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1
Bleeker, M. "Aeolus Press awards first Orbit Medal to Gabe M. Bleeker Gabe." Orbit 9, no. 4 (January 1990): 203–4. http://dx.doi.org/10.3109/01676839009019285.
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Betz, Daniela Simon. "Intranasale Applikation von Medetomidin bei Hunden." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 48, no. 01 (February 2020): 56–57. http://dx.doi.org/10.1055/a-1079-3270.
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Jafarbeglou M, Marjani M. Comparison of the sedative effects of medetomidine administered intranasally, by atomization or drops, and intramuscular injection in dogs. Vet Anaesth Analg 2019; 46: 815–819 Die intranasale Gabe stellt eine nicht invasive und praktische Form der Medikamentenapplikation dar. Die hochvaskularisierte Mukosa der Nasenhöhle ermöglicht eine schnelle Absorption und ein direkter Nasen-Hirn-Transport kann unter Umgehung der Blut-Hirn-Schranke über die Nn. olfactorii und trigemini sowie die Zerebrospinalflüssigkeit effektive Wirkstoffkonzentrationen im Zentralnervensystem bewirken. Ziel dieser Studie war, die sedative Effektivität von intranasal – per Zerstäuber oder in Tropfenform – appliziertem Medetomidin im Vergleich zur intramuskulären Gabe zu untersuchen.
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red. "M. Menière: intratympanale Gabe von Methylprednisolon so wirksam wie Gentamicin." HNO Nachrichten 47, no. 4 (August 2017): 17. http://dx.doi.org/10.1007/s00060-017-5484-9.
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Pohlmann, Birgit. "Ovarialkarzinom: Diskussion um Therapiestandard in der Primärtherapie." Onkologische Welt 03, no. 04 (2012): 177–78. http://dx.doi.org/10.1055/s-0038-1630206.
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In der Primärtherapie des Ovarialkarzinoms wird die Frage diskutiert, ob die wöchentliche Gabe von Paclitaxel (80 mg/m², Tag 1,8,15) plus Carboplatin (AUC 6, Tag 1, q3W) (dd-TC) das etablierte 3-wöchentliche Regime mit Paclitaxel (180 mg/m², Tag 1) plus Carboplatin (AUC 6, Tag 1) (c-TC) als Standard in der Primärtherapie des epithelialen Ovarialkarzinoms ablösen. Eine endgültige Klärung steht jedoch noch aus, erläuterte Prof. Andreas du Bois, Essen.
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Wolf, Ingrid, Brendan J. Jenkins, Yan Liu, Martina Seiffert, Joseph M. Custodio, Paul Young, and Larry R. Rohrschneider. "Gab3, a New DOS/Gab Family Member, Facilitates Macrophage Differentiation." Molecular and Cellular Biology 22, no. 1 (January 1, 2002): 231–44. http://dx.doi.org/10.1128/mcb.22.1.231-244.2002.
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ABSTRACT Using the FDC-P1 cell line expressing the exogenous macrophage colony-stimulating factor (M-CSF) receptor, Fms, we have analyzed the role of a new mammalian DOS/Gab-related signaling protein, called Gab3, in macrophage cell development of the mouse. Gab3 contains an amino-terminal pleckstrin homology domain, multiple potential sites for tyrosine phosphorylation and SH2 domain binding, and two major polyproline motifs potentially interacting with SH3 domains. Among the growing family of Gab proteins, Gab3 exhibits a unique and overlapping pattern of expression in tissues of the mouse compared with Gab1 and Gab2. Gab3 is more restricted to the hematopoietic tissues such as spleen and thymus but is detectable at progressively lower levels within heart, kidney, uterus, and brain. Like Gab2, Gab3 is tyrosine phosphorylated after M-CSF receptor stimulation and associates transiently with the SH2 domain-containing proteins p85 and SHP2. Overexpression of exogenous Gab3 in FD-Fms cells dramatically accelerates macrophage differentiation upon M-CSF stimulation. Unlike Gab2, which shows a constant mRNA expression level after M-CSF stimulation, Gab3 expression is initially absent or low in abundance in FD cells expressing the wild-type Fms, but Gab3 mRNA levels are increased upon M-CSF stimulation. Moreover, M-CSF stimulation of FD-FmsY807F cells (which grow but do not differentiate) fails to increase Gab3 expression. These results suggest that Gab3 is important for macrophage differentiation and that differentiation requires the early phosphorylation of Gab2 followed by induction and subsequent phosphorylation of Gab3.
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Kurtaran, A., E. Havlik, and J. Preitfellner. "Strahlenexposition in der Umgebung von Patienten nach Gabe von 99mTc-DPD." Nuklearmedizin 34, no. 04 (1995): 151–55. http://dx.doi.org/10.1055/s-0038-1629817.
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ZusammenfassungBei 16 Patienten wurden innerhalb der ersten 4 h nach Applikation von 600 ± 30 MBq 99mTc-DPD die Ortsdosisleistungen in 0,5, 1 und 2 m Entfernung von der Körperoberfläche gemessen. Die unterschiedlichen, individuellen Dosisleistungsverläufe werden an drei Beispielen diskutiert. Aus den Messungen wurden die Strahlendosen in der Umgebung der Patienten bestimmt und die mögliche Strahlenexposition anderer Patienten, der Begleitpersonen und des Pflegepersonals in der Umgebung der »strahlenden« Patienten abgeschätzt. Die Personendosen lagen deutlich unterhalb der durch die Strahlenschutzbestimmungen festgelegten Grenzwerte.
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Schröder, Christoph, Johannes Roeles, Adrian Schwarzer, Michael Heuser, Jennifer Retzlaff, and Marcus Hiß. "Therapierefraktäre Anämie bei einem 35-jährigen Dialysepatienten nach Herztransplantation." Der Internist 62, no. 7 (February 12, 2021): 768–71. http://dx.doi.org/10.1007/s00108-021-00955-9.
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ZusammenfassungEs wird über einen 35-jährigen Dialysepatienten nach Herztransplantation berichtet, der eine „pure red cell aplasia“ aufwies. Serologisch fand sich ein positiver Parvovirus-B19-Immunglobulin-M-Titer, im Direktnachweis mittels Polymerase-Kettenreaktion zeigten sich 80 Mrd. IU/ml. In der zytologischen Untersuchung des Knochenmarks gelang der Nachweis von Riesenproerythroblasten, pathognomonisch für eine Parvovirus-B19-Infektion. Zur Therapie erfolgte die hoch dosierte Gabe von Immunglobulinen über 5 Tage. Bei Wiedervorstellung nach vier Wochen zeigte sich die Anämie deutlich gebessert. Bei Patienten nach Organtransplantation mit hyporegenerativer Anämie sollte eine Parvovirus-B19-Infektion stets ausgeschlossen werden.
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Santazilia, Ekaitz. "Zaraitzueraren lekukotasunak XVIII. mende bukaeran: hiru testu zahar eta autore berri bat." Fontes Linguae Vasconum, no. 121 (June 21, 2016): 67–120. http://dx.doi.org/10.35462/flv121.2.
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Zaraitzuko euskaran XVIII. mendean idatzitako hiru prediku aztertu ditugu lan honetan. Ez daude hirurak egoera berean, izan ere, bat argitaragabea izan arren, beste biak J. M. Satrustegik emanak zituen jadanik argitara; gainera, ez dira denak batera leku berean gordetzen. Hartara, lau zeregini ekin diegu: Alde batetik, testuek izenik ez baitute, argitaratu gabe dagoen testuak eta Satrustegik ateratakoak esku berak idatziak direla frogatu dugu. Bigarrenik, balizko autorea zein den aurkitu eta haren biografia apur bat ikertu dugu. Ondoren, hiru testuen transkripzio eta edizio bateratua eskaini dugu, eta testuek erakusten duten hizkeraren hizkuntza-azterketa egin, azkenik.
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Danowski, Klaus. "Bewährte Indikationen von Natrium muriaticum in der Veterinärmedizin." Allgemeine Homöopathische Zeitung 263, no. 06 (November 2018): 15–19. http://dx.doi.org/10.1055/a-0741-7575.
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ZusammenfassungEs werden 4 häufige Indikationen vorgestellt. Zuerst ein Fall von Depression bei einem Wellensittich mit begleitender Nierenerkrankung. Nach einer Gabe C1000 war innerhalb von 4 Wochen wieder ein normales Verhalten zu beobachten. Der 2. Fall berichtet von einem Terrier mit Nüchternerbrechen. Als Ursache wurde eine Hyperchlorämie festgestellt. Nat-m. in C200 beendete das Erbrechen nach 8 Wochen und steigerte die Fitness deutlich. Das 3. Beispiel handelt von unkontrolliertem Harnabsatz. Der Irish Setter litt unter einer Nierenentzündung mit Überlaufblase. Grundproblematik war eine ausgeprägte Futterallergie. Begleitend bestand ein juckender Hautausschlag. Mit Tuberculinum Koch C1000 und Nat-m. C1000 heilten die Beschwerden innerhalb von 11 Wochen. Der letzte Fall schildert einen typischen Hautausschlag, ein sog. miliares Ekzem bei einer Stubenkatze. Nat-m. in C200 mehrmals pro Woche führte über einen interkurrenten Zahnwurzelabszess nach 3 Monaten zur Beschwerdefreiheit. Zuletzt wird von seit 1 Jahr bestehenden starken konkurrenzbedingten Spannungen mit der 2. Katze im Haus berichtet.
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Fallbericht, Ein, K. H. Amort, J. Bokemeyer, M. Kramer, and A. M. Fiedler. "Muskulotendinopathie des Musculus gastrocnemius bei einem Labrador Retriever." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 41, no. 05 (2013): 349–54. http://dx.doi.org/10.1055/s-0038-1623720.
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ZusammenfassungDie Muskulotendinopathie des Musculus (M.) gastrocnemius stellt eine seltene Erkrankung des Ursprungs dieses Muskels dar, die durch eine chronische Überbelastung des Muskel-Sehnen-Übergangs beim Sporteinsatz entsteht und zumeist bei Hütehunden beschrieben wurde. Klinisch zeigen die Patienten eine chronische Hinterhandlahmheit sowie Schmerzhaftigkeit bei Druck auf die laterale Fabella. Eine Kniegelenkinstabilität fehlt. Radiologische Befunde (osteophytäre Neuformationen im Bereich des Muskelursprungs und der lateralen Fabella) geben ebenfalls Hinweise auf das Vorliegen der Erkrankung. In der magnetresonanztomographischen Untersuchung zeigen sich Ödeme im Bereich des Ursprungs des lateralen Gastrocnemiuskopfes und eine Anreicherung von Kontrastmittel nach intravenöser Applikation. Die Muskulotendinopathie des M. gastrocnemius hat bei konsequenter konservativer Therapie (Ruhighaltung, Gabe nichtsteroidaler Antiphlogistika und Physiotherapie) eine gute Prognose. Der Fallbericht beschreibt die klinischen Befunde, bildgebende Diagnostik (Röntgen und Magnetresonanztomographie) sowie die Therapie und das Langzeitergebnis dieser Erkrankung bei einem sportlich geführten Labrador Retriever.
