Relevant bibliographies by topics / G-Hedgehog

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  1. Journal articles

Academic literature on the topic 'G-Hedgehog'

Author: Grafiati
Published: 18 May 2024

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Journal articles on the topic "G-Hedgehog"

1

Gomes-Gonçalves, Sara, Sérgio Santos-Silva, Andreia V. S. Cruz, et al. "A Thorny Tale of Parasites: Screening for Enteric Protozoan Parasites in Hedgehogs from Portugal." Animals 14, no. 2 (2024): 326. http://dx.doi.org/10.3390/ani14020326.

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Enteric protozoan parasites, such as Blastocystis sp., Balantioides coli, Cryptosporidium spp., and Giardia duodenalis, may have implications for both animal and human health.Transmitted through the fecal–oral route, these parasites cause symptoms such as diarrhea, abdominal pain, and weight loss. This study investigated the presence of these enteric protozoan parasites and genetically characterized them in hedgehogs from Portugal. A total of 110 hedgehog stool samples were collected. Molecular detection methods showed an overall occurrence of protozoa in 1.82% (2/110 95% CI: 0.22–6.41) of hedgehogs, with Blastocystis being found in one hedgehog and Cryptosporidium being found in another. No evidence for the presence of B. coli or G. duodenalis was found. This study suggests that there is a need to stay aware of hedgehogs as potential hosts of enteric protozoa. Ongoing research and surveillance efforts are recommended to explore practical prevention and control strategies. The results contribute to the limited knowledge of these parasites in Portuguese hedgehog populations and underscore their potential relevance to both veterinary and public health.
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2

Khera, Himanshi, Anupam Awasthi, and Sidharth Mehan. "Sonic Hedgehog Signaling Activation Promotes Cardioprotective Strategies." Current Signal Transduction Therapy 15, no. 2 (2020): 197–204. http://dx.doi.org/10.2174/1574362413666181113124958.

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Background: Hedgehog pathway plays a crucial role in the neovascularisation and angiogenesis during the embryonic stage in humans. Three genes of hedgehog protein isolated from humans are Sonic hedgehog, Desert hedgehog and Indian hedgehog gene. Two G-protein coupled receptors identified in the sonic hedgehog pathway served as patched receptor and smoothened receptor. Materials and Methods: Particularly, sonic hedgehog gene plays a versatile role in cellular homeostasis and can be a novel therapeutic target in the prevention of cardiovascular disorders. Further various sonic hedgehog modulators have been reported working as futuristic drug molecules in the modulation of cardiovascular dysfunctions. Results: However, there was limited literature availability that has summarized the possible mechanism of targeting Sonic hedgehog signaling pathway. Conclusion: Thus, the present review is aimed at exploring the role of targeting sonic hedgehog protein signaling and modulators as well as to enlighten that how targeting sonic hedgehog protein involves in the amelioration of atherosclerosis, ischemic heart diseases, vascular endothelial dysfunction, heart failure and congenital heart diseases.
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3

Rasmussen, Sophie Lund, Ane Elise Schrøder, Ronja Mathiesen, Jeppe Lund Nielsen, Cino Pertoldi, and David W. Macdonald. "Wildlife Conservation at a Garden Level: The Effect of Robotic Lawn Mowers on European Hedgehogs (Erinaceus europaeus)." Animals 11, no. 5 (2021): 1191. http://dx.doi.org/10.3390/ani11051191.

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We tested the effects of 18 models of robotic lawn mowers in collision with dead European hedgehogs and quantified the results into six damage categories. All models were tested on four weight classes of hedgehogs, each placed in three different positions. None of the robotic lawn mowers tested was able to detect the presence of dependent juvenile hedgehogs (<200 g) and all models had to touch the hedgehogs to detect them. Some models caused extensive damage to the hedgehog cadavers, but there were noteworthy differences in the degree of harm inflicted, with some consistently causing no damage. Our results showed that the following technical features significantly increased the safety index of the robotic lawn mowers: pivoting blades, skid plates, and front wheel drive. Based on these findings, we encourage future collaboration with the manufacturers of robotic lawn mowers to improve the safety for hedgehogs and other garden wildlife species.
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4

Budiono, Novericko Ginger, Nicole Ting Qian Wen, Punithe Raj A/L Rajendran, and Annise Proboningrat. "Speedy Recovery of Subcutaneous Abscess and The Presence of Overgrown Nails in A Pygmy Hedgehog: A Case Report." Jurnal Medik Veteriner 6, no. 3 (2023): 126–35. http://dx.doi.org/10.20473/jmv.vol6.iss3.2023.126-135.

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This study reported that a 15-month-old intact female African pygmy hedgehog (Atelerix albiventris) was presented to IPB University Veterinary Teaching Hospital to evaluate a 1.5 cm × 1.5 cm × 0.5 cm mass on the left ventral thorax, three days after the mass was first discovered by the owner. Overgrown nails were observed on all four toes of each of the four limbs of the hedgehog. The body weight was 150 g, and the axial temperature was 36.5°C. The heart and respiratory rates were 180 per minute and 40 per minute, respectively. After a thorough physical examination, the patient was diagnosed with subcutaneous abscesses and overgrown nails. The abscess was surgically resected using a local anesthetic. The overgrown nails were trimmed to prevent further injury and the recurrence of abscesses. Following surgery, the hedgehog was discharged directly from the hospital and treated using Amoxicillin 15 mg/kg per oral every 12 hours for seven days, daily routine wound cleaning with sodium chloride, and topical powder of neomycin sulfate 5 mg/g and bacitracin 250 IU/g. The patient responded effectively to the systemic treatment, and medical signs and symptoms resolved. The hedgehog fully recovered from the subcutaneous abscess 14 days after the first hospital visit. No recurrence was reported in the subsequent month after resolution.
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5

Mukhopadhyay, Saikat, and Rajat Rohatgi. "G-protein-coupled receptors, Hedgehog signaling and primary cilia." Seminars in Cell & Developmental Biology 33 (September 2014): 63–72. http://dx.doi.org/10.1016/j.semcdb.2014.05.002.

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6

Philipp, Melanie, and Marc G. Caron. "Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?" Current Biology 19, no. 3 (2009): R125—R127. http://dx.doi.org/10.1016/j.cub.2008.12.010.

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7

Philipp, Melanie, Gregory B. Fralish, Alison R. Meloni, et al. "Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase." Molecular Biology of the Cell 19, no. 12 (2008): 5478–89. http://dx.doi.org/10.1091/mbc.e08-05-0448.

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Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vertebrates, mainly, because the residues, where Smoothened is phosphorylated are not conserved from Drosophila to vertebrates. Given its molecular architecture, Smoothened signaling is likely to be regulated in a manner analogous to G protein–coupled receptors (GPCRs). Previously, it has been shown, that arrestins and GPCR kinases, (GRKs) not only desensitize G protein–dependent receptor signaling but also function as triggers for GPCR trafficking and formation of signaling complexes. Here we describe that a GRK contributes to Smoothened-mediated signaling in vertebrates. Knockdown of the zebrafish homolog of mammalian GRK2/3 results in lowered Hedgehog transcriptional responses, impaired muscle development, and neural patterning. Results obtained in zebrafish are corroborated both in cell culture, where zGRK2/3 phosphorylates Smoothened and promotes Smoothened signal transduction and in mice where deletion of GRK2 interferes with neural tube patterning. Together, these data suggest that a GRK functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development.
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8

Norris, W., C. Neyt, P. W. Ingham, and P. D. Currie. "Slow muscle induction by Hedgehog signalling in vitro." Journal of Cell Science 113, no. 15 (2000): 2695–703. http://dx.doi.org/10.1242/jcs.113.15.2695.

