Dissertations / Theses on the topic 'Gene family'
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Newton, Craig Hunter. "A Drosophila tRNA gene family." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29252.
Full textMedicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate
Cadieux, Benoît. "The zebrafish progranulin gene family /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84486.
Full textJanousek, Vaclav, Robert Karn, and Christina Laukaitis. "The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family." BioMed Central, 2013. http://hdl.handle.net/10150/610385.
Full textThangavelu, Madan. "The actin gene family of tobacco." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335212.
Full textCotton, James A. "Vertebrate phylogenomics and gene family evolution." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274764.
Full textChattaway, John Antony. "Characterising the polymorphic BG gene family." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707953.
Full textDubb, Lindsey. "A likelihood model of gene family evolution /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/10264.
Full textDörr, Daniel [Verfasser]. "Gene family-free genome comparison / Daniel Dörr." Bielefeld : Universitätsbibliothek Bielefeld, 2016. http://d-nb.info/1096457229/34.
Full textRawson, Stephen J. "The Chinese hamster phosphoglycerate kinase gene family." Thesis, University of Leicester, 1986. http://hdl.handle.net/2381/35136.
Full textDrummond, Revel Scott MacGregor. "The AtMRS2 gene family from Arabidopsis thaliana." Thesis, University of Auckland, 2004. http://hdl.handle.net/2292/15.
Full textSjöstrand, Joel. "Reconciling gene family evolution and species evolution." Doctoral thesis, Stockholms universitet, Numerisk analys och datalogi (NADA), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-93346.
Full textArters evolution kan i många fall beskrivas med ett träd, vilket redan Darwins anteckningsböcker från HMS Beagle vittnar om. Detta gäller också homologa gener; en gen i en ancestral art kan – genom genduplikationer, genförluster, lateral gentransfer (LGT) och artbildningar – ge upphov till en genfamilj spridd över samtida arter. Att från sekvenser från nu levande arter rekonstruera genfamiljens framväxt – genträdet – är icke-trivialt på grund av genetisk rekombination och sekvensevolution. Genträdet är emellertid av biologiskt intresse, i synnerhet för att det möjliggör antaganden om funktionellt släktskap mellan nutida genpar. Denna avhandling behandlar biologiskt välgrundade sannolikhetsmodeller för genfamiljsevolution. Dessa modeller tar hjälp av artevolutionens starka inverkan på genfamiljens historia, och ger väsentligen upphov till en förlikning av genträd och artträd. Genom Bayesiansk inferens baserad på Markov-chain Monte Carlo (MCMC) visar vi att våra metoder presterar bättre genträdsskattningar än traditionella ansatser som inte tar artträdet i beaktning. Mer specifikt beskriver vi en modell som omfattar genduplikationer, genförluster, en relaxerad molekylär klocka, samt sekvensevolution, och visar att metoden ger högkvalitativa skattningar på både syntetiska och biologiska data. Vidare presenterar vi två utvidgningar av detta ramverk som möjliggör (i) genträdsskattningar med tidpunkter för duplikationer, samt (ii) probabilistiska ortologiskattningar – d.v.s. att två nutida gener härstammar från en artbildning. Slutligen presenterar vi en modell som inkluderar LGT utöver ovan nämnda mekanismer. De beräkningsmässiga svårigheter som LGT ger upphov till löses med ett intrikat ramverk av dynamisk programmering och numeriska metoder för differentialekvationer. Vi tillämpar metoden för att skatta LGT- och duplikationsraten hos två bakteriella dataset där LGT förmodas ha spelat en central roll. Vi visar också att traditionella metoder – där genträd skattas och förlikas med artträdet i separata steg – tenderar att ge sämre genträdsskattningar, och därmed överskatta antalet LGT-händelser.
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Manuscript. Paper 5: Manuscript.
Buerger, Katrin. "Functional analysis of the Mospd gene family." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4435.
Full textTregear, James W. "The lectin gene family of Ricinus communis." Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/101217/.
Full textTunnacliffe, Edward Alan John. "Gene expression dynamics underlying diversification and expansion of an actin gene family." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041510/.