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Süssmuth, S., H. J. Maxon, and E. Pinkhardt. "Botulinumtoxin als Therapieoption bei clozapininduzierter Hyper-salivation." Nervenheilkunde 28, no. 09 (2009): 649–51. http://dx.doi.org/10.1055/s-0038-1628682.
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ZusammenfassungDie Behandlung der Hypersalivation mit Injektionen von Botulinumtoxin (BTx) in die Glandula parotis ist eine etablierte Therapie, die bei verschiedenen neurologischen Erkrankungen wie M. Parkinson oder Multipler Sklerose erfolgreich angewendet wird. Die clozapininduzierte Hypersalivation (CIH), eine bekannte und häufig für den Patienten äußerst einschränkende unerwünschte Medikamentenwirkung, ist eine weitere mögliche Indikation für die Behandlung mit BTx, für die es bisher nur wenige Einzelfallberichte gibt. Im vorgestellten Fall konnten wir durch die Gabe von BTx bei einer Patientin mit CIH nicht nur die Speichelsekretion erheblich reduzieren, sondern wir beobachteten darüber hinaus eine Verbesserung der Angstsymptomatik, die mit der weiterhin möglichen hochdosierten Clozapinmedikation und mit der Abschwächung des sozial stigmatisierenden Speichelflusses in Zusammenhang stehen könnte.
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Wagner, D., and C. Lange. "Lungenerkrankung durch nicht-tuberkulöse Mykobakterien." Pneumologie 74, no. 11 (November 2020): 773–79. http://dx.doi.org/10.1055/a-1227-9885.
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ZusammenfassungDie neue ATS/ERS/ESCMID/IDSA-Leitlinie beantwortet 22 PICO-Fragen zur Behandlung von Erkrankungen der Lunge durch Mycobacterium avium-Komplex (MAC), M. kansasii, M. xenopi und M. abscessus. Allgemeines Insbesondere bei Patienten mit mikroskopischem Nachweis säurefester Stäbchen im Sputum oder kavernöser Verlaufsform sollte der Behandlungsbeginn nicht verzögert werden. Die Behandlung sollte auf einer speziesspezifischen Resistenztestung (entsprechend den CLSI-Guidelines) basieren. MAC-Lungenerkrankung Die Therapie erfolgt hier mit mindestens 3 Medikamenten inklusive einem Makrolid (eher Azithromycin als Clarithromycin) und Ethambutol. Für Patienten mit kavitärer, mit ausgeprägter nodulär-bronchiektatischer Erkrankung oder mit Makrolid-Resistenz wird zur täglichen oralen Therapie eine additive Gabe von parenteralem Amikacin oder Streptomycin empfohlen. Liposomal verkapseltes inhalatives Amikacin wird bei Therapieversagen empfohlen. Patienten mit nodulär-bronchiektatischer Erkrankungsmanifestation sollten eine orale Makrolid-basierte Therapie, die – je nach Ausmaß – 3 ×/Woche gegeben werden kann, erhalten. Als Dauer werden 12 Monate nach Konversion der Sputumkultur empfohlen. M. kansasii-Lungenerkrankung Empfohlen ist die Dreifachkombination aus Rifampicin, Ethambutol und Makrolid (oder Isoniazid ) für mindestens 12 Monate. Bei Rifampicin-Resistenz oder -unverträglichkeit wird Moxifloxacin als Ersatz empfohlen. M. xenopi-Lungenerkrankung Empfohlen ist die Dreifachkombination aus Rifampicin, Ethambutol und Makrolid (oder Moxifloxacin) für mindestens 12 Monate nach Konversion der Sputumkultur. Es wird empfohlen, bei Patienten mit kavernöser Verlaufsform zumindest parenterales Amikacin zu addieren und Experten zu konsultieren. M. abscessus-Lungenerkrankung Mindestens 3 Medikamente werden zur Therapie empfohlen. Die Substanzauswahl sollte auf einer In-vitro-Resistenztestung basieren. Makrolide sind die Grundlage, sollten aber bei Stämmen mit induzierbarer Makrolidresistenz nicht mitgerechnet werden. Zur Therapiedauer werden aufgrund fehlender Daten keine expliziten Empfehlungen ausgesprochen, eine Konsultation von Experten wird empfohlen.
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Wagner, Dirk, and Christoph Lange. "Lungenerkrankung durch nicht-tuberkulöse Mykobakterien – Die neue ATS/ERS/ESCMID/IDSA-Leitlinie." DMW - Deutsche Medizinische Wochenschrift 145, no. 16 (August 2020): 1145–51. http://dx.doi.org/10.1055/s-0043-124159.
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Was ist neu?Die neue ATS/ERS/ESCMID/IDSA-Leitlinie beantwortet 22 PICO Fragen zur Behandlung von Erkrankungen der Lunge durch Mycobacterium avium-Komplex (MAC), M. kansasii, M. xenopi und M. abscessus. Allgemeines Insbesondere bei Patienten mit mikroskopischem Nachweis säurefester Stäbchen im Sputum oder kavernöser Verlaufsform sollte der Behandlungsbeginn nicht verzögert werden. Die Behandlung sollte auf einer speziesspezifischen Resistenztestung (entsprechend den CLSI-Guidelines) basieren. MAC-Lungenerkrankung Die Therapie erfolgt hier mit mindestens 3 Medikamenten inklusive einem Makrolid (eher Azithromycin als Clarithromycin) und Ethambutol. Für Patienten mit kavitärer, mit ausgeprägter nodulär-bronchiektatischer Erkrankung oder mit Makrolid-Resistenz wird zur täglichen oralen Therapie eine additive Gabe von parenteralem Amikacin oder Streptomycin empfohlen. Liposomal verkapseltes inhalatives Amikacin wird bei Therapieversagen empfohlen. Patienten mit nodulär-bronchiektatischer Erkrankungsmanifestation sollten eine orale Makrolid-basierte Therapie, die – je nach Ausmaß – 3-mal/Woche gegeben werden kann, erhalten. Als Dauer werden 12 Monate nach Konversion der Sputumkultur empfohlen. M. kansasii-Lungenerkrankung Empfohlen ist die Dreifachkombination aus Rifampicin, Ethambutol und Makrolid (oder Isoniazid) für mindestens 12 Monate. Bei Rifampicin-Resistenz oder -unverträglichkeit wird Moxifloxacin als Ersatz empfohlen. M. xenopi-Lungenerkrankung Empfohlen ist die Dreifachkombination aus Rifampicin, Ethambutol und Makrolid (oder Moxifloxacin) für mindestens 12 Monate nach Konversion der Sputumkultur. Es wird empfohlen, bei Patienten mit kavernöser Verlaufsform zumindest parenterales Amikacin zu addieren und Experten zu konsultieren. M. abscessus-Lungenerkrankung Mindestens 3 Medikamente werden zur Therapie empfohlen. Die Substanzauswahl sollte auf einer In-vitro-Resistenztestung basieren. Makrolide sind die Grundlage, sollten aber bei Stämmen mit induzierbarer Makrolidresistenz nicht mitgerechnet werden. Zur Therapiedauer werden aufgrund fehlender Daten keine expliziten Empfehlungen ausgesprochen, eine Konsultation von Experten wird empfohlen.
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González-Saldaña, Napoleon, José Iván Castillo-Bejarano, Marte Hernández-Porras, Eduardo Arias de la Garza, Sofia Fortes-Gutiérrez, Jose Luis Copado-Gutiérrez, and Hugo Juarez-Olguin. "Koinfektion mit Streptococcus anginosus und Mycobacterium tuberculosis bei einem immunkompetenten pädiatrischen Patienten. Ein Fallbericht." Kompass Pneumologie 8, no. 4 (2020): 227–30. http://dx.doi.org/10.1159/000508635.
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Hintergrund: Koinfektionen bei Tuberkulose (TB) sind selten. Eine Mischinfektion mit der Streptococcus-anginosus-Gruppe (SAG) und M. tuberculosis (MTB) wurde bei Kindern bislang noch nicht berichtet. Ziel dieses Berichts war die Beschreibung eines pädiatrischen Falls mit Lungenabszess infolge einer SAG-MTB-Doppelinfektion. Fallvorstellung: Ein 11-jähriger Junge mit vor zwei Tagen akut aufgetretenen pulsierenden Schmerzen in der vorderen Brustwand. Der Patient berichtet über Fieber, Husten und Nasenlaufen in den vergangenen sieben Tagen. Die anteriore Thorax-Röntgenaufnahme ergab eine heterogene Verschattung am rechten Unterlappen, und die laterale Projektion zeigte eine Obliteration an der vorderen Zwerchfellinsertion. Die parenterale Gabe von Ceftriaxon (100 mg/kg/Tag) und Dicloxacillin (200 mg/kg/Tag) wurde eingeleitet. Der Abszess wurde anschließend drainiert und analysiert. Nach einjähriger Nachbeobachtung blieb der Patient weiterhin asymptomatisch. Schlussfolgerung: Dies ist unseres Wissens der erste berichtete Fall einer pulmonalen Koinfektion mit MTB und SAG bei einem immunkompetenten pädiatrischen Patienten.
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Birkhäuser. "Indications for Hormone Replacement Therapy." Therapeutische Umschau 57, no. 10 (October 1, 2000): 635–42. http://dx.doi.org/10.1024/0040-5930.57.10.635.
