Academic literature on the topic 'Gene Editing (CRISPR/Cas9)'
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Journal articles on the topic "Gene Editing (CRISPR/Cas9)":
Paul Strickland, Skylar. "CRISPR-Cas9: Gene Editing." International Journal of Science and Research (IJSR) 12, no. 6 (June 5, 2023): 2439–42. http://dx.doi.org/10.21275/sr23624231215.
Yang, Jiayi. "Applications of the CRISPR-Cas9 system in cancer models." Theoretical and Natural Science 21, no. 1 (December 20, 2023): 28–33. http://dx.doi.org/10.54254/2753-8818/21/20230804.
Isachenko, Nadya, Gayane Aleksanyan, Paul Diehl, and Donato Tedesco. "Abstract 2950: CRISPR/saCas9 and CRISPR/spCas9 systems for combinatorial genetic screens (CRISPR-KO, CRISPRa, CRISPRi)." Cancer Research 84, no. 6_Supplement (March 22, 2024): 2950. http://dx.doi.org/10.1158/1538-7445.am2024-2950.
Gong, Chongzhi, Shengchan Huang, Rentao Song, and Weiwei Qi. "Comparative Study between the CRISPR/Cpf1 (Cas12a) and CRISPR/Cas9 Systems for Multiplex Gene Editing in Maize." Agriculture 11, no. 5 (May 10, 2021): 429. http://dx.doi.org/10.3390/agriculture11050429.
Dowdy, Steven F. "Controlling CRISPR-Cas9 Gene Editing." New England Journal of Medicine 381, no. 3 (July 18, 2019): 289–90. http://dx.doi.org/10.1056/nejmcibr1906886.
Wu, Yirui. "The Development of Gene Editing Technology and Controversial Issues: A Discussion." Highlights in Science, Engineering and Technology 91 (April 15, 2024): 123–30. http://dx.doi.org/10.54097/6gj0tk11.
Yang, Lan, Hao Li, Yao Han, Yingjie Song, Mingchen Wei, Mengya Fang, and Yansong Sun. "CRISPR/Cas9 Gene Editing System Can Alter Gene Expression and Induce DNA Damage Accumulation." Genes 14, no. 4 (March 27, 2023): 806. http://dx.doi.org/10.3390/genes14040806.
Zhou, Junming, Xinchao Luan, Yixuan Liu, Lixue Wang, Jiaxin Wang, Songnan Yang, Shuying Liu, Jun Zhang, Huijing Liu, and Dan Yao. "Strategies and Methods for Improving the Efficiency of CRISPR/Cas9 Gene Editing in Plant Molecular Breeding." Plants 12, no. 7 (March 28, 2023): 1478. http://dx.doi.org/10.3390/plants12071478.
Desai, Devam, Hiral Panchal, Shivani Patel, and Ketul Nayak. "CRISPR - CAS9 GENE EDITING: A REVIEW." International Journal of Advanced Research 8, no. 10 (October 31, 2020): 1127–32. http://dx.doi.org/10.21474/ijar01/11943.
Preece, Roland, and Christos Georgiadis. "Emerging CRISPR/Cas9 applications for T-cell gene editing." Emerging Topics in Life Sciences 3, no. 3 (April 2, 2019): 261–75. http://dx.doi.org/10.1042/etls20180144.
Dissertations / Theses on the topic "Gene Editing (CRISPR/Cas9)":
Roidos, Paris. "Genome editing with the CRISPR Cas9 system." Thesis, KTH, Skolan för bioteknologi (BIO), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-163694.
Sousa, Maria Cristina Ferreira de. "Targeted gene editing in Neospora caninum using CRISPR/Cas9." Master's thesis, Universidade de Évora, 2021. http://hdl.handle.net/10174/29205.
Cui, Xiucheng. "Targeted Gene Editing Using CRISPR/Cas9 in a Wheat Protoplast System." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36543.
Croci, Susanna. "CRISPR-Cas9 gene editing: a new promising treatment for Rett syndrome." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1120546.
Cullot, Grégoire. "Génotoxicité des systèmes CRISPR-Cas9." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0344.
