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1
R, Crute I., Holub E. B, Burdon J. J, and British Society for Plant Pathology., eds. The gene-for-gene relationship in plant-parasite interactions. Wallington, UK: CAB International, 1997.
2
Håkansssson, Gunilla. Nuclear-mitochondrial interactions and its relevance for male sterility in Nicotiana: Analysis of mitochondrial genome organization, gene expression and respiration in male-fertile and alloplasmic male-sterile materials. Uppsala, Sweden: Swedish University of Agricultural Sciences, Dept. of Plant Breeding, 1992.
3
Sasaki, Joni Y., Jessica LeClair, Alexandria West, and Heejung S. Kim. The Gene–Culture Interaction Framework and Implications for Health. Edited by Joan Y. Chiao, Shu-Chen Li, Rebecca Seligman, and Robert Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199357376.013.20.
4
Razzoli, Maria, Alessandro Bartolomucci, and Valeria Carola. Gene-by-Environment Mouse Models for Mood Disorders. Edited by Turhan Canli. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199753888.013.013.
Abstract:
Much of the impact of genes on mood disorders likely depends on interactions between genes and the environment. Recent studies demonstrating an interaction between specific genes and life stressful events (early and/or adult) in the modulation of several mood disorders (e.g., serotonin transporter and brain-derived neurotrophic factor genes) have compelled researchers to incorporate information about adverse environmental experiences into the study of genetic risk factors; these same gene-by-environment (G×E) interactions have been identified in mouse models. Notably, G×E not yet described in humans (e.g., serotonin 1A receptor gene) have been uncovered, providing helpful indications to discover similar interactions in humans. Accurate knowledge of the modality of expression of gene-by-stress interaction may help design prevention protocols aimed at identifying susceptibility to mood disorders on the basis of genetic predisposition and exposure to environmental stressful conditions, thus providing patients with appropriate pharmacological and psychological support.
5
He, Zihuai, Michael Windle, James Y. Dai, and Caroline Y. Doyle. Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes. MIT Press, 2016.
6
Windle, Michael, Charles Kooperberg, James Y. Dai, Li Yang Hsu, and Jung-Ying Tzeng. Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes. MIT Press, 2016.
7
Klengel, Torsten, Lauren A. M. Lebois, Sheila Gaynor, and Guia Guffanti. Genetics and Gene–Environment Interaction. Edited by Frederick J. Stoddard, David M. Benedek, Mohammed R. Milad, and Robert J. Ursano. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190457136.003.0017.
Abstract:
Trauma and stress-related disorders make an excellent case for gene-environment interactions because although exposure to trauma and stress is a well-established risk factors toward their development, such factors alone are not sufficient to explain etiopathogenesis. Exposure to traumatic events is a prerequisite of posttraumatic stress disorder (PTSD) diagnosis, but the majority of individuals who are exposed to even a severe traumatic event do not develop PTSD. Why some individuals are vulnerable and others are resilient remains an open question. While genetic factors may play a significant role, it is conceivable that the complex interplay between genetic and environmental factors contribute to the observed interindividual variability.
8
Silvers, W. K. Coat Colors of Mice: A Model for Mammalian Gene Action and Interaction. Springer London, Limited, 2012.
9
Han, Shihui. Gene-culture interaction on human behavior and the brain. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780198743194.003.0007.
Abstract:
Chapter 7 reviews empirical findings that allow consideration of biological and environmental influences on human behavior from an evolutionary perspective (e.g., gene-culture coevolution) and from a perspective of individual development (e.g., gene-culture interaction). It also reviews imaging genetic studies that link genes with brain functional organization. It introduces a cultural neuroscience paradigm for investigating genetic influences on the coupling of brain activity and culture by presenting two studies that examined how serotonin transporter functional polymorphism and oxytocin receptor gene moderate the association between interdependence and brain activities involved in self-reflection and empathy. These studies illustrate a new approach to understanding the manner with which culture interacts with gene to shape human brain activity.
10
Silvers, W. K. The Coat Colors of Mice: A Model For Mammalian Gene Action And Interaction. Springer, 2011.
11
Locus control region activity by 5'HS3 requires a functional interaction with [beta]-globin gene regulatory elements: Identification of effective [beta]/[gamma]-globin minigenes for gene therapy of the [beta]-chain hemoglobinopathies. Ottawa: National Library of Canada, 2000.
12
Haiman, Christopher, and David J. Hunter. Genetic Epidemiology of Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676827.003.0004.
Abstract:
This chapter explores the genetic epidemiology of cancer: the identification and quantification of inherited genetic factors, and their potential interaction with the environment, in the etiology of cancer in human populations. It also describes the techniques used to identify genetic variants that contribute to cancer susceptibility. It describes the older research methods for identifying the chromosomal localization of high-risk predisposing genes, such as linkage analysis within pedigrees and allele-sharing methods, as it is important to understand the foundations of the field. It also reviews the epidemiologic study designs that can be helpful in identifying low-risk alleles in candidate gene and genome-wide association studies, as well as gene–environment interactions. Finally, it describes some of the genotyping and sequencing platforms commonly employed for high-throughput genome analysis, and the concept of Mendelian randomization and how it may be useful in the study of biomarkers and environmental causes of cancer.
13
Ernst, Wagner, Dexi Liu, and Leaf Huang. Nonviral Vectors for Gene Therapy: Lipid- and Polymer-Based Gene Transfer. Elsevier Science & Technology Books, 2014.
