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Academic literature on the topic 'Gastric acid – Popular works'

Author: Grafiati
Published: 27 July 2024
Last updated: 29 July 2024

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Journal articles on the topic "Gastric acid – Popular works"

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Kim, Mi-Ryung, Tae-Il Kim, Beom-Rak Choi, Moon Bong Kim, Il Je Cho, Keun-Woo Lee, and Sae Kwang Ku. "Brassica oleracea Prevents HCl/Ethanol-Induced Gastric Damages in Mice." Applied Sciences 11, no. 1 (December 22, 2020): 16. http://dx.doi.org/10.3390/app11010016.

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Brassica oleracea var. capitata L. (cabbage) is a popular vegetable with a wide range of pharmacological activities that help to promote human health. The present study investigated the beneficial effects of B. oleracea var. capitata L. extract (BOE) on HCl/ethanol (H/E)-induced gastric damages in mice. Pre-administration of BOE (25–100 mg/kg) for 7 consecutive days significantly decreased macroscopically visible lesion on the gastric mucosa induced by H/E. In addition, results from hematoxylin and eosin-stained gastric tissue showed that BOE inhibited invaded percentage of lesion and prevented the reduction in mucosal thickness in peri-ulcerative region. BOE significantly alleviated the H/E-mediated decreases in Alcian blue binding, total hexose, sialic acid, and collagen in the gastric tissue, suggesting BOE attenuates the gastric damage via preserving the integrity of gastric mucus. Moreover, BOE significantly decreased histamine level in the plasma and reduced mRNA levels associated with secreting gastric acid. Furthermore, BOE inhibited myeloperoxidase activity and suppressed nuclear factor-κB mRNA and its dependent inflammatory genes expression induced by H/E. BOE also strengthened antioxidant enzyme activity, with a mitigating H/E-mediated increase in malondialdehyde level of the gastric tissue. Thus, these results suggest that BOE has the potential to protect the gastric tissue via inhibiting gastric acid secretion, inflammation, and oxidative stress.
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Niewęgłowski, Kacper, Natalia Wilczek, Michał Rycharski, and Julita Niewęgłowska. "Vonoprazan - a new drug for inhibiting gastric acid secretion." Journal of Education, Health and Sport 12, no. 8 (August 24, 2022): 661–70. http://dx.doi.org/10.12775/jehs.2022.12.08.068.

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Introduction and purpose Vonoprazan is a potassium-competent acid blocker (P-CAB). It has the potential to be an alternative to proton pump inhibitors (PPIs) as it inhibits hydrochloric acid secretion. The mechanism of action is different than PPIs - vonoprazan reversibly inhibits gastric H+, K+-ATPase, while PPIs irreversibly. Vonoprazan is approved for use in Japan and the US. The aim of the study was to review articles on the use of vonoprazan instead of PPIs in the treatment of acid-related gastrological diseases and to present the results obtained. A brief description of the state of knowledge Vonoprazan is used in the treatment of acid-related gastrological diseases. The 20 mg dose is suitable for most diseases, such as treatment of ulcers during low-dose aspirin treatment, post-endoscopic submucosal dissection (post-ESD) ulcers, erosive esophagitis (EE) in gastroesophageal reflux disease (GERD), and Helicobacter pylori eradication. Summary Researches suggest that the drug is an alternative for PPIs and can be used instead of them. The main advantage of this drug over PPIs is that it works faster, more potent and long-lasting. Studies suggest that vonoprazan can be use to treatment of the acid-related diseases and may be a better choice than PPIs. Vonoprazan may have a particular use in the treatment of PPI-refractory GERD. In post-ESD ulcers, a significant benefit in treatment effects of vonoprazan over PPIs cannot be clearly concluded.
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Zou, Yonghui, Yiwu Yuan, Qi Zhou, Zhenqi Yue, Jiang Liu, Luojun Fan, Hesong Xu, and Lin Xin. "The Role of Methionine Restriction in Gastric Cancer: A Summary of Mechanisms and a Discussion on Tumor Heterogeneity." Biomolecules 14, no. 2 (January 30, 2024): 161. http://dx.doi.org/10.3390/biom14020161.

