To see the other types of publications on this topic, follow the link: Gender imbalance.

Books on the topic 'Gender imbalance'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 37 books for your research on the topic 'Gender imbalance.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse books on a wide variety of disciplines and organise your bibliography correctly.

1

N, Christofides L. The gender imbalance in participation in Canadian universities (1977-2003). [Guelph, Ont: University of Guelph], 2006.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Musengezi, Chiedza. Words to voices: Gender imbalance in the literary and historical accounts of Zimbabwe. [Zimbabwe: s.n., 2002.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Eileen, Drew, and Murphy Candy, eds. Gender imbalance in Irish civil service grades at Higher Execeutive Officer Level (HEO) and above. Dublin: Institute of Public Administration, 1999.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Cherry, Elizabeth A. Gender perspectives on the causes and consequences of work-life imbalance in the Equality Commission for Northern Ireland. (s.l: The Author), 2003.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Jones, Jo J. Addressing the gender imbalance: An empirical study investigating the success and achievements of boys at Key Stage 2 in English. Birmingham: University of Central England in Birmingham, 1999.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Mnenegwa, Martina P. M. Gender imbalances in Tanzania education administration. Birmingham: University of Birmingham, 1992.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

French, Jane. Gender imbalances in infant school:classroom interaction: Final report to the Equal Opportunities Commission. (s.l.): (s.n.), 1986.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Sharma, Suresh. Progress of school education, gender, and imbalances: The case of Uttarahchal [sic] State in India. Delhi: Institute of Economic Growth, 2006.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

BECK, Stuart. An evaluation of gender imbalances in outdoor pursuits participation BTech (Honours) Leisure and Recreation Management. Ayr: SAC Auchincruive, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

1942-, Mijares Sharon G., ed. The root of all evil: An exposition of prejudice, fundamentalism, and gender imbalance. Exeter, UK: Imprint Academic, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
11

Mijares, Sharon G., Aliaa Rafea, Rachel Falik, and Jenny Eda Schipper. The Root of All Evil: An Exposition of Prejudice, Fundamentalism and Gender Imbalance. Imprint Academic, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
12

Blue school, pink school: Gender imbalance in New York City CTE high schools. NY [i.e. New York City], NY: New York City Public Advocate, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
13

Laurel, Tumarkin, Browne Daniel 1978-, González Isabel, and New York (N.Y.). Office of the Public Advocate., eds. Blue school, pink school: Gender imbalance in New York City CTE high schools. NY [i.e. New York City], NY: New York City Public Advocate, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
14

1942-, Mijares Sharon G., ed. The root of all evil: An exposition of prejudice, fundamentalism, and gender imbalance. Exeter, UK: Imprint Academic, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
15

Das Gupta, Monica. Does Hepatitis B Infection Or Son Preference Explain The Bulk Of Gender Imbalance In China? : A Review Of The Evidence. The World Bank, 2008. http://dx.doi.org/10.1596/1813-9450-4502.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Sheelagh, Drudy, ed. Men and the classroom: Gender imbalances in teaching. by New York: Routledge, 2005.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
17

Kowaleski, Maryanne. Gendering Demographic Change in the Middle Ages. Edited by Judith Bennett and Ruth Karras. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199582174.013.009.

Full text
Abstract:
This essay explores the documentary and skeletal evidence for understanding the relationship between gender and population change in the Middle Ages by focusing on mortality, fertility, and migration. Although cemeteries and historical records both show high sex ratios that imply female supermortality, the explanations offered for this imbalance indicate little consensus, not least because of gender biases in the extant records and in the methods employed to exploit them. Studies of fertility throw a helpful light on gender and population change, even though lack of direct data has forced demographers to develop innovative, if often controversial, ways to understand how fertility worked, through such measures as female age at marriage, proportions of women married, and household size. New techniques such as mitochondrial DNA and isotope analysis show that women migrated over greater distances than did men, while documentary evidence for migration over short distances reveals that women did not always move for the same reasons as men.
APA, Harvard, Vancouver, ISO, and other styles
18