14
(Editor), Mien-Chie Hung, Leaf Huang (Editor), and Ernst Wagner (Editor), eds. Nonviral Vectors for Gene Therapy. Academic Press, 1999.
15
Ernst, Wagner, Mien-Chie Hung, and Leaf Huang. Nonviral Vectors for Gene Therapy. Elsevier Science & Technology Books, 1999.
16
Stoddard, Frederick J., and Robert L. Sheridan. Wound Healing and Depression. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0009.
Abstract:
Depression and wound healing are bidirectional processes for adults and children consistent with the conception of depression as systemic. This systemic interaction is similar to the “bidirectional impact of mood disorder on risk for development, progression, treatment, and outcomes of medical illness” generally. And, evidence is growing that the bidirectional impact of mood disorder may be true for injuries and for trauma surgery. Animal models have provided some support that treatment of depression may improve wound healing. An established biological model for a mechanism delaying wound healing is increased cortisol secretion secondary to depression and/or stress, and impaired immune response, in addition or together with the other factors such as genetic or epigenetic risk for depression. Cellular models relate both to wound healing and to depression include cytokines, the inflammatory response (Miller et al, 2008), and cellular aging (Telgenhoff and Shroot, 2005) reflected in shorter leukocyte telomere length (LTL) (Verhoeven et al, 2016). Another model of stress impacting wound healing investigated genetic correlates—immediate early gene expression or IEG from the medial prefrontal cortex, and locomotion, in isolation-reared juvenile rats. Levine et al (2008) compared isolation reared to group reared samples, and found that, immediate gene expression in the medial prefrontal cortex (mPFC) was reduced, and behavioral hyperactivity increased, in juvenile rats with 20% burn injuries. Wound healing in the isolation reared rats was significantly impaired. They concluded that these results provide candidates for behavioral biomarkers of isolation rearing during physical injury, i.e. reduced immediate mPFC gene expression and hyperactivity. They suggested that a biomarker such as IEGs might aid in demarcating patients with resilient and adaptive responses to physical illness from those with maladaptive responses
17
Dweck, Carol S. Social Development. Edited by Philip David Zelazo. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199958474.013.0008.
Abstract:
This chapter describes new theories, concepts, and methods that are being brought to bear on the central questions of social development, and it highlights the unprecedented interdisciplinary nature of current research in social development. Topics include the foundations of “social-ness” and its role in making humans unique; new findings on gene–environment and temperament–environment interactions and their role in the emergence of important social outcomes; ways in which socialization experiences are carried forward in children’s mental representations and physiological changes; the impact of different agents of socialization, such as parents, peers, and media; the mutual influence of cognitive and social development, and the ways in which social-cognitive interventions can boost intellectual performance; and the burgeoning area of intergroup perception and interaction. Throughout I discuss the implications of recent discoveries for interventions, and the ways in which interventions both test theories and speak to the plasticity of developing systems.
18
Sousek, Alexandra, and Mehdi Tafti. The genetics of sleep. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0005.
Abstract:
Although there is strong evidence for a genetic contribution to inter-individual variations in sleep, the underlying factors and their interaction remain largely elusive. Much effort has been expended in studying genetic variations contributing to circadian and sleep phenotypes, the individual pattern of the human sleep EEG, reactions to sleep loss, and the pathophysiology of sleep-related disorders. Certain sleep-related diseases may be caused by single genes, while the etiology of others seems to be variable and complex. This is especially the case when the immune system is involved. This chapter reports on twin and familial studies, genetic variations and mutations affecting neurotransmitters and other signaling pathways and thereby affecting sleep, and impacts of gene expression processes and the immune system on sleep. Although much knowledge has been gained, further research is needed to elucidate the all-embracing mechanisms and their interactions that regulate sleep.
19
Kritsky, Gene, ed. A Cultural History of Insects In Antiquity. Bloomsbury Publishing Plc, 2024. http://dx.doi.org/10.5040/9781474203807.
Abstract:
A CULTURAL HISTORY OF INSECTS IN ANTIQUITY A Cultural History of Insects covers the period from 1000 BCE to 500 CE. As different cultures expanded so did their interactions with insects, largely seen as vectors of disease and as agricultural and bodily pests. However, as knowledge of insects grew, insect products were developed, notably honey or beeswax as used in food, preservation, medicine, and religious ritual. Insects were feared but were also invested with great power, even sanctity. The jewelry of ancient Egypt, Greece, and Rome fashioned insects into symbols of the beauty of nature, whilst literary and sacred texts transformed insects into metaphors for fertility and immortality. The 6 volume set of the Cultural History of Insects presents the first comprehensive history from antiquity to today of all forms and aspects of human-insect interaction. The themes covered in each volume are insect knowledge; insects and disease; insects and food; insect products; insects in mythology and religion; insects as symbols; insects in literature and language; and insects in art. The Cultural Histories Series A Cultural History of Insects is part of The Cultural Histories Series. Titles are available as hardcover sets for libraries needing just one subject or preferring a tangible reference for their shelves or as part of a fully-searchable digital library. The digital product is available to institutions by annual subscription or on perpetual access via www.bloomsburyculturalhistory.com. Individual volumes for academics and researchers interested in specific historical periods are also available in print or digitally via www.bloomsburycollections.com. Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA. Volume 1 in the Cultural History of Insects set. General Editor: Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA.