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Gastric cancer is ranked as the fifth most prevalent cancer globally and has long been a topic of passionate discussion among numerous individuals. However, the incidence of gastric cancer in society has not decreased, but instead has shown a gradual increase in recent years. For more than a decade, the treatment effect of gastric cancer has not been significantly improved. This is attributed to the heterogeneity of cancer, which makes popular targeted therapies ineffective. Methionine is an essential amino acid, and many studies have shown that it is involved in the development of gastric cancer. Our study aimed to review the literature on methionine and gastric cancer, describing its mechanism of action to show that tumor heterogeneity in gastric cancer does not hinder the effectiveness of methionine-restricted therapies. This research also aimed to provide insight into the inhibition of gastric cancer through metabolic reprogramming with methionine-restricted therapies, thereby demonstrating their potential as adjuvant treatments for gastric cancer.
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Xing, Yu, Zi-Li Zhang, Zhi-Ying Ding, Wei-Liang Song, and Tong Li. "Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports." World Journal of Clinical Cases 11, no. 27 (September 26, 2023): 6483–90. http://dx.doi.org/10.12998/wjcc.v11.i27.6483.

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In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor. The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids. An abundant supply of amino acids is important for cancer to maintain its proliferative driving force. Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes. Therefore, it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer. This article reviews several specific amino acid metabolism characteristics in colorectal cancer.
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Pinto, Diana, Ana Margarida Silva, Stefano Dall’Acqua, Stefania Sut, Anna Vallverdú-Queralt, Cristina Delerue-Matos, and Francisca Rodrigues. "Simulated Gastrointestinal Digestion of Chestnut (Castanea sativa Mill.) Shell Extract Prepared by Subcritical Water Extraction: Bioaccessibility, Bioactivity, and Intestinal Permeability by In Vitro Assays." Antioxidants 12, no. 7 (July 12, 2023): 1414. http://dx.doi.org/10.3390/antiox12071414.

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Chestnut shells (CSs) are an appealing source of bioactive molecules, and constitute a popular research topic. This study explores the effects of in vitro gastrointestinal digestion and intestinal permeability on the bioaccessibility and bioactivity of polyphenols from CS extract prepared by subcritical water extraction (SWE). The results unveiled higher phenolic concentrations retained after gastric and intestinal digestion. The bioaccessibility and antioxidant/antiradical properties were enhanced in the following order: oral < gastric ≤ intestinal digests, attaining 40% of the maximum bioaccessibility. Ellagic acid was the main polyphenol in the digested and undigested extract, while pyrogallol–protocatechuic acid derivative was only quantified in the digests. The CS extract revealed potential mild hypoglycemic (<25%) and neuroprotective (<75%) properties before and after in vitro digestion, along with upmodulating the antioxidant enzymes’ activities and downregulating the lipid peroxidation. The intestinal permeation of ellagic acid achieved 22.89% after 240 min. This study highlighted the efficacy of the CS extract on the delivery of polyphenols, sustaining its promising use as nutraceutical ingredient.
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Saito, Makoto, Akio Mori, Sayaka Kajikawa, Emi Yokoyama, Minoru Kanaya, Koh Izumiyama, Masanobu Morioka, Takeshi Kondo, Zen-Ichi Tanei, and Ai Shimizu. "Helicobacter pylori eradication treatment for primary gastric diffuse large B-cell lymphoma: A single-center analysis." World Journal of Clinical Cases 11, no. 27 (September 26, 2023): 6424–30. http://dx.doi.org/10.12998/wjcc.v11.i27.6424.

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In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor. The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids. An abundant supply of amino acids is important for cancer to maintain its proliferative driving force. Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes. Therefore, it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer. This article reviews several specific amino acid metabolism characteristics in colorectal cancer.
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7

Karateev, A. E., Е. Yu Pogozheva, V. N. Amirdzhanova, and Е. S. Filatova. "Hyaluronic acid preparations in the treatment of osteoarthritis: is it clear to us?" Modern Rheumatology Journal 12, no. 3 (September 16, 2018): 40–52. http://dx.doi.org/10.14412/1996-7012-2018-3-40-52.

