Relevant bibliographies by topics / Fusion

Academic literature on the topic 'Fusion'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Fusion"

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Chiu, Readman, Ka Ming Nip, and Inanc Birol. "Fusion-Bloom: fusion detection in assembled transcriptomes." Bioinformatics 36, no. 7 (December 2, 2019): 2256–57. http://dx.doi.org/10.1093/bioinformatics/btz902.

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Abstract Summary Presence or absence of gene fusions is one of the most important diagnostic markers in many cancer types. Consequently, fusion detection methods using various genomics data types, such as RNA sequencing (RNA-seq) are valuable tools for research and clinical applications. While information-rich RNA-seq data have proven to be instrumental in discovery of a number of hallmark fusion events, bioinformatics tools to detect fusions still have room for improvement. Here, we present Fusion-Bloom, a fusion detection method that leverages recent developments in de novo transcriptome assembly and assembly-based structural variant calling technologies (RNA-Bloom and PAVFinder, respectively). We benchmarked Fusion-Bloom against the performance of five other state-of-the-art fusion detection tools using multiple datasets. Overall, we observed Fusion-Bloom to display a good balance between detection sensitivity and specificity. We expect the tool to find applications in translational research and clinical genomics pipelines. Availability and implementation Fusion-Bloom is implemented as a UNIX Make utility, available at https://github.com/bcgsc/pavfinder and released under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/. Supplementary information Supplementary data are available at Bioinformatics online.
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Lin, Hao, Yujie Liu, Ruitao Zhou, Yutao Feng, Huiya Cao, Peisu Suo, JIA Guo, and Shifu Chen. "Noncanonical RET fusions in Chinese patients with non-small cell lung cancer from DNA-based next-generation sequencing." Journal of Clinical Oncology 42, no. 16_suppl (June 1, 2024): e20000-e20000. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e20000.

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e20000 Background: The FDA has approved selpercatinib and pralsetinib for the treatment of metastatic RET fusion-positive non-small cell lung cancer in adult patients. Although the overall response rate is high and the response is durable, the outcomes may vary due to different fusion types of the same driver gene. Methods: We retrospectively collected and analyzed 14062 samples (tumour tissue or plasma) from Chinese lung cancer patients who underwent tissue-based or ctDNA-based next-generation sequencing (NGS) assays at HaploX Genomic Sequencing Center from May 18, 2020, to January 11, 2024. All samples with a RET gene fusion were included and classified based on the fusion partner gene and breakpoint position. Results: A total of 157 (1.1%) samples with DNA-based NGS harbored a RET gene fusion. Among the samples with a RET gene fusion, the most common RET fusion partners at the DNA level were KIF5B (73.2%) and CCDC6 (21.0%). We categorized RET fusions into canonical fusions and noncanonical fusions based on fusion partner and breakpoint position, and the proportions of canonical fusions and noncanonical fusions were 88.5% (139/157) and 11.5% (18/157) respectively. Among the samples with a noncanonical RET fusion, 5 samples harbored a RET fusion with an uncommon fusion partner, it remains unclear whether these fusions lead to RET activation. Conclusions: In this retrospective study, we identify different types of RET fusions in Chinese lung cancer patients. The majority are canonical fusions, which can benefit from tyrosine kinase inhibitors in clinical, the rest are noncanonical fusions, and their role in precision therapy needs further verification by RNA-based NGS or other assays. All in all, our research helps guide precision therapy in clinical settings. [Table: see text]
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Thomson, Ashlee J., Jacqueline A. Rehn, Susan L. Heatley, Laura N. Eadie, Elyse C. Page, Caitlin Schutz, Barbara J. McClure, et al. "Reproducible Bioinformatics Analysis Workflows for Detecting IGH Gene Fusions in B-Cell Acute Lymphoblastic Leukaemia Patients." Cancers 15, no. 19 (September 26, 2023): 4731. http://dx.doi.org/10.3390/cancers15194731.

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B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by diverse genomic alterations, the most frequent being gene fusions detected via transcriptomic analysis (mRNA-seq). Due to its hypervariable nature, gene fusions involving the Immunoglobulin Heavy Chain (IGH) locus can be difficult to detect with standard gene fusion calling algorithms and significant computational resources and analysis times are required. We aimed to optimize a gene fusion calling workflow to achieve best-case sensitivity for IGH gene fusion detection. Using Nextflow, we developed a simplified workflow containing the algorithms FusionCatcher, Arriba, and STAR-Fusion. We analysed samples from 35 patients harbouring IGH fusions (IGH::CRLF2 n = 17, IGH::DUX4 n = 15, IGH::EPOR n = 3) and assessed the detection rates for each caller, before optimizing the parameters to enhance sensitivity for IGH fusions. Initial results showed that FusionCatcher and Arriba outperformed STAR-Fusion (85–89% vs. 29% of IGH fusions reported). We found that extensive filtering in STAR-Fusion hindered IGH reporting. By adjusting specific filtering steps (e.g., read support, fusion fragments per million total reads), we achieved a 94% reporting rate for IGH fusions with STAR-Fusion. This analysis highlights the importance of filtering optimization for IGH gene fusion events, offering alternative workflows for difficult-to-detect high-risk B-ALL subtypes.
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Zhou, Xinliang, Liyuan He, Zhisong Fan, Jing Zuo, Li Feng, Long Wang, Jing Han, et al. "ALK fusion typing and response to crizotinib in ALK+ lung cancer-naive patients." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): e21008-e21008. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e21008.

