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Author: Grafiati

Published: 10 December 2022

Last updated: 21 February 2023

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1

Mann, Nina, Slim Mzoughi, Ronen Schneider, Susanne J. Kühl, Denny Schanze, Verena Klämbt, Svjetlana Lovric, et al. "Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome." Journal of the American Society of Nephrology 32, no. 3 (February 16, 2021): 580–96. http://dx.doi.org/10.1681/asn.2020040490.

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BackgroundGalloway-Mowat syndrome (GAMOS) is characterized by neurodevelopmental defects and a progressive nephropathy, which typically manifests as steroid-resistant nephrotic syndrome. The prognosis of GAMOS is poor, and the majority of children progress to renal failure. The discovery of monogenic causes of GAMOS has uncovered molecular pathways involved in the pathogenesis of disease.MethodsHomozygosity mapping, whole-exome sequencing, and linkage analysis were used to identify mutations in four families with a GAMOS-like phenotype, and high-throughput PCR technology was applied to 91 individuals with GAMOS and 816 individuals with isolated nephrotic syndrome. In vitro and in vivo studies determined the functional significance of the mutations identified.ResultsThree biallelic variants of the transcriptional regulator PRDM15 were detected in six families with proteinuric kidney disease. Four families with a variant in the protein’s zinc-finger (ZNF) domain have additional GAMOS-like features, including brain anomalies, cardiac defects, and skeletal defects. All variants destabilize the PRDM15 protein, and the ZNF variant additionally interferes with transcriptional activation. Morpholino oligonucleotide-mediated knockdown of Prdm15 in Xenopus embryos disrupted pronephric development. Human wild-type PRDM15 RNA rescued the disruption, but the three PRDM15 variants did not. Finally, CRISPR-mediated knockout of PRDM15 in human podocytes led to dysregulation of several renal developmental genes.ConclusionsVariants in PRDM15 can cause either isolated nephrotic syndrome or a GAMOS-type syndrome on an allelic basis. PRDM15 regulates multiple developmental kidney genes, and is likely to play an essential role in renal development in humans.

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Rosti, Rasim Ozgur, Bethany N. Sotak, Stephanie L. Bielas, Gifty Bhat, Jennifer L. Silhavy, Ayca Dilruba Aslanger, Umut Altunoglu, et al. "Homozygous mutation inNUP107leads to microcephaly with steroid-resistant nephrotic condition similar to Galloway-Mowat syndrome." Journal of Medical Genetics 54, no. 6 (March 9, 2017): 399–403. http://dx.doi.org/10.1136/jmedgenet-2016-104237.

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BackgroundMicrocephaly with nephrotic syndrome is a rare co-occurrence, constituting the Galloway-Mowat syndrome (GAMOS), caused by mutations inWDR73(OMIM: 616144). However, not all patients harbour demonstrableWDR73deleterious variants, suggesting that there are other yet unidentified factors contributing to GAMOS aetiology.MethodsAutozygosity mapping and candidate analysis was used to identify deleterious variants in consanguineous families. Analysis of patient fibroblasts was used to study splicing and alterations in cellular function.ResultsIn two consanguineous families with five affected individuals from Turkey with a GAMOS-like presentation, we identified a shared homozygous variant leading to partial exon 4 skipping innucleoporin, 107-KD(NUP107). The founder mutation was associated with concomitant reduction in NUP107 protein and in the obligate binding partner NUP133 protein, as well as density of nuclear pores in patient cells.ConclusionRecently,NUP107was suggested as a candidate in a family with nephrotic syndrome and developmental delay. OtherNUP107-reported cases had isolated renal phenotypes. With the addition of these individuals, we implicate an allele-specific critical role forNUP107in the regulation of brain growth and a GAMOS-like presentation.

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3

Halleran, Michael R. "Gamos and Destruction in Euripides' Hippolytus." Transactions of the American Philological Association (1974-) 121 (1991): 109. http://dx.doi.org/10.2307/284446.

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4

Schneider, Diane. "Gamos et Thanatos : le sacrifice virginal dans la tragédie grecque / Gamos and Thanatos: Virginal Sacrifice in Greek Tragedy." ASDIWAL. Revue genevoise d'anthropologie et d'histoire des religions 6, no. 1 (2011): 182–88. http://dx.doi.org/10.3406/asdi.2011.967.

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5

Ross, Arra Lynn. "Heiros Gamos, and: A Means of Approach to Ecstasy." Prairie Schooner 85, no. 2 (2011): 119–22. http://dx.doi.org/10.1353/psg.2011.0061.

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6

Harkness, L. J., P. Arce, D. S. Judson, A. J. Boston, H. C. Boston, J. R. Cresswell, J. Dormand, et al. "A Compton camera application for the GAMOS GEANT4-based framework." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 671 (April 2012): 29–39. http://dx.doi.org/10.1016/j.nima.2011.12.058.

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7

Li, Hongyan, Fang Liu, Hanzhe Kuang, Hua Teng, Siyi Chen, Sijing Zeng, Qimin Zhou, et al. "WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway–Mowat Syndrome." Biology 11, no. 10 (September 25, 2022): 1397. http://dx.doi.org/10.3390/biology11101397.