Eto, Mikiko. Women and Political Inequality in Japan: Gender Imbalanced Democracy. Taylor & Francis Group, 2020.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
19

Eto, Mikiko. Women and Political Inequality in Japan: Gender Imbalanced Democracy. Taylor & Francis Group, 2020.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
20

Women and Political Inequality in Japan: Gender Imbalanced Democracy. Taylor & Francis Group, 2020.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
21

Eto, Mikiko. Women and Political Inequality in Japan: Gender Imbalanced Democracy. Taylor & Francis Group, 2020.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
22

Dare to be different: Challenging gender imbalances in modern apprenticeships. Sheffield: DfEE, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
23

Morris, Katherine J. Body Image Disorders. Edited by K. W. M. Fulford, Martin Davies, Richard G. T. Gipps, George Graham, John Z. Sadler, Giovanni Stanghellini, and Tim Thornton. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199579563.013.0037.

Full text
Abstract:
This chapter examines so-called body image disorders, focusing on body dysmorphic disorder, anorexia nervosa, bulimia nervosa, and binge eating disorder. These disorders have been studied extensively by psychologists and psychiatrists from both the "body image" and "body shame" research orientations. Body image disorders have also proved, for feminist thinkers mindful of the gender imbalance in many of these disorders, to be an important locus for cultural criticism, including criticism of psychological and psychiatric perspectives. Those philosophers and anthropologists with a phenomenological bent, particularly those with an interest in the lived body and embodiment, have also found a fruitful terrain in body image disorders. These different disciplines and approaches provide multiple perspectives which are often complementary, occasionally in some tension with one another, but always mutually enriching, and all of them are sketched here.
APA, Harvard, Vancouver, ISO, and other styles
24

Perry, Craig, David Eltis, Stanley L. Engerman, and David Richardson, eds. The Cambridge World History of Slavery. Cambridge University Press, 2021. http://dx.doi.org/10.1017/9781139024723.

Full text
Abstract:
Medieval slavery has received little attention relative to slavery in ancient Greece and Rome and in the early modern Atlantic world. This imbalance in the scholarship has led many to assume that slavery was of minor importance in the Middle Ages. In fact, the practice of slavery continued unabated across the globe throughout the medieval millennium. This volume – the final volume in The Cambridge World History of Slavery – covers the period between the fall of Rome and the rise of the transatlantic plantation complexes by assembling twenty-three original essays, written by scholars acknowledged as leaders in their respective fields. The volume demonstrates the continual and central presence of slavery in societies worldwide between 500 CE and 1420 CE. The essays analyze key concepts in the history of slavery, including gender, trade, empire, state formation and diplomacy, labor, childhood, social status and mobility, cultural attitudes, spectrums of dependency and coercion, and life histories of enslaved people.
APA, Harvard, Vancouver, ISO, and other styles
25

Capone, George T. Down Syndrome. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0056.

Full text
Abstract:
People with Down syndrome (trisomy 21) are distinguished by having an extra copy of chromosome 21. Chromosome 21 contains an estimated 562 genes, including 161 known to code for functional proteins, and at least 396 considered novel. Gene dosage imbalance is the primary mechanism, which results in the molecular, cellular, histological, and anatomical features characteristic of the condition. Throughout brain development, major neurobiological events go awry, resulting in a differently organized brain and characteristic developmental delays noted during infancy and the preschool years. The consequences of gene dosage imbalance continue to have repercussions on neurobiological function throughout childhood and adult life.
APA, Harvard, Vancouver, ISO, and other styles
26

Maunder, Chris, ed. The Oxford Handbook of Mary. Oxford University Press, 2019. http://dx.doi.org/10.1093/oxfordhb/9780198792550.001.0001.

