Relevant bibliographies by topics / Gene upregulation

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Gene upregulation'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Gene upregulation.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Gene upregulation"

1

Christman, Karen L., Richard Sievers, Fang Qizhi, Kenneth Colley, and Randall J. Lee. "Myocardial ischemia induced upregulation of pleitrophin gene." Journal of the American College of Cardiology 41, no. 6 (March 2003): 393. http://dx.doi.org/10.1016/s0735-1097(03)81133-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Lee, H. "MUC8 mucin gene upregulation in chronic rhinosinusitis." Otolaryngology - Head and Neck Surgery 129, no. 2 (August 2003): P175—P176. http://dx.doi.org/10.1016/s0194-5998(03)01081-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Ozcan, Onder, Ahmet Korkut Belli, Esin Sakalli Cetin, Murat Kara, Ozgur Ilhan Celik, Mehmet Kaplan, Selami Ilgaz Kayilioglu, Cem Donmez, and Murat Polat. "Upregulation of SIRT1 gene in gastric adenocarcinoma." Turkish Journal of Gastroenterology 30, no. 4 (April 15, 2019): 326–30. http://dx.doi.org/10.5152/tjg.2019.18550.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Kok, C. H., A. L. Brown, P. G. Ekert, and R. J. D'Andrea. "Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML." Leukemia 24, no. 6 (April 29, 2010): 1239–43. http://dx.doi.org/10.1038/leu.2010.85.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Suradhat, Sanipa, and Roongroje Thanawongnuwech. "Upregulation of interleukin-10 gene expression in the leukocytes of pigs infected with porcine reproductive and respiratory syndrome virus." Journal of General Virology 84, no. 10 (October 1, 2003): 2755–60. http://dx.doi.org/10.1099/vir.0.19230-0.

Full text
Abstract:
Recent studies suggest that porcine reproductive and respiratory syndrome virus (PRRSV) may have immunomodulatory effects on the host immune system by upregulating interleukin (IL)-10 gene expression. To determine the effect of PRRSV on porcine cytokine gene expression in vivo, we infected pigs with either the European or North American strain of PRRSV and monitored cytokine gene expression in peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage cells (BALC) using a multiplex PCR assay. Our results showed that both European and North American strains of PRRSV significantly upregulated IL-10 gene expression in PBMC of infected pigs from 5 days post-infection (p.i.). In addition, upregulation of IL-10 and interferon (IFN)-γ gene expression was observed in BALC starting from 9 days p.i. The upregulation of cytokine gene expression in BALC was observed concurrent with an increased percentage of lymphocytes in the BALC population, suggesting a role for peripheral leukocytes in cytokine production in lungs. Our results showed that PRRSV infection resulted in an upregulation of IL-10 gene expression in vivo and that both European and North American strains induced comparable levels of IL-10 gene expression in the infected pigs, despite differences in the clinical signs. Our data support the notion that induction of IL-10 production may be one of the strategies used by PRRSV to modulate the host's immune responses, and this may contribute to the unique clinical picture observed following PRRSV infection.
APA, Harvard, Vancouver, ISO, and other styles
6

Schrimpf, C., K. Tim, U. Böer, M. Klingenberg, O. Teebken, and M. Wilhelmi. "Shear Stress Induces Vasoprotective Gene Upregulation in Pericytes." European Journal of Vascular and Endovascular Surgery 47, no. 6 (June 2014): 696–97. http://dx.doi.org/10.1016/j.ejvs.2014.03.035.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Simakou, Theodoros, Robin Freeburn, and Fiona L. Henriquez. "Gene expression during THP-1 differentiation is influenced by vitamin D3 and not vibrational mechanostimulation." PeerJ 9 (July 14, 2021): e11773. http://dx.doi.org/10.7717/peerj.11773.