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(1) Background: Galloway–Mowat syndrome (GAMOS) is a rare genetic disease, classically characterized by a combination of various neurological symptoms and nephrotic syndrome. WDR73 is the pathogenic gene responsible for GAMOS1. However, the pathological and molecular mechanisms of GAMOS1, especially nephrotic syndrome caused by WDR73 deficiency, remain unknown. (2) Methods and Results: In this study, we first observed remarkable cellular morphological changes including impaired cell adhesion, decreased pseudopodia, and G2/M phase arrest in WDR73 knockout (KO) HEK 293 cells. The differentially expressed genes in WDR73 KO cells were enriched in the focal adhesion (FA) pathway. Additionally, PIP4K2C, a phospholipid kinase also involved in the FA pathway, was subsequently validated to interact with WDR73 via protein microarray and GST pulldown. WDR73 regulates PIP4K2C protein stability through the autophagy–lysosomal pathway. The stability of PIP4K2C was significantly disrupted by WDR73 KO, leading to a remarkable reduction in PIP2 and thus weakening the FA formation. In addition, we found that podocyte-specific conditional knockout (Wdr73 CKO) mice showed high levels of albuminuria and podocyte foot process injury in the ADR-induced model. FA formation was impaired in primary podocytes derived from Wdr73 CKO mice. (3) Conclusions: Since FA has been well known for its critical roles in maintaining podocyte structures and function, our study indicated that nephrotic syndrome in GAMOS1 is associated with disruption of FA caused by WDR73 deficiency.

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8

Liviabella Furiani, Patrizia. "Gamos e kenogamion nel romanzo di Achille Tazio." Euphrosyne 16 (January 1988): 271–80. http://dx.doi.org/10.1484/j.euphr.5.126616.

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9

Arce, Pedro, Juan Ignacio Lagares, and Diego Azcona. "A utility to read automatically DICOM format data for GAMOS/Geant4 simulation." Physica Medica 32 (September 2016): 256. http://dx.doi.org/10.1016/j.ejmp.2016.07.549.

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10

Amato, Ernesto, Lucrezia Auditore, Antonio Italiano, Daniele Pistone, Pedro Arce, Alfredo Campennì, and Sergio Baldari. "Full Monte Carlo internal dosimetry in nuclear medicine by means of GAMOS." Journal of Physics: Conference Series 1561 (June 2020): 012002. http://dx.doi.org/10.1088/1742-6596/1561/1/012002.

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11

Auditore, Lucrezia, Ernesto Amato, Antonio Italiano, Pedro Arce, Alfredo Campennì, and Sergio Baldari. "Internal dosimetry for TARE therapies by means of GAMOS Monte Carlo simulations." Physica Medica 64 (August 2019): 245–51. http://dx.doi.org/10.1016/j.ejmp.2019.07.024.

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12

Cañadas, M., P. Arce, and P. Rato Mendes. "Validation of a small-animal PET simulation using GAMOS: a GEANT4-based framework." Physics in Medicine and Biology 56, no. 1 (December 9, 2010): 273–88. http://dx.doi.org/10.1088/0031-9155/56/1/016.

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13

Poeta, P., T. Antunes, and J. Rodrigues. "Enterococcus spp. resistentes à vancomicina isolados de fezes de frangos, pombos, gamos e ratos." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 57, no. 3 (June 2005): 412–14. http://dx.doi.org/10.1590/s0102-09352005000300023.

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14

Thảo, Nguyễn Thị Phương, and Trương Trường Sơn. "Sử dụng phần mềm gamos để tính liều trong điều trị ung thư gan." Tạp chí Khoa học 16, no. 6 (September 25, 2019): 92. http://dx.doi.org/10.54607/hcmue.js.16.6.2515(2019).

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Với giả sử sự phân bố thuốc phóng xạ Y-90 trong gan là đồng nhất, các giá trị S được tính toán cho gan và một số vùng cơ quan, áp dụng cho phantom voxel ICRP nam và nữ, thực hiện bởi phần mềm GAMOS, được tính toán dựa trên code Geant4. Sau đó, thực hiện việc so sánh giá trị S tự chiếu cho gan của phantom voxel ICRP và phantom hình học tính bởi phần mềm OLINDA/EXM. Cuối cùng, giá trị S được hiệu chỉnh cho người Việt Nam và các nước châu Á dựa trên khối lượng gan trung bình theo thông số khảo sát của IAEA. Kết quả cho thấy có sự khác biệt lớn trong việc tính các giá trị S cho các đối tượng khác nhau. Sai khác lớn nhất xảy ra với người Ấn Độ (trên 60%). Với người Việt Nam, sai khác trên 30%. Từ đó cho thấy cần phải tính liều riêng biệt cho từng đối tượng bệnh nhân cụ thể.

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15

Gottesman, A. "The Authority of Telemachus." Classical Antiquity 33, no. 1 (April 1, 2014): 31–60. http://dx.doi.org/10.1525/ca.2014.33.1.31.

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The role of Telemachus in the Odyssey is a perennial puzzle. This paper argues that Telemachus must reconstruct authority in Ithaca in order to present the death of the suitors as a lawful execution rather than as an extra-legal murder. This is part of the Odyssey's strategy to exonerate Odysseus from any possible blame. The job falls to Telemachus because in the Odyssey authority is premised on personal relationships, and the suitors simply do not know Odysseus. The construction of authority occurs in a sympotic and domestic arena where Telemachus competes against the suitors to assert control over the key social practices of marriage (gamos), transportation (pompê), and hospitality (xeinia).

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16

Berggren, Kristina. "Spindle Whorls: their Symbolism in the Villanovan Cemetery of Quattro Fontanili, Veii." Current Swedish Archaeology 1, no. 1 (December 28, 1993): 7–24. http://dx.doi.org/10.37718/csa.1993.01.

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The hypothesis presented in this paper is that the apparently insignificant pottery spindle whorl is a symbol of transformation of death into new life by analogy with mankind's oldest abstract image, the circle, and with the important inventions of pottery making and spinning. This funerary symbolism, which earlier was dominated by the feminine principle, in the Villanovan culture receives the male figure. The Villanovan culture, in Central Italy, is a transition between the old, inward-looking, immobile village and the new expanding Etruscan city-state. During this transition the spindle whorl begins, as an abstract image, to symbolize the feminine principle in the hieros gamos, later represented as the intercourse between the goddess and the god.

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17

Abdalaoui Slimani, Faical Alaoui, and M’hamed Bentourkia. "Abstract ID: 103 GAMOS: Implementation of a graphical user interface for dosimetry calculation in radiotherapy." Physica Medica 45 (January 2018): S1—S2. http://dx.doi.org/10.1016/j.ejmp.2017.11.025.

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18

Al Zain, Jamal, T. El Bardouni, Maged Mohammed, and O. El Hajjaji. "Validation of GAMOS code based on Geant4 Monte Carlo for a 12 MV Saturne43 Linac." Journal of King Saud University - Science 31, no. 4 (October 2019): 500–505. http://dx.doi.org/10.1016/j.jksus.2018.07.003.

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19

Arce, P., N. T. P. Thao, N. T. Trung, D. Azcona, and P. B. Aguilar-Redondo. "Precise dose calculations in nuclear medicine dosimetry using a graphical user interface based on GAMOS/GEANT4." Physica Medica 92 (December 2021): S32—S33. http://dx.doi.org/10.1016/s1120-1797(22)00074-6.

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20

Arce, Pedro, Juan Ignacio Lagares, Laura Harkness, Daniel Pérez-Astudillo, Mario Cañadas, Pedro Rato, María de Prado, et al. "Gamos: A framework to do Geant4 simulations in different physics fields with an user-friendly interface." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 735 (January 2014): 304–13. http://dx.doi.org/10.1016/j.nima.2013.09.036.

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21

Fürst, Isidora. "Položaj žene antičke Grčke u bračnom i porodičnom pravu." Vesnik pravne istorije 1, no. 1/2020 (February 3, 2021): 34–65. http://dx.doi.org/10.51204/hlh_20102a.

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Pravni položaj žene u antičkoj Grčkoj razlikovao se zbog neujednačenosti državnog i društvenog uređenja polisa. U okvirima patrijarhalne društvene organizacije starog veka, položaj žene u društvu i porodici antičke Grčke kretao se od njene potpune obespravljenosti do delimične ravnopravnosti sa muškarcem. Predmet rada su pitanja koja se odnose na karakteristike pravnog statusa žene u porodici (oikos) i braku (gamos), uz analizu uslova koji su uticali na stvaranje i održavanje takve specifične pravno-socijalne tvorevine. U radu se analizira institut miraza i delikt preljube. Autor pruža komparativni prikaz porodičnih i bračnih instituta u tri polisa: Atini, Sparti i Gortini. Postavlja se pitanje da li formalno bolji pravni položaj nužno upućuje na jednako povoljan društveni status. U zaključku rada daje se ocena pravnog statusa žene u staroj Grčkoj, posmatranog iz perspektive patrijarhalnog i klasnog uređenja toga doba, a u skladu sa shvatanjem grčkog duha.

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22

Abdulmalek Rajkhan, Abdulmalek Rajkhan. "GAMOS DICOM Simulation on Occupational EL Dose due to 99mTc and 131I Exposures in Nuclear Medicine Departments." journal of King Abdulaziz University Engineering Sciences 30, no. 1 (February 4, 2019): 65–78. http://dx.doi.org/10.4197/eng.30-1.5.

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Radiation induced cataracts is a disease that is common amongst radiation exposed staff. About 30 percent of retired occupational radiation workers developed eye lens (EL) cataracts. Epidemiological studies on radiation therapy patients, occupational workers, and atomic bomb survivors show that 0.5 Gy of acute or fractioned radiation dose to EL causes one or both lens to cloud. The annual EL dose limit drawn by the International Commission for Radiation Protection (ICRP) was 150 mSv and was changed in 2012 to 20 mSv averaged over 5 years, with no single year exceeding 50 mSv. The limited number of researche done in Nuclear Medicine (NM) clinics with the Hp(3) dosimeters suggest that the annual EL dose from three procedures is measured to be between 4.5 and 9 mSv (i.e. dispensing, preparing and administering). These procedures are performed when the radioactive materials are in closed shielded containers or behind a barrier. Common radioactive material handled by occupational workers in NM clinics are 99mTc and 131I. They pose less radiation hazard to workers EL in the three procedures when they are behind shielded containers. Moreover, once the radioactive material is administered into patients, they become open sources and pose more radiation hazard to workers. The Hp(3) dosimeter is a new uncommon dosimeter. Many radiation facilities use the Hp(0.07) and Hp(10) dosimeters coupled with many conditions and conversion factors to find approximate results. Therefore, simulations are performed to find the EL dose. However, some simulations are performed with little flexibility in simulation geometry, others utilize low-quality phantoms or present the simulation results in terms of fluxes or energy ranges. In the present study, the NM worker EL dose is simulated by utilizing a high-resolution Digital Imagning Communication in Medicine (DICOM) image in GEANT4 Archeticture for Medical Oriented Simulation (GAMOS). A water cylinder homogenously filled by radioactive material, representing the administered patient, was created in the simulation. The worker exposure scenario was simulated by placing the cylinder in three different directions and five different distances with respect to the DICOM image. The results of the simulation reveal that the highest occupational EL radiation dose is received from the anterior-posterior direction, followed by the lateral, and the posterior-anterior directions. The results of the conservative simulated scenario reveal that the worker EL dose is exposed to three tenths of the annual dose limit after 110 131I patients, or 300 99mTc patients.

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Lagares, J. I., P. Arce, J. A. Terrón, J. J. Nieto-Camero, F. Sansaloni, A. Korf, M. T. Romero Expósito, et al. "1428 poster VERIFICATION OF A PROTON THERAPY FACILITY MONTE CARLO SIMULATION BASED ON THE GAMOS/GEANT4 FRAMEWORK." Radiotherapy and Oncology 99 (May 2011): S531. http://dx.doi.org/10.1016/s0167-8140(11)71550-x.

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24

Assalmi, Mustapha, and El Yamani Diaf. "Optimization Techniques and Parameters Setting of the GAMOS Code in the Monte Carlo Simulation of a Medical Accelerator." Moscow University Physics Bulletin 77, no. 3 (June 2022): 511–23. http://dx.doi.org/10.3103/s0027134922030031.

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25

Glaser, Adam K., Stephen C. Kanick, Rongxiao Zhang, Pedro Arce, and Brian W. Pogue. "A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media." Biomedical Optics Express 4, no. 5 (April 17, 2013): 741. http://dx.doi.org/10.1364/boe.4.000741.

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Akçay, D., F. Akman, Z. Karagüler, and K. Akgüngör. "PO-0825: Effect of prosthetic implants on Collapsed Cone algorithm comparison with GAMOS Monte Carlo and film dosimetry." Radiotherapy and Oncology 111 (2014): S70. http://dx.doi.org/10.1016/s0167-8140(15)30943-9.

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Karaoglu, Ayse, Pedro Arce, Diego Obradors, Juan I. Lagares, and Perihan Unak. "Calculation by GAMOS/Geant4 simulation of cellular energy distributions from alpha and lithium-7 particles created by BNCT." Applied Radiation and Isotopes 132 (February 2018): 206–11. http://dx.doi.org/10.1016/j.apradiso.2017.11.021.

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Dubois, Pedro Arce, Nguyen Thi Phuong Thao, Nguyen Thien Trung, Juan Diego Azcona, and Pedro-Borja Aguilar-Redondo. "A tool for precise calculation of organ doses in voxelised geometries using GAMOS/Geant4 with a graphical user interface." Polish Journal of Medical Physics and Engineering 27, no. 1 (March 1, 2021): 31–40. http://dx.doi.org/10.2478/pjmpe-2021-0005.

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Abstract Introduction: The limit of the method of calculating organ doses using voxelised phantoms with a Monte Carlo simulation code is that dose calculation errors in the boundaries of the organs are especially relevant for thin, small or complex geometries. In this report, we describe a tool that helps overcome this problem, accurately calculating organ doses by applying the “parallel geometry” utility feature of Geant4 through the GAMOS framework. Methods and methods: We have tried to simplify the use of this tool by automatically processing the different DICOM image modalities (CT, PT, ST, NM), and by including the automatic conversion of the structures found in a DICOM RTSTRUCT file into Geant4 volumes that build the parallel geometry. For Nuclear Medicine applications, the DICOM PT, ST or NM images are converted into probabilities of generation of primary particles in each voxel, and the DICOM CT images into materials and material densities. For radiotherapy treatments, the DICOM RTPlan or RTIonPlan may also be used, hence the user only needs to describe the accelerator geometry. We also provide a Graphical User Interface for ease of use by for inexperienced users in Monte Carlo. Results: We have tested the functionality of the tool with an I-131 thyroid cancer treatment, and obtained the expected energy deposition and dose differences, given that the particle source, geometry and structures are defined. Conclusions: In summary, we provide an easy-to-use tool to calculate, with high accuracy, organ doses, taking into account their exact geometry as painted by the medical personnel on a voxelised phantom.

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Akcay, D., R. Kandemir, and O. Azaklıoglu. "EP-1503: Small field output correction factors for 6-X and 6-X FFF beams: GAMOS Monte-Carlo study." Radiotherapy and Oncology 119 (April 2016): S694—S695. http://dx.doi.org/10.1016/s0167-8140(16)32753-0.

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30

Franklin, John Curtis. "Lyre Gods of the Bronze Age Musical Koine." Journal of Ancient Near Eastern Religions 6, no. 1 (2006): 39–70. http://dx.doi.org/10.1163/156921206780602636.

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AbstractThat the Late Bronze Age cultural koine included a musical dimension is suggested by the Mesopotamian and Hurrian/Ugaritic musical tablets. This paper presents a selective survey and analysis of evidence for a parallel phenomenon, the deification of lyres/harps, which seemingly originated in late third millennium Mesopotamia and spread abroad in the second. Deified lyres are considered as both a ritual reality and an inducement to poetic elaboration by the same poetpriests who used them; much of the textual evidence thus represents remnants of a professional repertoire. At the same time, the motif also commonly centers on kingship, which is explained in terms of the dual office of priest-kingship; as such, there is some involvement of the deified lyre with the ritual of sacred marriage (hieros gamos). Relevant material comes from Ugarit and Cyprus, especially in the figure of Kinyras. In Greek evidence, 'lyre heroes' like Orpheus, Amphion, Cadmus and Linus are seen as late mythological derivatives of the pattern, Archaic survivals of Mycenaean ritual-poetics. Finally, Old Testament evidence for musical prophecy is considered in light of the foregoing.

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Thao, Nguyen Thi Phuong, Nguyen Thien Trung, and Nguyen Dong Son. "Calculating equivalent dose received from a patient undergoing nuclear medicine procedure by merge phantoms tool and GAMOS/Geant4 6.0.0 software." Physica Medica 68 (December 2019): 41–46. http://dx.doi.org/10.1016/j.ejmp.2019.11.004.

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Al-Tuweity, Jawaher, Younes Sadiq, Amine Mouktafi, Pedro Arce, Imane Fathi, Maged Mohammed, Mohamed Azougagh, El Mehdi Alibrahmi, Hamid Boukhal, and El Mahjoub Chakir. "GAMOS/GEANT4 simulation and comparison study of X-ray narrow-spectrum series at the national Secondary Standard Dosimetry Laboratory of Morocco." Applied Radiation and Isotopes 175 (September 2021): 109789. http://dx.doi.org/10.1016/j.apradiso.2021.109789.

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Pistone, D., A. Campennì, A. Italiano, L. Auditore, E. Amato, and S. Baldari. "Internal dosimetry Monte Carlo study of TARE treatments: a comparison between GATE and GAMOS focused on lung dosimetry and background correction." Physica Medica 92 (December 2021): S127. http://dx.doi.org/10.1016/s1120-1797(22)00271-x.

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Charalampous, Eleni, and Tim Rowland. "The experience of security in mathematics." PNA. Revista de Investigación en Didáctica de la Matemática 7, no. 4 (June 1, 2013): 145–54. http://dx.doi.org/10.30827/pna.v7i4.6123.

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In this paper, we report some findings from an investigation of a topic related to affect and mathematics which is not well-represented in the literature. For some mathematicians, mathematics itself is a source of security in an uncertain world, and we investigated this feeling and experience in the case of 19 adult mathematicians working in universities and schools in Greece. The focus reported here is on ways that a relationship with mathematics offers a sense of permanence and stability on the one hand, and an assurance of novelty and progress on the other.La experiencia de la seguridad en matemáticasEn este trabajo presentamos algunos resultados de una investigación sobre un tema relacionado con el afecto y las matemáticas que no está bien repre-sentado en la literatura. Para algunos matemáticos, las matemáticas en sí mismas son una fuente de seguridad en un mundo incierto; nosotros investi-gamos este sentimiento y experiencia en el caso de 19 matemáticos adultos que trabajan en universidades y escuelas de Grecia. El foco de este artículo es en las maneras en que una relación con las matemáticas ofrece un sentido de permanencia y estabilidad por una parte, y garantía de novedad y progreso, por otra.Handle: http://hdl.handle.net/10481/24790

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Kovárník, Jaromír. "Can similarities be found in the cults of prehistoric hunters and farmers? Analysis of ‘dance’ scenes of four beings of the Mesolithic from Alta, Finnmark, Norway, and of the beginning of the Eneolithic from Střelice, southwestern Moravia, Czech Republic." Acta Archaeologica Carpathica 56 (December 2021): 103–52. http://dx.doi.org/10.4467/00015229aac.21.005.15346.

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The ways of life of hunters, fishers and gatherers are noticeably different from those of farmers. Surviving evidence of their cultures is very rare. Although we are aware that it is very difficult to interpret and compare them, sometimes external similarities can be observed, such as in the depiction of human figures, particularly female figurines (also in zoomorphic sculptures) in the Upper Palaeolithic (‘the Cult of Hunters’) and in the Neolithic (‘Field Fertility Cult’ and ‘Domestic Animals Fertility Cult’). The depiction of a woman and three men with their arms stretched upwards on a famous vase of Moravian – East-Austrian group, Phase MOG IIa (around 4525–4375 BC) of the Painted Pottery culture from Střelice in the Czech Republic is significant, and has been interpreted by the author as an example of hieros gamos (i.e. a dialogue with space). This vase has considerable similarity with a petroglyph of a circular dance, again obviously depicting a woman and three men holding hands, from Alta in northern Norway, one of the central ‘galleries’ of hunters (5 stages, the oldest being 5300 BC). We can only assume (with just a certain amount of probability) that they depict a story (rite or myth?) in the form of a ‘language of symbols’ (e.g. a restoration of ‘Mother Earth’).

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Krysztofiak, Maria. "O pojmowaniu „rozwiązłości” w czasach przedchrześcijańskich: zjawisko prostytucji sakralnej." Studia et Documenta Slavica 10, no. 4 (November 20, 2020): 57–69. http://dx.doi.org/10.25167/setds/2019/4/5.

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The article presents the phenomenon of sacred prostitution which was characteristic of many ancient cultures and religions throughout the world. It shows a few of the most important issues connected with the sacred prostitution (also called religious or ritual): its origins (the cult of deities of love and fertility, typical of the pre-Christian cultures); its forms (one-time prostitution as an act of sacrificing one’s virginity or one-time sacrifice of a woman who was no longer a virgin, and constant prostitution practiced by priestesses or temple prostitutes); its main purposes (unification with deity, making a tribute to deity, pledge of the fertility of men, earth and animals by re-enactment of archetypical act of hieros gamos, the divine marriage). The article also analyses the religious anatomy of the phenomenon, basing on the thesis of Mircea Eliade; shows examples of sacred prostitution, taken mainly from The Golden Bough,the canonic work of Sir James George Frazer, and F.S. Pierre Dufour’s History of Prostitution; discusses the taboo of women’s blood on the basis of Jean-Paul Roux’s works; mentions the historical change in the meaning of the word “virgin” applying to Edward Whitmont’s statements; brings up controversies over the judgment of sacred prostitution as a historical phenomenon, referring to Edward Whitmont’s and Georg Baudler’s standpoints.

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Italiano, Antonio, Ernesto Amato, Lucrezia Auditore, and Sergio Baldari. "A methodological approach to a realistic evaluation of skin absorbed doses during manipulation of radioactive sources by means of GAMOS Monte Carlo simulations." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 891 (May 2018): 1–5. http://dx.doi.org/10.1016/j.nima.2018.02.075.

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Belezaca Pinargote, Carlos Eulogio, Diana Calle Gill, Oscar Prieto Benavides, Rolando López Tobar, Edison Solano Apuntes, and Fabricio Meza Bone. "Hongos formadores de micorriza arbuscular asociados a plantaciones de Ochroma pyramidale (Cav. ex Lam.) Urb. (balsa) en el Trópico Húmedo Ecuatoriano." Ciencia y Tecnología 12, no. 1 (September 12, 2019): 57–63. http://dx.doi.org/10.18779/cyt.v12i1.238.

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El objetivo de esta investigación fue conocer los géneros de hongos formadores de micorriza arbuscular (HMA) asociados a árboles de Ochroma pyramidale (balsa) en plantaciones y su grado de infección radicular. Se estudiaron seis plantaciones de 1, 2, 3, 4, 5.5 y 7 años de edad ubicadas en la zona central del Trópico Húmedo Ecuatoriano (THE), en cada una de ellas se delimitaron tres parcelas de 500 m2. En cada parcela se colectaron 3 muestras de suelo (aproximadamente 1 kg), y raicillas a una profundidad entre 0 – 15 cm para determinar el porcentaje de colonización micorrízica. El aislamiento e identificación de los HMA a nivel de género y la estimación de colonización micorrizica se realizó mediante la metodología de tamizado, decantación en húmedo con centrifugación, y despigmentación – tinción de raíces. Se aislaron e identificaron cuatro géneros de HMA: Glomus, Acaulospora, Scutellospora, y Gigaspora, no obstante, predominó el género Glomus en el suelo de todas las plantaciones estudiadas con poblaciones que estuvieron entre 27 y 169 esporas por 100 gamos de suelo seco, siendo la plantación de 4 años donde se encontró la mayor población, mientras que los demás géneros mostraron baja representatividad en todas las edades. Se detectó baja colonización micorrízica radicular en las plantaciones de balsa estudiadas, con rangos de 0.28% a 0.65%, porcentajes de colonización menores a los reportados para otras especies leñosas del THE.

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Belezaca Pinargote, Carlos, Diana Calle Gill, Oscar Prieto Benavides, Rolando López Tobar, Edison Solano Apuntes, and Fabricio Meza Bone. "Hongos formadores de micorriza arbuscular asociados a plantaciones de Ochroma pyramidale (Cav. ex Lam.) Urb. (balsa) en el Trópico Húmedo Ecuatoriano." Ciencia y Tecnología 12, no. 1 (July 9, 2020): 57–63. http://dx.doi.org/10.18779/cyt.v12i1.312.

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El objetivo de esta investigación fue conocer los géneros de hongos formadores de micorriza arbuscular (HMA) asociados a árboles de Ochroma pyramidale (balsa) en plantaciones y su grado de infección radicular. Se estudiaron seis plantaciones de 1, 2, 3, 4, 5.5 y 7 años de edad ubicadas en la zona central del Trópico Húmedo Ecuatoriano (THE), en cada una de ellas se delimitaron tres parcelas de 500 m2. En cada parcela se colectaron 3 muestras de suelo (aproximadamente 1 kg), y raicillas a una profundidad entre 0 – 15 cm para determinar el porcentaje de colonización micorrízica. El aislamiento e identificación de los HMA a nivel de género y la estimación de colonización micorrizica se realizó mediante la metodología de tamizado, decantación en húmedo con centrifugación, y despigmentación – tinción de raíces. Se aislaron e identificaron cuatro géneros de HMA: Glomus, Acaulospora, Scutellospora, y Gigaspora, no obstante, predominó el género Glomus en el suelo de todas las plantaciones estudiadas con poblaciones que estuvieron entre 27 y 169 esporas por 100 gamos de suelo seco, siendo la plantación de 4 años donde se encontró la mayor población, mientras que los demás géneros mostraron baja representatividad en todas las edades. Se detectó baja colonización micorrízica radicular en las plantaciones de balsa estudiadas, con rangos de 0.28% a 0.65%, porcentajes de colonización menores a los reportados para otras especies leñosas del THE.

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Paternò, Gianfranco, Michele Marziani, Riccardo Camattari, Valerio Bellucci, Andrea Mazzolari, Mauro Gambaccini, and Vincenzo Guidi. "Laue lens to focus an X-ray beam for radiation therapy." Journal of Applied Crystallography 49, no. 2 (February 24, 2016): 468–78. http://dx.doi.org/10.1107/s1600576716000716.

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A Laue lens is an optical component composed of a set of crystals that produce a convergent beam exploiting X-ray diffraction in transmission geometry. Employment of a system formed by a properly designed Laue lens coupled with an X-ray unit to selectively irradiate tumours is proposed. A convergent beam leads to a depth dose profile with a pronounced peak at the focal depth, which may result in a high precision of the dose delivery. Using a custom-made Monte Carlo code and the GAMOS code, we carried out a design study to determine the geometry and the optimal features of the crystals composing the lens. As an application, a Laue lens capable of focusing a 80 keV beam 50 cm downstream of the lens has been designed. The lens is composed of an ensemble of Si crystals with curved diffracting planes. The lens produces a focal spot of 2 mm enclosing 7.64 × 106 photons for an electron charge of 1 mC impinging on the surface of the X-ray tube anode. The combination of these important figures of merit makes the proposed system suitable for irradiating both sub-cm and larger tumour masses efficiently. A dose of 2 Gy can be delivered to a small tumour in a few seconds, sparing at the same time the surrounding tissues.

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Arce, Pedro, and Juan Ignacio Lagares. "CPU time optimization and precise adjustment of the Geant4 physics parameters for a VARIAN 2100 C/D gamma radiotherapy linear accelerator simulation using GAMOS." Physics in Medicine & Biology 63, no. 3 (January 25, 2018): 035007. http://dx.doi.org/10.1088/1361-6560/aaa2b0.

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Markus, Donka. "Anagogic Love between Neoplatonic Philosophers and Their Disciples in Late Antiquity." International Journal of the Platonic Tradition 10, no. 1 (February 29, 2016): 1–39. http://dx.doi.org/10.1163/18725473-12341331.

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Through a novel set of texts drawn from Plato, Porphyry, Plotinus, Ps. Julian, Proclus, Hermeias, Synesius and Damascius, I explore how anagogicerōsin master-disciple relationships in Neoplatonism contributed to the attainment of self-knowledge and to the transmission of knowledge, authority and inspired insights within and outside thediadochia. I view anagogicerōsas one of the most important channels of non-discursive pedagogy and argue for the mediating power of anagogicerōsin the attainment of the main goal of the Platonist: reorienting desire (erōs) from sensible to intelligible beauty and changing one’s ontological status to become like god and attain union with the divine. After considering the problematic nature of Socraticerōs, its skeptics and detractors, I discuss the dynamics of philosopher-disciple relationships and the experience of anagogicerōsin the following: the attack on Porphyry and defense by Plotinus following Porphyry’s recital of an ecstatic poem onHieros Gamos(Vita Plotini15), the concealment of anagogicerōsbehind the authoritative façade of an oracle (vp22-23), the intensely devotional private letters of Ps. Julian to the aged Iamblichus and of Synesius to his female master Hypatia; the identification of anagogicerōswith theurgic ascent in Syrianus’s school according to Proclus and Hermeias and the experiences of anagogicerōsoutside thediadochiain Damascius’Philosophical History. I conclude that the true and correct practice of philosophy had much, if not everything to do with the anagogicerōsbetween the true philosopher, the bacchant and the philosopher in training, aspiring to become transformed from thyrsus-bearer into bacchant. The privileged and exalted status given to the divine lover ensured the transmission of the philosophical tradition in all its richness, preserving both its discursive and non-discursive aspects as a system of thought, as a way of life and as a way of being and loving.

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Meaden, G. Terence. "Drombeg Stone Circle, Ireland, analyzed with respect to sunrises and lithic shadow-casting for the eight traditional agricultural festival dates and further validated by photography." Journal of Lithic Studies 4, no. 3 (November 15, 2017): 5–37. http://dx.doi.org/10.2218/jls.v0i0.1919.

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A new survey of Drombeg Stone Circle and accurate analysis of shadow effects beginning at particular sunrises of the calendar year has led to a breakthrough in the understanding of lithic symbolism and the intentions behind the construction of this and other Irish monuments including Knowth and Newgrange that also have astronomical alignments. At Drombeg specific standing stones play critical roles at sunrise for all eight of the festival dates as known traditionally and historically for agricultural communities and as now inferred for prehistoric times following the present observation-based analysis.Crucial for Drombeg in the summer half of the year is the positioning of a tall straight-sided portal stone such that its shadow at midsummer sunrise encounters an engraving on the recumbent stone diametrically opposite. During subsequent minutes the shadow moves away allowing the light of the sun to fall on the carved symbol. It is the same for sunrises at Beltane (May Day), Lughnasadh (Lammas), and the equinoxes when shadows from other perimeter stones achieve the same coupling with the same image, each time soon replaced by sunlight. For the winter half of the year which includes dates for Samhain, the winter solstice and Imbolc, the target stone for shadow reception at sunrise is a huge lozenge-shaped megalith, artificially trimmed. Moreover, for 22 March and 21 September there is notable dramatic action by shadow and light between a precisely positioned narrow pillar stone and the lozenge stone.As a result, at sunrise at Drombeg eight calendrical shadow events have been witnessed and photographed. This attests to the precision of Neolithic planning that determined the stone positions, and demonstrates the antiquity of the calendar dates for these traditional agricultural festivals. Discussion is held as to what the concept of shadow casting between shaped or engraved stones at the time of sunrise may have meant in terms of lithic symbolism for the planners and builders. This leads to a possible explanation in terms of the ancient worldview known as the hieros gamos or the Marriage of the Gods between Sky and Earth.

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Brikaa, Zheng, and Ammar. "Fuzzy Multi-objective Programming Approach for Constrained Matrix Games with Payoffs of Fuzzy Rough Numbers." Symmetry 11, no. 5 (May 22, 2019): 702. http://dx.doi.org/10.3390/sym11050702.

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Imprecise constrained matrix games (such as fuzzy constrained matrix games, interval-valued constrained matrix games, and rough constrained matrix games) have attracted considerable research interest. This article is concerned with developing an effective fuzzy multi-objective programming algorithm to solve constraint matrix games with payoffs of fuzzy rough numbers (FRNs). For simplicity, we refer to this problem as fuzzy rough constrained matrix games. To the best of our knowledge, there are no previous studies that solve the fuzzy rough constrained matrix games. In the proposed algorithm, it is proven that a constrained matrix game with fuzzy rough payoffs has a fuzzy rough-type game value. Moreover, this article constructs four multi-objective linear programming problems. These problems are used to obtain the lower and upper bounds of the fuzzy rough game value and the corresponding optimal strategies of each player in any fuzzy rough constrained matrix games. Finally, a real example of the market share game problem demonstrates the effectiveness and reasonableness of the proposed algorithm. Additionally, the results of the numerical example are compared with the GAMS software results. The significant contribution of this article is that it deals with constraint matrix games using two types of uncertainties, and, thus, the process of decision-making is more flexible.

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Gumede, Musa, Vusi Mazibuko, and Pumela Msweli. "Commonwealth Games: can Africa afford the games?" Public and Municipal Finance 6, no. 1 (April 5, 2017): 57–62. http://dx.doi.org/10.21511/pmf.06(1).2017.06.

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The Commonwealth Games Federation recently awarded the hosting of the 2022 Games to Durban, South Africa. This will be the first time the Games are hosted in the African continent. The paper looks into whether tangible benefits for hosting mega-events are less or more important than intangible benefits. In investigating this issue, the paper takes a political geography theoretical stance for its ability to provide normative ideological content for explaining intangible and tangible values for hosting Commonwealth Games. The paper looks at pros and cons for investing in mega-event infrastructure and also looks at the cost of hosting the Games for cities. The 2010 Commonwealth Games in Delhi budgeted $240 million for the entire Games, but the actual costs after the Games were found to be $1.7 billion. Similarly, in 2014 Glasgow, the cost of the Games was calculated at £575 million ($690 million). The paper looks at whether South Africa as the 2022 Commonwealth Games host can afford the games. It also considers the impact of the Games on national identity, national pride and patriotism here identified as novelty values that preserve social cohesion, a social attribute that has to be in place to build a robust economy. The paper concludes by noting that the success of the Games will depend on deliberate investment in catalytic facilities in areas that will be sustained post event. The amount of novelty value generated out of the Commonwealth Games will depend on how successful the Games are and on how the communities are able to interact with the facilities post event.

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Park, Leesun. "Before Entering Games: The Base and Accessibility of Games." Center for Asia and Diaspora 12, no. 2 (August 31, 2022): 103–40. http://dx.doi.org/10.15519/dcc.2022.08.12.2.103.

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Virtual reality is often considered a space independent of reality. A typical example of virtual reality is digital games. However, digital games can only run when there is a machine with an electrical signal. In addition, space for the machine to be installed is also essential. Until now, game studies have mainly dealt with the inside of the game based on the media attributes of the game. The outside of the game, for example, space or machines that form the physical foundation, has not received much attention. Before talking about the process of entering the game, discussions have already begun since accessing virtual reality. This study aims to showcase the barriers to entry in the game culture that is considered open to everyone and to urge research interest. We have chosen this approach as if we only discuss the difficulties after entering the game without imagining the process that has taken place beforehand, it will be difficult to see the inequality. Gaming is also a mobility phenomenon because it moves from reality to virtual reality. Kaufmann’s concept of motility is used as the theoretical background to explore this problem. By collecting and reading various previous studies such as mobility infrastructure, the digital divide, and the context of domestication of game consoles, this research aims to reveal the realistic conditions of virtual reality considered transparent today.

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M. Ferreira, Manuel Alberto, Maria Cristina Peixoto Matos, and José António Filipe. "Games in code form-introducing a new games representation." International Journal of Academic Research 6, no. 1 (January 30, 2014): 48–54. http://dx.doi.org/10.7813/2075-4124.2014/6-1/a.7.

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Tarnanas, Ioannis, Winfried Schlee, Magda Tsolaki, René Müri, Urs Mosimann, and Tobias Nef. "Ecological Validity of Virtual Reality Daily Living Activities Screening for Early Dementia: Longitudinal Study." JMIR Serious Games 1, no. 1 (August 6, 2013): e1. http://dx.doi.org/10.2196/games.2778.

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Jaffer, Usman, Nigel W. John, and Nigel Standfield. "Surgical Trainee Opinions in the United Kingdom Regarding a Three-Dimensional Virtual Mentoring Environment (MentorSL) in Second Life: Pilot Study." JMIR Serious Games 1, no. 1 (September 20, 2013): e2. http://dx.doi.org/10.2196/games.2822.

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Clemente, Miriam, Beatriz Rey, Aina Rodriguez-Pujadas, Juani Breton-Lopez, Alfonso Barros-Loscertales, Rosa M. Baños, Cristina Botella, Mariano Alcañiz, and Cesar Avila. "A Functional Magnetic Resonance Imaging Assessment of Small Animals’ Phobia Using Virtual Reality as a Stimulus." JMIR Serious Games 2, no. 1 (June 27, 2014): e6. http://dx.doi.org/10.2196/games.2836.

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