Full text
Abstract:
The Oxford Handbook of Mary includes chapters on textual, literary, and media analysis; theology; Church history; art history; studies on devotion in a variety of forms: liturgy, hymns, homilies, prayer, pilgrimage, lived belief and practice; also cultural history; folk tradition; gender analysis; apparitions; and apocalypticism. These have been contributed by a range of scholars, established names in Marian Studies, writing about Mary the mother of Jesus from within their own expertise. The group is international in scope, from the three countries of North America; various nations in Europe; Jerusalem; Taiwan; Australia. As well as those of no religious affiliation, chapters have been written by Jewish, Muslim, and Christian academics, the last group including priests from within the Eastern Orthodox, Roman Catholic, and Anglican traditions. What is shared between everyone in this diverse group is a commitment to academic rigour as well as a special interest in Mary the mother of Jesus, who is known as the Theotokos, Mother of God. The Handbook looks at both Eastern and Western perspectives and tries to correct imbalance in previous books on Mary towards the West. There is also a chapter on Mary in Islam, and on pilgrimages shared by Christian, Muslim, and Jewish adherents. Mary can be a source of theological disagreement, but the emphasis of this volume is on Mary’s rich potential for inter-faith and inter-denominational dialogue and shared experience.
APA, Harvard, Vancouver, ISO, and other styles
27

Kennedy, John James, and Yaojiang Shi. Lost and Found. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190917425.001.0001.

Full text
Abstract:
Between 1979 and 2010 local leaders and rural families across China concealed the existence of millions of girls from government officials and the national census. The single child policy (1979–2015) was introduced in 1979, and the central government’s goal was to reduce population growth through strict birth control. Yet, at the same time, many rural parents had strong incentives not to comply with the birth control policy because under economic reforms in the 1980s and 1990s, larger families meant increased labor and income. However, most journalists and scholars reported that the combination of a strictly enforced central policy and a historical preference for sons had led to a stark gender imbalance, with an abnormally higher number of males being born than females. The result was an estimated 20 million “missing girls” in the population from 1980 to 2010. Most demographers have believed that this dearth of girls has been due to widespread sex-selective abortion and infanticide. Yet quantitative analysis of China census data and qualitative interviews with rural parents and local leaders suggest that at least half of the “missing girls” were hidden in China. This was due to two key factors. First was the discretion to implement central policy that street-level bureaucrats and local leaders have. There was mutual noncompliance between rural families and village leaders, such that rural parents did not immediately register additional children and local leaders underreported illegal births to higher authorities. Second is the increasing value of daughters and equal preference for sons and daughters over the last several decades.
APA, Harvard, Vancouver, ISO, and other styles
28

Cervin, Georgia. Degrees of Difficulty. University of Illinois Press, 2021. http://dx.doi.org/10.5622/illinois/9780252043772.001.0001.

Full text
Abstract:
This book chronicles the history of Women’s Artistic Gymnastics against the backdrop of the Cold War. Accepted into the Olympic program in 1952 because it was considered uniquely appropriate for women, the sport has always been defined by the performance of femininity. Eastern bloc governments harnessed the nonthreatening nature of gymnasts to advance their political ambitions through citizen diplomacy. Yet at the same time, they were accused of flouting the amateur rule. But this was not the only rule being broken. Some also cheated by score fixing and later, age falsification. The sport became notorious for its young athletes. Their youth contributed to a power imbalance with their coaches, creating the conditions for abuse. Gymnastics was once at the forefront of women’s sport. But can a sport facing these issues, designed to promote a narrow view of gender, really be feminist? In exploring these topics, this book shows how gymnastics became a part of the cultural battlefield for Cold War supremacy. But gymnastics was not only a space for challenge. It also provided moments of international collaboration: between the international gymnastics federation and the International Olympic Committee, between gymnasts, coaches, officials, fans, and even politicians. This book argues that these global interactions charged the transformation of the sport throughout the twentieth century. It offers new insights into how sport transmits and perpetuates social ideals and the role sports, and their governing bodies, play in international relations. And with this knowledge, it suggests how women’s gymnastics might once again become the empowering, feminist experience it once was.
APA, Harvard, Vancouver, ISO, and other styles
29

Local Government National Training Organisation. and Great Britain. Department for Education and Employment., eds. Gender imbalances in modern apprenticeships: A research-based review for the Local Government National Training Organisation and Department for Education and Employment. London: LGNTO, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
30

Morgan, Glyn, and Charul Palmer-Patel, eds. Sideways in Time. Liverpool University Press, 2019. http://dx.doi.org/10.3828/liverpool/9781789620139.001.0001.

