Journal articles on the topic 'GATOR1 complex'
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Kurrle, Nina, Frank Schnütgen, Juliana Heidler, Ina Poser, Frank Wempe, Diego Yepes, Ilka Wittig, et al. "Exploring the Function of Sestrin/Gator As Novel Regulators of Hematopoiesis." Blood 128, no. 22 (December 2, 2016): 1484. http://dx.doi.org/10.1182/blood.v128.22.1484.1484.
Full textMuller, Maéline, Jasmine Bélanger, Imane Hadj-Aissa, Conghao Zhang, Chantelle F. Sephton, and Paul A. Dutchak. "GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1." International Journal of Molecular Sciences 25, no. 4 (February 8, 2024): 2068. http://dx.doi.org/10.3390/ijms25042068.
Full textWei, Youheng, Brad Reveal, Weili Cai, and Mary A. Lilly. "The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster." G3 Genes|Genomes|Genetics 6, no. 12 (December 1, 2016): 3859–67. http://dx.doi.org/10.1534/g3.116.035337.
Full textVan ’t Hof, Femke, and Eva Brilstra. "Focale epilepsie en de GATOR1 complex genen." Epilepsie, periodiek voor professionals 19, no. 2 (June 1, 2021): 11–13. http://dx.doi.org/10.54160/epilepsie.11027.
Full textGu, Xin, Jose M. Orozco, Robert A. Saxton, Kendall J. Condon, Grace Y. Liu, Patrycja A. Krawczyk, Sonia M. Scaria, J. Wade Harper, Steven P. Gygi, and David M. Sabatini. "SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway." Science 358, no. 6364 (November 9, 2017): 813–18. http://dx.doi.org/10.1126/science.aao3265.
Full textPadi, Sathish K. R., Neha Singh, Jeremiah J. Bearss, Virginie Olive, Jin H. Song, Marina Cardó-Vila, Andrew S. Kraft, and Koichi Okumura. "Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth." Proceedings of the National Academy of Sciences 116, no. 41 (September 23, 2019): 20505–10. http://dx.doi.org/10.1073/pnas.1904774116.
Full textBaldassari, Sara, Laura Licchetta, Paolo Tinuper, Francesca Bisulli, and Tommaso Pippucci. "GATOR1 complex: the common genetic actor in focal epilepsies." Journal of Medical Genetics 53, no. 8 (May 19, 2016): 503–10. http://dx.doi.org/10.1136/jmedgenet-2016-103883.
Full textSolanki, Sumeet, Jun-Hee Lee, and Yatrik Shah. "AMINO ACID SENSING PATHWAYS IN INFLAMMATORY BOWEL DISEASE." Inflammatory Bowel Diseases 28, Supplement_1 (January 22, 2022): S23—S24. http://dx.doi.org/10.1093/ibd/izac015.036.
Full textNada, Shigeyuki, and Masato Okada. "Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1." Journal of Biochemistry 168, no. 6 (July 11, 2020): 621–32. http://dx.doi.org/10.1093/jb/mvaa076.
Full textKorenke, Georg-Christoph, Marlene Eggert, Holger Thiele, Peter Nürnberg, Thomas Sander, and Ortrud K. Steinlein. "Nocturnal frontal lobe epilepsy caused by a mutation in the GATOR1 complex geneNPRL3." Epilepsia 57, no. 3 (January 20, 2016): e60-e63. http://dx.doi.org/10.1111/epi.13307.
Full textKrenn, Martin, Matias Wagner, Christoph Hotzy, Elisabeth Graf, Sandrina Weber, Theresa Brunet, Bettina Lorenz-Depiereux, et al. "Diagnostic exome sequencing in non-acquired focal epilepsies highlights a major role of GATOR1 complex genes." Journal of Medical Genetics 57, no. 9 (February 21, 2020): 624–33. http://dx.doi.org/10.1136/jmedgenet-2019-106658.
Full textSmieszek, S. P. "0018 Whole Genome Sequencing Study Identifies Novel Variants Associated with Intrinsic Circadian Period in Humans." Sleep 43, Supplement_1 (April 2020): A7—A8. http://dx.doi.org/10.1093/sleep/zsaa056.017.
Full textMeng, Jin, and Shawn M. Ferguson. "GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids." Journal of Cell Biology 217, no. 8 (May 30, 2018): 2765–76. http://dx.doi.org/10.1083/jcb.201712177.
Full textFiglia, Gianluca, Sandra Müller, Anna M. Hagenston, Susanne Kleber, Mykola Roiuk, Jan-Philipp Quast, Nora ten Bosch, et al. "Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition." Nature Cell Biology 24, no. 9 (September 2022): 1407–21. http://dx.doi.org/10.1038/s41556-022-00977-x.
Full textDawson, Ruby E., Alvaro F. Nieto Guil, Louise J. Robertson, Sandra G. Piltz, James N. Hughes, and Paul Q. Thomas. "Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy." Neurobiology of Disease 134 (February 2020): 104640. http://dx.doi.org/10.1016/j.nbd.2019.104640.
Full textSahly, Ahmed N., Robyn Whitney, Gregory Costain, Vann Chau, Hiroshi Otsubo, Ayako Ochi, Elizabeth J. Donner, et al. "Epilepsy surgery outcomes in patients with GATOR1 gene complex variants: Report of new cases and review of literature." Seizure 107 (April 2023): 13–20. http://dx.doi.org/10.1016/j.seizure.2023.03.004.
Full textCheng, Yang, Jiadong Cai, Yuanyuan Fu, Congjing Feng, Yue Hao, and Youheng Wei. "Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity." Biology Open 9, no. 11 (October 9, 2020): bio054999. http://dx.doi.org/10.1242/bio.054999.
Full textImanaga, Hiroshi, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Tatsuya Terasaki, Fumihiko Nakao, et al. "A Genome-Wide CRISPR-Cas9 Screen Reveals GATOR1 Complex Is a Critical Regulator of Glucocorticoid Sensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia." Blood 140, Supplement 1 (November 15, 2022): 5979. http://dx.doi.org/10.1182/blood-2022-164647.
Full textBecchetti, Andrea, Laura Clara Grandi, Giulia Colombo, Simone Meneghini, and Alida Amadeo. "Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology." Brain Sciences 10, no. 12 (November 25, 2020): 907. http://dx.doi.org/10.3390/brainsci10120907.
Full textSharma, Vijendra, Rapita Sood, Danning Lou, Tzu-Yu Hung, Maxime Lévesque, Yelin Han, Jeremy Y. Levett, et al. "4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold." Proceedings of the National Academy of Sciences 118, no. 15 (April 5, 2021): e2025522118. http://dx.doi.org/10.1073/pnas.2025522118.
Full textNabavi Nouri, Maryam, Lama Alandijani, Kalene van Engelen, Soumitra Tole, Emilie Lalonde, and Tugce B. Balci. "From Alpha-Thalassemia Trait to NPRL3-Related Epilepsy: A Genomic Diagnostic Odyssey." Genes 15, no. 7 (June 25, 2024): 836. http://dx.doi.org/10.3390/genes15070836.
Full textLemke, Johannes R. "Commentary: GATOR Complex-Associated Epilepsies." Epilepsia 58, no. 7 (June 14, 2017): 1121–22. http://dx.doi.org/10.1111/epi.13789.
Full textLoissell-Baltazar, Yahir A., and Svetlana Dokudovskaya. "SEA and GATOR 10 Years Later." Cells 10, no. 10 (October 8, 2021): 2689. http://dx.doi.org/10.3390/cells10102689.
Full textKowalsky, Allison Ho, Sim Namkoong, Eric Mettetal, Hwan-Woo Park, Dubek Kazyken, Diane C. Fingar, and Jun Hee Lee. "The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation." Journal of Biological Chemistry 295, no. 7 (January 8, 2020): 1769–80. http://dx.doi.org/10.1074/jbc.ra119.010857.
Full textXu, Dandan, Kevin L. Shimkus, Holly A. Lacko, Lydia Kutzler, Leonard S. Jefferson, and Scot R. Kimball. "Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 316, no. 5 (May 1, 2019): E817—E828. http://dx.doi.org/10.1152/ajpendo.00522.2018.
Full textParmigiani, Anita, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, and Andrei V. Budanov. "Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex." Cell Reports 9, no. 4 (November 2014): 1281–91. http://dx.doi.org/10.1016/j.celrep.2014.10.019.
Full textSteiner, Laurie. "Helping GATA1 make complex decisions." Blood 139, no. 24 (June 16, 2022): 3457–59. http://dx.doi.org/10.1182/blood.2022016347.
Full textJang, Ki Beom, Agus Suryawan, Marta L. Fiorotto, and Teresa A. Davis. "PSII-18 Prematurity alters nutrient signaling and protein synthesis in skeletal muscle of neonatal piglets." Journal of Animal Science 102, Supplement_3 (September 1, 2024): 694–95. http://dx.doi.org/10.1093/jas/skae234.783.
Full textKadauke, Stephan, Amy E. Campbell, Aaron J. Stonestrom, Deepti P. Jain, Ross C. Hardison, and Gerd A. Blobel. "GATA1 and the BET Family Protein Brd3 Form a Mitotic Bookmarking Complex." Blood 120, no. 21 (November 16, 2012): 282. http://dx.doi.org/10.1182/blood.v120.21.282.282.
Full textHesketh, Geoffrey G., Fotini Papazotos, Judy Pawling, Dushyandi Rajendran, James D. R. Knight, Sebastien Martinez, Mikko Taipale, Daniel Schramek, James W. Dennis, and Anne-Claude Gingras. "The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids." Science 370, no. 6514 (October 15, 2020): 351–56. http://dx.doi.org/10.1126/science.aaz0863.
Full textHamlett, Isla, Julia Draper, John Strouboulis, Francisco Iborra, Catherine Porcher, and Paresh Vyas. "Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation." Blood 112, no. 7 (October 1, 2008): 2738–49. http://dx.doi.org/10.1182/blood-2008-03-146605.
Full textKaminaga, Chihiro, Shumpei Mizuta, Tomoya Minami, Kasumi Oda, Haruka Fujita, Keiji Matsui, Ruri Ishino, Akiko Sumitomo, Norinaga Urahama, and Mitsuhiro Ito. "CoCoA/CCAR1 Pair-Mediated Recruitment of Mediator Complex Indicates Novel Pathway for the Function of GATA1 in Erythroid Differentiation." Blood 118, no. 21 (November 18, 2011): 1302. http://dx.doi.org/10.1182/blood.v118.21.1302.1302.
Full textVarricchio, Lilian, Carmela Dell'Aversana, Angela Nebbioso, Giovanni Migliaccio, Lucia Altucci, James J. Bieker, and Anna Rita F. Migliaccio. "Identification of a New Functional HDAC Complex Composed by HDAC5, GATA1 and EKLF in Human Erythroid Cells." Blood 120, no. 21 (November 16, 2012): 979. http://dx.doi.org/10.1182/blood.v120.21.979.979.
Full textWeckhuysen, Sarah, Elise Marsan, Virginie Lambrecq, Cécile Marchal, Mélanie Morin-Brureau, Isabelle An-Gourfinkel, Michel Baulac, et al. "Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia." Epilepsia 57, no. 6 (May 13, 2016): 994–1003. http://dx.doi.org/10.1111/epi.13391.
Full textLaufenberg, Lacee J., Kristen T. Crowell, and Charles H. Lang. "Alcohol Acutely Antagonizes Refeeding-Induced Alterations in the Rag GTPase-Ragulator Complex in Skeletal Muscle." Nutrients 13, no. 4 (April 9, 2021): 1236. http://dx.doi.org/10.3390/nu13041236.
Full textNishikawa, Keizo, Makoto Kobayashi, Atsuko Masumi, Susan E. Lyons, Brant M. Weinstein, P. Paul Liu, and Masayuki Yamamoto. "Self-Association of Gata1 Enhances Transcriptional Activity In Vivo in Zebra Fish Embryos." Molecular and Cellular Biology 23, no. 22 (November 15, 2003): 8295–305. http://dx.doi.org/10.1128/mcb.23.22.8295-8305.2003.
Full textDrissen, Roy, Boris Guyot, Lin Zhang, Ann Atzberger, Jackie Sloane-Stanley, Bill Wood, Catherine Porcher, and Paresh Vyas. "Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression." Blood 115, no. 17 (April 29, 2010): 3463–71. http://dx.doi.org/10.1182/blood-2009-07-232876.
Full textFreson, Kathleen, Koen Devriendt, Gert Matthijs, Achiel Van Hoof, Rita De Vos, Chantal Thys, Kristien Minner, Marc F. Hoylaerts, Jos Vermylen, and Chris Van Geet. "Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1mutation." Blood 98, no. 1 (July 1, 2001): 85–92. http://dx.doi.org/10.1182/blood.v98.1.85.
Full textWang, Yuhuan, Ronghua Meng, Vincent Hayes, Rudy Fuentes, Xiang Yu, Charles S. Abrams, Harry F. G. Heijnen, Gerd A. Blobel, Michael S. Marks, and Mortimer Poncz. "Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction." Blood 118, no. 23 (December 1, 2011): 6183–91. http://dx.doi.org/10.1182/blood-2011-06-363580.
Full textKelly, Soady, Gaëtan Juban, Ludovic Lhermitte, Elena Karkoulia, John Strouboulis, Irene Roberts, and Paresh Vyas. "Cellular and Molecular Basis of Mutant Haemopoietic Transcription Factor GATA1s." Blood 124, no. 21 (December 6, 2014): 607. http://dx.doi.org/10.1182/blood.v124.21.607.607.
Full textMishima, Yuta, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, and Atsushi Iwama. "The Hbo1-Brd1/Brpf2 HAT Complex Is Required for Erythropoiesis In Fetal Liver." Blood 116, no. 21 (November 19, 2010): 3872. http://dx.doi.org/10.1182/blood.v116.21.3872.3872.
Full textSuryawan, Agus, Marko Rudar, Marta L. Fiorotto, and Teresa A. Davis. "Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigs." Journal of Applied Physiology 128, no. 2 (February 1, 2020): 286–95. http://dx.doi.org/10.1152/japplphysiol.00332.2019.
Full textDoty, Raymond T., Xiaowei Yan, Christopher Lausted, Adam D. Munday, Zhantao Yang, Danielle Yi, Neda Jabbari, et al. "Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation." Blood 133, no. 5 (January 31, 2019): 457–69. http://dx.doi.org/10.1182/blood-2018-05-850412.
Full textDrissen, Roy, Boris Guyot, William Wood, Catherine Porcher, and Paresh Vyas. "Characterisation Erythroid-Specific Cis-Elements Regulating the Key Transcription Factor GATA1." Blood 108, no. 11 (November 16, 2006): 1167. http://dx.doi.org/10.1182/blood.v108.11.1167.1167.
Full textWagenblast, Elvin, Olga I. Gan, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, Lorien Shakib, Jessica L. McLeod, et al. "Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution." Blood 134, Supplement_1 (November 13, 2019): 2531. http://dx.doi.org/10.1182/blood-2019-129259.
Full textCampbell, Amy E., Lorna Wilkinson-White, Joel P. Mackay, Jacqueline M. Matthews, and Gerd A. Blobel. "Dissecting the Molecular Pathways That Underlie Disease-Causing GATA1 Mutations." Blood 120, no. 21 (November 16, 2012): 3439. http://dx.doi.org/10.1182/blood.v120.21.3439.3439.
Full textChen, Jian, Yue Li, Fouad Yousif, Sagi Abelson, Sanaz Manteghi, John D. McPherson, and Johann K. Hitzler. "Postnatally Acquired Mutations Underlie the Progression of Transient Leukemia to Myeloid Leukemia of Down Syndrome." Blood 132, Supplement 1 (November 29, 2018): 442. http://dx.doi.org/10.1182/blood-2018-99-117198.
Full textChiu, Sung K., Stephanie L. Orive, Mitchell J. Moon, Jesslyn Saw, Sarah Ellis, Benjamin T. Kile, Yizhou Huang, et al. "Shared roles for Scl and Lyl1 in murine platelet production and function." Blood 134, no. 10 (September 5, 2019): 826–35. http://dx.doi.org/10.1182/blood.2019896175.
Full textVagapova, E. R., P. V. Spirin, T. D. Lebedev, and V. S. Prassolov. "The Role of TAL1 in Hematopoiesis and Leukemogenesis." Acta Naturae 10, no. 1 (March 15, 2018): 15–23. http://dx.doi.org/10.32607/20758251-2018-10-1-15-23.
Full textGregory, Gregory D., Annarita Miccio, Alexey Bersenev, Yuhuan Wang, Wei Hong, Zhe Zhang, Mortimer Poncz, Wei Tong, and Gerd A. Blobel. "FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment." Blood 115, no. 11 (March 18, 2010): 2156–66. http://dx.doi.org/10.1182/blood-2009-10-251280.
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