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Journal articles on the topic 'Gastric biomechanics'

Author: Grafiati
Published: 5 April 2025

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1

Kuhar, Sharun, Jung-Hee Seo, Pankaj J. Pasricha, and Rajat Mittal. "Su1655 STOMACHSIM: AN IN-SILICO SIMULATOR OF GASTRIC BIOMECHANICS WITH APPLICATION TO PYLOROPLASTY." Gastroenterology 164, no. 6 (May 2023): S—639. http://dx.doi.org/10.1016/s0016-5085(23)02492-7.

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Estremera-Arevalo, Fermin, John Dent, Taher Omari, and Jennifer Myers. "RA06.02: DETECTION OF ALTERED BOLUS TRANSPORT THROUGH THE ESOPHAGUS AND ESOPHAGO-GASTRIC JUNCTION IN PATIENTS WITH HIATUS HERNIA AND DYSPHAGIA." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 30. http://dx.doi.org/10.1093/dote/doy089.ra06.02.

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Abstract Background Dysphagia can occur in patients with a small hiatus hernia (HH). Whether this relates to a pressure-flow variation through the esophagus or esophago-gastric junction (EGJ) is unknown. Methods High-resolution impedance manometry (HRIM) performed off therapy in 210 reflux patients and 25 age-matched healthy volunteers, recorded 10 × 5mL saline and likewise viscous bolus swallows. Esophageal pressure flow analysis (PFA) with AIMplot v8.0 was undertaken for valid bolus swallows. HRIM EGJ-subtype and endoscopic + /- fluoroscopic imaging enabled HH diagnosis (2–5 cm, > 5 cm excluded). Dysphagia was scored for difficulty swallowing 9 food types (Dakkak and Bennett; 0 none to 45 severe). ANOVA assessed differences in biomechanics of controls and HH + /- patients and dysphagia (D + , > 10/45). Results To date, findings for 135 patients (74M 61F, BMI 28, 19–41) with 70 HH + positive were compared with the 65 HH- negative and 25 healthy controls (7M 18F, BMI 27, 19–37)—see Table. In HH + there was increased resistance (intrabolus pressure) to bolus flow through the esophagus, while pressure during bolus clearance was lower. Further, a higher impedance ratio suggests less effective esophageal emptying, in addition to reduced EGJ outflow time. HH impairs transport of viscous and liquid swallows, affecting patients with HH + and troublesome dysphagia the most. Conclusion A small hiatus hernia alters biomechanics of bolus transport and hinders esophageal and esophago-gastric junction outflow, more so in patients with both dysphagia and hiatus hernia. These findings may relate to altered longitudinal muscle function associated with a short, flaccid esophagus when a hiatus hernia is present. Disclosure All authors have declared no conflicts of interest.
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Toniolo, Ilaria, Chiara Giulia Fontanella, Mirto Foletto, and Emanuele Luigi Carniel. "Coupled experimental and computational approach to stomach biomechanics: Towards a validated characterization of gastric tissues mechanical properties." Journal of the Mechanical Behavior of Biomedical Materials 125 (January 2022): 104914. http://dx.doi.org/10.1016/j.jmbbm.2021.104914.

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Toniolo, Ilaria, Carlo Nostran, Edoardo Ferrari, Edoardo Fongaro, Chiara Fontanella, Mirto Foletto, and Emanuele Carniel. "Patient-specific models of human resected stomach after laparoscopic sleeve gastrectomy: experimental and computational results." Russian Journal of Biomechanics 25, no. 3 (September 30, 2021): 205–16. http://dx.doi.org/10.15593/rjbiomech/2021.3.02.

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The conspicuous increase in obesity rate occurring in the last decades in industrialized countries, often accompanied by high morbidity and high mortality rate, have been made obesity a global health concern. Bariatric surgery is the most effective treatment for severe obesity. However, there are still many issues related to surgical procedures not yet been overcome. The importance of experimenting with a new rational approach based on bioengineering methods could strongly improve surgical approach by avoiding drawbacks and complications. The aim of this work is the construction of patient-specific computational models of the resected stomachs after laparoscopic sleeve gastrectomy able to interpret the structural mechanical behavior of human gastric tissues. A coupled experimental-computational approach was performed. Experimental insufflation tests were performed on nine resected stomachs from laparoscopic sleeve gastrectomy. Through a reverse engineering approach, nine specific-patient computational models were developed, aiming at simulating the experimental activities. A double-layered fiber reinforced anisotropic hyperelastic material formulation was chosen. The experimental evidences provided the pressure-volume behavior of the resected stomachs. The comparison between experimental and computational results permitted to identify the set of the constitutive parameters. The stress-strain distribution described the region and the layer mainly solicited. An engineering approach allows us to characterize the mechanical behavior of the human gastric tissues. Reliable computational models will be used in understanding the biomechanics of the human stomach and will provide a clinical tool to help medical staff in optimizing bariatric procedures.
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Niu, Dong, Yanli Zhang, Jinlan Chen, Dachao Li, Chunmeng He, and Hongzhong Liu. "Mechanobiology Platform Realized Using Photomechanical Mxene Nanocomposites: Bilayer Photoactuator Design and In Vitro Mechanical Forces Stimulation." Materials 15, no. 19 (October 3, 2022): 6869. http://dx.doi.org/10.3390/ma15196869.

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Mechanotransduction is the process by which cells convert external forces and physical constraints into biochemical signals that control several aspects of cellular behavior. A number of approaches have been proposed to investigate the mechanisms of mechanotransduction; however, it remains a great challenge to develop a platform for dynamic multivariate mechanical stimulation of single cells and small colonies of cells. In this study, we combined polydimethylsiloxane (PDMS) and PDMS/Mxene nanoplatelets (MNPs) to construct a soft bilayer nanocomposite for extracellular mechanical stimulation. Fast backlash actuation of the bilayer as a result of near-infrared irradiation caused mechanical force stimulation of cells in a controllable manner. The excellent controllability of the light intensity and frequency allowed backlash bending acceleration and frequency to be manipulated. As gastric gland carcinoma cell line MKN-45 was the research subject, mechanical force loading conditions could trigger apoptosis of the cells in a stimulation duration time-dependent manner. Cell apoptotic rates were positively related to the duration time. In the case of 6 min mechanical force loading, apoptotic cell percentage rose to 34.46% from 5.5% of the control. This approach helps apply extracellular mechanical forces, even with predesigned loading cycles, and provides a solution to study cell mechanotransduction in complex force conditions. It is also a promising therapeutic technique for combining physical therapy and biomechanics.
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Aasarød, Kristin M., Masoud Ramezanzadehkoldeh, Maziar Shabestari, Mats P. Mosti, Astrid K. Stunes, Janne E. Reseland, Vidar Beisvag, et al. "Skeletal effects of a gastrin receptor antagonist in H+/K+ATPase beta subunit KO mice." Journal of Endocrinology 230, no. 2 (August 2016): 251–62. http://dx.doi.org/10.1530/joe-16-0017.

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Epidemiological studies suggest an increased fracture risk in patients taking proton pump inhibitors (PPIs) for long term. The underlying mechanism, however, has been disputed. By binding to the gastric proton pump, PPIs inhibit gastric acid secretion. We have previously shown that proton pump (H+/K+ATPase beta subunit) KO mice exhibit reduced bone mineral density (BMD) and inferior bone strength compared with WT mice. Patients using PPIs as well as these KO mice exhibit gastric hypoacidity, and subsequently increased serum concentrations of the hormone gastrin. In this study, we wanted to examine whether inhibition of the gastrin/CCK2 receptor influences bone quality in these mice. KO and WT mice were given either the gastrin/CCK2 receptor antagonist netazepide dissolved in polyethylene glycol (PEG) or only PEG for 1year. We found significantly lower bone mineral content and BMD, as well as inferior bone microarchitecture in KO mice compared with WT. Biomechanical properties by three-point bending test also proved inferior in KO mice. KO mice receiving netazepide exhibited significantly higher cortical thickness, cortical area fraction, trabecular thickness and trabecular BMD by micro-CT compared with the control group. Three-point bending test also showed higher Young’s modulus of elasticity in the netazepide KO group compared with control mice. In conclusion, we observed that the gastrin receptor antagonist netazepide slightly improved bone quality in this mouse model, suggesting that hypergastrinemia may contribute to deteriorated bone quality during acid inhibition.
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Hudson, P., S. Federer, M. Dunne, C. Pring, and N. Smith. "DOES WEIGHT LOSS THROUGH BARIATRIC SURGERY REDUCE BIOMECHANICAL RISK FACTORS OF OSTEOARTHRITIS?" Orthopaedic Proceedings 106-B, SUPP_18 (November 14, 2024): 64. http://dx.doi.org/10.1302/1358-992x.2024.18.064.

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IntroductionWeight is a modifiable risk factor for osteoarthritis (OA) progression. Despite the emphasis on weight loss, data quantifying the changes seen in joint biomechanics are limited. Bariatric surgery patients experience rapid weight loss. This provides a suitable population to study changes in joint forces and function as weight changes.Method10 female patients undergoing gastric bypass or sleeve gastrectomy completed 3D walking gait analysis at a self-selected pace, pre- and 6 months post-surgery. Lower limb and torso kinematic data for 10 walking trials were collected using a Vicon motion capture system and kinetics using a Kistler force plate. An inverse kinematic model in Visual 3D allowed for no translation of the hip joint centre. 6 degrees of freedom were allowed at other joints. Data were analysed using JASP with a paired samples t-test.ResultOn average participants lost 28.8±7.60kg. No significant changes were observed in standing knee and hip joint angles. Walking velocity increased from 1.10±0.11 ms-1 to 1.23±0.17 ms-1 (t(9)=-3.060, p = 0.014) with no change in step time but a mean increase in stride length of 0.12m (SE: 0.026m; t(9)=-4.476, p = 0.002). A significant decrease of 21.5±4.2% in peak vertical ground reaction forces was observed (t(9)=12.863, p <0.001). Stride width significantly decreased by 0.04m (SE: 0.010m; t(9)=4.316, p = 0.002) along with a decrease in lateral impulse of 21.2Ns (SE: 6.977Ns; t(7), p = 0.019), but no significant difference in knee joint angles were observed. Double limb support time also significantly reduced by 0.02s (SE: 0.006s; t(9) = 3.639, p=0.005)ConclusionThe reduction in stance width and lateral impulse suggests a more sagittal compass-gait walk is being achieved. This would reduce valgus moments on the knee reducing loading in the medial compartment. The reduction in peak ground reaction force would reduce knee contact forces and again potentially slow OA progression.
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Díaz-Barreda, María Dolores, Ignacio Sánchez-Marín, Ana Boned-Murillo, Itziar Pérez-Navarro, Juana Martínez, Elena Pardina-Claver, Diana Pérez, Francisco Javier Ascaso, and Juan Ibáñez. "Modification of Corneal Biomechanics and Intraocular Pressure Following Non-Penetrating Deep Sclerectomy." Journal of Clinical Medicine 11, no. 5 (February 24, 2022): 1216. http://dx.doi.org/10.3390/jcm11051216.

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Changes in the cornea can influence outcomes in patients with primary open-angle glaucoma (POAG). We aimed to evaluate the relevance of changes in corneal biomechanics and intraocular pressure (IOP) in patients undergoing non-penetrating deep sclerectomy (NPDS) with the Esnoper V2000 implant® (AJL Ophthalmic S.A., Gasteiz, Spain). We included 42 eyes of 42 patients with POAG scheduled for NPDS with the Esnoper V2000 implant. Biomechanical properties were measured by Ocular Response Analyzer® G3 (ORA; Reichert Inc., Depew, NY, USA). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) were measured the day before surgery and on day 1, 7, and 30 and 2 and 3 months after surgery. CH initially increased, fell below the presurgical value at 30 days after the surgery, and increased again at 2 and 3 months. CRF, IOPcc, and IOPg decreased on the first day after surgery, then followed a trend of increasing but stayed below pre-surgery levels. All values reached statistical significance. While observed changes in corneal biomechanics after NPDS and Esnoper V2000 implant were significant, more studies are needed if we are to understand their influence on corneal biomechanics and their clinical relevance in POAG.
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Toniolo, Ilaria, Chiara Giulia Fontanella, Mirto Foletto, and Emanuele Luigi Carniel. "Biomechanical Investigation of the Stomach Following Different Bariatric Surgery Approaches." Bioengineering 7, no. 4 (December 9, 2020): 159. http://dx.doi.org/10.3390/bioengineering7040159.

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Background: The stomach is a hollow organ of the gastrointestinal tract, on which bariatric surgery (BS) is performed for the treatment of obesity. Even though BS is the most effective treatment for severe obesity, drawbacks and complications are still present because the intervention design is largely based on the surgeon’s expertise and intraoperative decisions. Bioengineering methods can be exploited to develop computational tools for more rational presurgical design and planning of the intervention. Methods: A computational mechanical model of the stomach was developed, considering the actual complexity of the biological structure, as the nonhomogeneous and multilayered configuration of the gastric wall. Mechanical behavior was characterized by means of an anisotropic visco-hyperelastic constitutive formulation of fiber-reinforced conformation, nonlinear elastic response, and time-dependent behavior, which assume the typical features of gastric wall mechanics. Model applications allowed for an analysis of the influence of BS techniques on stomach mechanical functionality through different computational analyses. Results: Computational results showed that laparoscopic sleeve gastrectomy and endoscopic sleeve gastroplasty drastically alter stomach capacity and stiffness, while laparoscopic adjustable gastric banding modestly affects stomach stiffness and capacity. Moreover, the mean elongation strain values, which are correlated to the mechanical stimulation of gastric receptors, were elevated in laparoscopic adjustable gastric banding compared to other procedures. Conclusions: The investigation of stomach mechanical response through computational models provides information on different topics such as stomach capacity and stiffness and the mechanical stimulation of gastric receptors, which interact with the brain to control satiety. These data can provide reliable support to surgeons in the presurgical decision-making process.
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Kerna, Nicholas A., N. D. Victor Carsrud, Xuan Zhao, Hilary M. Holets, Sudeep Chawla, John V. Flores, Dabeluchi C. Ngwu, Kevin D. Pruitt, Maria Khan, and Rashad Roberson. "The Pathophysiology of Scoliosis Across the Spectrum of Human Physiological Systems." European Journal of Medical and Health Research 2, no. 2 (March 1, 2024): 69–81. http://dx.doi.org/10.59324/ejmhr.2024.2(2).07.

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Scoliosis is a medical condition characterized by an abnormal lateral curvature of the spine. It can lead to various health issues, affecting mobility, respiratory function, and overall quality of life. There are several types of scoliosis, including idiopathic, congenital, neuromuscular, degenerative, and functional. The severity of scoliosis is measured by the degree of spinal curvature, typically expressed in degrees through a system known as the Cobb angle. Early detection and intervention are fundamental in managing scoliosis, as more severe forms may necessitate bracing or surgical intervention. Healthcare professionals must understand the different types of scoliosis and their unique characteristics to tailor appropriate treatment plans.Scoliosis can significantly impact various physiological systems, including the circulatory, digestive, endocrine, integumentary, lymphatic, muscular, nervous, and respiratory systems. In the circulatory system, scoliosis can cause hemodynamic changes, impaired venous return, cardiac strain, and pulmonary complications. In the digestive system, scoliosis can lead to gastric displacement, impaired intra-abdominal pressure, gastroesophageal reflux, and nutritional implications. The endocrine system can be affected by scoliosis, leading to neuroendocrine dysregulation, growth hormone abnormalities, cortisol dysregulation, and impact on thyroid function. Scoliosis can also affect the integumentary system, leading to pressure ulcers, altered skin sensation, and hygiene challenges. In the lymphatic system, scoliosis can cause lymphatic obstruction, impaired immune response, altered inflammatory responses, fibrosis, and secondary lymphedema. Scoliosis can affect the muscular system, leading to muscle imbalance, myofascial pain, respiratory muscle weakness, and mobility issues. The nervous system can also be impacted by scoliosis, leading to neural compression, central nervous system impact, neurological dysfunction, and coordination challenges. In the respiratory system, scoliosis can cause thoracic deformities, reduced lung compliance, ventilation-perfusion mismatch, respiratory muscle weakness, increased work of breathing (WOB), and an increased risk of respiratory infections.Recognizing and addressing the interplay between scoliosis and these physiological systems is integral for healthcare professionals to provide comprehensive care to individuals with scoliosis.Current research on scoliosis has made progress in diagnostic tools and techniques, including the use of imaging methods like MRI and X-ray, wearable sensors, and 3D reconstruction techniques for better evaluation of spinal motion and function, along with treatment strategies like Schroth exercises and braces, and management measures for respiratory and circulatory problems. However, there are limitations to current studies, such as the heterogeneity of scoliosis, compartmentalized approaches, limited longitudinal studies, reliance on retrospective data, and the need for standardized measures and diagnostic criteria. Future research prospects include advancements in genetic research, biomechanics, artificial intelligence and machine learning, longitudinal studies, non-invasive treatments, and multidisciplinary collaborations among researchers, clinicians, and technologists.
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Li, Feifei, Jiannan Liu, Xiaoyun Liu, Yaobin Wu, Lei Qian, Wenhua Huang, and Yanbing Li. "Comparison of the Biomechanical Properties between Healthy and Whole Human and Porcine Stomachs." Bioengineering 11, no. 3 (February 28, 2024): 233. http://dx.doi.org/10.3390/bioengineering11030233.