Full text
Abstract:
This book is the first collection of scholarly essays on alternate history in over a decade and features contributions from a mixture of major figures and rising stars in the field of science fiction studies. Alternate history is a genre of fiction which, although connected to the genres of utopian, dystopian and science fiction, has its own rich history and lineage. With roots in the writings of ancient Rome, alternate history matured into something close to its current form in the essays and novels of the nineteenth century. In more recent years a number of highly acclaimed novels have been published as alternate histories, by authors ranging from science fiction bestsellers to Pulitzer Prize-winning literary icons. The success and popularity of the genre is reflected in its success on television with original concepts being developed alongside adaptations of iconic texts. This important collection of essays seeks to redress an imbalance between the importance and quality of alternate history texts and the available scholarship and critical readings of texts, providing chapters by both leading scholars in the field and rising stars. The chapters in this book acknowledge the long and distinctive history of the genre whilst also revelling in its vitality, adaptability, and contemporary relevance, with many of the chapters discussing late-twentieth and early-twenty-first century contemporary fiction texts which have received little or no sustained critical analysis elsewhere in print.
APA, Harvard, Vancouver, ISO, and other styles
31

Bentham, James R. The genetics of congenital heart disease. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0022.

Full text
Abstract:
Congenital heart disease (CHD) is defined as a structural cardiac malformation resulting from an abnormality of development; 8% of CHD is inherited in a Mendelian fashion and 12% results from chromosomal imbalance. Recurrence risk and new research suggest that even the remaining 80% of patients without an identifiable familial or syndromic basis for disease may have an identifiable genetic cause. The potential to understand these mechanisms is increasing with the advent of new sequencing techniques which have identified multiple or single rare variants and/or copy number variants clustering in cardiac developmental genes as well as common variants that may also contribute to disease, for example by altering metabolic pathways. Work in model organisms such as mouse and zebrafish has been pivotal in identifying CHD candidate genes. Future challenges involve translating the discoveries made in mouse models to human CHD genetics and manipulating potentially protective pathways to prevent disease.
APA, Harvard, Vancouver, ISO, and other styles
32

Baland, Jean-Marie, and Roberta Ziparo. Intra-Household Bargaining in Poor Countries. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198829591.003.0004.

Full text
Abstract:
This chapter assesses the relevance of the collective model for the analysis of households in poor countries. As an economic unit, a household creates the possibility of mutual gains for spouses thanks to the possibility of joint consumption of public goods, risk sharing, etc. The collective model assumes that households behave efficiently, in the sense that there is no misallocation or waste of household resources, given the outside options of each spouse. This chapter bridges the theoretical literature describing efficient intra-household behaviour and the development literature that collects empirical regularities pointing toward the existence of strategic decision making among spouses. It examines the key elements of the collective model and discusses its relevance to analysing intra-household behaviour in poor countries. It explores the role that risk and uncertainty, information asymmetries, power imbalances, arranged marriages, strategic investment, gender norms, and extended households play in the attainment of efficiency.
APA, Harvard, Vancouver, ISO, and other styles
33

Blyth, Michael. In the Mouth of Madness. Liverpool University Press, 2018. http://dx.doi.org/10.3828/liverpool/9781911325406.001.0001.

Full text
Abstract:
Somewhat overlooked upon its initial release in 1995, John Carpenter's In the Mouth of Madness has since developed a healthy cult reputation. But far more than simply a fan favourite, this closing instalment of the acclaimed director's self-described “apocalypse trilogy” (following The Thing and Prince Of Darkness) stands today as one of his most thematically complex and stylistically audacious pieces of work. The story of an insurance investigator drawn into the supposedly fictional universe of a best-selling horror novelist, the film is an extension of many recurring themes found in Carpenter's filmography (the end of the world, the loss of free will, a distrust of mass industry and global corporations, the cataclysmic resurgence of ancient evil), as well as an affectionate homage to the works of H. P. Lovecraft (and horror literature more broadly) and a self-reflexive celebration of the horror genre that predates the Scream-inspired postmodernist boom of late-nineties genre cinema. While numerous books and countless academic essays have been written about Carpenter's work, surprisingly little has focused exclusively on In the Mouth of Madness, a film which feels more prescient, more essential, and more daringly complex than ever. This book seeks to redress this imbalance, at last positioning this overlooked masterpiece as essential Carpenter.
APA, Harvard, Vancouver, ISO, and other styles
34

Wordsworth, B. P. Skeletal dysplasias. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0150.