Gene therapy is a promising therapeutic strategy for the monogenic diseases treatment. If the first approaches, called additive, have relied on the use of viral vectors, a growing share is now turning to gene editing. Less than a decade after its characterization, the CRISPR-Cas9 system has moved gene editing to a clinical stage. However, in the same period of time, several questions have been raised regarding the genotoxicity that can be induced by Cas9. An emerging literature points to the risk of genotoxicity at the targeted site. The thesis work presented here is part of this theme. The first part of the study aimed to describe the genotoxicity induced by a single double-stranded break made by Cas9. Characterization of the effects was done both at the nucleotide level, by monitoring the HDR / InDels balance, but also at the chromosome scale. The monitoring of chromosomal integrity has brought to light a new risk of genotoxicity that was not characterized. A sensitive and specific detection system for this risk has been developed to further characterize it. The second objective was to address the limitations of unwanted genotoxicity by developing a safer and more efficient gene editing method through the use of a single single-stranded breakage by Cas9D10A-nickase
Giada, Beligni. "Application of the CRISPR-Cas9 genome editing approach for the correction of the p.Gly2019Ser (c.6055G>A) LRRK2 variant in Parkinson Disease." Doctoral thesis, Università di Siena, 2022. https://hdl.handle.net/11365/1220257.
Poggi, Lucie. "Gene editing approaches of microsatellite disorders : shortening expanded repeats." Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS412.
Microsatellite disorders are a specific class of human diseases that are due to the expansion of repeated sequences above pathological thresholds. These disorders have varying symptoms and pathogenic mechanisms, caused by the expanded repeat. No cure exists for any of these dramatic conditions. This thesis is investigating new gene editing approaches to remove pathological expansions in the human genome. In a first part, a yeast-based screen was constructed to identify potent CRISPR-associated nucleases that can cut these microsatellites. The second part focuses on myotonic dystrophy type 1 (DM1), which is due to and expanded CTG repeat tract located at the 3’UTR of the DMKP gene. A nuclease, TALENCTG was designed to induce a double strand break into the CTG repeats. It was previously shown to be active in yeast cells, inducing contractions of CTG repeats from a DM1 patient integrated into the yeast genome. The TALEN was tested in DM1 patient cells. The nuclease was found to trigger some contraction events in patient cells. In vivo experiments were carried out in a mouse model of myotonic dystrophy type 1 containing a human genomic fragment from a patient and 1000 CTG. Intramuscular injections of recombinant AAV encoding the TALENCTG revealed that the nuclease is toxic and/or immunogenic in muscle cells in the tested experimental conditions. Finally, the reporter assay integrated in yeast to screen nucleases was transposed in HEK293FS cell line. The integrated cassette contains a CTG expansion from a myotonic dystrophy type 1 patient flanked by two halves of GFP genes. This system would enable to find nucleases active in human cells
Waghulde, Harshal B. "Mapping and CRISPR/Cas9 Gene Editing for Identifying Novel Genomic Factors Influencing Blood Pressure." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1470402637.
Jayavaradhan, Rajeswari. "Optimization of Gene Editing Approaches for Human Hematopoietic Stem Cells." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543919940219677.
Ryu, Junghyun. "The direct injection of CRISPR/Cas9 system into porcine zygotes for genetically modified pig production." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/101763.
Doctor of Philosophy
Books on the topic "Gene Editing (CRISPR/Cas9)":
Little, Jamie. Using Genomic Transgenes and the CRISPR/Cas9 Gene Editing System to Understand How Hedgehog Signaling Regulates Costal2 and Cubitus Interruptus in Drosophila melanogaster. [New York, N.Y.?]: [publisher not identified], 2017.
Luo, Yonglun, ed. CRISPR Gene Editing. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9170-9.
María Vaschetto, Luis. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases. New York: CRC Press, 2021. http://dx.doi.org/10.1201/9781003088516.
Isaacson, Walter. Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. New York, USA: Simon & Schuster, 2021.
Service, Congressional. Advanced Gene Editing: CRISPR-Cas9. Independently Published, 2019.
Kozubek, Jim. Modern Prometheus: Editing the Human Genome with Crispr-Cas9. Cambridge University Press, 2018.