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Gastric cancer poses a societal and economic burden, prompting an exploration into the development of materials suitable for gastric reconstruction. However, there is a dearth of studies on the mechanical properties of porcine and human stomachs. Therefore, this study was conducted to elucidate their mechanical properties, focusing on interspecies correlations. Stress relaxation and tensile tests assessed the hyperelastic and viscoelastic characteristics of porcine and human stomachs. The thickness, stress–strain curve, elastic modulus, and stress relaxation were assessed. Porcine stomachs were significantly thicker than human stomachs. The stiffness contrast between porcine and human stomachs was evident. Porcine stomachs demonstrated varying elastic modulus values, with the highest in the longitudinal mucosa layer of the corpus and the lowest in the longitudinal intact layer of the fundus. In human stomachs, the elastic modulus of the longitudinal muscular layer of the antrum was the highest, whereas that of the circumferential muscularis layer of the corpus was the lowest. The degree of stress relaxation was higher in human stomachs than in porcine stomachs. This study comprehensively elucidated the differences between porcine and human stomachs attributable to variations across different regions and tissue layers, providing essential biomechanical support for subsequent studies in this field.
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Harrison, Simon M., Paul W. Cleary, and Matthew D. Sinnott. "Investigating mixing and emptying for aqueous liquid content from the stomach using a coupled biomechanical-SPH model." Food & Function 9, no. 6 (2018): 3202–19. http://dx.doi.org/10.1039/c7fo01226h.

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Yan, Jun. "Immune and metabolic pathways of microbial population structure remodeling in biopharmaceuticals for intestinal diseases." Molecular & Cellular Biomechanics 22, no. 3 (February 13, 2025): 934. https://doi.org/10.62617/mcb934.

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Gut microorganisms have become a hot spot of scientific research at home and abroad in recent years, in which the study of correlation between microbial community structure and intestinal diseases can provide theoretical basis for biopharmaceuticals for intestinal diseases. In this paper, we constructed in vitro simulated gastric and small intestinal digestion models, as well as large intestinal microbial fermentation models, to study the relative molecular weight and spatial structure changes of β-glucan in simulated gastric and small intestinal regions, and investigated the degradation of β-glucan in simulated large intestinal regions as well as its effects on intestinal microorganisms. In addition to the biochemical and metabolic aspects, integrating biomechanical principles into this research can enhance our understanding of how gut microbes interact with the host’s physiological environment. For instance, the biomechanical properties of the gut—such as motility, peristalsis, and the mechanical forces exerted on microbial populations—can influence the distribution and activity of gut microorganisms. Understanding these biomechanical factors may reveal how they affect the degradation of β-glucan and the overall microbial community structure. Secondly, fecal microorganisms from different batches of mice and different individuals of human volunteers were collected as inoculum for fermentation of β-glucan, to analyze the main microorganisms that stably responded to β-glucan in different batches of fermentation experiments as well as in gut microorganisms from different individuals and to further investigate the metabolic changes, metabolic pathways as well as the biomarkers of β-glucan in the simulated large intestine. L. murinus Mic06, L. murinus Mic07, L. murinus Mic08, and L. murinus Mic094 were validated to be able to utilize β-glucan and produce a small amount of reducing sugars in all four species of Lactobacillus intestinalis in mice, and there was no significant difference in the ability to utilize them; All nine species of human enterobacteriophages were able to utilize β-glucan and produce reducing sugars, with B. xylanisolvens Bac02 and B. koreensis Bac08 having a significantly greater ability to utilize β-glucan. This study contributes to a deeper understanding of gut disease-associated flora and provides strong support for the use of the gut microbiome for multidisease classification. Additionally, considering biomechanical aspects may lead to novel insights into the interactions between gut microbes and host physiology, enhancing the development of targeted biopharmaceuticals.
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Gregersen, H., O. H. Gilja, T. Hausken, A. Heimdal, C. Gao, K. Matre, S. Ødegaard, and A. Berstad. "Mechanical properties in the human gastric antrum using B-mode ultrasonography and antral distension." American Journal of Physiology-Gastrointestinal and Liver Physiology 283, no. 2 (August 1, 2002): G368—G375. http://dx.doi.org/10.1152/ajpgi.00144.2001.

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The aims of this study were to investigate gastric antral geometry and stress-strain properties by using transabdominal ultrasound scanning during volume-controlled distensions in the human gastric antrum. Seven healthy volunteers underwent stepwise inflation of a bag located in the antrum with volumes up to 60 ml. The stretch ratio and Cauchy stress and strain were calculated from measurements of pressure, diameter, and wall thickness. A second distension series was conducted in three volunteers during administration of the anticholinergic drug butylscopolamine. Analysis of stretch ratios demonstrated positive strain in the circumferential direction, negative strain in the radial direction, and no strain in the longitudinal direction. The stress-strain relation was exponential and did not differ without or with the administration of butylscopolamine. The wall stress was decomposed into its active and passive components. The well-known length-tension diagram from in vitro studies of smooth muscle strips was reproduced. The maximum active tension appeared at a volume of 50 ml, corresponding to a stretch ratio of 1.5. We conclude that the method provides measures of antral biomechanical wall properties and can be used to reproduce the muscle length-tension diagram in humans.
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Japjec, Mladen, Katarina Horvat Pavlov, Andreja Petrovic, Mario Staresinic, Bozidar Sebecic, Matko Buljan, Hrvoje Vranes, et al. "Stable Gastric Pentadecapeptide BPC 157 as a Therapy for the Disable Myotendinous Junctions in Rats." Biomedicines 9, no. 11 (October 27, 2021): 1547. http://dx.doi.org/10.3390/biomedicines9111547.

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(1) Aim: The stable gastric pentadecapeptide BPC 157 is known to heal transected muscle, tendon, and ligament. Thereby, in this study, we investigated the effect of BPC 157 on the dissection of the quadriceps tendon from the quadriceps muscle in rats. (2) Materials and Methods: Myotendinous junction defect, which cannot heal spontaneously in rats, as evidenced with consistent macro/microscopic, biomechanical, functional assessments, eNOS, and COX-2 mRNA levels and oxidative stress and NO-levels in the myotendinous junctions. BPC 157 (10 µg/kg, 10 ng/kg) regimen was given (i) intraperitoneally, first application immediately after surgery, last 24 h before sacrifice; (ii) per-orally, in drinking water (0.16 µg/mL, 0.16 ng/mL, 12 mL/rat/day), till the sacrifice at 7, 14, 28 and 42 postoperative days. (3) Results: These BPC 157 regimens document prominent therapy effects (macro/microscopic, biomechanical, functional much like eNOS and COX-2 mRNA levels and counteracted oxidative stress and NO-levels in the myotendinous junctions), while controls have a poor presentation. Especially, in rats with the disabled myotendinous junction, along with full functional recovery, BPC 157 counteracts muscle atrophy that is regularly progressive and brings muscle presentation close to normal. Accordingly, unlike the perilous course in controls, those rats, when receiving BPC 157 therapy, exhibit a smaller defect, and finally defects completely disappear. Microscopically, there are no more inflammatory infiltrate, well-oriented recovered tissue of musculotendon junction appears in BPC 157 treated rats at the 28 days and 42 days. (4) Conclusions: BPC 157 restores myotendinous junction in accordance with the healing of the transected muscle, tendon, and ligament.
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Varghese, Renjit A., Gleeson Rebello, Hitesh Shah, and Benjamin Joseph. "Biomechanical Basis for Treatment of Pediatric Foot Deformities Part II: Pathomechanics of Common Foot Deformities." Journal of the Pediatric Orthopaedic Society of North America 4, no. 2 (May 1, 2022): 1–18. http://dx.doi.org/10.55275/jposna-2022-0038.

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The biomechanical basis for causation and treatment of pes planus, convex pes valgus (vertical talus), pes cavus, paralytic deformities and foot deformities in cerebral palsy are presented. In each instance, the altered alignment of the hindfoot and forefoot, the configuration of the medial longitudinal arch and the instability of the talo-navicular joint differ. The patterns of muscle imbalance across the axes of movement in paralytic deformities and the concept of treatment aimed at muscle rebalancing across these axes are graphically illustrated. The common deformities of the foot encountered in cerebral palsy are described, in particular, the different deformity patterns resulting from spasticity of the gastrocnemius. The importance of preserving the function of the soleus and avoiding over-lengthening of the gastroc-soleus is emphasized.
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Metcalfe, David, Alison L. Harte, Mina Olga Aletrari, Nasser M. Al Daghri, Dara Al Disi, Gyanendra Tripathi, and Philip G. McTernan. "Does endotoxaemia contribute to osteoarthritis in obese patients?" Clinical Science 123, no. 11 (August 1, 2012): 627–34. http://dx.doi.org/10.1042/cs20120073.

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OA (osteoarthritis) is a degenerative condition associated with obesity. A number of metabolic explanations have been proposed to explain the association between obesity and OA in non-weight-bearing joints; however, none of these hypotheses have been demonstrated empirically. In the present Hypothesis article, we recognize that obesity is associated with compromised gut mucosa, translocation of microbiota and raised serum LPS (lipopolysaccharide). The consequent activation of the innate immune response leads to increased serum titres of inflammatory mediators in obese patients, with both local and systemic markers of inflammation associated with onset and progression of OA. Furthermore, a number of workers have shown that articular cartilage repair is impaired by a range of inflammatory mediators, both in vitro and in vivo. We propose that metabolic endotoxaemia, caused by impaired gastric mucosa and low-grade chronic inflammation, may contribute to the onset and progression of OA in obese patients. This may account for the association between obesity and OA at non-weight-bearing joints which cannot be explained by biomechanical factors.
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Boyd, Roslyn N., Victoria Pliatsios, Roland Starr, Rory Wolfe, and H. Kerr Graham. "Biomechanical transformation of the gastroc-soleus muscle with botulinum toxin A in children with cerebral palsy." Developmental Medicine & Child Neurology 42, no. 1 (February 13, 2007): 32–41. http://dx.doi.org/10.1111/j.1469-8749.2000.tb00022.x.

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Boyd, Roslyn N., Victoria Pliatsios, Roland Starr, Rory Wolfe, and H. Kerr Graham. "Biomechanical transformation of the gastroc–soleus muscle with botulinum toxin A in children with cerebral palsy." Developmental Medicine & Child Neurology 42, no. 01 (September 8, 2000): 32. http://dx.doi.org/10.1017/s0012162200000074.

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Zaitseva, Nina, Peter Trusov, Dmitry Kiryanov, Marat Kamaltdinov, Yulia Ivashova, Darya Lir, and Liubov Sitchikhina. "Full-scale experiment to identify biomechanical parameters of the motor and evacuation functions of the stomach used in a mathematical model of food flow." Russian journal of biomechanics. 28, no. 2 (June 28, 2024): 52–61. http://dx.doi.org/10.15593/rjbiomech/2024.2.05.

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The normal functioning of the stomach, duodenum and other parts of the digestive tract is important for the quality of food digestion. The advantage of mathematical models for studying digestive processes is the ability to predict the characteristics of food flow in the tract depending on various conditions (food properties, individual characteristics of the tract structure, the presence of functional disorders, etc.). However, to obtain ade-quate modeling results, it is necessary to determine the values of the model parameters with the required accuracy Identification of parameters of mathematical models is carried out, as a rule, using experimental data. The purpose of this work was to identify the bio-mechanical parameters of the motor and evacuation functions of the stomach using a full-scale experiment for the subsequent use of the obtained values in a mathematical model. The article describes the procedure for conducting experimental studies to obtain indi-vidual parameters using ultrasound and biochemical blood tests. 10 experimental series of ultrasound studies were conducted after eating breakfast, which differed significantly in composition and caloric content, including both balanced diets (proteins, fats, carbo-hydrates) and those with a predominant content of fats, proteins or carbohydrates. The results provide data on gastric half-emptying time, the parameters of peristaltic waves in the antrum (amplitude, period, speed), the opening period and the diameter of the pyloric sphincter. Correlation coefficients characterizing the relationship between the composi-tion of food taken and the parameters of the motor-evacuation function of the stomach are presented. The data obtained are supposed to be used in the future to construct the geometry of the individual shape of the stomach with time-varying parameters of shape and motility, and to conduct computational experiments with different food compositions. In subsequent publications, a detailed analysis of the relationships between the results of biochemical blood tests and the parameters of stomach motility and the composition of food taken is planned.
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Matek, Danijel, Irena Matek, Eva Staresinic, Mladen Japjec, Ivan Bojanic, Alenka Boban Blagaic, Lidija Beketic Oreskovic, et al. "Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats." Pharmaceutics 17, no. 1 (January 16, 2025): 119. https://doi.org/10.3390/pharmaceutics17010119.

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Background: This is a novel rat study using native peptide therapy, focused on reversing quadriceps muscle-to-bone detachment to reattachment and stable gastric pentadecapeptide BPC 157 per-oral therapy for shared muscle healing and function restoration. Methods: Pharmacotherapy recovering various muscle, tendon, ligament, and bone lesions, and severed junctions (i.e., myotendinous junction), per-oral in particular (BPC 157/kg/day 10 µg, 10 ng), provides muscle-to-bone reattachment after quadriceps muscle detachment, both complete (rectus muscle) and partial (vastus muscles). Results: Immediately post-injury, and at 1, 2, 3, 5, 7, 14, 21, 28, 60, and 90 days post-injury, quadriceps muscle-to-bone detachment showed definitive healing failure (impaired walking and permanent knee flexure). Contrarily, macro/microscopic, ultrasonic, magnetic resonance, biomechanical, and functional assessments revealed that BPC 157 therapy recovering effects for all time points were consistent. All parameters of the walking pattern fully improved, and soon after detachment and therapy application, muscle approached the bone, leaving a minimal gap (on ultrasonic assessment), and leg contracture was annihilated. The healing process occurs immediately after detachment from both sides: the muscle and the bone. The reattachment fibers from the ends of the muscle could be traced into the new bone formed at the surface (note, at day 3 post-detachment, increased mesenchymal cells occurred with periosteum reactivation). Consequently, at 3 months, the form was stable, and the balance between the muscle and bone was the following: well-organized bone, newly formed as more cortical bone providing a narrower bone marrow space, and the muscle and mature fibers were oriented parallel to the bone axis and were in close contact with bone. Conclusions: Therefore, to achieve quadriceps muscle-to-bone reattachment, the BPC 157 therapy reversing course acts from the beginning, resolving an otherwise insurmountable deleterious course.
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Pirogov, R. V., and E. N. Nenashkina. "Study of the possibility of using osteopathic correction for the treatment of patients with non-erosive gastroesophageal refl ux disease." Russian Osteopathic Journal, no. 3 (September 21, 2023): 46–61. http://dx.doi.org/10.32885/2220-0975-2023-3-46-61.

