordo com a ancestralidade biogeográfica dos indivíduos. Este trabalho avaliou a relação entre 24 polimorfismos em TLRs, ancestralidade e malária em 195 indivíduos residentes em área de Mata Atlântica do Estado de São Paulo. A ancestralidade genômica individual foi estimada usando marcadores autossômicos de inserção/deleção (INDELs) e os polimorfismos em TLR foram genotipados por PCR-RFLP, sequenciamento e eletroforese capilar. Dados prévios de malária presente ou pregressa obtidos por métodos moleculares e sorológicos foram utilizados para avaliar a relação dos polimorfismos em TLRs e malária nesses indivíduos. Os resultados mostraram que: (i) nove SNPs e um microssatélite foram polimórficos; (ii) a maior parte dos indivíduos analisados apresentou maior proporção de ancestralidade europeia; (iii) as proporções médias de ancestralidade europeia diferiram significantemente nos genótipos de TLR1 (I602S) e TLR6 (P249S); (iv) a probabilidade de ter o alelo variante G em TLR1 aumenta com o aumento da ancestralidade européia assim como aumenta a probabilidade de ter o alelo variante T no TLR6; (v) o polimorfismo em TLR9 -1237T/C foi fortemente relacionado à malária, sendo demonstrado que a presença de pelo menos um alelo C nessa posição aumentou o risco para malária 2,3 vezes; e (vi) TLR9 -1486T/C em associação com o TLR6 foi protetor, pois a associação dos alelos variantes reduziu o risco de malária em 4,4 vezes. O alelo G em TLR1 tem sido relacionado a uma resposta imune diminuída, o que poderia explicar a alta prevalência de casos de malária assintomática em áreas do sudeste brasileiro. O TLR9 tem sido relacionado com a patogênese da malária em estudos em animais e em humanos, sendo possivelmente modulado por polimorfismos na região promotora. Nossos dados também reforçam a necessidade de incluir marcadores de ancestralidade em estudos de associação genética para evitar resultados enviesados. Por fim, este é o primeiro estudo a associar polimorfismos em genes de imunidade inata e malária em amostras de Mata Atlântica.Toll-like receptors (TLRs) are a family of receptors in the first line of defense of the innate immune system and they are able to recognize molecular patterns associated with pathogens (PAMPs), among the most important pathogens is Plasmodium. Genetic variations in these receptors are associated with resistance or susceptibility to a variety of infectious diseases. It is known that the frequencies of these mutations can also vary according to the biogeographic ancestry of the individuals. This work evaluated the relationship among 24 polymorphisms in TLRs, ancestry and malaria in 195 individuals living in the Atlantic Forest area of the São Paulo State. Individual genomic ancestry was estimated using autosomal insertion/deletion markers (INDELs) and TLR polymorphisms were genotyped by PCR-RFLP, sequencing and capillary electrophoresis. Previous data about present or previous malaria were obtained by molecular and serological methods and were used to evaluate the relationship of polymorphisms in TLRs and malaria in these individuals. The results showed that: (i) nine SNPs and one microsatellite were polymorphic; (ii) the majority of the individuals analyzed presented a greater proportion of European ancestry; (iii) the average proportions of European ancestry differed significantly in the genotypes of TLR1 (I602S) and TLR6 (P249S); (iv) the probability of having the variant G allele in TLR1 increases with increasing European ancestry as well as increases the probability of having the T allele variant in TLR6; (v) the TLR9 -1237T/C polymorphism was strongly related to malaria, and the presence of at least one C allele in this position was shown to increase the risk for malaria 2.3 times; and (vi) TLR9-1486T/C in combination with TLR6 was protective, since the association of variant alleles reduced the risk of malaria by 4.4 times. The G allele in TLR1 has been related to a decreased immune response, which could explain the high prevalence of cases of asymptomatic malaria in areas of southeastern Brazil. TLR9 has been linked to the pathogenesis of malaria in animal and human studies, possibly being modulated by polymorphisms in the promoter region. Our data also reinforce the need to include ancestral markers in genetic association studies to avoid biased results. Finally, this is the first study to associate polymorphisms in genes of innate immunity and malaria in Atlantic Forest samples.
