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Academic literature on the topic 'Ganoderma lucidum'

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Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Ganoderma lucidum"

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Hajjaj, Hassan, Catherine Macé, Matthew Roberts, Peter Niederberger, and Laurent B. Fay. "Effect of 26-Oxygenosterols from Ganoderma lucidum and Their Activity as Cholesterol Synthesis Inhibitors." Applied and Environmental Microbiology 71, no. 7 (July 2005): 3653–58. http://dx.doi.org/10.1128/aem.71.7.3653-3658.2005.

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ABSTRACT Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine. We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro. We also investigated the site of inhibition in the cholesterol synthesis pathway. We found that these oxygenated sterols from G. lucidum inhibited cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. By incorporation of 24,25-dihydro-[24,25-3H2]lanosterol and [3-3H]lathosterol in the presence of ganoderol A, we determined that the point of inhibition of cholesterol synthesis is between lanosterol and lathosterol. These results demonstrate that the lanosterol 14α-demethylase, which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited by the 26-oxygenosterols from G. lucidum. These 26-oxygenosterols could lead to novel therapeutic agents that lower blood cholesterol.
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Chen, Deng-Hai, Jian-Yuan Wang, Mon-Tarng Chen, Yen-Chun Liu, and Kuang-Dee Chen. "The Triterpenoid High-Performance Liquid Chromatography Analytical Profiles of the Mycelia of Ganoderma lucidum (lingzhi)." Microbiology Research 14, no. 3 (September 14, 2023): 1353–63. http://dx.doi.org/10.3390/microbiolres14030092.

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(1) Background: Ganoderic acids (GAs) are specific triterpenes of Ganoderma lucidum. The HPLC fingerprint profile of GAs of the fruiting body is well known, but their mycelial fingerprinting remains unclear. (2) Methods: An ethanol extract of the mycelium of G. lucidum (YK-01) was further purified via preparative HPLC. The triterpenoid compositions for four strains of G. lucidum and one strain of G. formosanum (purple lingzhi) were analyzed using HPLC. (3) Results: Nineteen lanostane triterpenes, including five new triterpenes, GA-TP (1), ganodermic acid Jc (GmA-Jc) (2), GmA-Jd (3), GA-TQ1 (4), and ganoderal B1 (5), and fourteen known triterpenes 6–19 were isolated from the ethanol extract. Their structures were identified by mass and extensive NMR spectroscopy. A green chemical HPLC analytical method was developed using ethanol and acetic acid as a mobile phase, and all isolated compounds can be well separated. These triterpenes comprise a unique HPLC chromatograph of the G. lucidum mycelium. All four G. lucidum strains showed the same HPLC chromatographic pattern, whereas G. formosanum displayed a different pattern. Quantitation methods for ganoderic acid T (10) and S (12) were also validated. (4) Conclusions: The triterpenoid HPLC analytical method can be used to identify the G. lucidum species and to determine the contents of GA-T and GA-S.
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Osahon Stanley Usiobeigbe, Kingsley O. Airhomwanbor, Lucky Eromosele Omolumen, Raphael O. Ikyaagba, Ernest Asibor, and Daniella Damilola Ogunsina. "Effects of Garnoderma lucidum on Acetaminophen-Induced Liver Injury in Wistar Rats." World Journal of Advanced Research and Reviews 21, no. 3 (March 30, 2024): 2599–608. http://dx.doi.org/10.30574/wjarr.2024.21.3.0977.

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Introduction: Ganoderma lucidum is considered to be a medicinal mushroom, widely used to prevent or treat different types of diseases including cancer, cardiovascular disease and hepatic dysfunction. This study aimed to evaluate the effect of Ganoderma lucidum on acetaminophen-induced liver injury in wistar rats. Methods: Forty (40) male wistar rats were used for this study. Hepatoxicity was induced by oral administration of acetaminophenn (3000 mg/kg of body weight) for the last 21 consecutive days of the dietary of regimen Ganoderma lucidum. These rats were divided into eight cages each containing Five rats. Control Group 1 fed on feed and water only throughout the study, Group 2 received acetaminophen only, Group 3 received Acetaminophen + Standard drug (silymarin), Group 4 received Acetaminophen +100 mg/kg body weight of Ganoderma lucium extract, Group 5 received Acetaminophen + 200 mg/kg body weight of Ganoderma lucidum extract, Group 6 received Acetaminophen + 300 mg/kg body weight of Ganoderma lucidum extract , Group 7 received 100 mg/kg of Ganoderma lucidum extract, Group 8 received Acetaminophen+Standard Drug (silymarin) + 300 mg/kg body weight of Ganderma lucidum extract. Blood samples was collected via cardiac puncture within 24 hours of Sacrifice. The extent of the liver injury was determined by assessing the plasma levels of Tumor Necrosis Factor Alpha (TNF-α), Alpha Feto protein, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Total bilirubin (TB), Conjugated bilirubin (CB), Unconjugated Bilirubin (UB), Albumin, Gamma Glutamyl Transaminase (GGT) and total protein (TP) using spectrophotometric method and ELISA as appropriate. Results: Oral administration of Acetaminophen significantly increased the plasma levels of the parameters accessed, suggesting severe liver damage in the rats. However, the treatment of Ganoderma lucidum decreased these hepatotoxic indices at a significant level of P <0.01 for TNF-α, AFP, ALT, AST, UB, TB, GGT and ALP, while Albumin and Conjugated Bilirubin were significantly decreased at a level of (P<0.05) in the Ganoderma lucidum + Acetaminophen-administered group compared to those of the control group. Conclusion: Thus, the results of the present investigation demonstrates that the Ganoderma lucidum provides significant hepatoprotective activity against acetaminophen-induced liver injury in wistar rats.
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Kao, Chi, Amalini C. Jesuthasan, Karen S. Bishop, Marcus P. Glucina, and Lynnette R. Ferguson. "Anti-cancer activities of Ganoderma lucidum: active ingredients and pathways." Functional Foods in Health and Disease 3, no. 2 (February 9, 2013): 48. http://dx.doi.org/10.31989/ffhd.v3i2.65.

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Ganoderma lucidum, commonly referred to as Lingzhi, has been used in Asia for health promotion for centuries. The anti-cancer effects of G. lucidum have been demonstrated in both in vitro and in vivo studies. In addition, the observed anti-cancer activities of Ganoderma have prompted its usage by cancer patients alongside chemotherapy. The main two bioactive components of G. lucidum can be broadly grouped into triterpenes and polysaccharides. Despite triterpenes and polysaccharides being widely known as the major active ingredients, the different biological pathways by which they exert their anti-cancer effect remain poorly defined. Therefore, understanding the mechanisms of action may lead to more widespread use of Ganoderma as an anti-cancer agent. The aim of this paper is to summarise the various bioactive mechanisms that have been proposed for the anti-cancer properties of triterpenes and polysaccharides extracted from G. lucidum. A literature search of published papers on NCBI with keywords “Ganoderma” and “cancer” was performed. Among those, studies which specifically examined the anti-cancer activities of Ganoderma triterpenes and polysaccharides were selected to be included in this paper. We have found five potential mechanisms which are associated with the anti-cancer activities of Ganoderma triterpenes and three potential mechanisms for Ganoderma polysaccharides. In addition, G. lucidum has been used in combination with known anti-cancer agents to improve the anti-cancer efficacies. This suggests Ganoderma’s bioactive pathways may compliment that of anti-cancer agents. In this paper we present several potential anti-cancer mechanisms of Ganoderma triterpenes and polysaccharides which can be used for the development of Ganoderma as an anti-cancer agent.Keywords: Ganoderma lucidum, cancer, bioactive pathways, triterpene, polysaccharide
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Shin, Min-Ji, Hae-Jung Chae, Ji Won Lee, Man Hyung Koo, Hyun-Jin Kim, Jong Bae Seo, Shagin yanIllia, et al. "Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer." Evidence-Based Complementary and Alternative Medicine 2022 (November 8, 2022): 1–9. http://dx.doi.org/10.1155/2022/7404493.

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Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been recognized as an organism that suppresses tumors and inflammation; however, the molecular mechanisms induced by a triterpenoid in Ganoderma lucidum, Lucidumol A, have not yet been fully explored in CRC and inflammatory responses. To this end, we extracted Lucidumol A from Ganoderma lucidum and analyzed its anticancer effect and anti-inflammatory potential in CRC cell lines and RAW264.7 macrophage-derived cell lines, respectively. A series of in vitro experiments including cell survival, wound healing, and migration assays were performed to determine the role of Lucidumol A in the CRC cell line. We also analyzed inflammatory responses using qRT-PCR, Western Blot, and ELISA in RAW 264.7 macrophaged-derived cell lines exposed to various concentrations of Lucidumol A. Lucidumol A efficiently suppressed the metastatic potential of CRC at very low concentrations. Furthermore, significant anti-inflammatory activities were observed in Lucidumol A-treated RAW264.7 cells through modulation of inflammation-associated marker genes and cytokines. In conclusion, Lucidumol A plays an important role in Ganoderma lucidum-dependent tumor suppression and anti-inflammation, suggesting different strategies to treat CRC patients, and other diseases evoked by proinflammatory cytokines, despite the need to explore further its mechanism of action.
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MORENO, Henry, Alejandro MARTINEZ M., and Yoshinori FUJIMOTO. "ISOLATION AND IDENTIFICATION OF TWO STEROLS AND A TRITERPENE FROM DRY FRUITING BODIES OF <I>Ganoderma lucidum</I> CULTIVATED IN COLOMBIA." Vitae 18, no. 1 (May 17, 2011): 11–15. http://dx.doi.org/10.17533/udea.vitae.8772.

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Ganoderma lucidum is a medicinal mushroom belonging to Ganodermataceae family. It is known as “reishi” in Japan and is widely used in traditional Chinese medicine. Reported metabolites include polysaccharides and triterpenoids with different biological activities. In this paper isolation and identification of ergosterol, 5,6-dihydroergosterol and lucidumol-B, are described. These compounds were isolated from methanolic extract of fruiting bodies of Ganoderma lucidum cultivated in Colombia.
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Xia, Li Ya, Xiao Ting Li, Pei Yun Chen, and Yan Ping Pang. "Identification of Ganoderma Lucidum Spore Powder and Ganoderma Lucidum Powder Based on Near-Infrared Spectroscopy and Cluster Analysis." Advanced Materials Research 971-973 (June 2014): 280–83. http://dx.doi.org/10.4028/www.scientific.net/amr.971-973.280.

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In order to identify the Ganoderma lucidum spore powder and Ganoderma lucidum powder, diffuse reflectance spectroscopy of samples were collected by the Fourier near-infrared spectrometer. The spectroscopy was pretreated by vector normalization and then analyzed with chemometrics method. The data of near-infrared spectra in whole spectral region was analyzed by principal component analysis, then the first 5 scores was established cluster analysis model. The results show that this method can effectively identify Ganoderma lucidum spore powder and Ganoderma lucidum powder with the 100% accuracy rate. In conclusion, Ganoderma Lucidum Spore Powder and Ganoderma Lucidum Powder Based on Near-infrared Spectroscopy and Cluster Analysis.
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Nisa, Intan Chairun, and Brilliant Margalin. "Optimasi dan uji efektivitas ekstrak Ganoderma lucidum sebagai anti-Helicobacter pylori." Bioma : Jurnal Ilmiah Biologi 10, no. 2 (October 11, 2021): 217–28. http://dx.doi.org/10.26877/bioma.v10i2.8236.

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Helicobacter pylori diketahui sebagai penyebab utama tukak lambung dengan melemahkan lapisan pelindung pada lambung dan duodenum. Sejumlah obat anti tukak lambung yang sering digunakan dapat menyebabkan resistensi pada H. pylori. Ganoderma lucidum diketahui dapat menghambat dan mendukung penyembuhan tukak lambung yang disebabkan oleh asam asetat. Akan tetapi, kemampuan G. lucidum dalam menghambat tukak lambung yang disebabkan H. pylori belum banyak diungkap. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak G. lucidum dalam menghambat pertumbuhan H. pylori penyebab tukak lambung. Penelitian merupakan ekperimental dua faktorial yaitu jenis pelarut fraksinasi dan konsentrasi ektrak G. lucidum. Ekstrak G. lucidum difraksinasi menggunakan dua jenis pelarut yaitu etanol 60% dan akuades. Konsentrasi ekstrak G. lucidum yang digunakan adalah 1, 5, 10, 20, 30 mg/mL. Efektivitas ekstrak G. lucidum diuji dengan metode difusi cakram. Berdasarkan analisis statistik didapat bahwa jenis pelarut berpengaruh terhadap aktivitas daya hambat H. pylori dengan nilai pada pelarut etanol 60% signifikan lebih tinggi dibandingkan akuades. Konsentrasi ekstrak G. lucidum baik etanol maupun akuades berpengaruh signifikan terhadap aktivitas daya hambat. Aktivitas daya hambat tertinggi adalah pada perlakuan ekstrak etanol G. lucidum konsentrasi 20 mg/ml. Kata kunci: akuades; difusi cakram; etanol; Helicobacter pylori; Ganoderma lucidum ABSTRACTOptimization and effectiveness assay of Ganoderma lucidum extract as Anti-Helicobactor pylori. Helicobacter pylori is known to be the main cause of gastric ulcers by weakening the protective lining of the stomach and duodenal. A number of gastric anti-ulcer drugs can cause resistance to H. pylori. Ganoderma lucidum is known to inhibit and support the healing of gastric ulcers caused by acetic acid. G. lucidum's ability to inhibit H. pylori growth has not been revealed much. This research aims to find out the effectiveness of G. lucidum extract in inhibiting the growth of H. pylori which causes gastric ulcers. This study is an experimental two factorial namely the type of fractionation solvent and the concentration of G. lucidum extract. Ganoderma lucidum extract is diffractionated using two types of solvents namely 60% ethanol and akuades. The concentration of G. lucidum extract used is 1, 5, 10, 20, 30 mg/mL. The effectiveness of G. lucidum is tested using the disc diffusion method. Based on statistical analysis found that the type of solvent affects the activity of H. pylori's resistance with a value in ethanol solvents 60% significantly higher than akuades On the other hand the concentration of G. lucidum extract in both ethanol and aquades has a significant effect on the activity of the slave. The highest inhibitory activity is in the treatment of ethanol extract G. lucidum concentration 20 mg / ml. Keywords: aquades; diffusion disc; ethanol; Helicobacter pylori; Ganoderma lucidum
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Cancemi, Gabriella, Santino Caserta, Sebastiano Gangemi, Giovanni Pioggia, and Alessandro Allegra. "Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer." Journal of Clinical Medicine 13, no. 4 (February 18, 2024): 1153. http://dx.doi.org/10.3390/jcm13041153.

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Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal fungus Ganoderma lucidum. There is evidence of the effects of ganoderic acid in hematological malignancies, whose mechanisms involve the stimulation of immune response, the macrophage-like differentiation, the activation of MAP-K pathway, an IL3-dependent cytotoxic action, the induction of cytoprotective autophagy, and the induction of apoptosis. In fact, this compound has been tested in twenty-six different human cancer cell types and has shown an anti-proliferative activity, especially in leukemia, lymphoma, and myeloma lines. Moreover, research clarified the capability of molecules from Ganoderma lucidum to induce mitochondrial damage in acute promyelocytic leukemia cells, without cytotoxic effects in normal mononuclear cells. Active lipids extracted from the spores of this fungus have also been shown to induce apoptosis mediated by downregulation of P-Akt and upregulation of caspases-3, -8, and -9. Among in vivo studies, a study in BALB/c mice injected with WEHI-3 leukemic cells suggested that treatment with Ganoderma lucidum promotes differentiation of T- and B-cell precursors, phagocytosis by PBMCs, and NK cell activity. Our review presents data revealing the possibility of employing Ganoderma lucidum in hematological malignancies and incorporating it into clinical practice.
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Shieh, Ying-Hua, Chi-Feng Liu, Yao-Kuan Huang, Jen-Yuann Yang, I.-Lin Wu, Chia-Hsien Lin, and Song-Chow Lin. "Evaluation of the Hepatic and Renal-protective Effects of Ganoderma lucidum in Mice." American Journal of Chinese Medicine 29, no. 03n04 (January 2001): 501–7. http://dx.doi.org/10.1142/s0192415x01000526.

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The antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation had been studied. In order to further investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide induced hepatic and renal damages.
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Dissertations / Theses on the topic "Ganoderma lucidum"

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Thakur, A. K. "Study of a lectin from ganoderma lucidum." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2007. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2591.

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Roberts, Lyndal, and lyndalroberts@gmail com. "Australian Ganoderma : identification, growth & antibacterial properties." Swinburne University of Technology. Environment and Biotechnology Centre, 2004. http://adt.lib.swin.edu.au./public/adt-VSWT20060109.114954.

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Ganoderma species are one of the most widely researched fungi because of their reported potent bioactive properties. Although there is much information related to American, European and Asian isolates, little research has been conducted on Australian Ganoderma isolates. Ganoderma may only be imported into Australia under strict quarantine conditions, therefore, the isolation of a native strain that possesses bioactivity may be industrially and commercially significant. Three Australian species of this wood-decomposing fungus were isolated in northern Queensland. In this study, they have been identified as three separate species. Further, they have been studied to determine their optimal growth conditions in liquid culture and assessed for their antibacterial properties. Phylogeny inferred from the Internal Transcribed Spacer Regions (ITS) from the DNA sequences resolved the three Australian Ganoderma species into separate clades. Two isolates were identified to be isolates of Ganoderma cupreum (H1) and Ganoderma weberianum (H2). The third isolate could only be identified to the genus level, Ganoderma species, due to the lack of informative data that could be used for comparison. The effects of short term and long term storage on the viability of the fungi were investigated on agar plates, agar slants and balsa wood at varying temperatures ranging from 10 to 45�C. The most appropriate storage conditions were determined to be �80�C on balsa wood chips for periods of up to 2 years without subculture, and on agar slants at 4�C for up to a maximum of eight weeks. Light was observed to be detrimental to the survival of Ganoderma H1 and Ganoderma H2 during storage. Growth trials using potato dextrose agar plates determined the optimal temperature and pH for mycelial growth to be 30�C and a pH of 6, for all isolates. Subsequent growth trials in liquid media found that glucose, as the carbohydrate source, supported the greatest mycelial growth of Ganoderma H1 and Ganoderma H2 and that galactose and fructose supported the greatest growth of Ganoderma H3. Abstract ii Aqueous (hot water) and organic (hexane (HEX), dichloromethane (DCM), ethyl acetate (EtOAc), methanol (MeOH)) extracts from the liquid cultivated mycelium were assessed for their antibacterial activity using disc diffusion assays. Extracts from the mycelium of Ganoderma H1 exhibited activity against a greater number of Gram positive bacteria than those from Ganoderma H2 and H3. Subsequent studies on the DCM and EtOAc extracts from Ganoderma H1 determined the MIC and MBC against a number of Gram positive bacteria, including Bacillus cereus, B. subtilis, Enterococcus faecalis, Streptococcus pyogenes, Staphylococcus aureus, S. epidermidis and Listeria monocytogenes, as well as Clostridium species, including Clostridium perfringens, C. sporogenes and C. difficile, and some methicillin resistant Staphylococcus aureus (MRSA) strains. Time course growth assays confirmed that the DCM and EtOAc extracts predominantly exhibited bactericidal activity. Finally, the active compounds were determined to be terpenoid in structure with some phenolic groups attached.
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Ho, Yee-wa Eva, and 何綺華. "Effects of Ganoderma lucidum on rheumatoid synovial fibroblasts." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29489933.

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Chan, Sze-yin. "The effects of ganoderma extracts on immune cell subsets." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43781494.

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ADASKAVEG, JAMES ELLIOTT. "STUDIES OF GANODERMA LUCIDUM AND GANODERMA TSUGAE (DELIGNIFICATION, MATING SYSTEMS, ROOT ROT, CULTURAL MORPHOLOGY, TAXONOMY)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/188172.

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Ganoderma lucidum and G. tsugae are two members of the G. lucidum complex. The authenticity of the two wood-rotting species was demonstrated by comparative studies. Ganoderma lucidum is restricted to hardwoods. Its "smooth" walled basidiospores were characterized by narrow, numerous inter-wall pillars. Isolates of G. lucidum produced chlamydospores in culture and had an average growth of 7.8 mm/da at their optimum temperature range of 30-34 C. Ganoderma tsugae is restricted to conifers. Its basidiospores were "rough" walled and had broad inter-wall pillars. Isolates of G. tsugae did not produce chlamydospores in culture and had an average growth of 2.1 mm/da at the optimum temperature range of 20-25 C. Mating systems were determined for both species as heterothallic and tetrapolar. Interspecific matings of homokaryons were incompatible. Homokaryons of a European G. resinaceum isolate were interfertile with homokaryons from North American collections of G. lucidum. The ability of G. lucidum and G. tsugae to decay wood in vitro was studied using the following woods in agar block decay chambers: grape, oak, mesquite, white fir, and Douglas-fir. Grape wood lost the most weight while mesquite the least. G. lucidum isolates generally caused greater weight loss of all woods than did G. tsugae isolates. Both Ganoderma species caused simultaneous decay in all woods. However, chemical analyses of the decayed blocks indicated that selective delignification by both species also occurred in grape and white fir blocks but not in oak or Douglas-fir blocks. Scanning electron microscopy demonstrated various stages of selective delignification and simultaneous decay of all woods tested. Isolates of Ganoderma lucidum infected Dog Ridge variety grape plants, grown in the greenhouse, from below-ground wood block inoculations. Twenty-four plants were inoculated: one plant died and 4 other plants declined. After 24 months reisolations yielded only G. lucidum from the five declining plants, demonstrating pathogenicity. The fungus developed in the heartwood and, in later stages, invaded the sapwood. Infected plants developed water stress symptoms with leaves wilting, yellowing, and dying. Field grape plants inoculated with the fungus developed decay columns as large as 42 cm in 17 mons. Decay was limited to the heartwood; no foliar symptoms occurred.
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Zhao, D. "Novel processing and microencapsulation of Ganoderma lucidum spores for healthcare." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1416860/.

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Ganoderma lucidum spores (GLS) have attracted increasing attention for its versatile biological activities, particularly in cancer therapy. The resilient chitin bilayer of sporoderm is conventionally regarded as an obstacle in the exploitation of bioactive ingredients. Present study found that ethanol extract of broken GLS was able to inhibit cancer cells, however, water extract, especially medium extract (containing serum protein) from unprocessed GLS have also demonstrated anti-proliferative effects on cancer cells. The effectiveness of GLS extract on the inhibition of a series of human cancer cells, namely, osteosarcoma, neuroblastoma, myeloid leukaemia and breast cancer, has been compared, and DNA assays showed that the GLS extract is more efficient in inhibiting neuroblastoma but has less effect on osteosarcoma cell line. To overcome the limitations of the existing processing methods of GLS, the feasibility of sonication as a new way to break GLS has been tested. A series of processing parameters, such as sonication power and duration, have been compared to maximise the breaking efficiency. The preservation of bioactive components of GLS (e.g. polysaccharides and ganoderic acids) from sonication processing was revealed by Fourier Transform Infrared Spectroscopy (FTIR) and High Performance Liquid Chromatography (HPLC) analyses. In vitro study showed that sonication processed GLS were able to inhibit breast cancer cells, at dose and time dependent manner, particularly at low pH (6.5), favourable for cancerous cell growth. The inhibitory efficiency of sonication processed GLS on the growth of breast cancer cells was ranked the highest, compared with that of unprocessed GLS and commercially broken GLS. To preserve further the bioactive ingredients of GLS, broken GLS have been encapsulated with alginate by electrospraying (ES). The size of GLS encapsulated alginate (GLS/A) beads was found to affect the in vitro release profiles of bioactive ingredients of GLS, and can be controlled by varying the processing parameters (e.g. crosslinking time, infuse rates and applied voltage). A series of GLS/A beads with mean sizes ranging from 500 to 2500 µm have been produced by ES and the in vitro release profiles of GLS/A beads in simulated gastrointestinal mediums were found to be related to the pH, bead size and drying methods. In summary, an advanced method combining a customised sonication with ES has been developed by setting up a lab-scale production line from processing to encapsulation of GLS. This may pave the way to produce effective GLS products with desirable natural bioactive components for healthcare.
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Wai, Wing-yin Eric. "Effect of herbal medicine (Ganoderma lucidum) on nitric oxide production in macrophages." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B3197126X.

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Fazenda, Mariana L. "Submerged culture fermentation of the Basidiomycete fungus Ganoderma lucidum for biomass formation." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501792.

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The aim of the present study was to investigate a range of bioprocess strategies aimed at the achievement of maximum biomass yield in submerged cultivation of the Basidiomycete, Ganoderma lucidum. Although there had been previous studies into cultivation of G, lucidum, these had been almost exclusively centred round maximisation of the medically interesting polysaccharide, EPS. The present work is focused on the development of fermentation strategies to achieve this aim, which was a central interest of the sponsor. Additionally, to investigate the process physiology of these complex cultures to help improve the relatively poor, understanding of the bioprocessing of this Basidiomycete fungus and to understand the influence of process variables during submerged cultivation of G. lucidum on growth, polysaccharide production and substrate consumption.
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衛穎賢 and Wing-yin Eric Wai. "Effect of herbal medicine (Ganoderma lucidum) on nitric oxide production in macrophages." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3197126X.

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Viana, Sthefany Rodrigues Fernandes [UNESP]. "Comportamento agronômico e caracterização bioquímica de linhagens de Ganoderma lucidum cultivadas em serragem." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/90675.

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O fungo Ganoderma lucidum (Fr.) Krast, também conhecido como Lingzhi ou Reish, é um basidiomiceto pertencente à família Ganodermataceae, muito estudado por suas características medicinais. Imunomodulação e atividade antitumoral são algumas de suas indicações mais importantes à saúde humana, devem-se principalmente à presença de polissacarídeos e triterpenóides, que há séculos são utilizados na China, Japão e Coréia por fins terapêuticos. Com a crescente demanda por pesquisa com uso de Ganoderma lucidum no tratamento de doenças, a otimização da produção comercial tornou-se necessária para atender as demandas de mercado e de pesquisa. Assim, os objetivos do presente trabalho foram: 1. avaliar e comparar a eficiência biológica e o rendimento de 7 linhagens de G. lucidum, 351, 1002, 0901, 0809, 339, 144, 202, cedidas por produtores e pesquisadores ao banco de linhagens do Módulo de Cogumelos FCA/UNESP. Todas cultivadas em substrato à base de serragem de eucalipto; 2. quantificar as concentrações de β-glucanas, fenólicos totais e proteínas nas linhagens estudadas. O substrato de cultivo foi composto de 80% de material volumoso (serragem de eucalipto) e 20% de farelos (trigo e soja) contendo 620g cada saco de cultivo. A quantificação das β-glucanas foi realizada por método enzimático; para a quantificação de fenólicos totais, utilizou-se o método de Folin-Ciocalteau e para proteínas totais o método utilizado foi de Lowry. O cultivo, desde a inoculação do substrato até a colheita dos basidiomas, durou, em média, 65 dias. Em relação a eficiência biológica as linhagens obedeceram a seguinte ordem 351 ≥ 1002...
The fungus Ganoderma lucidum (Fr.) Krast , also known as Lingzhi or Reish, is a basidiomycete belonging to Ganodermataceae family, widely studied for its medicinal characteristics . Immunomodulation and antitumor activity are some of his most important insights to human health, are mainly due to the presence of polysaccharides and triterpenoids , which are used for centuries in China, Japan and Korea for therapeutic purposes. With the growing demand for research use of Ganoderma lucidum in treating diseases , optimization of commercial production became necessary to meet market demands and research . The objectives of this study were: 1 . evaluate and 4 compare the biological efficiency and yield of 7 strains of Ganoderma lucidum , 351 , 1002, 0901 , 0809 , 339 , 144 , 202 , assigned by producers and researchers to bank lines Module Mushrooms FCA / UNESP . All grown on substrate with sawdust ; 2 . quantify the concentrations of β - glucan , total phenolics and proteins in the strains studied . The culture substrate was composed of 80 % of bulk material ( sawdust ) and 20% bran (wheat and soybeans ) containing 620g each bag cultivation . Quantification of β - glucans was performed by enzymatic method ; for quantification of total phenolic used the Folin -Ciocalteau total protein and the Lowry method was used . The cultivation , from inoculation to harvest the substrate of the mushroom lasted , on average, 65 days. Relative biological effectiveness strains obeyed the following order 351 ≥ 1002 ≥ 0901 = 0809 = 339 with 15.00% , 13.10 % , 11.77 % , 11.29 % and 10.87 % . The yield followed the same order of significance , and obtained the following values : 5.95, 4.98 , 4.31 , 4.29 , and 4.18 g kg - 1 strains respectively. The line with the highest concentration of β - glucans was 1002 with 10.50 g/100 g of dry mushroom. The strains with the highest concentration of total phenolics were 1002 and 08 ...
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Books on the topic "Ganoderma lucidum"

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Pagunsan, Levi H. Ganoderma for optimum health and longevity. [United States: s.n.], 2004.

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Feng, Guorong. Quan mian ren shi ling zhi yun zhi. Xianggang: Jing ji ri bao chu ban she, 2005.

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Fritz, Vanessa. Lingzhi (Ganoderma lucidum) and Dongchongxiacao (Cordyceps spp.): Applications in the treatment of cancer. Portland, Or: NCNM, 2007.

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Long, Er. Ling zhi. Xianggang: Wan li ji gou, De li shu ju, 2011.

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Hseu, Ruey-Shyang. Ling zhi shu jun zhu jian ding xi tong zhi yan jiu: An identification system for cultures of Ganoderma species. 1990.

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Ortiz, Petra, and Mentol. Ganoderma Lucidum Testimonials: A Lined Journal for Personal Testimonies. Independently Published, 2020.

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What Is Healthy Coffee and How Does Ganoderma Lucidum in My Coffee Make It Healthier: Large Print and Black and White Images. Learn How Ganoderma Lucidum in Coffee, Green Tea and Hot Chocolate Can Help Anyone. CreateSpace Independent Publishing Platform, 2012.

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Solid-State Cultivation of Grifola Frondosa and Ganoderma Lucidum: Technology, Research and Possibilities for Waste Utilization in Tropical Weathers. Nova Science Publishers, Incorporated, 2019.

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Montoya, Sandra, Oscar J. Sanchez, and Diego F. Arias. Solid-State Cultivation of Grifola Frondosa and Ganoderma Lucidum: Technology, Research and Possibilities for Waste Utilization in Tropical Weathers. Nova Science Publishers, Incorporated, 2020.

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Book chapters on the topic "Ganoderma lucidum"

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Bährle-Rapp, Marina. "Ganoderma Lucidum Extract." In Springer Lexikon Kosmetik und Körperpflege, 217. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_4164.

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Majumdar, Sayari, and Pradeep Singh Negi. "Recent Updates on Antiviral Efficacy of Ganoderma lucidum." In Ganoderma, 49–63. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003490258-3.

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Dong, Caixia, and Quanbin Han. "Ganoderma lucidum 灵芝 (Lingzhi, Ganoderma)." In Dietary Chinese Herbs, 759–66. Vienna: Springer Vienna, 2015. http://dx.doi.org/10.1007/978-3-211-99448-1_85.

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Ajith, Thekkuttuparambil A., and Kainoor K. Janardhanan. "Hepatoprotective Effect of Ganoderma lucidum (Curt.:Fr.) P. Karst." In Ganoderma, 86–91. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003354789-5.

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Bhakshu, Lepakshi, KV Ratnam, Pulala Raghuveer Yadav, C. Meera Saheb, Anu Pandita, and Deepu Pandita. "Reishi Mushroom (Ganoderma lucidum)." In Mushrooms, 170–90. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003322238-11.

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Owaid, Mustafa Nadhim. "Ganoderma lucidum: King of Mushroom." In Non-Timber Forest Products, 325–37. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73077-2_14.

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Tomlinson, Brian, Sze Wa Chan, and Paul Chan. "Lingzhi (Ganoderma lucidum) and Cardiovascular Disease." In Ancient and Traditional Foods, Plants, Herbs and Spices used in Cardiovascular Health and Disease, 247–57. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003220329-18.

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Su, Zheng-Yuan, and Lee-Yan Sheen. "An Evidence-based Perspective of Ganoderma Lucidum (Lucid Ganoderma) for Cancer Patients." In Evidence-based Anticancer Materia Medica, 245–63. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0526-5_12.

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Wei, Zhen-Hua, and Jian-Jiang Zhong. "Production of Ganoderma lucidum Polysaccharides by Fermentation." In Functional Carbohydrates, 219–56. Boca Raton : CRC Press, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371061-7.

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Gafforov, Yusufjon, Aisha Umar, Soumya Ghosh, Michal Tomšovský, Mustafa Yamaç, Milena Rašeta, Manzura Yarasheva, Wan Abd Al Qadr Imad Wan-Mohtar, and Sylvie Rapior. "Ganoderma adspersum (Schulzer) Donk; Ganoderma applanatum (Pers.) Pat.; Ganoderma lucidum (Curtis) P. Karst.; Ganoderma resinaceum Boud. - GANODERMATACEAE." In Ethnobiology of Uzbekistan, 1135–69. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23031-8_111.

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Conference papers on the topic "Ganoderma lucidum"

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Lyamtseva, A. K., and T. R. Romanovskaya. "INFLUENCE OF THE GANODERMA LUCIDUM FRUIT BODIES EXTRACT ON INNATE IMMUNITY INDICATORS IN THE MODEL OF AN IMMUNE RESPONSE IN BALB/C MICE." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-62-65.

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Modern laboratory and clinical studies have revealed antitumor, immunomodulatory, hepatoprotective, antioxidant, and other properties of Ganoderma lucidum due to the presence in its composition of individual components with pharmacological activity. Its effects on the immune system are varied. The main immunotropic effect of the Ganoderma lucidum fruit bodies extract is aimed at increasing the indicators of the phagocytic activity of peritoneal macrophages and increasing the activity of the classical pathway of activation of the complement system.
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Kien, Pham Van, Doan Thanh Son, and Nguyen Quang Sang. "Study of thermophysical properties of Ganoderma lucidum." In 1ST VAN LANG INTERNATIONAL CONFERENCE ON HERITAGE AND TECHNOLOGY CONFERENCE PROCEEDING, 2021: VanLang-HeriTech, 2021. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0066892.

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Tritean, Naomi, Ștefan-Ovidiu Dima, Anisoara Cimpean, Diana Constantinescu-Aruxandei, and Florin Oancea. "Optimized Extraction of Glycoproteins from Ganoderma lucidum." In Priochem 2021. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/chemproc2022007053.

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Гасина, М. И. "Биоэкологические особенности вида Ganoderma lucidum (Curtis) P. Karst." In III молодёжная всероссийская научная конференция с международным участием «PLANTAE & FUNGI». Botanical Garden-Institute FEB RAS, 2023. http://dx.doi.org/10.17581/paf2023.49.

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В ходе анализа гербарных образцов Ganoderma lucidum (Curtis) P. Karst было выявлено, что данный вид часто определяется ошибочно. При этом характеристика природных изолятов слишком ограничена описанием морфологии базидиом и вегетативной стадии. В связи с недостаточностью информации, касающейся данного вида, а также отличительных свойств экземпляров, произрастающих на разных территориях, необходимо проводить более глубокие исследования. Впервые проведён анализ штаммов Ganoderma lucidum Ростовской области на основе морфологических, генетических, биохимических и молекулярных признаков. Плодовые тела данного вида от 3 до 10 см диаметре, жёсткие, округлые, почковидные или вееровидные с боковой или центральной ножкой. Поверхность мягко изгибается, внешне гладкая, волнистая, имеется множество концентрических колец роста разных оттенков. Сердцевина на срезе бело-охряная. Мякоть деревянистая, без вкуса и запаха. Поры беловатые, желтеют с возрастом, приобретают бурую окраску. Ножка 3-10 см длиной и 1-2,5 см толщиной, цилиндрическая, твёрдая, явно красно-коричневая и также лакированная. Как раз присутствие такой особенной ножки у данного вида является главным отличительным признаком [1]. Гриб произрастал только в комлевой части Quercus robur L., встречался редко. В результате макроморфологического анализа и анализа скорости роста штаммов было выявлено, что они относятся к III типу колоний. Для определения использовалась классификация Р. Сталперса [2]. Характеристика колонии: зональная с концентрическими кругами, основной цвет светло-коричневый, реверзум тёмно-коричневый, рост довольно медленный (8 мм в сутки). При микроскопическом анализе наблюдали регулярные пряжки, хламидоспоры, димитическую гифальную систему. Также были подобраны оптимальные условия для роста штаммов. Так, для G. lucidum самая благоприятная температура 25°С, при этом должна поддерживаться высокая влажность.
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Shu Ming Huang, Xin Lin Yang, and He Sun Zhu. "Antitumor effects of triterpene acids extracted from Ganoderma lucidum." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5966079.

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Feng, Zhao-Rui, Huan-Jun Li, and Jun-Wei Xu. "Ganoderic Acid Accumulation and Biosynthetic Gene Expression during Fruiting Body Development in Ganoderma lucidum." In 2015 Asia-Pacific Energy Equipment Engineering Research Conference. Paris, France: Atlantis Press, 2015. http://dx.doi.org/10.2991/ap3er-15.2015.83.

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"In vitro Effects of Ganoderma lucidum Extract on Breast Cancer Cells." In International Conference on Chemical, Environment & Biological Sciences. International Institute of Chemical, Biological & Environmental Engineering, 2014. http://dx.doi.org/10.15242/iicbe.c914126.

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Kien, Pham Van, Doan Thanh Son, and Nguyen Quang Sang. "The optimization of radiofrequency assisted heat pump drying of Ganoderma lucidum." In 1ST VAN LANG INTERNATIONAL CONFERENCE ON HERITAGE AND TECHNOLOGY CONFERENCE PROCEEDING, 2021: VanLang-HeriTech, 2021. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0066669.

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Shuming Huang, Jie Zhang, Min Zhang, Shouguo Shen, Xiaoyan Yin, Xiaoyan Shui, and Dayan Wang. "Study on biotransformation of inorganic selenium from Ganoderma lucidum and yeasts." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5966007.

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Sadiq, Shadman Tariq, and Sara Qahtan Sulaiman. "Green Biosynthesis of Silver Nanoparticles from Wild Mushroom (Ganoderma lucidum) First Time in Iraq." In 7th International Students Science Congress. Izmir International guest Students Association, 2023. http://dx.doi.org/10.52460/issc.2023.054.

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Nowadays there is an increasing interests about nanoparticle due to its application in medical and industrial products, green rout and safely producing of nanoparticles consider important for recent life technology, silver nanoparticles (AgNPs) one of the most safe compound to human and environment due to its low effect an low toxicity even with direct contacting and consuming release low particles of silver, for these reasons , the availability and low costing technology we produced silver nanoparticles from eco-friendly mushroom G. lucidum first time in Iraq. AgNPs were prepared by using aqueous extract of G. lucidium as a reducing agent for silver nitrate (AgNO3). The characteristics of silver- anoparticles were determined, including: Determining the highest absorption of silver nanoparticles by UV-VIS spectrophotometer, the shape and size of silver nanoparticles by atomic force microscopy (AFM), as well as determining the type of chemical bonds or functional groups bound to the prepared AgNPs by Fourier-transform infrared spectroscopy-FTIR. Scanning Electron Microscopy used for study of Particle size and shape. The results showed the emergence of a spectral imaging beam using a spectrophotometer that ranged between 350-900 nm, where the best absorption beam was at a wavelength of 450 nm, while the result of AFM showed the surface topography of silver nanoparticles with an average size of 62.78 nm. FTIR spectrum revealed strong absorption peaks 1091-3434 cm-1, as well as their role in the stability of these molecules. The size of spherical particles ranged between 17.15 - 25.81 nanometers under SEM.
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Reports on the topic "Ganoderma lucidum"

1

C.A.Reddy, PI. Structure and Biochemestry of Laccases from the Lignin-Degrading Basidiomycete, Ganoderma lucidum. Office of Scientific and Technical Information (OSTI), June 2005. http://dx.doi.org/10.2172/883001.

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Qin, Li-hong, Chen Wang, Xiao-xue Jiang, You Song, Yao Feng, Li-wei Qin, and Shu-ping Zhang. Effects of Spore Powder of Ganoderma Lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: a protocol of systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0041.

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