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Introduction. Gastroesophageal refl ux disease (GERD) is a chronic relapsing disease characterized by regularly repeated refl ux of gastric and, in some cases, duodenal contents into the esophagus. The urgency of the GERD problem is due to the widespread prevalence of this disease, a signifi cant decrease in the life quality and working capacity of patients, and it leads to signifi cant material losses and increases the risk of complications with long-term use of proton pump inhibitors. There is evidence of the effectiveness of osteopathic correction as a non-drug method as part of the complex treatment of non-erosive GERD. However, taking into considertion the potential risk of complications (osteoporosis and fractures, vitamin B12 and iron defi ciency, dementia, hypomagnesemia, impaired renal function, infectious complications, neoplasms, cardiovascular complications) caused by the use of the drugs′ treatment of GERD, it is in demand to search for evidence of the effectiveness of osteopathic correction as monotherapy for non-erosive GERD. The aim of the study was to investigate the possibility of using osteopathic correction as a monotherapy for the treatment of patients with non-erosive GERD. Materials and methods. The study involved 26 patients with non-erosive form of GERD. The age of patients was from 22 to 50 years old. Using the method of randomization envelopes, the two groups were formed (control and main). There were 13 patients (4 females and 9 males) in each group. All the study participants were prescribed a correction of the diet and regime of work and rest. Participants in the control group received basic drug therapy according to the Guidelines of the Russian Gastroenterological Association for the diagnosis and treatment of GERD. The dosage and duration were selected individually depending on the clinical manifestations and their duration. Participants of the main group received a course of osteopathic correction (2 sessions with an interval of 12–14 days). All participants underwent an esophagogastroduodenoscopy (EGD) examination at the start of the study. Before and after the treatment in both groups, the severity of GERD symptoms was assessed using the GerdQ questionnaire, as well as osteopathic status was estimated. In addition, we studied the relationship between the structure of dominant somatic dysfunctions (SD) and some indicators of the state of the esophagus and stomach, measured as part of an EGD examination: the cardia of the esophagus and stomach (closes, closes incompletely), transcardial migration of the stomach folds during calm breathing (yes, no), Hiss angle (acute, smoothed), the arch of the stomach during calm breathing (shifts, shifts to a limited extent), the shape of the arch of the stomach (normal, fl attened), the contents of the stomach (usual, with an admixture of bile). Results. The use of an osteopathic correction course for patients with a non-erosive form of GERD is accompanied by a statistically signifi cant (p<0,05) decrease in the severity of symptoms of the disease, assessed by the GerdQ questionnaire. The achieved indicators (the severity of symptoms of the disease, assessed using the GerdQ questionnaire) do not statistically signifi cantly differ from those achieved using standard drug therapy. The course of osteopathic correction is accompanied by a statistically signifi cant (p<0,05) decrease in the severity of biomechanical disorders of the thoracic region. A signifi cant correlation was established between the presence of dominant SD in the thoracic region and the presence of some features of the esophagus and stomach state (incomplete closure of the cardia of the esophagus and stomach, transcardial migration of the stomach folds during quiet breathing, a fl attened Hiss angle, a limited displacement of the gastric fornix during quiet breathing, a fl attened shape of the gastric fornix). Conclusion. The obtained results allow to consider the possibility of using osteopathic correction as a monotherapy for patients with non-erosive GERD. However, it is recommended to continue research in this direction on a larger sample size and using instrumental methods of examination in dynamics.
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Kuhar, Sharun, Jung-Hee Seo, Pankaj Pasricha, and Rajat Mittal. "StomachSim: An in-silico simulator of gastric biomechanics with application to pyloroplasty." Physiology 38, S1 (May 2023). http://dx.doi.org/10.1152/physiol.2023.38.s1.5729950.

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Aim: We have developed StomachSim, an in-silico simulator that is designed to simulate the biomechanics and fluid mechanics of a wide range of gastric conditions as well as gastric surgical procedures. Here we demonstrate its use in quantifying the effects of motility disorders and pyloroplasty on the hydrolysis and emptying of a liquid meal inside the stomach. Methods: A physiologically realistic model of the stomach, including the antral motility, is synthesized based on in-vivo imaging, and the mixing and gastric emptying are simulated using computational fluid dynamics (CFD). The enzymatic biochemistry for protein hydrolysis is also implemented by incorporating the secretion of a proteolytic enzyme from the proximal stomach walls and the subsequent enzymatic reaction with the protein dissolved in the liquid meal. Using this model, we measured the effect of stomach motility and the diameter of the pyloric orifice on the retropulsive and pyloric jets, the rate of hydrolysis in different regions, and the emptying of gastric contents. Results: This study presents a proof-of-concept for the application of StomachSim in gastric disorders and surgeries. The emptying rate of our model for the healthy case agreed with the in-vivo measurements of similar caloric density liquid meals. A stomach with a 50% lower motility amplitude had a 35% lower net emptying rate and a 41% lower emptying rate of the hydrolyzed protein. Furthermore, the emptying rate showed a non-linear variation with respect to the motility of the stomach. For a simulated pyloroplasty procedure where the pyloric orifice diameter is doubled and the orifice stays open permanently, the emptying rate of the lower motility case doubled over its original value. Conclusion: StomachSim offers a novel and potentially effective modality for examining the effect of gastric conditions and gastric surgical procedures on gastric function. Our simulations show that gastroparesis and pyloroplasty not only affect the emptying rate but also alter the mixing of contents thereby changing the rate of hydrolysis. The model helped quantify the changes in the flow of contents in the antro-duodenal region for varying degrees of gastroparesis and pyloroplasty. The authors acknowledge support from NSF award CBET 2019405 and NIH award 1R21GM139073-01. This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
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Toniolo, Ilaria, Alice Berardo, Mirto Foletto, Claudio Fiorillo, Giuseppe Quero, Silvana Perretta, and Emanuele Luigi Carniel. "Patient-specific stomach biomechanics before and after laparoscopic sleeve gastrectomy." Surgical Endoscopy, April 22, 2022. http://dx.doi.org/10.1007/s00464-022-09233-7.

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Abstract Background Obesity has become a global epidemic. Bariatric surgery is considered the most effective therapeutic weapon in terms of weight loss and improvement of quality of life and comorbidities. Laparoscopic sleeve gastrectomy (LSG) is one of the most performed procedures worldwide, although patients carry a nonnegligible risk of developing post-operative GERD and BE. Objectives The aim of this work is the development of computational patient-specific models to analyze the changes induced by bariatric surgery, i.e., the volumetric gastric reduction, the mechanical response of the stomach during an inflation process, and the related elongation strain (ES) distribution at different intragastric pressures. Methods Patient-specific pre- and post-surgical models were extracted from Magnetic Resonance Imaging (MRI) scans of patients with morbid obesity submitted to LSG. Twenty-three patients were analyzed, resulting in forty-six 3D-geometries and related computational analyses. Results A significant difference between the mechanical behavior of pre- and post-surgical stomach subjected to the same internal gastric pressure was observed, that can be correlated to a change in the global stomach stiffness and a minor gastric wall tension, resulting in unusual activations of mechanoreceptors following food intake and satiety variation after LSG. Conclusions Computational patient-specific models may contribute to improve the current knowledge about anatomical and physiological changes induced by LSG, aiming at reducing post-operative complications and improving quality of life in the long run.
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"P279 Gait biomechanics in an obese population before and after gastric bypass surgery." Osteoarthritis and Cartilage 13 (2005): S140—S141. http://dx.doi.org/10.1016/s1063-4584(05)80624-7.

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Lee, Jae Ho, Sharun Kuhar, Jung Hee Seo, Pankaj J. Pasricha, and Rajat Mittal. "Computational modeling of drug dissolution in human stomach: effects of posture and gastroparesis on drug bioavailability." Physics of Fluids, June 24, 2022. http://dx.doi.org/10.1063/5.0096877.

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The oral route is the most common choice for drug administration because of several advantages such as convenience, low cost, and high patient compliance, and the demand and investment in research and development for oral drugs continue to grow. The rate of dissolution and gastric emptying of the dissolved active pharmaceutical ingredient (API) into the duodenum is modulated by gastric motility, physical properties of the pill, and the contents of the stomach, but current in-vitro procedures for assessing dissolution of oral drugs are limited in their ability to recapitulate this process. This is particularly relevant for disease conditions, such as gastroparesis, that alter the anatomy and/or physiology of the stomach. In-silico models of gastric biomechanics offer the potential for overcoming these limitations of existing methods. In the current study we employ a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach (referred to as "StomachSim"), to investigate and quantify the effect of body posture and stomach motility on drug bioavailability. The simulations show that changes in posture can potentially have a significant (up to 83%) effect on the emptying rate of the API into the duodenum. Similarly, reduction in antral contractility associated with gastroparesis can also be found to significantly reduce the dissolution of the pill as well as emptying of the API into the duodenum. The simulations show that for an equivalent motility index, reduction in gastric emptying due to neuropathic gastroparesis is larger by a factor of about five compared to myopathic gastroparesis.
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Heng, Yang, Xinyu Zheng, Youyuan Xu, Jiaqi Yan, Ying Li, Lining Sun, and Hao Yang. "Microfluidic device featuring micro-constrained channels for multi-parametric assessment of cellular biomechanics and high-precision mechanical phenotyping of gastric cells." Analytica Chimica Acta, March 2024, 342472. http://dx.doi.org/10.1016/j.aca.2024.342472.

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Berardo, Alice, Lino Polese, Emanuele Luigi Carniel, and Ilaria Toniolo. "How does sutures pattern influence stomach motility after endoscopic sleeve gastroplasty? A computational study." Updates in Surgery, July 1, 2024. http://dx.doi.org/10.1007/s13304-024-01917-0.

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AbstractThe relatively recent adoption of Endoscopic Sleeve Gastroplasty (ESG) amongst obese patients has gained approval within the surgical community due to its notable benefits, including significant weight loss, safety, feasibility, repeatability, and potential reversibility. However, despite its promising clinical outcomes and reduced invasiveness, there is still a lack of standardised procedures for performing ESG. Multiple suture patterns and stitching methods have been proposed over time, yet rational tools to quantify and compare their effects on gastric tissues are absent. To address this gap, this study proposed a computational approach. The research involved a case study analyzing three distinct suture patterns (C-shaped, U-shaped and Z-shaped) using a patient-specific computational stomach model generated from magnetic resonance imaging. Simulations mimicked food intake by placing wire features in the intragastric cavity to replicate sutures, followed by applying a linearly increasing internal pressure up to 15 mmHg. The outcomes facilitated comparisons between suture configurations based on pressure–volume behaviours and the distribution of maximum stress on biological tissues, revealing the U-shaped as the more effective in terms of volume reduction, even if with reduced elongation strains and increased tissues stresses, whereas the Z-shaped is responsible of the greatest stomach shortness after ESG. In summary, computational biomechanics methods serve as potent tools in clinical and surgical settings, offering insights into aspects that are challenging to explore in vivo, such as tissue elongation and stress. These methods allow for mechanical comparisons between different configurations, although they might not encompass crucial clinical outcomes.
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Zhu, Lijuan, and Hongjing Wang. "Cholesterol‐regulated cellular stiffness may enhance evasion of NK cell‐mediated cytotoxicity in gastric cancer stem cells." FEBS Open Bio, March 17, 2024. http://dx.doi.org/10.1002/2211-5463.13793.

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Gastric cancer has a high rate of recurrence, and as such, immunotherapy strategies are being investigated as a potential therapeutic strategy. Although the involvement of immune checkpoints in immunotherapy is well studied, biomechanical cues, such as target cell stiffness, have not yet been subject to the same level of investigation. Changes in the cholesterol content of the cell membrane directly influence tumor cell stiffness. Here, we investigated the effect of cholesterol on NK cell‐mediated killing of gastric cancer stem‐like cells. We report that surviving tumor cells with stem‐like properties elevated cholesterol metabolism to evade NK cell cytotoxicity. Inhibition of cholesterol metabolism enhances NK cell‐mediated killing of gastric cancer stem‐like cells, highlighting a potential avenue for improving immunotherapy efficacy. This study suggests a possible effect of cancer cell stiffness on immune evasion and offers insights into enhancing immunotherapeutic strategies against tumors.
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Jung, Grace H., Bita Zahedi, Mary L. Bouxsein, and Elaine W. Yu. "Load-to-strength ratio as an estimate of wrist facture after gastric bypass versus gastric banding." JBMR Plus, December 30, 2024. https://doi.org/10.1093/jbmrpl/ziae175.

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Abstract Bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) and adjustable gastric banding (AGB) lead to long-term deficits in bone density but are also accompanied by decreased weight, which may lower the impact force with falls. The aim of this study was to compare the long-term skeletal impact of RYGB and AGB using a biomechanical evaluation of load-to-strength ratio at the distal radius as a surrogate for wrist fracture risk. We conducted a cross-sectional study evaluating bone microarchitectural parameters and bone turnover in adults who received either RYGB or AGB surgery ≥10 years ago (RYGB: n = 22; AGB: n = 23). Bone strength at the distal radius was estimated by microfinite element analysis from high-resolution peripheral quantitative computed tomography (HR-pQCT). We used a single-spring biomechanical model to estimate impact force, and then calculated load-to-strength ratio as a ratio of impact force to bone strength, with higher load-to-strength ratios representing a higher susceptibility to fracture. In multivariable analyses, the RYGB group had higher bone resorption marker C-telopeptide (CTX) levels, lower volumetric bone density, and worse cortical and trabecular microarchitectural parameters than the AGB group. Furthermore, estimated bone strength at the radius was lower in the RYGB group (3725 ± 139 N vs. 4141 ± 157 N, P=.030) and load-to-strength ratio was higher in RYGB group as compared with AGB (0.84 ± 0.04 vs. 0.72 ± 0.05, P=.035), suggestive of higher propensity for wrist fracture. Taken together, these results indicate the long-term deleterious skeletal effects are more concerning with RYGB than AGB.
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Ornellas, Stefanes Antunes de, Ana Claudia Bireahls, Natalia Helena Meneguin, Tais Harumi de Castro Sasahara, Paola Castro Moraes, Maria Luiza Rodrigues De Souza, and Leonardo Martins Leal. "Evaluation of Biomechanical Traction of Incisional Gastropexy and Scarification Gastropexy Techniques in Dogs." Acta Scientiae Veterinariae 49 (April 8, 2021). http://dx.doi.org/10.22456/1679-9216.110522.

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Background: Gastropexy is used to correct gastric dilation, a disease that usually affects large and giant dogs and leads to death in 23.4 - 43% of patients. This study aimed to evaluate the biomechanical traction of 2 gastropexy techniques, incisional gastropexy and scarified gastropexy, in 10 dog cadavers. Incisional gastropexy comprises a single incision in the abdominal wall and another incision in the stomach wall in the pyloric region followed by simple continuous sutures. The scarification technique creates scarification along the stomach borders of the pexy. Thereby, knowing that both techniques are successful, the biomechanical traction of each technique was compared.Materials, Methods & Results: A total of 10 animals without defined breed weighing from 6.4-43.0 kg were allocated into 2 equal groups (GE [scarified gastropexy] and GI [incisional gastropexy]). Incisional gastropexy was performed with a simple continuous suture pattern in the GI group and scarified gastropexy with an interrupted simple suture pattern was performed in the GE group. Absorbable 2-0 monofilament yarn (polygllecaprone 25) was used for sutures in both groups. Rectangular segments of the gastric antrum were collected from the right abdominal wall and from the bottom of the stomach at the left abdominal wall, which were subjected to a traction test. The scarification technique was easier, faster, and used less surgical sutures than the incisional technique. Both techniques were effective regardless of the site applied, with no significant differences. There was a difference in stretching depending on location.Discussion: The pathogenesis of gastric dilatation volvulus (GDV) is unknown. However, gas accumulation inside the gastric chamber may lead to organ dilation and consequently cause torsion of the cardia region and pyloric antrum, resulting in strangulation of blood vessels and nerves. This torsion could cause stomach ischemia followed by organ necrosis if early emergency care is not provided. In addition, vessel strangulation my lead to a systemic syndrome resulting in shock. The disease presents acute and non-specific clinical signs such as weight loss, vomiting, and abdominal intumescence. Patients with risk factors such as reduced gastric motility, delayed stomach replenishment, lower weight, advanced age, or presence of a foreign body may present with poor prognosis. Once GDV becomes an emergency, surgical correction with the most efficient surgical techniques and procedures is necessary to guarantee patient survival. Based on the results obtained, both the scarified and incisional gastropexy techniques are more efficient than other techniques. In addition, the scarified technique with interrupted simple stitches stood out when compared to the incisional technique with a continuous simple suture pattern as it was faster and used less suture thread. The incisional technique, on the other hand, provides good juxtaposition of the edges of the wounds, avoiding the exposure of muscle tissue, as well as adhesions from other organs. The knowledge of those factors promotes positive effects on the effectiveness of an emergency surgical approach for patients with GDV, since it allows less surgical time, as well as less anesthetic time. Based on the results obtained during the biomechanical traction tests of the study, it was concluded that both scarified gastropexy with interrupted single stitches and incisional gastropexy with a continuous single stitch may be efficient. The scarified technique stood out when compared to the incisional technique as it required less time and used less sutures.
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Jung, Grace H., Bita Zahedi, Katherine Lindeman, Claire C. Rushin, Michael C. Cheney, Mary L. Bouxsein, and Elaine Wei-Yin Yu. "OR13-04 Risk Of Wrist Fracture In Gastric Bypass Compared To Gastric Banding As Estimated By The Load-To-Strength Ratio." Journal of the Endocrine Society 7, Supplement_1 (October 2023). http://dx.doi.org/10.1210/jendso/bvad114.471.