Full text
Abstract:
Background In injury or infection, monocytes migrate into the affected tissues from circulation and differentiate into macrophages which are subsequently involved in the inflammatory responses. Macrophage differentiation and activation have been studied in response to multiple chemokines and cytokines. However, mechanical, and physical stimuli can also influence macrophage differentiation, activation, cytokine production, and phagocytic activity. Methods In this study the macrophage differentiation from THP-1 monocytes was assessed upon the stimulation with 1,25-dihydroxyvitamin D3 and 1,000 Hz vibrations, using qPCR for quantification of transcript expression. Vitamin D binds the vitamin D receptor (VDR) and subsequently modulates the expression of a variety of genes in monocytes. The effects of the 1,000 Hz vibrational stimulation, and the combined treatment of vitamin D3 and 1000 Hz vibrations were unknown. The differentiation of macrophages was assessed by looking at transcription of macrophage markers (e.g., CD14, CD36), antigen presenting molecules (e.g., HLA-DRA), transcription factors (e.g., LEF-1, TCF7L2), and mechanosensors (e.g., PIEZO1 and PKD2). Results The results showed that vitamin D3 induced THP-1 macrophage differentiation, which was characterized by upregulation of CD14 and CD36, downregulation of HLA-DRA, upregulation of the PKD2 (TRPP2), and an inverse relationship between TCF7L2 and LEF-1, which were upregulated and downregulated respectively. The 1,000 Hz vibrations were sensed from the cells which upregulated PIEZO1 and TCF3, but they did not induce expression of genes that would indicate macrophage differentiation. The mRNA transcription profile in the cells stimulated with the combined treatment was comparable to that of the cells stimulated by the vitamin only. The 1,000 Hz vibrations slightly weakened the effect of the vitamin for the regulation of CD36 and HLA-DMB in the suspension cells, but without causing changes in the regulation patterns. The only exception was the upregulation of TCF3 in the suspension cells, which was influenced by the vibrations. In the adherent cells, the vitamin D3 cancelled the upregulating effect of the 1,000 Hz vibrations and downregulated TCF3. The vitamin also cancelled the upregulation of PIEZO1 gene by the 1,000 Hz vibrations in the combined treatment. Conclusion The mechanical stimulation with 1,000 Hz vibrations resulted in upregulation of PIEZO1 in THP-1 cells, but it did not affect the differentiation process which was investigated in this study. Vitamin D3 induced THP-1 macrophage differentiation and could potentially influence M2 polarization as observed by upregulation of CD36 and downregulation of HLA-DRA. In addition, in THP-1 cells undergoing the combined stimulation, the gene expression patterns were influenced by vitamin D3, which also ablated the effect of the mechanical stimulus on PIEZO1 upregulation.
APA, Harvard, Vancouver, ISO, and other styles
8

Cros, Nathalie, Jacky Muller, Sophie Bouju, Geneviève Piétu, Chantal Jacquet, Jean J. Léger, Jean-François Marini, and Claude A. Dechesne. "Upregulation of M-creatine kinase and glyceraldehyde3-phosphate dehydrogenase: two markers of muscle disuse." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 2 (February 1, 1999): R308—R316. http://dx.doi.org/10.1152/ajpregu.1999.276.2.r308.

Full text
Abstract:
Muscle disuse induces substantial alterations in the highly plastic skeletal muscle tissues, which occur especially in antigravity slow muscles. We differentially screened a muscle cDNA array to identify modifications in gene profile expression induced in slow rat soleus muscle mechanically unloaded by hindlimb suspension as a model for muscle disuse. This study focused on muscle creatine kinase mRNA and protein and glyceraldehyde-3-phosphate dehydrogenase mRNA, which were found to be upregulated in unweighted muscles. These upregulations were analyzed over a 4-wk time course of hindlimb suspension and compared with variations in myosin heavy chain (MHC) isoforms while specifically focusing on type IIx MHC mRNA and protein. The two metabolic marker upregulations clearly preceded IIx MHC contractile protein upregulation. Muscle creatine kinase upregulation was shown to be an excellent, and the earliest, marker of muscle disuse at mRNA and protein levels.
APA, Harvard, Vancouver, ISO, and other styles
9