CRISPR/Cas9: Einschneidende Revolution in der Gentechnik. Berlin, Germany: Springer, 2018.
CRISPR/Cas9: Einschneidende Revolution in der Gentechnik. Springer Verlag, 2018.
Yamamoto, Takashi. Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System. Springer, 2016.
Yamamoto, Takashi. Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System. Springer, 2015.
Book chapters on the topic "Gene Editing (CRISPR/Cas9)":
Gopika, Boro Arthi, Arumugam Vijaya Anand, Natchiappan Senthilkumar, Senthil Kalaiselvi, and Santhanu Krishnapriya. "Gene Editing Using CRISPR/Cas9 System." In CRISPR and Plant Functional Genomics, 258–70. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003387060-15.
Bao, Aili, Lam-Son Phan Tran, and Dong Cao. "CRISPR/Cas9-Based Gene Editing in Soybean." In Legume Genomics, 349–64. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0235-5_19.
García-Caparrós, Pedro. "Breeding for Yield Quality Parameters and Abiotic Stress in Tomato Using Genome Editing." In A Roadmap for Plant Genome Editing, 395–409. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-46150-7_23.
Ito, Takeshi, Hiroshi Yamatani, Takashi Nobusawa, and Makoto Kusaba. "Development of a CRISPR-Cas9-Based Multiplex Genome-Editing Vector and Stay-Green Lettuce." In Gene Editing in Plants, 405–14. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-8529-6_15.
Erol, Nihal Öztolan. "Soybean Improvement and the Role of Gene Editing." In A Roadmap for Plant Genome Editing, 271–89. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-46150-7_17.
Reem, Nathan T., and Joyce Van Eck. "Application of CRISPR/Cas9-Mediated Gene Editing in Tomato." In Methods in Molecular Biology, 171–82. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-8991-1_13.
Everman, Jamie L., Cydney Rios, and Max A. Seibold. "Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9." In Methods in Molecular Biology, 267–92. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7471-9_15.
Liao, Xiaofeng, and Liwu Li. "CRISPR-Cas9-Induced Gene Editing in Primary Human Monocytes." In Methods in Molecular Biology, 189–93. New York, NY: Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3754-8_15.
Singh, Surender, Roni Chaudhary, Siddhant Chaturvedi, and Siddharth Tiwari. "Deciphering the Role of CRISPR/Cas9 in the Amelioration of Abiotic and Biotic Stress Conditions." In Gene Editing in Plants, 193–226. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-8529-6_8.
Razzaq, Ali, Ghulam Mustafa, Muhammad Amjad Ali, Muhammad Sarwar Khan, and Faiz Ahmad Joyia. "CRISPR-mediated genome editing in maize for improved abiotic stress tolerance." In Molecular breeding in wheat, maize and sorghum: strategies for improving abiotic stress tolerance and yield, 405–20. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789245431.0023.
Conference papers on the topic "Gene Editing (CRISPR/Cas9)":
Stacey, Minviluz. "Utility of CRISPR/Cas in accelerating gene discovery in soybean." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/rzne1660.
Wang, Chihan. "Applications of CRISPR/Cas9 gene-editing technology in cancer." In Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), edited by Alan Wang. SPIE, 2024. http://dx.doi.org/10.1117/12.3013218.
Zhiyang, Gan. "Applications and challenges for CRISPR/Cas9-mediated gene editing." In 7TH INTERNATIONAL CONFERENCE ON MATHEMATICS: PURE, APPLIED AND COMPUTATION: Mathematics of Quantum Computing. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0115407.
Li, Ling. "CRISPR/Cas9-based editing of OsNF-YC4/GmNF-YC4 promoter yields high-protein crops." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/qsgt8379.
Cheng, Qiming. "The application of CRISPR/Cas9 technology in plant gene editing." In Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), edited by Alan Wang. SPIE, 2024. http://dx.doi.org/10.1117/12.3012857.