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e21008 Background: Anaplastic lymphoma kinase (ALK) is one of the major oncogenic driver genes in lung cancer, and fusion as the main mutation type, of which EML4 is the most common fusion ligand. With the development of next-generation sequencing (NGS), some other rare fusion ligands and complex fusions have been discovered. The prognosis of patients with EML4-ALK fusion, non EML4-ALK fusion and multiple ALK fusion was different. Methods: We retrospectively analyzed NGS (including tissue, blood, or other body fluid samples) in 61 patients with ALK[+] lung cancer, including 59 patients with NSCLC and 2 patients with SCLC. Grouping was determined according to whether it was EML4-ALK fusion and multiple fusion. Results: In our data, the partner fused to the ALK gene are diverse, including EML4, KIF5B, TSN and others. Among them, EML4 was the most common ligand in ALK[+] NSCLC, accounting for 93.2% (55/59). Among the different fusion sites of EML4-ALK, V1 (E13:A20) and V3 (E6:A20) mutations were the most common, accounting for 45.5% (25/55) and 41.8% (23/55), respectively. Several novel ALK fusion partners were discovered in this study, including MCFD2, LINC01251, MVP17, CREG2, LINCO1498 and so on. In addition, the incidence of intergenic sequence-ALK fusions was 16.4% (10/61), such as ANXA4-ALK(A[intergenic]:A20), CREG2-ALK (C[intergenic]:A20), HCN1-ALK(H[intergenic]:A20), TSN-ALK(T[intergenic]:A20), RSAD2-ALK(R [intergenic]:A20) and so on. 19.0% (12/61) of the patient had multiple fusion, of which only one patient had multiple fusion of EML4-ALK (V2+V5'+V3a/b), and the remaining patients had co-fusion of EML4-ALK and non EML4-ALK (Table). V3 were more likely to coexist with non EML4-ALK fusions than V1 or other variants (P = 0.047). Multiple fusions were more likely to occur with non EML4-ALK fusions (P < 0.000). Compared with EML4-ALK fusion, mPFS treated with crizotinib in non EML4-ALK fusion were significantly shorter (18.2 vs. 8.5 months, P = 0.035). In the context of crizotinib treatment, multiple fusions were associated with worse mPFS compared with single fusions (13.8 vs. 8.4 months, P = 0.008). In addition, For SCLC patients with ALK fusion (n = 2), the PFS of crizotinib treatment were 8.0 and 30.6 months, respectively. Conclusions: Due to the heterogeneity of tumor development resulting in the diversity of ALK fusions, non EML4-ALK fusions and multiple fusions imply a poorer response to crizotinib. ALK gene status prior to ALK-TKI therapy helps predict drug efficacy and patient prognosis.[Table: see text]
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Zhou, Xinliang, Liyuan He, Zhisong Fan, Jing Zuo, Li Feng, Long Wang, Jing Han, et al. "ALK fusion typing and response to crizotinib in ALK+ lung cancer-naive patients." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): e21008-e21008. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e21008.

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e21008 Background: Anaplastic lymphoma kinase (ALK) is one of the major oncogenic driver genes in lung cancer, and fusion as the main mutation type, of which EML4 is the most common fusion ligand. With the development of next-generation sequencing (NGS), some other rare fusion ligands and complex fusions have been discovered. The prognosis of patients with EML4-ALK fusion, non EML4-ALK fusion and multiple ALK fusion was different. Methods: We retrospectively analyzed NGS (including tissue, blood, or other body fluid samples) in 61 patients with ALK[+] lung cancer, including 59 patients with NSCLC and 2 patients with SCLC. Grouping was determined according to whether it was EML4-ALK fusion and multiple fusion. Results: In our data, the partner fused to the ALK gene are diverse, including EML4, KIF5B, TSN and others. Among them, EML4 was the most common ligand in ALK[+] NSCLC, accounting for 93.2% (55/59). Among the different fusion sites of EML4-ALK, V1 (E13:A20) and V3 (E6:A20) mutations were the most common, accounting for 45.5% (25/55) and 41.8% (23/55), respectively. Several novel ALK fusion partners were discovered in this study, including MCFD2, LINC01251, MVP17, CREG2, LINCO1498 and so on. In addition, the incidence of intergenic sequence-ALK fusions was 16.4% (10/61), such as ANXA4-ALK(A[intergenic]:A20), CREG2-ALK (C[intergenic]:A20), HCN1-ALK(H[intergenic]:A20), TSN-ALK(T[intergenic]:A20), RSAD2-ALK(R [intergenic]:A20) and so on. 19.0% (12/61) of the patient had multiple fusion, of which only one patient had multiple fusion of EML4-ALK (V2+V5'+V3a/b), and the remaining patients had co-fusion of EML4-ALK and non EML4-ALK (Table). V3 were more likely to coexist with non EML4-ALK fusions than V1 or other variants (P = 0.047). Multiple fusions were more likely to occur with non EML4-ALK fusions (P < 0.000). Compared with EML4-ALK fusion, mPFS treated with crizotinib in non EML4-ALK fusion were significantly shorter (18.2 vs. 8.5 months, P = 0.035). In the context of crizotinib treatment, multiple fusions were associated with worse mPFS compared with single fusions (13.8 vs. 8.4 months, P = 0.008). In addition, For SCLC patients with ALK fusion (n = 2), the PFS of crizotinib treatment were 8.0 and 30.6 months, respectively. Conclusions: Due to the heterogeneity of tumor development resulting in the diversity of ALK fusions, non EML4-ALK fusions and multiple fusions imply a poorer response to crizotinib. ALK gene status prior to ALK-TKI therapy helps predict drug efficacy and patient prognosis.[Table: see text]
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Karan, Canan, Elaine Tan, Humaira Sarfraz, Christine Marie Walko, Richard D. Kim, Todd C. Knepper, and Ibrahim Halil Sahin. "Clinical and molecular characterization of fusion genes in colorectal cancer." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): e15568-e15568. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e15568.

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e15568 Background: Next-generation sequencing (NGS) based molecular profiling technologies have revealed several oncogenic fusion genes that are actionable with small molecule inhibitors leading to practice change, particularly in lung cancer. The molecular and clinical characteristics of these gene fusions are not well defined in colorectal cancer patients (CRC). In this study, we aimed to define clinical and molecular characteristics of fusion genes in patients with CRC who underwent molecular profiling. Methods: Molecular characteristics of tissue confirmed 917 CRC patients were retrieved from the Moffit Cancer Center Clinical Genomics Action Committee database. Patients’ demographic and clinicopathological features and treatment history were collected from the database. All fusion genes were shown by hybridization-based NGS computational algorithms that determined cancer‐related genes, including single‐nucleotide variations, indels, microsatellite instability (MSI) status. Results: Among a total of 917 patients, 24 patients with CRC (2.6%) were found to have at least one fusion gene with a total number of 26 pathogenic fusions. The gene fusions are shown in Table. The most common, potentially targetable, fusion genes in our cohort were (1) RET fusions 0.5% (5/917), (2) ALK fusions 0.4% (4/917), (3) ROS1 fusions 0.2% (2/917), (4) NTRK1 fusion 0.1% (1/917), (5) NRG1 fusion 0.1% (1/917). Fusion genes were more common in MSI-H CRC (N = 27), and 3 (11.1%) patients with MSI-H CRC were found to have fusion genes [(RET (2) and NTRK(1)]. Fusion genes were present in both RAS wild-type (54%; 13/24) and RAS mutant (46%; 11/24) tumors. Most patients were older than 50 years (75%, 18/24) and had left-sided tumor (61.1%) tumor. Conclusions: Fusion genes are rare events in CRC. While fusion genes seem to be more prevalent in MSI-H CRC, RAS status does not correlate with the frequency of fusion genes. Actionable RET and ALK/ROS gene fusion are more common than NTRK fusion genes in this cohort of CRC patients.[Table: see text]
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Zhu, Bowen, Xinlin Zhen, Zeqing Gao, Suo Peisu, Jing Zhang, and Wenzhe Fan. "The frequency of rare ALK fusions and their clinical significance in NSCLC." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): e21012-e21012. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e21012.

