Books: 'Gene flow'

1

Poppy, Guy M., and Michael J. Wilkinson, eds. Gene Flow from GM Plants. Oxford, UK: Blackwell Publishing Ltd, 2005. http://dx.doi.org/10.1002/9780470988497.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

M, Poppy Guy, and Wilkinson Michael J, eds. Gene flow from GM plants. Oxford: Blackwell Pub., 2005.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

3

Wei, Wei, and C. Neal Stewart Jr., eds. Gene flow: monitoring, modeling and mitigation. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789247480.0000.

Full text

Abstract:

Abstract Over two decades later, gene flow research as it pertains to genetically engineered crops is still going strong, even in the face of the absence of ecological disasters in the nearly 30 years of widescale biotech crop commercialization. Nonetheless, ecological timeframes are within the study scope of the sort of research performed to date covered in this book. These studies have greatly informed regulations that govern biotech crops. The chapters in this book capture various aspects of scientific disciplines that span from organismal studies, to population and community ecology, to molecular biology.

APA, Harvard, Vancouver, ISO, and other styles

4

Merryanto, Yohanes. Genetic variation and gene flow of hard coral population in Savu Sea Marine National Park, East Nusa Tenggara, Indonesia: Final report international research collaborative and publication (first year). Kupang]: Universitas Kristen Artha Wacana, 2010.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

5

de, Vicente M. Carmen, ed. Gene flow between crops and their wild relatives. Baltimore, Md: Johns Hopkins University Press, 2009.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

6

Miller, Nicholas John. Population structure and gene flow in a host alternating aphid, Pemphigus bursarius. Birmingham: University of Birmingham, 2000.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

7

Blair, Mary Elizabeth. Habitat modification and gene flow in Saimiri oerstedii: Landscape genetics, intraspecific molecular systematics, and conservation. [New York, N.Y.?]: [publisher not identified], 2011.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

8

Nuijten, Edwin. Farmer management of gene flow: The impact of gender and breeding system on genetic diversity and crop improvement in The Gambia. [Wageningen: Wageningen Universiteit], 2005.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

9

Barnes, Jennifer L. Genetic diversity, gene flow and clonal structure of the Salmon River populations of MacFarlane's Four O'Clock Mirabilis Macfarlanei (Nyctaginaceae). Boise, Idaho: Bureau of Land Management, Idaho State Office, 1997.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

10

W, Lutman P. J., and British Crop Protection Council, eds. Gene flow and agriculture: Relevance for transgenic crops : proceedings of a symposium held at the University of Keele, Staffordshire 12-14 April 1999. Farnham: British Crop Protection Council, 1999.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

11

International Union for Conservation of Nature and Natural Resources. Species Survival Commission. Captive Breeding Specialist Group., ed. Subspecies, populations, and gene flow: Possible roles in the conservation management of the Florida Panther : briefing book : working group meeting 30-31 May 1991, National Zoo, Washington D.C.. [S.l.]: [Captive Breeding Specialist Group], 1991.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

12

Eastham, Katie. Genetically modified organisms (GMOs): The significance of gene flow through pollen transfer : a review and interpretation of published literature and recent/current research from the ESF 'Assessing the impact of GM plants' (AIGM) programme for the European Science Foundation and the European Environment Agency. Luxembourg: Official for Official Publications of the European Communities, 2002.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

13

Eastham, Katie. Genetically modified organisms (GMOs): The significance of gene flow through pollen transfer : a review and interpretation of published literature and recent/current research from the ESF 'Assessing the Impact of GM Plants' (ASIGM) programme for the European Science Fountain and the European Environmental Agency / authors, Katie Eastham and Jeremy Sweet. Copenhagen, Denmark: European Environment Agency, 2002.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

14

Jain, Subodh K. Gene Flow in Plants. Chapman & Hall, 1998.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

15

Jain, Subodh K. Gene Flow in Plants. Chapman & Hall, 1998.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

16

Wilkinson, Michael J., and Guy M. Poppy. Gene Flow from GM Plants. Wiley & Sons, Limited, John, 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

17

Wilkinson, Michael J., and Guy M. Poppy. Gene Flow from GM Plants. Wiley & Sons, Incorporated, John, 2008.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

18

Wilkinson, Michael J., and Guy M. Poppy. Gene Flow from GM Plants. Wiley & Sons, Incorporated, John, 2008.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

19

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Genetic rescue by augmenting gene flow. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0006.