Kershanskaya, O. I., Zh Kuli, A. Maulenbay, D. Nelidova, S. N. Nelidov, and J. Stephens. "NEW CRISPR/CAS9 GENE EDITING TECHNOLOGY FOR DEVELOPMENT OF AGRICULTURAL BIOTECHNOLOGY." In The All-Russian Scientific Conference with International Participation and Schools of Young Scientists "Mechanisms of resistance of plants and microorganisms to unfavorable environmental". SIPPB SB RAS, 2018. http://dx.doi.org/10.31255/978-5-94797-319-8-1434-1437.
Murillo, Alvaro, Meghan Larin, Emma L. Randall, Alysha Taylor, Mariah Lelos, and Vincent Dion. "I05 CRISPR-Cas9 nickase-mediated gene editing to treat Huntington’s disease." In EHDN 2022 Plenary Meeting, Bologna, Italy, Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jnnp-2022-ehdn.231.
Li, Xi, Wanbing Tang, Chenjie Zhou, Yulin Yang, Zhengang Peng, Wenrong Zhou, Qunsheng Ji, and Yong Cang. "Abstract 785: Application of CRISPR/Cas9 gene editing to primary T cells." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-785.
Zuckermann, Marc, Britta Ismer, Volker Hovestadt, Christiane B. Knobbe-Thomsen, Marc Zapatka, Paul A. Northcott, Martine F. Roussel, et al. "Abstract 5109: Somatic CRISPR/Cas9-mediated gene editing enables versatile brain tumor modeling." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5109.
Sagawa, Cintia. "Identification of HLB Susceptibility Genes in a Citrus Population Generated Using Multiplexed CRISPR/Cas9 Gene Editing." In IS-MPMI Congress. IS-MPMI, 2023. http://dx.doi.org/10.1094/ismpmi-2023-6.
Reports on the topic "Gene Editing (CRISPR/Cas9)":
Young, Erin, Cem Kuscu, Christine Watkins, and Murat Dogan. Using CRISPR Gene Editing to Prevent Accumulation of Lipids in Hepatocytes. University of Tennessee Health Science Center, January 2022. http://dx.doi.org/10.21007/com.lsp.2022.0007.
Morin, S., L. L. Walling, Peter W. Atkinson, J. Li, and B. E. Tabashnik. ets for CRISPR/Cas9-mediated gene drive in Bemisia tabaci. Israel: United States-Israel Binational Agricultural Research and Development Fund, 2021. http://dx.doi.org/10.32747/2021.8134170.bard.
Zarate, Sebastian, Ilaria Cimadori, Maria Mercedes Roca, Michael S. Jones, and Katie Barnhill-Dilling. Assessment of the Regulatory and Institutional Framework for Agricultural Gene Editing via CRISPR-based Technologies in Latin America and the Caribbean. Inter-American Development Bank, May 2023. http://dx.doi.org/10.18235/0004904.
Kuiken, Todd, and Jennifer Kuzma. Genome Editing in Latin America: Regional Regulatory Overview. Inter-American Development Bank, July 2021. http://dx.doi.org/10.18235/0003410.
Bagley, Margo. Genome Editing in Latin America: CRISPR Patent and Licensing Policy. Inter-American Development Bank, July 2021. http://dx.doi.org/10.18235/0003409.
Paran, Ilan, and Allen Van Deynze. Regulation of pepper fruit color, chloroplasts development and their importance in fruit quality. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598173.bard.
Gilkeson, Luke. CRISPR-Cas9 Gene Therapy Review: A Novel Way to Treat Genetic Disease. Ames (Iowa): Iowa State University, May 2024. http://dx.doi.org/10.31274/cc-20240624-452.
Podlevsky, Joshua. Cas9 Protein Post-translational Modifications (PTMs): A Potential Biomarker of Gene-editing. Office of Scientific and Technical Information (OSTI), October 2019. http://dx.doi.org/10.2172/1571552.
Heo, Y., Y. Xu, X. Quan, Y. Seong, N. Kim, and J. Kim. CRISPR/Cas9 nuclease-mediated gene knock-in in bovine pluripotent stem cells and embryos. Cold Spring Harbor Laboratory, May 2014. http://dx.doi.org/10.1101/005421.
Research, Gratis. The Mystery behind Bacterial Retrons. Gratis Research, December 2020. http://dx.doi.org/10.47496/gr.blog.05.