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Noto, Carolina de Souza. "A recusa do transcendental: um estudo sobre a filosofia crítica de Foucault." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/8/8133/tde-07112014-193129/.
Abstract:
A hipótese desse trabalho é a de que é possível encontrar uma unidade sistemática no pensamento filosófico de Michel Foucault. Desde os escritos arqueológicos da década de 60 até as últimas considerações, arqueológicas e genealógicas, sobre a ética e a subjetividade, o que se vê é um tipo de reflexão filosófica que concilia uma discussão sobre a linguagem e uma sobre o homem. Tratase, então, de mostrar como, metodologicamente, Foucault constrói tal reflexãoThe hypothesis of this work is that it is possible to find a systematic unity in Michel Foucaults philosophical thought. From his archaeological writings produced in the 1960s to the last archaeological and genealogical considerations on ethics and subjectivity, one notices a kind of philosophical reflection that conciliates a discussion about language and a discussion about man. This research shows how Foucault methodologically constructs that reflection
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Guirao, Marcio Pinotti. "Sobre a ocorrência e a genealogia de amostras brasileiras de Coronavirus canino (CCoV) e o papel de cães como reservatórios para Rotavirus." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-29012010-084501/.
Abstract:
Gastrenterites virais em cães são doenças transmissíveis infecciosas com importância para a saúde animal, como as causadas por Parvovírus canino e Coronavírus canino (CCoV) e saúde pública, como no caso dos rotavírus. Rotavírus em cães são encontrados com baixa freqüência, tanto em cães com diarréia quanto sadios, mas sua importância como reservatório para a rotavirose humana já é conhecido. O CCoV, pertencente ao grupo 1 do gênero Coronavirus, ocorre sob a forma dos genótipos I e II, amplamente distribuídos mundialmente e implicados em diarréia moderada, mas podendo levar a elevada letalidade no caso de patótipos altamente patogênicos. No Brasil, a ocorrência de rotavírus do sorogrupo A em cães é um fato conhecido, mas, no caso do CCoV, existe, até o momento, apenas uma investigação relatando sua ocorrência, sem dados de diversidade molecular. A presente investigação teve por objetivos avaliar o papel de cães jovens com enterite sintomática, bem como sadios, como reservatórios de rotavírus, estudar a freqüência de ocorrência de Coronavírus canino (CCoV) em amostras fecais destes animais e estudar a diversidade molecular das amostras de CCoV encontradas. Para tato foram colhidas 100 amostras fecais de cães não vacinados, entre 1 e 180 dias de idade entre 2007 e 2008, sendo 50 com diarréia e 50 sem diarréia no momento da colheita, nos Municípios de São Paulo, São Bernardo do Campo, Santo André, São Caetano do Sul, Taboão da Serra, Itapecerica da Serra e uma aldeia indígena em Parelheiros. Às amostras foi aplicada a técnica de eletroforese em gel de poliacrilamida (PAGE) para a detecção de rotavírus e uma RT-PCR dirigida ao gene da proteína de membrana M do CCoV (nucleotídeos 337 a 746) para a detecção deste vírus, sendo os fragmentos detectados submetidos a seqüenciamento de DNA. As seqüencias obtidas, traduzidas em aminoácidos, foram utilizadas para a construção de uma árvore genealógica enraizada de distância com o algoritmo Neighbor-Joning e modelo de Poisson com 100 repetições de bootstrap. Nenhuma das amostras resultou positiva para rotavirus, enquanto que 47 foram positivas para CCoV, com freqüência significativamente superior nos animais com diarréia. Vinte e dois dos 47 fragmentos de DNA obtidos resultaram em seqüências viáveis de DNA, sendo 12 classificadas como CCoV Tipo I e 10 como Tipo II, tendo sido encontrada uma sublinhagem exclusivamente brasileira para o Tipo II. Em relação à amostra vacinal de CCoV submetida ao seqüenciamento de DNA, a maior identidade ocorreu com o grupo Tipo II sublinhagem 01, com um valor de 100%, seguido de 97,2% para o Tipo II sublinhagem 02 (a linhagem brasileira) e 93,2% para o Tipo I. Sugere-se que a diversidade de CCoV encontrada seja derivada da elevada freqüência de ocorrência deste vírus, o que pode aumentar a probabilidade de divergências e de possíveis falhas vacinais por diferenças entre a amostra vacinal (Tipo II) e as amostras de campo (Tipos I e II), e, dessa forma, a vacina não diminuiria a transmissão e novas linhagens de CCoV emergiriam. Conclui-se que cães jovens com enterite sintomática, bem como sadios, não tiveram papel como reservatório para rotavírus, considerando-se a região geográfica e o período de colheita de amostras. O CCoV ocorreu com uma freqüência de 47% na população canina estudada, com freqüência estatisticamente significativamente superior naqueles com diarréia do que naqueles sem diarréia. Finalmente, amostras brasileiras de CCoV, com base em seqüenciamento parcial do gene codificador da proteína de membrana M, ocorrem tanto como tipo I quanto II, sendo que, para o tipo II, há uma lihangem tipicamente brasileira.Viral canine gastroenteritis is infectious transmissible diseases with importance for animal health, as those caused by Canine parvovirus and Canine coronavirus (CCoV) and public health, as in the case of rotavirus. Canine rotavirus occurs at low frequencies, both in diarrheic and health dogs, but the importance of dog as reservoirs for human rotaviruses is known. CCoV belongs to group 1 of the genus Coronavirus and occurs as genotypes I and II, worldwide distributed and implicated in mild diarrhea, but high pathogenic types might lead to high lethality. In Brazil, the occurrence of serogroup A rotavirus in dogs is already known but, in the case of CCoV, theres a single report on the occurrence of this virus, with no data on its molecular diversity. The aims of the present investigation were to evaluate the roles of diarrheic and health young dogs as reservoirs of rotavirus, to study the occurrence of CCoV in these animals and to assess the molecular diversity of the strains found. One hundred fecal samples were collected from unvaccinated dogs between 2007 and 2008 (50 with diarrhea and 50 health dogs) in the Municipalities of São Paulo, São Bernardo do Campo, Santo André, São Caetano do Sul, Taboão da Serra, Itapecerica da Serra and in an indian community in Parelheiros. The samples were submitted to polyacrilamide gel electrophoresis (PAGE) for rotavirus detection and to an RT-PCR targeted to the membrane M protein gene (nucleotides 337 to 746) of CCoV for the detection of this virus; amplicons were then submitted to DNA sequencing and the putative amino acids sequences were used to build a rooted distance genealogic tree with the Neighbor-Joinng algorithm and he Poisson correction with 1,000 bootstrap replicates. No sample was positive to rotavirus, while 47 out of the 100 samples were positive for CCoV, with a statistically significative higher frequency for the dogs with diarrhea. Twenty-two out of the 47 ampicons resulted in viable sequences, being 12 classified as CCoV Type II and 10 as Type I; besides, and exclusively Brazilian sub lineage was found for Type II. Regarding the vaccine strain, the highest identity was found to Type II sub linage 02 (10%), followed by 97.2% for Type II sub linage II (the Brazilian sub linage) and 93.2% for Type I. Its suggested that the high diversity for CCoV detected is a consequence of the high frequency of occurrence of this virus, what might increase the probability of the emergence of divergence and possible vaccine failures due to differences amongst the vaccine strain (Type II) and field strains (Types I and II) and thus vaccination would not decrease the transmission and new lineages would emerge. It can be concluded that both health and diarrheic young dogs have played no role as reservoirs for rotavirus taking into account the geographic area and the time of samples collection. CCoV ocurred at a frequecy of 47%, with a higher frequency in the diarreic animals. Finally, Brazilian strains of CCoV, based on partial M gene sequences, occur as both type I and II, while, for Type II, a typical Brazilian lineage was described.
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Leal, Luciano Da Rosa. "Estrutura populacional e diversidade genética da raça árabe no Brasil." Universidade Federal do Pampa, 2015. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/501.
