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1

Jiang, Dongneng, Liqun Zhang, Fei Liu, Chang Liu, Linlin Liu, and Xiaoyun Pu. "An electrochemiluminescence sensor with dual signal amplification of Ru(bpy)32+based on PtNPs and glucose dehydrogenase for diagnosis of gas gangrene." RSC Advances 6, no. 24 (2016): 19676–85. http://dx.doi.org/10.1039/c5ra27241f.

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Gas gangrene is a bacterial infection that produces gas in tissues in gangrene.C. perfringenswith alpha-toxin plays a key role in gas gangrene. Detection ofC. perfringensis highly important in clinical diagnosis of gas gangrene.
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2

Stephens, Lt Mark B. "Gas gangrene." Postgraduate Medicine 99, no. 4 (April 1996): 217–24. http://dx.doi.org/10.1080/00325481.1996.11946109.

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3

Schexnayder, Stephen M., and Sarah G. Klein. "Gas Gangrene." New England Journal of Medicine 350, no. 25 (June 17, 2004): 2603. http://dx.doi.org/10.1056/nejmicm980151.

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4

Pitt, M., N. J. Purser, Gilles Bouachour, JeanPaul Gouello, Patrick Harry, and Philippe Alquier. "Gas gangrene." Lancet 347, no. 9008 (April 1996): 1116–17. http://dx.doi.org/10.1016/s0140-6736(96)90315-3.

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5

Coleman, D. J., and A. G. Batchelor. "Gas gangrene." BMJ 296, no. 6636 (June 4, 1988): 1600–1601. http://dx.doi.org/10.1136/bmj.296.6636.1600-a.

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6

Golledge, C., A. Keil, and T. McKenzie. "Gas gangrene." BMJ 296, no. 6636 (June 4, 1988): 1601. http://dx.doi.org/10.1136/bmj.296.6636.1601.

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7

Bignardi, G. E. "Gas gangrene." BMJ 296, no. 6637 (June 11, 1988): 1671. http://dx.doi.org/10.1136/bmj.296.6637.1671.

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8

Maddocks, J. L. "Gas gangrene." BMJ 297, no. 6642 (July 16, 1988): 204. http://dx.doi.org/10.1136/bmj.297.6642.204-c.

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9

Lehner, P. J., and H. Powell. "Gas gangrene." BMJ 303, no. 6796 (July 27, 1991): 240–42. http://dx.doi.org/10.1136/bmj.303.6796.240.

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10

Mercer, N., and D. M. Davies. "Gas gangrene." BMJ 303, no. 6806 (October 5, 1991): 854–55. http://dx.doi.org/10.1136/bmj.303.6806.854-b.

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11

Owen, E. R. T. C., and P. J. Lehner. "Gas gangrene." BMJ 303, no. 6806 (October 5, 1991): 854–55. http://dx.doi.org/10.1136/bmj.303.6806.854-c.

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12

Echigoya, Ryosuke, Akira Kuriyama, and Noriyuki Umakoshi. "Hepatic Gas Gangrene." Internal Medicine 54, no. 10 (2015): 1319. http://dx.doi.org/10.2169/internalmedicine.54.4149.

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13

Sorbie, Charles. "Atraumatic Gas Gangrene." Orthopedics 26, no. 10 (October 2003): 1005. http://dx.doi.org/10.3928/0147-7447-20031001-04.

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14

Valentinecol, Elizabeth G. "Nontraumatic Gas Gangrene." Annals of Emergency Medicine 30, no. 1 (July 1997): 109–11. http://dx.doi.org/10.1016/s0196-0644(97)70121-5.

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15

Cour, Morten, Annette Nørgaard, Jan Ulrik Prause, and Erik Scherfig. "Gas gangrene panophthalmitis." Acta Ophthalmologica 72, no. 4 (May 27, 2009): 524–28. http://dx.doi.org/10.1111/j.1755-3768.1994.tb02808.x.

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16

Lyon, David B., and Bradley N. Lemke. "Eyelid Gas Gangrene." Ophthalmic Plastic & Reconstructive Surgery 5, no. 3 (September 1989): 212–15. http://dx.doi.org/10.1097/00002341-198909000-00013.

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17

Delbridge, M. S., E. P. L. Turton, and R. C. Kester. "Spontaneous fulminant gas gangrene." Emergency Medicine Journal 22, no. 7 (June 24, 2005): 520–21. http://dx.doi.org/10.1136/emj.2003.013144.