Full text

Abstract:

Inbreeding is reduced and genetic diversity enhanced when a small isolated inbred population is crossed to another unrelated population. Crossing can have beneficial or harmful effects on fitness, but beneficial effects predominate, and the risks of harmful ones (outbreeding depression) can be predicted and avoided. For crosses with a low risk of outbreeding depression, there are large and consistent benefits on fitness that persist across generations in outbreeding species. Benefits are greater in species that naturally outbreed than those that inbreed, and increase with the difference in inbreeding coefficient between crossed and inbred populations in mothers and zygotes. However, benefits are similar across invertebrates, vertebrates and plants. There are also important benefits for evolutionary potential of crossing between populations.

APA, Harvard, Vancouver, ISO, and other styles

20

Wei, Wei, and Neal Stewart. Gene Flow: Monitoring, Modelling and Mitigation. CABI, 2021.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

21

Fenster, Charles Barnet. Gene flow and population differentiation in Chamaecrista fasciculata (Leguminosae). 1988.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

22

Sahu, C. K. Gene Flow and Molecular Biology ; Ecological Perspective. A.B.D. Publishers, 2006.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

23

Wilkinson, Michael James. Gene Flow from GM Plants (Biological Sciences Series). Blackwell Publishing Limited, 2005.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

24

Marko, Peter B., and Michael W. Hart, eds. Genetic Analysis of Larval Dispersal, Gene Flow, and Connectivity. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198786962.003.0012.

Full text

Abstract:

Does the dispersal of planktonic larvae promote strong connections between marine populations? Here we describe some of the most commonly used population- and individual-based genetic methods that have enhanced our understanding of larval dispersal and marine connectivity. Both approaches have strengths and weaknesses. Choosing between them depends on whether researchers want to know about average effective rates of connectivity over long timescales (over hundreds to thousands of generations) or recent patterns of connectivity on shorter timescales (one to two generations). The use of both approaches has improved our understanding of larval dispersal distances, the relationship between realized dispersal (from genetics) and dispersal potential (from planktonic larval duration), and the crucial distinction between genetic and demographic connectivity. Although rarely used together, combining population- and individual-based inferences from genetic data will likely further enrich our understanding of the scope and scale of larval dispersal in marine systems.

APA, Harvard, Vancouver, ISO, and other styles

25

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Population fragmentation causes inadequate gene flow and increases extinction risk. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0005.

Full text

Abstract:

Most species now have fragmented distributions, often with adverse genetic consequences. The genetic impacts of population fragmentation depend critically upon gene flow among fragments and their effective sizes. Fragmentation with cessation of gene flow is highly harmful in the long term, leading to greater inbreeding, increased loss of genetic diversity, decreased likelihood of evolutionary adaptation and elevated extinction risk, when compared to a single population of the same total size. The consequences of fragmentation with limited gene flow typically lie between those for a large population with random mating and isolated population fragments with no gene flow.

APA, Harvard, Vancouver, ISO, and other styles

26

Jaquemin-Sablon, Alain. Flow and Image Cytometry ). Springer, 2011.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

27

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Managing gene flow among isolated population fragments. I. Limited information. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0012.

Full text

Abstract:

When the decision is made to augment gene flow into an isolated population, managers must decide how to augment gene flow, when to start, from where to take the individuals or gametes to be added, how many, which individuals, how often and when to cease. Even without detailed genetic data, sound genetic management strategies for augmenting gene flow can be instituted by considering population genetics theory, and/or computer simulations. When detailed data are lacking, moving (translocating) some individuals into isolated inbred population fragments is better than moving none, as long as the risk of outbreeding depression is low.

APA, Harvard, Vancouver, ISO, and other styles

28

Gene Flow and Agriculture: Relevance and Transgenic Crops (Symposium Proceedings). BCPC Publications, 2000.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

29

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Managing gene flow among isolated population fragments. II. Management based on kinship. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0013.