Falanga, Anna, Tiziano Barbui, and Frederick Rickles. "Hypercoagulability and Tissue Factor Gene Upregulation in Hematologic Malignancies." Seminars in Thrombosis and Hemostasis 34, no. 02 (March 2008): 204–10. http://dx.doi.org/10.1055/s-2008-1079262.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Otterburn, David M., L. Grier Arthur, Shaheen J. Timmapuri, Suzanne M. McCahan, and Marshall Z. Schwartz. "Proteasome gene upregulation: a possible mechanism for intestinal adaptation." Journal of Pediatric Surgery 40, no. 2 (February 2005): 377–80. http://dx.doi.org/10.1016/j.jpedsurg.2004.10.024.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Gene upregulation"

1

Roskvist, Karldiony. "Upregulation of CLIC1 gene in THP1 cells stimulated by lipopolysaccharides." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20260.

Full text
Abstract:
The NLRP3 inflammasome is a multiprotein complex that controls caspase-1 activation and the development of the pro-inflammatory cytokines IL-1 and IL-18, as well as pyroptosis. The NLRP3 inflammasome in murine macrophages is normally triggered by pathogen-associated molecular patterns as well as a variety of structurally unrelated stimuli. The exact mechanism of NLRP3 activation by such a diverse set of stimuli is unknown, although many signaling processes have been proposed, including cytosolic efflux and the inflow of certain ions. As a result, numerous studies have suggested that anion channels play a role in NLRP3 inflammasome formation, although no direct evidence of their participation has been found. This thesis project aims to measure the expressions level of CLIC1 before and after LPS treatment. The measurement was done with the help of reference genes. Using qPCR, potential reference genes were tested for their stability and evaluated by GenEx. The study identified GUSB and TBP as the most stable genes. Using the delta delta cq method, data from qPCR were normalized by reference genes. The results from this analysis showed an upregulation in the expression levels of CLIC1. These results showed that CLIC1 an anion channel plays a role in the activation and formation of the NLRP3 inflammasome and other inflammatory disorders such as oxidative stress. The study identified GUSB and TBP as reference genes in LPS stimulated THP-1 macrophages and an upregulation in the expression levels of CLIC1, leading to speculation that LPS stimulation leads to the translocation of CLIC1 to the plasma membrane and suggests the possibility to target CLICs to treat NLRP3-driven diseases.
APA, Harvard, Vancouver, ISO, and other styles
2

Furnish, Oehrtman Elizabeth Jean. "The role of gelsolin upregulation and overexpression in neurite outgrowth for PC12 cells." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3031599.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Grose, Richard Philip. "The molecular basis of embryonic wound repair." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322259.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Wang, Ling. "GATA-4 mediated upregulation of Kv 4.2 gene expression in mouse heart." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0016/MQ49662.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Jenkins, Richard Gisli. "Upregulation of cyclooxygenase-2 gene expression as a potential means of preventing pulmonary fibrosis." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272417.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Nicholl, Suzanne Maureen. "Neuropeptide Y receptor subtypes involved in the stimulation of ventricular cell hypertrophy and associated upregulation of gene expression." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343024.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Hester, Ian Wayland. "HALO, a novel bHLH-PAS protein induced by neuronal preconditioning and ischemia, mediates cytotoxicity through BAX gene upregulation." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27251.

Full text
Abstract:
Cortical spreading depression (CSD) induces waves of neuronal depolarization that confer neuroprotection to subsequent ischemic events in the rat brain. To gain insights into the molecular mechanisms elicited by CSD, we used representational difference analysis (RDA) to identify mRNA induced by potassium depolarization in vivo. We have isolated a cDNA encoding a novel bHLH-PAS protein distantly related to SIM2, termed HALO. Our results confirm that HALO mRNA and protein are rapidly and transiently expressed in cortical neurons following CSD but not following short duration ischemia, another form of pre-ischemic conditioning. In the untreated adult brain, HALO is expressed at low levels but is highly expressed during embryonic development in neuronal lineages. Surprisingly, delayed HALO expression is also observed following middle cerebral artery occlusion (MCAO) in rats. Reporter assays show that HALO is a transcriptional activator that associates with the bHLH-PAS sub-class co-factor ARNT2. Adenovirus-mediated expression of epitope-tagged HALO results in the direct induction of the Bax gene and sensitization of cultured cells to cytotoxic stress. Together, our data indicate that HALO is a novel bHLH-PAS transactivator transiently induced by preconditioning and that its sustained expression is detrimental. The identification of HALO may represent an important step in our understanding of the molecular mechanisms of brain preconditioning and injury.
APA, Harvard, Vancouver, ISO, and other styles
8