Full text
Abstract:
Bone is metabolically active throughout life and metabolic disturbances may have wide-ranging consequences that are not restricted to altering its mechanics. The study of some genetic bone diseases has already provided remarkable insights into the normal regulation of bone metabolism. Skeletal dysplasias are developmental disorders of the chondro-osseous tissues commonly resulting in short stature, which is often disproportionate. The underlying mutations are often in the structural genes encoding components of the matrix but may also involve growth factors or cell signalling. In contrast, the dysostoses tend to affect single bones or groups of bones, reflecting the transient nature of the many different signalling factors to which they are responsive during development. Abnormalities of bone density (high or low) may be due to primary deficiency of bone matrix synthesis (e.g. osteogenesis imperfecta and hypophosphatasia) but may also reflect an imbalance between bone formation and resorption. This may be caused by abnormalities of bone formation (e.g. hyperostosis/sclerosteosis and osteoporosis pseudoglioma syndrome) or bone resorption (e.g. classic osteopetrosis and fibrous dysplasia).
APA, Harvard, Vancouver, ISO, and other styles
35

Stanworth, Simon, and Stuart McKechnie. Pathophysiology of disordered coagulation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0269.

Full text
Abstract:
Imbalances in the regulation of haemostasis may manifest as bleeding (depletion of pro-coagulant factors) or thrombosis (deficiency of anti-coagulants). Disordered haemostasis is common in critically-ill patients and may result from infection, trauma, haemorrhage, inflammation, organ dysfunction (notably renal and liver dysfunction), or drug therapy. Complex patterns of coagulopathy where both bleeding and prothrombotic tendencies co-exist are well recognized in critical illness. The limitations of standard laboratory coagulation tests to predict bleeding risk, including activated partial thromboplastin time and prothrombin time, are well recognized. These assays were developed for diagnosis of inherited bleeding disorders or for monitoring of anticoagulant therapy. This has led to increased interest in global haemostatic tests, such as viscoelastic and thrombin generation tests. Thromboembolism is an important cause of morbidity and mortality in critically-ill patients. While inherited causes of bleeding appear to be often related to single gene abnormalities, thrombotic tendencies appear to reflect more complex interactions between inherited and acquired factors. Many interactions exist between coagulation pathways and inflammation. Systemic inflammation triggers widespread activation of coagulation, with pro-inflammatory cytokines activating pro-coagulant pathways and downregulating anticoagulant pathways. A net result of this interaction between inflammatory and coagulation pathways in sepsis is thrombin generation, intravascular fibrin deposition and a consumptive coagulopathy.
APA, Harvard, Vancouver, ISO, and other styles
36

Nagatomo, Diane Hawley, Kathleen A. Brown, and Melodie L. Cook, eds. Foreign Female English Teachers in Japanese Higher Education: Narratives From Our Quarter. Candlin & Mynard ePublishing Limited, 2020. http://dx.doi.org/10.47908/11.