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Osteoarthritis (OA) is a progressive joint disease that causes persistent pain, limited joint function, disability, and loss of social activity. One of the most popular OA treatment options is intra-articular (I/A) hyaluronic acid (HA) injections. This procedure was introduced into clinical practice in the early 1980s and is used universally. To date, there is no consensus on the therapeutic value of HA. Many investigations confirm that HA is effective as not only a symptomatic agent, but also a structure-modifying one. Some works also show that the effect of HA is equal or only slightly superior to that of placebo (I/A saline injection). The review describes the mechanism of action and comparative efficacy of various (lowand high-molecular weight) HA preparations, as well as the safety of their use in real clinical practice.
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Popescu, Andrada L., Raluca S. Costache, Sandica Bucurica, Mihaita Patrasescu, Vasile D. Balaban, Florin A. Savulescu, Mariana Jinga, Florentina Ionita-Radu, and Carmen Fierbinteanu-Braticevici. "Laparoscopic sleeve gastrectomy and esophageal motility." Romanian Journal of Military Medicine 123, no. 3 (August 1, 2020): 190–95. http://dx.doi.org/10.55453/rjmm.2020.123.3.7.

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Laparoscopic sleeve gastrectomy (LSG) is becoming popular between the bariatric procedures. There are few studies available in the literature about LSG impact on esophageal motility, with debatable results. Technically, it modifies the anatomy of the esophago-gastric junction; it can damage the phreno-esophageal ligament and decrease the lower esophageal sphincter pressure that will predispose to reflux. Gastroesophageal reflux disease (GERD) is already common in obese patients due to frequent hiatal hernia, high intraabdominal pressure, increased transient lower esophageal sphincter relaxations (TLESR), altered esophageal motility and poor esophageal clearance. LSG can worsen gastroesophageal reflux disease, but also the weight loss achieved after it and the decrease of acid production in the small gastric pouch will probably reduce the GERD symptoms. Dysphagia and odynophagia were reported after sleeve gastrectomy, but usually associated with anatomical narrowing of the gastric sleeve, caused by esophageal dismotility or secondary to diabetes mellitus, low tiamine level, the use of opioids and non-steroidal anti-inflammatory drugs, even hypothyroidism. In addition to upper GI tract endoscopy, high-resolution esophageal manometry (HRM) should be required for all patients planning to undergo a LSG, and in the follow-up period according to the contractility pattern.
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Boujbiha, Mohamed Ali, Hassiba Chahdoura, Khaoula Adouni, Borhane Eddine Cherif Ziani, Mejdi Snoussi, Yasmine Chakroun, María Ciudad-Mulero, et al. "Wild Vitex agnus-castus L.: Phytochemical Characterization, Acute Toxicity, and Bioactive Properties." Molecules 28, no. 13 (June 29, 2023): 5096. http://dx.doi.org/10.3390/molecules28135096.

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Wild Vitex agnus-castus (VAC) is a Mediterranean plant that is rich in bioactive metabolites. This study aimed to validate, for the first time, the beneficial use of VAC fruits and fruit decoctions (VFDs) through in vitro and in vivo trials. Forty-one volatile components were detected in VAC fruits, with 1,8-cineole (30.3%) comprising the majority. The antioxidant activity of VFD was measured by using different in vitro methods (EC50 of 0.16 mg/mL by β-carotene bleaching inhibition assay) and by measuring the DNA protection power. Using the disc diffusion assay, the antimicrobial activity of VFD was evaluated, and it exhibited a noticeable anticandidal activity. VFD did not cause any toxicity or mortality in rats treated with doses > 200 mg/kg. Using the acetic acid writhing test, the antinociceptive activity of VFD was measured. Our results showed that VFD at 200 mg/kg exhibited a higher analgesic activity (81.68%) than acetylsalicylic acid used as a positive control (74.35%). Its gastroprotective ability was assessed by HCl/ethanol-induced gastric lesions, which were remarkably inhibited (84.62%) by intraperitoneal administration of VFD. This work helps to validate the popular use of VAC to treat nociceptive, inflammatory, and gastric disorders and encourages researchers to further investigate the identification of pharmacological compounds from this species.
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Sivanandan, Anagha. "Role of Music as a Therapeutic Measure in Women’s Health." International Research Journal of Ayurveda & Yoga 05, no. 10 (2022): 124–29. http://dx.doi.org/10.47223/irjay.2022.51020.

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Background: Music is such an art form that conveys emotions and perceptions even without using a language. The research activities focusing on the effects of art forms on health and well-being has been evidently increasing over the past two decades. Music therapy is a widely accepted and popular form for improving health through arts. Studies have shown that women being more sensitive and sentimental can be influenced more easily by music. Materials and Methods: Review of relevant literature from modern medical science, Ayurvedic classics, text books of Indian Musicology, previous research works, articles published in peer reviewed journals and other genuine sources of internet. Results: Music plays a significant role in improving the health and wellbeing of a female both in preventive and therapeutic aspects. Discussion: Music being the product of Akasha and Vayu Mahabhuta is capable of controlling the bodily Vata Dosha. Ayurveda consider music as a means to tackle Pitta Dosha mainly. Previous research works have shown the effect of Indian classical music on gastric and allied secretions in digestive system where there is a major role for Pitta Dosha. The coordinated activity of Hypothalamo- Pituitary- Ovarian Axis (HPO Axis) is responsible for normal menstrual and reproductive mechanism in females where Vata and Pitta are having the main roles. So music can play an appreciable role in maintaining the normal functions in HPO axis.
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Books on the topic "Gastric acid – Popular works"

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Lane, Lenard, ed. Why stomach acid is good for you: Natural relief from heartburn, indigestion, reflux, and GERD. New York: M. Evans, 2001.

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Inc, NetLibrary, ed. Tell me what to eat if I have acid reflux: Nutrition you can live with. Franklin Lakes, NJ: New Page Books, 2002.

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Shah, Manish A. 100 questions & answers about gastric cancer. Sudbury, Mass: Jones and Bartlett Publishers, 2008.

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SAM. The acid: On sustained experiment with lysergic acid diethylamide, or LSD. London: Vision, 2009.

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Parker, James N., and Philip M. Parker. The official patient's sourcebook on rapid gastric emptying. Edited by Icon Group International Inc and NetLibrary Inc. San Diego, Calif: Icon Health Publications, 2002.

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Oppenheim, Michael. The complete book of better digestion: A gut-level guide to gastric relief. Emmaus, Pa: Rodale Press, 1990.

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Outpatient weight-loss surgery: Safe and successful weight loss with modern bariatric surgery : a Sasse guide. Reno, Nev: 360 Pub., 2009.

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Koufman, Jamie. Dropping acid: The reflux diet cookbook & cure. [New York, N.Y.?]: Reflux Cookbooks, L.L.C., 2010.

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Lipski, Elizabeth. Digestion connection: The simple, natural plan to combat diabetes, heart disease, osteoporosis, arthritis, acid reflux--and more! [New York]: Rodale Inc., 2013.

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Shimberg, Elaine Fantle. Coping with chronic heartburn: What you need to know about acid reflux and GERD. New York: St. Martin's Press, 2001.

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Book chapters on the topic "Gastric acid – Popular works"

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Li, Jie Jack. "Esomeprazole (Nexium)." In Top Drugs. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780199362585.003.0019.

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Gastric acid, hydrochloric acid (HCl), is essential to our digestion. It helps break down proteins, fats, and starches in our food into nutrients such as amino acids and carbohydrates that our body can absorb. Alas, there can be too much of a good thing. Too much secretion of gastric acid for too long can cause heartburn or acid reflux, also known as gastroesophageal reflux disease (GERD). In addition, having too much gastric acid for too long will damage the mucosa of the stomach and may cause ulcer and even stomach cancers! While the exact pathogenesis of ulcers is not known, theories abound. It is still a popular belief that ulcer is caused by stress. Thirty years ago, the discovery of Helicobacter pylori demonstrated that the bacterium contributes to gastritis and peptic ulcers. Regardless of the root of stomach ulcers, they are closely associated with excessive secretion of gastric acid, so that was what early ulcer drugs intended to treat. Dozens of antacids are on the market to neutralize excess HCl: For instance, Mylanta and Maalox contain Al(OH)3 and Mg(OH)2. Tums contains CaCO3. Alka-Seltzer contains NaHCO3 (baking soda). However, antacids only treat the symptoms of excessive acid secretion, and are therefore only effective as a short-term treatment. A better therapy would treat the causation of excessive acid secretion. Histamine-2 receptor antagonists work by blocking the receptors that are responsible for excessive acid secretion: the histamine- 2 receptors. As a consequence, they are more efficacious and have fewer adverse effects in comparison to conventional antacids. The fact that histamine stimulates gastric acid secretion in the stomach was first observed by Popielski in the 1920s. Popielski studied under Pavlov, who won the Nobel Prize (for Physiology or Medicine) in 1904 for his studies in digestive system, but who is now better known for his classical dog-conditioning experiments. As an independent researcher at the University of Kraków, Popielski discovered that histamine was a stimulant of gastric glands, and acted directly without the involvement of vagal nerves. After injecting histamine subcutaneously into gastric fistulas in dogs, Popielski observed copious gastric acid secretion and extremely high acidity in the dogs’ stomachs.
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