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18

Kirk, C. R. "Gas gangrene: Authors' reply." BMJ 296, no. 6637 (June 11, 1988): 1671. http://dx.doi.org/10.1136/bmj.296.6637.1671-a.

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19

Jamieson, N. F. "Gas gangrene after colonoscopy." Postgraduate Medical Journal 77, no. 903 (January 1, 2001): 47–49. http://dx.doi.org/10.1136/pmj.77.903.47.

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20

Gentile, J., S. Gentile, O. Garcia Allende, and M. Sparo. "Spontaneous Hepatic Gas Gangrene." Anaerobe 5, no. 3-4 (June 1999): 395–96. http://dx.doi.org/10.1006/anae.1999.0229.

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21

Tsimkhes, I. "Gas gangrene after drug injections. Dr. Herbert lunghans (Deutsch.medic. Wochenschr. 1933. No. 22)." Kazan medical journal 29, no. 10 (January 12, 2022): 837. http://dx.doi.org/10.17816/kazmj90161.

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Gas gangrene after drug injections. Dr. Herbert liinghans (Deutsch.medic. Wochenschr. 1933. No. 22), after analyzing his case of gas gangrene after an injection of digipurate, cites from the literature 60 cases where gas gangrene developed at the injection site of the same medicinal substances.
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22

Bakhshi, Girish D., Owais Ahmed Patel, Dinesh Pawar, and Jessicka Shah. "Non-clostridial gas gangrene of a diabetic foot with COVID-19 infection." International Surgery Journal 7, no. 9 (August 27, 2020): 3156. http://dx.doi.org/10.18203/2349-2902.isj20203816.

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Gas gangrene is a manifestation of soft tissue infection by clostridial group of bacteria. Non-clostridial gas gangrene is uncommon and seen rarely in diabetics. In the era of COVID-19 pandemic where COVID-19 itself induces hyperglycemia non clostridial gas gangrene may arise due to altered immunity. We present a case of non clostridial gas gangrene of lower limb in a middle aged person who was not a known diabetic. A brief case report with review of literature is presented.
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23

Asao, Rin, Kazumasa Nishida, Hiromichi Goto, Yoshikazu Goto, Noriatsu Ichiba, and Isao Ohsawa. "Postmortem computed tomography of gas gangrene with aortic gas in a dialysis patient." CEN Case Reports 9, no. 4 (April 22, 2020): 308–12. http://dx.doi.org/10.1007/s13730-020-00456-y.

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Abstract Recently, postmortem imaging is sometimes used as an alternative to conventional autopsy. However, there are few case reports of postmortem imaging of dialysis patients. Here, we report a fatal case of gas gangrene involving a 76-year-old man who underwent dialysis. He died suddenly before a diagnosis could be established. Immediately after his death, postmortem computed tomography (PMCT) revealed gas accumulation in his right upper extremity and ascending aorta. Gas gangrene progresses rapidly and may sometimes result in sudden death before it is diagnosed. In this case, PMCT findings were useful to diagnose gas gangrene. Intravascular gas is a common finding on PMCT and is generally caused by cardiopulmonary resuscitation and decomposition. However, the detection of gas in the ascending aorta by PMCT was not described previously. Moreover, Gram stain and culture of the exudate showed anaerobic Gram-positive bacilli which suggested that the gas generation in the blood was caused by Clostridia species. To the best our knowledge, this is the first report of a dialysis patient whose cause of death was determined as gas gangrene using PMCT.
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24

Ying, Zhimin, Min Zhang, Shigui Yan, and Zhong Zhu. "Gas Gangrene in Orthopaedic Patients." Case Reports in Orthopedics 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/942076.

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Clostridial myonecrosis is most often seen in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. Since 1953 cases of gas gangrene have been reported in orthopaedic patients including open fractures, closed fractures, and orthopaedic surgeries. We present a case of 55-year-old obese woman who developed rapidly progressive gas gangrene in her right leg accompanied by tibial plateau fracture without skin lacerations. She was diagnosed with clostridial myonecrosis and above-the-knee amputation was carried out. This patient made full recovery within three weeks of the initial episode. We identified a total of 50 cases of gas gangrene in orthopaedic patients. Several factors, if available, were analyzed for each case: age, cause of injury, fracture location, pathogen, and outcome. Based on our case report and the literature review, emergency clinicians should be aware of this severe and potentially fatal infectious disease and should not delay treatment or prompt orthopedic surgery consultation.
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25

MASAKI, Takayuki, Hozo UMEHASHI, Hiroshi MIYAZAKI, Makoto TAKANO, Kiyotaka YAMAKAWA, and Shinichi NAKAMURA. "CLOSTRIDIUM ABSONUM FROM GAS GANGRENE." Japanese Journal of Medical Science and Biology 41, no. 1 (1988): 27–30. http://dx.doi.org/10.7883/yoken1952.41.27.

