Academic literature on the topic 'GATOR1 complex'
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Journal articles on the topic "GATOR1 complex"
Kurrle, Nina, Frank Schnütgen, Juliana Heidler, Ina Poser, Frank Wempe, Diego Yepes, Ilka Wittig, et al. "Exploring the Function of Sestrin/Gator As Novel Regulators of Hematopoiesis." Blood 128, no. 22 (December 2, 2016): 1484. http://dx.doi.org/10.1182/blood.v128.22.1484.1484.
Full textMuller, Maéline, Jasmine Bélanger, Imane Hadj-Aissa, Conghao Zhang, Chantelle F. Sephton, and Paul A. Dutchak. "GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1." International Journal of Molecular Sciences 25, no. 4 (February 8, 2024): 2068. http://dx.doi.org/10.3390/ijms25042068.
Full textWei, Youheng, Brad Reveal, Weili Cai, and Mary A. Lilly. "The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster." G3 Genes|Genomes|Genetics 6, no. 12 (December 1, 2016): 3859–67. http://dx.doi.org/10.1534/g3.116.035337.
Full textVan ’t Hof, Femke, and Eva Brilstra. "Focale epilepsie en de GATOR1 complex genen." Epilepsie, periodiek voor professionals 19, no. 2 (June 1, 2021): 11–13. http://dx.doi.org/10.54160/epilepsie.11027.
Full textGu, Xin, Jose M. Orozco, Robert A. Saxton, Kendall J. Condon, Grace Y. Liu, Patrycja A. Krawczyk, Sonia M. Scaria, J. Wade Harper, Steven P. Gygi, and David M. Sabatini. "SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway." Science 358, no. 6364 (November 9, 2017): 813–18. http://dx.doi.org/10.1126/science.aao3265.
Full textPadi, Sathish K. R., Neha Singh, Jeremiah J. Bearss, Virginie Olive, Jin H. Song, Marina Cardó-Vila, Andrew S. Kraft, and Koichi Okumura. "Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth." Proceedings of the National Academy of Sciences 116, no. 41 (September 23, 2019): 20505–10. http://dx.doi.org/10.1073/pnas.1904774116.
Full textBaldassari, Sara, Laura Licchetta, Paolo Tinuper, Francesca Bisulli, and Tommaso Pippucci. "GATOR1 complex: the common genetic actor in focal epilepsies." Journal of Medical Genetics 53, no. 8 (May 19, 2016): 503–10. http://dx.doi.org/10.1136/jmedgenet-2016-103883.
Full textSolanki, Sumeet, Jun-Hee Lee, and Yatrik Shah. "AMINO ACID SENSING PATHWAYS IN INFLAMMATORY BOWEL DISEASE." Inflammatory Bowel Diseases 28, Supplement_1 (January 22, 2022): S23—S24. http://dx.doi.org/10.1093/ibd/izac015.036.
Full textNada, Shigeyuki, and Masato Okada. "Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1." Journal of Biochemistry 168, no. 6 (July 11, 2020): 621–32. http://dx.doi.org/10.1093/jb/mvaa076.
Full textKorenke, Georg-Christoph, Marlene Eggert, Holger Thiele, Peter Nürnberg, Thomas Sander, and Ortrud K. Steinlein. "Nocturnal frontal lobe epilepsy caused by a mutation in the GATOR1 complex geneNPRL3." Epilepsia 57, no. 3 (January 20, 2016): e60-e63. http://dx.doi.org/10.1111/epi.13307.
Full textDissertations / Theses on the topic "GATOR1 complex"
Pan, Zhenrui. "Functional characterization of the GATOR1 complex in cisplatin resistance." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL053.