20
Dyer, Paul S., Carol A. Munro, and Rosie E. Bradshaw. Fungal genetics. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0005.
Abstract:
Fungi have been long used as model organisms to investigate genetic and cellular processes. An overview is provided of how fungi function at a genetic level, including ploidy, gene structure, and gene flow by sexual and asexual processes. The tools used to study fungal genetics are then described, such techniques having widespread applications in medical mycology research. Classical genetic analysis includes the use of gene mapping by sexual crossing and tetrad analysis, and forward genetic experimentation based on mutagenesis, for which various mutant screening approaches are described. Molecular genetic analysis includes gene manipulation by transformation; different methods for gene knockout and targeting, and their application for forward and reverse genetic approaches, are outlined. Finally, molecular genetic methods used to study gene expression and function are reviewed, including use of inducible or constitutive overexpression, real-time PCR, cellular localization of gene products by fluorescent tagging, and detection of protein–protein interactions.
21
Stanworth, Simon, and Stuart McKechnie. Pathophysiology of disordered coagulation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0269.
Abstract:
Imbalances in the regulation of haemostasis may manifest as bleeding (depletion of pro-coagulant factors) or thrombosis (deficiency of anti-coagulants). Disordered haemostasis is common in critically-ill patients and may result from infection, trauma, haemorrhage, inflammation, organ dysfunction (notably renal and liver dysfunction), or drug therapy. Complex patterns of coagulopathy where both bleeding and prothrombotic tendencies co-exist are well recognized in critical illness. The limitations of standard laboratory coagulation tests to predict bleeding risk, including activated partial thromboplastin time and prothrombin time, are well recognized. These assays were developed for diagnosis of inherited bleeding disorders or for monitoring of anticoagulant therapy. This has led to increased interest in global haemostatic tests, such as viscoelastic and thrombin generation tests. Thromboembolism is an important cause of morbidity and mortality in critically-ill patients. While inherited causes of bleeding appear to be often related to single gene abnormalities, thrombotic tendencies appear to reflect more complex interactions between inherited and acquired factors. Many interactions exist between coagulation pathways and inflammation. Systemic inflammation triggers widespread activation of coagulation, with pro-inflammatory cytokines activating pro-coagulant pathways and downregulating anticoagulant pathways. A net result of this interaction between inflammatory and coagulation pathways in sepsis is thrombin generation, intravascular fibrin deposition and a consumptive coagulopathy.
22
Paris, Joel. The Relationship Between Childhood Adversity and Borderline Personality Disorder. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199997510.003.0005.
Abstract:
Borderline personality disorder (BPD) is often associated with adverse events in childhood. However, early adversity does not necessarily lead to BPD, and not all BPD patients have experienced childhood adversity. The key to understanding this relationship is gene-environment interaction. Children who are vulnerable by temperament are more severely affected by adverse events. This “double hit” is a risk for developing a personality disorder. The missing piece in research on adversity and BPD is longitudinal data. This could involve research in community samples, but the frequency of BPD as an outcome is not high enough to make that strategy effective. Instead, a high-risk strategy is called for, in which children identified as suffering from abuse and neglect are followed well into adulthood. These investigations will need to be multivariate and to take temperament into account.
23
Lelièvre, Sophie A., Rabih Shakib Talhouk, Victoria Seewaldt, Mary Beth Terry, and Martine Marie Bellanger, eds. Perspectives in Primary Prevention Research for Breast Cancer: A Focus on Gene—Environment Interactions. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88966-698-0.
24
Franke, Barbara, and Jan K. Buitelaar. Gene–environment interactions. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198739258.003.0005.
Abstract:
ADHD is highly heritable, but environmental factors also play significant roles in disease aetiology and outcome. Genetic and environmental influences are likely to show different types of interplay, with gene–environment interactions (G×E) playing a part. Different models of G×E exist, with the most frequently investigated in ADHD up to the present being the diathesis–stress and differential susceptibility models. The most frequently studied have been monoaminergic genes, often based on a single genetic variant. Only a single genome-wide study has been reported thus far. Environmental factors investigated include prenatal and postnatal risk factors for ADHD, in particular prenatal exposure to smoking or alcohol and aspects of parenting.
25
Ernst, Wagner, Dexi Liu, and Leaf Huang. Nonviral Vectors for Gene Therapy: Physical Methods and Medical Translation. Elsevier Science & Technology Books, 2015.
26
Kritsky, Gene, ed. A Cultural History of Insects In the Medieval Age. Bloomsbury Publishing Plc, 2024. http://dx.doi.org/10.5040/9781474203838.
Abstract:
A CULTURAL HISTORY OF INSECTS IN THE MEDIEVAL AGE A Cultural History of Insects in the Medieval Age covers the period from 500 to 1300, a time when the uses and value of insect products greatly increased. Silk, in particular, created economies and led to increased global trade; trade which, in turn, expanded the scope of insect-borne disease. The explosion in writing in the Middle Ages relied on inks, dyes, and waxes actively produced by insects or extracted from their crushed bodies. More visibly, insects began to teem across the pages of illuminated manuscripts, becoming symbols of divine order, earthly corruption, and ephemeral beauty. The 6 volume set of the Cultural History of Insects presents the first comprehensive history from antiquity to today of all forms and aspects of human-insect interaction. The themes covered in each volume are insect knowledge; insects and disease; insects and food; insect products; insects in mythology and religion; insects as symbols; insects in literature and language; and insects in art. The Cultural Histories Series A Cultural History of Insects is part of The Cultural Histories Series. Titles are available as hardcover sets for libraries needing just one subject or preferring a tangible reference for their shelves or as part of a fully-searchable digital library. The digital product is available to institutions by annual subscription or on perpetual access via www.bloomsburyculturalhistory.com. Individual volumes for academics and researchers interested in specific historical periods are also available in print or digitally via www.bloomsburycollections.com. Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA. Volume 2 in the Cultural History of Insects set. General Editor: Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA.
27
Samuels, Jack, Marco A. Grados, Elizabeth Planalp, and O. Joseph Bienvenu. Genetic Understanding of OCD and Spectrum Disorders. Edited by Gail Steketee. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195376210.013.0025.
Abstract:
This chapter reviews the evidence for the genetic etiology of OCD and spectrum conditions. A genetic basis is supported by the familial aggregation of OCD; evidence for involvement of genes of major effect in segregation analyses; and higher concordance for OCD in identical than non-identical twins. Recent studies also support linkage of OCD to specific chromosomal regions and association of OCD with specific genetic polymorphisms. However, specific genes causing OCD have not yet been firmly established. The search for genes is complicated by the clinical and etiologic heterogeneity of OCD, as well as the possibility of gene–gene and gene–environmental interactions. Despite this complexity, developments in molecular and statistical genetics, and further refinement of the phenotype hold promise for further deepening our genetic understanding of OCD and spectrum disorders in the coming decade.
28
Knaggs, Roger D. The molecular structure of the μ-opioid receptor. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0038.
Abstract:
The landmark paper discussed in this chapter describes the crystal structure of the μ-opioid receptor (also known as MOP-1). Opioids are some of the oldest known drugs and have been used for over 4,000 years; however, in addition to having beneficial analgesic effects, they are associated with a myriad of side effects that can minimize their use. Although the gene sequences of the opioid receptors were determined in the 1990s it has taken much longer to translate this into visualizing their three-dimensional structure. The μ-opioid receptor consists of seven transmembrane α-helices that are connected by three extracellular loops and three intracellular loops, with a wide open binding pocket which offers many potential ligand interaction sites, and evidence of dimerization. Understanding the crystal structure of the μ-opioid receptor in much more detail aids explanation of the molecular determinants of ligand recognition and selectivity and will be of use in designing novel opioids with improved efficacy and fewer side effects.
29
Kleinman, Ronald E., and Frank R. Greer, eds. Pediatric Nutrition (Sponsored Member Benefit). 7th ed. American Academy of Pediatrics, 2013. http://dx.doi.org/10.1542/9781581108606.
Abstract:
The new 7th edition provides the latest information about nutrient metabolism and nutrition to support the normal development and health of infants and children who are well, those born with congenital anomalies or disorders of metabolism, and those with acute and chronic illnesses. Contents include: - The latest evidence-based guidelines on feeding healthy infants and children - Current policies and practice recommendations from the AAP Committee on Nutrition - Several new chapters and appendices have been added, including chapters on school and daycare nutrition; gene and nutrient interaction; and metabolic programming. - Recent advances and developments on topics that arise frequently in pediatric practice: breastfeeding, fast foods, vegetarian diets, persistent newborn diarrhea, preterm infant nutrition needs, chronic obesity, vitamin supplementation, and more - Appendices of more than 50 tables including dietary allowances, energy requirements, composition of human milk and infant formulas, MyPlate, and more - More than 20 growth charts for very low and low birth weights; full-term infants, children, and adolescents; down syndrome; and more - Updated listings of resources for you and your patients, including printed materials, government agencies and Web sites
30
Stallings, Michael C., Ian R. Gizer, and Kelly C. Young-Wolff. Genetic Epidemiology and Molecular Genetics. Edited by Kenneth J. Sher. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199381678.013.002.
Abstract:
The tools of genetic epidemiology—family, adoption, and twin studies—show convincingly that substance use behavior and substance use disorders are influenced by both genetic and familial and extrafamilial environmental factors. Environmental factors appear to play a more influential role in the early stages of substance use, whereas genetic factors become more important in the development of problem use and substance use disorder. Moreover, some genetic effects are likely conditional on conducive environments; research employing both behavior genetic approaches and measured genes point to important gene–environment interactions that promote substance use and dependence. Consequently, a full understanding of the addiction process requires investigating substance use behavior within its comorbid context. The identification of specific genetic mechanisms underlying these heritable influences is elusive. These findings have prompted the development of new strategies for testing the joint effect of multiple genetic variants in gene-based or gene pathway analyses.
31
Raychaudhuri, Soumya. Computational Text Analysis. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780198567400.001.0001.
Abstract:
This book brings together the two disparate worlds of computational text analysis and biology and presents some of the latest methods and applications to proteomics, sequence analysis and gene expression data. Modern genomics generates large and comprehensive data sets but their interpretation requires an understanding of a vast number of genes, their complex functions, and interactions. Keeping up with the literature on a single gene is a challenge itself-for thousands of genes it is simply impossible. Here, Soumya Raychaudhuri presents the techniques and algorithms needed to access and utilize the vast scientific text, i.e. methods that automatically "read" the literature on all the genes. Including background chapters on the necessary biology, statistics and genomics, in addition to practical examples of interpreting many different types of modern experiments, this book is ideal for students and researchers in computational biology, bioinformatics, genomics, statistics and computer science.