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26

SEIDEL, MONIKA, MICHAEL WEISS, THOMAS NICOLAI, REINHARD ROOS, RAINER GRANTZOW, and BERND H. BELOHRADSKY. "Gas gangrene and congenital agranulocytosis." Pediatric Infectious Disease Journal 9, no. 6 (June 1990): 437–39. http://dx.doi.org/10.1097/00006454-199006000-00014.

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27

McCloskey, Malachy, and Vincent HS Low. "CT of pancreatic gas gangrene." Australasian Radiology 40, no. 1 (February 1996): 75–76. http://dx.doi.org/10.1111/j.1440-1673.1996.tb00351.x.

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28

JOSEPHEA, A. "Gas gangrene of the pancreas." American Journal of Gastroenterology 96, no. 9 (September 2001): S211. http://dx.doi.org/10.1016/s0002-9270(01)03450-5.

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29

Lindsay, D. "Clostridium perfringens and gas gangrene." Journal of Trauma: Injury, Infection, and Critical Care 26, no. 12 (December 1986): 1156. http://dx.doi.org/10.1097/00005373-198612000-00031.

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30

Hengster, Paul, and Heinz Pernthaler. "Gas gangrene: necropsy is imperative." Lancet 347, no. 9000 (February 1996): 553. http://dx.doi.org/10.1016/s0140-6736(96)91189-7.

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31

Ketterl, R., T. Beckurts, J. Kovacs, B. Stu¨binger, R. Hipp, and B. Claudi. "Gas-gangrene following arthroscopic surgery." Arthroscopy: The Journal of Arthroscopic & Related Surgery 5, no. 1 (January 1989): 79–83. http://dx.doi.org/10.1016/0749-8063(89)90098-4.

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32

Kashiura, Masahiro, Kazuki Miyazaki, Hidenobu Fujita, and Yuichi Hamabe. "Blackish haematuria and gas gangrene." Intensive Care Medicine 42, no. 9 (June 7, 2016): 1498–99. http://dx.doi.org/10.1007/s00134-016-4412-6.

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33

Sawhney, R., J. H. Rees, and S. K. Markowitz. "Clostridial gas gangrene complicating leukemia." Abdominal Imaging 19, no. 5 (September 1994): 451–52. http://dx.doi.org/10.1007/bf00206938.

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34

Ishizuka, Tetsuo, Tetsuo Senba, Yasushi Ota, and Ken Ito. "Gas Gangrene in the Neck." Practica Oto-Rhino-Laryngologica 86, no. 1 (1993): 113–18. http://dx.doi.org/10.5631/jibirin.86.113.

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35

Kirk, C. R., J. C. Dorgan, and C. A. Hart. "Gas gangrene: a cautionary tale." BMJ 296, no. 6631 (April 30, 1988): 1236–37. http://dx.doi.org/10.1136/bmj.296.6631.1236.

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36

Mayer, Gabriel, and Rodney Kang. "Gas gangrene, diabetes, and cholecystitis." American Journal of Emergency Medicine 3, no. 1 (January 1985): 42–45. http://dx.doi.org/10.1016/0735-6757(85)90011-7.

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37

Junior, Carlos A. Oliveira, Rodrigo O. S. Silva, Francisco C. F. Lobato, Mauricio A. Navarro, and Francisco A. Uzal. "Gas gangrene in mammals: a review." Journal of Veterinary Diagnostic Investigation 32, no. 2 (February 21, 2020): 175–83. http://dx.doi.org/10.1177/1040638720905830.

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Gas gangrene is a necrotizing infection of subcutaneous tissue and muscle that affects mainly ruminants and horses, but also other domestic and wild mammals. Clostridium chauvoei, C. septicum, C. novyi type A, C. perfringens type A, and C. sordellii are the etiologic agents of this disease, acting singly or in combination. Although a presumptive diagnosis of gas gangrene can be established based on clinical history, clinical signs, and gross and microscopic changes, identification of the clostridia involved is required for confirmatory diagnosis. Gross and microscopic lesions are, however, highly suggestive of the disease. Although the disease has a worldwide distribution and can cause significant economic losses, the literature is limited mostly to case reports. Thus, we have reviewed the current knowledge of gas gangrene in mammals.
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38

Dylewski, Joe, Robert Drummond, and John Rowen. "A case of Clostridium septicum spontaneous gas gangrene." CJEM 9, no. 02 (March 2007): 133–35. http://dx.doi.org/10.1017/s1481803500014950.