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Reconhecida como uma das raças equinas mais antigas e influentes, o cavalo Árabe tem sua origem indefinida e supostamente heterogênea, a partir dos resultados de estudos de DNA-mitocondrial, que apontaram importante diversidade genética. Considerando o contexto dos desafios ecológicos a que as espécies são submetidas, tais como competição, predação, patologias e outros, a diversidade genética é fundamental na sua adaptação e evolução. Sua avaliação dentro da população é necessária durante a implementação do programa de seleção para estabelecer uma gestão apropriada do estoque genético, sendo determinada pelo tamanho da população base, mas também pelas estratégias de acasalamento. A análise genética de uma população pode ser levada a termo utilizando-se informação genealógica ou molecular. No caso do presente estudo, seu objetivo foi avaliar a diversidade genética do cavalo Árabe no Brasil, através das informações genealógicas contidas do Stud Book Brasileiro do Cavalo Árabe. Foram utilizados os dados de 54506 animais, cuja consistência de seus pedigrees foi avaliada pelo programa Breed Mate Pedigree Software® e os parâmetros populacionais determinados pela análise com o programa Poprep. A idade média dos machos e fêmeas em reprodução foi, respectivamente, 9,8 e 9,0 anos. A rotatividade de éguas em reprodução pode ser considerada alta (59,02%) e o intervalo médio de gerações ao longo do tempo considerado foi de 9,1 anos. Para a análise da endogamia foram definidas 11 classes com intervalos de 5%, onde 4,32% da população correspondeu a níveis acima dos 10%. A média F de endogamia encontrada para a população foi de 1,98%, considerando-se os dados de ancestrais desde 1808, e 2,90%, considerando-se os dados a partir de 1964, quando da criação do Stud Book Brasileiro do cavalo Árabe. Estes resultados são inferiores a alguns encontrados para populações de cavalos Árabes na Europa, observando-se ampla diversidade genética populacional, podendo estar relacionados ao considerável tamanho da população, ao fluxo gênico de um grande número de importações de animais e à ausência de gargalos genéticos importantes. Todavia, a elevada proporção de animais endogâmicos na população e o aumento das médias de endogamia nas últimas duas décadas, sugerem ajustes de seleção, no sentido de prevenir perdas de diversidade genética no futuro.
Recognized as one of the oldest and most influential horse breeds, the Arabian horse has an undefined and, supposedly heterogeneous origin, from the study results of mitochondrial-DNA, which indicate that significant genetic diversity. Considering the context of the ecological challenges that species are submitted, such as competition, predation, disease and others, genetic diversity is crucial in adaptation and evolution. Evaluation within the population is necessary for the implementation of the screening program to establish a proper management of the genetic stock, being determined by the size of the base population, but also for mating strategies. Genetic analysis of a population may be brought to completion by using family or molecular information. In the present study, its purpose was to evaluate the Arabian horse genetic diversity in Brazil, through the genealogical information in the Stud Book Brazilian Arabian Horse. The data of 54,506 animals were used, whose consistency was assessed by their pedigrees Breed Mate Pedigree Software® program and population parameters determined by analysis with Poprep program. The average age of males and females in reproduction was respectively 9.8 and 9.0 years. The turnover of mares in breeding can be considered high (59.02%) and the average generation interval over time considered was 9.1 years. For the analysis of inbreeding 11 classes were defined with 5% intervals where 4.32% of the population corresponded to levels above 10%. The average F of inbreeding found for the population was 1.98%, considering the data ancestors since 1808, and 2.90%, considering the data from 1964, when the creation of the Brazilian Stud Book of Arabian horse. These results are lower than those found in populations of Arabian horses in Europe, observing large population genetic diversity and may be related to the large size of the population, the gene flow of a large number of animal imports and the absence of important genetic bottlenecks. However, the high proportion of inbred animals in the population and the increase in mean inbreeding in the past two decades, suggest selection of adjustments, in order to prevent loss of genetic diversity in the future.
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Jacob, Frederike Juliane Verfasser], Ulrike [Akademischer Betreuer] Haß, and Monika [Akademischer Betreuer] [Schmitz-Emans. "Genealogy Trouble: Studien zu einer Geschichte der Genealogie / Frederike Juliane Jacob. Gutachter: Ulrike Haß ; Monika Schmitz-Emans." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1089007310/34.
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Jacob, Frederike Juliane [Verfasser], Ulrike [Akademischer Betreuer] Haß, and Monika [Akademischer Betreuer] Schmitz-Emans. "Genealogy Trouble: Studien zu einer Geschichte der Genealogie / Frederike Juliane Jacob. Gutachter: Ulrike Haß ; Monika Schmitz-Emans." Bochum : Ruhr-Universität Bochum, 2016. http://nbn-resolving.de/urn:nbn:de:hbz:294-46771.
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Jacob, Frederike Juliane [Verfasser], Ulrike Akademischer Betreuer] Haß, and Monika [Akademischer Betreuer] [Schmitz-Emans. "Genealogy Trouble: Studien zu einer Geschichte der Genealogie / Frederike Juliane Jacob. Gutachter: Ulrike Haß ; Monika Schmitz-Emans." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1089007310/34.
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Bourne, James. "A genealogy of the personality disorder construct." Thesis, University of East London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532925.
Abstract:
Personality disorder is a commonly diagnosed set of psychiatric disorders that are used to denote a stable and enduring pattern of experience and behaviour that deviates markedly from cultural expectations. The construct is widely acknowledged to be problematic on the grounds of its scientific reliability and validity and there is a debate in the literature regarding the re-conceptualisation of personality disorder using a dimensional model. This study employs a genealogical methodology to carry out a philisophico-historical analysis of the politio-medical conditions of emergence of the construct. The work looks at the way in which disparate discourses have transformed and merged to take on increasingly essentialist, scientised and rarefied forms during the course of the twentieth century. The emergence of personality as a multi-dimensional statistically knowable phenomenon amenable to professional and technical management is also explored. The study goes on to apply the ideas from two papers, Leeming and Boyle's (2004) paper on Shame as a social phenomenon and Moncrieff's (2008) chapter on Neoliberalism and Psychiatry, to the historical material drawn upon, in order to explore possible implications from a psychological as well as a political perspective. There are some concluding remarks on the possible value of reflexivity when attempting to address complex issues. 3
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Lobo-Guerrero, Luis. "Emerging securities : a biopolitical genealogy of insurance." Thesis, Lancaster University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507314.
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Dorsett, Shaunnagh Law Faculty of Law UNSW. "Thinking jurisdictionally: a genealogy of native title." Awarded by:University of New South Wales. School of Law, 2005. http://handle.unsw.edu.au/1959.4/23963.
Abstract:
In Mabo v. State of Queensland (No. 2) (1992) 175 C.L.R. 1, the majority of the High Court held that ???native title??? had survived the acquisition of sovereignty over the Australian continent and is ???recognised??? by the common law. However, all the judgments failed to articulate clearly either the nature of native title as a legal form, and the relationship of that legal form to the common law, or what is meant by ???recognition???. Twelve years later the High Court has still not provided a satisfactory understanding of any of these matters. The central problem investigated by this thesis is the nature of that relationship and of the legal interest of native title. It is contended that this relationship can be understood and ordered as a matter of jurisdiction. This thesis seeks to recuperate a substantive concept of jurisdiction, and specifically of a particular jurisdiction, that of the common law, and to demonstrate how the interest of native title results from the jurisdictional relationship between common law and indigenous law. Part I is a genealogy of native title, drawn out through a history of ideas about common law jurisdiction. It is an account of the legal practice of jurisdiction, through a conceptual elaboration of a particular jurisdiction: the common law. This part traces the history of the common law from its origins in a pluralistic, fragmented, jurisdictional landscape, to its current position as the ???law of the land???. It considers the traditional mechanisms and techniques through which the common law has ordered its relationships with other jurisdictions, and how it has appropriated matters traditionally within the purview of other jurisdictions, accommodating them within the common law as ???custom???. The thesis demonstrates that the same gestures and practices can be seen in modern native title decisions, and contends that the ordering which underpins both native title, and the Australian legal system, is jurisdictional. Part II examines the practice of jurisdiction through an examination of three technologies of jurisdiction, all of which contributed to the construction of the legal entity of native title as an act of jurisdiction: mapping, accommodation and categorisation.
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Rader, Richard Evan. "Shadows on the son Aeschylus, genealogy, history /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189987057.
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Nichols, Alan W. "On Foucault and the genealogy of governmentality." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4818.
Abstract:
Thesis (Ph. D.)--University of Missouri-Columbia, 2007.The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on February 26, 2008) Vita. Includes bibliographical references.
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Childerhose, Janet Elizabeth. "Genetic discrimination: genealogy of an American problem." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86665.
Abstract:
Genetic discrimination has been transformed from an isolated concern of a handful of professionals into a pressing civil rights and public policy problem in the United States over the last twenty years. My dissertation is a genealogical account of how genetic discrimination has been shaped into a problem of this stature. It answers two questions: Where did the problem come from? How has the problem changed over time?In Part One, I trace the history of concerns about discrimination from the 1970s to the present. Drawing from oral histories with key actors and organizations that shaped early public understanding of the problem, I show that concerns about genetic discrimination originated in diverse practices. These practices include workplace genetic screening, insurer discrimination against individuals with AIDS, the rapid commercialization of genetic tests in the 1980s, and health care reform.
In Part Two, I present findings from a three-year ethnographic study of public policy hearings on genomic medicine in the United States that illustrate how new actors have been defining the problem of genetic discrimination since 1995. The hearings of the Secretary's Advisory Committee on Genetics, Health and Society were a site where participants legitimized genetic discrimination as a civil rights problem and developed lobbying tools to persuade Congress to pass federal nondiscrimination legislation. Participants framed fear of discrimination as a barrier to the nation's scientific progress and a significant threat to the lives of Americans.
I use the construct of genomic citizenship to draw out claims about the rights and duties of Americans in contemporary discourse on genetic discrimination. Passing federal nondiscrimination legislation is one way in which the civil rights of Americans appear to be expanding, while their responsibilities to act genetically are increasing. Advocates of nondiscrimination legislation, who use the language of genetic defect to argue that everyone is vulnerable to discrimination, geneticize all Americans by enrolling them into the biosociality of the flawed, transparent genome, with attendant duties. What these advocates do not also champion is the right of Americans to refuse to think or act genetically.
La discrimination génétique est passée du statut de préoccupation isolée parmi un petit nombre de professionnels à celui d'un urgent problème de droits civils et de politique publique aux État-Unis, depuis les vingt dernières années. Ma thèse est un compte rendu généalogique de la transformation de la discrimination génétique en un problème d'une telle envergure. Elle répond à deux questions : Quelle est l'origine du problème? Comment le problème a-t-il changé avec les années?
Dans la première partie, je retrace l'histoire des préoccupations au sujet de la discrimination, des années 70 à aujourd'hui. Je puise dans la tradition orale chez des acteurs clés et des organismes de premier plan qui ont informé la compréhension initiale du problème par le public. Je montre comment les préoccupations entourant la discrimination génétique sont issues de différentes pratiques.
Dans la deuxième partie, je présente les résultats d'une étude ethnographique d'une durée de trois ans, traitant des audiences publiques sur la médecine génomique aux États-Unis, et illustrant comment de nouveaux acteurs ont défini le problème de la discrimination génétique depuis 1995. Dans le cadre des audiences du Secretary's Advisory Committee on Genetics, Health and Society, les participants ont identifié la peur de la discrimination comme un obstacle au progrès scientifique de la nation, de même qu'une menace significative pour la vie des Américains et des Américaines.
J'ai recours à la construction de citoyenneté génomique dans le but de dégager des revendications au sujet des droits et devoirs des Américains et des Américaines, en rapport avec le discours actuel sur la discrimination génétique. L'adoption d'une législation de non discrimination semble contribuer à l'élargissement des droits civils des Américains et des Américaines, tandis que s'accroît leur responsabilité d'agir sur le plan génétique. Les défenseurs de la législation de non discrimination emploient le langage des défaut génétiques pour soutenir que toute la population est sujette à la discrimination. Selon ces mêmes défenseurs, les Américains et Américaines n'ont pas le droit de refuser de penser ou d'agir en termes génétiques.