32
Yang, Jin, Pei Han, Wei Li, and Ching-Pin Chang. Epigenetics and post-transcriptional regulation of cardiovascular development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0032.
Abstract:
Cardiac organogenesis requires the control of gene expression at distinct developmental windows in order to organize morphogenetic steps in the correct sequence for heart development. This is facilitated by concerted regulation at three levels: chromatin, transcription, and post-transcriptional modifications. Epigenetic regulation at the chromatin level changes the chromatin scaffold of DNA to regulate accessibility of the DNA sequence to transcription factors for genetic activation or repression. At the genome, long non-coding RNAs work with epigenetic factors to alter the chromatin scaffold or form DNA-RNA complexes at specific genomic loci to control the transcription of genetic information. After RNA transcription, the expression of genetic information can be further modified by microRNAs. Each layer of gene regulation requires the participation of many factors, with their combinatorial interactions providing variations of genetic expression at distinct pathophysiological phases of the heart. The major functions of chromatin remodellers and non-coding RNAs are discussed.
33
Ayers, Joseph. Biohybrid robots are synthetic biology systems. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199674923.003.0051.
Abstract:
This chapter describes how synthetic biology and organic electronics can integrate neurobiology and robotics to form a basis for biohybrid robots and synthetic neuroethology. Biomimetic robots capture the performance advantages of animal models by mimicking the behavioral control schemes evolved in nature, based on modularized devices that capture the biomechanics and control principles of the nervous system. However, current robots are blind to chemical senses, difficult to miniaturize, and require chemical batteries. These obstacles can be overcome by integration of living engineered cells. Synthetic biology seeks to build devices and systems from fungible gene parts (gene systems coding different proteins) integrated into a chassis (induced pluripotent eukaryotic cells, yeast, or bacteria) to produce devices with properties not found in nature. Biohybrid robots are examples of such systems (interacting sets of devices). A nascent literature describes genes that can mediate organ levels of organization. Such capabilities, applied to biohybrid systems, portend truly biological robots guided, controlled, and actuated solely by life processes.
34
Lehnert, Matthew S., ed. A Cultural History of Insects In The Age of Enlightenment. Bloomsbury Publishing Plc, 2024. http://dx.doi.org/10.5040/9781474203814.
Abstract:
A CULTURAL HISTORY OF INSECTS IN THE AGE OF ENLIGHTENMENT A Cultural History of Insects in the Age of Enlightenment covers the period from 1600 to 1820, a time of global exploration, the discovery of species, and advances in scientific technologies and methods. The natural sciences were increasingly shaped by what could be seen, observed, and classified. This new, Enlightenment approach to knowledge was greatly facilitated by enormous advances in microscopy. Enlightenment entomologists used miscrosopes to examine previously invisible bodies and worlds, illuminating insect metamorphosis and establishing the field of insect morphology. The 6 volume set of the Cultural History of Insects presents the first comprehensive history from antiquity to today of all forms and aspects of human-insect interaction. The themes covered in each volume are insect knowledge; insects and disease; insects and food; insect products; insects in mythology and religion; insects as symbols; insects in literature and language; and insects in art. The Cultural Histories Series A Cultural History of Insects is part of The Cultural Histories Series. Titles are available as hardcover sets for libraries needing just one subject or preferring a tangible reference for their shelves or as part of a fully-searchable digital library. The digital product is available to institutions by annual subscription or on perpetual access via www.bloomsburyculturalhistory.com. Individual volumes for academics and researchers interested in specific historical periods are also available in print or digitally via www.bloomsburycollections.com. Matthew S. Lehnert is Associate Professor of Biology at Kent State University, USA. Volume 4 in the Cultural History of Insects set. General Editor: Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA.
35
Morse, Stephen J. Genetics and Criminal Justice. Edited by Turhan Canli. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199753888.013.008.
Abstract:
This essay addresses the relevance of genetic data, including gene-by-environment interactions, to criminal responsibility and sentencing. After describing the criminal law’s implicit psychology and criteria for responsibility, it considers the present and future contributions genetics may make. It suggests that, at present, genetics should not play a large role in the adjudication of individual cases unless it translates directly into the law’s folk psychological criteria for responsibility, which it seldom does. Future discoveries may increase the usefulness of genetics to rational adjudication, however. The role of genetics at sentencing may be somewhat more promising, especially concerning the prediction of future behavior.
36
Thun, Michael, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld, eds. Cancer Epidemiology and Prevention. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.001.0001.
Abstract:
Since its initial publication in 1982, Cancer Epidemiology and Prevention has served as the premier reference work for both students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides an updated and comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. In this edition, special attention has been paid to molecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis.
37
Anelli, Carol M., and Susan W. Fisher. A Cultural History of Insects In The Age Of Industry. Bloomsbury Publishing Plc, 2024. http://dx.doi.org/10.5040/9781474203821.
Abstract:
A CULTURAL HISTORY OF INSECTS IN THE AGE OF INDUSTRY A Cultural History of Insects in the Age of Industry covers the period from 1820 to 1920, a time of great technological innovation and intensified trade. As urban populations spread so did pollution, squalor, and disease – and so did education and scientific knowledge. The expeditions of nineteenth century naturalists such as Charles Darwin and Alfred Russel Wallace fed the natural history collections of museums. At the same time, with the formation of new scientific groups and societies, professional entomology emerged as a specific branch of science. Knowledge of insect diversity accelerated whilst the increasing demands on agricultural production foregrounded the work of entomologists on pest control. The 6 volume set of the Cultural History of Insects presents the first comprehensive history from antiquity to today of all forms and aspects of human-insect interaction. The themes covered in each volume are insect knowledge; insects and disease; insects and food; insect products; insects in mythology and religion; insects as symbols; insects in literature and language; and insects in art. The Cultural Histories Series A Cultural History of Insects is part of The Cultural Histories Series. Titles are available as hardcover sets for libraries needing just one subject or preferring a tangible reference for their shelves or as part of a fully-searchable digital library. The digital product is available to institutions by annual subscription or on perpetual access via www.bloomsburyculturalhistory.com. Individual volumes for academics and researchers interested in specific historical periods are also available in print or digitally via www.bloomsburycollections.com. Carol Anelli is Professor and Susan Fisher is Professor Emerita, both in the Dept of Entomology at The Ohio State University, USA. Volume 5 in the Cultural History of Insects set. General Editor: Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA.
38
Smith, Sherilyn G. F., ed. A Cultural History of Insects In the Renaissance. Bloomsbury Publishing Plc, 2024. http://dx.doi.org/10.5040/9781474203852.
Abstract:
A CULTURAL HISTORY OF INSECTS IN THE RENAISSANCE A Cultural History of Insects in the Renaissance covers the period from 1300 to 1600, examining the profound impact of insects on the flowering of culture. In the early part of this period, the unprecedented number of deaths caused by the Plague – spread in part by fleas – encouraged the later rise of a middle class. Meanwhile, much of the wealth which funded Renaissance politics and patronage came from trade in honey, silk, and insect dyes, notably cochineal, one of the most valuable exports from the New World. And, as perceptions of humans and the natural world changed, interest in insects shifted from the symbolic to the scientific. The 6 volume set of the Cultural History of Insects presents the first comprehensive history from antiquity to today of all forms and aspects of human-insect interaction. The themes covered in each volume are insect knowledge; insects and disease; insects and food; insect products; insects in mythology and religion; insects as symbols; insects in literature and language; and insects in art. The Cultural Histories Series A Cultural History of Insects is part of The Cultural Histories Series. Titles are available as hardcover sets for libraries needing just one subject or preferring a tangible reference for their shelves or as part of a fully-searchable digital library. The digital product is available to institutions by annual subscription or on perpetual access via www.bloomsburyculturalhistory.com. Individual volumes for academics and researchers interested in specific historical periods are also available in print or digitally via www.bloomsburycollections.com. Sherilyn Smith is Associate Professor of Biology at Le Moyne College, USA. Volume 3 in the Cultural History of Insects set. General Editor: Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA.
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Peterson, Robert K. D., ed. A Cultural History of Insects In The Modern Age. Bloomsbury Publishing Plc, 2024. http://dx.doi.org/10.5040/9781474203845.
Abstract:
A CULTURAL HISTORY OF INSECTS IN THE MODERN AGE A Cultural History of Insects in the Modern Age covers the period from 1920 to the present, a time of tremendous scientific advances in our understanding of insects and their place in the natural world. The age ushered in an optimism fueled by the power of science and technology to improve the human condition and included stunning achievements in managing insect pests in the first half of the century. Today, although insects are recognised as cultural symbols of natural harmony and as bellwethers of ecological damage, our irrational fears continue, transforming insects into metaphors of invasion, alienation, and decay across literature, art, music, film, and political rhetoric. The 6 volume set of the Cultural History of Insects presents the first comprehensive history from antiquity to today of all forms and aspects of human-insect interaction. The themes covered in each volume are insect knowledge; insects and disease; insects and food; insect products; insects in mythology and religion; insects as symbols; insects in literature and language; and insects in art. The Cultural Histories Series A Cultural History of Insects is part of The Cultural Histories Series. Titles are available as hardcover sets for libraries needing just one subject or preferring a tangible reference for their shelves or as part of a fully-searchable digital library. The digital product is available to institutions by annual subscription or on perpetual access via www.bloomsburyculturalhistory.com. Individual volumes for academics and researchers interested in specific historical periods are also available in print or digitally via www.bloomsburycollections.com. Robert K.D. Peterson is Professor of Entomology and Department Head of Land Resources and Environmental Sciences at Montana State University, USA. Volume 6 in the Cultural History of Insects set. General Editor: Gene Kritsky is Dean of Behavioral and Natural Sciences at Mount St. Joseph University, USA.
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Chiao, Joan Y. Cultural Neuroscience of Compassion and Empathy. Edited by Emma M. Seppälä, Emiliana Simon-Thomas, Stephanie L. Brown, Monica C. Worline, C. Daryl Cameron, and James R. Doty. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780190464684.013.12.
Abstract:
“Compassion” and “empathy” refer to adaptive emotional responses to suffering in oneself and others that recruit affective and cognitive processes. The human ability to understand the emotional experience of others is fundamental to social cooperation, including altruism. While much of the scientific study of compassion and empathy suggests that genes contribute to empathy and compassion, recent empirical advances suggest gene–environment interactions, as well as cultural differences in development, influence the experience, expression, and regulation of empathy and compassion. The goal of this chapter is to review recent theoretical and empirical advances in the cultural neuroscience of empathy and compassion. Implications of the cultural neuroscientific study of empathy and compassion for public policy and population health disparities will be discussed.
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Westberg, Lars, and Hasse Walum. Oxytocin and Vasopressin Gene Variation and the Neural Basis of Social Behaviors. Edited by Turhan Canli. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199753888.013.011.
Abstract:
Experimental studies in rodents and humans show that the neuropeptides oxytocin and vasopressin are important regulators of behaviors related to social interactions. Evidence for positive effects of oxytocin treatment on symptoms of psychiatric disorders characterized by impaired social functioning has emerged. Numerous studies report associations between various social behaviors, the risk of autism, and polymorphisms inOXTRandAVPR1A. This chapter provides an overview of these genetic association studies. Although many of the published findings are inconclusive and need replication in independent samples, the chapter concludes that variants ofOXTRandAVPR1Aseem to moderate individual variation in different aspects of social behavior. The challenges for future studies include replication of current findings, identification of the functional variants, and characterization of the neural mechanisms mediating the gene-behavior associations, as well as exploration of the pharmacogenetic potential ofOXTRandAVPR1Ain future clinical trials.
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Das-Munshi, Jayati, Tamsin Ford, Matthew Hotopf, Martin Prince, and Robert Stewart, eds. Practical Psychiatric Epidemiology. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198735564.001.0001.
Abstract:
This long-awaited second edition of Practical Psychiatric Epidemiology covers all of the considerable new developments in psychiatric epidemiology that have occurred since the first edition was published in 2003. It includes new content on key topics such as life course epidemiology, gene–environment interactions, bioethics, patient and public involvement in research, mixed methods research, new statistical methods, case registers, policy, and implementation. Looking to the future of this rapidly evolving scientific discipline and how it will respond to the emerging opportunities and challenges posed by ‘big data’, new technologies, open science, and globalization, this new edition will serve as an invaluable reference for clinicians in practice and in training. It will also be of interest to researchers in mental health and people studying or teaching psychiatric epidemiology at undergraduate or postgraduate level.
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Westfall, Nils C., and Charles B. Nemeroff. Child Abuse and Neglect as Risk Factors for Post-Traumatic Stress Disorder. Edited by Charles B. Nemeroff and Charles R. Marmar. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190259440.003.0025.
Abstract:
Child abuse and neglect confer substantially increased risks of developing post-traumatic stress disorder (PTSD) for the victims and possibly even their offspring. Furthermore, they are associated with more severe and treatment-resistant PTSD and common comorbid conditions, such as major depressive disorder. This chapter begins by discussing the epidemiology of child abuse, neglect, and maltreatment-associated PTSD to provide a sense of the nature and scope of these major public health problems, then describes the major ways in which child abuse and neglect may contribute to increased liability to PTSD: maltreatment, victim, and environmental factors; neurobiological changes, including neuroendocrine, neurotransmitter system, structural and functional neuroimaging, inflammatory, and epigenetic changes; interactions with risk gene alleles; and cognitive, psychological, and behavioral changes. A discussion of the implications of this knowledge for future research and the development of new treatments for child maltreatment–associated PTSD follows.
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Appasani, Krishnarao, and Raghu Kiran Appasani, eds. Single-Molecule Science. Cambridge University Press, 2022. http://dx.doi.org/10.1017/9781108525909.
Abstract:
Single Molecule Science (SMS) has emerged from developing, using and combining technologies such as super-resolution microscopy, atomic force microscopy, and optical and magnetic tweezers, alongside sophisticated computational and modelling techniques. This comprehensive, edited volume brings together authoritative overviews of these methods from a biological perspective, and highlights how they can be used to observe and track individual molecules and monitor molecular interactions in living cells. Pioneers in this fast-moving field cover topics such as single molecule optical maps, nanomachines, and protein folding and dynamics. A particular emphasis is also given to mapping DNA molecules for diagnostic purposes, and the study of gene expression. With numerous illustrations, this book reveals how SMS has presented us with a new way of understanding life processes. A must-have for researchers and graduate students, as well as those working in industry, primarily in the areas of biophysics, biological imaging, genomics and structural biology.
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Beaver, Kevin M., Eric J. Connolly, Joseph L. Nedelec, and Joseph A. Schwartz. On the Genetic and Genomic Basis of Aggression, Violence, and Antisocial Behavior. Edited by Rosemary L. Hopcroft. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190299323.013.15.
Abstract:
There is a great deal of interest in examining the genetic and environmental architecture to aggression, violence, and antisocial behaviors. This interest has resulted in hundreds of studies being published that estimate genetic and environmental effects on antisocial phenotypes. The results generated from these studies have been remarkably consistent and have contributed greatly to the knowledge base on the etiology of antisocial behavior. This chapter reviews the research on the genetic basis to antisocial phenotypes by presenting the results related to the heritability of antisocial phenotypes. It also discusses some of the molecular genetic association studies as well as genome-wide association studies that focus on the development of antisocial behaviors. In doing so, it also reviews findings related to gene–environment interactions. The chapter concludes by discussing some of the ways in which these findings could be used for intervention and prevention programs.
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Hellman, Samuel. Academic Medicine. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190650551.003.0003.
Abstract:
The proper education of a doctor must not be restricted to the sciences but rather must include study of the humanities and the social sciences. This is best achieved by having an interactive and physically integrally located medical school. Not only must medicine be based on modern biology, a biology education is also essential for all college undergraduates. One cannot consider genetic engineering if one does not understand what a gene is and how it is controlled. Unique to medical education are the places of medical practice. Besides providing a site of learning, the teaching hospital must provide excellent patient care and be responsive to the surrounding community. The university must embrace these other goals. Society should provide high quality health care for all. This cannot be achieved if only the lowest cost is the goal. While resources are limited, economic efficiency cannot be the only parameter.
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Harris, Brent T., Galam A. Khan, and Saed Sadeghi. Amyotrophic Lateral Sclerosis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0029.
Abstract:
Although the basic gross and microscopic pathological changes in amyotrophic lateral sclerosis (ALS) have been known for more than 100 years, emerging technology and research into the cellular and molecular changes found in this disease are challenging our understanding about the pathogenesis and pathophysiology. All cell types of the CNS/PNS as well as circulating immune cells have been implicated in the pathology of ALS. Numerous genes, their proteins, and environmental factors have also been associated. However, we still do not understand the specific gene-environmental interactions that bring about and drive this devastating disease in most cases. This short chapter does not address the causal factors and molecular pathogeneses that have been hypothesized and actively researched in the pathology of ALS-as these are discussed in other sections of this text. Here, it shows and discusses the basic pathological changes at the tissue and cellular levels that help to establish the pathological diagnosis of ALS at autopsy.
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Schadt, Eric E. Network Methods for Elucidating the Complexity of Common Human Diseases. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0002.
Abstract:
The life sciences are now a significant contributor to the ever expanding digital universe of data, and stand poised to lead in both the generation of big data and the realization of dramatic benefit from it. We can now score variations in DNA across whole genomes; RNA levels and alternative isoforms, metabolite levels, protein levels, and protein state information across the transcriptome, metabolome and proteome; methylation status across the methylome; and construct extensive protein–protein and protein–DNA interaction maps, all in a comprehensive fashion and at the scale of populations of individuals. This chapter describes a number of analytical approaches aimed at inferring causal relationships among variables in very large-scale datasets by leveraging DNA variation as a systematic perturbation source. The causal inference procedures are also demonstrated to enhance the ability to reconstruct truly predictive, probabilistic causal gene networks that reflect the biological processes underlying complex phenotypes like disease.
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Numan, Michael. The Parental Brain. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190848675.001.0001.
Abstract:
The Parental Brain: Mechanisms, Development, and Evolution takes a three-pronged approach to the parental brain. The first part of the book deals with neural mechanisms. Subcortical circuits are crucially involved in parental behavior, and, for most mammals, the physiological events of pregnancy and parturition prime these circuits so that they become responsive to infant stimuli, allowing for the onset of maternal behavior at parturition. However, since paternal behavior and alloparental behavior occur in some mammalian species, alternate mechanisms are shown to exist that regulate the access of infant stimuli to these circuits. In humans, cortical circuits interact with subcortical circuits so that parental feeling states (emotions) and cognitions can be translated into parental behavior. The section on development emphasizes the experiential basis of the intergenerational continuity of normal and abnormal maternal behavior in animals and humans: The way a mother treats her infant affects the development of the infant’s brain and subsequent maternal behavior. Genetic factors, including epigenetic processes and gene by environment (G × E) interactions, are also involved. The chapter on evolution presents evidence that the parental brain most likely provided the foundation or template for other strong prosocial bonds. In particular, cortical and subcortical parental brain circuits have probably been utilized by natural selection to promote the evolution of the hyper-cooperation and hyper-prosociality that exist in human social groups. A unique aspect of this book is its integration of animal and human research to create a complete understanding of the parental brain.
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Kumar, Victor, and Richmond Campbell. A Better Ape. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780197600122.001.0001.
Abstract:
A Better Ape explores the evolution of the moral mind from our ancestors with chimpanzees, through the origins of our genus and our species, to the development of behaviorally modern humans who underwent revolutions in agriculture, urbanization, and industrial technology. The book begins, in Part I, by explaining the biological evolution of sympathy and loyalty in great apes and trust and respect in the earliest humans. These moral emotions are the first element of the moral mind. Part II explains the gene-culture co-evolution of norms, emotions, and reasoning in Homo sapiens. Moral norms of harm, kinship, reciprocity, autonomy, and fairness are the second element of the moral mind. A social capacity for interactive moral reasoning is the third element. Part III of the book explains the cultural co-evolution of social institutions and morality. Family, religious, military, political, and economic institutions expanded small bands into large tribes and created more intense social hierarchies through new moral norms of authority and purity. Finally, Part IV explains the rational and cultural evolution of moral progress and moral regress as human societies experienced gains and losses in inclusivity and equality. Moral progress against racism, homophobia, speciesism, sexism, classism, and global injustice depends on integration of privileged and oppressed people in physical space, social roles, and democratic decision making. The central idea in the book is that all these major evolutionary transitions, from ancestral apes to modern societies, and now human survival of climate change, depend on co-evolution between morality, knowledge, and complex social structure.