Full textJopling, Catherine L. "Internal ribosome entry in the myc gene family." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29662.
Full textDavid, Jocelyn. "Characterization of the nlp gene family of Enterobacteriaceae." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68166.
Full textRecently, a new gene, called nlp (for Ner-like-protein), was discovered in E. coli and was shown to also be present in several other Enterobacteriaceae. The Nlp protein is highly homologous to the Ner repressors of transposable bacteriophages Mu and D108.
In order to determine if the nucleotide sequence of the nlp gene was conserved in enteric bacteria, and also for studying the potential evolutionary relationship between bacteria and bacteriophages, the E. coli C nlp gene was cloned and sequenced. The resulting nucleotide sequence was compared to the nlp genes of E. coli W3110 and Shigella sonneii.
Results showed that the coding region of the E. coli C nlp gene is identical to its E. coli W3110 counterpart. In S. sonneii, the nlp gene sequence revealed three nucleotide substitutions when compared to the two E. coli nlp sequences. Nevertheless, these variations were located in the third position of codons and had no effect on the primary structure of the Nlp protein.
Durcan, Peter Joseph. "Examination of the Kirrel gene family during myogenesis." Thesis, Manchester Metropolitan University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556700.
Full textKuo, Chien-Wen Sharon. "The genomic structure of the CYP4 gene family." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310930.
Full textGay, Robert Daniel. "Neuronal gene regulation by POU family transcription factors." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267026.
Full textSingh, Prashant. "Molecular analysis of the Arabidopsis CP12 gene family." Thesis, University of Essex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437812.
Full textBilsland, Caroline A. G. "Expression of the human leucocyte CD1 gene family." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334101.
Full textNichols, Hester. "An analysis of human cytomegalovirus gene family function." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/115570/.
Full textWise, Dawnne O'neal. "The (gamma)-tubulin gene family in Homo sapiens /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488193272069132.
Full textTilley, Michael R. "Inheritance and gene regulation in a ribosomal protein gene family of arabidopsis thaliana." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1071849759.
Full textCarneiro, Newton Portilho 1963. "Patterns of gene expression in maize endosperm: Characterization of the eEF1A gene family." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282611.
Full textLloyd, Sarah Elisabeth. "Analysis of ZNF6 : a human zinc finger gene related to the ZFY gene family." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320126.
Full textCollignon, Jerome Vincent. "Study of a new family of genes relating to the mammalian testis determining gene." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316658.
Full textO'Leary, Christine Marie. "Expression of the Ets family in the lens." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 2.78 Mb., 100 p, 2005. http://wwwlib.umi.com/dissertations/fullcit/1428194.
Full textAdra, Chaker Nadim. "X chromosome inactivation and the phosphoglycerate kinase gene family." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5308.
Full textDyall, Sabrina Devi. "Characterisation of the LmcDNA2 gene family of Leishmania major." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243853.
Full textGreen, Jasper B. "The stomatin family and its gene neighbours throughout prokaryotes." Thesis, University of York, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519845.
Full textTomkins, Janine. "Molecular and evolutionary investigation of the phosphoglucomutase gene family." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362936.
Full textAbuzaid, Amani Omar S. "Functional analysis of the CP12 gene family in Arabidopsis." Thesis, University of Essex, 2017. http://repository.essex.ac.uk/20292/.
Full textLipinski, Marta M. (Marta Monika) 1971. "The retinoblastoma gene family in tumor suppression and development." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8317.
Full textIncludes bibliographical references.