Kareem, Fakhriya Mohammed. "The influence of exogenously applied 'anti-stress' agents in the upregulation of the drought response in Iraqi wheat varieties." Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/10667.

Full text
Abstract:
Bread wheat (Triticum aestivum L.) is one of the most important cereal crops grown in the world. It has great importance because it constitutes a major source of carbohydrate for more than one third of the world’s population (Budak et al., 2013). In the last three decades, drought conditions are becoming more widespread in wheat production areas including Europe, Australia and Asia, and it is considered a major cause of reduced wheat growth and productivity in most developing countries with semi-arid climates. Drought constitutes the most important threat for wheat production in Iraq and especially for the Kurdistan Regional Governate owing to the limited source of water during at least some part of the growing period. Because wheat is considered a staple food and has economic importance for the Kurdistan Regional Government research is needed to determine the production capacity of Iraqi wheat varieties under drought stress and the potential for the maximization of the drought tolerance response. The soil moisture holding capacity of the intended growing medium was measured gravimetrically in pots with and without wheat plants and correlated with the soil capacitance measured using a TDR Theta Probe (Delta-T Devices). This was used to determine the available water content of the soil (AWC) and to control and manage the watering regimes during drought studies. The results of a study of the response of different cultivars of Iraqi wheat (Triticum aestivum L.) to watering regimes of 70% and 50% showed that drought stress had a significant effect on the biomass and yield traits especially tiller number and stem bundle weight compared to normal conditions. The highest significant difference was observed for cv. Tamooz 2 in comparison to Adana 99, but there was a little difference between cvs. Rizgary and Sham 6. The effect of the exogenous application of salicylic acid (SA) and molybdenum (Mo) on drought tolerance of cvs. Tamooz 2 and Adana 99, showed that Tamooz 2 had higher values for growth characteristics and higher yield potential when sprayed with a lower concentration of SA (1.44 mM) under well-watered conditions in comparison with Adana 99. The effect of spraying variety Tamooz 2 with SA at different growth stages indicated that biomass production and yield components (the number of spikes/pot, grain dry weight and average 1000 grain dry weight) significantly increased at both stem+flower as well as leaf+stem+flower sprayings for plants subjected to drought. Also, SA treatments at stem extension and flowering had a positive effect on the up-regulation of the drought response gene CBF/DREB under drought stress conditions. These findings indicate that agronomic treatments with exogenous applications of salicylic acid and molybdenum could help to reduce the effects of drought in the field.
APA, Harvard, Vancouver, ISO, and other styles
9

Djerbi, Soraya. "Cellulose synthases in Populus- identification, expression analyses and in vitro synthesis." Doctoral thesis, Stockholm, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-414.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Wurst, Zanna M. "Oestradiol upregulaton of vitamin D-inducible gene transcription /." Title page and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09SB/09sbw9688.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Gene upregulation"

1

Huang, Vera. "Endogenous miRNAa: miRNA-Mediated Gene Upregulation." In RNA Activation, 65–79. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4310-9_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Saito, Takako, San-e. Ishikawa, Minori Higashiyama, Tomoatsu Nakamura, Ikuyo Kusaka, Shoichiro Nagasaka, Sei Sasaki, and Toshikazu Saito. "Upregulation of Aquaporin-2 Gene Expression in Pathological State of Impaired Water Excretion in Glucocorticoid-Deficient Rats." In Molecular Biology and Physiology of Water and Solute Transport, 231–38. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1203-5_32.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

García-Arencibia, Moisés, Concepción García, Alexander Kurz, José A. Rodríguez-Navarro, Suzana Gispert-Sánchez, María A. Mena, Georg Auburger, Justo García Yébenes, and Javier Fernández-Ruiz. "Cannabinoid CB1 Receptors are Early DownRegulated Followed by a Further UpRegulation in the Basal Ganglia of Mice with Deletion of Specific Park Genes." In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 269–75. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_22.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

"Adhesion-Dependent Upregulation of Bacterial Genes." In Bacterial Adhesion to Animal Cells and Tissues, 143–46. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817800.ch9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Snell, Cameron, Kevin C. Gatter, Adrian L. Harris, and Francesco Pezzella. "Cancer and metabolism." In Oxford Textbook of Oncology, 119–24. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199656103.003.0013.

Full text
Abstract:
This chapter covers the relationship between cancer and metabolism. It discusses the role of angiogenesis and metabolic reprogramming in influencing tumour growth. The transcription factors that orchestrate the metabolic switch are discussed. The chapter presents an overview of the contribution of tumour suppressors to increased glycolysis. The metabolic changes that support uncontrolled proliferation such as lactate and pH levels, hypoxia, and reactive oxygen species are discussed. The chapter also covers the contribution of metabolic genes with oncogenic or tumour suppressor activity to metabolic transformation, the upregulation of lipid biosynthesis in cancer, and glycogen synthesis in cancer. The chapter concludes with a description of the potential strategies for targeting metabolic transformation.
APA, Harvard, Vancouver, ISO, and other styles
6

Snell, Cameron, Kevin C. Gatter, Adrian L. Harris, and Francesco Pezzella. "Cancer and metabolism." In Oxford Textbook of Oncology, 119–24. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199656103.003.0013_update_001.

Full text
Abstract:
This chapter covers the relationship between cancer and metabolism. It discusses the role of angiogenesis and metabolic reprogramming in influencing tumour growth. The transcription factors that orchestrate the metabolic switch are discussed. The chapter presents an overview of the contribution of tumour suppressors to increased glycolysis. The metabolic changes that support uncontrolled proliferation such as lactate and pH levels, hypoxia, and reactive oxygen species are discussed. The chapter also covers the contribution of metabolic genes with oncogenic or tumour suppressor activity to metabolic transformation, the upregulation of lipid biosynthesis in cancer, and glycogen synthesis in cancer. The chapter concludes with a description of the potential strategies for targeting metabolic transformation.
APA, Harvard, Vancouver, ISO, and other styles
7

Sousa, M. M., J. B. Amaral, A. Guimarães, and M. J. Saraiva. "Upregulation of the Extracellular Matrix Remodeling Genes, Biglycan, Neutrophil Gelatinase-Associated Lipocalin and Matrix Metalloproteinase-9 in Familial Amyloid Polyneuropathy." In Amyloid and Amyloidosis, 320–22. CRC Press, 2004. http://dx.doi.org/10.1201/9781420037494-113.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Saraiva, M., A. Guimarães, M. Sousa, and J. Amaral. "Upregulation of the Extracellular Matrix Remodeling Genes, Biglycan, Neutrophil Gelatinase-Associated Lipocalin and Matrix Metalloproteinase-9 in Familial Amyloid Polyneuropathy." In Amyloid and Amyloidosis, 320–22. CRC Press, 2004. http://dx.doi.org/10.1201/9781420037494.ch109.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Kundu, Debangana, Pratik Talukder, and Sarmistha Sen Raychaudhuri. "In Vitro Biosynthesis of Polyphenols in the Presence of Elicitors and Upregulation of Genes of the Phenylpropanoid Pathway in Plantago ovata." In Studies in Natural Products Chemistry, 299–344. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-444-64181-6.00008-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Gene upregulation"

1

Ohno, Shinichiro, Yoshihiro Sambu, Keiki Oikawa, Yoshitaka Naito, Yuichirou Harada, and Masahiko Kuroda. "Abstract 4433: Upregulation ofBLUtumor suppressor gene by miR-34a." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4433.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Singh, Pallavi. "Upregulation and cell specificity of C4 genes are derived from ancestral C3 gene regulatory networks." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.531611.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Kudo, Megumi, emiko Ogawa, Akane Haruna, Daisuke Kinose, yuma Hoshino, Shigeo Muro, toyohiro Hirai, and Michiaki Mishima. "Oxidative Stress Augmented IL-32 Gene Upregulation In Airway Epithelial Cells." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6595.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Hoey, David A., and Christopher R. Jacobs. "Oscillatory Fluid Flow Affects the Osteogenic Differentiation of Human Bone Marrow Stromal Cells in a Primary Cilium Dependent Manner." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53435.

Full text
Abstract:
Osteoporosis is a debilitating bone disease which occurs in part when bone marrow stromal cells (BMSCs) fail to produce sufficient numbers of osteoblasts to counteract bone resorption by osteoclasts. The majority of research to date has described chemically induced differentiation of BMSCs but a key regulator of stromal cell differentiation is physical loading. BMSCs experience both hydrostatic pressure and fluid flow within the marrow cavity and such modes of loading have been shown to significantly alter gene expression in vitro [1,2]. In particular, the effect of oscillatory fluid flow (OFF) induced shear stress results in the upregulation of osteogenic genes in preosteoblastic cells; however the effect of this mode of loading is not well characterized in human MSCs (hMSCs) [3].
APA, Harvard, Vancouver, ISO, and other styles
5

Ahmed, Sumaya, and Nasser Rizk. "The Expression of Bile Acid Receptor TGR5 in Adipose Tissue in Diet-Induced Obese Mice." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0212.

Full text
Abstract:
Bile acids are significant physiological factors for digestion, solubilization, absorption, toxic metabolites and xenobiotics. In addition, bile acids are responsible of signal transduction as well as metabolic regulation that activate several receptors such as farnesoid X receptor (FXR) and the membrane G-protein receptor 5 (TGR5). Activation of TGR5 by bile acids is associated with prevention of obesity as well as ameliorating the resistance to insulin via increasing energy expenditure. The objective of this research is to investigate TGR5 gene expression level in different fat depots including visceral or epididymal adipose tissue (eWAT), brown adipose tissue and inguinal adipose tissue (iWAT) and to study the response of TGR5 gene expression to the antiobesity treatment (SFN). Three groups of male CD1 mice were used in this study; lean group fed with SCD, DIO mice on HFD and DIO obese mice treated with anti-obesity treatment. Body weight (BW) and phenotype data were evaluated by weekly including blood samples for analysis of glucose, insulin, leptin, triglycerides (TG). Total RNA was extracted from different fat depots and RT-PCR profiler array technology was used to in order to assess the mRNA expression of TGR5 and leptin. There was significant downregulation of TGR5 gene expression level in obese (DIO) mice and remarkable upregulation of TGR5 gene expression after successful weight loss in DIO mice treated with SFN in time dependent manner at 1 weeks and 4 weeks of ip applications. In conclusion, obesity is associated with decrease in expression of TGR5 in different fat depots and treatment with anti-obesity drug (Sulforaphane) causes stepwise upregulation of TGR5 gene expression in epididymal white adipose tissue parallel stepwise decrease in body weight. Increase of expression of TGR5 in DIO mice in eWAT is accompanied by improvement in glucose homeostasis and insulin action.
APA, Harvard, Vancouver, ISO, and other styles
6

Al-Jaber, Hend Sultan, Layla Jadea Al-Mansoori, and Mohamed Aghar Elrayess. "The Role of GATA3 in Adipogenesis & Insulin Resistance." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0143.

Full text
Abstract:
Background: Impaired adipogenesis plays an important role in the development of obesityassociated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. In hyperglycemia, immune system is activated partially through upregulation of GATA3, causing exacerbation of the inflammatory state associated with obesity. GATA3 also plays a role as a gatekeeper of terminal adipocyte differentiation. Here we are examining the impact of GATA3 inhibition in adipose tissue on restoring adipogenesis, reversing insulin resistance and potentially lowering the risk of type 2 diabetes. Results: GATA-3 expression was higher in insulin resistant obese individuals compared to their insulin sensitive counterparts. Targeting GATA-3 with GATA-3 specific inhibitors reversed impaired adipogenesis and induced changes in the expression of a number insulin signaling-related genes, including up-regulation of insulin sensitivity-related gene and down-regulation of insulin resistance-related genes. Conclusion: GATA3 expression is higher in differentiating adipocytes from obese insulin resistant. Inhibiting GATA3 improves adipocytes differentiation and rescues insulin sensitivity in insulin resistant cells
APA, Harvard, Vancouver, ISO, and other styles
7

Allen, Joshua E., Gabriel Krigsfeld, Akshal S. Patel, Gen Sheng Wu, David T. Dicker, and Wafik S. El-Deiry. "Abstract 1935: Potent anti-tumor effects of TIC10 require Foxo3a and TRAIL gene upregulation." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1935.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Killian, Megan L., Barbara Zielinska, and Tammy L. Haut Donahue. "Role of IL-1 on Aggrecanase and COX-2 Gene Expression of Meniscal Explants Following Dynamic Compression." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19110.

Full text
Abstract:
The menisci within the knee likely respond to adverse loading conditions, leading to aggravated cartilage damage and fissuring [1]. Upregulation of catabolic molecules such as interleukin-1α (IL-1α), metalloproteinases (MMPs), aggrecanases (ADAMTS-4 and -5), and cyclooxygenase-2 (COX-2), as well as release of proteoglycans [2], have been shown in vitro for meniscal explants following dynamic loading [3]. A crucial event in matrix degradation is the loss of aggrecan, caused by the ADAMTS family [4]. In osteoarthritic cartilage, IL-1 has been shown to influence COX-2 activity, leading to increased synthesis of prostaglandin E2 and subsequent proteinase activity [5].
APA, Harvard, Vancouver, ISO, and other styles
9

Wismach, Marnie, Kai Xu, Ying Chen, Ruth Katz, Luc Girard, John D. Minna, Jack A. Roth, and Lin Ji. "Abstract 3921: Amplification of the TFAP2B gene and upregulation of its gene products promote human bronchial epithelial cell (HBEC) transformation and carcinogenesis." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3921.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Huang, Alice H., and Robert L. Mauck. "Repeated Dynamic Loading Modulates Cartilage Gene Expression but Does Not Improve Mechanical Properties of MSC-Laden Hydrogels." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204339.

Full text
Abstract:
Mesenchymal stem cells (MSCs) are a multi-potential cell type that can differentiate toward a variety of tissue-specific phenotypes, including cartilage. Given their chondrogenic potential, MSCs are a promising cell source for cartilage tissue engineering (TE). However, while MSCs readily undergo chondrogenesis in 3D culture and deposit a cartilage-like matrix, the mechanical properties of MSC-seeded constructs are greatly inferior to chondrocyte-seeded constructs similarly maintained [1]. To date, optimization strategies for enhancing functional MSC chondrogenesis, including increasing seeding density and transient application of growth factor, have shown limited success [3]. Using microarray analysis, we have recently demonstrated that mis-expression of certain genes, including lubricin, chondromodulin and RGD-CAP, a collagen associated protein, may underlie this disparity in mechanical function [2]. In this study, we examined dynamic compression as an alternative method to enhance MSC differentiation. Previous work using chondrocyte-based constructs have demonstrated that matrix biosynthesis and mechanical properties were improved with the application of cyclic compression [4]. Furthermore, upregulation of lubricin was observed when surface motion was applied to chondrocyte-seeded porous scaffolds [5]. While significant effort has gone toward optimizing loading parameters to direct tissue growth of chondrocyte-based constructs, few studies have examined the effects of mechanical stimulation on MSC-based constructs. Some have demonstrated positive effects on MSC chondrogenesis with application of compressive loading [6, 7], while others have shown that long-term loading may adversely affect the developing mechanical properties of MSC-seeded constructs [8]. In this study, we examined the effects of repeated dynamic compressive loading on MSC chondrogenesis and showed that mechanical properties and gene expression were modulated by this loading modality.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Gene upregulation' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography