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Journal articles on the topic 'Gene therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 November 2024

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1

Goyal, Anjana, Reena Doomra, Aayushi Garg, and Kruthiventi Hemalata. "CRISPR Gene Therapy in Dentistry." Asian Pacific Journal of Health Sciences 6, no. 2 (June 2019): 182–83. http://dx.doi.org/10.21276/apjhs.2019.6.2.26.

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2

Gawthorpe, Paula. "Gene Therapy Gene Therapy." Nursing Standard 17, no. 33 (April 30, 2003): 29. http://dx.doi.org/10.7748/ns2003.04.17.33.29.b25.

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3

M. Gordon, Erlinda, Joshua R. Ravicz, Sant P. Chawla, Christopher W. Szeto, Sant P. Chawla, Michael A. Morse, Frederick L. Hall, and Erlinda M. Gordon. "CCNG1 oncogene: a novel biomarker for cancer therapy /gene therapy." Cancer Research and Cellular Therapeutics 5, no. 4 (August 30, 2021): 01–09. http://dx.doi.org/10.31579/2640-1053/090.

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Background: Metastatic cancer is associated with an invariably fatal outcome. However, DeltaRex-G, a tumor-targeted retrovector encoding a gene-edited dominant-negative CCNG1 inhibitor gene, has induced long term (>10 years) survival of patients with chemo-resistant metastatic pancreatic adenocarcinoma, malignant peripheral nerve sheath tumor, osteosarcoma, B-cell lymphoma, and breast carcinoma. Objective: To evaluate the level of CCNG1 expression in tumors as a potential biomarker for CCNG1 (Cyclin G1-blocking) inhibitor therapy. Methods: CCNG1 RNA expression levels that were previously measured as part of whole genome molecular profiling of tumors (TCGA, N=9161), adjacent “tissues” (TCGA, N=678) and GTEx normal tissues (N=7187) across 22 organ sites were analyzed. Differential expression of CCNG1 and Ki-67 in primary (N= 9161) vs metastatic (N= 393) tumors were also compared in primary (N=103) vs. metastatic (N=367) skin cancers (i.e., melanoma). Statistical Analysis: To detect systematically differential expression of CCNG1 and Ki-67 expression between populations (e.g. tumor vs. normal), unpaired Student's t-tests were performed. Results: Enhanced CCNG1 RNA and Cyclin G1 protein expression were noted in tumors compared to normal analogous counterparts, and CCNG1 expression correlated significantly with that of Ki-67. Moreover, CCNG1 expression tended to be higher than that of Ki-67 in metastatic vs primary tumors. Conclusions: Taken together with the emerging Cyclin G1 / Cdk / Myc / Mdm2 / p53 Axis governing Cancer Stem Cell Competence, this supportive data indicates: (1) CCNG1 expression is frequently enhanced in tumors when compared to their normal analogous counterparts, (2) CCNG1 and Ki-67 expressions are higher in metastatic vs primary tumors, (3) CCNG1 expression is significantly correlated with that of Ki-67, and (4) CCNG1 may actually be a stronger prognostic marker of stem cell competence, chemo-refractoriness, and EMT/metastasis than Ki-67. Phase 2 studies are planned to identify patients most likely to respond favorably to CCNG1 inhibitor therapy.

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4

Sose, Mr Aadesh S., and Mr Pramod M. Bhosale. "A Review on Gene Therapy for Cancer." International Journal of Research Publication and Reviews 4, no. 4 (April 2023): 3058–63. http://dx.doi.org/10.55248/gengpi.4.423.36713.

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5

&NA;. "Gene therapy." Inpharma Weekly &NA;, no. 1161 (October 1998): 12. http://dx.doi.org/10.2165/00128413-199811610-00018.

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6

&NA;. "Gene therapy." Inpharma Weekly &NA;, no. 1184 (April 1999): 8. http://dx.doi.org/10.2165/00128413-199911840-00015.

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7

Peroutka, Christina, and Joann Bodurtha. "Gene Therapy." Pediatrics in Review 41, no. 11 (November 2020): 606–8. http://dx.doi.org/10.1542/pir.2019-0224.

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8

&NA;. "Gene therapy." Inpharma Weekly &NA;, no. 1120 (January 1998): 4. http://dx.doi.org/10.2165/00128413-199811200-00004.

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9

Whartenby, Katharine A., Aizen J. Marrogi, and Scott M. Freeman. "Gene Therapy." Drugs 50, no. 6 (December 1995): 951–58. http://dx.doi.org/10.2165/00003495-199550060-00003.

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10

Williamson, Robert. "Gene therapy." Australian Prescriber 20, no. 3 (July 1, 1997): 72–73. http://dx.doi.org/10.18773/austprescr.1997.062.

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11

Fibison, Wendy J. "GENE THERAPY." Nursing Clinics of North America 35, no. 3 (September 2000): 757–72. http://dx.doi.org/10.1016/s0029-6465(22)02515-4.

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12

Nerkar, A. G., and G. S. Chakraborthy. "Gene therapy." Current Trends in Pharmacy and Pharmaceutical Chemistry 3, no. 3 (July 15, 2021): 15–18. http://dx.doi.org/10.18231/j.ctppc.2021.005.

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Gene therapy is used to correct defective genes in order to cure a disease or help your body better fight disease. Gene therapy is the introduction, removal or change in genetic material specifically DNA or RNA into the cells of a patient to treat a specific disease. Disease is caused to mutation. Genes influence all from the color of our hair to immune system, but genes are not built correctly. Targets of the gene therapy causing diseases. Gene therapy uses section of DNACurrently gene therapy is being tested only for disease that have no. other cures. Interest area of this review covers introduction, history, DNA transfer, Types of gene therapy, working of therapy, techniques, Delivery system, strategies, technique challenges, risks, gene introduction site and clinical applications of gene therapy.

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13

&NA;. "Gene therapy." Drugs & Therapy Perspectives 7, no. 9 (May 1996): 6–8. http://dx.doi.org/10.2165/00042310-199607090-00002.

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14

High, Katherine A., and Maria G. Roncarolo. "Gene Therapy." New England Journal of Medicine 381, no. 5 (August 1, 2019): 455–64. http://dx.doi.org/10.1056/nejmra1706910.

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15

Steinberg, Gary K. "Gene Therapy." Neurosurgery 44, no. 2 (February 1, 1999): 253. http://dx.doi.org/10.1097/00006123-199902000-00002.

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16

Rutka, James T. "Gene Therapy." Neurosurgery 44, no. 2 (February 1, 1999): 253. http://dx.doi.org/10.1097/00006123-199902000-00003.

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17

Nemirovsky, Alexander, and Vladimir Zelman. "Gene Therapy." Neurosurgery 44, no. 2 (February 1, 1999): 253. http://dx.doi.org/10.1097/00006123-199902000-00004.

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18

&NA;. "Gene therapy." Reactions Weekly &NA;, no. 987 (February 2004): 9–10. http://dx.doi.org/10.2165/00128415-200409870-00023.

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19

Verma, Inder M. "Gene Therapy." Scientific American 263, no. 5 (November 1990): 68–84. http://dx.doi.org/10.1038/scientificamerican1190-68.

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20

Baum, BJ. "Gene therapy." Oral Diseases 20, no. 2 (December 26, 2013): 115–18. http://dx.doi.org/10.1111/odi.12211.

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21

Scheller, Erica L., Luis G. Villa-Diaz, and Paul H. Krebsbach. "Gene Therapy." Journal of Craniofacial Surgery 23, no. 1 (January 2012): 333–37. http://dx.doi.org/10.1097/scs.0b013e318241dc11.

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22

Drugan, Arie, Orlando J. Miller, and Mark I. Evans. "Gene Therapy." Fetal Diagnosis and Therapy 2, no. 4 (1987): 232–41. http://dx.doi.org/10.1159/000263322.

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23

Mavilio, Fulvio, and Claudio Bordignon. "Gene therapy." Nature 362, no. 6418 (March 1993): 284. http://dx.doi.org/10.1038/362284b0.

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24

Morris, Jonathan. "Gene Therapy." American Biology Teacher 75, no. 2 (February 1, 2013): 139. http://dx.doi.org/10.1525/abt.2013.75.2.14.

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25

Scully, Sean P. "Gene Therapy:." Clinical Orthopaedics and Related Research 379 (October 2000): S55—S58. http://dx.doi.org/10.1097/00003086-200010001-00007.

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26

Spallone, P. "Gene therapy." BMJ 305, no. 6848 (August 1, 1992): 315. http://dx.doi.org/10.1136/bmj.305.6848.315-b.

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27

Badiavas, Evangelos V., and Vincent Falanga. "Gene Therapy." Journal of Dermatology 28, no. 4 (April 2001): 175–92. http://dx.doi.org/10.1111/j.1346-8138.2001.tb00116.x.

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28

SHAPIRO, LARRY J. "Gene Therapy." Pediatric Research 33, no. 4 (1993): 321–22. http://dx.doi.org/10.1203/00006450-199333040-00002.

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29

STROHMAN, RICHARDC. "Gene therapy." Nature 355, no. 6362 (February 1992): 667. http://dx.doi.org/10.1038/355667c0.

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30

Trent, Ronald J. A. "Gene therapy." Heart, Lung and Circulation 9, no. 1 (May 2000): 43. http://dx.doi.org/10.1046/j.1444-2892.2000.0007b.x.

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31

Kay, M. A., D. Liu, and P. M. Hoogerbrugge. "Gene therapy." Proceedings of the National Academy of Sciences 94, no. 24 (November 25, 1997): 12744–46. http://dx.doi.org/10.1073/pnas.94.24.12744.

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32

Beutler, Ernest. "Gene therapy." Biology of Blood and Marrow Transplantation 5, no. 5 (October 1999): 273–76. http://dx.doi.org/10.1016/s1083-8791(99)70001-7.

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33

Mhashilkar, Abner, Sunil Chada, Jack A. Roth, and Rajagopal Ramesh. "Gene therapy." Biotechnology Advances 19, no. 4 (July 2001): 279–97. http://dx.doi.org/10.1016/s0734-9750(01)00063-5.

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34

Brody, Herb. "Gene therapy." Nature 564, no. 7735 (December 2018): S5. http://dx.doi.org/10.1038/d41586-018-07639-9.

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35

Kmiec, Eric. "Gene Therapy." American Scientist 87, no. 3 (1999): 240. http://dx.doi.org/10.1511/1999.3.240.

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36

Yaron, Yuval, Ralph L. Kramer, Mark P. Johnson, and Mark I. Evans. "GENE THERAPY." Obstetrics and Gynecology Clinics of North America 24, no. 1 (March 1997): 179–99. http://dx.doi.org/10.1016/s0889-8545(05)70296-5.

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37

Birnstiel, Max L. "Gene therapy." European Review 4, no. 04 (October 1996): 335. http://dx.doi.org/10.1017/s1062798700002118.

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38

Trempe, James P. "Gene therapy." Biochemical Education 25, no. 4 (October 1997): 246–47. http://dx.doi.org/10.1016/s0307-4412(97)87549-8.

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39

Baird, P. A. "GENE THERAPY." Lancet 333, no. 8643 (April 1989): 902. http://dx.doi.org/10.1016/s0140-6736(89)92896-1.

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40

Bauer, Daniel E., and Donald B. Kohn. "Gene Therapy." Hematology/Oncology Clinics of North America 31, no. 5 (October 2017): i. http://dx.doi.org/10.1016/s0889-8588(17)30117-x.

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41

Tzeng, Edith, Larry L. Shears, Michael T. Lotze, and Timothy R. Billiar. "Gene therapy." Current Problems in Surgery 33, no. 12 (December 1996): 961–1041. http://dx.doi.org/10.1016/s0011-3840(05)80020-6.

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42

Steffin, David H. M., Emily M. Hsieh, and Rayne H. Rouce. "Gene Therapy." Advances in Pediatrics 66 (August 2019): 37–54. http://dx.doi.org/10.1016/j.yapd.2019.04.001.

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43

Vile, Richard G. "Gene therapy." Current Biology 8, no. 3 (January 1998): R73—R75. http://dx.doi.org/10.1016/s0960-9822(98)70049-1.

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44

Vogelzang, Robert L. "Gene Therapy." Journal of Vascular and Interventional Radiology 11, no. 2 (February 2000): 59. http://dx.doi.org/10.1016/s1051-0443(00)70033-9.

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45

Sharp, David. "Gene therapy." Lancet 337, no. 8752 (May 1991): 1277–78. http://dx.doi.org/10.1016/0140-6736(91)92938-x.

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46

Wood, E. J. "Gene therapy." Biochemical Education 24, no. 3 (July 1996): 181. http://dx.doi.org/10.1016/0307-4412(96)82519-2.

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47

Geddes, Duncan M. "Gene therapy." Lancet 348, no. 9038 (November 1996): 1367–68. http://dx.doi.org/10.1016/s0140-6736(05)65410-4.

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48

TAKAKU, Fumimaro. "Gene Therapy." Internal Medicine 32, no. 4 (1993): 273. http://dx.doi.org/10.2169/internalmedicine.32.273.

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49

Bhattacharya, Alok. "Gene Therapy." Current Science 114, no. 03 (February 10, 2018): 432. http://dx.doi.org/10.18520/cs/v114/i03/432-433.

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50

Heslop, Helen. "Gene therapy." Cytotherapy 5, no. 3 (2003): 189. http://dx.doi.org/10.1080/14653240310001280.

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