Full textCisplatin administration is the primary chemotherapy approach for many epithelial cancers. However, resistance to this drug poses a significant challenge to effective treatment. Despite the identification of numerous factors associated with drug resistance, reliable biomarkers predicting drug response remain elusive. Previously, low expression of the tumor suppressor NPRL2 was linked to cisplatin resistance. NPRL2, along with NPRL3 and DEPDC5, forms the GATOR1 complex, an upstream regulator of the mTOR complex 1, the function of which is perturbed in many cancers, particularly those resistant to cisplatin.Here, we compare non-cancerous bronchial epithelium BEAS-2B cells with GATOR1 deletions, serving as a model of intrinsic cisplatin resistance, with non-small cell lung cancer lines A549, H460, H1975 with acquired resistance to the drug. We found that depletion of any GATOR1 member, not solely NPRL2, promotes cisplatin resistance whereas their overexpression renders cells sensitive to the drug. In the cells with GATOR1 depletions, expression of the transporter ATP7A required for cisplatin efflux is increased while expression of cisplatin influx transporters CTR2 and LRCC8A is downregulated, especially after treatment with the drug. This hinders drug accumulation in cells, resulting in the formation of fewer cisplatin-DNA adducts. Simultaneously, these cells exhibit enhanced DNA damage response and mTORC1 activity. Overexpression of GATOR1 components and/or concomitant treatment with mTORC1 inhibitors restores sensitivity to cisplatin. Transcriptomic analysis of GATOR1-depleted BEAS-2B cells, treated or not with the drug, identifies new signatures important for understanding GATOR1 function and its role in cisplatin resistance. Thus, GATOR1 not only participates in the cellular response to the amino acid availability, but also plays a role in resistance to DNA-damaging anticancer drugs. This novel function of GATOR1 should be taken into account when developing new strategies to combat chemoresistance
Ma, Yinxing. "Functional characterization of tumor suppressors from the SEA / GATOR complex." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS275.
Full textThe major signaling pathway that regulates cell growth and metabolism is under the control of the mechanistic target of rapamycin complex 1 (mTORC1). One of the mTORC1 upstream regulators involved in amino acid sensing and autophagy is called the SEA complex in yeast and GATOR in mammalian cells. Several GATOR components are deregulated in many cancers and neurodegenerative diseases. Despite of the growing interest to the SEA/GATOR, many details concerning its function and implication in different human disorders are still unknown.The main objective of my thesis was to extend our knowledge about the SEA/GATOR, especially what concerns its role in the modulating cellular signaling network. Because the SEA/GATOR is highly conserved I performed the experiments using two model systems - budding yeast S. cerevisiae and human cells lines. The results I obtained allowed to demonstrate a new role for the GATOR component NPRL2, distinct from its function in mTORC1 regulation. We found that ectopic expression of NPRL2 induces oxidative stress and leads to the DNA damage and apoptosis. The studies in yeast revealed that the SEA complex connects the TORC1 pathway and the regulation of mitochondria quality control. Therefore, the SEA/GATOR complex is emerging as a multifunctional regulator of several cellular processes
Gonzalez, Alba. "On the edge between cell division and differentiation : role of Seh1 in mouse embryonic stem cells." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7039.
Full textThe nuclear pore complexes (NPCs) are large macromolecular structures embedded in the nuclear envelope, composed of around 30 different proteins called nucleoporins or Nups. Besides their function in regulating nucleo-cytoplasmic transport, several Nups have been reported to play essential roles in other unrelated processes such as chromatin organization, gene regulation, cell cycle control and cell differentiation. The Nup107 complex (also termed Y-complex) is the major structural component of the NPC and is composed of 9 distinct Nups. The Y-complex has been shown to also localize at kinetochores, where it contributes to cell cycle progression. Moreover, one of the components of the Y-complex, Nup133, is required for embryonic stem cell differentiation and proper mouse development. More recent data further indicated a function of Nup133 in the assembly of the nuclear pore basket that may underlie some of its functions. The Y-complex has thus appeared as a key player in multiple biological processes. However, the specific roles of each of its subunits have just started to be investigated. Among the subunits of the Y-complex, Seh1 has been previously reported to play a role in chromosome alignment and segregation in cancer cell lines, by recruiting the Y-complex and several key mitotic regulators (including notably Aurora B) to kinetochores. Interestingly, Seh1 also belongs to the unrelated GATOR2 complex, an essential activator of the mTORC1 kinase, a master regulator of cell growth and proliferation. It is however unknown whether the mitotic functions of Seh1 rely on its localization at the pore, at kinetochores, or the GATOR2-complex. Due to the increasing number of studies implicating nuclear pore components in regulatory processes, Seh1 appears as a good candidate for the coordination of cell cycle and possibly differentiation. My data has revealed that Seh1-/- mESCs are viable in pluripotent state, but that cell survival is severely impaired upon differentiation. Pluripotent Seh1-/- mESCs also feature a cell growth rate delay when in the pluripotent state, correlated with a small (10 min) mitotic delay and and lenghthening of the interphase lenght as compared to WT mESCs. In contrast to previous studies performed in HeLa cells, we observed that both the Y-complex and Aurora B are still properly targeted to kinetochores in these cells. To understand if this delay is due to a role at NPCs or within the GATOR2 complex, I designed a strategy to specifically impair the interaction between Seh1 and Nup85 (∆N-Nup85), its direct partner within the Y-complex. In the resulting ∆N-Nup85 mutants, Seh1 is no longer detectable at kinetochores and is largely mislocalized from the NPC. In parallel, I constitutively inactivated Mios, another member of the GATOR2 complex. Surprisingly, the resulting ∆N-Nup85 and Mios-/- cells did progress through differentiation and no cell growth delay was observed. Interestingly, we observed an unexpected decrease in NPC density in the Seh1-/- and ∆N-Nup85 mESCs that was in contrast not observed in the Mios-/-cells. This pointed to a function of Seh1 in the context of the Y-complex in the regulation of NPC assembly.We also observed a reduction in nuclear size in the Seh1 mutants that is not shared by the ∆-Nup85mutants but that could be consistent with a role of Seh1 within the GATOR2 complex. My research has expanded our knowledge regarding the different roles of Seh1 and has started to tease apart the relative contributions of this protein in its different subcellular contexts
Bazzi, Talissa. "CARACTERÍSTICAS CLÍNICO-EPIDEMIOLÓGICAS, HISTOMORFOLÓGICAS E HISTOQUÍMICAS DA ESPOROTRICOSE FELINA." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/10218.
Full textSporotricosis is an acute or subacute mycotic infection caused by the Sporothrix complex species. The disease was already described in humans and in several animal species, mostly in cats, horses and dogs. Based on several outbreak reports in the literature, the species more predominant in cats of the Southeast and South regions of Brazil is S. brasiliensis. The transmission to humans include the occupational and the zoonotic forms. The presentation form more often seen in cats is multiple skin and mucosal lesions. The diagnostic methods include the isolation and identification of the agente in culture, the histopathology, the cytology, the intradermal sporotrichin test, the immunohistochemistry technique, and the polymerase chain reaction (PCR). The histopathological diagnosis is based on the morphological characteristics of the fungus and the respective inflammatory reaction. The main objectives of this retrospective study were to characterize the histomorphological and histochemical aspects of sporotrichosis in 10 cats, and also to evaluate epidemiological and clinical aspects, and gross findings obtained from the biopsy and necropsy protocols of the archives of the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria. The disease affected mostly male mongrel cats, and was mostly observed in the cutaneous disseminated form. Gross lesions were characterized by cutaneous nodules (ulcerated or not) and by ulcerated masses or plaques. By histopathology, there were a relationship between the fungal load and two patterns of inflammatory response. The first pattern was characterized by high fungal load, and most yeasts were inside of numerous macrophages with abundant, many times vacuolated cytoplasm. The amount of neutrophils ranged from mild to moderate in this pattern. The second pattern was characterized by numerous epiteliod cells and many neutrophils. The fungal load was low and most yeasts were observed in the extracellular space. The yeasts were round, oval or cigar-shaped. Several histochemical techniques, such as Grocott s silver stain, periodic Schiff acid, and Alcian blue were utilized and they made it easier to visualize, to characterize the morphology, and to quantify the organisms. The Giemsa stain allowed visualizing the agent, but it not allowed to sharply highlight them from other intralesional components. Organisms were negative for melanin granules through the Fontana-Masson stain in all cases. The histomorphological and histochemical study allowed demonstrating determinant fungal characteristics to the establishment of the diagnosis by means of this diagnostic tool.
Esporotricose é uma infecção fúngica subaguda ou crônica, causada por espécies do complexo Sporothrix. A doença já foi descrita em humanos e em diversas espécies animais, mas ocorre com maior frequência em gatos, cavalos e cães. Baseado em vários relatos de surtos na literatura, a espécie mais predominante em gatos das regiões Sul e Sudeste do Brasil é S. brasiliensis. As formas de transmissão para humanos incluem a ocupacional e a zoonótica. A forma de apresentação mais frequente em gatos é de múltiplas lesões de pele e mucosas. Os métodos de diagnóstico compreendem o isolamento e identificação do agente em cultura, a histopatologia, a citologia, o teste intradérmico da esporotriquina, a técnica de imuno-histoquímica (IHQ) e a reação em cadeia de polimerase (PCR). O diagnóstico histopatológico é realizado observando-se as características morfológicas do fungo e a respectiva reação inflamatória. Os principais objetivos deste estudo retrospectivo foram caracterizar os aspectos histomorfológicos e histoquímicos da esporotricose em 10 gatos, além de avaliar os aspectos epidemiológicos, clínicos e os achados macroscópicos obtidos dos protocolos de biópsias e necropsias dos arquivos do Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria. A doença afetou predominantemente gatos machos, sem raça definida e na forma cutânea disseminada. As lesões macroscópicas caracterizaram-se como nódulos cutâneos (ulcerados ou não) e como massas e placas ulceradas. Na histopatologia observou-se uma relação entre a quantidade de leveduras observada e dois padrões de resposta inflamatória. O primeiro padrão caracterizou-se por numerosas leveduras encontradas, na sua maioria, no interior de numerosos macrófagos com citoplasma abundante e muitas vezes vacuolizado. A quantidade de neutrófilos variava de leve a moderada e havia infiltrado geralmente leve de linfócitos e plasmócitos. O segundo padrão caracterizava-se por leve quantidade de leveduras observadas geralmente livres no espaço extracelular, numerosas células epitelioides e infiltrado predominantemente acentuado de neutrófilos. As leveduras eram redondas, ovais ou alongadas (em forma de charuto). Foram utilizadas várias técnicas histoquímicas como a impregnação pela prata de Grocott, ácido periódico de Schiff e azul Alciano que facilitaram a visualização, caracterização da morfologia e quantificação dos organismos. A coloração de Giemsa permitiu a visualização do agente, porém não permitiu destacá-los dos debris celulares. Os organismos foram negativos para grânulos de melanina pela coloração de Fontana-Masson em todos os casos. O estudo histomorfológico e histoquímico permitiu demonstrar características fúngicas determinantes para o estabelecimento do diagnóstico de esporotricose através dessa ferramenta diagnóstica.
Oikonomopoulos, Spyridon. "Inferring structural properties of protein-DNA binding using high-throughput sequencing : the paradigm of GATA1, KLF1 and their complexes GATA1/FOG1 and GATA1/KLF1 : insights into the transcriptional regulation of the erythroid cell lineage." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:72b92906-4ef6-4c1d-9155-484521027e2e.
Full textVargas, Zúñiga Juan Alberto. "Reporte de un caso de epidermitis supurativa necrótica por Acinetobacter calcoaceticus - Acinetobacter baumannii (Acb-) complex en gato (Felis catus) en el Perú." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2017. https://hdl.handle.net/20.500.12672/11379.
Full textTrabajo académico
Seki, Meire Christina [UNESP]. "Chlamydophila felis em gatos (Felis catus): detecção de antígeno e pesquisa de anticorpos." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/95975.
Full textFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O presente trabalho, primeiro estudo sobre clamidiose felina no Brasil, teve o objetivo de pesquisar a presença direta e indireta de Chlamydophila (elis em gatos domésticos provenientes de cinco municípios da região nordeste do estado de São Paulo. Adicionalmente, correlacionar os dados de ficha clínica com os resultados positivos obtidos nos três testes laboratoriais utilizados, ou seja, reação em cadeia pela polimerase (PCR), reação de imunotluorescência indireta (RI FI) e reação de fixação do complemento (RFC). O grupo experimental final foi constituído de 151 animais, dos quais 73 eram provenientes de gatis, 18 de clínica/hospitais veterinários e 60 de abrigos públicos para animais. Das 151 amostras de suabes de conjuntiva submetidas à PCR, em 6,0% (9/151) foi encontrado DNA de C. (elis. Anticorpos anti-Chlamydiaceae foram detectados em 72,1% (106/147) das amostras de soros submetidas à RIFI. Em somente 9,4% (10/106) dos soros positivos à RIFI, foram detectados anticorpos fixadores do complemento, revelando que a RFC, embora específica, apresenta baixa sensibilidade quando utilizada na pesquisa de anticorpos anti-Chlamydiaceae em gatos domésticos. Foi também observado que gatos provenientes de gatis, animais com idade maior que um ano e inferior a seis anos, bem como as fêmeas, estão mais predispostos a soroprevalência para C.felis pela RIFI. Entretanto, tais resultados não foram observados nos animais PCR positivo. Ademais, pode-se verificar uma estreita relação entre as presenças de DNA clamidial e de anticorpos anti-Chlamydiaceae em gatos domésticos brasileiros aos dados das fichas clínica relacionados à doença do trato respiratório superior, a secreção ocular e a conjuntivite.
This work, first study about feline chlamydiosis in Brazil, had the objective to evaluate the direct and indirect presence to Chlamydophila felis in domestic cats coming trom tive cities of northeast of São Paulo state. Additionally, relate informations of clinical records with positives results get in the three laboratories tests used, whatever, complement fixation test (CFT), immunofluorescende assay (IFI) and Polymerase Chain Reaction (PCR). Experimental group had 151 animais, witch 73 coming from catteries, 18 coming trom veterinary clinicallhospital and 60 coming from public animal shelters. From 151 samples of conjunctival swabs submitled to PCR, in 6% (9/151) were detect DNA of C.felis. Anti-Chlamydophila antibodies were detect in 72,1%(106/147) of samples of serum submitted to IFI. In just 9,4% (10/106) of the positive serums in IFI, had complement fixation antibodies, detected by CFT. The CFT, although specific, presented low sensibility when to use to research of anti-Chlamydiaceae antibodies in domestic cats. In cats from catteries, animais between one and six year, and female were more predispose to a presence of antibodies anti-Chlamydophila by IFI. However, these results were not observed in animais PCR positive. Thus, was observed a relationship between the presence of chlamydial DNA and antibodies anti-Chlamydiaceae in Brazilian domestic cats, added with informations of clinical records, like with upper respiratory tract disease, ocular discharge and conjunctivitis.
Abreu, Daniel Paiva Barros de. "Caracteriza??o fenot?pica, genot?pica e perfil de sensibilidade a antif?ngicos de isolados cl?nicos de c?es e gatos pertencentes ao Complexo Sporothrix schenckii oriundos do estado do Rio de Janeiro." Universidade Federal Rural do Rio de Janeiro, 2017. https://tede.ufrrj.br/jspui/handle/jspui/2031.
Full textMade available in DSpace on 2017-09-13T12:31:48Z (GMT). No. of bitstreams: 1 2017 - Daniel Paiva Barros de Abreu.pdf: 1307092 bytes, checksum: b384d4db2cb316d3f640b111bc8efba4 (MD5) Previous issue date: 2017-02-20
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq
Dimorphic fungi belonging to Sporothrix schenckii complex are responsible for sporotrichosis, important fungal infection with worldwide distribution. The anthropozoonotic characteristic is of high relevance in the state of Rio de Janeiro, where an increasing in the number of cases in human patients was observed in the last decades, highlighting the role of domestic cat as a transmitter agent. The description of new species compounding de Sporothrix genus, based on phenotypic and genotypic evaluations, showed the involvement of other members of this group in the epidemic status installed in Rio de Janeiro. The verification of strains resistant to itraconazole, a widely used antifungal in human and animal medicine for the treatment of this mycosis, is an important factor that possibly results in relapse and therapeutic failure of this disease. The present study aimed to identify, by phenotypic and molecular approaches, 168 isolates obtained from the routine of Veterinary Clinical Microbiology Laboratory ? UFRRJ, and the determination of minimal inhibitory concentration (MIC) for amphotericin B (AMB), ketoconazole (KTC), itraconazole (ITC), terbinafine (TRB) and voriconazole (VRC). Based on morphophysiological characteristics it was possible to identify 159 (94.64%) isolates as S. brasiliensis and 9 (5.36%) as S. luriei. However, applying PCR-RFLP of calmodulin 168 (100%) samples were identified as S. brasilensis. The susceptibility test, based on M38-A2 document (CLSI), showed that TRB was the most effective antifungal tested, followed by ITC, KTC, AMB, and VRC, respectively. No ITC resistant isolates were detected in the present study. These results demonstrate that the identification reached only by phenotypic evaluation is not recommended for the characterization of Sporothrix schenckii complex components. It also proves the predominance of S. brasiliensis in other regions of RJ state. The better efficacy of TRB added to the absence of isolates resistant to ITC support the necessity of pharmacodynamics and pharmacokinetics studies for the optimization of the therapeutic protocols. More information about isolates from dogs and cats correlated with the species from the S. schenckii complex, as well as in vitro antifungal efficacy evaluation provide knowledge about therapeutic alternatives. In this way, the present study also provides relevant information about the endemic status in Rio de Janeiro and important data for the treatment of human and animal sporotrichosis.
Fungos dim?rficos pertencentes ao complexo Sporothrix schenckii s?o respons?veis pela esporotricose, importante infec??o f?ngica que apresenta distribui??o mundial. Sua conhecida caracter?stica antropozoon?tica apresenta grande relev?ncia no estado do Rio de Janeiro, onde se verifica aumento significativo no n?mero de pacientes humanos e animais acometidos pela doen?a nas ?ltimas d?cadas, destacando-se em tais casos o papel do felino como agente transmissor. A descri??o de novas esp?cies pertencentes ao g?nero Sporothrix, baseada em caracter?sticas fenot?picas e genot?picas, demonstrou o envolvimento de outros componentes deste g?nero na epidemia instalada no estado. A verifica??o de isolados resistentes a itraconazol, antif?ngico amplamente utilizado na medicina humana e veterin?ria para o tratamento da doen?a, ? fato preocupante e tem poss?vel associa??o a recidivas e falhas terap?uticas. O presente estudo objetiva a identifica??o fenot?pica e genot?pica de 168 exemplares oriundos de pacientes felinos e caninos, obtidos na rotina do Diagn?stico Microbiol?gico Veterin?rio - UFRRJ, com determina??o da Concentra??o Inibit?ria M?nima (CIM) frente ? anfotericina B (AMB), cetoconazol (KTC), itraconazol (ITC), terbinafina (TRB) e voriconazol (VRC). A partir de caracter?sticas morfofisiol?gicas foi poss?vel identificar 159 (94,64%) isolados como S. brasiliensis e 9 (5,36%) como S. luriei. Contudo, metodologias moleculares identificaram 168 (100%) S. brasiliensis, a partir de PCR-RFLP em gene respons?vel pela s?ntese de calmodulina. O teste de sensibilidade, realizado a partir do documento M38-A2 (CLSI) determinou maior efic?cia in vitro para TRB, seguido por ITC, KTC, AMB e VRC, respectivamente. Cepas resistentes a ITC n?o foram detectadas no presente estudo. Tais resultados demonstram que a identifica??o alcan?ada exclusivamente por m?todos fenot?picos n?o ? recomendada para caracteriza??o de componentes do complexo Sporothrix schenckii. Comprova-se ainda a predomin?ncia de S. brasiliensis em outras regi?es do estado do RJ. A maior efic?cia de TRB, somada a aus?ncia de exemplares resistentes a ITC, refor?a a necessidade de estudos farmacodin?micos e farmacocin?ticos para otimiza??o dos protocolos terap?uticos atualmente utilizados. Obten??o de maiores informa??es acerca dos isolados provenientes de amostras provenientes de c?es e gatos correlacionados a esp?cies dentro do complexo S. schenckii, bem como a avalia??o da efic?cia in vitro de antif?ngicos proporcionam conhecimento sobre alternativas terap?uticas. Tais informa??es auxiliam no entendimento do quadro instalado no estado do Rio de Janeiro e fornece dados de grande utilidade para o tratamento humano e veterin?rio
Dawson, Ruby Emily. "Investigation of the GATOR1 complex genes in focal cortical dysplasia and focal epilepsy." Thesis, 2019. http://hdl.handle.net/2440/121340.
Full textThesis (Ph.D.) -- University of Adelaide, School of Biological Sciences, 2019
Santos, Bárbara Costa Matias Machado dos. "Complexo gengivite-estomatite-faringite dos felinos." Master's thesis, 2016. http://hdl.handle.net/10348/5977.
Full textO Complexo Gengivite-Estomatite-Faringite dos Felinos é uma doença frequente nestes animais e caracteriza-se por uma intensa inflamação da cavidade oral e da gengiva. Afeta, principalmente, gatos adultos com cerca de 8 anos de idade, não havendo predisposição sexual. A etiologia não é claramente conhecida, mas suspeita-se que determinadas bactérias, alguns vírus, a alimentação, o ambiente e o maneio (stresse), ou uma conjugação destes fatores com fatores genéticos, originem esta doença. Crê-se que a causa mais provável seja o calicivírus felino. Os sinais clínicos mais frequentemente visualizados são inapetência, disfagia, anorexia, ptialismo, halitose e perda de peso. Para a obtenção do diagnóstico definitivo realiza-se a técnica de Reação em Cadeia da Polimerase, testando a presença de calicivírus, e a Eletroforese de Proteínas para evidenciação de uma gamopatia policlonal. Não existe nenhum protocolo terapêutico totalmente eficaz para esta doença, podendo ser usada uma abordagem médica, cirúrgica, ou uma combinação das duas. No entanto, a extração dentária múltipla ou radical constitui o tratamento de eleição. Esta dissertação tem como objetivo ressaltar aspetos atuais do Complexo Gengivite Estomatite Faringite dos Felinos, desde os principais sinais clínicos, os vários agentes etiológicos envolvidos, os meios de diagnóstico mais relevantes e as diversas formas de tratamento. Nomeadamente, é pretendido mostrar a viabilidade da abordagem com homeopatia no tratamento desta condição. Para além disso, pretendemos alertar os Médicos Veterinários e os proprietários para esta doença, tão frequente na medicina felina. Foram abordados três casos clínicos recolhidos no Hospital Veterinário da Universidade de Trás-os-Montes e Alto Douro em Vila Real. Apenas se obteve o diagnóstico definitivo num dos casos, tendo-se obtido um diagnóstico presuntivo nos restantes, devido à impossibilidade financeira dos proprietários para realizar mais exames. Em relação ao tratamento, é corroborada a ideia de que a extração dentária parcial ou total é a tratamento de eleição para esta doença, tendo sido usada nos três casos. No caso da Clarinha, apenas a homeopatia se revelou eficaz, técnica que ainda não é muito usada, mas que constitui mais uma ferramenta no tratamento desta doença. Estes casos retratam bem a característica recidivante desta doença e o desafio clínico que a mesma representa. O Complexo-Gengivite-Estomatite-Faringite dos Felinos é uma condição frustrante para os Médicos Veterinários e para os proprietários, uma vez que tanto o diagnóstico como o tratamento constituem um enorme desafio clínico e continuará a ser um dos maiores problemas em medicina felina enquanto a patogenia não estiver totalmente esclarecida. Em particular, o papel do calicivírus, do VIF e da disfunção do sistema imunitário e as suas implicações no tratamento precisam de ser melhor esclarecidos.
Feline Chronic Gingivitis Stomatitis (FCGS) is a common disease within the cats and it is characterized by intense oral cavity and gingival inflammation. The FCGS affects, mainly, adult cats around 8 years old and there is no sexual predisposition. The etiology is not clearly known, but it is suspected that certain bacteria, some viruses, food, the environment and management (stress), or a combination of these factors with genetic factors may cause this disease. It is believed that the most likely cause is the feline calicivirus. The most frequently displayed clinical signs are loss of appetite, dysphagia, anorexia, drooling, halitosis and weight loss. In order to obtain a definitive diagnosis it is performed the technique of Polymerase Chain Reaction that tests the presence of calicivirus and Protein Electrophoresis for disclosure of a polyclonal gammopathy. There is no completely effective therapy for this disease, and it can be used surgical, medical approach or a combination of both. However, the multiple or radical tooth extraction is the most used treatment. This dissertation is aimed to highlight aspects of the current Feline Chronic Gingivitis Stomatitis, from the main clinical signs, the various etiological agents involved, the most relevant diagnostic procedures until the various forms of treatment. Namely, it is intended to show the feasibility of the homeopathic approach in the treatment of this condition. Furthermore, we intend to alert veterinarians and owners to this disease, so frequent in feline medicine. It was approached three clinical cases in the Veterinary Hospital of the University of Trás-os-Montes and Alto Douro (VH-UTAD), in Vila Real. The definitive diagnosis was obtained in just one of the clinical cases and it was obtained a presumptive diagnosis in the remaining cases, due to the financial impossibility of the owners to conduct more tests. Concerning the treatment, it is supported that the partial or total dental extraction is the treatment of choice for this disease and it was used in the three clinical cases. In the case of Clarinha, only homeopathy has proved effective though it is a technique that is not yet widely used, but it is another useful tool in the treatment of this disease. These clinical cases demonstrate well the recurrent feature of this disease and the clinical challenge it represents. Feline Chronic Gingivitis Stomatitis is a frustrating condition for veterinarians and owners, since both diagnosis and treatment are a huge clinical challenge and as long as the pathogenesis is not fully understood, it will continue to be a major problem in feline medicine. In particular, the calicivirus and FIV role and the dysfunction of the immune system and its implications in the treatment need to be better understood.
Books on the topic "GATOR1 complex"
Pinto, Analía Verónica. Orozquianas. Editorial de la Universidad Nacional de La Plata (EDULP), 2017. http://dx.doi.org/10.35537/10915/59418.
Full textBook chapters on the topic "GATOR1 complex"
Ivanova, Ilina, and Kuang Shen. "Structures and Functions of the Human GATOR1 Complex." In Subcellular Biochemistry, 269–94. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-58843-3_12.
Full textLeal, Janaina de Fatima Rodrigues, and Fabiane Schneider. "Parceria da gestão pública e do terceiro setor nas políticas públicas de proteção animal." In Administração Contemporânea Vol 4, 19–31. 4th ed. Editora ZH4, 2021. http://dx.doi.org/10.51360/zh4.20218-8-p19-31.
Full textQueiroz, Bruna Barros de, Laís Macêdo Maciel, Gabriel Lúcio Guimarães dos Santos, Caio Victor Barros Gonçalves da Silva, Maria Júlia Brito Couto, and Beatriz Santana Rocha. "Os avanços no tratamento da doença falciforme através da terapia gênica com CRISPR/CAS9." In Avanços em Genética Humana um panorama do 1° simpósio da LAGH, 26–28. Instituto Internacional Despertando Vocações, 2024. http://dx.doi.org/10.31692/978-65-88970-44-7.26-28.
Full textConference papers on the topic "GATOR1 complex"
Sabnis, Amit J., David V. Allegakoen, and Trever G. Bivona. "Abstract 3656: The mTOR-activating GATOR2 complex is essential inPAX3-FOXO1-positive rhabdomyosarcoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3656.
Full textSabnis, Amit J., David V. Allegakoen, and Trever G. Bivona. "Abstract 3656: The mTOR-activating GATOR2 complex is essential inPAX3-FOXO1-positive rhabdomyosarcoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3656.
Full textYoung, Sarah, Michael McClure, and Ursula Emery McClure. "GATOR House: A Typology of Resilience." In 108th Annual Meeting Proceedings. ACSA Press, 2020. http://dx.doi.org/10.35483/acsa.am.108.43.
Full textKarla Alves da Silva, Jéssica, Rebeca Santana Malheiros, and Mary'Anne Rodrigues de Souza. "ESPOROTRICOSE CONJUNTIVAL EM UM FELINO DOMÉSTICO." In Congresso Online Acadêmico de Medicina Veterinária. Congresse.me, 2022. http://dx.doi.org/10.54265/folq8411.
Full textMedrano, L., J. R. Spinelli, and A. R. Bertuccelli. "Sustainability and the megacities: the Gato Park Housing Complex in São Paulo, Brazil." In SUSTAINABLE DEVELOPMENT 2009. Southampton, UK: WIT Press, 2009. http://dx.doi.org/10.2495/sdp090071.
Full textWatanabe, Paola Tieko Chiozzi, Gabriel de Amorim Marques, Izabella Machado Casado, Gabrieli Junqueira Gonçalves, Danielli Aparecida Lavelli, and Leonardo Martins Leal. "Fratura completa de tíbia em canino filhote tratado com tala: relato de caso." In II Congresso Internacional Interdisciplinar da Uningá. Editora Uningá, 2023. http://dx.doi.org/10.46311/ed.un.20221018198.
Full textMarinho, Bruna Sthephany dos Santos. "COMPARAÇÃO CLÍNICA DE AMOSTRAS MICÓTICAS DE GATOS DOMÉSTICOS (FELIS CATUS): ESPOROTRICOSE E CRIPITOCOCOSE." In I Congresso Brasileiro On-line Multiprofissional de Análises Clínicas e Laboratoriais. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/conalab/7839.
Full textLino de Araújo, Cláudia, and Adriana Torrecilhas Jorge. "NEUROFIBROSSARCOMA EM ESCLERA E REGIÃO PERILIMBICA EM UM GATO." In Congresso Online Acadêmico de Medicina Veterinária. Congresse.me, 2022. http://dx.doi.org/10.54265/rvgd2224.
Full textLi, Guifang, and Bahaa E. A. Saleh. "Perturbation analysis of photorefractive phase conjugation." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.tux3.
Full textFoques Falleiro, Manuela, Carolina Schell Franceschina, Marina Ritter Schüler, Anna Eduarda Oliveira Pires Gonçalves, André Mello da Costa Ellwanger, and Roxana Pinto Nishimura. "Esporotricose felina e humana na região metropolitana de Porto Alegre, Rio Grande do Sul." In Congresso Online Acadêmico de Medicina Veterinária. Congresse.me, 2022. http://dx.doi.org/10.54265/uqqz4582.
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