The retinoblastoma tumor suppressor and the closely related p107 and p130 proteins play important roles in the regulation of both tumorigenesis and tissue-specific differentiation. To determine the role of Rb in development more precisely, we analyzed chimeric embryos and adults made with marked Rb-/- cells. We demonstrated that although brains of chimeric embryos exhibited extensive ectopic S-phase entry, unlike in germline Rb-/- littermates, in these chimeras the majority of Rb-deficient cells survived and differentiated into neuronal fates. Therefore, the role of Rb during development can be divided into a cell-autonomous function in exit from the cell cycle and a non-cell autonomous role in the suppression of apoptosis and induction of differentiation. Rb-/- ES cells were also able to efficiently differentiate into neurons in vitro. However, similarly to the situation observed in the chimeric embryos, Rb-/- neuronal cells failed to properly exit the cell cycle and continued to progress through the S-phase, while displaying fully differentiated neuronal morphology and expressing mature neuronal markers. Therefore, Rb function is not required for the commitment to the neuronal lineage or progression of neuronal differentiation but necessary for the cell cycle exit of differentiating neurons. In agreement, in wild-type differentiating ES cells, activity of the retinoblastoma protein (pRB) was increased specifically at the time of neuronal precursor cell cycle exit.
(cont.) In differentiating Rb-/- ES cells, levels of the pRB-related p107 protein were specifically elevated, suggesting that it might be substituting for pRB to allow efficient neuronal differentiation. In order to determine if p107 and p130 proteins might play a role in tissue-specificity of tumorigenesis upon loss of Rb, we investigated the function of these proteins in the mouse pituitary tumors. Both p107 and p130 were present and active in primary pituitary tumors but levels of p107 were very low while protein levels if pocket-family targets, E2F 1 and E2F 4 were elevated. Although normally bound exclusively to E2F 4, in pituitary tumors p107 and p130 were able to form complexes also with E2F 1. Therefore, in the absence of pRB, p107 and p130 are able to bind and may regulate the function of the activating E2F species. Despite this partial substitution, p107 and p130 are unable to prevent pituitary tumorigenesis in Rb+'- mice, likely due to the elevated E2F expression. The levels of expression of the pRB- versus the E2F-family proteins in different tissues might be contributing to the sensitivity of these tissues to tumor development upon loss of Rb.
Marta M. Lipinski.
Ph.D.
Aguileta, Estrada Elizabeth Gabriela. "The evolution of the vertebrate beta globin gene family." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446501/.
Full textWyatt, Niki Danielle. "Role of the STRA6 gene family in vertebrate development." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11715.
Full textInada, Akari. "The regulation of insulin gene transcription by CREM family." Kyoto University, 2001. http://hdl.handle.net/2433/150503.
Full textElferink, Lisa Anne. "Characterization of the chicken phenobarbital inducible P450 gene family /." Title page, contents and introduction only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phe39.pdf.
Full textKingo, Külli. "The interleuken-10 family cytokines gene polymorphisms in plaque psoriasis /." Online version, 2005. http://dspace.utlib.ee/dspace/bitstream/10062/1281/5/kingo.pdf.
Full textEades, Caleb Joshua. "Characterization of the alpha-mannosidase gene family in filamentous fungi." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58565.pdf.
Full textCochrane, Fiona Gutiez. "Characterisation of the SIRP gene family and CD47 viral homologues." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419242.
Full textKim, Jeehee. "Biological role and genetic redundancy within the ebf gene family." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-182813.
Full textEdwards, Eira Wyn. "Molecular biology of the oleosin gene family of Brassica napus." Thesis, Durham University, 1991. http://etheses.dur.ac.uk/6160/.
Full textLucas, Carolina Escobar. "Regulation of the ascorbate peroxidase gene family in Arabidopsis thaliana." Thesis, University of East Anglia, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267771.
Full textVirk, Guneet Kaur. "Characterization of the CPI-17 Gene Family in Danio rerio." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/3141.
Full textStock, C. J. W. "The interleukin 1 gene family in systemic juvenile idiopathic arthritis." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1331908/.
Full textLawton, J. C. "Investigation of the cir multi-gene family of Plasmodium chabaudi." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1338585/.
Full textLynch, Catherine. "The calcitonin gene peptide family in health and malignant disease." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47162.
Full textJawdekar, Gauri W. "Transcriptional regulation of the human small nuclear RNA gene family." Diss., Connect to online resource - MSU authorized users, 2006.
Find full textTitle from PDF t.p. (viewed on June 19, 2009) Includes bibliographical references. Also issued in print.
Huang, Li-Fen. "Molecular analysis of an acid invertase gene family in Arabidopsis." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013827.
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