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e21012 Background: ALK fusion is one of the key driver mechanisms in non-small cell lung cancer. In some case reports, some rare mutant forms have also been found to be active and drug-susceptible. There are few reports on the detection and verification methods of rare ALK fusions. Here, we counted the rare fusions of ALK detected by NGS and verified them by other methods. Methods: We analyzed 184 patients with NSCLC harboring ALK-rearrangement detected by NGS from January 2020 to January 2022. We counted the rare ALK fusion forms, and selected two of them for verification by RNA sequencing or immunohistochemistry. Results: Of the 184 patients with ALK fusion that we included, 105 were female and 79 were male (medium age 53). Most female were non-smokers except one while nearly 50% male were smokers. EML4-ALK fusion accounted for the highest proportion (170, 92.4%), 5 were ALK fusions with other 5’ partners ( C2orf44, KCNG3, KIF5B, KDM5A, DCTN1), 6 were intergenic region- ALK rearrangements, 2 were fusions without transcription initiation region, and 1 was LOC399815 -ALK and ALK-EML4 double fusion. Rare fusion forms accounted for less than 10%. We further verified two of these rare fusion mutations by RNA sequencing or immunohistochemistry. Interestingly, one of the patients with a KCNG3-exon1- ALK-exon20 fusion detected by DNA sequencing was confirmed to be an EML4-ALK fusion by RNA sequencing, and another patient with an intergenic region- ALK fusion was confirmed positive by immunohistochemistry. Conclusions: The vast majority of ALK fusions are EML4-ALK fusions, but there are a small number of other forms of fusions. DNA sequencing, RNA sequencing and ICH may give different conclusions for ALK fusions, which may be limited by the detection method. For some rare fusion forms, a variety of methods can be used to detect whether it is an active ALK fusion form.
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Haferlach, Claudia, Wencke Walter, Manja Meggendorfer, Constance Baer, Anna Stengel, Stephan Hutter, Niroshan Nadarajah, Wolfgang Kern, and Torsten Haferlach. "The Diverse Landscape of Fusion Transcripts in 25 Different Hematological Entities." Blood 136, Supplement 1 (November 5, 2020): 16–17. http://dx.doi.org/10.1182/blood-2020-137518.

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Background: Genomic alterations are a hallmark of hematological malignancies and comprise small nucleotide variants, copy number alterations and structural variants (SV). SV lead to the co-localization of remote genomic material resulting in 2 different scenarios: 1. breakpoints are located within 2 genes leading to a chimeric fusion gene and a fusion transcript, 2. breakpoints are located outside of genes, frequently placing one nearby gene under the influence of the regulatory sequences of the partner, leading to a deregulated - usually increased - transcription. Aim: The frequency of fusion transcripts was determined across hematological entities in order to 1) identify recurrent partner genes across entities, 2) evaluate the specificity of fusion transcripts and genes involved in fusions for distinct entities. Cohort and Methods: Whole transcriptome sequencing (WTS) was performed in 3,549 patients in 25 different hematological entities (table). 101 bp paired-end reads were produced on a NovaSeq 6000 system (Illumina, San Diego, CA) with a yield between 35 and 125 million paired reads per sample. Potential fusions were called using 3 different callers (Arriba, STAR-Fusion, Manta), only fusions called by at least 2 callers, validated by whole genome sequencing (data available for all cases) and with at least one protein coding partner were kept for further analyses. Reciprocal fusion transcripts were counted as one fusion event. Results: In total 1,309 fusion transcripts were identified in 932 of 3,549 (26.3%) patients. 221 patients showed &gt; 1 fusion (2 fusions: 150, 3: 36, &gt;3: 35). 806 distinct fusion transcripts were divided into recurrent fusions (n=50) and unique fusions, i.e. found only in 1 case (n=756). Out of 932 patients with at least 1 fusion, 541 (58%) patients harbored a minimum of one recurrent fusion. The proportion of patients harboring any or a recurrent fusion varied substantially between different entities with high frequencies for both in CML (96.5%/96.5%), B-lineage ALL (53.1%/41.3%), AML (42.8%/31.2%), and T-lineage ALL (35.3%/12.6%). In several myeloid entities low fusion frequencies were observed (e.g. PMF, MDS/MPN-U, MDS, figure A). No fusion transcripts were detected in ET. Strikingly, fusions were detected in a substantial proportion of cases with lymphoid neoplasms but only very few occurred recurrently (e.g. T-PLL: 47.8%/4.3%, FL: 39.3%/4.9%, figure A). With regard to age, only patients with AML and T-ALL harboring recurrent fusions were significantly younger than corresponding cases without recurrent fusions (59 vs 71 yrs, p&lt;0.0001; 35 vs 38 yrs, p=0.02). Only in AML patients with unique fusions were older (70 vs 66 yrs, p=0.02), while no age differences were observed between cases with and without unique fusions in other entities. 23/50 (46%) of the recurrent fusions were specific for one entity (12 in myeloid, 11 in lymphatic entities), while the other 54% (27/50) were observed in 2 to 7 different entities. Of these 27 recurrent fusions, only 16 fusions were shared between myeloid and lymphatic entities, while 10 were restricted to myeloid and one fusion to lymphatic entities (figure B). In total 1,270 different genes were involved in the 806 distinct fusions, indicating a broad spectrum of potential functional impact. 54 genes were involved only in recurrent fusions, 27 genes in both recurrent and unique fusions, while 1,189 genes were solely involved in unique fusions. Four genes involved in recurrent fusions and 32 genes involved in unique fusions are FDA approved drug targets (Human Protein Atlas). Only 16% (199/1270) of the genes were involved in more than one fusion: 3 genes (ETV6, KMT2A, RUNX1) in 14 fusions, 2 genes (ABL1, BCR) in 11 fusions, 16 genes in 4 to 10 fusions, 38 genes in 3 fusions, 140 in 2 fusions. Several genes frequently involved in fusions in hematological malignancies (e.g. ABL1, ETV6, KMT2A) and 78/1189 genes only involved in unique fusions were also reported to be partners in fusions in non-hematological malignancies. Conclusions: As known, in CML and acute several leukemias a high proportion of patients harbor fusions of which many occur recurrently, suggesting a substantial pathogenic impact and, thus, requiring detection in a diagnostic work-up. In BCR-ABL1 negative chronic myeloid malignancies few fusions were observed while lymphoma patients carry frequently non-recurrent fusions with so far unknown impact on pathogenesis and prognosis. Disclosures No relevant conflicts of interest to declare.
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Zhang, Xuhui, Dongsheng Chen, Qin Zhang, Qianqian Duan, Qing WANG, Si Li, and Mingzhe Xiao. "Characterization of NTRK gene fusion events in solid tumors among Chinese patients." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e15040-e15040. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15040.