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Nach der Menopause kann es als Folge des Östrogenmangels einerseits zum klimakterischen Syndrom und andererseits zu Stoffwechselveränderungen mit möglichen Folgeerkrankungen kommen. Bei symptomatischen Östrogenmangelzuständen ist eine Hormonsubstitution aus therapeutischen Erwägungen indiziert. Besteht ein erhöhtes Risiko für Osteoprose, kardiovaskuläre Erkrankungen oder M. Alzheimer muss eine Prävention mit Östrogenen diskutiert werden. Sie ist bei gleichzeitigen subjektiven Beschwerden die Therapie der Wahl. Unsachgemäße Darstellungen in den Medien führen immer wieder zur Verunsicherung und zu Bedenken gegenüber der Anwendung von Sexualhormonen. Durch eine HET kann es zu einer leichten Gewichtszunahme von 200–500 g kommen. Wichtiger ist aber die altersabhängige Tendenz zur Gewichtszunahme. Die postmenopausale Substitution führt zu keiner erhöhten Hypertonie-Inzidenz. Sind in der persönlichen oder der Familienanamnese Hinweise auf eine Thrombophilie gegeben, so sollte vor Substitutionsbeginn eine Thrombophilieabklärung erfolgen. Das Risiko, unter korrekter Östrogen/Gestagen-Substitution an einem Endometrium-Karzinom zu erkranken, ist nicht erhöht. Eine vermehrte Häufigkeit von Endometrium-Karzinomen findet sich hingegen bei Frauen mit intaktem Uterus unter alleiniger Gabe von Östrogenen. Die Häufigkeit des Mammakarzinomes nimmt mit dem Alter kontinuierlich zu. Wird bei 1000 Frauen im Alter von 50 Jahren eine Hormonsubstitution begonnen, so nimmt die Zahl der Mamma-Ca-Diagnosen in den folgenden 20 Jahren um zwei Fälle zu, wenn die Dauer der Hormongabe fünf Jahre beträgt. Die nach der Reanalyse epidemiologischer Studien errechnete geringfügige Erhöhung der Mammakarzinominzidenz durch eine Hormonsubstitution ist aber nicht mit einer erhöhten Mortalität an Brustkrebs unter HET verbunden. Die bisher vorliegenden Daten mit einer deutlichen Senkung der Gesamt-Mortalität bis zum Alter von 75 Jahren sprechen zu Gunsten der Hormonsubstitution. Bei einer Gabe zur Behandlung des klimakterischen Syndroms bis zu fünf Jahren besteht kein Hinweis auf eine Erhöhung des Risikos, an einem Karzinom zu erkranken. Der Gewinn an Lebensqualität steht eindeutig im Vordergrund. Für die Indikation einer langfristigen Hormonsubstitution müssen aber in jedem Falle die Vorteile einer Prävention gegenüber den möglichen Risiken abgewogen werden.
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Liu, Jian. "Stage text of the musical «Next to normal» in Michael Grief’s production." Problems of Interaction Between Arts, Pedagogy and the Theory and Practice of Education 57, no. 57 (March 10, 2020): 212–27. http://dx.doi.org/10.34064/khnum1-57.13.
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Theoretical Background. The concept of stage text is actualized in musical science in the context of a variety of samples of director’s theater, in which the stage decision may dissonant or act as a counterpoint to the original musical (ie compositional) text of the work. Sometimes the musical score is only the starting point for the director’s version. T. Grigoryants (2007), M. Kosilkin (2017), M. Kuklinska (2018; 2020) turn to the analysis of the stage text. Among the parameters that M. Kosilkin draws attention to are psychological types (2017: 85), which are embodied through facial expressions and gestures, plasticity and movements, the appearance of the character; and a set of pictorial means – costumes, objects and decorations. Unlike traditional opera, the director of a Broadway musical of the XXI century (especially on modern plots), as a rule, does not face the problem of modernization of stage means or compliance of the stage solution with the expectations and inertia of the audience. However, within this genre it is important to understand what aesthetic tasks are solved by this or that production and what happens in the dynamics of the stage life of the musical, whether the elements of the stage text are written in the score, or, conversely, the director is required to find a solution. Objectives. The aim is to identify the features of the stage text of the musical «Next to normal» – its main components and functions in relation to the musical score. In accordance with the purpose, such methods are used as comparative (to compare the composer’s and stage texts), structural and functional (to identify individual elements of the stage text and their role in revealing the plot and dramaturgy of the whole). Results and Discussion. Unlike directorial experimentalism in the field of opera, where the score may lose “its leading role, giving way to the leadership of a musical performance” (Kuklinskaya, 2020), the Broadway musical «Next to normal» illustrates the unity of the composer and director who seek to be understood by the public. Last but not least, this is due to the fact that some elements of the plot are so cinematic that they seem to be inaccessible for the implementation of purely musical and stage means. Thus, the stage realization of the image of a ghost, various «flashbacks» (№ 5), the delimitation of frames of parallel action (№ 16), the release of Diana’s consciousness during ECT (№ 18) is extremely difficult. However, the director manages to do it with minimal means, without involving special effects. Among the most important tools for creating stage text are: ● two-level stage with different sectors allows to implement fast spacetime switching while maintaining the dynamics of action and embody the idea of parallel action, a combination of real and imaginaryevents; ● the light – directed to the relevant sector of the scene, emphasizes a particular character or pair of characters, focusing the teacher’s attention on a particular plane of action; another approach – even illumination of different sectors of the scene, aimed at; ● concise props (sandwiches, trash can, candle cake, photo, box) – brings to the surface hidden subtexts and reveals the psychological characteristics of the characters hidden in the musical text, ie performs the function of objectification, specification of certain events; ● gestures – turns of the head and body of the characters indicate their «relationship» with the ghost. Since for Diana he is real, so she always turns to him. The other characters behave as if Gabe is not on the stage, and only at turning points do they begin to see him (Dan in № 37); the idea of flashback (Diana’s memories of her marriage to Dan) – is realized through a gesture – a woman reaches out to hug her husband, but catches the emptiness; ● stage action of the characters and mise-en-scène – excessive gestures and strange movements make Diana go crazy; dance and choreographic elements (Dr. Madden, Diana and Gabe), skating on the operating table (Gabe, doctors) highlight the unreal elements of the plot; the main character’s hugs with Gabe illustrate her choice in favor of a ghostly world over the real one (her husband, Dan); ● scenery – demonstratively minimalistic – it consists of key objects – the dining table symbolizes the Goodman family home, the operating room – the hospital, a comfortable chair – psychotherapy sessions; ● costumes – deserve the least attention of the directors, as the household plot focuses on everyday clothes (jeans, sweater, shirt, etc.); against this background, the dance of Gabe and Diana stands out, where they are both in white (№ 4), which gives the action a hidden subtext; white can also be seen as a symbol of madness (Diana’s shirt in the hospital). Conclusions.In terms of musical content, the production deepens the tragedy of Diana’s image, which is that she chooses a ghostly man instead of a real one. And the relationship between her and her dead son in the stage decision goes beyond the roles of «mother – son» – as evidenced by their dance, kissing hands, hugs, which allow us to consider them as a romantic couple of characters, which in the musical text of the opera is only a hint. Thus, the stage text of the musical «Next to normal» is aimed at concretizing the musical content, working with simple symbols that will be understandable to the public, and on the other– to deepen the content and multifaceted disclosure of the ghost world, hallucinations, mental disorders and madness.
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von Amsberg, Gunhild, and Carsten Bokemeyer. "Neue Aspekte in der Therapie des metastasierten Prostatakarzinoms." DMW - Deutsche Medizinische Wochenschrift 142, no. 15 (June 23, 2017): 1106–10. http://dx.doi.org/10.1055/s-0043-105768.
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Was ist neu? Hormon-Chemotherapie in der hormonsensitiven Situation Basierend auf den Ergebnissen dreier großer, randomisierter Studien (STAMPEDE, CHAARTED und GETUG15) sollte Patienten mit metastasiertem, hormonsensitivem Prostatakarzinom (PCa) eine kombinierte Hormon-Chemotherapie mit Docetaxel 75 m/qm alle 3 Wochen über 6 Zyklen angeboten werden. Cabazitaxel bei metastasiertem, kastrationsresistentem Prostatakarzinom (mCRPC) Eine Reduktion der Cabazitaxel-Dosierung von 25 mg/qm auf 20 mg/qm als Zweitlinien-Chemotherapie nach Docetaxel scheint ohne wesentlichen Wirkverlust möglich zu sein, bei zugleich deutlich besserer Verträglichkeit. Die Gabe von Cabazitaxel vor Docetaxel bei kastrationsrefraktärem PCa hat keinen Zusatznutzen. Androgenrezeptor (AR)-gerichtete Behandlungen bei mCRPC Die AR-gerichteten Medikamente Enzalutamid und Abirateron stellen interessante Behandlungsalternativen zur klassischen Chemotherapie dar, da der AR trotz Kastrationsresistenz eine Schlüsselrolle bei der Tumorprogression innehat. Einsatz von Radium-223 bei ossär metastasierten Patienten Als erstes Medikament dieser Substanzklasse führte Radium-223 bei Patienten mit rein ossär metastasiertem, kastrationsresistentem Prostatakarzinom zu einer signifikanten Verlängerung des Gesamtüberlebens. Entscheidungshilfen für die Medikamentenauswahl Erkrankungs- und patientenspezifische Charakteristika sollten bei der Auswahl des richtigen Medikaments berücksichtigt werden.
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Jiang, Zhen, Jie Wang, Fenghui Zhang, Li-Xin Li, Lan Wang, Ran Li, Liang Gao, Zhanwen Han, and Jun Pan. "Simulating kilonovae in the ΛCDM universe." Monthly Notices of the Royal Astronomical Society 498, no. 1 (July 9, 2020): 926–39. http://dx.doi.org/10.1093/mnras/staa1989.
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ABSTRACT Kilonovae are optical flashes produced in the aftermath of neutron star–neutron star mergers or neutron star–black hole mergers. In this work, we use the Millennium Simulation, combined with semi-analytic galaxy formation model gabe (Galaxy Assembly with Binary Evolution) to explore the cosmic event rate of kilonovae, and the properties of their host galaxies in a cosmological context. We find that model with supernova kick velocity of $V_{\rm kick}=0\, \, {\rm km}\, \, {\rm s}^{-1}$ fits the observation best, satisfying the preference for low kick velocity binary system in theoretical models. With $V_{\rm kick}=0\, \, {\rm km}\, \, {\rm s}^{-1}$, the cosmic event rate of NNMs and NBMs at z = 0 are 283 and $91\, \, {\rm Gpc}^{-3}\, \, {\rm yr}^{-1}$, respectively, marginally consistent with the constraint from LVC GWTC-1. For Milky Way-mass galaxies, we predict the NNM rate is $25.7^{+59.6}_{-7.1}\, {\rm Myr}^{-1}$, which is also in good agreement with the observed properties of binary neutron stars in the Milky Way. Taking all the kilonovae into account in the history of Milky Way-mass galaxies, we find that the averaged r-process elements yield (A > 79) in an NNM/NBM event should be $0.01\, {\rm M}_\odot$ to be consistent with observation. We conclude that NGC 4993, the host galaxy of GW170817, is a typical host galaxy for NNMs. However, generally, NNMs and NBMs tend to reside in young, blue, star-forming, late-type galaxies, with stellar mass, and gaseous metallicity distribution peaking at $M_{\rm *}=10^{10.65}\, {\rm M}_\odot$ and 12 + log (O/H) = 8.72 − 8.85, respectively. By exploring the connection between kilonovae and their host galaxies in the cosmological background, it is promising to constrain model better when we have more events in the forthcoming future.
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Nishihara, Hirotomo. "(Invited) Graphenemesosponge: A New Carbon Material with High Porosity and High Durability for Battery Applications." ECS Meeting Abstracts MA2022-01, no. 10 (July 7, 2022): 782. http://dx.doi.org/10.1149/ma2022-0110782mtgabs.