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ABSTRACT Severe skin and soft tissue infections (SSTIs) are often life-threatening emergencies that require a rapid diagnosis. Gas gangrene is one of the most fulminant types of SSTI and is usually caused by Clostridium perfringens' contamination of an open wound. Although gas gangrene is usually associated with fecally contaminated wounds, “spontaneous” cases occur and are most commonly caused by Clostridium (C.) septicum. We report a case of spontaneous gas gangrene caused by C. septicum that only became manifest while the patient was being monitored in the emergency department. We also review the diagnosis and treatment aspects of this entity.
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39

Sacco, Sofia C., Joaquín Ortega, Mauricio A. Navarro, Karina C. Fresneda, Mark Anderson, Leslie W. Woods, Janet Moore, and Francisco A. Uzal. "Clostridium sordellii–associated gas gangrene in 8 horses, 1998–2019." Journal of Veterinary Diagnostic Investigation 32, no. 2 (October 4, 2019): 246–51. http://dx.doi.org/10.1177/1040638719877844.

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Gas gangrene occurs in several animal species and is caused by one or more clostridial species. In horses, the disease is most often caused by Clostridium perfringens type A. Although Clostridium sordellii has been associated with gas gangrene in ruminants and humans, cases of the disease associated with this microorganism have not been described in horses, to our knowledge. We report herein 8 cases of gas gangrene caused by C. sordellii in horses. These cases were characterized by myonecrosis and cellulitis, associated with systemic changes suggestive of toxic shock. The diagnosis was confirmed by gross and microscopic changes combined with anaerobic culture, fluorescent antibody test, immunohistochemistry, and/or PCR. The predisposing factor in these cases was an injection or a traumatic skin injury. C. sordellii should be considered as a possible etiologic agent in cases of gas gangrene in horses.
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40

Niimi, Masanori, Yosifumi Ikeda, Shigenao Kan, and Hiroshi Takami. "Gas Gangrene in Patient with Atherosclerosis Obliterans." Asian Cardiovascular and Thoracic Annals 10, no. 2 (June 2002): 178–80. http://dx.doi.org/10.1177/021849230201000223.

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Clostridia are the main cause of nontraumatic spontaneous gas gangrene. Poor blood flow due to arterial occlusion exacerbates the anaerobic condition. Fulminant gas gangrene in a 54-year-old man with atherosclerosis obliterans was treated by revascularization of the iliac artery using endarterectomy, and his gangrenous lower leg was amputated. However, he died from renal failure.
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41

Panchbhavi, Vinod K., and Scott E. Hecox. "All That Is Gas Is Not Gas Gangrene." Journal of Bone & Joint Surgery 88, no. 6 (June 2006): 1345–48. http://dx.doi.org/10.2106/jbjs.e.01172.

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42

PANCHBHAVI, VINOD K., and SCOTT E. HECOX. "ALL THAT IS GAS IS NOT GAS GANGRENE." Journal of Bone and Joint Surgery-American Volume 88, no. 6 (June 2006): 1345–48. http://dx.doi.org/10.2106/00004623-200606000-00025.

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43

Komarovskaya, E. I., and O. V. Perelygina. "Current incidence of certain clostridial infections: gas gangrene and tetanus." BIOpreparations. Prevention, Diagnosis, Treatment 21, no. 1 (March 13, 2021): 31–38. http://dx.doi.org/10.30895/2221-996x-2021-21-1-31-38.

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Clostridial myonecrosis or gas gangrene (myonecrosis) and tetanus are relatively rare nowadays, but they are still considered serious conditions associated with poor prognosis and high mortality. Life-threatening infections caused by Clostridium species have been known and studied for centuries, as they differed from other infections in terms of typical clinical manifestations, challenges of therapy and prevention. The aim of the study was to analyse the global incidence of gas gangrene and tetanus and challenges of prevention and treatment of these diseases. The review of up-to-date scientific literature demonstrated that gas gangrene continues to be a problem due to its rapid progression and challenging treatment. There are two main forms of the disease—traumatic and spontaneous. Traumatic gas gangrene is usually caused by C. perfringens, C. septicum, C. novyi (oedematiens), or C. histolyticum. Its incidence increases dramatically during wars, natural disasters, and other calamities. The literature review demonstrated that over the past 40 years there has been a rise in the frequency of spontaneous gas gangrene caused by C. septicum in people with compromised immune systems, in injecting drug users, and in women during various gynecological procedures and during normal delivery. Despite the effectiveness of the tetanus immunisation programme, the infection remains widespread in countries with insufficient vaccination coverage. The risk of tetanus in developed countries is high among elderly unvaccinated or partially vaccinated people, among injecting drug users, and vaccine refusers. The paper describes some clinical cases of gas gangrene and tetanus which demonstrate problems associated with challenging diagnosis and treatment, low awareness among primary healthcare personnel about mechanisms of anaerobic infection development, and anti-vaccination movement.
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44