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e15040 Background: NTRK fusions are actionable genomic alterations detected across tumor types. NTRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and paediatric tumour types. Here, we update the detection of NTRK gene fusions across tumor types and further describe fusion partner characteristics among Chinese patients. Methods: Samples submitted for clinical molecular profiling were retrospectively analyzed for NTRK fusion events. Method for identifying NTRK fusions was DNA-based next-generation sequencing that tumour DNA is extracted from formalin-fixed paraffin-embedded tissue. All NTRK fusion partners were identified for intact functional domains, domain prediction, breakpoints, frame retention and co-occurring alterations. Results: A total of 64 NTRK fusion events (0.26% of 24,451) were identified. NTRK fusions are characteristic in a few rare types of cancer, such as melanoma, glioma and carcinomas of the thyroid, lung and colon, but they are also infrequently seen in some uncommon cancers, such as secretory carcinoma of the breast or salivary gland and infantile fibrosarcoma. Among the fusions, NTRK1 (0.08% of 24,430), NTRK2 (0.02% of 24,445), NTRK3 (0.15% of 24,414) were identified. Twenty-six unique fusion partners were identified, the most common in NTRK1 fusion being TPM3 (23.8%), NTRK2 fusion being AGTPBP1 (33.3%), and NTRK3 fusion being TFG (13.5%). Almost 53.8 % (14 of 26) of all fusion events are expected to include the transmembrane domain contributed by the NTRK fusion partner. The most commonly identified breakpoints occur in exon 14 and exon 17 and in exon 15 and exon 20, in NTRK1, NTRK3, respectively. Conclusions: NTRK fusion products are diverse across tumor types, but the significance of these variations is not clear. The biological and clinical implications of retaining certain domains of NTRK and of fusion partners warrants further investigation.
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Priedigkeit, Nolan, Alinés Lebrón-Torres, Janny Liao, Jean-Baptiste Alberge, Stefania Morganti, Jakob Weiss, Jorge Gomez Tejeda Zanudo, et al. "Abstract GS03-09: Characterization and proposed therapeutic exploitation of fusion RNAs in metastatic breast cancers." Cancer Research 84, no. 9_Supplement (May 2, 2024): GS03–09—GS03–09. http://dx.doi.org/10.1158/1538-7445.sabcs23-gs03-09.

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Abstract BACKGROUND: Large-scale genomic studies such as The Cancer Genome Atlas (TCGA) and Pan-Cancer Analysis of Whole Genomes (PCAWG) show that the breast cancer (BrCa) genome is dominated by structural variation (SV) rather than single base pair mutations, producing a fertile environment for gene fusions. In this study, we implement a rigorous, expression-based approach to create a comprehensive landscape of fusion RNAs in metastatic breast cancer (MBC). We find fusion RNAs—many of which are novel involving known oncogenes—are surprisingly common in the advanced setting and credential their use as base-editing therapeutic targets. METHODS: Two retrospective cohorts of MBC RNA-sequencing data were analyzed— Dana-Farber Cancer Institute CCPM (n = 252 cases, 276 specimens), MichiganCSER (n = 171 cases, 190 specimens)—with a Fusion MetaCaller that integrates 5 unsupervised fusion-finding algorithms. Fusion RNAs identified in at least 2 callers (High-Confidence) and absent in RNA-seq from normal tissue (Cancer-Specific) were classified as HCCS-Fusions. Further removal of common artifactual fusions was performed using public databases. Expression of each HCCS-Fusion was quantified using a supervised method (FusionInspector)—expressed HCCS-Fusions were defined as having a Fusion Fragment Per Million (FFPM) value &gt; 0.1 and at least 10% of read counts mapping to the fusion breakpoint versus the flanking 5’ or 3’ partners’ exons. Normalized gene-level expression abundances were calculated to correlate transcriptomic features (gene expression, PAM50) with fusion RNAs. Recurrent, potentially pathogenic fusion RNAs were annotated using OncoKB and outlier expressed fusions (Q3 FFPM + [1.5 X IQR]) were interrogated. RESULTS: The frequency of HCCS-Fusions differed between subtypes with basal BrCa harboring the most per tumor followed by Her2, LumB and LumA—with a median HCCS-Fusion count of 13, 12, 7, 4 respectively. 64.5% of cases harbored a HCCS-Fusion in an OncoKB cancer-related gene. The most recurrent fusions involving a cancer-related gene were 5’ ESR1 fusions (14 cases)—all with in-frame breakpoints near exon6/7, disrupting ESR1’s ligand binding domain. 13 of 14 ESR1 fusions were called in Luminal B (LumB) metastases (Fisher’s exact enrichment p &lt; 0.005 vs other subtypes)—defining an ESR1 fusion frequency of 6.5% in LumB disease. Beyond ESR1, we identify recurrent, low-frequency (2-4 cases) in-frame kinase fusions involving FGFR2, ADK, TLK2, PRKCA, BRAF, CHKA, CSNK1D, NEK11, TNIK—some potentially targetable with FDA-approved small molecule inhibitors—as well as recurrent, predicted loss-of-function fusion RNAs in NF1, MSI2, USP32, PTEN, and CDH1. Lastly, 33.6% of cases harbored at least one outlier expressed fusion RNA; including highly expressed in-frame fusions involving known BrCa mediators such as ERBB2, BRCA1, ARID1B, RPS6KB1/2, PIK3R3, AXIN1, TGFB1/2, FOXP1, PAK1, and CREBBP. CONCLUSIONS: Taken together, these results demonstrate that fusion RNAs in MBC—some recurrent, many highly expressed and unique to individual tumors—are common. We create the most comprehensive catalog of ESR1 fusions in MBC, better define their frequency, discover their enrichment in LumB-like tumors, and will discuss clinicopathologic and transcriptomic features associated with ESR1 fusion positive disease. We identify druggable fusions that would likely be missed by current testing standards, find recurrent loss-of-function fusion RNAs, and show that over one-third of metastatic cases harbor at least one outlier expressed fusion—many of which involve BrCa-related genes. In summary, we propose that fusion RNAs are a driving and perhaps overlooked mechanism of tumor evolution in therapy-resistant disease and postulate fusion transcripts present a compelling therapeutic opportunity in MBC. Preliminary data targeting fusion RNA breakpoints using a novel RNA base-editing approach will be discussed. Citation Format: Nolan Priedigkeit, Alinés Lebrón-Torres, Janny Liao, Jean-Baptiste Alberge, Stefania Morganti, Jakob Weiss, Jorge Gomez Tejeda Zanudo, Albert Grinshpun, Melissa Hughes, Karla Helvie, Kerry Sendrick, Kyleen Nguyen, Sarah Strauss, Janet Files, Maxwell Lloyd, Nikhil Wagle, Chip Stewart, Eric Winer, Bruce Johnson, Yvonne Li, Rinath Jeselsohn, Sara Tolaney, Daniel Abravanel, Nancy Lin, Heather Parsons, Gad Getz, Steffi Oesterreich, Adrian Lee, Todd Golub. Characterization and proposed therapeutic exploitation of fusion RNAs in metastatic breast cancers [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr GS03-09.
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Dissertations / Theses on the topic "Fusion"