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There are many kinds of carbon materials such as activated carbons, nanoporous carbons, carbon blacks, graphite, carbon nanotubes, carbon nanofibers, and graphene-like materials, and they have been used in a variety of batteries as active materials, conductive additives, and gas diffusion layers. Depending on the purpose of use, carbon materials are required to have appropriate porosity, electric conductivity, mechanical stability, and electrochemical stability. While the above mentioned carbon materials have individual advantages and disadvantages, it has been a challenging target to develop next-generation carbon materials to satisfy all the necessary requirements at the same time. In this talk, a new class of carbon material, “graphene mesosponge (GMS)”, is introduced as a feasible candidate [1]. GMS is synthesized by a hard-templating method using Al2O3 [1] or MgO [2] nanoparticles via precisely controlled chemical-vapor deposition in which the average stacking number of graphene sheets is adjusted to 1. After template removal, the resulting mesoporous carbon is annealed at 1800 °C to form GMS. By such a high-temperature treatment, most of carbon edge sites which cause corrosion of batteries can be removed, and GMS exhibits ultra-high stability against chemical oxidation as well as electrochemical oxidation. Despite such durability, GMS possess a high surface area (ca. 2000 m2/g) and a large pore volume (> 3 cm3/g). Moreover, GMS has a high electric conductivity which is superior to carbon blacks. Furthermore, GMS is mechanically flexible and tough. GMS shows reversible deformation and recovery upon applying mechanical force and its removal [3]. Such unique properties of GMS enable its use as next-generation durable and high-performance carbon material to battery applications. As an electrode material for electric double-layer capacitors, GMS exhibits ultra-high voltage stability up to 4.4 V even in a conventional organic electrolyte (Et3MeN/BF4), which surpass single-walled carbon nanotubes [4]. Also, GMS is useful to a Pt support of polymer-electrolyte fuel cells [5] and to a cathode of Li-air batteries. References [1] H. Nishihara, T. Simura, S. Kobayashi, K. Nomura, R. Berenguer, M. Ito, M. Uchimura, H. Iden, K. Arihara, A. Ohma, Y. Hayasaka, T. Kyotani, Adv. Funct. Mater. 2016, 26, 6418-6427. [2] S. Sunahiro, K. Nomura, S. Goto, K. Kanamaru, R. Tang, M. Yamamoto, T. Yoshii, J. N. Kondo, Q. Zhao, A. Ghulam Nabi, R. Crespo-Otero, D. Di Tommaso, T. Kyotani, H. Nishihara, J. Mater. Chem. A 2021, 9, 14296-14308. [3] K. Nomura, H. Nishihara, M. Yamamoto, A. Gabe, M. Ito, M. Uchimura, Y. Nishina, H. Tanaka, M. T. Miyahara, T. Kyotani, Nat. Commun. 2019, 10, 2559. [4] K. Nomura, H. Nishihara, N. Kobayashi, T. Asada, T. Kyotani, Energy Environ. Sci. 2019, 12, 1542-1549. [5] A. Ohma, Y. Furuya, T. Mashio, M. Ito, K. Nomura, T. Nagao, H. Nishihara, H. Jinnai, T. Kyotani, Electrochim. Acta 2021, 370, 137705.
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Bourgin, Caroline, Roland P. Bourette, Sylvie Arnaud, Yan Liu, Larry R. Rohrschneider, and Guy Mouchiroud. "Induced Expression and Association of the Mona/Gads Adapter and Gab3 Scaffolding Protein during Monocyte/Macrophage Differentiation." Molecular and Cellular Biology 22, no. 11 (June 1, 2002): 3744–56. http://dx.doi.org/10.1128/mcb.22.11.3744-3756.2002.
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ABSTRACT Mona/Gads is a Grb2-related, Src homology 3 (SH3) and SH2 domain-containing adapter protein whose expression is restricted to cells of hematopoietic lineage (i.e., monocytes and T lymphocytes). During monocyte/macrophage differentiation, Mona is induced and interacts with the macrophage colony-stimulating factor receptor, M-CSFR (also called Fms), suggesting that Mona could be involved in developmental signaling downstream of the M-CSFR by recruiting additional signaling proteins to the activated receptor. Our present results identify Mona as a specific partner protein for the DOS/Gab family member Gab3 in monocytic/macrophage development. Mona does not interact with Gab2; however, Gab3 also forms a complex with the Mona-related adapter Grb2. Glutathione S-transferase pull-down experiments demonstrate that the Mona and Gab3 interaction utilizes the carboxy-terminal SH3 domain of Mona and the atypical proline-rich domain of Gab3. Mona is known to interact with the phosphorylated Y697 site of the M-CSFR. The M-CSFR mutation Y697F exhibited qualitative and quantitative abnormalities in receptor and Gab3 tyrosine phosphorylation, and Mona induction was greatly reduced. The Y807F M-CSFR mutation is defective in differentiation signaling, but not growth signaling, and also fails to induce Mona protein expression. During M-CSF-stimulated macrophage differentiation of mouse bone marrow cells, Mona and Gab3 expression is coinduced, these proteins interact, and Mona engages in multimolecular complexes. These data suggest that association of Mona and Gab3 plays a specific role in mediating the M-CSFR differentiation signal.
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Hoppe, B. "Urolithiasis und Nephrokalzinose." Kinder- und Jugendmedizin 13, no. 06 (2013): 424–31. http://dx.doi.org/10.1055/s-0038-1629362.
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ZusammenfassungDie Prävalenz der Nephrokalzinose und Urolithiasis ist in den letzten Jahren auch bei Kindern und Jugendlichen analog dem Verlauf bei Erwachsenen angestiegen. Bei den meisten Kindern und Jugendlichen findet sich ein metabolischer Hintergrund oder eine angeborene Erkrankung als Ursache und demzufolge ist eine ausführliche Diagnostik schon beim ersten Stein unbedingt notwendig. Man sollte auch bedenken, dass weder Stein noch Nephrokalzinose die Erkrankung selber darstellen, sie sind meist ihr erstes Symptom. Die Hyperkalziurie ist der häufigste Risikofaktor für Kristallretention im Nierentubulus und damit der Steinentstehung. Jedoch finden sich weitere metabolische Risikofaktoren wie die Hypozitraturie oder die Hyperoxalurie sowie eine Vielzahl tubulärer Erkrankungen, wie z. B. die renal tubuläre Azidose oder der M. Bartter, die zu Kalzifikationen führen. Assoziierte Symptome, wie z. B. Wachstumsretardierung, intestinale Mal-absorption oder Knochendemineralisation müssen bedacht und evaluiert werden, um Sekundärprobleme zu vermeiden. Frühgeborene stellen eine besondere Risikopopulation dar, dies aufbauend auf immaturem Nierengewebe, Medikation und vor allem Hypozitraturie. Neu diagnostizierte genetische Erkrankungen, die z. B. zur erhöhten Vitamin-D-Sensitivität und damit zu Hyperkalzämie und -iurie führen, müssen hier auch Erwähnung finden. Natürlich ist es unbedingt notwendig, eine möglichst frühzeitige Diagnose zu stellen, um prompt eine adäquate Therapie beginnen zu können. Nur so können rezidivierende Nierensteine oder eine progrediente Nephrokalzinose verhindert werden. Die Behandlung sollte 1. die Urinlöslichkeit per Hyperhydratation (>1,5–2 L pro 1,73m2 Körperoberfläche Flüssigkeitszufuhr) verbessern und 2. Kristallisationsprozesse z. B. durch die Gabe von Alkalizitrat reduzieren. Zusätzlich sind weitere auf die zugrunde liegende Erkrankung bezogene therapeutische Interventionen, z. B. Hydrochlorothiazid bei schwerer Hyperkalziurie, Vita-min-B6-Therapie bei primärer Hyperoxalurie Typ I, indiziert.
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Carpenter, Chris. "Water-Based Drilling Fluid Helps Control Extreme Conditions in Gas Shale Play." Journal of Petroleum Technology 74, no. 11 (November 1, 2022): 62–64. http://dx.doi.org/10.2118/1122-0062-jpt.
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_ This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper URTeC 208307, “A Water-Based Drilling Fluid for Controlling Deep-Reservoir Extreme Conditions in an Abu Dhabi Gas Shale Play,” by Gabe Manescu, SPE, Schlumberger; Balazs Veer, SPE, TotalEnergies; and Panamarathupalayam Balakrishnan, SPE, Schlumberger, et al. The paper has not been peer reviewed. _ A combination of teamwork and fluids technology proved to be the formula for successfully drilling in high-pressure/high-temperature (HP/HT) conditions for an onshore UAE shale gas play. The success achieved in drilling deep [6200-m measured depth (MD)], long-lateral-displacement (2,000-m) wells with an integrated global operator is a combination dependent on frequent, transparent communication between team members. The environmentally acceptable aqueous drilling fluid delivered a barite sag-free operation in these highly deviated wellbores. Introduction The drilling of unconventional HP/HT wells in the Diyab field can experience difficulty in reaching target depth. One significant challenge is the design of a drilling fluid to manage reservoir pressures and temperatures. The reservoir temperature may reach 165.5°C, requiring mud weights (MW) greater than 20 lbm/gal. Tailoring the drilling-fluid formulation to balance economics and environmental regulations while overcoming HP/HT conditions is critical. In the Diyab drilling campaign, special emphasis was placed on designing the drilling fluid and then on its use in 8½-in. reservoir sections. Background The Upper Jurassic (Oxfordian to Middle Kimmeridgian) Diyab formation, also known as the Dukhan formation, has served as the source rock for several major oil and gas fields in the Middle East. The Diyab formation is unique because of its lower porosities, high carbonate mineralogy, and pressure gradient. Despite the lower porosity, the high-carbonate content defines an extremely brittle target conducive to hydraulic fracture stimulation. Several organic-rich intervals exist throughout the Diyab formation and are separated by less-organic tight limestones, which create different flow units. From a developmental perspective, this condition has the potential to create a high-impact stacked play. The extent of the prospective unconventional Diyab formation within the UAE is limited to the onshore north-central UAE, where most of this area is within Block 1, operated by TotalEnergies. The depth of the prospective basal Diyab interval across Block 1 ranges between 3758 and 4115 m. Three unconventional offset wells (DE-02, DE-03, and DE-04) were drilled by ADNOC within Block 1 to test the productivity of the three submembers of the greater Diyab interval (the Jubaila, Hanifa, and Tuwaiq Mountain formations). After determining that the Hanifa formation had the most-promising productivity, the first TotalEnergies appraisal horizontal well, DE-05, was drilled. After drilling this well, the DE-06 well was the second horizontal appraisal well to be drilled. Additionally, two more deep wells, DE-09 and DE-10, were successfully drilled and evaluated.
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Liu, Yan, Brendan Jenkins, Jung Lim Shin, and Larry R. Rohrschneider. "Scaffolding Protein Gab2 Mediates Differentiation Signaling Downstream of Fms Receptor Tyrosine Kinase." Molecular and Cellular Biology 21, no. 9 (May 1, 2001): 3047–56. http://dx.doi.org/10.1128/mcb.21.9.3047-3056.2001.
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ABSTRACT Fms is the receptor for macrophage colony-stimulating factor (M-CSF) and contains intrinsic tyrosine kinase activity. Expression of exogenous Fms in a murine myeloid progenitor cell line, FDC-P1 (FD-Fms), results in M-CSF-dependent growth and macrophage differentiation. Previously, we described a 100-kDa protein that was tyrosine phosphorylated upon M-CSF stimulation of FD-Fms cells. In this report, we identify this 100-kDa protein as the recently cloned scaffolding protein Gab2, and we demonstrate that Gab2 associates with several molecules involved in M-CSF signaling, including Grb2, SHP2, the p85 subunit of phosphatidylinositol 3′-kinase, SHIP, and SHC. Tyrosine phosphorylation of Gab2 in response to M-CSF requires the kinase activity of Fms, but not that of Src. Overexpression of Gab2 in FD-Fms cells enhanced both mitogen-activated protein kinase (MAPK) activity and macrophage differentiation, but reduced proliferation, in response to M-CSF. In contrast, a mutant of Gab2 that is unable to bind SHP2 did not potentiate MAPK activity. Furthermore, overexpression of this mutant in FD-Fms cells inhibited macrophage differentiation and resulted in a concomitant increase in growth potential in response to M-CSF. These data indicate that Gab2 is involved in the activation of the MAPK pathway and that the interaction between Gab2 and SHP2 is essential for the differentiation signal triggered by M-CSF.
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Tsai, L. H., K. Taniyama, and C. Tanaka. "gamma-Aminobutyric acid stimulates acid secretion from the isolated guinea pig stomach." American Journal of Physiology-Gastrointestinal and Liver Physiology 253, no. 5 (November 1, 1987): G601—G606. http://dx.doi.org/10.1152/ajpgi.1987.253.5.g601.
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gamma-Aminobutyric acid (GABA) content was measured, and the effect of GABA on acid secretion was studied using the everted preparation of isolated guinea pig stomachs. GABA contents in the mucosa layer and the remaining layer were 20-24 nmol/g tissue and 34-42 nmol/g tissue, respectively. GABA at 10(-6) to 3 X 10(-5) M induced acid secretion, and the maximum secretion was obtained at 3 X 10(-5) M, that is approximately 1.6-fold of the spontaneous secretion and approximately half of the amount secreted by histamine at 3 X 10(-4) M. The GABA-induced acid secretion was inhibited by bicuculline, scopolamine, pirenzepine, proglumide, and tetrodotoxin, but not by cimetidine. Muscimol (3 X 10 to 10(-5) M), but not baclofen, induced acid secretion in a concentration-dependent manner. The responses to GABA and muscimol were antagonized by bicuculline. Scopolamine and tetrodotoxin completely inhibited the acid secretion induced by low concentrations of GABA and muscimol and to some extent the response induced by high concentrations of muscimol. All these results indicate that GABA induces acid secretion via the A type of GABA receptor, probably located mainly on the cholinergic neurons and partially on the nonneuronal cells in the guinea pig stomach.
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Cooper, Jeffrey B. "An Interview with David M. Gaba." Joint Commission Journal on Quality and Patient Safety 47, no. 8 (August 2021): 463–68. http://dx.doi.org/10.1016/j.jcjq.2021.04.007.
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van der Voort, Anna, Mette S. van Ramshorst, Rob Kessels, Ingrid A. Mandjes, Inge Kemper, Mariëtte J. Agterof, Wim A. van der Steeg, et al. "Abstract PD18-06: Image-guided optimization of neoadjuvant chemotherapy duration in stage II and III HER2-positive breast cancer: radiologic and pathologic complete response (pCR) rates in the multicenter phase 2 TRAIN-3 study (BOOG 2018-01)." Cancer Research 83, no. 5_Supplement (March 1, 2023): PD18–06—PD18–06. http://dx.doi.org/10.1158/1538-7445.sabcs22-pd18-06.
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Abstract Background pCR rates in stage II – III HER2-positive breast cancer have greatly improved since the addition of HER2 targeted agents to neoadjuvant chemotherapy and are associated with excellent long-term survival. While longer treatment regimens increase pCR rate, early complete responses are also common. We evaluated an image-guided approach to tailor chemotherapy duration based on the identification of early complete responders. Methods 45 hospitals across the Netherlands participated in the phase 2 TRAIN-3 trial. Patients received neoadjuvant systemic treatment consisting of paclitaxel, trastuzumab, carboplatin and pertuzumab (PTC-Ptz). Response to treatment was monitored every three cycles and patients were referred for surgery in case of a radiologic complete response (rCR) or after a maximum of 9 cycles. RCR was defined as the absence of pathological enhancement on MRI breast plus negative vacuum assisted core biopsies in case of hormone-receptor positive (HR+) tumors. In addition, negative fine needle aspiration or lymph node biopsy was required in patients with nodal involvement at baseline. The primary endpoint was 3-year event-free survival (EFS). Here, we report locally assessed rCR and pCR rates after 3, 6 and 9 cycles, the negative predictive value of rCR assessment and the incidence of adverse events (AEs). Analyses are stratified by HR-status. Results We included 467 patients between April 2019 and May 2021. Median age was 51 years, 69% had stage II disease and 232 had HR+ tumors. 33.6% of HR- patients and 15.5% of HR+ patients achieved pCR after 3 cycles of PTC-Ptz (see table). The NPV was higher in HR- patients and independent of the number of cycles. AE evaluation is currently ongoing. Conclusion Three cycles of PTC-Ptz induce an early pCR in one in three HR- and one in six HR+ tumors in patients with stage II-III HER2+ breast cancer. Dynamic contrast enhanced MRI-based response evaluation identifies these patients with ±87% certainty in HR- disease and ±58% in HR+ disease. Continuation of PTC-Ptz after 6 cycles further improves pCR rates and can be considered to reduce the need for adjuvant T-DM1. Efficacy and safety of this image-guided approach to tailor treatment duration need to be confirmed with follow-up in EFS and OS analyses. Table 1: Cumulative rCR & pCR according to HR-status *Including patients who underwent surgery for other reasons than rCR Citation Format: Anna van der Voort, Mette S. van Ramshorst, Rob Kessels, Ingrid A. Mandjes, Inge Kemper, Mariëtte J. Agterof, Wim A. van der Steeg, Joan B. Heijns, Marlies L. van Bekkum, Ester J. Siemerink, Philomeen M. Kuijer, Astrid Scholten, Jelle Wesseling, Marie-Jeanne T.F.D. Vrancken Peeters, Ritse M. Mann, Gabe S. Sonke. Image-guided optimization of neoadjuvant chemotherapy duration in stage II and III HER2-positive breast cancer: radiologic and pathologic complete response (pCR) rates in the multicenter phase 2 TRAIN-3 study (BOOG 2018-01) [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr PD18-06.
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Brock, Gareth. "Catheter-related bloodstream infections and dental treatmentLee AM, Gabe SM, Nightingale JM, Burke M (2012) Oral health, dental prophylaxis and catheter related bloodstream infections in home parenteral nutrition patients: results of a UK survey and cohort study. Br Dent J 212 (2): E4." Dental Nursing 8, no. 6 (June 2012): 338–39. http://dx.doi.org/10.12968/denn.2012.8.6.338.
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Shimura, M., N. Harata, M. Tamai, and N. Akaike. "Allosteric modulation of GABAA receptors in acutely dissociated neurons of the suprachiasmatic nucleus." American Journal of Physiology-Cell Physiology 270, no. 6 (June 1, 1996): C1726—C1734. http://dx.doi.org/10.1152/ajpcell.1996.270.6.c1726.
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The gamma-aminobutyric acid (GABA)-induced response was investigated in acutely dissociated suprachiasmatic nucleus (SCN) neurons of 11- to 14-day-old rats, under the voltage-clamp condition of nystatin-perforated patch recording. At a holding potential of -40 mV, application of GABA induced inward currents in a concentration-dependent manner. Pentobarbital and 5 beta-pregnan-3 alpha-ol-20-one (pregnanolone) similarly induced inward currents. GABA-induced inward currents were suppressed in a concentration-dependent manner by pretreating neurons with a GABAA receptor antagonist, bicuculline. Bicuculline (3 x 10(-6) M) shifted the concentration-response curve of GABA to the left in a competitive manner. Reversal potential of the GABA response (EGABA) was -3.4 +/- 0.7 mV, close to the theoretical Cl- equilibrium potential of -4.1 mV. Pretreating SCN neurons with diazepam, pentobarbital, and pregnanolone enhanced the 3 x 10(-6) M GABA response. Diazepam (3 x 10(-8) M), pentobarbital (3 x 10(-5) M), and pregnanolone (10(-7) M) shifted the concentration-response curve of GABA to the left without changing the maximal amplitude of GABA responses. EGABA in the presence of diazepam, pentobarbital, or pregnanolone was the same as that in their absence. These results show that the GABA response in acutely dissociated SCN neurons is mediated by the GABAA receptor. Because the GABAA receptor of SCN neurons is allosterically augmented by diazepam, pentobarbital, and pregnanolone, similarly as in other regions of the central nervous system, the present study opens up ways to functionally modulate the GABAA receptors in SCN.
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van Geel, Jasper JL, Gonneke van der Schoor, Elise van Leeuwen-Stok, John WM Martens, Saskia M. Wilting, Jelle Wesseling, Gabe S. Sonke, and Carolien P. Schröder. "Abstract P1-24-03: Clinicopathological characterization of inflammatory breast cancer in the Netherlands: First results of the prospective INFLAME registry." Cancer Research 82, no. 4_Supplement (February 15, 2022): P1–24–03—P1–24–03. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-24-03.