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Muscles are composed of several fibre types, the precise combination of which determines muscle function. Whereas neonatal and adult fibre type is influenced by a number of extrinsic factors, such as neural input and muscle load, there is little knowledge of how muscle cells are initially determined in the early embryo. In the zebrafish, fibres of the slow twitch class arise from precociously specified myoblasts that lie close to the midline whereas the remainder of the myotome differentiates as fast myosin expressing muscle. In vivo evidence has suggested the Sonic Hedgehog glycoprotein, secreted from the notochord, controls the formation of slow twitch and fast twitch muscle fates. Here we describe an in vitro culture system that we have developed to test directly the ability of zebrafish myoblasts to respond to exogenous Sonic Hedgehog peptide. We find that Sonic Hedgehog peptide can control the binary cell fate choice of embryonic zebrafish myoblasts in vitro. We have also used this culture system to assay the relative activities of different Hedgehog-family proteins and to investigate the possible involvement of heterotrimeric G-proteins in Hedgehog signal transduction.
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9

Meloni, Alison R., Gregory B. Fralish, Patrick Kelly, et al. "Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2." Molecular and Cellular Biology 26, no. 20 (2006): 7550–60. http://dx.doi.org/10.1128/mcb.00546-06.

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ABSTRACT Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activation of the transcription factor Gli. The activity of mammalian Smoothened is controlled by three different hedgehog proteins, Indian, Desert, and Sonic hedgehog, through their interaction with the Smoothened inhibitor Patched. However, the mechanisms of signal transduction from Smoothened are poorly understood. We show that a kinase which regulates signaling by many “conventional” 7TM G-protein-coupled receptors, G protein-coupled receptor kinase 2 (GRK2), participates in Smoothened signaling. Expression of GRK2, but not catalytically inactive GRK2, synergizes with active Smoothened to mediate Gli-dependent transcription. Moreover, knockdown of endogenous GRK2 by short hairpin RNA (shRNA) significantly reduces signaling in response to the Smoothened agonist SAG and also inhibits signaling induced by an oncogenic Smoothened mutant, Smo M2. We find that GRK2 promotes the association between active Smoothened and β-arrestin 2. Indeed, Gli-dependent signaling, mediated by coexpression of Smoothened and GRK2, is diminished by β-arrestin 2 knockdown with shRNA. Together, these data suggest that GRK2 plays a positive role in Smoothened signaling, at least in part, through the promotion of an association between β-arrestin 2 and Smoothened.
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10

Gvozdenovic-Jeremic, Jelena, and Ljiljana Mojovic. "Drug repositioning for a rare genetic disorder progressive osseous heteroplasia (POH)." Genetika 51, no. 1 (2019): 347–55. http://dx.doi.org/10.2298/gensr1901347g.

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Progressive osseous heteroplasia (POH) is an ultrarare genetic disease of progressive ectopic ossification caused by heterozygous inactivating mutations of GNAS, the gene encoding the alpha subunit of the G-stimulatory protein of adenylyl cyclase (Gs?). Extensive ossification of the deep connective tissues can result in ankylosis of affected joints and growth retardation of involved limbs. Inhibition of main molecular signaling, Hedgehog (Hh) pathway, by pharmacological methods may reduce the severity of ectopic bone formation in POH patients. Hh inhibitors currently used or known for other conditions may be potential candidate drugs for treating this debilitating disease. In this study, three potential Hedgehog pathway inhibitors such as arsenic trioxide, statin, and vitamin D and their combinations were tested on subcutaneous mesenchymal progenitor (SMP) cells of G?s f/f mice model for possible therapeutic application for POH. The combination of these three drugs at their significantly reduced concentrations retained anti-osteogenic activity in SMP cells with aberrant Hedgehog activity. In that light, we propose here a potential new approach of the drug combination in order to reduce potential toxicity, the side effect and increase success rate for Hh inhibitors drug repositioning.
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