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Hughes, Katelyn. "Gene fusions in cancer: Classification of fusion events and regulation patterns of fusion pathway neighbors." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-theses/764.

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Cancer is a leading cause of death worldwide, resulting in an estimated 1.6 million mortalities and 600,000 new cases in the US alone in 2015. Gene fusions, hybrid genes formed from two originally separated genes, are known drivers of cancer. However, gene fusions have also been found in healthy cells due to routine errors in replication. This project aims to understand the role of gene fusion in cancer. Specifically, we seek to achieve two goals. First, we would like to develop a computational method that predicts if a gene fusion event is associated with the cancer or healthy sample. Second, we would like to use this information to determine and characterize molecular mechanisms behind the gene fusion events. Recent studies have attempted to address these problems, but without explicit consideration of the fact that there are overlapping fusion events in both cancer and healthy cells. Here, we address this problem using FUsion Enriched Learning of CANcer Mutations (FUELCAN), a semi-supervised model, which classifies all overlapping fusion events as unlabeled to start. The model is trained using the known cancer and healthy samples and tested using the unlabeled dataset. Unlabeled data is classified as associated with healthy or cancer samples and the top 20 data points are put back into the training set. The process continues until all have been appropriately classified. Three datasets were analyzed from Acute Lymphoblastic Leukemia (ALL), breast cancer and colorectal cancer. We obtained similar results for both supervised and semi-supervised classification. To improve our model, we assessed the functional landscape of gene fusion events and observed that the pathway neighbors of both gene fusion partners are differentially expressed in each cancer dataset. The significant neighbors are also shown to have direct connections to cancer pathways and functions, indicating that these gene fusions are important for cancer development. Future directions include applying the acquired transcriptomic knowledge to our machine learning algorithm, counting transcription factors and kinases within the gene fusion events and their neighbors and assessing the differences between upstream and downstream effects within the pathway neighbors.
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Lundqvist, Fredrik, and Martin Jarl. "En medial fusion : En studie av Telia-telenor fusionen." Thesis, Linköping University, Department of Management and Economics, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1460.

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Bakgrund: Telekomindustrin har på senare tiden genomgått en period av strukturella förändringar. Dessa strukturella förändringar har bland annat medfört fusioner och sammanslagningar av företag inom branschen. Fusioner har en inverkan på en rad olika faktorer för företag och samhällen. Att kommunicera med media är viktigt då ett företag genomgår en fusion.

Syfte: Syftet med denna magisteruppsats är att öka förståelsen för företags kommunikation under en fusion samt hur media reproducerar fusionen.

Metod: För att uppnå syftet med denna magisteruppsats genomfördes en diskursanalys av vad som skrivits om Telia-Telenor fusionen i media under 1999. Vi koncentrerade oss till stora svenska dagstidningar.

Resultat: Media fokuserade på fler aspekter i fusionen än vad de inblandade företagen tenderade att göra. På det sätt budskapen presenterades samt budskapens kontext hjälpte oss inte att uppnå en större förståelse för kommunikationen. Då både företag samt media var aktiva i debatten visade det sig att budskapens innehåll tenderade att skilja sig åt ju längre fusionen fortskred. Medierna var kraftigt influerade av en ekonomiskt rationell ideologi medan företagen tenderade att använda sig av flera olika ideologier. Aktörerna, media samt företagen, influerade eller påverkade inte varandra nämnvärt under fusionen. Dessa resultat har påvisat att media och företag befinner sig i två olika diskurser under en fusion.


Background: The telecommunications industry has recently been through a very changing structural period. Mergers have a significant impact on many societal aspects. Communication to the media is important during a merger.

Purpose: The aim of this thesis is to increase the understanding of corporations’ public communication in mergers and how the media reproduces it.

Method: In order to fulfil the purpose, we conducted a discourse analysis of mainly what has been written about the Telia-Telenor merger in the major Swedish newspapers in 1999.

Findings: The media focused on more aspects of the merger than the involved companies did. How messages were presented and in what context they occurred did not give us any higher understanding of the communication. When both the companies and the media were active in a topic their opinions tended to grow apart with time. The media were heavily influenced with rational financial ideology whereas the companies’ messages were influenced by a wider range of ideologies. The actors did not influence each other to any greater extent. This has lead us to believe that corporations and the media are in different discourses.

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Cemal, Hawar. "A31KAX: Fusion." Thesis, KTH, Arkitektur, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-95740.

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Målet är att skapa en mjuk övergång mellan bergsvägg och Hornsbruksgatan, genom en fusion mellan byggnadstypologi och topografi. Förenandet som skapas mellan gata leder till ökad cirkulation genom byggnaden.  Olika byggnadsdelar korsar varandra och integreras. Genom byggnadskorsningarna skapas det möjligheter för en programmix med ett trapphus som förenar park, bostad och kontor med gatan. Genom sluttande tak får man terrasser som följer topografin och leder  till utblickar mot söder, väster och öster. Här bildas spontana mötesplatser mellan boende, kontorsanställda och människor som passerar byggnaden för att ta sig till och från parken.
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Abu-Adas, Wael. "Highway fusion." Thesis, Massachusetts Institute of Technology, 1991. http://hdl.handle.net/1721.1/62898.

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Thesis (M. Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 1991.
Includes bibliographical references (p. 80-81).
The objective of this thesis Is to Investigate a design methodology that utilizes both visual perception and movement as determinants to design. We perceive and understand architecture and Its context by moving around it and walking through it. therefore our experience of architecture Is contingent on a sequence of visual and spatial events over a given time frame. Yet when we design. we seem to be primarily concerned with the relationship of static things and places to each other. with little consideration as to how we will perceive those relationships through movement. The context with which I have chosen to work is the highway. where speed and time play important roles. and where movement as a basis for design thinking would be most appropriate. This thesis looks at the highway as movement through space and as an experience Involving an enigmatic relationship among things and places as the driver moves through them. What Is sought Is a sequential visual experience consisting of landscape areas. scenic views. orientational land marks and visual events all of which work together to present us with a full and meaningful Image and experience of the context we are traversing. The three primary elements of the design are the perception of spatial organization. the sequencing of events. and a scale based on time. The project Is a welcoming center to Florida that acts as a "gateway· and an Initiating procession into the Sunshine State. This "gateway· is an Intense experiential journey that lasts Just over three minutes. Its form derives from an exploration of landscape as an Imagery for highway architecture.and of the relationships between landscape and the road. It is my attempt to incorporate the highway Into the landscape. rather than Imposing the highway on the landscape. This highway project Is Intended as a metaphor or model for further exploration into visual perception and movement that may be applied In other architectural designs. I am presently also working on computer animation. to simulate the driving experience through the design. Please check with my advisor for a copy of the video.
by Wael Abu-Adas.
M.Arch.
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Rudakova, N. O. "Talk Fusion." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/33802.

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With the rapid growth in technology nowadays there are numerous exciting gadgets being released on a daily basis. These technological innovations are meant to make our lives easier. Nowadays millions of people from all over the world use a lot of appliances, devices and gadgets. It means that there were a lot of changes in different areas such as education, communication and transport. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/33802
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White, David Maurice. "Pedagogical Fusion." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/993.

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During the five semesters that I have been at VCU I have learned a great deal from the courses that I have been enrolled in but I have learned the most through my experiences as a Teaching Assistant. These experiences have been so valuable because of the wide range of subject areas in which I have been involved and the diverse instructors that I have assisted. Although I hesitate to use the word "problem" I feel that there is a tendency in teacher training for a student to latch onto one professor and model their teaching practices after that one mentor. While this is not always a bad thing I feel that it can lead some students down a dead-end path of self-exploration and individualization of their personal teaching style. I feel that I have been given a rare and invaluable opportunity in that I have been permitted to assist so many different teachers in such a wide array of subjects. In this thesis, I propose to examine the widely varied experiences that I have had here at VCU as a Teacher and Teaching Assistant. I will look at the teaching styles that I have witnessed, the methodologies and approaches of each course, and most importantly I will put forth my personal teaching philosophy that I have developed from my experiences here at VCU.
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MacGregor, David S. "Fusion 2.0 the next generation of fusion in California : aligning state and regional fusion centers /." Thesis, Monterey, California : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/theses/2010/Mar/10Mar%5FMacGregor.pdf.

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Thesis (M.A. in Security Studies (Homeland Security and Defense))--Naval Postgraduate School, March 2010.
Thesis Advisor(s): Miller, Patrick ; Brannan, David. "March 2010." Author(s) subject terms: Fusion Centers, California, state, regional, role, mission, all crimes, all hazards, leadership, strategic, operational, intelligence needs, analysis, added value, relevant, customers, law enforcement, stakeholders, cooperation, interpersonal relationships, trust, collaboration, networks, synchronization, alignment, sustainability. Includes bibliographical references (p. 155-162). Also available in print.
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Bittner, Margot. "Enhancing the fusion method to fusionB requirements engineering and formal specification /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=980229839.

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Coutts, Duncan. "Stream fusion : practical shortcut fusion for coinductive sequence types." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b4971f57-2b94-4fdf-a5c0-98d6935a44da.

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In functional programming it is common practice to build modular programs by composing functions where the intermediate values are data structures such as lists or arrays. A desirable optimisation for programs written in this style is to fuse the composed functions and thereby eliminate the intermediate data structures and their associated runtime costs. Stream fusion is one such fusion optimisation that can eliminate intermediate data structures, including lists, arrays and other abstract data types that can be viewed as coinductive sequences. The fusion transformation can be applied fully automatically by a general purpose optimising compiler. The stream fusion technique itself has been presented previously and many practical implementations exist. The primary contributions of this thesis address the issues of correctness and optimisation: whether the transformation is correct and whether the transformation is an optimisation. Proofs of shortcut fusion laws have typically relied on parametricity by making use of free theorems. Unfortunately, most functional programming languages have semantics for which classical free theorems do not hold unconditionally; additional side conditions are required. In this thesis we take an approach based not on parametricity but on data abstraction. Using this approach we prove the correctness of stream fusion for lists -- encompassing the fusion system as a whole, not merely the central fusion law. We generalise this proof to give a framework for proving the correctness of stream fusion for any abstract data type that can be viewed as a coinductive sequence and give as an instance of the framework, a simple model of arrays. The framework requires that each fusible function satisfies a simple data abstraction property. We give proofs of this property for several standard list functions. Previous empirical work has demonstrated that stream fusion can be an optimisation in many cases. In this thesis we take a more universal view and consider the issue of optimisation independently of any particular implementation or compiler. We make a semi-formal argument that, subject to certain syntactic conditions on fusible functions, stream fusion on lists is strictly an improvement, as measured by the number of allocations of data constructors. This detailed analysis of how stream fusion works may be of use in writing fusible functions or in developing new implementations of stream fusion.
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Kangerud, Jim. "Sensor Fusion : Applying sensor fusion in a district heating substation." Thesis, Blekinge Tekniska Högskola, Avdelningen för för interaktion och systemdesign, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4884.

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Many machines in these days have sensors to collect information from the world they inhabit. The correctness of this information is crucial for the correct operation. However, at times sensors are not so reliable since they are sometimes affected of some type of noise and thus give incorrect information. Another drawback might be lack of information due to shortage of existing sensors. Sensor fusion is trying to overcome these drawbacks by integrating or combining information from multiple sensors. The heating of a building is a slow and time consuming process, i.e. either the flow or energy consumption are object to drastically changes. On the other hand, the tap water system, i.e. the heating of tap water can be the source to severe changes in both flow and energy consumption. This because of that the flow is stochastic in the tap water system, at any given time a tap may be opened or closed and therefore drastically change the flow. The purpose of this thesis is to investigate if is it possible to use sensor fusion to get accurate continuous flow values from a district heating substation. This is done by integrating different sensor fusion algorithms in a district heating substation simulator.
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Books on the topic "Fusion"

1

Morgan, Rochan. Fusion. New York: Urban, 2012.

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Malaysia, Pertubuhan Akitek, ed. Fusion. Penang: Pertubuhan Akitek Malaysia Northern Chapter, 2001.

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traducteur, Strim Laurent, Baggott Julianna, Baggott Julianna, and Baggott Julianna, eds. Fusion. [Montréal, Québec]: Flammarion Québec, 2013.

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Kirby, Rowan. Fusion. London: Mills& Boon, 1985.

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Rhenisch, Harold. Fusion. Toronto, Ont: Exile Editions, 1999.

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Kirby, Rowan. Fusion. London: Mills & Boon, 1985.

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Brahm, Laurence J. Fusion Economics. New York: Palgrave Macmillan US, 2014. http://dx.doi.org/10.1057/9781137444189.

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Herles, Wolfgang. Fusion: Roman. Hamburg: Hoffmann und Campe, 1999.

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Niu, Keishirō. Nuclear fusion. Cambridge [England]: Cambridge University Press, 1989.

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Li, Jinxing, Bob Zhang, and David Zhang. Information Fusion. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8976-5.

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Book chapters on the topic "Fusion"

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Dolan, Thomas J. "Nuclear Fusion Nuclear Fusion." In Encyclopedia of Sustainability Science and Technology, 7156–80. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0851-3_31.

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Lu, Lu, and Shibo Jiang. "Fusion." In Encyclopedia of AIDS, 1–9. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9610-6_62-1.

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Weik, Martin H. "fusion." In Computer Science and Communications Dictionary, 668. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_7842.

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Matsuoka, Takeshi, Motoji Yamamoto, Nobuhiro Ushimi, Jyun’ichi Inoue, Takuya Sugimoto, Manabu Araoka, Toshihiro Kiriki, Yuuki Yamaguchi, Tsutomu Hasegawa, and Akira Mohri. "Fusion." In RoboCup 2001: Robot Soccer World Cup V, 643–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-45603-1_103.

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Gooch, Jan W. "Fusion." In Encyclopedic Dictionary of Polymers, 331. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_5372.

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Gooch, Jan W. "Fusion." In Encyclopedic Dictionary of Polymers, 331. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_5373.

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Strawson, Galen. "The Second Fusion/Fusing the Fusions." In Stuff, Quality, Structure, 80–103. Oxford University PressOxford, 2024. http://dx.doi.org/10.1093/9780198903680.003.0006.

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Abstract Chapter 6 argues for Stoff ist Kraft, the view that there are no metaphysically fundamental distinctions to be made between the phenomena of force, energy, power, causation, physical law, and natural necessity. Some of these terms have genuinely different uses, but this does not support any sort of metaphysical separatism with respect to their fundamental being. The chapter then argues, with Nietzsche, for a further identity: there is no fundamental distinction between a thing and its power/force/energy features. To think otherwise is to succumb to a separatist, staticist conception of stuff: a thing’s power features must also be reckoned to be among its intrinsic qualities and so (by the argument of Chapter 5) as part of its total qualitiedness—with which it is identical. So too a thing’s behaviour is as much part of its fundamental being as anything about it that can’t be counted as its behaviour.
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Leeming, Mark. "Fusion–Fission–Fusion." In Equity and Law, 118–43. Cambridge University Press, 2019. http://dx.doi.org/10.1017/9781108367820.006.

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"Appendix A: Frequently Used Physical Constants." In Fusion, 237. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527629312.app1.

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"Appendix B: Energy Conversion Factors." In Fusion, 239. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527629312.app2.

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Conference papers on the topic "Fusion"

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Khandha, Ashutosh D., Sasidhar S. Vadapalli, Scott A. Holekamp, Vijay K. Goel, Christopher M. Bono, and Steve R. Garfin. "Quantifying Motion Across a Solid Lumbar Interbody Fusion Using a Finite Element Model." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-42954.

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Clinical assessment of pseudarthrosis or solid fusion is based on the residual motion across the “fused” segment (Kowalski et al, 2001). Dynamic flexion/extension (F/E) radiographs are commonly used to determine residual motion. Despite widespread use, it is unclear what the appropriate “cut-off” criteria to declare a fusion solid should be, with recommendations ranging from 0 to 5°. These values have not been derived by scientific methods. The present study was initiated to predict the angular sagittal motion across simulated lumbar interbody fusions (IF) using a Finite Element Model (FEM) of the ligamentous lumbar spinal segment. Anterior and posterior lumbar interbody fusions were simulated at the L3–L4 level as per the clinical procedure. Varying degrees of fusion were taken into account and the fusion mass was the simulated as a cancellous core with a cortical shell. The results indicated that 0.5° to 5.14° of angular motion can occur depending on fusion location and degree of completeness. While continuous bone might be noted at surgical exploration, this amount of motion may enable persistent loading of remaining structures, such as the annulus or spinal ligaments. In our view, this may prompt a redefinition of clinically “solid fusion”.
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Stakenborghs, Robert, and Jack Little. "Microwave Based NDE Inspection of HDPE Pipe Welds." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75742.