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Abstract Disclosure: G.H. Jung: None. B. Zahedi: None. K. Lindeman: None. C.C. Rushin: None. M.C. Cheney: None. M.L. Bouxsein: None. E.W. Yu: Grant Recipient; Self; Amgen Inc. Background: Bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) and adjustable gastric banding (AGB) lead to long-term deficits in bone density but are also accompanied by decreased weight, which may lower the impact force with falls. Given that risk of fracture is dependent on both bone strength and the external force applied to bone, the clinical implications of these opposing effects are unclear. The aim of this study is to compare the long-term skeletal impact of RYGB and AGB using a biomechanical evaluation of load-to-strength ratio as a surrogate for fracture risk. Methods: We examined a cohort of adults who received RYGB and AGB surgery ≥ 10 years ago (RYGB: n=25; AGB: n=25). We computed the load-to-strength ratio at the distal radius as a ratio of impact force to bone strength, with higher load-to-strength ratios representing a higher susceptibility to fracture. Impact force (F) was calculated for a forward fall via a single-spring biomechanical model. High-resolution peripheral quantitative CT was used to estimate bone strength via microfinite element analysis. Participants also had dual-energy X-ray absorptiometry measurements of areal bone mineral density (aBMD) at the spine, hip, and distal radius, along with laboratory evaluations (parathyroid hormone, PTH; C-telopeptide, CTX; type 1 procollagen, P1NP; 25OH-vitamin D). Differences in bone outcomes between RYGB and AGB groups were compared using generalized linear modeling in R version 4.2.2 and adjusted for age, sex/menopausal status, and race/ethnicity. Results: The RYGB and AGB groups were each comprised of 22 women and 3 men. Compared to AGB, the RYGB group was younger (56 vs 62 years), had more premenopausal women (41% vs 9%), more individuals who identified as Black (36% vs 8%) and longer duration since surgery (13 vs 11 years) (p&lt;0.05 for all). Current BMI (34.5 kg/m^2) was similar between groups, although postsurgical weight loss was higher in RYGB (45 vs. 27 kg, p&lt;0.001). In multivariate analysis, in comparison to AGB, the RYGB group had 98% higher CTX and 34% higher P1NP levels (P&lt;0.01 for both), as well as 20% lower total vBMD at the distal radius, 12% lower total hip, 10% lower femoral neck and 8% lower spinal aBMD (P&lt;0.05 for all). Although impact forces were similar in the 2 groups, RYGB had a 12% lower estimated bone strength (3768 ± 182 vs. 4236 ± 193 N, p=0.01). Load-to-strength ratio was numerically higher in RYGB as compared with AGB (0.78 ± 0.05 vs 0.69± 0.06, p=0.1), suggestive of higher fracture risk, although this did not reach statistical significance. Conclusions: Despite achieving similar postoperative weight as AGB, RYGB patients had lower estimated bone strength at the distal radius, higher bone turnover markers, lower BMD and a trend for higher load-to-strength ratio ≥10 years after surgery. Taken together, these results indicate the long-term deleterious skeletal effects are more concerning with RYGB than AGB. Presentation: Friday, June 16, 2023
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Friis, Sif Julie, Torben Strøm Hansen, Mette Poulsen, Hans Gregersen, Annemarie Brüel, and Jens Vinge Nygaard. "Biomechanical properties of the stomach: A comprehensive comparative analysis of human and porcine gastric tissue." Journal of the Mechanical Behavior of Biomedical Materials, December 2022, 105614. http://dx.doi.org/10.1016/j.jmbbm.2022.105614.

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Pan, Yi, F. A. Mann, Colette Wagner-Mann, and R. A. Winholtz. "Addition of two full-thickness simple interrupted sutures to standard incisional gastropexy increases gastropexy biomechanical strength." Journal of the American Veterinary Medical Association, May 30, 2023, 1–6. http://dx.doi.org/10.2460/javma.23.03.0141.

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Abstract OBJECTIVE To compare the acute strength (failure load and work to failure) of standard incisional gastropexy (SIG) and modified incisional gastropexy (MIG). ANIMALS 37 pig cadavers. PROCEDURES Stomachs and right abdominal walls were harvested from pigs euthanized for reasons unrelated to this study. The tissues were stored in lactated Ringer’s solution overnight in a 5 °C cooler. Matching body wall and stomach tissue pairs were randomized and divided into 2 groups, on which either SIG or MIG was performed the following day. The MIG technique was identical to SIG except 2 additional simple interrupted sutures, 1 cranial and 1 caudal to the continuous suture line, were placed full thickness into the stomach to ensure engagement of the submucosa. After gastropexy, the samples underwent biomechanical testing. Information regarding change in position and load was generated by the MTESTQuattro software. Mode of failure was examined after the procedure was complete. RESULTS The MIG had higher failure load and work to failure compared to SIG. All failures were caused by gastric tissue tearing. CLINICAL RELEVANCE The MIG is biomechanically superior to SIG and may provide more security than SIG during healing. However, clinical study is needed to ascertain if there is a difference in gastropexy failure and complications between these 2 techniques.
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Kao, Fu-Cheng, Shih-Feng Hung, Chang-Chi Yang, Parag Parashar, Chun-Ju Huang, Ming-Kai Hsieh, Jen‐Chung Liao, et al. "Ultrasound-driven triboelectric and piezoelectric nanogenerators in biomedical application." Journal of Physics: Energy, March 6, 2024. http://dx.doi.org/10.1088/2515-7655/ad307c.

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Abstract Microelectronics play a crucial role in medical settings by monitoring physiological signals, treating illnesses, and enhancing human well-being. For implanted and wearable devices, a reliable and continuous energy source is essential. While conventional energy systems rely on batteries and external power connections, their drawbacks, including the need for frequent charging, limited battery lifespan, and the potential for reoperation, restrict their utility. This has spurred the exploration of self-sustaining, long-lasting power solutions. The ultrasound-driven nanogenerator, a promising energy source, harnesses biomechanical energy from activities like muscle movement, heartbeat, respiration, and gastric peristalsis. It converts this energy into electrical signals, enabling the detection of physiological and pathological markers, cardiac pacing, nerve stimulation, tissue repair, and weight management. In this review, we provide an overview of triboelectric (TENG) and piezoelectric (PENG) nanogenerator design with ultrasound and its applications in biomedicine, offering insights for the advancement of self-powered medical devices in the future. These devices hold potential for diverse applications, including wound treatment, nerve stimulation and regeneration, as well as charging batteries in implanted devices.&#xD;
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36

"Functional stretching decreases knee joint loading in male athletes with gastroc--soleus tightness." Journal of Men’s Health, 2021. http://dx.doi.org/10.31083/jomh.2021.057.

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Background and objective: Tightness of the gastroc--soleus muscle complex is one of the limiting factors of the ankle joint's range of motion (ROM) during daily activities. The aim of this study was to investigate the effectiveness of functional and extra-functional stretching of the gastrocnemius--soleus complex on knee joint loading in athletes with limited ankle dorsiflexion. Material and methods: In this cross-sectional study, 30 male athletes with gastrocnemius--soleus shortness were recruited and randomly divided into three equal-size groups of functional stretching, extra-functional stretching, and a control group. The extra-functional stretching group performed stretching exercises three times per day for eight weeks. The functional stretching group was instructed to change their gait pattern via increased heel strike during daily activities. Results: None of the stretching programs reduced the knee flexion angle in heel contact (p > 0.05). The knee flexion angle was significantly increased in the stance phase in the functional group (p ≤ 0.05). Walking speed was increased significantly in the extra-functional group (p ≤ 0.05). The knee adductor moment and external rotation moment decreased significantly in the functional group (p ≤ 0.05). Conclusion: An eight-week functional stretching program in this study led to a reduction of knee loading in the frontal and horizontal planes in comparison to the extra-functional stretching group, demonstrating the effectiveness of functional stretching in improving knee joint biomechanics during walking.
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Li, Shuofeng, Yongshuang Xiao, Yang Xu, Wei Du, Keyu Gao, and Jie Li. "A number of the N-terminal RASSF family: RASSF7." Anti-Cancer Agents in Medicinal Chemistry 22 (September 30, 2022). http://dx.doi.org/10.2174/1871520622666220930094149.

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Abstract: The Ras association domain family 7 (RASSF7, also named HRC1), a potential tumor related gene, which is located on human chromosome 11p15, has been identified as an important member of N-terminal RASSF family. Whereas, the molecular biological mechanisms of RASSF7 in tumorigenesis remain to be further established. We perform a systematic review of the literature and assessment from PUBMED and MEDLINE databases in this article. RASSF7 plays a significant role in mitosis, microtubule growth, apoptosis, proliferation and differentiation. Many researching literature show that RASSF7 could promote the occurrence and advance of human tumors by regulating Aurora B, MKK4, MKK7, JNK, YAP, MEK, ERK, whereas, it might inhibit c-Myc and thus lead to the suppression of tumorigenesis. Upregulation of RASSF7 often occur in various malignancies such as lung cancer, neuroblastoma, thyroid neoplasm, hepatocellular cancer, breast cancer and gastric cancer. The expression stage of RASSF7 is positively correlated with tumor TNM stage. In this review, we primarily elaborate the acknowledged structure, progress in the various biomechanisms and research advance of RASSF7 especially the potential relevant signaling pathways. We hope that RASSF7 as a prospective therapeutic target for human malignancies could play an available role in future anti-cancer treatment.
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Marin, Carlos, Georgios Papantonakis, Kathleen Sels, G. Harry van Lenthe, Guillaume Falgayrac, Roman Vangoitsenhoven, Bart Van der Schueren, et al. "Unraveling the compromised biomechanical performance of type 2 diabetes- and Roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties." Scientific Reports 8, no. 1 (April 12, 2018). http://dx.doi.org/10.1038/s41598-018-24229-x.

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Danif, E., H. Santos-Sousa, L. Roxo, R. Bouça-Machado, F. Resende, A. Costa-Pinho, J. Preto, E. Lima da Costa, B. Sousa-Pinto, and S. Carneiro. "IBC-Oxford University2023_BJSPoster_2Gastric Bypass and Bone Health: A Systematic Review and Meta-analysis." British Journal of Surgery 110, Supplement_9 (December 1, 2023). http://dx.doi.org/10.1093/bjs/znad382.029.

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Abstract Introduction Roux-en-Y gastric bypass (RYGB) is a technique widely used in the management of obesity. Changes in bone analytic parameters and areolar bone mineral density (aBMD) are not yet fully understood in patients that underwent RYGB. The aim of this study is to assess the changes in parameters involved in bone metabolism that occur after RYGB and to understand how these changes contribute to the development of osteoporosis, and occurrence of bone fractures. Methods The electronic search included three databases. Inclusion criteria were prospective or retrospective cohort studies, case-control studies, patients with obesity undergoing RYGB, evaluation of changes in bone metabolism parameters, aBMD, osteoporosis and fracture risk. Bone metabolism analytic parameters and aBMD were extracted and analysed. Data is presented in two sets, one year data set and long-term data (≥1 year) set. Results Fifteen studies were included in the review, 11 were included in the meta-analysis. In the long-term analysis parathyroid hormone (PTH) serum concentration increased and calcium serum concentration decreased. Vitamin D serum concentration increased only in the first-year post-surgery. Carboxy-terminal collagen crosslinks (CTX) increased substantially both in the first-year post-op and in the long-term analysis. There was a global decrease on aBMD in all the studied anatomical regions. No study showed a significant increase in the risk of osteoporosis or bone fracture. Conclusion RYGB is associated with a prolonged increase in bone turnover which in turn results in long term loss of bone mass. Greater reductions in aBMD were seen in areas associated with greater biomechanical stress. Despite the bone changes described the occurrence of pathological fractures in the several studies was minimal, this complication remains rare in patients undergoing RYGB.
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Courbette, O., T. Omari, A. Aspirot, and C. Faure. "DOZ047.17: Characterization of esophageal motility in children with operated esophageal atresia using high-resolution impedance manometry and pressure flow analysis." Diseases of the Esophagus 32, Supplement_1 (June 1, 2019). http://dx.doi.org/10.1093/dote/doz047.17.

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Abstract Background Esophageal dysmotility is common in patients with esophageal atresia (EA). High-resolution impedance manometry (HRIM) and pressure flow analysis (PFA) allow characterization of biomechanical bolus flow and swallow properties. The aim of this study was to characterize esophageal motility and bolus flow propulsion in children who underwent surgical EA repair. Patients and Methods HRIM was used in 14 children with EA (type C, n = 13; type A, n = 1). Study was performed at a median (range) age of 11 years (5–17). The HRIM recordings were analyzed using conventional esophageal pressure topography and PFA (AIMplot software deployed via the open access Swallow Gateway application) and were compared with 13 patient controls (median age 14 years, range 5.75–17; P = NS vs patients) who underwent HRIM considered as normal according to Chicago classification and for whom the manometry results did not lead to treatment changes. Medical charts were reviewed for medical/surgical history and symptoms were assessed by standardized questionnaires. Results Esophageal peristaltic motor patterns were abnormal in all EA patients and were subdivided in two groups: Group A with presence of distal contraction in ≥ 50% of the swallows (n = 6) and Group B with presence of distal contractions in < 50% of the swallows (n = 8). IRP4s was similar in EA and controls. Bolus transport was impaired as shown by the higher impedance ratio (IR) in EA than in controls (0.47 vs 0.22, P < 0.001). In Group A, proximal and distal contractile integrals were lower than in controls (P < 0.001) and distal contractile velocity was shorter in EA (P < 0.01). IR was lower in Group A than in Group B (P < 0.01). In this sample, symptoms of dysphagia and presence of gastric metaplasia or esophagitis were not correlated with any of the measures determined. Conclusions Bolus transport as measured by impedance ratio is severely altered in EA patients but is not predictive of symptoms. The presence of residual distal contractions is associated with a more efficient bolus propulsion. Whether this is associated with a better outcome warrants further studies.
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Dirican, Nigar. "Chiari network: Association with other congenital heart diseases Original Article January 2017 338 Views Aim: The study was performed to assess the prevalence of Chiari's Network (CN) in a pediatric outpatient department population by using transthoracic echocardiography (TTE) and to determine its association with other cardiac anomalies. Material and Method: 2232 children who underwent cardiac examination and TTE at the pediatric cardiology outpatient department of our institution between April 2013 and April 2014 were… Additional Info Recieved 04.05.2016 Accepted 10.06.2016 Published Online 10.06.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4603 Author Hashem E. Khosroshahi, Esra Akyuz Ozkan Identifier J Clin Anal Med. 2017;8(1):27-30 Index Page 27-30 Citations in Google Scholar Google Scholar How to Cite Hasim Husrevsahi, Esra Akyuz Ozkan. Chiari network: Association with other congenital heart diseases. J Clin Anal Med. 2017;8(1):27-30 Running Title Chiari Network in children Download attachments: JCAM-4603.pdf Read more... Zinc: Does it have radioprotective effect on major salivary glands? Experimental Study January 2017 291 Views Aim: To evaluate the radioprotective effect of zinc on the major salivary glands with histopathological examination after high doses of radioiodine (131I). Material and Method: Sixteen Wistar albino rats were divided into two groups, eight animals in each group. Three mCi 131I was administrated to each rat in the 131I group (Group 1). Zinc was started via gastric gavage two… Additional Info Recieved 12.07.2016 Accepted 25.07.2016 Published Online 25.07.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4742 Author Murat Sadic, Hasan Ikbal Atilgan, Nihat Yumusak, Meliha Korkmaz, Gokhan Koca Identifier J Clin Anal Med. 2017;8(1):78-82 Index Page 78-82 Citations in Google Scholar Google Scholar How to Cite Murat Sadic, Hasan Ikbal Atilgan, Nihat Yumusak, Meliha Korkmaz, Gokhan Koca. Zinc: Does it have radioprotective effect on major salivary glands?. J Clin Anal Med. 2017;8(1):78-82 Running Title Zinc for salivary gland radioprotection Download attachments: JCAM-4742.pdf Read more... Comparison of preincisional and postincisional 0.25% levobupivacaine infiltration in thyroid surgery Original Article January 2017 286 Views Aim: The use of local anesthetics for pain management following neck surgery is not a well-studied field. Material and Method: Sixty patients scheduled for thyroid surgery were randomly allocated into two groups. Wound infiltration with 0.25% levobupivacaine was performed before the incision in Group 1 and at the end of surgery in Group 2. Pain scores and side effects were… Additional Info Recieved 16.06.2016 Accepted 25.07.2016 Published Online 25.07.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4707 Author Mursel Ekinci, Birzat Emre Golboyu, Ayse Nur Yeksan, Onur Dulgeroglu, Murat Aksun, Pinar Karaca Baysal Identifier J Clin Anal Med. 2017;8(1):74-77 Index Page 74-77 Citations in Google Scholar Google Scholar How to Cite Mursel Ekinci, Birzat Emre Golboyu, Ayse Nur Yeksan, Onur Dulgeroglu, Murat Aksun, Pinar Karaca Baysal. Comparison of preincisional and postincisional 0.25% levobupivacaine infiltration in thyroid surgery. J Clin Anal Med. 2017;8(1):74-77 Running Title Infiltration anesthesia in thyroid surgery Download attachments: JCAM-4707.pdf Read more... Prevalence of smoking and risk factors among students at a university in Turkey Original Article January 2017 307 Views Aim: The aim of this study was to investigate smoking prevalence and related risk factors among students at the Health School and Physical Education & Sports School of a university in Central Turkey.Material and Methods: A cross-sectional study was conducted on total of 1082 students continuing their education at the school from October and December 2015. A multiple-item questionnaire was… Additional Info Recieved 31.05.2016 Accepted 21.07.2016 Published Online 21.07.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4631 Author Ulken Tunga Babaoglu, Sukran Simsek, Serhat Ozdenk, Gökçe Demir, Sibel Cevizci Identifier J Clin Anal Med. 2017;8(1):68-73 Index Page 68-73 Citations in Google Scholar Google Scholar How to Cite Ulken Tunga Babaoglu, Sukran Simsek, Serhat Ozdenk, Gökçe Demir, Sibel Cevizci. Prevalence of smoking and risk factors among students at a university in Turkey. J Clin Anal Med. 2017;8(1):68-73 Running Title Prevalence of smoking and risk factors Download attachments: JCAM-4631.pdf Read more... Matrix metalloproteinases and oxidative stress in patients with AECOPD Original Article January 2017 296 Views Aim: The aim of this study was to determine the relationship between oxidative status, matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and tissue metallopeptidase inhibitor-1 (TIMP-1) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). Material and Method: The study included a total of 35 patients with acute exacerbated COPD and 35 healthy nonsmoker controls. We assessed the concentrations of… Additional Info Recieved 24.06.2016 Accepted 20.07.2016 Published Online 20.07.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4718 Author Halef Okan Dogan, Huseyin Aydin, Ozlem Demirpence, Fatma Mutlu Kukul Guven, Yusuf Kenan Tekin, Ali Sahin Identifier J Clin Anal Med. 2017;8(1):64-67 Index Page 64-67 Citations in Google Scholar Google Scholar How to Cite Halef Okan Dogan, Huseyin Aydin, Ozlem Demirpence, Fatma Mutlu Kukul Guven, Yusuf Kenan Tekin, Ali Sahin. Matrix metalloproteinases and oxidative stress in patients with AECOPD. J Clin Anal Med. 2017;8(1):64-67 Running Title Oxidative stress and AECOPD Download attachments: JCAM-4718.pdf Read more... The effectiveness of adjuvant hyperbaric oxygen therapy in adults who underwent hypospadias surgery Original Article January 2017 221 Views Aim: To evaluate the role of hyperbaric oxygen therapy (HBO2T) with buccal mucosal tube urethroplasty in adult patients with hypospadias. Material and Methods: Sixteen adult patients with hypospadias were included in our study. Patients with a short urethra and penile curvature were treated in two stages (orthoplasty buccal mucosal tube urethroplasty). Buccal mucosa was taken and prepared for tube urethroplasty… Additional Info Recieved 15.06.2016 Accepted 17.07.2016 Published Online 17.07.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4691 Author Onder Kara, Ercan Malkoc, Furkan Dursun, Mesut Mutluoglu, Zeki Aktas, Ali Memis, Hasan Soydan, Ferhat Ateş Identifier J Clin Anal Med. 2017;8(1):60-63 Index Page 60-63 Citations in Google Scholar Google Scholar How to Cite Onder Kara, Ercan Malkoc, Furkan Dursun, Mesut Mutluoglu, Zeki Aktas, Ali Memis, Hasan Soydan, Ferhat Ateş. The effectiveness of adjuvant hyperbaric oxygen therapy in adults who underwent hypospadias surgery. J Clin Anal Med. 2017;8(1):60-63 Running Title Hypospadias and hyperbaric oxygen therapy Download attachments: JCAM-4691.pdf Read more... Biomechanical evaluation of the effect of intramedullary fibular graft in proximal humeral fractures Original Article January 2017 204 Views Aim: The aim of this study is to investigate the biomechanical effect of intramedullary fibular grafts in two-part proximal humeral fracture models. We also investigated two different positions of an intramedullary fibular graft in terms of fracture stability. Material and Method: A total of 21 two-part humeral neck fracture models were randomly separated into 3 groups. All fracture models were… Additional Info Recieved 04.06.2016 Accepted 07.07.2016 Published Online 07.07.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4684 Author Tugrul Bulut, Ulas Akgun, Bora Uzun, Atilla Citlak, Muhittin Sener Identifier J Clin Anal Med. 2017;8(1):56-59 Index Page 56-59 Citations in Google Scholar Google Scholar How to Cite Tugrul Bulut, Ulas Akgun, Bora Uzun, Atilla Citlak, Muhittin Sener. Biomechanical evaluation of the effect of intramedullary fibular graft in proximal humeral fractures. J Clin Anal Med. 2017;8(1):56-59 Running Title The effect of fibular graft in proximal humeral fracture Download attachments: JCAM-4684.pdf Read more... Factors effecting mortality on patients operated on due to gastric carcinoma Original Article January 2017 250 Views Aim: The purpose of the study is to investigate the results of data obtained from the records of patients who were operated due to gastric carcinoma in our hospital, to determine whether the evaluated variables have an effect on mortality. Material and Method: Demographic information (age, gender, contact information, hospital registration, and citizenship number), types of surgery performed (total/subtotal gastrectomy),… Additional Info Recieved 15.06.2016 Accepted 11.07.2016 Published Online 11.07.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4704 Author Tolga Dinc, Selami Ilgaz Kayilioglu, Mesut Tez, Faruk Coskun Identifier J Clin Anal Med. 2017;8(1):52-55 Index Page 52-55 Citations in Google Scholar Google Scholar How to Cite Tolga Dinc, Selami Ilgaz Kayilioglu, Mesut Tez, Faruk Coskun. Factors effecting mortality on patients operated on due to gastric carcinoma. J Clin Anal Med. 2017;8(1):52-55 Running Title Mortality on patients with gastric carcinoma Download attachments: JCAM-4704.pdf Read more... Academic motivations and academic self-efficacy of nursing students Original Article January 2017 266 Views Aim: Academic motivation and academic self-efficacy play important roles in the learning process. They increase academic achievement and the attainment of educational goals, thus providing opportunities in the training of qualified nurses. This study was conducted to determine nursing students%u2019 academic motivation and academic self-efficacy levels. Material and Method: This is a descriptive study. A total of 346 students who… Additional Info Recieved 27.05.2016 Accepted 22.06.2016 Published Online 22.06.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4654 Author Gamze Sarikoc, Emine Oksuz Identifier J Clin Anal Med. 2017;8(1):47-51 Index Page 47-51 Citations in Google Scholar Google Scholar How to Cite Gamze Sarikoc, Emine Oksuz. Academic motivations and academic self-efficacy of nursing students. J Clin Anal Med. 2017;8(1):47-51 Running Title Motivatıon and self efficacy Download attachments: JCAM-4654.pdf Read more... Treatment and follow up outcomes of patients with peroneal nerve injury: A single center experience Original Article January 2017 213 Views Aim: Trap neuropathy is characterized by compression of the peripheral nerve into fibro osseous channels in trespassing areas of body segments. Peroneal nerve is the most frequently injured nerve in traumatic injuries of the lower extremities. In the present study, we investigated functional results of surgical treatment of patients with peroneal nerve injury who delayed visiting our clinics after the… Additional Info Recieved 06.05.2016 Accepted 15.06.2016 Published Online 15.06.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4610 Author Yasar Dagistan Identifier J Clin Anal Med. 2017;8(1):44-46 Index Page 44-46 Citations in Google Scholar Google Scholar How to Cite Yasar Dagistan. Treatment and follow up outcomes of patients with peroneal nerve injury: A single center experience. J Clin Anal Med. 2017;8(1):44-46 Running Title Treatment of the patients with peroneal nerve injury Download attachments: JCAM-4610.pdf Read more... Dyspepsia, irritable bowel syndrome and hematological parameters in recurrent aphthous stomatitis Original Article January 2017 267 Views Aim: The goal of this study was to investigate the relationship between gastrointestinal complaints (dyspepsia, irritable bowel syndrome) and hematological parameters among recurrent aphthous stomatitis (RAS) patients. Material and Method: Forty-four RAS patients with a diagnosis of recurrent oral ulcers in oral mucosa were included in this study. They answered a questionnaire concerning oral aphthous properties, dyspepsia problems, and irritable… Additional Info Recieved 15.04.2016 Accepted 13.06.2016 Published Online 13.06.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4556 Author Sevilay Kilic, Sibel Cevizci, Hacer Sen, Selda Isik, Fahri Gunes, Emine Binnetoglu, Meliha Merve Hız, Zerrin Ogretmen Identifier J Clin Anal Med. 2017;8(1):40-43 Index Page 40-43 Citations in Google Scholar Google Scholar How to Cite Sevilay Kilic, Sibel Cevizci, Hacer Sen, Selda Isik, Fahri Gunes, Emine Binnetoglu, Meliha Merve Hız, Zerrin Ogretmen. Dyspepsia, irritable bowel syndrome and hematological parameters in recurrent aphthous stomatitis. J Clin Anal Med. 2017;8(1):40-43 Running Title Gastrointestinal complaints Download attachments: JCAM-4556.pdf Read more... Evaluation of the contralateral ear in patients with chronic otitis media Original Article January 2017 234 Views Aim: To evaluate the contralateral ear of patients with chronic otitis media (COM) and compare the pathology of the operated ear with the condition of the opposite ear. Material and Methods: Patients with COM who had undergone tympanoplasty, tympanomastoidectomy, or radical mastoidectomy were analyzed retrospectively. The operated ears were evaluated for preoperative diagnoses, surgery types, the number of surgeries, intraoperative… Additional Info Recieved 17.05.2016 Accepted 12.06.2016 Published Online 12.06.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4615 Author Omer Bayir, Ahmet Uluat, Meltem Tulgar, Mehmet Eser Sancaktar, Ali Ozdek, Guleser Saylam, Emel Çadallı Tatar, Mehmet Hakan Korkmaz Identifier J Clin Anal Med. 2017;8(1):36-39 Index Page 36-39 Citations in Google Scholar Google Scholar How to Cite Omer Bayir, Ahmet Uluat, Meltem Tulgar, Mehmet Eser Sancaktar, Ali Ozdek, Guleser Saylam, Emel Çadallı Tatar, Mehmet Hakan Korkmaz. Evaluation of the contralateral ear in patients with chronic otitis media. J Clin Anal Med. 2017;8(1):36-39 Running Title Contralateral ear Download attachments: JCAM-4615.pdf Read more... Mid-term results of rotating hinged knee prosthesis Original Article January 2017 201 Views Aim: In surgeries on patients with advanced ligament instabilities or severe bone defects rotating hinged knee prostheses are one of a limited number of appropriate options. The objective of our study is to evaluate the mid-term functional results and complications of several surgeries using this form of prosthesis. Material and Method: The rotating hinged knee prosthesis (RHKP) was applied to… Additional Info Recieved 20.05.2016 Accepted 06.06.2016 Published Online 06.06.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4642 Author Abdul Fettah Buyuk, Deniz Kargin, Ismet Yalkin Camurcu, Hanifi Ucpunar, Bekir Eray Kilinc, Mehmet Akif Kaygusuz Identifier J Clin Anal Med. 2017;8(1):31-35 Index Page 31-35 Citations in Google Scholar Google Scholar How to Cite Abdul Fettah Buyuk, Deniz Kargin, Ismet Yalkin Camurcu, Hanifi Ucpunar, Bekir Eray Kilinc, Mehmet Akif Kaygusuz. Mid-term results of rotating hinged knee prosthesis. J Clin Anal Med. 2017;8(1):31-35 Running Title Rotating hinged knee prosthesis Download attachments: JCAM-4642.pdf Read more... Adropin levels in polycystic ovary syndrome patients Original Article January 2017 264 Views Aim: Polycystic ovary syndrome (PCOS) is one of the most commonly observed endocrinopathies in women of reproductive age. Women with PCOS are said to have increased classic risk factors for cardiovascular disease, hypertension, dyslipidemia, diabetes, and obesity, in addition to non-classic risk factors such as an increase in C-reactive protein (CRP), homocysteine, and tumor necrosis factor-%u03B1. Adropin is a protein… Additional Info Recieved 28.03.2016 Accepted 16.05.2016 Published Online 16.05.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4508 Author Hacer Sen, Gokhan Erbag, Emine Binnetoglu, Mustafa Eroglu, Hakan Turkon, Sati Zeynep Tekin, Mehmet Asık Identifier J Clin Anal Med. 2017;8(1):23-26 Index Page 23-26 Citations in Google Scholar Google Scholar How to Cite Hacer Sen, Gokhan Erbag, Emine Binnetoglu, Mustafa Eroglu, Hakan Turkon, Sati Zeynep Tekin, Mehmet Asık. Adropin levels in polycystic ovary syndrome patients. J Clin Anal Med. 2017;8(1):23-26 Running Title Adropin in polycystic ovary syndrome Download attachments: JCAM-4508.pdf Read more... Bone mineral density measurements of adult males in Mersin: Comparison of lumbar spine and femur Original Article January 2017 271 Views Aim: We aimed to compare lumbar and femoral neck bone mineral density (BMD) values of geriatric and non-geriatric adult male populations, to find the correlation and the rates of concordance-discordance between BMD values of these two anatomic regions within both age groups. Material and Method: Two hundred and forty men were recruited and divided into two groups, geriatric (n=126) and… Additional Info Recieved 24.04.2016 Accepted 10.05.2016 Published Online 10.05.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4578 Author Sevin Ayaz, Mehmet Ercument Dogen Identifier J Clin Anal Med. 2017;8(1):19-22 Index Page 19-22 Citations in Google Scholar Google Scholar How to Cite Sevin Ayaz, Mehmet Ercument Dogen. Bone mineral density measurements of adult males in Mersin: Comparison of lumbar spine and femur. J Clin Anal Med. 2017;8(1):19-22 Running Title Comparison of lumbar/femoral BMD in men Download attachments: JCAM-4578.pdf Read more... DTPA and MAG3 scintigraphy in acute renal allograft dysfunction: Comparison of diagnostic values Original Article January 2017 244 Views Aim: To compare scintigraphic renal function parameters according to the radiopharmaceuticals used in acute renal allograft dysfunction and to evaluate their value in early diagnosis. Material and Method: Renal scintigraphy, Doppler ultrasonography, and renal biopsy were conducted on 28 patients (20 males, 8 females; mean age 33 ? 2 years) with the diagnosis of acute renal dysfunction (ARD). Renal scintigraphy… Additional Info Recieved 22.04.2016 Accepted 06.05.2016 Published Online 06.05.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4572 Author Sevin Ayaz, Ayse Aktas, Gokhan Moray Identifier J Clin Anal Med. 2017;8(1):14-18 Index Page 14-18 Citations in Google Scholar Google Scholar How to Cite Sevin Ayaz, Ayse Aktas, Gokhan Moray. DTPA and MAG3 scintigraphy in acute renal allograft dysfunction: Comparison of diagnostic values. J Clin Anal Med. 2017;8(1):14-18 Running Title DTPA/MAG3 scintigraphy in renal transplants Download attachments: JCAM-4572.pdf Read more... Increased pathological worry levels in patients with alopecia areata Original Article January 2017 272 Views Aim: Alopecia Areata (AA) is a type of hair loss that has been considered to have associations with various psychiatric disorders. In this study, we aimed to compare pathological worry levels between patients with AA and healthy controls (HC). Material and Method: Sixty-three patients with AA and 90 HCs were included in the present study after applying inclusion and exclusion… Additional Info Recieved 03.04.2016 Accepted 06.05.2016 Published Online 06.05.2016 Printed 01.01.2017 DOI 10.4328/JCAM.4527 Author Basak Sahin, Esra Akyol Soydas , Sevilay Oguz, Selda Isik, Hulya Ertekin Identifier J Clin Anal Med. 2017;8(1):41548 Index Page 41548 Citations in Google Scholar Google Scholar How to Cite Basak Sahin, Esra Akyol Soydas , Sevilay Oguz, Selda Isik, Hulya Ertekin. Increased pathological worry levels in patients with alopecia areata. J Clin Anal Med. 2017;8(1):41548 Running Title Pathological worry alopecia areata Download attachments: JCAM-4527.pdf Read more... Soluble urokinase plasminogen activator receptor (suPAR) in the diagnosis of pulmonary embolism." Journal of Clinical and Analytical Medicine 8, no. 1 (January 1, 2017). http://dx.doi.org/10.4328/jcam.4557.

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Chavdarov, Anatoliy V. "Special Issue No. – 10, June, 2020 Journal > Special Issue > Special Issue No. – 10, June, 2020 > Page 5 “Quantative Methods in Modern Science” organized by Academic Paper Ltd, Russia MORPHOLOGICAL AND ANATOMICAL FEATURES OF THE GENUS GAGEA SALISB., GROWING IN THE EAST KAZAKHSTAN REGION Authors: Zhamal T. Igissinova,Almash A. Kitapbayeva,Anargul S. Sharipkhanova,Alexander L. Vorobyev,Svetlana F. Kolosova,Zhanat K. Idrisheva, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00041 Abstract: Due to ecological preferences among species of the genus GageaSalisb, many plants are qualified as rare and/or endangered. Therefore, the problem of rational use of natural resources, in particular protection of early spring plant species is very important. However, literary sources analysis only reveals data on the biology of species of this genus. The present research,conducted in the spring of 2017-2019, focuses on anatomical and morphological features of two Altai species: Gagealutea and Gagea minima; these features were studied, clarified and confirmed by drawings and photographs. The anatomical structure of the stem and leaf blade was studied in detail. The obtained research results will prove useful for studies of medicinal raw materials and honey plants. The aforementioned species are similar in morphological features, yet G. minima issmaller in size, and its shoots appear earlier than those of other species Keywords: Flora,gageas,Altai species,vegetative organs., Refference: I. Atlas of areas and resources of medicinal plants of Kazakhstan.Almaty, 2008. II. Baitenov M.S. Flora of Kazakhstan.Almaty: Ġylym, 2001. III. DanilevichV. G. ThegenusGageaSalisb. of WesternTienShan. PhD Thesis, St. Petersburg,1996. IV. EgeubaevaR.A., GemedzhievaN.G. The current state of stocks of medicinal plants in some mountain ecosystems of Kazakhstan.Proceedings of the international scientific conference ‘”Results and prospects for the development of botanical science in Kazakhstan’, 2002. V. Kotukhov Yu.A. New species of the genus Gagea (Liliaceae) from Southern Altai. Bot. Journal.1989;74(11). VI. KotukhovYu.A. ListofvascularplantsofKazakhstanAltai. Botan. Researches ofSiberiaandKazakhstan.2005;11. VII. KotukhovYu. The current state of populations of rare and endangered plants in Eastern Kazakhstan. Almaty: AST, 2009. VIII. Kotukhov Yu.A., DanilovaA.N., AnufrievaO.A. Synopsisoftheonions (AlliumL.) oftheKazakhstanAltai, Sauro-ManrakandtheZaisandepression. BotanicalstudiesofSiberiaandKazakhstan. 2011;17: 3-33. IX. Kotukhov, Yu.A., Baytulin, I.O. Rareandendangered, endemicandrelictelementsofthefloraofKazakhstanAltai. MaterialsoftheIntern. scientific-practical. conf. ‘Sustainablemanagementofprotectedareas’.Almaty: Ridder, 2010. X. Krasnoborov I.M. et al. The determinant of plants of the Republic of Altai. Novosibirsk: SB RAS, 2012. XI. Levichev I.G. On the species status of Gagea Rubicunda. Botanical Journal.1997;6:71-76. XII. Levichev I.G. A new species of the genus Gagea (Liliaceae). Botanical Journal. 2000;7: 186-189. XIII. Levichev I.G., Jangb Chang-gee, Seung Hwan Ohc, Lazkovd G.A.A new species of genus GageaSalisb.(Liliaceae) from Kyrgyz Republic (Western Tian Shan, Chatkal Range, Sary-Chelek Nature Reserve). Journal of Asia-Pacific Biodiversity.2019; 12: 341-343. XIV. Peterson A., Levichev I.G., Peterson J. Systematics of Gagea and Lloydia (Liliaceae) and infrageneric classification of Gagea based on molecular and morphological data. Molecular Phylogenetics and Evolution.2008; 46. XV. Peruzzi L., Peterson A., Tison J.-M., Peterson J. Phylogenetic relationships of GageaSalisb.(Liliaceae) in Italy, inferred from molecular and morphological data matrices. Plant Systematics and Evolution; 2008: 276. XVI. Rib R.D. Honey plants of Kazakhstan. Advertising Digest, 2013. XVII. Scherbakova L.I., Shirshikova N.A. Flora of medicinal plants in the vicinity of Ust-Kamenogorsk. Collection of materials of the scientific-practical conference ‘Unity of Education, Science and Innovation’. Ust-Kamenogorsk: EKSU, 2011. XVIII. syganovA.P. PrimrosesofEastKazakhstan. Ust-Kamenogorsk: EKSU, 2001. XIX. Tsyganov A.P. Flora and vegetation of the South Altai Tarbagatay. Berlin: LAP LAMBERT,2014. XX. Utyasheva, T.R., Berezovikov, N.N., Zinchenko, Yu.K. ProceedingsoftheMarkakolskStateNatureReserve. Ust-Kamenogorsk, 2009. XXI. Xinqi C, Turland NJ. Gagea. Flora of China.2000;24: 117-121. XXII. Zarrei M., Zarre S., Wilkin P., Rix E.M. Systematic revision of the genus GageaSalisb. (Liliaceae) in Iran.BotJourn Linn Soc.2007;154. XXIII. Zarrei M., Wilkin P., Ingroille M.J., Chase M.W. A revised infrageneric classification for GageaSalisb. (Tulipeae; Liliaceae): insights from DNA sequence and morphological data.Phytotaxa.2011:5. View | Download INFLUENCE OF SUCCESSION CROPPING ON ECONOMIC EFFICIENCY OF NO-TILL CROP ROTATIONS Authors: Victor K. Dridiger,Roman S. Stukalov,Rasul G. Gadzhiumarov,Anastasiya A. Voropaeva,Viktoriay A. Kolomytseva, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00042 Abstract: This study was aimed at examining the influence of succession cropping on the economic efficiency of no-till field crop rotations on the black earth in the zone of unstable moistening of the Stavropol krai. A long-term stationary experiment was conducted to examine for the purpose nine field crop rotation patterns different in the number of fields (four to six), set of crops, and their succession in crop rotation. The respective shares of legumes, oilseeds, and cereals in the cropping pattern were 17 to 33, 17 to 40, and 50 to 67 %. It has been established that in case of no-till field crop cultivation the economic efficiency of plant production depends on the set of crops and their succession in rotation. The most economically efficient type of crop rotation is the soya-winter wheat-peas-winter wheat-sunflower-corn six-field rotation with two fields of legumes: in this rotation 1 ha of crop rotation area yields 3 850 grain units per ha at a grain unit prime cost of 5.46 roubles; the plant production output return and profitability were 20,888 roubles per ha and 113 %, respectively. The high production profitabilities provided by the soya-winter wheat-sunflower four-field and the soya-winter-wheat-sunflower-corn-winter wheat five-field crop rotation are 108.7 and 106.2 %, respectively. The inclusion of winter wheat in crop rotation for two years in a row reduces the second winter wheat crop yield by 80 to 100 %, which means a certain reduction in the grain unit harvesting rate to 3.48-3.57 thousands per ha of rotation area and cuts the production profitability down to 84.4-92.3 %. This is why, no-till cropping should not include winter wheat for a second time Keywords: No-till technology,crop rotation,predecessor,yield,return,profitability, Refference: I Badakhova G. Kh. and Knutas A. V., Stavropol Krai: Modern Climate Conditions [Stavropol’skiykray: sovremennyyeklimaticheskiyeusloviya]. Stavropol: SUE Krai Communication Networks, 2007. II Cherkasov G. N. and Akimenko A. S. Scientific Basis of Modernization of Crop Rotations and Formation of Their Systems according to the Specializations of Farms in the Central Chernozem Region [Osnovy moderniz atsiisevooborotoviformirovaniyaikh sistem v sootvetstvii so spetsi-alizatsiyeykhozyaystvTsentral’nogoChernozem’ya]. Zemledelie. 2017; 4: 3-5. III Decree 330 of July 6, 2017 the Ministry of Agriculture of Russia “On Approving Coefficients of Converting to Agricultural Crops to Grain Units [Ob utverzhdeniikoeffitsiyentovperevoda v zernovyyee dinitsysel’s kokhozyaystvennykhkul’tur]. IV Dridiger V. K., About Methods of Research of No-Till Technology [O metodikeissledovaniytekhnologii No-till]//Achievements of Science and Technology of AIC (Dostizheniyanaukiitekhniki APK). 2016; 30 (4): 30-32. V Dridiger V. K. and Gadzhiumarov R. G. Growth, Development, and Productivity of Soya Beans Cultivated On No-Till Technology in the Zone of Unstable Moistening of Stavropol Region [Rost, razvitiyeiproduktivnost’ soiprivozdelyvaniipotekhnologii No-till v zone ne-ustoychivog ouvlazhneniyaStavropol’skogokraya]//Oil Crops RTBVNIIMK (Maslichnyyekul’turyNTBVNIIMK). 2018; 3 (175): 52–57. VI Dridiger V. K., Godunova E. I., Eroshenko F. V., Stukalov R. S., Gadzhiumarov, R. G., Effekt of No-till Technology on erosion resistance, the population of earthworms and humus content in soil (Vliyaniyetekhnologii No-till naprotivoerozionnuyuustoychivost’, populyatsiyudozhdevykhcherveyisoderzhaniyegumusa v pochve)//Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018; 9 (2): 766-770. VII Karabutov A. P., Solovichenko V. D., Nikitin V. V. et al., Reproduction of Soil Fertility, Productivity and Energy Efficiency of Crop Rotations [Vosproizvodstvoplodorodiyapochv, produktivnost’ ienergeticheskayaeffektivnost’ sevooborotov]. Zemledelie. 2019; 2: 3-7. VIII Kulintsev V. V., Dridiger V. K., Godunova E. I., Kovtun V. I., Zhukova M. P., Effekt of No-till Technology on The Available Moisture Content and Soil Density in The Crop Rotation [Vliyaniyetekhnologii No-till nasoderzhaniyedostupnoyvlagiiplotnost’ pochvy v sevoob-orote]// Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2017; 8 (6): 795-99. IX Kulintsev V. V., Godunova E. I., Zhelnakova L. I. et al., Next-Gen Agriculture System for Stavropol Krai: Monograph [SistemazemledeliyanovogopokoleniyaStavropol’skogokraya: Monogtafiya]. Stavropol: AGRUS Publishers, Stavropol State Agrarian University, 2013. X Lessiter Frank, 29 reasons why many growers are harvesting higher no-till yields in their fields than some university scientists find in research plots//No-till Farmer. 2015; 44 (2): 8. XI Rodionova O. A. Reproduction and Exchange-Distributive Relations in Farming Entities [Vosproizvodstvoiobmenno-raspredelitel’nyyeotnosheniya v sel’skokhozyaystvennykhorganizatsiyakh]//Economy, Labour, and Control in Agriculture (Ekonomika, trud, upravleniye v sel’skomkhozyaystve). 2010; 1 (2): 24-27. XII Sandu I. S., Svobodin V. A., Nechaev V. I., Kosolapova M. V., and Fedorenko V. F., Agricultural Production Efficiency: Recommended Practices [Effektivnost’ sel’skokhozyaystvennogoproizvodstva (metodicheskiyerekomendatsii)]. Moscow: Rosinforagrotech, 2013. XIII Sotchenko V. S. Modern Corn Cultivation Technologies [Sovremennayatekhnologiyavozdelyvaniya]. Moscow: Rosagrokhim, 2009. View | Download DEVELOPMENT AND TESTING OF AUTONOMOUS PORTABLE SEISMOMETER DESIGNED FOR USE AT ULTRALOW TEMPERATURES IN ARCTIC ENVIRONMENT Authors: Mikhail A. Abaturov,Yuriy V. Sirotinskiy, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00043 Abstract: This paper is concerned with solving one of the issues of the general problem of designing geophysical equipment for the natural climatic environment of the Arctic. The relevance of the topic has to do with an increased global interest in this region. The paper is aimed at considering the basic principles of developing and the procedure of testing seismic instruments for use at ultralow climatic temperatures. In this paper the indicated issue is considered through the example of a seismic module designed for petroleum and gas exploration by passive seismoacoustic methods. The seismic module is a direct-burial portable unit of around 5 kg in weight, designed to continuously measure and record microseismic triaxial orthogonal (ZNE) noise in a range from 0.1 to 45 Hz during several days in autonomous mode. The functional chart of designing the seismic module was considered, and concrete conclusions were made for choosing the necessary components to meet the ultralow-temperature operational requirements. The conclusions made served for developing appropriate seismic module. In this case, the components and tools used included a SAFT MP 176065 xc low-temperature lithium cell, industrial-spec electronic component parts, a Zhaofeng Geophysical ZF-4.5 Chinese primary electrodynamic seismic sensor, housing seal parts made of frost-resistant silicone materials, and finely dispersed silica gel used as water-retaining sorbent to avoid condensation in the housing. The paper also describes a procedure of low-temperature collation tests at the lab using a New Brunswick Scientific freezing plant. The test results proved the operability of the developed equipment at ultralow temperatures down to -55°C. In addition, tests were conducted at low microseismic noises in the actual Arctic environment. The possibility to detect signals in a range from 1 to 10 Hz at the level close to the NLNM limit (the Peterson model) has been confirmed, which allows monitoring and exploring petroleum and gas deposits by passive methods. As revealed by this study, the suggested approaches are efficient in developing high-precision mobile seismic instruments for use at ultralow climatic temperatures. The solution of the considered instrumentation and methodical issues is of great practical significance as a constituent of the generic problem of Arctic exploration. Keywords: Seismic instrumentation,microseismic monitoring,Peterson model,geological exploration,temperature ratings,cooling test, Refference: I. AD797: Ultralow Distortion, Ultralow Noise Op Amp, Analog Devices, Inc., Data Sheet (Rev. K). Analog Devices, Inc. URL: https://www.analog.com/media/en/technical-documentation/data-sheets/AD797.pdf(Date of access September 2, 2019). II. Agafonov, V. M., Egorov, I. V., and Shabalina, A. S. Operating Principles and Technical Characteristics of a Small-Sized Molecular–Electronic Seismic Sensor with Negative Feedback [Printsipyraboty I tekhnicheskiyekharakteristikimalogabaritnogomolekulyarno-elektronnogoseysmodatchika s otritsatel’noyobratnoysvyaz’yu]. SeysmicheskiyePribory (Seismic Instruments). 2014; 50 (1): 1–8. DOI: 10.3103/S0747923914010022. III. Antonovskaya, G., Konechnaya, Ya.,Kremenetskaya, E., Asming, V., Kvaema, T., Schweitzer, J., Ringdal, F. Enhanced Earthquake Monitoring in the European Arctic. Polar Science. 2015; 1 (9): 158-167. 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Chao Xu, Junbo Wang, Deyong Chen, Jian Chen, Bowen Liu, Wenjie Qi, XichenZheng, Hua Wei, Guoqing Zhang. The Electrochemical Seismometer Based on a Novel Designed.Sensing Electrode for Undersea Exploration. 20th International Conference on Solid-State Sensors, Actuators and Microsystems &Eurosensors XXXIII (TRANSDUCERS &EUROSENSORS XXXIII). IEEE, 2019. DOI: 10.1109/TRANSDUCERS.2019.8808450. VIII. Chebotareva, I. Ya. New algorithms of emission tomography for passive seismic monitoring of a producing hydrocarbon deposit: Part I. Algorithms of processing and numerical simulation [Novyye algoritmyemissionnoyto mografiidlyapassivnogoseysmicheskogomonitoringarazrabatyvayemykhmestorozhdeniyuglevodorodov. Chast’ I: Algoritmyobrabotki I chislennoyemodelirovaniye]. FizikaZemli. 2010; 46(3):187-98. DOI: 10.1134/S106935131003002X IX. Danilov, A. V. and Konechnaya, Ya. V. Analytical comparison of seismic instruments for stationary surveys in the Arctic [Sravnitel’nyyanalizseysmicheskoyapparaturydlyastatsionarnykhnablyudeniy v Arktike]. DSYS. URL: https://dsys.ru/upload/id254_docPDF_FranzJosefLand.pdf(Date of access September 2, 2019). X. Dew point temperature calculator. Maple Tech. International LLC. URL: https://www.calculator.net/dew-point-calculator.html?airtemperature=20&airtemperatureunit=celsius&humidity=0.34&dewpoint=&dewpointunit=celsius&x=51&y=14(Date of access September 2, 2019). XI. Frolov, A. S. Matching of wave fields recorded by different geophysical receivers [Soglasovaniyevolnovykhpoley, poluchennykh s primeneniyemrazlichnoyregistriruyushcheyapparatury]. Abstracts IX International scientific and technical conference competition of young specialists “Geophysics-2013”. Saint-Petersburg: Gubkin University, 2013. 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Passive seismic tomography: A passive concept actively evolving. First Break. 2012; 30 (7): 83-90. XXII. Matveev, I. V. and Matveeva, N. V. Portable seismic recorder “SEISAR-5” with very low energy consumption for autonomous work in harsh climatic conditions [Portativnyyseysmicheskiyregistrator «Seysar-5» s ochen’ nizkimenergopotrebleniyemdlyaavtonomnoyraboty v slozhnykhklimatic heskikhusloviyakh]. Nauka I tekhnologicheskierazrabotki (Science and Technological Developments). 2017; 96 (3): 33-40. [Special Issue “Applied Geophysics: New Developments and Results. Part 1. Seismology and Seismic Exploration]. DOI: 10.21455/std2017.3-3. XXIII. Mishra, R. The Temperature Ratings of Electronic Parts.Electronics Cooling magazine. URL: http://www.electronics-cooling.com/2004/02/the-temperature-ratings-of-electronic-parts(Date of access September 2, 2019). XXIV. Moore, Sue E.; Stabeno, Phyllis J.; Van Pelt, Thomas I. The Synthesis of Arctic Research (SOAR) project. 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View | Download COMPARATIVE ANALYSIS OF RESULTS OF TREATMENT OF PATIENTS WITH FOOT PATHOLOGY WHO UNDERWENT WEIL OPEN OSTEOTOMY BY CLASSICAL METHOD AND WITHOUT STEOSYNTHESIS Authors: Yuriy V. Lartsev,Dmitrii A. Rasputin,Sergey D. Zuev-Ratnikov,Pavel V.Ryzhov,Dmitry S. Kudashev,Anton A. Bogdanov, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00044 Abstract: The article considers the problem of surgical correction of the second metatarsal bone length. The article analyzes the results of treatment of patients with excess length of the second metatarsal bones that underwent osteotomy with and without osteosynthesis. The results of treatment of patients who underwent metatarsal shortening due to classical Weil-osteotomy with and without osteosynthesis were analyzed. The first group consisted of 34 patients. They underwent classical Weil osteotomy. The second group included 44 patients in whomosteotomy of the second metatarsal bone were not by the screw. When studying the results of the treatment in the immediate postoperative period, weeks 6, 12, slightly better results were observed in patients of the first group, while one year after surgical treatment the results in both groups were comparable. One year after surgical treatment, there were 2.9% (1 patient) of unsatisfactory results in the first group and 4.5% (2 patients) in the second group. Considering the comparability of the results of treatment in remote postoperative period, the choice of concrete method remains with the operating surgeon. Keywords: Flat feet,hallux valgus,corrective osteotomy,metatarsal bones, Refference: I. A novel modification of the Stainsby procedure: surgical technique and clinical outcome [Text] / E. Concannon, R. MacNiocaill, R. Flavin [et al.] // Foot Ankle Surg. – 2014. – Dec., Vol. 20(4). – P. 262–267. II. Accurate determination of relative metatarsal protrusion with a small intermetatarsal angle: a novel simplified method [Text] / L. Osher, M.M. Blazer, S. Buck [et al.] // J. Foot Ankle Surg. – 2014. – Sep.-Oct., Vol. 53(5). – P. 548–556. III. Argerakis, N.G. The radiographic effects of the scarf bunionectomy on rearfoot alignment [Text] / N.G. Argerakis, L.Jr. Weil, L.S. Sr. Weil // Foot Ankle Spec. – 2015. – Apr., Vol. 8(2). – P. 89–94. IV. Bauer, T. Percutaneous forefoot surgery [Text] / T. Bauer // Orthop. Traumatol. Surg. Res. – 2014. – Feb., Vol. 100(1 Suppl.). – P. S191–S204. V. Biomechanical Evaluation of Custom Foot Orthoses for Hallux Valgus Deformity [Text] // J. Foot Ankle Surg. – 2015. – Sep.-Oct., Vol.54(5). – P. 852–855. VI. Chopra, S. Characterization of gait in female patients with moderate to severe hallux valgus deformity [Text] / S. Chopra, K. Moerenhout, X. Crevoisier // Clin. Biomech. (Bristol, Avon). – 2015. – Jul., Vol. 30(6). – P. 629–635. VII. Computer assisted planning and custom-made surgical guide for malunited pronation deformity after first metatarsophalangeal joint arthrodesis in rheumatoid arthritis: a case report [Text] / M. Hirao, S. Ikemoto, H. Tsuboi [et al.] // Comput. Aided Surg. – 2014. – Vol. 19(1-3). – P. 13–19. VIII. Correlation between static radiographic measurements and intersegmental angular measurements during gait using a multisegment foot model [Text] / D.Y. Lee, S.G. Seo, E.J. Kim [et al.] // Foot Ankle Int. – 2015. – Jan., Vol.36(1). – P. 1–10. IX. Correlative study between length of first metatarsal and transfer metatarsalgia after osteotomy of first metatarsal [Text]: [Article in Chinese] / F.Q. Zhang, B.Y. Pei, S.T. Wei [et al.] // Zhonghua Yi XueZaZhi. – 2013. – Nov. 19, Vol. 93(43). – P. 3441–3444. X. Dave, M.H. Forefoot Deformity in Rheumatoid Arthritis: A Comparison of Shod and Unshod Populations [Text] / M.H. Dave, L.W. Mason, K. Hariharan // Foot Ankle Spec. – 2015. – Oct., Vol. 8(5). – P. 378–383. XI. Does arthrodesis of the first metatarsophalangeal joint correct the intermetatarsal M1M2 angle? Analysis of a continuous series of 208 arthrodeses fixed with plates [Text] / F. Dalat, F. Cottalorda, M.H. Fessy [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6). – P. 709–714. XII. Dynamic plantar pressure distribution after percutaneous hallux valgus correction using the Reverdin-Isham osteotomy [Text]: [Article in Spanish] / G. Rodríguez-Reyes, E. López-Gavito, A.I. Pérez-Sanpablo [et al.] // Rev. Invest. Clin. – 2014. – Jul., Vol. 66, Suppl. 1. – P. S79-S84. XIII. Efficacy of Bilateral Simultaneous Hallux Valgus Correction Compared to Unilateral [Text] / A.V. Boychenko, L.N. Solomin, S.G. Parfeyev [et al.] // Foot Ankle Int. – 2015. – Nov., Vol. 36(11). – P. 1339–1343. XIV. Endolog technique for correction of hallux valgus: a prospective study of 30 patients with 4-year follow-up [Text] / C. Biz, M. Corradin, I. Petretta [et al.] // J. OrthopSurg Res. – 2015. – Jul. 2, № 10. – P. 102. XV. First metatarsal proximal opening wedge osteotomy for correction of hallux valgus deformity: comparison of straight versus oblique osteotomy [Text] / S.H. Han, E.H. Park, J. Jo [et al.] // Yonsei Med. J. – 2015. – May, Vol. 56(3). – P. 744–752. XVI. Long-term outcome of joint-preserving surgery by combination metatarsal osteotomies for shortening for forefoot deformity in patients with rheumatoid arthritis [Text] / H. Niki, T. Hirano, Y. Akiyama [et al.] // Mod. Rheumatol. – 2015. – Sep., Vol. 25(5). – P. 683–638. XVII. Maceira, E. Transfer metatarsalgia post hallux valgus surgery [Text] / E. Maceira, M. Monteagudo // Foot Ankle Clin. – 2014. – Jun., Vol. 19(2). – P.285–307. XVIII. Nielson, D.L. Absorbable fixation in forefoot surgery: a viable alternative to metallic hardware [Text] / D.L. Nielson, N.J. Young, C.M. Zelen // Clin. Podiatr. Med. Surg. – 2013. – Jul., Vol. 30(3). – P. 283–293 XIX. Patient’s satisfaction after outpatient forefoot surgery: Study of 619 cases [Text] / A. Mouton, V. Le Strat, D. Medevielle [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6 Suppl.). – P. S217–S220. XX. Preference of surgical procedure for the forefoot deformity in the rheumatoid arthritis patients–A prospective, randomized, internal controlled study [Text] / M. Tada, T. Koike, T. Okano [et al.] // Mod. Rheumatol. – 2015. – May., Vol. 25(3). – P.362–366. XXI. Redfern, D. Percutaneous Surgery of the Forefoot [Text] / D. Redfern, J. Vernois, B.P. Legré // Clin. Podiatr. Med. Surg. – 2015. – Jul., Vol. 32(3). – P. 291–332. XXII. Singh, D. Bullous pemphigoid after bilateral forefoot surgery [Text] / D. Singh, A. Swann // Foot Ankle Spec. – 2015. – Feb., Vol. 8(1). – P. 68–72. XXIII. Treatment of moderate hallux valgus by percutaneous, extra-articular reverse-L Chevron (PERC) osteotomy [Text] / J. Lucas y Hernandez, P. Golanó, S. Roshan-Zamir [et al.] // Bone Joint J. – 2016. – Mar., Vol. 98-B(3). – P. 365–373. XXIV. Weil, L.Jr. Scarf osteotomy for correction of hallux abducto valgus deformity [Text] / L.Jr. Weil, M. Bowen // Clin. Podiatr. Med. Surg. – 2014. – Apr., Vol.31(2). – P. 233–246. View | Download QUANTITATIVE ULTRASONOGRAPHY OF THE STOMACH AND SMALL INTESTINE IN HEALTHYDOGS Authors: Roman A. Tcygansky,Irina I. Nekrasova,Angelina N. Shulunova,Alexander I.Sidelnikov, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00045 Abstract: Purpose.To determine the quantitative echogenicity indicators (and their ratio) of the layers of stomach and small intestine wall in healthy dogs. Methods. A prospective 3-year study of 86 healthy dogs (aged 1-7 yrs) of different breeds and of both sexes. Echo homogeneity and echogenicity of the stomach and intestines wall were determined by the method of Silina, T.L., et al. (2010) in absolute values ​​of average brightness levels of ultrasound image pixels using the 8-bit scale with 256 shades of gray. Results. Quantitative echogenicity indicators of the stomach and the small intestine wall in dogs were determined. Based on the numerical values ​​characterizing echogenicity distribution in each layer of a separate structure of the digestive system, the coefficient of gastric echogenicity is determined as 1:2.4:1.1 (mucosa/submucosa/muscle layers, respectively), the coefficient of duodenum and jejunum echogenicity is determined as 1:3.5:2 and that of ileum is 1:1.8:1. Clinical significance. The echogenicity coefficient of the wall of the digestive system allows an objective assessment of the stomach and intestines wall and can serve as the basis for a quantitative assessment of echogenicity changes for various pathologies of the digestive system Keywords: Ultrasound (US),echogenicity,echogenicity coefficient,digestive system,dogs,stomach,intestines, Refference: I. Agut, A. Ultrasound examination of the small intestine in small animals // Veterinary focus. 2009.Vol. 19. No. 1. P. 20-29. II. Bull. 4.RF patent 2398513, IPC51A61B8 / 00 A61B8 / 14 (2006.01) A method for determining the homoechogeneity and the degree of echogenicity of an ultrasound image / T. Silina, S. S. Golubkov. – No. 2008149311/14; declared 12/16/2008; publ. 09/10/2010 III. Choi, M., Seo, M., Jung, J., Lee, K., Yoon, J., Chang, D., Park, RD. Evaluation of canine gastric motility with ultrasonography // J. of Veterinary Medical Science. – 2002. Vol. 64. – № 1. – P. 17-21. IV. Delaney, F., O’Brien, R.T., Waller, K.Ultrasound evaluation of small bowel thickness compared to weight in normal dogs // Veterinary Radiology and Ultrasound. 2003 Vol. 44, № 5. Р 577-580. V. Diana, A., Specchi, S., Toaldo, M.B., Chiocchetti, R., Laghi, A., Cipone, M. Contrast-enhanced ultrasonography of the small bowel in healthy cats // Veterinary Radiology and Ultrasound. – 2011. – Vol. 52, № 5. – Р. 555-559. VI. Garcia, D.A.A., Froes, T.R. Errors in abdominal ultrasonography in dogs and cats // J. of Small Animal Practice. – 2012. Vol. 53. – № 9. – P. 514-519. VII. Garcia, D.A.A., Froes, T.R. Importance of fasting in preparing dogs for abdominal ultrasound examination of specific organs // J. of Small Animal Practice. – 2014. Vol. 55. – № 12. – P. 630-634. VIII. Gaschen, L., Granger, L.A., Oubre, O., Shannon, D., Kearney, M., Gaschen, F. The effects of food intake and its fat composition on intestinal echogenicity in healthy dogs // Veterinary Radiology and Ultrasound. 2016. Vol. 57. № 5. P. 546-550 IX. Gaschen, L., Kircher, P., Stussi, A., Allenspach, K., Gaschen, F., Doherr, M., Grone, A. Comparison of ultrasonographic findings with clinical activity index (CIBDAI) and diagnosis in dogs with chronic enteropathies // Veterinary radiology and ultrasound. – 2008. – Vol. 49. – № 1. – Р. 56-64. X. Gil, E.M.U. Garcia, D.A.A. Froes, T.R. In utero development of the fetal intestine: Sonographic evaluation and correlation with gestational age and fetal maturity in dogs // Theriogenology. 2015. Vol. 84, №5. Р. 681-686. XI. Gladwin, N.E. Penninck, D.G., Webster, C.R.L. Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs // American Journal of Veterinary Research. 2014. Vol. 75, №4. Р. 349-353. XII. Gory, G., Rault, D.N., Gatel, L, Dally, C., Belli, P., Couturier, L., Cauvin, E. Ultrasonographic characteristics of the abdominal esophagus and cardia in dogs // Veterinary Radiology and Ultrasound. 2014. Vol. 55, № 5. P. 552-560. XIII. Günther, C.S. Lautenschläger, I.E., Scholz, V.B. Assessment of the inter- and intraobserver variability for sonographical measurement of intestinal wall thickness in dogs without gastrointestinal diseases | [Inter-und Intraobserver-Variabilitätbei der sonographischenBestimmung der Darmwanddicke von HundenohnegastrointestinaleErkrankungen] // Tierarztliche Praxis Ausgabe K: Kleintiere – Heimtiere. 2014. Vol. 42 №2. Р. 71-78. XIV. Hanazono, K., Fukumoto, S., Hirayama, K., Takashima, K., Yamane, Y., Natsuhori, M., Kadosawa, T., Uchide, T. Predicting Metastatic Potential of gastrointestinal stromal tumors in dog by ultrasonography // J. of Veterinary Medical Science. – 2012. Vol. 74. – № 11. – P. 1477-1482. XV. Heng, H.G., Lim, Ch.K., Miller, M.A., Broman, M.M.Prevalence and significance of an ultrasonographic colonic muscularishyperechoic band paralleling the serosal layer in dogs // Veterinary Radiology and Ultrasound. 2015. Vol. 56 № 6. P. 666-669. XVI. Ivančić, M., Mai, W. Qualitative and quantitative comparison of renal vs. hepatic ultrasonographic intensity in healthy dogs // Veterinary Radiology and Ultrasound. 2008. Vol. 49. № 4. Р. 368-373. XVII. Lamb, C.R., Mantis, P. Ultrasonographic features of intestinal intussusception in 10 dogs // J. of Small Animal Practice. – 2008. Vol. 39. – № 9. – P. 437-441. XVIII. Le Roux, A. B., Granger, L.A., Wakamatsu, N, Kearney, M.T., Gaschen, L.Ex vivo correlation of ultrasonographic small intestinal wall layering with histology in dogs // Veterinary Radiology and Ultrasound.2016. Vol. 57. № 5. P. 534-545. XIX. Nielsen, T. High-frequency ultrasound of Peyer’s patches in the small intestine of young cats / T. Nielsen [et al.] // Journal of Feline Medicine and Surgery. – 2015. – Vol. 18, № 4. – Р. 303-309. XX. PenninckD.G. Gastrointestinal tract. In Nyland T.G., Mattoon J.S. (eds): Small Animal Diagnostic Ultrasound. Philadelphia: WB Saunders. 2002, 2nd ed. Р. 207-230. XXI. PenninckD.G. Gastrointestinal tract. In: PenninckD.G.,d´Anjou M.A. Atlas of Small Animal Ultrasonography. Blackwell Publishing, Iowa. 2008. Р. 281-318. XXII. Penninck, D.G., Nyland, T.G., Kerr, L.Y., Fisher, P.E. Ultrasonographic evaluation of gastrointestinal diseases in small animals // Veterinary Radiology. 1990. Vol. 31. №3. P. 134-141. XXIII. Penninck, D.G.,Webster, C.R.L.,Keating, J.H. The sonographic appearance of intestinal mucosal fibrosis in cats // Veterinary Radiology and Ultrasound. – 2010. – Vol. 51, № 4. – Р. 458-461. XXIV. Pollard, R.E.,Johnson, E.G., Pesavento, P.A., Baker, T.W., Cannon, A.B., Kass, P.H., Marks, S.L. Effects of corn oil administered orally on conspicuity of ultrasonographic small intestinal lesions in dogs with lymphangiectasia // Veterinary Radiology and Ultrasound. 2013. Vol. 54. № 4. P. 390-397. XXV. Rault, D.N., Besso, J.G., Boulouha, L., Begon, D., Ruel, Y. Significance of a common extended mucosal interface observed in transverse small intestine sonograms // Veterinary Radiology and Ultrasound. 2004. Vol. 45. №2. Р. 177-179. XXVI. Sutherland-Smith, J., Penninck, D.G., Keating, J.H., Webster, C.R.L. Ultrasonographic intestinal hyperechoic mucosal striations in dogs are associated with lacteal dilation // Veterinary Radiology and Ultrasound. – 2007. Vol. 48. – № 1. – P. 51-57. View | Download EVALUATION OF ADAPTIVE POTENTIAL IN MEDICAL STUDENTS IN THE CONTEXT OF SEASONAL DYNAMICS Authors: Larisa A. Merdenova,Elena A. Takoeva,Marina I. Nartikoeva,Victoria A. Belyayeva,Fatima S. Datieva,Larisa R. Datieva, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00046 Abstract: The aim of this work was to assess the functional reserves of the body to quantify individual health; adaptation, psychophysiological characteristics of the health quality of medical students in different seasons of the year. When studying the temporal organization of physiological functions, the rhythm parameters of physiological functions were determined, followed by processing the results using the Cosinor Analysis program, which reveals rhythms with an unknown period for unequal observations, evaluates 5 parameters of sinusoidal rhythms (mesor, amplitude, acrophase, period, reliability). The essence of desynchronization is the mismatch of circadian rhythms among themselves or destruction of the rhythms architectonics (instability of acrophases or their disappearance). Desynchronization with respect to the rhythmic structure of the body is of a disregulatory nature, most pronounced in pathological desynchronization. High neurotism, increased anxiety reinforces the tendency to internal desynchronization, which increases with stress. During examination stress, students experience a decrease in the stability of the temporary organization of the biosystem and the tension of adaptive mechanisms develops, which affects attention, mental performance and the quality of adaptation to the educational process. Time is shortened and the amplitude of the “initial minute” decreases, personal and situational anxiety develops, and the level of psychophysiological adaptation decreases. The results of the work are priority because they can be used in assessing quality and level of health. Keywords: Desynchronosis,biorhythms,psycho-emotional stress,mesor,acrophase,amplitude,individual minute, Refference: I. Arendt, J., Middleton, B. Human seasonal and circadian studies in Antarctica (Halley, 75_S) – General and Comparative Endocrinology. 2017: 250-259. (http://dx.doi.org/10.1016/j.ygcen.2017.05.010). II. BalandinYu.P. A brief methodological guide on the use of the agro-industrial complex “Health Sources” / Yu.P. Balandin, V.S. Generalov, V.F. Shishlov. Ryazan, 2007. III. Buslovskaya L.K. Adaptation reactions in students at exam stress/ L.K. Buslovskaya, Yu.P. Ryzhkova. Scientific bulletin of Belgorod State University. Series: Natural Sciences. 2011;17(21):46-52. IV. Chutko L. S. Sindromjemocionalnogovygoranija – Klinicheskie I psihologicheskieaspekty./ L.S Chutko. Moscow: MEDpress-inform, 2013. V. Eroshina K., Paul Wilkinson, Martin Mackey. The role of environmental and social factors in the occurrence of diseases of the respiratory tract in children of primary school age in Moscow. Medicine. 2013:57-71. VI. Fagrell B. “Microcirculation of the Skin”. The physiology and pharmacology of the microcirculation. 2013:423. VII. Gurova O.A. Change in blood microcirculation in students throughout the day. New research. 2013; 2 (35):66-71. VIII. Khetagurova L.G. – Stress/Ed. L.G. Khetagurov. Vladikavkaz: Project-Press Publishing House, 2010. IX. Khetagurova L.G., Urumova L.T. et al. Stress (chronomedical aspects). International Journal of Experimental Education 2010; 12: 30-31. X. Khetagurova L.G., Salbiev K.D., Belyaev S.D., Datieva F.S., Kataeva M.R., Tagaeva I.R. Chronopathology (experimental and clinical aspects/ Ed. L.G. Khetagurov, K.D. Salbiev, S.D.Belyaev, F.S. Datiev, M.R. Kataev, I.R. Tagaev. Moscow: Science, 2004. XI. KlassinaS.Ya. Self-regulatory reactions in the microvasculature of the nail bed of fingers in person with psycho-emotional stress. Bulletin of new medical technologies, 2013; 2 (XX):408-412. XII. Kovtun O.P., Anufrieva E.V., Polushina L.G. Gender-age characteristics of the component composition of the body in overweight and obese schoolchildren. Medical Science and Education of the Urals. 2019; 3:139-145. XIII. Kuchieva M.B., Chaplygina E.V., Vartanova O.T., Aksenova O.A., Evtushenko A.V., Nor-Arevyan K.A., Elizarova E.S., Efremova E.N. A comparative analysis of the constitutional features of various generations of healthy young men and women in the Rostov Region. Modern problems of science and education. 2017; 5:50-59. XIV. Mathias Adamsson1, ThorbjörnLaike, Takeshi Morita – Annual variation in daily light expo-sure and circadian change of melatonin and cortisol consent rations at a northern latitude with large seasonal differences in photoperiod length – Journal of Physiological Anthropology. 2017; 36: 6 – 15. XV. Merdenova L.A., Tagaeva I.R., Takoeva E.A. Features of the study of biological rhythms in children. The results of fundamental and applied research in the field of natural and technical sciences. Materials of the International Scientific and Practical Conference. Belgorod, 2017, pp. 119-123. XVI. Ogarysheva N.V. The dynamics of mental performance as a criterion for adapting to the teaching load. Bulletin of the Samara Scientific Center of the Russian Academy of Sciences. 2014;16:5 (1): S.636-638. XVII. Pekmezovi T. Gene-environment interaction: A genetic-epidemiological approach. Journal of Medical Biochemistry. 2010;29:131-134. XVIII. Rapoport S.I., Chibisov S.M. Chronobiology and chronomedicine: history and prospects/Ed. S.M. Chibisov, S.I. Rapoport ,, M.L. Blagonravova. Chronobiology and Chronomedicine: Peoples’ Friendship University of Russia (RUDN) Press. Moscow, 2018. XIX. Roustit M., Cracowski J.L. “Non-invasive assessment of skin microvascular function in humans: an insight into methods” – Microcirculation 2012; 19 (1): 47-64. XX. Rud V.O., FisunYu.O. – References of the circadian desinchronosis in students. Ukrainian Bulletin of Psychoneurology. 2010; 18(2) (63): 74-77. XXI. Takoeva Z. A., Medoeva N. O., Berezova D. T., Merdenova L. A. et al. Long-term analysis of the results of chronomonitoring of the health of the population of North Ossetia; Vladikavkaz Medical and Biological Bulletin. 2011; 12(12,19): 32-38. XXII. Urumova L.T., Tagaeva I.R., Takoeva E.A., Datieva L.R. – The study of some health indicators of medical students in different periods of the year. Health and education in the XXI century. 2016; 18(4): 94-97. XXIII. Westman J. – Complex diseases. In: Medical genetics for the modern clinician. USA: Lippincott Williams & Wilkins, 2006. XXIV. Yadrischenskaya T.V. Circadian biorhythms of students and their importance in educational activities. Problems of higher education. Pacific State University Press. 2016; 2:176-178. View | Download TRIADIC COMPARATIVE ANALYSIS Authors: Stanislav A.Kudzh,Victor Ya. Tsvetkov, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00047 Abstract: The present study of comparison methods based on the triadic model introduces the following concepts: the relation of comparability and the relation of comparison, and object comparison and attributive comparison. The difference between active and passive qualitative comparison is shown, two triadic models of passive and active comparison and models for comparing two and three objects are described. Triadic comparison models are proposed as an alternative to dyadic comparison models. Comparison allows finding the common and the different; this approach is proposed for the analysis of the nomothetic and ideographic method of obtaining knowledge. The nomothetic method identifies and evaluates the general, while the ideographic method searches for unique in parameters and in combinations of parameters. Triadic comparison is used in systems and methods of argumentation, as well as in the analysis of consistency/inconsistency. Keywords: Comparative analysis,dyad,triad,triadic model,comparability relation,object comparison,attributive comparison,nomothetic method,ideographic method, Refference: I. AltafS., Aslam.M.Paired comparison analysis of the van Baarenmodel using Bayesian approach with noninformativeprior.Pakistan Journal of Statistics and Operation Research 8(2) (2012) 259{270. II. AmooreJ. E., VenstromD Correlations between stereochemical assessments and organoleptic analysis of odorous compounds. Olfaction and Taste (2016) 3{17. III. BarnesJ., KlingerR. Embedding projection for targeted cross-lingual sentiment: model comparisons and a real-world study. Journal of Artificial Intelligence Research 66 (2019) 691{742. doi.org/10.1613/jair.1.11561 IV. Castro-SchiloL., FerrerE.Comparison of nomothetic versus idiographic-oriented methods for making predictions about distal outcomes from time series data. Multivariate Behavioral Research 48(2) (2013) 175{207. V. De BonaG.et al. Classifying inconsistency measures using graphs. Journal of Artificial Intelligence Research 66 (2019) 937{987. VI. FideliR. La comparazione. Milano: Angeli, 1998. VII. GordonT. F., PrakkenH., WaltonD. The Carneades model of argument and burden of proof. Artificial Intelligence 10(15) (2007) 875{896. VIII. GrenzS.J. The social god and the relational self: A Triad theology of the imago Dei. Westminster: John Knox Press, 2001. IX. HermansH.J. M.On the integration of nomothetic and idiographic research methods in the study of personal meaning.Journal of Personality 56(4) (1988) 785{812. X. JamiesonK. G., NowakR. Active ranking using pairwise comparisons.Advances in Neural Information Processing Systems (2011) 2240{2248. XI. JongsmaC.Poythress’s triad logic: a review essay. Pro Rege 42(4) (2014) 6{15. XII. KärkkäinenV.M. Trinity and Religious Pluralism: The Doctrine of the Trinity in Christian Theology of Religions. London: Routledge, 2017. XIII. KudzhS. A., TsvetkovV.Ya. Triadic systems. Russian Technology Magazine 7(6) (2019) 74{882. XIV. NelsonK.E.Some observations from the perspective of the rare event cognitive comparison theory of language acquisition.Children’s Language 6 (1987) 289{331. XV. NiskanenA., WallnerJ., JärvisaloM.Synthesizing argumentation frameworks from examples. Journal of Artificial Intelligence Research 66 (2019) 503{554. XVI. PührerJ.Realizability of three-valued semantics for abstract dialectical frameworks.Artificial Intelligence 278 (2020) 103{198. XVII. SwansonG.Frameworks for comparative research: structural anthropology and the theory of action. In: Vallier, Ivan (Ed.). Comparative methods in sociology: essays on trends and applications.Berkeley: University of California Press, 1971 141{202. XVIII. TsvetkovV.Ya.Worldview model as the result of education.World Applied Sciences Journal 31(2) (2014) 211{215. XIX. TsvetkovV. Ya. Logical analysis and variable scales. Slavic Forum 4(22) (2018) 103{109. XX. Wang S. et al. Transit traffic analysis zone delineating method based on Thiessen polygon. Sustainability 6(4) (2014) 1821{1832. View | Download DEVELOPING TECHNOLOGY OF CREATING WEAR-RESISTANT CERAMIC COATING FOR ICE CYLINDER." JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES spl10, no. 1 (June 28, 2020). http://dx.doi.org/10.26782/jmcms.spl.10/2020.06.00048.

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