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Abstract Introduction: Inflammatory breast cancer (IBC) is a rare (<1%) and aggressive subgroup of breast cancer (BC), presenting in relatively young patients. Rapid onset of signs and symptoms, challenging diagnosis and delayed treatment contribute to poor outcome. IBC itself is an independent adverse prognostic factor, but IBC-specific targets for therapy are not available. The prospective Dutch INFLAME registry was set up to improve (molecular) IBC insights, increase awareness, improve diagnostic and treatment protocols in national guidelines, ultimately to improve outcome in IBC. Here, we report baseline clinicopathological- and treatment data from INFLAME. Methods: INFLAME was set up through the Dutch breast oncology research network BOOG. Access to the INFLAME PI team, in light of diagnostic challenges in IBC, was ensured by a study email address and phone number. Patients identified with IBC were included locally in participating hospitals. At baseline, clinical data, blood and if available tumor tissue for molecular analysis was collected. Tissue was also sampled at surgery after preoperative systemic therapy, if applicable. Follow up clinical data were collected after 6 months, 1, 2, and 3 years. Results: From Feb 2015 to Dec 2018, 125 IBC patients were enrolled in 43 hospitals, with a good geographic spread throughout the Netherlands. Patients from non-participating hospitals were referred to participating hospitals. Baseline clinical data was available for 122 patients. Median age was 56.7 years. Median interval between symptoms and diagnosis was 34 days, and 84 (68.9%) patients were diagnosed within three months. Among patients with known M status (n=112), 37 (30.3%) had metastatic disease of which 21 (56.8%) had visceral disease. Of 74 patients without distant disease and N status known, 59 (78.7%) had node positive disease. Baseline tissue was available for pathology assessment in 122 patients. Tumors expressed ER, PR or HER2 in 63, 47 and 41 of cases (51.6, 38.5 and 33.6% respectively). Intrinsic subtype distribution showed hormone receptor (HR)+/HER-, HR+/HER2+, HR-/HER2+ or HR-/HER2- subtype in 47, 17, 24 and 31 of cases (38.5, 13.9, 19.7 and 25.4% respectively). Subtype was unknown in 3 cases (2.5%). The vast majority of patients (n=103, 84.4%) received (anthracyclin and taxane based) chemotherapy. Median interval between diagnosis and start was 19 days and 32 (26,2%) patients started within 2 weeks. HER2. targeting was started in 38 patients (92.7%) with HER2+ IBC. Chemotherapy was followed by surgery in 72 patients, 11 of whom had M+ disease. 41 patients were not operated upon, mostly because of progression. In 70 patients, surgery was followed by locoregional radiotherapy. Endocrine therapy was started in 62 (98.4%) patients with ER+ IBC. Awareness was supported with information material, patient advocate involvement, (inter)national presentations, papers for general practitioners, and the first Dutch IBC guideline. Ongoing consultations of the INFLAME team (by patients, general practitioners, and oncology professionals) reflect this awareness. Conclusions: the INFLAME effort shows feasibility to raise awareness and set up a nationwide prospective registry in a very rare disease such as IBC, despite diagnostic challenges. The registry was accessible, with good Dutch coverage of participating hospitals, referrals, BOOG support, consultations, all supporting inclusion of most IBC patients. Nonetheless, the incidence was very low: <0.25% of the yearly Dutch breast cancer incidence. Further assessments of the INFLAME cohort will focus on molecular tissue assessment, and outcome. The extreme rarity of the disease and its dismal outcome support future joint international efforts for IBC specific intervention studies. Funding: Dutch Cancer Society grant RUG 2013-6267 Citation Format: Jasper JL van Geel, Gonneke van der Schoor, Elise van Leeuwen-Stok, John WM Martens, Saskia M Wilting, Jelle Wesseling, Gabe S Sonke, Carolien P Schröder. Clinicopathological characterization of inflammatory breast cancer in the Netherlands: First results of the prospective INFLAME registry [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-24-03.
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Shirakawa, J., K. Taniyama, S. Iwai, and C. Tanaka. "Regulation of [3H]GABA release from strips of guinea pig urinary bladder." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 255, no. 6 (December 1, 1988): R888—R893. http://dx.doi.org/10.1152/ajpregu.1988.255.6.r888.
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The presence of receptors that regulate the release of gamma-aminobutyric acid (GABA) was studied in strips of the guinea pig urinary bladder. GABA (10(-8)-10(-5) M) and muscimol (10(-8)-10(-5) M), but not baclofen (10(-5) M), reduced the Ca2+-dependent, tetrodotoxin-resistant release of [3H]GABA evoked by high K+ from the urinary bladder strips preloaded with [3H]GABA. The inhibitory effect of muscimol was antagonized by bicuculline and potentiated by diazepam, clonazepam, and pentobarbital sodium. The potentiating effect of clonazepam was antagonized by Ro 15-1788. Acetylcholine (ACh) inhibited the high K+-evoked release of [3H]GABA. The inhibitory effect of ACh was antagonized by atropine sulfate and pirenzepine but not by hexamethonium. Norepinephrine (NE) inhibited the evoked release of [3H]GABA. The inhibitory effect of NE was mimicked by clonidine, but not by phenylephrine, and was antagonized by yohimbine but not by prazosin. These results provide evidence that the release of GABA from strips of guinea pig urinary bladder is regulated via the bicuculline-sensitive GABAA receptor, M1-muscarinic, and alpha 2-adrenergic receptors.
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Li, Wen, Mingming Wei, Junjun Wu, Xin Rui, and Mingsheng Dong. "Novel fermented chickpea milk with enhanced level ofγ-aminobutyric acid and neuroprotective effect on PC12 cells." PeerJ 4 (August 4, 2016): e2292. http://dx.doi.org/10.7717/peerj.2292.
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In this study, novel fermented chickpea milk with highγ-aminobutyric acid (GABA) content and potential neuroprotective activity was developed. Fermentation starter that can produce GABA was selected from 377 strains of lactic acid bacteria isolated from traditional Chinese fermented foods. Among the screened strains, strain M-6 showed the highest GABA-producing capacity in De Man–Rogosa and Sharp (MRS) broth and chickpea milk. M-6 was identified asLactobacillus plantarumbased on Gram staining, API carbohydrate fermentation pattern testing, and 16s rDNA sequencing. The complete gene encoding glutamate decarboxylase was cloned to confirm the presence of the gene inL. plantarumM-6. The fermentation condition was optimized by response surface methodology. Results demonstrated thatL. plantarumM-6 produced the highest GABA content of 537.23 mg/L. The optimal condition included an inoculum concentration of 7%, presence of 0.2% (m/v) monosodium glutamate and 55 µ M pyridoxal-5-phosphate, incubation temperature of 39 °C and fermentation time of 48 h . GABA-enriched chickpea milk exerted protective effects on PC12 cells against MnCl2-induced injury. GABA-enriched chickpea milk improved cell viability and markedly attenuated the release of lactate dehydrogenase compared with the impaired cells.
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Lückermann, Mark, Stefan Trapp, and Klaus Ballanyi. "GABA- and Glycine-Mediated Fall of Intracellular pH in Rat Medullary Neurons In Situ." Journal of Neurophysiology 77, no. 4 (April 1, 1997): 1844–52. http://dx.doi.org/10.1152/jn.1997.77.4.1844.
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Lückermann, Mark, Stefan Trapp, and Klaus Ballanyi. GABA- and glycine-mediated fall of intracellular pH in rat medullary neurons in situ. J. Neurophysiol. 77: 1844–1852, 1997. In the region of the ventral respiratory group in brain stem slices from neonatal rats, intracellular pH (pHi) and membrane currents ( I m) or potentials were measured in neurons dialyzed with the pH-sensitive dye 2′,7′-bis-carboxyethyl-5(6)-carboxyfluorescein. Currents and increases in membrane conductance ( g m) during bath application of 0.1 or 1 mM γ-aminobutyric acid (GABA) were accompanied by a delayed mean fall of pHi by 0.17 and 0.25 pH units, respectively, from a pHi baseline of 7.33. These effects were reversibly suppressed by 50–100 μM bicuculline. Similar effects on I m, g m, and pHi were revealed on administration of 0.1 or 1 mM glycine. These responses were abolished by 10–100 μM strychnine. Dialysis of the cells with 15–30 μM carbonic anhydrase led to an acceleration of the kinetics and a potentiation of the GABA-induced pHi decrease. GABA- and glycine-evoked pHi decreases were very similar during recordings with either high- or low-Cl− patch electrodes, although the reversal potential of the accompanying currents differed by ∼60 mV. The GABA-induced pHi decrease, but not the accompanying I m and g m responses, was suppressed in CO2/HCO− 3-free, N-2-hydroxy-ethylpiperazine- N′-2-ethane sulphonic acid pH-buffered solution. Depolarization from −60 to +30 mV resulted in a sustained fall of pHi by maximally 0.5 pH units. In this situation, the GABA-induced fall of pHi turned into an intracellular alkalosis of 0.09–0.15 pH units. The results confirm and extend previous findings obtained in vivo that GABA- or glycine-induced intracellular acidosis of respiratory neurons is due to efflux of HCO− 3 via the receptor-coupled Cl− channel.
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Hunt, Robert. "Perfection Makes Practice - By Anna M. Gade." Muslim World 98, no. 1 (January 21, 2008): 147–49. http://dx.doi.org/10.1111/j.1478-1913.2008.214_2.x.
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Veksler, A. Z., S. V. Gagaev, A. M. Shanaurin, and V. E. Shcherbinin. "An M-503 magnetic-field strength gage." Russian Journal of Nondestructive Testing 40, no. 11 (November 2004): 776–81. http://dx.doi.org/10.1007/s11181-005-0057-1.
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Mantz, Jean, Jean-Baptiste Lecharny, Vincent Laudenbach, Danielle Henzel, Gilles Peytavin, and Jean-Marie Desmonts. "Anesthetics Affect the Uptake but Not the Depolarization-evoked Release of GABA in Rat Striatal Synaptosomes." Anesthesiology 82, no. 2 (February 1, 1995): 502–11. http://dx.doi.org/10.1097/00000542-199502000-00020.
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Background Numerous classes of anesthetic agents have been shown to enhance the effects mediated by the postsynaptic gamma-aminobutyric acid A (GABAA) receptor-coupled chloride channel in the mammalian central nervous system. However, presynaptic actions of anesthetics potentially relevant to clinical anesthesia remain to be clarified. Therefore, in this study, the effects of intravenous and volatile anesthetics on both the uptake and the depolarization-evoked release of GABA in the rat striatum were investigated. Methods Assay for specific GABA uptake was performed by measuring the radioactivity incorporated in purified striatal synaptosomes incubated with 3H-GABA (20 nM, 5 min, 37 degrees C) and increasing concentrations of anesthetics in either the presence or the absence of nipecotic acid (1 mM, a specific GABA uptake inhibitor). Assay for GABA release consisted of superfusing 3H-GABA preloaded synaptosomes with artificial cerebrospinal fluid (0.5 ml.min-1, 37 degrees C) and measuring the radioactivity obtained from 0.5 ml fractions over 18 min, first in the absence of any treatment (spontaneous release, 8 min), then in the presence of either KCl alone (9 mM, 15 mM) or with various concentrations of anesthetics (5 min), and finally, with no pharmacologic stimulation (5 min). The following anesthetic agents were tested: propofol, etomidate, thiopental, ketamine, halothane, enflurane, isoflurane, and clonidine. Results More than 95% of 3H-GABA uptake was blocked by a 10(-3)-M concentration of nipecotic acid. Propofol, etomidate, thiopental, and ketamine induced a dose-related, reversible, noncompetitive, inhibition of 3H-GABA uptake: IC50 = 4.6 +/- 0.3 x 10(-5) M, 5.8 +/- 0.3 x 10(-5) M, 2.1 +/- 0.4 x 10(-3) M, and 4.9 +/- 0.5 x 10(-4) M for propofol, etomidate, thiopental, and ketamine, respectively. Volatile agents and clonidine had no significant effect, even when used at concentrations greater than those used clinically. KCl application induced a significant, calcium-dependent, concentration-related, increase from basal 3H-GABA release, +34 +/- 10% (P < 0.01) and +61 +/- 13% (P < 0.001), respectively, for 9 mM and 15 mM KCl. The release of 3H-GABA elicited by KCl was not affected by any of the anesthetic agents tested. Conclusions These results indicate that most of the intravenous but not the volatile anesthetics inhibit the specific high-affinity 3H-GABA uptake process in vitro in striatal nerve terminals. However, this action was observed at clinically relevant concentrations only for propofol and etomidate. In contrast, the depolarization-evoked 3H-GABA release was not affected by anesthetics. Together, these data suggest that inhibition of GABA uptake, which results in synaptic GABA accumulation, might contribute to propofol and etomidate anesthesia.