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This paper describes an innovative apparatus and method that has been developed to volumetrically examine dielectric materials, including high density polyethylene piping fusion joints. The method employs a first of a kind apparatus that is based on the creation of an image using electromagnetic energy in the microwave frequency range. The results of comprehensive laboratory testing and actual field inspection of HDPE thermal fusions using the microwave method and apparatus are presented. The specimens examined included both sound thermal fusions and those that included different types of internal flaws that commonly occur in industrial application. Through this research and field application, the apparatus has been shown capable of detecting the presence of internal flaws, such as lack of fusion (i.e. - cold fusion) and inclusions. Also, thickness changes and voids in the HDPE pipe base material were detected and imaged. The results of the NDE technique are compared to mechanical pull test validation. Finally, the scan images of the PE pipe thermal fusions are compared to theoretical fusion microstructure. Relationships between the HDPE fusion images and the basic fusion microstructure are developed.
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Pfeiffer, Ferris M., and Dennis L. Abernathie. "The Influence of Facet Fusion Strength on Instrumented Segment Range of Motion." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38082.

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Spinal fusion surgery is one of the most common surgical procedures used to alleviate lower back pain. It is estimated that between 200,000 and 300,000 spine fusion procedures performed each year in the United States [1]. There has been an increase of approximately 8% per year in the frequency of lumbar fusions in the United States since 1980 [2]. Spinal fusion is indicated for treatment of degenerative disk disease, degenerative joint disease, scoliosis, and isthmic and degenerative spondlylotisthesis when more conservative treatments have failed to achieve relief.
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O’Brien, Michael, Yifei Dai, and Glen L. Niebur. "Mechanical Validation of Computed Tomographic Quantification of Posterolateral Intertransverse Lumbar Fusion." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192279.

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The New Zealand White (NZW) rabbit is often used as an animal model in posterolateral intrertransverse lumbar fusions [1]. Qualitative measures, such as manual palpation and radiographs, have been used to assess fusion mass [1]. However, an evaluation by sacrifice and biomechanical testing is the gold standard for quantitative data. A non-invasive approach to quantitatively assess the mechanics of spinal fusion could allow longitudinal studies with decreased need for animal sacrifice.
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"Other Viewers." In 2018 International Conference on Information Fusion (FUSION). IEEE, 2018. http://dx.doi.org/10.23919/icif.2018.8455363.

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"Program." In 2018 International Conference on Information Fusion (FUSION). IEEE, 2018. http://dx.doi.org/10.23919/icif.2018.8455575.

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Mott, Katherine, and Jonathan Black. "Model-Based Heterogeneous Optimal Space Constellation Design." In 2018 International Conference on Information Fusion (FUSION). IEEE, 2018. http://dx.doi.org/10.23919/icif.2018.8455222.

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"Index." In 2018 International Conference on Information Fusion (FUSION). IEEE, 2018. http://dx.doi.org/10.23919/icif.2018.8455243.

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Ilin, Roman, and Galina L. Rogova. "Multi-Model Threat Assessment Involving Low Probability High Consequence Events." In 2018 International Conference on Information Fusion (FUSION). IEEE, 2018. http://dx.doi.org/10.23919/icif.2018.8454979.

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Meyer, Florian, Zhenyu Liu, and Moe Z. Win. "Network Localization and Navigation Using Measurements with Uncertain Origin." In 2018 International Conference on Information Fusion (FUSION). IEEE, 2018. http://dx.doi.org/10.23919/icif.2018.8455207.

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Reports on the topic "Fusion"

1

wu, ruiqing. Efficacy and Complications of Extreme Lateral Interbody Fusion (XLIF) for lumbar spinal stenosis：A Meta-Analysis and Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0085.

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Review question / Objective: P? Patients with Lumbar Spinal Stenosis. I? Extreme Lateral Interbody Fusion (XLIF). C? Other lumbar interbody fusions. O?Predefined outcome measures were preoperative and postoperative visual analogue scale back and/or leg pain (VAS-BP) and Oswestry Disability Index (ODI) score; operation time; intraoperative blood loss; length of hospital stay; and the complications, reoperation and fusion rate. S: randomized controlled trials (RCTs) or nonrandomized cohort studies. Condition being studied: Extreme Lateral Interbody Fusion (XLIF) can be widely used for the treatment of lumbar spinal stenosis, and this study aims to summarize the efficacy and complications of this procedure for lumbar spinal stenosis. Extreme Lateral Interbody Fusion (XLIF) for the treatment of Lumbar Spinal Stenosis.for the treatment of lumbar spinal stenosis, and this study aims to summarize the efficacy and complications of this procedure for lumbar spinal stenosis.Extreme Lateral Interbody Fusion (XLIF) for the treatment of Lumbar Spinal Stenosis.
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Parsons, Jean Louise, and Kristen Deanne Morris. Floral Fusion. Ames (Iowa): Iowa State University. Library, January 2019. http://dx.doi.org/10.31274/itaa.9545.

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J.A. Schmidt. Fusion Implementation. Office of Scientific and Technical Information (OSTI), February 2002. http://dx.doi.org/10.2172/796127.

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Langendorf, Samuel. Fusion / LANL. Office of Scientific and Technical Information (OSTI), November 2020. http://dx.doi.org/10.2172/1716771.

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L.E. Zakharov. LiWall Fusion - The New Concept of Magnetic Fusion. Office of Scientific and Technical Information (OSTI), January 2011. http://dx.doi.org/10.2172/1001686.

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Biener, J., C. Dawedeit, A. A. Chernov, M. A. Worsley, S. H. Kim, J. I. Lee, T. M. Willey, et al. Fusion Application Targets. Office of Scientific and Technical Information (OSTI), December 2010. http://dx.doi.org/10.2172/1124944.

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Wurden, Glen A., Scott C. Hsu, Thomas P. Intrator, C. Grabowski, M. Domonkos, Peter J. Turchi, M. Herrmann, et al. Magneto-Inertial Fusion. Office of Scientific and Technical Information (OSTI), May 2014. http://dx.doi.org/10.2172/1133762.

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Hansen, Stephanie B. Magneto-inertial Fusion. Office of Scientific and Technical Information (OSTI), July 2015. http://dx.doi.org/10.2172/1202011.

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Hsu, Scott C. Magnetoinertial fusion (MIF). Office of Scientific and Technical Information (OSTI), July 2013. http://dx.doi.org/10.2172/1088359.

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Powers, L., R. Condouris, and M. Kotowski. Inertial confinement fusion. Edited by P. W. Murphy. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/6456354.

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