Full text

Abstract:

With more detailed genetic information, more precise genetic management of fragmented populations can be achieved, leading to improved retention of genetic diversity and lower inbreeding. Using mean kinship within and between populations (estimated from modeling, pedigrees, genetic markers or genomes), and moving individuals among fragments with the lowest between fragment mean kinships provides the best approach to gene flow management. Populations should then be monitored to confirm that movement of individuals has resulted in the desired levels of gene flow, and that genetic diversity has been enhanced.

APA, Harvard, Vancouver, ISO, and other styles

30

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Are there populations suffering genetic erosion that would benefit from augmented gene flow? Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0011.

Full text

Abstract:

Having identified small geographically and genetically isolated populations, we need to determine whether they are suffering genetic erosion, and if so, whether there are any other populations to which they could be crossed. We should next ask whether crossing is expected to be harmful or beneficial, and if beneficial, whether the benefits would be large enough to justify a genetic rescue attempt. Here, we address these questions based on the principles established in the preceding chapters.

APA, Harvard, Vancouver, ISO, and other styles

31

Wehling, Wayne Franklin. Geography of host use, oviposition preference, and gene flow in the anise swallowtail butterfly (Papilio zelicaon). 1994.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

32

Schlueter, Mark A. Population genetic structure and gene flow within three coral reef fish species in the Florida Keys. 1997.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

33

Rouleau, Jessica Leigh. Partial least squares modeling of keratinocyte differentiation through the integration of gene expression profiles and flow cytometry analysis. 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

34

Hickerson, Michael J. Gene flow and phylogeography of the northern clingfish (Gobbiesox maeandricus) as inferred from mitochondrial DNA control region sequence analysis. 1997.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

35

Erickson, Vicky J. The influence of distance and floral phenology on pollen gene flow and mating system patterns in a coastal Douglas-fir seed orchard. 1987.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

36

Dunley, John E. Genetics and gene flow of organophosphate resistance in three predatory mites, Amblyseius andersoni Chant, Typhlodromus pyri Scheuten and Metaseiulus occidentalis Nesbitt (Acarina: Phytoseiidae), in Oregon. 1993.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

37

Dyer, Paul S., Carol A. Munro, and Rosie E. Bradshaw. Fungal genetics. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0005.

Full text

Abstract:

Fungi have been long used as model organisms to investigate genetic and cellular processes. An overview is provided of how fungi function at a genetic level, including ploidy, gene structure, and gene flow by sexual and asexual processes. The tools used to study fungal genetics are then described, such techniques having widespread applications in medical mycology research. Classical genetic analysis includes the use of gene mapping by sexual crossing and tetrad analysis, and forward genetic experimentation based on mutagenesis, for which various mutant screening approaches are described. Molecular genetic analysis includes gene manipulation by transformation; different methods for gene knockout and targeting, and their application for forward and reverse genetic approaches, are outlined. Finally, molecular genetic methods used to study gene expression and function are reviewed, including use of inducible or constitutive overexpression, real-time PCR, cellular localization of gene products by fluorescent tagging, and detection of protein–protein interactions.

APA, Harvard, Vancouver, ISO, and other styles

38

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Take home messages. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0015.

Full text

Abstract:

We recommend augmentation of gene flow for isolated population fragments that are suffering inbreeding and low genetic diversity, provided that proposed population crosses have low risks of outbreeding depression, and the predicted benefits justify the financial costs.

APA, Harvard, Vancouver, ISO, and other styles

39

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Introduction. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0001.

Full text

Abstract:

Genetic management of fragmented populations is one of the major, largely unaddressed issues in biodiversity conservation. Many species across the planet have fragmented distributions with small isolated populations that are potentially suffering from inbreeding and loss of genetic diversity (genetic erosion), leading to elevated extinction risk. Fortunately, genetic deterioration can usually be remedied by augmenting gene flow (crossing between populations within species), yet this is rarely done, in part because of fears that crossing may be harmful (but it is possible to predict when this will occur). Benefits and risks of genetic problems are sometimes altered in species with diverse mating systems and modes of inheritance. Adequate genetic management depends on appropriate delineation of species. We address management of gene flow between previously isolated populations and genetic management under global climate change.

