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Relevant bibliographies by topics / G-Hedgehog

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Journal articles

Academic literature on the topic 'G-Hedgehog'

Author: Grafiati

Published: 18 May 2024

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Journal articles on the topic "G-Hedgehog"

1

Gomes-Gonçalves, Sara, Sérgio Santos-Silva, Andreia V. S. Cruz, et al. "A Thorny Tale of Parasites: Screening for Enteric Protozoan Parasites in Hedgehogs from Portugal." Animals 14, no. 2 (2024): 326. http://dx.doi.org/10.3390/ani14020326.

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Enteric protozoan parasites, such as Blastocystis sp., Balantioides coli, Cryptosporidium spp., and Giardia duodenalis, may have implications for both animal and human health.Transmitted through the fecal–oral route, these parasites cause symptoms such as diarrhea, abdominal pain, and weight loss. This study investigated the presence of these enteric protozoan parasites and genetically characterized them in hedgehogs from Portugal. A total of 110 hedgehog stool samples were collected. Molecular detection methods showed an overall occurrence of protozoa in 1.82% (2/110 95% CI: 0.22–6.41) of hed

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2

Khera, Himanshi, Anupam Awasthi, and Sidharth Mehan. "Sonic Hedgehog Signaling Activation Promotes Cardioprotective Strategies." Current Signal Transduction Therapy 15, no. 2 (2020): 197–204. http://dx.doi.org/10.2174/1574362413666181113124958.

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Background: Hedgehog pathway plays a crucial role in the neovascularisation and angiogenesis during the embryonic stage in humans. Three genes of hedgehog protein isolated from humans are Sonic hedgehog, Desert hedgehog and Indian hedgehog gene. Two G-protein coupled receptors identified in the sonic hedgehog pathway served as patched receptor and smoothened receptor. Materials and Methods: Particularly, sonic hedgehog gene plays a versatile role in cellular homeostasis and can be a novel therapeutic target in the prevention of cardiovascular disorders. Further various sonic hedgehog modulator

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3

Rasmussen, Sophie Lund, Ane Elise Schrøder, Ronja Mathiesen, Jeppe Lund Nielsen, Cino Pertoldi, and David W. Macdonald. "Wildlife Conservation at a Garden Level: The Effect of Robotic Lawn Mowers on European Hedgehogs (Erinaceus europaeus)." Animals 11, no. 5 (2021): 1191. http://dx.doi.org/10.3390/ani11051191.

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We tested the effects of 18 models of robotic lawn mowers in collision with dead European hedgehogs and quantified the results into six damage categories. All models were tested on four weight classes of hedgehogs, each placed in three different positions. None of the robotic lawn mowers tested was able to detect the presence of dependent juvenile hedgehogs (<200 g) and all models had to touch the hedgehogs to detect them. Some models caused extensive damage to the hedgehog cadavers, but there were noteworthy differences in the degree of harm inflicted, with some consistently causing no dam

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4

Budiono, Novericko Ginger, Nicole Ting Qian Wen, Punithe Raj A/L Rajendran, and Annise Proboningrat. "Speedy Recovery of Subcutaneous Abscess and The Presence of Overgrown Nails in A Pygmy Hedgehog: A Case Report." Jurnal Medik Veteriner 6, no. 3 (2023): 126–35. http://dx.doi.org/10.20473/jmv.vol6.iss3.2023.126-135.

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This study reported that a 15-month-old intact female African pygmy hedgehog (Atelerix albiventris) was presented to IPB University Veterinary Teaching Hospital to evaluate a 1.5 cm × 1.5 cm × 0.5 cm mass on the left ventral thorax, three days after the mass was first discovered by the owner. Overgrown nails were observed on all four toes of each of the four limbs of the hedgehog. The body weight was 150 g, and the axial temperature was 36.5°C. The heart and respiratory rates were 180 per minute and 40 per minute, respectively. After a thorough physical examination, the patient was diagnosed w

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5

Mukhopadhyay, Saikat, and Rajat Rohatgi. "G-protein-coupled receptors, Hedgehog signaling and primary cilia." Seminars in Cell & Developmental Biology 33 (September 2014): 63–72. http://dx.doi.org/10.1016/j.semcdb.2014.05.002.

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6

Philipp, Melanie, and Marc G. Caron. "Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?" Current Biology 19, no. 3 (2009): R125—R127. http://dx.doi.org/10.1016/j.cub.2008.12.010.

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7

Philipp, Melanie, Gregory B. Fralish, Alison R. Meloni, et al. "Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase." Molecular Biology of the Cell 19, no. 12 (2008): 5478–89. http://dx.doi.org/10.1091/mbc.e08-05-0448.

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Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vertebrates, mainly, because the residues, where Smoothened is phosphorylated are not conserved from Drosophila to vertebrates. Given its molecular architecture, Smoothened signaling is likely to be regulated in a manner analogous to G protein–coupled receptors (GPCRs). Previously, it has been shown, that arrestins and GPCR kinases, (GRKs) not only des

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8

Norris, W., C. Neyt, P. W. Ingham, and P. D. Currie. "Slow muscle induction by Hedgehog signalling in vitro." Journal of Cell Science 113, no. 15 (2000): 2695–703. http://dx.doi.org/10.1242/jcs.113.15.2695.

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Muscles are composed of several fibre types, the precise combination of which determines muscle function. Whereas neonatal and adult fibre type is influenced by a number of extrinsic factors, such as neural input and muscle load, there is little knowledge of how muscle cells are initially determined in the early embryo. In the zebrafish, fibres of the slow twitch class arise from precociously specified myoblasts that lie close to the midline whereas the remainder of the myotome differentiates as fast myosin expressing muscle. In vivo evidence has suggested the Sonic Hedgehog glycoprotein, secr

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9

Meloni, Alison R., Gregory B. Fralish, Patrick Kelly, et al. "Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2." Molecular and Cellular Biology 26, no. 20 (2006): 7550–60. http://dx.doi.org/10.1128/mcb.00546-06.

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ABSTRACT Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activation of the transcription factor Gli. The activity of mammalian Smoothened is controlled by three different hedgehog proteins, Indian, Desert, and Sonic hedgehog, through their interaction with the Smoothened inhibitor Patched. However, the mechanisms of signal transduction from Smoothened are poorly understood. We show that a kinase which r

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10

Gvozdenovic-Jeremic, Jelena, and Ljiljana Mojovic. "Drug repositioning for a rare genetic disorder progressive osseous heteroplasia (POH)." Genetika 51, no. 1 (2019): 347–55. http://dx.doi.org/10.2298/gensr1901347g.

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Progressive osseous heteroplasia (POH) is an ultrarare genetic disease of progressive ectopic ossification caused by heterozygous inactivating mutations of GNAS, the gene encoding the alpha subunit of the G-stimulatory protein of adenylyl cyclase (Gs?). Extensive ossification of the deep connective tissues can result in ankylosis of affected joints and growth retardation of involved limbs. Inhibition of main molecular signaling, Hedgehog (Hh) pathway, by pharmacological methods may reduce the severity of ectopic bone formation in POH patients. Hh inhibitors currently used or known for other co

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