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Jushkin, V. D., L. V. Zotov, and O. A. Khrapenko. "Hydrogeology correction in the gravitational field from satellite data." Geodesy and Cartography 931, no. 1 (February 20, 2018): 2–7. http://dx.doi.org/10.22389/0016-7126-2018-931-1-2-7.
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The results of repeated measurements of the acceleration of gravity by the Russian absolute ballistic field gravimeter GABL-M on points of oil and gas deposits in the permafrost over a five year period are presented. The changes of gravity acceleration by the absolute gravimeter and GRACE satellite were compared. The results of comparisons of differences gravity acceleration by ballistic gravimeter GABL-M and relative Canadian gravimeters CG5 were [i]shown. The errors in determination of parameters of the gravitational field ballistic gravimeter GABL-M and CG5 gravimeters group were presented. The method of measurement with the gravimeter GABL-M and the method of determining the vertical gradients relative CG5 gravity meters was described. The necessity of introducing corrections of hydrogeology is caused by influence of hydro geological factors on the gravitational field in the permafrost. They are comparable with the values of the field change in the result of gas pumping.
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Ong, Jennifer, and David I. B. Kerr. "GABA-receptors in peripheral tissues." Life Sciences 46, no. 21 (January 1990): 1489–501. http://dx.doi.org/10.1016/0024-3205(90)90421-m.
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Curtis, David R. "GABA synapses in the brain." Trends in Neurosciences 18, no. 6 (January 1995): 263. http://dx.doi.org/10.1016/0166-2236(95)80005-m.
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Haugstad, Tor S., and Iver A. Langmoen. "L-α-Aminoadipate Reduces Glutamate Release from Brain Tissue Exposed to Combined Oxygen and Glucose Deprivation." Journal of Cerebral Blood Flow & Metabolism 17, no. 5 (May 1997): 567–70. http://dx.doi.org/10.1097/00004647-199705000-00011.
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The effect of the glutamate analogue L- α-aminoadipate ( αAA) on the release of glutamate and γ-aminobutyric acid (GABA) from rat hippocampal slices was investigated in vitro. Oxygen/glucose deprivation caused a large release of glutamate and GABA. αAA added during energy deprivation reduced the glutamate release in a dose-dependent manner (56% reduction at 5 m M), whereas GABA release was unchanged. We speculate that ischemic glutamate release from the brain is mediated by a low affinity transport mechanism that is blocked by αAA.
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Al-Ayyubi, M. Zia. "Tilawah of the Quran in Anna M. Gade’s View : Philosophical Studies and Its Relevance to the Quranic Sciences." Millati: Journal of Islamic Studies and Humanities 5, no. 1 (June 29, 2020): 65–80. http://dx.doi.org/10.18326/mlt.v5i1.65-80.
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Tulisan ini merupakan ulasan pemikiran salah seorang sarjanawan Barat yang bernama Anna M. Gade tentang tilawah. Anna M. Gade sendiri merupakan seorang profesor pada bidang Studi Lingkungan di Universitas Wisconsin, Madison, Amerika Serikat. Dalam salah satu karyanya, ia spesifik menunjukkan dalam judulnya “The Quran Recitation”, yang berarti tilawah al-Quran. Ketika disebut tilawah al-Quran (bacaan al-Quran), tentu ini terdapat keterkaitan dengan qira’ah al-Quran yang secara bahasa sama-sama menunjukkan arti bacaan al-Quran. Untuk permasalah tersebut, Gade menjelaskan bahwa tilawah merupakan salah satu bagian dari qira’ah, karena cakupan dari qira’ahyang lebih umum dari pada tilawah. Selain itu, Gade juga menjelaskan tilawah pada sisi pendeskripsian al-Quran terhadap tilawah, praktik, keindahan, hingga kompetisi tilawah al-Quran.
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Rohman, Nur. "Anna M. Gade dan MTQ di Indonesia: Sebuah Kajian Metodologis." Al-A'raf : Jurnal Pemikiran Islam dan Filsafat 13, no. 1 (June 5, 2016): 109. http://dx.doi.org/10.22515/ajpif.v13i1.42.
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This article constitutes to repeatedly reading the orientalists research findings on the practice of the holy Qurans reading in Indonesia. It is very important, especially related to the methodology used, because at the same time both of those who are interested to study the holy Quran and the cultural observers see the various daily activities of the people showing the natural phenomenon that can be approached through the social-humanities disciplines. This article explained that Anna M. Gade operated Clifford Geertzs theory on religion as cultural system. Anna Gade said that the practical reading of the Quran (in Indonesia) is constituted by several things, which then grouped into motivation and mood.
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Mehta, Ashok K., and Maharaj K. Ticku. "Chronic GABA exposure down-regulates GABA-benzodiazepine receptor-ionophore complex in cultured cerebral cortical neurons." Molecular Brain Research 16, no. 1-2 (November 1992): 29–36. http://dx.doi.org/10.1016/0169-328x(92)90190-m.
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Roberts, D. J., W. L. Hasler, and C. Owyang. "GABA mediation of the dual effects of somatostatin on guinea pig ileal myenteric cholinergic transmission." American Journal of Physiology-Gastrointestinal and Liver Physiology 264, no. 5 (May 1, 1993): G953—G960. http://dx.doi.org/10.1152/ajpgi.1993.264.5.g953.
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Somatostatin (SS) has both excitatory and inhibitory actions on myenteric cholinergic transmission, which are mimicked by gamma-aminobutyric acid (GABA). We hypothesized that both effects of SS are mediated by neural GABA pathways. In guinea pig ileal longitudinal muscle-myenteric plexus, SS evoked [3H]-GABA release verifying GABA neural activation. SS (10(-9)-10(-5) M) stimulation of atropine-sensitive ileal contraction and evocation of tetrodotoxin-sensitive [3H]acetylcholine (ACh) release was mimicked by the GABAA agonist muscimol but not the GABAB agonist baclofen. SS (10(-7) M)-evoked contraction and [3H]ACh release were markedly reduced by the GABAA antagonist bicuculline (10(-5) M) but not the GABAB antagonist phaclofen. Cholecystokinin (CCK) evokes ileal contraction via an atropine-sensitive pathway and stimulates ACh release via adenylate cyclase activation. SS inhibited contraction and release evoked by CCK (10(-7) M). These inhibitory actions were reversed by phaclofen but not bicuculline and were mimicked by baclofen but not muscimol. Pertussis toxin (200 ng/ml for 3 h) reversed the inhibitory effects of SS and baclofen on CCK-stimulated contraction and release. In conclusion, SS modulates ileal cholinergic pathways by stimulation of GABA neural pathways. The excitatory action of SS is mediated by GABAA receptors, whereas the inhibitory action utilizes GABAB receptors via a pertussis toxin-sensitive G protein.
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Salord, Francois, Hawa Keita, Jean-Baptiste Lecharny, Danielle Henzel, Jean-Marie Desmonts, and Jean Mantz. "Halothane and Isoflurane Differentially Affect the Regulation of Dopamine and Gamma-aminobutyric Acid Release Mediated by Presynaptic Acetylcholine Receptors in the Rat Striatum." Anesthesiology 86, no. 3 (March 1, 1997): 632–41. http://dx.doi.org/10.1097/00000542-199703000-00016.
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Background General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junction, little is known about their actions on the acetylcholine receptors in the CNS. In this study, the effects of halothane and isoflurane on the regulation of dopamine (DA) (gamma-aminobutyric acid [GABA]) depolarization-evoked release mediated by nicotinic (muscarinic) presynaptic receptors were studied in the rat striatum. Methods Assay for GABA (dopamine) release consisted of 3H-GABA (3H-DA)-preloaded synaptosomes with artificial cerebrospinal fluid (0.5 ml/min, 37 degrees C) and measuring the radioactivity obtained from 1-min fractions for 18 min, first in the absence of any treatment (spontaneous release, 8 min), then in the presence of depolarizing agents combined with vaporized halothane and isoflurane (0.5-5%, 5 min), and finally with no pharmacologic stimulation (5 min). The depolarizing agents were potassium chloride (KCl; 9 mM) alone or with acetylcholine (10(-6)-10(-4) M) and/or atropine (10(-5) M) for experiments with 3H-GABA, and KC1 (15 mM) and nicotine (10(-7) - 5 x 10(-4) M) alone or with mecamylamine (10(-5) M) for experiments with 3H-DA. Results Potassium chloride induced a significant, Ca(2+)-dependent release of both 3H-GABA and 3H-DA. Nicotine produced a concentration-related, mecamylamine-sensitive 3H-DA release that was significantly attenuated by nicotine (10(-7) M) preincubation. Acetylcholine elicited a dose-dependent, atropine-sensitive reduction of the KC1-evoked 3H-GABA release. Halothane and isoflurane significantly decreased the nicotine-evoked 3H-DA release but had only limited depressant effects on the KC1-stimulated 3H-DA and no action on the KC1-induced 3H-GABA release. The effects of acetylcholine on 3H-GABA release were reversed by halothane but not by isoflurane. Conclusions Clinically relevant concentrations of halothane and isoflurane significantly, but differentially, alter the presynaptic cholinergic regulation of the release of inhibitory neurotransmitters in the striatum. These results suggest that the cholinergic transmission may represent an important and specific presynaptic target for volatile anesthetics in the CNS.
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Jovanović, Davor, and Aleksandar Nešović. "Optimal orientation of the gable roofs covered with photovoltaic panels: Case study Kragujevac." Tehnika 78, no. 3 (2023): 319–23. http://dx.doi.org/10.5937/tehnika2303319j.
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In this paper, a study was conducted to determine the optimal orientation of the gable roofs covered with photovoltaic panels (PVP) for the area of the city of Kragujevac. Numerical simulations using Google SketchUp and EnergyPlus software are performed for two different PVP placement cases. The first case analyzes the installation of PVP only on one side of the gable roof. The second case analyzes the installation of PVP on both sides of the gable roof. The weather conditions for the city of Kragujevac were taken into account during the simulations. In the case of one-sided gable roof covering, the annual electricity production is the highest when the PVPs are facing south (223.26 kWh/m 2 /a). In the case of bilateral (two-sided) covering, the annual electricity production can be up to 181.3 kWh/m 2 /a, if the gable roof is oriented in the East-West direction. By comparing both cases, south-oriented PVPs from the first case annually generate 18.79% more electricity than East-West-oriented PVPs from the second case.
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Maynard, Alan. "Going Private: Why People Pay for their Health Care by M. Calnan, S. Cant and J. Gabe. Open University Press, 1993. No. of pages: 113. ISBN 0-335-09980-7. Laing's Review of Private Healthcare, Laing and Buisson, London, 1993. No. of pages: 1252. ISBN 1-85440-030-4." Health Economics 3, no. 2 (March 1994): 130–31. http://dx.doi.org/10.1002/hec.4730030212.
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Verma, P. K., D. Kumar, and S. K. Tandan. "Effects of amino acid neurotransmitters on spontaneous muscular activity of the rumen amphistome, Gastrothylax crumenifer." Journal of Helminthology 83, no. 4 (May 29, 2009): 385–89. http://dx.doi.org/10.1017/s0022149x09389282.
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AbstractAmino acid neurotransmitters play an important role in regulating neuromuscular activity of helminth parasites. The present study aimed to investigate the effects of different amino acid neurotransmitters [l-glutamate, glycine, gamma-aminobutyric acid (GABA)] on spontaneous muscular activity of isometrically mounted Gastrothylax crumenifer. l-Glutamate caused a significant increase in the amplitude and frequency of spontaneous contractions of rumen fluke at 10− 7–10− 4 m and at 10− 5–10− 4 m concentrations, respectively. Glycine application (10− 7–10− 3 m) produced a significant decrease in the amplitude and frequency of spontaneous muscular contractions in a concentration-dependent manner, as compared to control amplitude (0.53 ± 0.02 g) and frequency (51 ± 4.65/5 min). Similarly, GABA produced a significant (P < 0.05) decrease in amplitude, baseline tension and frequency of spontaneous muscular contractions of G. crumenifer. To further substantiate the GABA effect, GABAA receptor antagonists, picrotoxin and bicuculline were applied. Picrotoxin (10− 5–10− 3 m) caused a significant (P < 0.05) increase in amplitude, baseline tension and frequency of the rumen fluke as compared to control; whereas bicuculline did not elicit any observable effect in these attributes in isometrically mounted rumen flukes. These observations suggested that l-glutamate has an excitatory, whereas GABA and glycine have an inhibitory, effect on the spontaneous muscular activity of G. crumenifer.
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Michalik, Mariusz, and Maria Erecińska. "Gaba in pancreatic islets: Metabolism and function." Biochemical Pharmacology 44, no. 1 (July 1992): 1–9. http://dx.doi.org/10.1016/0006-2952(92)90030-m.
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Liefaard, Marte C., Anna van der Voort, Joyce Sanders, Shiva Vonk, Hugo M. Horlings, Sabine Siesling, Linda de Munck, et al. "Abstract PD15-07: Effect of pertuzumab plus neoadjuvant trastuzumab-based chemotherapy in early-stage HER2-positive breast cancer according to BluePrint molecularly defined breast cancer subtypes." Cancer Research 82, no. 4_Supplement (February 15, 2022): PD15–07—PD15–07. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd15-07.
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Abstract Background: The addition of pertuzumab to neoadjuvant trastuzumab-containing chemotherapy significantly improves pathological complete response (pCR) rates in patients with HER2-positive breast cancer. However, effects on long-term survival outcomes have been modest. While prior studies suggest that only a subset of patients benefits most from the addition of pertuzumab, a reliable biomarker for response prediction has not been established. BluePrint is an 80-gene molecular subtyping test that classifies breast tumors as Basal-, Luminal- or HER2-subtype. Recent data shows that some tumors have more than one activated pathway and can be classified as dual subtype. Secondary analyses from the Aphinity trial (NCT01358877) suggest that pertuzumab benefit is largely restricted to patients with single-activated HER2-type tumors and less pronounced in patients with other single- or dual-activated subtypes. In this study, we evaluated BluePrint subtype as a biomarker for predicting response to trastuzumab-containing neoadjuvant chemotherapy with or without pertuzumab in a large nationwide cohort of patients. Methods: We collected data of all patients with stage II-III HER2-positive breast cancer who received neoadjuvant chemotherapy and trastuzumab between January 2013 and January 2016 from the Netherlands Cancer Registry. Pertuzumab was not reimbursed in the Netherlands during this period but was available to patients participating in the TRAIN2 clinical trial (NCT01996267). Pre-treatment biopsies were collected and tumor cell percentage was adequate in 404 patients who received pertuzumab and in 432 matched control patients who did not receive pertuzumab. Matching factors included treatment with anthracyclines (yes vs. no), age and hormone receptor status. BluePrint molecular subtypes were determined sucessfully through microarray in 680 patients. Pathological complete response (pCR) and overall survival (OS) were analyzed by treatment arm and BluePrint subtypes, using logistic and Cox regression analyses. Results: Microarray data was available for 334 patients who received pertuzumab and 346 patients who did not. Tumors were classified as single HER2 (77.6%), Luminal-HER2 (11.3%), single Luminal (8.4%), or other (2.6%). Overall, pCR rate was 65.0% in patients who received pertuzumab and 38.9% in patients who did not. In patients with single HER2-type tumors, pCR rate was significantly higher with pertuzumab (77.0% vs. 46.0%, multivariate adjusted odds ratio [aOR] 3.92, 95% confidence interval [CI] 2.60 - 5.98). In patients with other subtypes, pCR rate was lower overall and not significantly different with or without pertuzumab (23.5% vs. 13.5%, aOR 2.50, 95% CI 0.98 - 6.89). In addition, multivariate Cox regression analyses showed a significant OS benefit with pertuzumab in patients with single HER2-type tumors (adjusted hazard ratio [aHR] 0.33, 95% CI 0.16 - 0.67), but not in other subtypes (aHR 0.94, 95% CI 0.31 - 2.83). However, tests for interactions between pertuzumab and BluePrint subtypes were not significant. Conclusion: We confirmed the results of a prior secondary analysis of the Aphinity trial that the benefit of adding pertuzumab to (neo)adjuvant trastuzumab-based chemotherapy seems most pronounced in patients with a molecularly defined single-activated HER2-subtype. In other subtypes, pathological complete response rates and long-term outcomes are worse overall and no clear benefit of pertuzumab was seen, although tests for interaction between pertuzumab treatment and BluePrint subtype were not significant. Citation Format: Marte C Liefaard, Anna van der Voort, Joyce Sanders, Shiva Vonk, Hugo M Horlings, Sabine Siesling, Linda de Munck, Elise van Leeuwen-Stok, Miranda Kleijn, Lorenza Mittempergher, Midas M Kuilman, Esther H Lips, Gabe S Sonke. Effect of pertuzumab plus neoadjuvant trastuzumab-based chemotherapy in early-stage HER2-positive breast cancer according to BluePrint molecularly defined breast cancer subtypes [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD15-07.
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O'Shaughnessy, Joyce, Salomon M. Stemmer, Howard A. Burris, Yoon-Sim Yap, Gabe Sonke, Lowell Hart, Mario Campone, et al. "Abstract GS2-01: Overall survival subgroup analysis by metastatic site from the phase 3 MONALEESA-2 study of first-line ribociclib + letrozole in postmenopausal patients with advanced HR+/HER2− breast cancer." Cancer Research 82, no. 4_Supplement (February 15, 2022): GS2–01—GS2–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs2-01.
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Abstract Background: MONALEESA-2 (ML-2) recently reported a statistically significant overall survival (OS) benefit with first-line ribociclib (RIB) + letrozole (LET) over placebo (PBO) + LET in postmenopausal patients with HR+/HER2- advanced breast cancer (ABC) (median, 63.9 vs 51.4 months; hazard ratio, 0.76; 95% CI, 0.63-0.93; P = .004). Understanding OS outcomes in clinically relevant subgroups of patients is important for improving personalized care and prognosis. Here, we report the results of a prespecified exploratory OS analysis in select patient subgroups by baseline location and number of metastatic sites.. Methods: Postmenopausal patients with HR+/HER2− ABC were randomized 1:1 to receive first-line RIB or PBO with LET. Prespecified exploratory OS analyses were performed for subgroups of special interest by baseline location (bone only [yes or no], liver involvement [yes or no], liver or lung involvement [yes or no]) and number of metastatic sites (< 3 or ≥ 3). The data are hypothesis generating since this analysis was exploratory and not powered for statistical significance.. Results: A total of 668 patients were included in the analysis. A consistent improvement in OS was observed with RIB + LET vs PBO + LET in all subgroups regardless of baseline metastatic site (Table). RIB + LET demonstrated an OS benefit over PBO + LET in clinically relevant subgroups by baseline location and number of metastatic sites, including subgroups of patients with liver metastases, liver or lung metastases, and ≥ 3 metastatic sites, who generally have a worse prognosis.. Conclusion: Consistent with the intent-to-treat population of ML-2, the results of this prespecified exploratory analysis demonstrated an OS benefit with RIB + LET independent of the site and number of metastatic lesions. TableTreatment Arm (n)HR (95% CI)Bone-only metastasisYesRIB + LET (69)0.78 (0.50-1.21)PBO + LET (79)NoRIB + LET (265)0.77(0.61-0.96)PBO + LET (255)Liver involvementYesRIB + LET (59)0.81 (0.54-1.24)PBO + LET (72)NoRIB + LET (275)0.77 (0.62-0.97)PBO + LET (262)Liver or lung involvementYesRIB + LET (182)0.81(0.62-1.05)PBO + LET (190)NoRIB + LET (152)0.71 (0.53-0.96)PBO + LET (144)No. of metastatic sites< 3RIB + LET (220)0.78(0.61-1.00)PBO + LET (222)≥ 3RIB + LET (114)0.71(0.51-0.98)PBO + LET (112) Citation Format: Joyce O'Shaughnessy, Salomon M Stemmer, Howard A Burris, Yoon-Sim Yap, Gabe Sonke, Lowell Hart, Mario Campone, Katarina Petrakova, Eric P Winer, Wolfgang Janni, Pierfranco Conte, David A Cameron, Fabrice André, Carlos Arteaga, Juan Pablo Zarate, Arunava Chakravartty, Tetiana Taran, Fabienne Le Gac, Paolo Serra, Gabriel N Hortobagyi. Overall survival subgroup analysis by metastatic site from the phase 3 MONALEESA-2 study of first-line ribociclib + letrozole in postmenopausal patients with advanced HR+/HER2− breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr GS2-01.