Bajpai, Vijeta, Aishwarya Govindaswamy, Sonu Kumari Agrawal, Rajesh Malhotra, and Purva Mathur. "Clostridium sordelli as a cause of gas gangrene in a trauma patient." Journal of Laboratory Physicians 11, no. 01 (January 2019): 094–96. http://dx.doi.org/10.4103/jlp.jlp_108_18.

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AbstractGas gangrene is a necrotic infection of the skin and soft tissue that is associated with high mortality and often necessitating amputation to control the infection. Clostridial myonecrosis is most often cause of gas gangrene and usually present in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. The most common causative organism of clostridial myonecrosis is Clostridium perfringens followed by Clostridium septicum. Here, we are reporting an unusual case report of posttraumatic gas gangrene caused by Clostridium sordelli.
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45

Misiakos, Evangelos P., Nick Zabras, George Bagias, Panagiotis Tzanetis, Lignos Michail, Spyros Vasdekis, Paul Patapis, and Anastasios Machairas. "Uncommon Locations of Gas Gangrene Treated Successfully With Surgical Debridement and the Vacuum-Assisted Closure Device." International Surgery 101, no. 11-12 (December 1, 2016): 517–23. http://dx.doi.org/10.9738/intsurg-d-14-00296.1.

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Gas gangrene is a life-threatening condition implying necrosis of dermis and hypodermis, along with necrosis of the superficial muscular aponeurosis. Fournier s gangrene is a subtype of the disease affecting the perineal and genital area. The aim of this study is to analyze the clinical presentation, diagnosis, medical, and surgical treatment of three cases of gas gangrene affecting uncommon locations in the human body, treated with extensive surgical debridement followed by the vacuum assisted closure method in two of these cases. Three cases of gas gangrene affecting uncommon locations treated surgically in our Department are presented. In one case the perineal and scrotal region was infected with invasion of the lateral abdominal wall and the peritoneal cavity. In the second case the axillary regions were infected bilaterally and in the third case the left axillary and subscapular regions were infected after a left arm disarticulation. All cases were treated successfully with successive surgical debridement and/or the vacuum-assisted closure method. Gas gangrene is a curable disease if diagnosed early and treated effectively with successive surgical wound cleaning and debridement. The vacuum assisted closure method can be helpful in promoting wound healing.
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46

Suno, Y., H. Kashiwagi, Y. Igarashi, T. Murata, N. Isogai, R. Shimoyama, J. Kawachi, T. Kawahara, and K. Watanabe. "Liver Gas Gangrene after Biliary Surgery." HPB 23 (2021): S208. http://dx.doi.org/10.1016/j.hpb.2020.11.520.

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47

Tohma, Yoshiki, Naruhiro Son, Tomoko Miyazawa, Muneo Ohta, Masaki Fujita, and Kazuya Sakata. "Fulminant spontaneous intrahepatic clostridial gas gangrene." Nihon Kyukyu Igakukai Zasshi 7, no. 1 (1996): 27–32. http://dx.doi.org/10.3893/jjaam.7.27.

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48

Parik, Madhav, Ramanuj Mukherjee, Pritha Roy, and Gouri Mukhopadhyay. "Gas gangrene complicating an open fracture." National Medical Journal of India 32, no. 2 (2019): 123. http://dx.doi.org/10.4103/0970-258x.275359.

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49

Narang, Tarun, Sunil Dogra, and Inderjeet Kaur. "Gas gangrene in a leprosy patient." Leprosy Review 80, no. 1 (March 1, 2009): 89–91. http://dx.doi.org/10.47276/lr.80.1.89.

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50

Kurokawa, Hiroaki, Katsuhiro Aida, Motoki Sonohata, Tomoko Higo, and Takao Hotokebuchi. "A Case of Nontraumatic Gas Gangrene." Orthopedics & Traumatology 49, no. 4 (2000): 1029–31. http://dx.doi.org/10.5035/nishiseisai.49.1029.

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