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Kao, Kuo-Kuei. "Love in sociological thought : a conceptual genealogy." Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/16788.
Abstract:
This thesis conducts a conceptual genealogy of love in sociological thought. It traces the passage of a positive logic of love: a disappearing logic conceived in Goethe's art, cultivated from the social science of Comte and Marx to classical non/Marxist sociology, and finally extinguished by late/modern reflexive sociology. Recovering the lineage of Comte, Durkheim and Parsons, it defends an economic politics of love in the positivist tradition against the political culture of classical sociology and the bio-politics of current sociology. After the demise of Marxist political economy, it examines a new order of love transversal to the socialist and capitalist organizations. The tripartite thesis argues that the sociological tradition has been tarrying with a social order of love evolved from Goethe's ethic of death and renunciation. This order expresses a disorganizing phenomenology of fate as the modern world traverses from the fated causes. to fatal consequences of love. In the causal loop, the fated-fatal order of love encounters the act, freedom and risk in a multiple unfolding of reality with minimal difference. Part I explores how a religious-political belief of fetishism practiced by Comte and Marx comes across its fate in the historical act. Part 11 explicates why a cultural-political calling for fraternity theorized by classical non/Marxist sociologists runs up against its fate in sexual freedom. Part Ill reveals that a bio-political interest in reflexivity methodized by late/modern sociologists tumbles upon its fate in social risk. In conclusion, however, the thesis suggests that an event of posthumous life after the liberation of humanity continues to occur in a state of emergency because the passion for fate escalating from social science to sociology is driven by an unrequited love of Humanity.
47
Rader, Richard Evan Jr. "Shadows on the Son: Aeschylus, Genealogy, History." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1189987057.
48
Powers, Mary Melinda. "A genealogy of corporeal culture in Bakchai." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1383468101&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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Andersen, Morten Skumsrud. "A genealogy of the balance of power." Thesis, London School of Economics and Political Science (University of London), 2016. http://etheses.lse.ac.uk/3326/.
Abstract:
The Balance of Power is one of the foundational concepts for the academic discipline of International Relations. Most treat it as a theoretical or analytical concept – a tool that scholars use to investigate the workings of world politics. However, there is a gap in the literature on the balance of power; it is also a concept used by political practitioners and diplomats in concrete debates and disputes throughout centuries. No one has systematically investigated the concept as a ‘category of practice’, and I seek to redress this omission. I ask, how, why, and with what effects has the balance of power concept been deployed across different contexts? This is important, because the discipline needs to investigate the histories of its dominant concepts – the balance of power deserves attention as an object of analysis in its own right. I combine a genealogical reading (by what accidents of history did we end up here?) with conceptual history (how was the balance used then as a rhetorical resource in making arguments?). The result is a history of practical international thought. I trace the trajectory of the balance of power concept empirically and concretely – from its emergence in England based on a domestic republican tradition, to its elaboration at the British-founded University of Göttingen in Hanover, on to Prussia and Germany, before finally ending up in the USA with the emergence of IR as a discipline. Throughout this trajectory, the concept of the balance of power has been centrally linked to what historical actors took to be European polities and their relations. In this trajectory, ‘shifts’ in the balance of power, is governed more by how the concept itself is deployed, than any material or territorial assessment of power alone, or by any deliberate refinement of the concept. It has affected and constituted international politics and foreign policies across time, as well as our own discipline of IR.
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Lindes, Peter. "OntoSoar: Using Language to Find Genealogy Facts." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4133.
Abstract:
There is a need to have an automated system that can read family history books or other historical texts and extract as many genealogy facts as possible from them. Embley and others have applied traditional information extraction techniques to this problem in a system called OntoES with a reasonable amount of success. In parallel much linguistic theory has been developed in the past decades, and Lonsdale and others have built computational embodiments of some of these theories using Soar. In this thesis we introduce a system called OntoSoar which combines the Link Grammar Parser using a grammar customized for family history texts with an innovative semantic analyzer inspired by construction grammars to extract genealogical facts from family history books and use them to populate a conceptual model compatible with OntoES with facts derived from the text. The system produces good results on the texts tested so far, and shows promise of being able to do even better with further development.