APA, Harvard, Vancouver, ISO, and other styles

40

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Genetic Management of Fragmented Animal and Plant Populations. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.001.0001.

Full text

Abstract:

The biological diversity of the planet is being rapidly depleted due to the direct and indirect consequences of human activity. As the size of animal and plant populations decrease and fragmentation increases, loss of genetic diversity reduces their ability to adapt to changes in the environment, with inbreeding and reduced fitness inevitable consequences for many species. Many small isolated populations are going extinct unnecessarily. In many cases, such populations can be genetically rescued by gene flow into them from another population within the species, but this is very rarely done. This novel and authoritative book addresses the issues involved in genetic management of fragmented animal and plant populations, including inbreeding depression, loss of genetic diversity and elevated extinction risk in small isolated populations, augmentation of gene flow, genetic rescue, causes of outbreeding depression and predicting its occurrence, desirability and implementation of genetic translocations to cope with climate change, and defining and diagnosing species for conservation purposes.

APA, Harvard, Vancouver, ISO, and other styles

41

Kirchman, David L. Genomes and meta-omics for microbes. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789406.003.0005.

Full text

Abstract:

The sequencing of entire genomes of microbes grown in pure cultures is now routine. The sequence data from cultivated microbes have provided insights into these microbes and their uncultivated relatives. Sequencing studies have found that bacterial genomes range from 0.18 Mb (intracellular symbiont) to 13 Mb (a soil bacterium), whereas genomes of eukaryotes are much bigger. Genomes from eukaryotes and prokaryotes are organized quite differently. While bacteria and their small genomes often grow faster than eukaryotes, there is no correlation between genome size and growth rates among the bacteria examined so far. Genomic studies have also highlighted the importance of genes exchanged (“horizontal gene transfer”) between organisms, seemingly unrelated, as defined by rRNA gene sequences. Microbial ecologists use metagenomics to sequence all microbes in a community. This approach has revealed unsuspected physiological processes in microbes, such as the occurrence of a light-driven proton pump, rhodopsin, in bacteria (dubbed proteorhodopsin). Genomes from single cells isolated by flow cytometry have also provided insights about the ecophysiology of both bacteria and protists. Oligotrophic bacteria have streamlined genomes, which are usually small but with a high fraction of genomic material devoted to protein-encoding genes, and few transcriptional control mechanisms. The study of all transcripts from a natural community, metatranscriptomics, has been informative about the response of eukaryotes as well as bacteria to changing environmental conditions.

APA, Harvard, Vancouver, ISO, and other styles

42

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark D. B. Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. Evolutionary genetics of small populations. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198783398.003.0002.

Full text

Abstract:

Genetic management of fragmented populations involves the application of evolutionary genetic theory and knowledge to alleviate problems due to inbreeding and loss of genetic diversity in small population fragments. Populations evolve through the effects of mutation, natural selection, chance (genetic drift) and gene flow (migration). Large outbreeding, sexually reproducing populations typically contain substantial genetic diversity, while small populations typically contain reduced levels. Genetic impacts of small population size on inbreeding, loss of genetic diversity and population differentiation are determined by the genetically effective population size, which is usually much smaller than the number of individuals.

APA, Harvard, Vancouver, ISO, and other styles

43

Frankham, Richard, Jonathan D. Ballou, Katherine Ralls, Mark Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, and Paul Sunnucks. A Practical Guide for Genetic Management of Fragmented Animal and Plant Populations. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198783411.001.0001.

Full text

Abstract:

The biological diversity of the planet is being rapidly depleted due to the direct and indirect consequences of human activity. As the size of wild animal and plant populations decreases and fragmentation increases, inbreeding reduces fitness and loss of genetic diversity reduces their ability to adapt to changes in the environment. Many small isolated populations are going extinct unnecessarily. In many cases, such populations can be genetically rescued by gene flow from another population within the species, but this is very rarely done. This book provides a practical guide to the genetic management of fragmented animal and plant populations.

APA, Harvard, Vancouver, ISO, and other styles

44

Greilhuber, Johann, Jaroslav Dolezel, and Jan Suda. Flow Cytometry with Plant Cells: Analysis of Genes, Chromosomes and Genomes. Wiley & Sons, Limited, John, 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

45

Flow cytometry with plant cells: Analysis of genes, chromosomes and genomes. Weinheim: Wiley-VCH, 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

46

Greilhuber, Johann, Jaroslav Dolezel, and Jan Suda. Flow Cytometry with Plant Cells: Analysis of Genes, Chromosomes and Genomes. Wiley & Sons, Incorporated, John, 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

47

(Editor), Jaroslav Dolezel, Johann Greilhuber (Editor), and Jan Suda (Editor), eds. Flow Cytometry with Plant Cells: Analysis of Genes, Chromosomes and Genomes. Wiley-VCH, 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

48

Jobson, Richard W., Paulo C. Baleeiro, and Cástor Guisande. Systematics and evolution of Lentibulariaceae: III. Utricularia. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198779841.003.0008.

Full text

Abstract:

Utricularia is a morphologically and ecologically diverse genus currently comprising more than 230 species divided into three subgenera—Polypompholyx, Utricularia, and Bivalvaria—and 35 sections. The genus is distributed worldwide except on the poles and most oceanic islands. The Neotropics has the highest species diversity, followed by Australia. Compared to its sister genera, Utricularia has undergone greater rates of speciation, which are linked to its extreme morphological flexibility that has resulted in the evolution of habitat-specific forms: terrestrial, rheophytic, aquatic, lithophytic, and epiphytic. Molecular phylogenetic studies have resolved relationships for 44% of the species across 80% of the sections. Scant data are available for phylogeography or population-level processes such as gene flow, hybridization, or pollination. Because nearly 90% of the species are endemics, data are urgently needed to determine how to protect vulnerable species and their habitats.

APA, Harvard, Vancouver, ISO, and other styles

49

Douglas, Kenneth. Bioprinting. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190943547.001.0001.

Full text

Abstract:

Abstract: This book describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the bioprinting field and clarifies their meaning using plain language. Readers will learn about bioink—a bioprinting material containing living cells and supportive biomaterials. In addition, readers will become at ease with concepts such as fugitive inks (sacrificial inks used to make channels for blood flow), extracellular matrices (the biological environment surrounding cells), decellularization (the process of isolating cells from their native environment), hydrogels (water-based substances that can substitute for the extracellular matrix), rheology (the flow properties of a bioink), and bioreactors (containers to provide the environment cells need to thrive and multiply). Further vocabulary that will become familiar includes diffusion (passive movement of oxygen and nutrients from regions of high concentration to regions of low concentration), stem cells (cells with the potential to develop into different bodily cell types), progenitor cells (early descendants of stem cells), gene expression (the process by which proteins develop from instructions in our DNA), and growth factors (substances—often proteins—that stimulate cell growth, proliferation, and differentiation). The book contains an extensive glossary for quick reference.

APA, Harvard, Vancouver, ISO, and other styles

50

Thomas, Ranjeny, and Andrew P. Cope. Pathogenesis of rheumatoid arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0109.

Full text

Abstract:

In depth molecular and cellular analysis of synovial tissue and fluid from patients with rheumatoid arthritis has provided important insights into understanding disease pathogenesis. Advances in the 1980s and 1990s included modern cloning strategies, sensitive and specific assays for inflammatory mediators, production of high-affinity neutralizing monoclonal antibodies, advances in flow cytometry, and gene targeting and transgenic strategies in rodents. In the 21st century, technological platforms offer unparalleled opportunities for systematic and unbiased interrogation of the disease process at a whole-genome level. Here we describe the key molecular and cellular characteristics of the inflamed synovium and how infiltrating cells get there. With this background, we outline current concepts of the different phases of disease, how the first phase of genetic susceptibility evolves into autoimmunity, triggered by the exposome, prior to the onset of clinically apparent inflammatory disease. We then describe the pathways that actively contribute to this early inflammatory phase and document the key effector cells and molecules of the innate and adaptive immune systems that orchestrate and maintain chronic synovial inflammatory responses. We summarize how this inflammatory milieu translates to cartilage destruction and bone resorption in synovial joints, and conclude by reviewing those factors in inflamed synovium that promote immune homeostasis.

APA, Harvard, Vancouver, ISO, and other styles

Books on the topic 'Gene flow'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles