Dissertations / Theses on the topic 'GABAergic'
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Gabor, Ronnie. "GABAergic mechanisms in adrenal enzyme regulation." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63939.
Full textBenini, Ruba Sayed. "GABAergic signalling in temporal lobe epilepsy." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111818.
Full textCobb, Stuart Robert. "Synaptic interaction of hippocampal gabaergic neurones." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:527682b7-2146-458a-b821-5dca9733e32f.
Full textNasrallah, Fatma Faculty of Medicine UNSW. "A metabolic approach to the GABAergic system." Publisher:University of New South Wales, 2008. http://handle.unsw.edu.au/1959.4/43413.
Full textNicholson, Martin William. "Diazepam-dependent modulation of GABAergic inhibitory synapses." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046265/.
Full textMa, Wenqian. "Dlx Gene Regulation of Zebrafish GABAergic Interneuron Development." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19970.
Full textGarden, Derek Leonard Frank. "GABAergic transmission in the perirhinal cortex in vitro." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274770.
Full textHuff, Courtney L. M. S. "MDMA and Glutamate: Implications for Hippocampal GABAergic Neurotoxicity." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444662.
Full textMabey, Jennifer Kei. "Synaptic Plasticity in GABAergic Inhibition of VTA Neurons." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/5256.
Full textCOLACI, FRANCESCO. "GABAergic synaptic protein dynamics measured by spectroscopic approaches." Doctoral thesis, Università degli studi di Genova, 2018. http://hdl.handle.net/11567/929825.
Full textMellor, Jack Robert. "Electrophysiological investigation of the mechanisms underlying GABAergic synaptic transmission." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624122.
Full textBienvenu, Thomas Claude Michel. "Functional specialisation of GABAergic cells in the basolateral amygdala." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d52fb5ad-19cc-41b8-a1e2-2f25ef82dddf.
Full textPallotto, Marta. "GABAergic signaling and synaptic integration of adult-generated neurons." Paris 6, 2012. http://www.theses.fr/2012PA066677.
Full textAdult neurogenesis represents a unique form of brain plasticity. In mammals the genesis of new neurons is mainly restricted to the dentate gyrus of the hippocampus and the olfactory bulbs. In the olfactory bulb (OB), neurons are continuously added to pre-existing networks and differentiate mainly into GABAergic local interneurons: granule cells (GCs) and periglomerular cells (PGCs). These interneurons mature and integrate in the OB network acquiring an adult phenotype. In the present work, I investigated the synaptic integration of adult-generated GCs in the mouse OB. I took advantage of local injections of eGFP encoding lentiviral vector to visualize through GFP fluorscent labelling new-born GCs in the adult OB at different times after their genesis. I found that adult-generated GCs start to receive synaptic contacts as soon as they reach their final destination in the OB. In fact, the first synaptic inputs onto GFP-positive cells were detected in the granule cell layer at 3 days post-injection (dpi). Interestingly, I found that at early stages GABAergic synapses were more abundant than glutamatergic contacts, suggesting that GABA may play an important role in the synaptic integration, maturation and survival of newborn GCs. To verify this hypothesis, I used Cre-mediated conditional deletion of the Gabra2 gene encoding for the 2 subunit of the GABAA receptor (GABAAR) to functionally disrupt afferent GABAergic transmission in migrating GC precursors. Using two different transgenic mouse models, I found that ablation of the 2-subunit was accompanied by a dramatic reduction in the frequency and amplitude of spontaneous or evoked GABAergic IPSCs. Remarkably, this reduced GABAergic activity did not affect GC survival but delayed dramatically their maturation. In mutant cells, dendritic branching and spine density were reduced, and spine loss was accompanied by a mislocation of excitatory synapses from spine heads to dendritic shafts. Moreover, deletion of the 2 subunit occluded structural plasticity of spines inducible by odor-enrichment and odor-deprivation protocols. These results show that proper GABAergic signaling is required for the morphological development and synaptic integration of adult-born GCs, and reveal an unexpected function of early GABAergic inputs in controlling spine formation and glutamatergic synaptogenesis
Mazo, Camille. "GABAergic signaling in cortical feedback to the olfactory bulb." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066066/document.
Full textCortical feedback conducts information towards earlier relays of information processing. It is instrumental for sensory perception. In the olfactory system, odorants are never experienced in isolation by the nose, and they might be meaningful to the animal or not depending on the context. Feedback inputs onto early processing stages are poised to permit selective attention to the relevant odorants in the olfactory scene. During my thesis work, I focused on understanding the key role that inhibitory GABAergic signaling plays in the cortical feedback to the olfactory bulb in mice.The first part of my work started with the discovery of excitatory transmission between cortical feedback inputs and the olfactory bulb is modulated by metabotropic receptors for GABA. Next, the impact of this regulation on the olfactory bulb network was investigated. We found that GABAergic signaling at cortical feedback axons profoundly changes the response of the olfactory bulb output cells to odor stimulation. In the second part of my thesis, I found that the cortical projections to the olfactory bulb not only comprises of excitatory components, but also inhibitory components. The precise origin of this GABAergic feedback was then determined and its impact on the olfactory bulb network is currently assessed. In particular, we observed that manipulating the activity of this GABAergic feedback perturbs olfactory behavior
Verkuyl, Jan Maarten. "Stress, corticosterone and GABAergic inhibition in the rat paraventricular nucleus." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/70710.
Full textFerrigan, Leanne M. "Synaptic interactions between cholinergic and GABAergic systems of the hippocampus." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410010.
Full textBaker, Christian. "Developmental challenge and GABAergic neuronal abnormalities : their relevance to schizophrenia." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274951.
Full textTanaka, Yasuyo. "Local connections of layer 5 GABAergic interneurons to corticospinal neurons." Kyoto University, 2012. http://hdl.handle.net/2433/152493.
Full textUusisaari, Marylka. "GABAergic mechanisms of excitation and hypersynchrony in adult rat hippocampus." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/uusisaari/.
Full textFan, Kai Yoon. "GABAergic synaptic transmission, plasticity and integration in the subthalamic nucleus." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3167/.
Full textCarus-Cadavieco, Marta. "Coordination of innate behaviors by GABAergic cells in lateral hypothalamus." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19135.
Full textLateral hypothalamus (LH) is crucial for regulation of innate behaviors. However, it remained unknown whether and how temporal coordination of hypothalamic neuronal populations regulates behavioral transitions. This work combined optogenetics with neuronal recordings in behaving mice. LHVgat cells were optogenetically identified. LHVgat neurons increased firing rates upon transitions from non-REM (NREM) sleep to wakefulness, and their optogenetic stimulation during NREM sleep induced a fast transition to wakefulness. LHVgat cells project to the reticular thalamic nucleus (RTN). Optogenetic activation of LHVgat terminals in the RTN exerted a strong frequency-dependent inhibition of RTN cells and replicated state-dependent changes in RTN neurons activity. Recordings of LH neurons during exploration revealed that 65% of LH neurons increased their activity upon the onset of locomotion. Top-down forebrain innervation of LH is provided, to a great extent, by inhibitory inputs from the lateral septum (LS). During spontaneous exploration in a free-feeding model, LS and LH displayed prominent gamma oscillations (30-90 Hz) which entrained neuronal activity within and across the two regions. Optogenetic gamma-frequency stimulation of somatostatin-positive GABAergic projections to LH facilitated food-seeking, and increased the probability of entering the food zone. LS inhibitory input enabled separate signaling by LH neurons according to their feeding-related activity, making them fire at distinct phases of the gamma oscillation. In contrast to increased food intake during optogenetic stimulation of LHVgat cells, food intake during gamma-rhythmic LS-LH stimulation was not changed. Overall this works provides new insight into the function of LH circuitry, that employs signalling at different time scales, which, in coordination with upstream and downstream circuits, regulates transitions between innate behaviors.
Doll, Daniel. "GABAergic inhibition regulates the synaptic activation of cholinergic-dependent plateau potentials." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ31343.pdf.
Full textSingh, Bhumika. "Differential regulation of glutamatergic and GABAergic synaptogenesis by BDNF and PRG1." [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2005/339/index.html.
Full textBerghuis, Paul. "Brain-derived neurotrophic factor and endocannabinoid functions i GABAergic interneuron development /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-125-8/.
Full textAsseri, Khalid. "Effects of AMBD and isovaline on GABAergic transmission in thalamic neurons." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/35078.
Full textSambandan, Sivakumar. "Associative synaptic plasticity in GABAergic interneurons of the rat dentate gyrus." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158478.
Full textRichards, Blake Aaron. "The role of GABAergic circuits in stimulus-instructed receptive field development." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533845.
Full textCao, Zhiwen, and 曹志文. "GABAergic transmission in developmental establishment of a gravity-related spatial reference." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47151304.
Full textpublished_or_final_version
Physiology
Master
Master of Philosophy
Joshi, Abhilasha. "Behaviour-dependent activity and synaptic organisation of septo-hippocampal GABAergic neurons." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:28b4b2bc-f782-4bc9-87af-233527171e60.
Full textHunt-Jones, Charlotte Amy. "Mutation analysis of GABAergic neuroinhibitory genes in childhood genetic generalised epilepsies." Thesis, Swansea University, 2015. https://cronfa.swan.ac.uk/Record/cronfa43036.
Full textParaskevopoulou, Foteini [Verfasser]. "Investigation of striatal GABAergic output modulation by glutamatergic input / Foteini Paraskevopoulou." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1234984288/34.
Full textWołoszynowska-Fraser, Marta Urszula. "Function of prefrontal GABAergic interneurons in behaviour : a relevance to schizophrenia." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=229738.
Full textNakamura, Shoko. "Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum." Kyoto University, 2005. http://hdl.handle.net/2433/144485.
Full textTomioka, Ryohei. "Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex." Kyoto University, 2005. http://hdl.handle.net/2433/144762.
Full text0048
新制・課程博士
博士(医学)
甲第11438号
医博第2861号
新制||医||895(附属図書館)
23081
UT51-2005-D188
京都大学大学院医学研究科脳統御医科学系専攻
(主査)教授 河野 憲二, 教授 大森 治紀, 教授 髙橋 良輔
学位規則第4条第1項該当
Parker, Krystal 'Detweiler'. "The role of cerebellar nuclear GABAergic neurotransmission in eyeblink motor control." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3355523.
Full textAsiedu, Marina N. "Spinal Sensitization Mechanisms Promoting Pain: Gabaergic Disinhibition and Pkmζ-Mediated Plasticity." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/232496.
Full textKasap, Zeynep. "Gephyrin regulates trans-synaptic signaling at GABAergic connections in the hippocampus." Doctoral thesis, SISSA, 2010. http://hdl.handle.net/20.500.11767/4774.
Full textPulido, Puentes María Camila. "Synaptic fluctuations in cerebellar interneurons connected by a single synaptic contact." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB007/document.
Full textThe unitary element of central synaptic transmission is a single synaptic site, with one active zone as presynaptic component and the postsynaptic density as postsynaptic partner. Due to technical limitations there is much uncertainty on the mode of functioning of a single synaptic site. To address this issue it is planned to perform paired recordings between interneurons of the molecular layers of the cerebellum. These neurons form synapses with a large quantal size, and occasionally displaying a single release site, and are thus favorable for this study. Postsynaptic responses will be studied in response to trains of presynaptic action potentials under various conditions. The results will be compared to a model supposing the obligatory binding of vesicles to a small complement of docking sites prior to exocytosis
Schümann, Anne. "Structural dynamics of GABAergic axons in the face of changing neuronal activity." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-151839.
Full textBlenau, Wolfgang, Cathleen Rotte, Jeannine Witte, Otto Baumann, and Bernd Walz. "Source, topography and excitatory effects of GABAergic innervation in cockroach salivary glands." Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2010/4435/.
Full textElfant, David J. "Inhibiting inhibition : GABAergic networks in the CA1 area of the rat hippocampus." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496867.
Full textMa, Ying [Verfasser]. "Effects of enhancing GABAergic transmission on sleep-associated memory consolidation / Ying Ma." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2012. http://d-nb.info/1021331007/34.
Full textChen, Jerry L. "Experience-dependent dendrite remodeling of GABAergic interneurons in the adult visual cortex." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57993.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 85-97).
An ever increasing amount of evidence is demonstrating that structural plasticity is a diverse and ongoing feature that contributes to plasticity in the adult brain. It was previously shown that dendritic arbors of inhibitory interneurons in superficial layer 2/3 can remodel in the adult cortex. Here, we investigated the role of these structural rearrangements during experience-dependent adult plasticity. Using in vivo two photon imaging, we monitored intemeuron dendritic branch tip remodeling in response to changes in visual experience in the adult mouse visual cortex. We find that branch tip dynamics are induced by novel experiences in a stimulus-specific manner. Visual deprivation produces rearrangements that are circuit-specific and are different for branch tips extending into LI or L2/3. The weakening of dendritic input onto these cells functions to reduce levels of inhibition in local cortical circuits. This reduced inhibitory tone provides more salience to remaining instructive input, allowing more structural and functional adaptations to occur. In order to better understand how synaptic plasticity accompanies these dendritic arbor rearrangements as well as other forms of structural plasticity, we developed a method to simultaneously monitor structural and synaptic dynamics in the mammalian brain using in vivo two-photon microscopy. Structural and synaptic components can be labeled in cortical neurons of mice in a cell type and laminar specific manner through co-injection of independent lentiviral vectors at a late embryonic or early postnatal age. We demonstrate that excitatory and inhibitory post-synaptic densities can be visualized by tagging fluorescent proteins to PSD95 and Gephyrin, respectively. Finally, we show that the fluorescent proteins, Teal and Venus, can be simultaneously excited and spectrally resolved through linear unmixing so that individual structural and synaptic components can be identified and followed over time. Through this approach, the relationship between synaptic and structural plasticity can be studied in the living brain.
by Jerry L. Chen.
Ph.D.
Cole, Katherine L. H. "GABAergic inhibition in learning and memory : examples from the cerebellum and hippocampus." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=192220.
Full textMonsivais, Pablo. "GABAergic inhibition of nucleus magnocellularis and laminaris by the superior olivary nucleus /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/10635.
Full textJin, Xiaoming. "Dendritic development of GABAergic cortical interneurons revealed by biolistic transfection with GFP." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2626.
Full textTitle from document title page. Document formatted into pages; contains vii, 218 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Li, Mei. "Specification and Determination of GABAergic and Glutamatergic Neural Phenotypes in Xenopus laevis." W&M ScholarWorks, 2004. https://scholarworks.wm.edu/etd/1539626449.
Full textDerera, Isabel Diane. "ALTERATIONS IN GABAERGIC NTS NEURON FUNCTION IN ASSOCIATION WITH TLE AND SUDEP." UKnowledge, 2018. https://uknowledge.uky.edu/physiology_etds/40.
Full textKazmierczak, Marlon. "Direct Reprogramming of distinct cells into GABAergic motor neurons in C. elegans." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19798.
Full textThe knock down of genes by RNAi has been fundamental to identify inhibitors of induced cell transdifferentiation in C. elegans (Tursun et al., 2011). Bacteria strains expressing dsRNA that target specific genes can be fed to the worm allowing straightforward whole-genome RNAi screens of the 20,000 genes in theC. elegans genome. However, many biological processes are regulated by more than one gene raising the need for simultaneous knock down of two or more genes to more fully interrogate the regulation of complex biological processes. Two approaches are currently available for double RNAi knockdown, − two bacteria strains expressing specific dsRNA can be mixed and grown together and fed simultaneously, which gives highly variable results. Alternatively, a new bacterial clone can be generated carrying a plasmid on which two RNAi targets of interest are 'stitched' together, which is not scalable. To address this challenge, we have developed a protocol using bacterial conjugation mediated by the 'Fertility Factor' (F) Episome in order to combine two different RNAi plasmids in a single bacterium. The objective was to be able to transfer a single RNAi plasmid to a large number of bacterial cells carrying different RNAi clones in one step in a high-throughput manner for large scale 'double' or even 'triple' RNAi screens. To find enhancers of induced unc-25::gfp expression in the germ line enabled by the depletion of histone chaperone LIN-53 (RbAp46/48 in humans), double RNAi clones targeting lin-53 and a total of 800 chromatin-related genes were generated and screened. We identified the Set1/MLL methyltransferase complex member RBBP-5 as a novel reprogramming barrier that putatively acts in a parallel pathway to LIN-53. Double RNAi by conjugation permits to reliably knock down two genes simultaneously in order to study genetic interactions at a genome-wide level, thus further increasing the versatility of RNAi screens to investigate interconnected biological processes.
Antonelli, Roberta. "The role of prolyl-isomerase PIN1 in GABAergic and glutamatergic synaptic transmission." Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/4893.
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