Full text
Abstract:
The goal of this book is to provide information, inspiration, and mentorship to teachers (namely foreign women, but not restricted to such) as they navigate the gendered waters of teaching English in Japanese higher education. Such a book is timely because foreign female university teachers are outnumbered by their foreign male colleagues by nearly three to one. This imbalance, however, is likely to change as reforms in hiring policies (which have until recently generally favored male applicants) have been widely implemented to encourage more female teachers and researchers. The narratives by the contributors to this book offer a kaleidoscope of experiences that transverse several loosely connected and overlapping themes. This book is, in a sense, a “girlfriend’s guide to teaching in a Japanese university” in that it provides much practical information from those who are already in the field. It covers areas such as gaining entry into Japanese higher education teaching, searching for and obtaining tenure, managing a long-term professorial career, and taking on leadership responsibilities. The personal side of teaching is examined, with authors describing how individual interests have shaped their teaching practices. Family matters, such as negotiating maternity leave, reentering the workforce, and difficulties in balancing family and work are discussed by those who have “been there and done that”. The darker issues of the job, such as harassment, racism, and native-speakerism are introduced, and several chapters with practical and legal information about how to combat them are included, as well as a list of valuable resources. The contributors to this volume have drawn upon their own unique experiences and have situated their stories in areas that are of great personal importance. The individual narratives, when taken together, highlight not only the complexity of the professional identity of EFL teachers but also the myriad of issues that shape the careers of women in Japanese higher education. These issues will resonate with all female EFL faculty, regardless of their geographical location.
APA, Harvard, Vancouver, ISO, and other styles
37

Grant, Warren, and Martin Scott-Brown. Principles of oncogenesis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0322.

Full text
Abstract:
It is obvious that the process of developing cancer—oncogenesis—is a multistep process. We know that smoking, obesity, and a family history are strong independent predictors of developing malignancy; yet, in clinics, we often see that some heavy smokers live into their nineties and that some people with close relatives affected by cancer spend many years worrying about a disease that, in the end, they never contract. For many centuries scientists have struggled to understand the process that make cancer cells different from normal cells. There were those in ancient times who believed that tumours were attributable to acts of the gods. Hippocrates suggested that cancer resulted from an imbalance between the black humour that came from the spleen, and the other three humours: blood, phlegm, and bile. It is only in the last 100 years that biologists have been able to characterize some of the pathways that lead to the uncontrolled replication seen in cancer, and subsequently examine exactly how these pathways evolve. The rampant nature by which cancer invades local and distant tissues, as well its apparent ability to spread between related individuals led some, such as Peyton Rous in 1910, to suggest that cancer was an infectious condition. He was awarded a Nobel Prize in 1966 for the 50 years of work into investigating a link between sarcoma in chickens and a retrovirus that became known as Rous sarcoma virus. He had shown how retroviruses are able to integrate sequences of DNA coding for errors in cellular replication control (oncogenes) by introducing into the human cell viral RNA together with a reverse transcriptase. Viruses are now implicated in many cancers, and in countries where viruses such as HIV and EBV are endemic, the high incidence of malignancies such as Kaposi’s sarcoma and Burkitt’s lymphoma is likely to be directly related. There are several families of viruses associated with cancer, broadly classed into DNA viruses, which mutate human genes using their own DNA, and retroviruses, like Rous sarcoma virus, which insert viral RNA into the cell, where it is then transcribed into genes. This link with viruses has not only led to an understanding that cancer originates from genetic mutations, but has also become a key focus in the design of new anticancer therapies. Traditional chemotherapies either alter DNA structure (as with cisplatin) or inhibit production of its component parts (as with 5-fluorouracil.) These broad-spectrum agents have many and varied side effects, largely due to their non-specific activity on replicating DNA throughout the body, not just in tumour cells. New vaccine therapies utilizing gene-coding viruses aim to restore deficient biological pathways or inhibit mutated ones specific to tumour cells. The hope is that these gene therapies will be effective and easily tolerated by patients, but development is currently progressing with caution. In a trial in France of ten children suffering from X-linked severe combined immunodeficiency and who were injected with a vector that coded for the gene product they lacked, two of the children subsequently died from leukaemia. Further analysis confirmed that the DNA from the viral vector had become integrated into an existing, but normally inactive, proto-oncogene, LM02, triggering its conversion into an active oncogene, and the development of life-threatening malignancy. To understand how a tiny change in genetic structure could lead to such tragic consequences, we need to understand the molecular biology of the cell and, in particular, to pay attention to the pathways of growth regulation that are necessary in all mammalian cell populations. Errors in six key regulatory pathways are known as the ‘hallmarks of cancer’ and will be discussed in the rest of this chapter.
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography