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Journal articles on the topic 'FUS imaging'

Author: Grafiati

Published: 28 September 2024

Last updated: 31 July 2025

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1

Hugon, Gaëlle, Sébastien Goutal, Ambre Dauba, et al. "[18F]2-Fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Monitoring of Enhanced Blood-Brain Barrier Permeability Induced by Focused Ultrasound." Pharmaceutics 13, no. 11 (2021): 1752. http://dx.doi.org/10.3390/pharmaceutics13111752.

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Focused ultrasound in combination with microbubbles (FUS) provides an effective means to locally enhance the delivery of therapeutics to the brain. Translational and quantitative imaging techniques are needed to noninvasively monitor and optimize the impact of FUS on blood-brain barrier (BBB) permeability in vivo. Positron-emission tomography (PET) imaging using [18F]2-fluoro-2-deoxy-sorbitol ([18F]FDS) was evaluated as a small-molecule (paracellular) marker of blood-brain barrier (BBB) integrity. [18F]FDS was straightforwardly produced from chemical reduction of commercial [18F]2-deoxy-2-fluo

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Bastiancich, Chiara, Samantha Fernandez, Florian Correard, et al. "Molecular Imaging of Ultrasound-Mediated Blood-Brain Barrier Disruption in a Mouse Orthotopic Glioblastoma Model." Pharmaceutics 14, no. 10 (2022): 2227. http://dx.doi.org/10.3390/pharmaceutics14102227.

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Glioblastoma (GBM) is an aggressive and malignant primary brain tumor. The blood-brain barrier (BBB) limits the therapeutic options available to tackle this incurable tumor. Transient disruption of the BBB by focused ultrasound (FUS) is a promising and safe approach to increase the brain and tumor concentration of drugs administered systemically. Non-invasive, sensitive, and reliable imaging approaches are required to better understand the impact of FUS on the BBB and brain microenvironment. In this study, nuclear imaging (SPECT/CT and PET/CT) was used to quantify neuroinflammation 48 h post-F

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3

Xu, Lu, Yan Gong, Chih-Yen Chien, and Hong Chen. "Shaveless focused-ultrasound-induced blood-brain barrier opening in mice." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A140. http://dx.doi.org/10.1121/10.0018435.

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To demonstrate that focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) in mice can be achieved without shaving hairs. We performed FUS-BBBO in mice by using oil as the coupling medium without shaving hairs. The hydrophobic nature of oil leads to a higher affinity to hair than water-based ultrasound gel. FUS-BBBO outcome was compared under three conditions: “oil + hairs,” “gel + hairs,” and “gel + no hairs.” T2-weighted, T1-weighted MRI, and fluorescence imaging of the ex vivo brain slices were performed to measure the quality of coupling and outcome of FUS-BBBO. Results showed t

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Soloukey, S., E. Collée, L. Verhoef, et al. "P15.07.B FUNCTIONAL BRAIN MAPPING DURING AWAKE TUMOR RESECTIONS USING ESM-FMRI CO-REGISTERED FUNCTIONAL ULTRASOUND (FUS)-IMAGING." Neuro-Oncology 25, Supplement_2 (2023): ii110—ii111. http://dx.doi.org/10.1093/neuonc/noad137.371.

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Abstract BACKGROUND Neurosurgical resection of brain tumors resembles a balancing act between maximing extent of tumor resection (efficacy) and minimizing the risk of post-operative neurological deficits (safety). Given the difficulty of this trade-off, it is surprising how limited the neurosurgeon’s intra-operative tools are. To this day, neurosurgeons still resect brain tumors without any form of real-time volumetric functional imaging. Functional Ultrasound (fUS) shows great potential as a next-generation intra-operative functional imaging technique, combining submillimeter-subsecond spatio

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Xu, Zhouyang, Samuel Pichardo, and Bingbing Cheng. "Enhancement of brain hyperthermia via transcranial magnetic resonance imaging-guided focused ultrasound and microbubbles—Heating mechanism investigation using COMSOL." Journal of the Acoustical Society of America 154, no. 4_supplement (2023): A279. http://dx.doi.org/10.1121/10.0023523.

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Noninvasive methods for enhancing the brain drug delivery has been pursued for years. Previously we developed a new MR-guided focused ultrasound (FUS)-based technique, which can achieve targeted brain hyperthermia for heat-triggered drug release and simultaneously open the blood–brain barrier safely for drug penetration. However, the underline mechanisms were unclear. This study aimed to explore the mechanisms for the enhanced FUS brain tissue hyperthermia with microbubbles via numerical modeling in COMSOL. The acoustic wave equation was employed to describe the FUS propagation. A bubble dynam

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Wang, Tony R., Aaron E. Bond, Robert F. Dallapiazza, et al. "Transcranial magnetic resonance imaging–guided focused ultrasound thalamotomy for tremor: technical note." Neurosurgical Focus 44, no. 2 (2018): E3. http://dx.doi.org/10.3171/2017.10.focus17609.

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Although the use of focused ultrasound (FUS) in neurosurgery dates to the 1950s, its clinical utility was limited by the need for a craniotomy to create an acoustic window. Recent technological advances have enabled efficient transcranial delivery of US. Moreover, US is now coupled with MRI to ensure precise energy delivery and monitoring. Thus, MRI-guided transcranial FUS lesioning is now being investigated for myriad neurological and psychiatric disorders. Among the first transcranial FUS treatments is thalamotomy for the treatment of various tremors. The authors provide a technical overview

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Gagliardo, Cesare, Roberto Cannella, Costanza D’Angelo, et al. "Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound with a 1.5 Tesla Scanner: A Prospective Intraindividual Comparison Study of Intraoperative Imaging." Brain Sciences 11, no. 1 (2021): 46. http://dx.doi.org/10.3390/brainsci11010046.

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Background: High-quality intraoperative imaging is needed for optimal monitoring of patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy. In this paper, we compare the intraoperative imaging obtained with dedicated FUS-Head coil and standard body radiofrequency coil in tcMRgFUS thalamotomy using 1.5-T MR scanner. Methods: This prospective study included adult patients undergoing tcMRgFUS for treatment of essential tremor. Intraoperative T2-weighted FRFSE sequences were acquired after the last high-energy sonication using a dedicated two-channel FUS-Head (2ch-FUS

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Sheybani, Natasha, Soumen Paul, Katelyenn McCauley, et al. "472 ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A502—A503. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0472.

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BackgroundThe natural disease course for glioblastoma (GB) entails invariably grim outcomes for patients. Phagocytic immunotherapies, such as CD47 blockade (e.g. mCD47), have recently demonstrated promise for GB therapy. However, their efficacy is challenged by presence of the blood brain and tumor barriers (BBB/BTB). Transient disruption of the BBB/BTB via focused ultrasound (FUS) and circulating microbubbles (MB) holds promise for improving therapeutic outcomes in the context of mCD47. However, critical questions regarding the optimal protocol for therapeutic antibody delivery with FUS remai

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9

Thanou, M., and W. Gedroyc. "MRI-Guided Focused Ultrasound as a New Method of Drug Delivery." Journal of Drug Delivery 2013 (May 12, 2013): 1–12. http://dx.doi.org/10.1155/2013/616197.

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Ultrasound-mediated drug delivery under the guidance of an imaging modality can improve drug disposition and achieve site-specific drug delivery. The term focal drug delivery has been introduced to describe the focal targeting of drugs in tissues with the help of imaging and focused ultrasound. Focal drug delivery aims to improve the therapeutic profile of drugs by improving their specificity and their permeation in defined areas. Focused-ultrasound- (FUS-) mediated drug delivery has been applied with various molecules to improve their local distribution in tissues. FUS is applied with the aid

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Zhang, Junhang, Chen Gong, Zihan Yang, et al. "Ultrasound Flow Imaging Study on Rat Brain with Ultrasound and Light Stimulations." Bioengineering 11, no. 2 (2024): 174. http://dx.doi.org/10.3390/bioengineering11020174.

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Functional ultrasound (fUS) flow imaging provides a non-invasive method for the in vivo study of cerebral blood flow and neural activity. This study used functional flow imaging to investigate rat brain’s response to ultrasound and colored-light stimuli. Male Long-Evan rats were exposed to direct full-field strobe flashes light and ultrasound stimulation to their retinas, while brain activity was measured using high-frequency ultrasound imaging. Our study found that light stimuli, particularly blue light, elicited strong responses in the visual cortex and lateral geniculate nucleus (LGN), as e

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Fadera, Siaka, Chinwendu Chukwu, Andrew H. Stark, et al. "DDEL-11. FOCUSED ULTRASOUND-MEDIATED DELIVERY OF ANTI-PROGRAMMED CELL DEATH-LIGAND 1 ANTIBODY TO THE BRAIN OF A PORCINE MODEL." Neuro-Oncology 25, Supplement_5 (2023): v103. http://dx.doi.org/10.1093/neuonc/noad179.0390.

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Abstract Focused ultrasound-combined with microbubble-mediated blood-brain barrier opening (FUS-BBBO) has been established as a promising brain drug delivery technology for the treatment of brain tumors. Immune checkpoint inhibitor therapy is a form of cancer immunotherapy that has revolutionized the treatment of cancer and shown remarkable efficacy in a range of cancers. Previous studies reported successful delivery of a checkpoint inhibitor anti-PD-L1 antibody (aPD-L1) by FUS-BBBO in the mouse brain. The objective of this study was to evaluate the feasibility and safety of FUS-BBBO in the de

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Soloukey, S., L. Verhoef, F. Mastik, et al. "P09.03 Fully integrating functional Ultrasound (fUS) into the onco-neurosurgical operating room: Towards a new real-time, high-resolution image-guided resection tool with multimodal potential." Neuro-Oncology 23, Supplement_2 (2021): ii26—ii27. http://dx.doi.org/10.1093/neuonc/noab180.091.

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Abstract BACKGROUND Onco-neurosurgical practice still relies heavily on pre-operatively acquired images to guide intra-operative decision-making for safe tumor removal, a practice with inherent pitfalls such as registration inaccuracy due to brain shift, and lack of real-time (functional) feedback. Exploiting the opportunity for real-time imaging of the exposed brain can improve intra-operative decision-making, neurosurgical safety and patient outcomes. Previously, we described functional Ultrasound (fUS) as a high-resolution, depth-resolved imaging technique able to detect functional regions

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13

Maslova, Stefanyda, Zehra Demir, Thomas Sherlock, et al. "MDB-108. MRI-GUIDED FOCUSED ULTRASOUND BLOOD BRAIN/TUMOR BARRIER DISRUPTION FOR AUGMENTATION OF ANTIBODY DELIVERY TO HIGH-RISK MEDULLOBLASTOMAS." Neuro-Oncology 26, Supplement_4 (2024): 0. http://dx.doi.org/10.1093/neuonc/noae064.556.

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Abstract BACKGROUND Medulloblastoma is the most common pediatric brain cancer, and among its four molecular subgroups, group 3 (G3MB) harbors the worst prognosis (5-year survival rate &lt;50%). Effective treatment of G3MB remains difficult due to disease complexity, its challenging niche within the immunologically- and pharmacologically-privileged central nervous system, and significant risk of long-term developmental deficits due to treatment toxicities. MRI-guided focused ultrasound (MRgFUS) holds the potential to revolutionize care as a non-invasive, non-ionizing approach for spatially

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Nayak, Rohit, Jeyeon Lee, Setayesh Sotoudehnia, Su-Youne Chang, Mostafa Fatemi, and Azra Alizad. "Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study." Sensors 23, no. 15 (2023): 6902. http://dx.doi.org/10.3390/s23156902.

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Functional ultrasound (fUS), an emerging hemodynamic-based functional neuroimaging technique, is especially suited to probe brain activity and primarily used in animal models. Increasing use of pharmacological models for essential tremor extends new research to the utilization of fUS imaging in such models. Harmaline-induced tremor is an easily provoked model for the development of new therapies for essential tremor (ET). Furthermore, harmaline-induced tremor can be suppressed by the same classic medications used for essential tremor, which leads to the utilization of this model for preclinica

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Edelman, Bradley J., Dominique Siegenthaler, Paulina Wanken, et al. "The COMBO window: A chronic cranial implant for multiscale circuit interrogation in mice." PLOS Biology 22, no. 6 (2024): e3002664. http://dx.doi.org/10.1371/journal.pbio.3002664.

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Neuroscientists studying the neural correlates of mouse behavior often lack access to the brain-wide activity patterns elicited during a specific task of interest. Fortunately, large-scale imaging is becoming increasingly accessible thanks to modalities such as Ca2+ imaging and functional ultrasound (fUS). However, these and other techniques often involve challenging cranial window procedures and are difficult to combine with other neuroscience tools. We address this need with an open-source 3D-printable cranial implant—the COMBO (ChrOnic Multimodal imaging and Behavioral Observation) window.

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16

Chu, Po-Chun, Wen-Yen Chai, Han-Yi Hsieh, et al. "Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors." BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/627496.

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Microbubble-enhanced focused ultrasound (FUS) can enhance the delivery of therapeutic agents into the brain for brain tumor treatment. The purpose of this study was to investigate the influence of brain tumor conditions on the distribution and dynamics of small molecule leakage into targeted regions of the brain after FUS-BBB opening. A total of 34 animals were used, and the process was monitored by 7T-MRI. Evans blue (EB) dye as well as Gd-DTPA served as small molecule substitutes for evaluation of drug behavior. EB was quantified spectrophotometrically. Spin-spin (R1) relaxometry and area un

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Montaldo, Gabriel, Alan Urban, and Emilie Macé. "Functional Ultrasound Neuroimaging." Annual Review of Neuroscience 45, no. 1 (2022): 491–513. http://dx.doi.org/10.1146/annurev-neuro-111020-100706.

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Functional ultrasound (fUS) is a neuroimaging method that uses ultrasound to track changes in cerebral blood volume as an indirect readout of neuronal activity at high spatiotemporal resolution. fUS is capable of imaging head-fixed or freely behaving rodents and of producing volumetric images of the entire mouse brain. It has been applied to many species, including primates and humans. Now that fUS is reaching maturity, it is being adopted by the neuroscience community. However, the nature of the fUS signal and the different implementations of fUS are not necessarily accessible to nonspecialis

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Blaize, Kévin, Fabrice Arcizet, Marc Gesnik, et al. "Functional ultrasound imaging of deep visual cortex in awake nonhuman primates." Proceedings of the National Academy of Sciences 117, no. 25 (2020): 14453–63. http://dx.doi.org/10.1073/pnas.1916787117.

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Deep regions of the brain are not easily accessible to investigation at the mesoscale level in awake animals or humans. We have recently developed a functional ultrasound (fUS) technique that enables imaging hemodynamic responses to visual tasks. Using fUS imaging on two awake nonhuman primates performing a passive fixation task, we constructed retinotopic maps at depth in the visual cortex (V1, V2, and V3) in the calcarine and lunate sulci. The maps could be acquired in a single-hour session with relatively few presentations of the stimuli. The spatial resolution of the technology is illustra

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Hoque, Nazia, Choudhury Hasan, Md Rana, Amrit Varsha, Md Sohrab, and Khondaker Rahman. "Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines." Molecules 23, no. 12 (2018): 3288. http://dx.doi.org/10.3390/molecules23123288.

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As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a Fusarium solani strain, which is associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC50 against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.

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Zhang, Xinrui, Mariana Bobeica, Michael Unger, et al. "Focused ultrasound radiosensitizes human cancer cells by enhancement of DNA damage." Strahlentherapie und Onkologie 197, no. 8 (2021): 730–43. http://dx.doi.org/10.1007/s00066-021-01774-5.

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Abstract Purpose High-intensity focused ultrasound (HIFU/FUS) has expanded as a noninvasive quantifiable option for hyperthermia (HT). HT in a temperature range of 40–47 °C (thermal dose CEM43 ≥ 25) could work as a sensitizer to radiation therapy (RT). Here, we attempted to understand the tumor radiosensitization effect at the cellular level after a combination treatment of FUS+RT. Methods An in vitro FUS system was developed to induce HT at frequencies of 1.147 and 1.467 MHz. Human head and neck cancer (FaDU), glioblastoma (T98G), and prostate cancer (PC-3) cells were exposed to FUS in ultras

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Wei, Kuochen, Koting Chen, and Chiungyin Huang. "CTNI-35. EVALUATE THE SAFETY AND PRELIMINARY EFFICACY OF THE COMBINATION OF NAVIFUS SYSTEM WITH RE-IRRADIATION FOR RGBM PATIENTS." Neuro-Oncology 26, Supplement_8 (2024): viii104. http://dx.doi.org/10.1093/neuonc/noae165.0402.

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Abstract The blood-brain barrier (BBB) remains the major obstacle in treating patients with malignant brain tumors. Radiation therapy (RT) is the mainstay adjuvant modality regardless of the BBB, but its effectiveness is hindered by the hypoxic microenvironment. Focused ultrasound (FUS) combined with systemic microbubbles has been shown to open the BBB and potentially increase regional perfusion. However, no clinical study has investigated the combination of RT with FUS-BBB opening (RT-FUS). Here, we report an interim analysis of an ongoing single-arm, prospective, pilot study (NCT04988750) co

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Sharma, Deepa, Farah Hussein, Niki Law, et al. "Focused Ultrasound Stimulation of Microbubbles in Combination With Radiotherapy for Acute Damage of Breast Cancer Xenograft Model." Technology in Cancer Research & Treatment 21 (January 2022): 153303382211329. http://dx.doi.org/10.1177/15330338221132925.

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Objective: Several studies have focused on the use of ultrasound-stimulated microbubbles (USMB) to induce vascular damage in order to enhance tumor response to radiation. Methods: In this study, power Doppler imaging was used along with immunohistochemistry to investigate the effects of combining radiation therapy (XRT) and USMB using an ultrasound-guided focused ultrasound (FUS) therapy system in a breast cancer xenograft model. Specifically, MDA-MB-231 breast cancer xenograft tumors were induced in severe combined immuno-deficient female mice. The mice were treated with FUS alone, ultrasound

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Ishigaki, Shinsuke, Yuichi Riku, Yusuke Fujioka, et al. "Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases." Brain 143, no. 8 (2020): 2398–405. http://dx.doi.org/10.1093/brain/awaa196.

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Abstract Fused in sarcoma (FUS) is genetically and clinicopathologically linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). We have previously reported that intranuclear interactions of FUS and splicing factor, proline- and glutamine-rich (SFPQ) contribute to neuronal homeostasis. Disruption of the FUS-SFPQ interaction leads to an increase in the ratio of 4-repeat tau (4R-tau)/3-repeat tau (3R-tau), which manifests in FTLD-like phenotypes in mice. Here, we examined FUS-SFPQ interactions in 142 autopsied individuals with FUS-related ALS/FTLD (ALS/FTLD-FU

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Tazhibi, Masih, Nicholas McQuillan, Hong-Jian Wei, et al. "RADT-17. FOCUSED ULTRASOUND MEDIATED BLOOD–BRAIN BARRIER OPENING IS SAFE AND FEASIBLE CONCURRENT WITH AND ADJUVANT TO A CLINICAL RADIATION SCHEME FOR BRAINSTEM DMG." Neuro-Oncology 23, Supplement_6 (2021): vi44—vi45. http://dx.doi.org/10.1093/neuonc/noab196.175.

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Abstract Diffuse midline gliomas (DMG) are pediatric tumors with dismal prognosis. When these tumors emerge in the brainstem, there exists no feasible method of surgical resection or systemic intervention, making ionizing radiation the sole therapeutic avenue to date. However, radiotherapy (RT) provides only marginal survival benefit as the topographically diffuse and highly infiltrative tumors spread in areas in which the blood-brain barrier (BBB) is relatively intact. Focused ultrasound (FUS) with intravenous microbubbles provides a compelling solution, transiently and non-invasively opening

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Fukunishi, H., K. Funaki, K. Ikuma, et al. "Unsuspected uterine leiomyosarcoma: magnetic resonance imaging findings before and after focused ultrasound surgery." International Journal of Gynecologic Cancer 17, no. 3 (2007): 724–28. http://dx.doi.org/10.1136/ijgc-00009577-200705000-00025.

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Uterine leiomyosarcoma, initially diagnosed as leiomyoma on magnetic resonance (MR) images, was disclosed after focused ultrasound surgery (FUS). The tumor did not display high signal intensity on either T1- or T2-weighted images on the patient's first visit. Four months thereafter, T2-weighted images revealed a high signal intensity area within the tumor, while T1-weighted images showed low signal intensity. Six months after FUS, the nonperfused volume calculated on meglumine gadoterate-enhanced T1-weighted images decreased markedly and an intermediate signal intensity in a circular area on T

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Fadera, Siaka, Lu Xu, Chih-Yen Chien, et al. "Feasibility of MRI-guided focused ultrasound-mediated intranasal delivery in a large animal model." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A139. http://dx.doi.org/10.1121/10.0018430.

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Intranasal delivery provides non-invasive delivery of drugs from the nose to the brain bypassing the blood-brain barrier (BBB). We previously reported the focused ultrasound (FUS)-mediated intranasal delivery (FUSIN) of various agents in mice using FUS. However, no study has investigated the feasibility of FUSIN in large animals. The objective of this study was to investigate the feasibility of MR-guided FUS-mediated intranasal delivery in a large animal model. Pigs were used as the large animal model due to their clinical relevance to humans. Fluorescence-labeled albumin was mixed with an MRI

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Fadera, Siaka. "Focused ultrasound-mediated delivery of anti-programmed cell death-ligand 1 antibody to the brain of a porcine model." Journal of the Acoustical Society of America 154, no. 4_supplement (2023): A224. http://dx.doi.org/10.1121/10.0023352.

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Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer treatment by leveraging the body's immune system to combat cancer cells. However, its effectiveness in brain cancer is hindered by the blood-brain barrier (BBB), impeding the delivery of ICIs to brain tumor cells. This study aimed to assess the safety and feasibility of using focused ultrasound combined with microbubbles-mediated BBB opening (FUS-BBBO) to facilitate trans-BBB delivery of an ICI, anti-programmed cell death-ligand 1 antibody (aPD-L1), to the brain of a large animal model. In a porcine model, FUS sonication of ta

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Fadera, Siaka, Chinwendu Chukwu, Andrew H. Stark, et al. "Focused Ultrasound-Mediated Delivery of Anti-Programmed Cell Death-Ligand 1 Antibody to the Brain of a Porcine Model." Pharmaceutics 15, no. 10 (2023): 2479. http://dx.doi.org/10.3390/pharmaceutics15102479.

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Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer treatment by leveraging the body’s immune system to combat cancer cells. However, its effectiveness in brain cancer is hindered by the blood-brain barrier (BBB), impeding the delivery of ICIs to brain tumor cells. This study aimed to assess the safety and feasibility of using focused ultrasound combined with microbubble-mediated BBB opening (FUS-BBBO) to facilitate trans-BBB delivery of an ICI, anti-programmed cell death-ligand 1 antibody (aPD-L1) to the brain of a large animal model. In a porcine model, FUS sonication of targ

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Sheybani, Natasha D. "Emerging applications of image-guided therapeutic ultrasound for brain tumor-directed immunomodulation and immunotherapy." Journal of the Acoustical Society of America 152, no. 4 (2022): A154. http://dx.doi.org/10.1121/10.0015866.

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Immunotherapy has been established as a disruptive pillar of cancer treatment. However, the impact of immunotherapy has yet to be fully realized in neuro-oncology owing to the unique physical barriers (i.e., blood brain/tumor barriers [BBB/BTB]) and distinct immune microenvironment within brain tumors. These obstacles may be overcome through the alliance of image-guided interventions, such as therapeutic ultrasound, with immunotherapies. Specifically, transient disruption of the BBB/BTB via focused ultrasound (FUS) and circulating microbubbles is a promising strategy for potentiating immunothe

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Lipsman, Nir. "Focused ultrasound in the human brain: Current and emerging applications." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A100. http://dx.doi.org/10.1121/10.0018301.

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MR-guided Focused ultrasound (MRgFUS) is a disruptive medical technology, and its implementation in the clinic represents the culmination of decades of research. Lying at the convergence of physics, engineering, imaging, biology and neuroscience, FUS offers the ability to non-invasively and precisely intervene in key circuits that drive common and challenging brain conditions. The actions of FUS in the brain take many forms, ranging from transient blood-brain barrier opening to permanent thermoablation, among other mechanisms. The last decade has seen a dramatic expansion of indications for an

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Soloukey, Sadaf, Arnaud J. P. E. Vincent, Djaina D. Satoer, et al. "NIMG-19. USING FUNCTIONAL ULTRASOUND (FUS) TO MAP BRAIN FUNCTIONALITY AND TUMOR VASCULATURE WITH MICROMETER-MILLISECOND PRECISION." Neuro-Oncology 22, Supplement_2 (2020): ii151. http://dx.doi.org/10.1093/neuonc/noaa215.632.

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Abstract OBJECTIVE In the early 20th century, Dr. Cushing first demonstrated the use of electrical stimulation mapping (ESM) to define motor and sensory cortices during neurosurgical procedures. Essentially, little has changed in what guides a neurosurgeon’s intra-operative decision-making since. Inherent limitations of ESM such as limited depth penetration and risk of seizure elicitation, warrant the development of new image-guided resection tools. Here, we present functional Ultrasound (fUS)-imaging as a new, high-resolution tool to guide intra-operative decision-making during awake tumor re

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Chen, Mark, Eric S. Xu, Nathan H. Leisenring, et al. "The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice." Sarcoma 2019 (July 25, 2019): 1–14. http://dx.doi.org/10.1155/2019/1340261.

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Myxoid liposarcoma is a malignant soft tissue sarcoma characterized by a pathognomonic t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. Here, we report the generation and characterization of a spatially and temporally restricted mouse model of sarcoma driven by FUS-CHOP. Using different Cre drivers in the adipocyte lineage, we initiated in vivo tumorigenesis by expressing FUS-CHOP in Prrx1+ mesenchymal progenitor cells. In contrast, expression of FUS-CHOP

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Le, Binh Thanh, and R. N. Taylor. "Ground response to tunnelling incorporating soil reinforcement system." Canadian Geotechnical Journal 56, no. 11 (2019): 1719–28. http://dx.doi.org/10.1139/cgj-2018-0075.

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The forepole umbrella system (FUS) uses steel pipes installed from within a tunnel to provide a canopy above the tunnel heading that both increases stability and reduces tunnelling-induced ground movements. Although the system is known to be beneficial and has been used in a number of projects, there is little information on how key parameters including length and forepole stiffness combine to produce effective support. To investigate this, centrifuge tests incorporating the three-dimensional (3D) geometry of a tunnel heading in clay and the model FUS have been undertaken. The tunnel heading w

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Soloukey, Sadaf, Luuk Verhoef, Frits Mastik, et al. "ITVT-10. Using functional Ultrasound (fUS) for real-time, depth-resolved functional and vascular delineation of brain tumors with micrometer-millisecond precision." Neuro-Oncology 23, Supplement_6 (2021): vi230. http://dx.doi.org/10.1093/neuonc/noab196.921.

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Abstract BACKGROUND Neurosurgical practice still relies heavily on pre-operatively acquired images to guide tumor resections, a practice which comes with inherent pitfalls such as registration inaccuracy due to brain shift, and lack of real-time functional or morphological feedback. Here we describe functional Ultrasound (fUS) as a new high-resolution, depth-resolved, MRI/CT-registered imaging technique able to detect functional regions and vascular morphology during awake and anesthesized tumor resections. MATERIALS AND METHODS fUS relies on high-frame-rate (HFR) ultrasound, making the techni

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Claxton, Amelia, Paul Cressey, David Thurston, et al. "Abstract 3948: Enhancing immune checkpoint delivery to diffuse midline glioma (DMG) using focused ultrasound." Cancer Research 85, no. 8_Supplement_1 (2025): 3948. https://doi.org/10.1158/1538-7445.am2025-3948.

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Brain tumors, such as diffuse midline glioma (DMG), remain the leading cause of cancer-related death in pediatric oncology due to their universal fatality and limited treatment options. Treatment of DMG is hindered by the blood-brain barrier (BBB) presenting a roadblock in the clinical translation of therapies, particularly for larger therapeutic agents such as antibodies (e.g., immune checkpoint inhibitors). Focused ultrasound (FUS) and cavitating microbubbles provide a solution to this by transiently disrupting the BBB in a controlled and safe manner, allowing significantly enhanced drug del

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Yeingst, Tyus J., Angelica M. Helton, Ferdousi S. Rawnaque, et al. "Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration." Gels 11, no. 2 (2025): 120. https://doi.org/10.3390/gels11020120.

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An ultrasound-responsive hydrogel system was developed that provides on-demand release when stimulated by focused ultrasound (fUS). Diels–Alder cycloadducts crosslinked polyethylene glycol (PEG) hydrogels and underwent a retrograde Diels–Alder reaction when exposed to fUS. Four-arm and eight-arm furan-based Diels–Alder hydrogel compositions were used to evaluate the link between the crosslinking density and the fUS-induced release and retention rates. PEG crosslinked with glutaraldehyde was also used as a non-Diels–Alder control hydrogel. By increasing the exposure time and the amplitude of fU

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Morgan-Curtis, Fea, Lucas Ruge-Jones, Grace M. Wood, et al. "Ultrasound diagnosis and treatment of heterotopic ossification." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A326. http://dx.doi.org/10.1121/10.0027686.

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Heterotopic ossification (HO), or the presence of bone in soft tissues, can occur after musculoskeletal trauma, causing pain and reduced mobility. However, even the most sensitive diagnostic modality requires 2–3 weeks after initiation to detect HO, and the only treatment is surgical resection after HO matures (&gt;2 years). Here, we evaluate the color Doppler ultrasound twinkling artifact for early diagnosis of HO and focused ultrasound (fUS) for treatment of early HO. We began by evaluating twinkling and fUS parameters in ossified cell culture. We then evaluated imaging and treatment par

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Price, Richard J. "Promoting immunotherapy of cancer with focused ultrasound." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A99. http://dx.doi.org/10.1121/10.0018300.

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Immunotherapy (ITx) has revolutionized cancer treatment. Nonetheless, for several indications, many patients do not respond to ITx due to poor immune cell infiltration and/or limited ITx penetration into solid tumors. Both thermally ablative (T) and mechanical (M) forms of focused ultrasound (FUS) may be capable of overcoming these challenges. For example, the pre-clinical application of T-FUS in combination with myeloreductive gemcitabine elicits immunological control of 4T1 breast tumors and metastases, results that inspired the Br54 clinical trial for early stage breast cancer patients at U

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Woldegerima, Ayda, Hong-Jian Wei, Chunchao Zhang, et al. "DIPG-73. FOCUSED ULTRASOUND FOR TREATMENT OF CHILDREN DIAGNOSED WITH DIFFUSE MIDLINE GLIOMAS." Neuro-Oncology 26, Supplement_4 (2024): 0. http://dx.doi.org/10.1093/neuonc/noae064.126.

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Abstract BACKGROUND Diffuse midline glioma (DMG) is a highly aggressive and fatal brain tumor that predominantly impacts children and young adults. The infiltrative pattern and rapid growth characteristics of DMG causes a significant challenge in finding an effective treatment. Additionally, the blood-brain barrier (BBB) poses a significant challenge by restricting the passage of therapeutic drugs to tumor bed. Currently the established standard of care is radiotherapy (RT), which is transitory. Thus there is a need for improved treatment options. OBJECTIVE Focused ultrasound (FUS) is an advan

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Yang, Andrew I., Hanane Chaibainou, Sumei Wang, et al. "Focused Ultrasound Thalamotomy for Essential Tremor in the Setting of a Ventricular Shunt: Technical Report." Operative Neurosurgery 17, no. 4 (2019): 376–81. http://dx.doi.org/10.1093/ons/opz013.

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Abstract BACKGROUND A recent randomized controlled trial of magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) for essential tremor (ET) demonstrated safety and efficacy. Patients with ventricular shunts may be good candidates for FUS to minimize hardware-associated infections. OBJECTIVE To demonstrate feasibility of FUS in this subset of patients. METHODS A 74-yr-old male with medically refractory ET, and a right-sided ventricular shunt for normal pressure hydrocephalus, underwent FUS to the right ventro-intermedius (VIM) nucleus. The VIM nucleus was directly targeted using dete

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Wei, Hong-Jian, Antonios Pouliopoulos, Nina Yoh, et al. "EPCT-23 PRE-CLINICAL STUDY OF FOCUSED ULTRASOUND-MEDIATED BLOOD-BRAIN BARRIER OPENING AND PANOBINOSTAT FOR DIFFUSE INTRINSIC PONTINE GLIOMA TREATMENT." Neuro-Oncology 23, Supplement_1 (2021): i52. http://dx.doi.org/10.1093/neuonc/noab090.209.

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Abstract Diffuse intrinsic pontine glioma (DIPG) is the lethal high-grade brain tumor in children with no effective treatment options to date. Despite excessive clinical trials, the prognosis remains poor, with a median overall survival (mOS) of less than 1 year. Genomic studies of DIPG tissue have identified highly recurrent mutations in genes encoding histone H3 resulting in the substitution of lysine to methionine at position 27 (K27M), which is found in approximately 80% of DIPG. Recent drug screening studies identified the histone deacetylase (HDAC) inhibitors panobinostat as a highly eff

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Elliott, Jacob C., Grace M. Wood, and Julianna C. Simon. "Real-time assessment of focused ultrasound-induced bioeffects in elastic tissues." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A50—A51. http://dx.doi.org/10.1121/10.0026763.

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Highly elastic tissues have proven resistant to fractionation via focused ultrasound (fUS); however, our previous work in rat tendon has demonstrated a small window of parameters conducive to mild mechanical disruption. For therapeutic applications, there is a need to assess the extent of fUS-induced mechanical bioeffects in real time in order to avoid over- or under-treatment. Here, elastic collagen hydrogels (TeloCol®-10), as well as healthy and collagenase-soaked ex vivo bovine tendons, were exposed to fUS at 1.1–3.68 MHz (p + ≤ 127 MPa, p− ≤ 35 MPa) using 10-ms pulses repeated at 1 Hz. Cav

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Johnson, Sara L., Henrik Odeen, Allison Payne, and Harry Vine. "An MR-compatible fiber-optic probe for measuring focused ultrasound-induced temperature rises without viscous heating artifacts." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A323. http://dx.doi.org/10.1121/10.0027673.

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Focused ultrasound (FUS) beam interactions with thermocouples and fiber optic (FO) probes cause a “viscous heating artifact” (VHA), which prevent accurate temperature measurements during acoustic sonication. This work demonstrates a novel fiber-optic temperature probe which is insensitive to VHA, validated in an MR-guided FUS treatment setting. The FO probe (OSENSA Innovations; PRB-140, 0.14 mm diameter) was inserted with an 18G catheter into a tissue-mimicking gelatin phantom. The FO probe tip was located with high-resolution MR images (0.25 × 0.25 × 0.5 mm3) for targeting with FUS. Continuou

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Dillon, Patrick Michael, Bethany J. Horton, Timothy Bullock, Christiana Brenin, and David R. Brenin. "Focused ultrasound therapy combined with pembrolizumab in metastatic breast cancer." Journal of Clinical Oncology 36, no. 5_suppl (2018): TPS19. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.tps19.

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TPS19 Background: Focused ultrasound (FUS) is an ablative therapy which can heat tumors rapidly to cell damaging temperatures and simultaneously perturb the microenvironment, the microvasculature, and the lymphatics. At typical energy levels, FUS can induce controlled apoptotic cell death rather than liquefactive necrosis. FUS does not involve radiation. FUS is a partially ablative therapy using high energy ultrasound waves to induce heat shock proteins, cytokine release and cellular mediated mechanisms resulting in T cell activation and recognition of tumor antigens. FUS has been demonstrated

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Teplov, V. M., N. D. Arkhangelskiy, E. A. Tsebrovskaya, and S. F. Bagnenko. "Benefits of using imaging techniques for triage in inpatient emergency department." Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations, no. 1 (June 8, 2025): 54–60. https://doi.org/10.25016/2541-7487-2025-0-1-54-60.

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Relevance. Imaging techniques allow to optimize inpatient medical triage in emergency medical care and enhance treatment outcomes. Today, such techniques as automated ECG interpretation (AIECG) and focused ultrasound (FUS) are highly relevant. However, the optimization efficiency in Russia is yet pending a thorough study.Objective. The objective is to assess the efficiency of a three-level medical triage system, evaluating the contribution AIECG and FUS examination.Methods. The study is a retrospective analysis of 1,000 patient cases of emergency medical care, provided by the inpatient emergen

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Cressey, Paul, Chris Payne, Amelia Claxton, et al. "Abstract 2524: Lipid-based nanoparticles for the theranostic treatment of brain tumors using focused ultrasound." Cancer Research 85, no. 8_Supplement_1 (2025): 2524. https://doi.org/10.1158/1538-7445.am2025-2524.

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Abstract Glioblastoma is an extremely aggressive brain tumor and currently has limited effective treatment options, with a median survival of 14 months. This low survival is partially attributed to the blood-brain barrier (BBB), especially in early-stage glioblastoma. An emerging clinically approved technology to non-invasively and transiently open the BBB is focused ultrasound (FUS) in combination with microbubble cavitation. In this study, we formulated a dual-imageable drug-loaded lipid-based nanoparticle (ActNano) and tested their efficacy against U87-MG in vitro and in vivo (subcutaneous)

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Wang, Shutao, Cheng-Chia Wu, Hairong Zhang, et al. "Focused ultrasound induced-blood–brain barrier opening in mouse brain receiving radiosurgery dose of radiation enhances local delivery of systemic therapy." British Journal of Radiology 93, no. 1109 (2020): 20190214. http://dx.doi.org/10.1259/bjr.20190214.

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Objective: Investigate the temporal effects of focused ultrasound (FUS)-induced blood–brain barrier (BBB) opening in post-radiotherapy mouse brains. Methods and materials: C57B6 mice without tumors were used to simulate the scenario after gross total resection (GTR) of brain tumor. Radiation dose of 6 Gy x 5 was delivered to one-hemisphere of the mouse brain. FUS-induced BBB-opening was delivered to the irradiated and non-irradiated brain and was confirmed with MRI. Dynamic MRI was performed to evaluate blood vessel permeability. Two time points were selected: acute (2 days after radiation) an

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Rytkönen, Jussi, Kimmo Lehtimäki, Taina-Kaisa Stenius, Riikka Immonen, Ari Suhonen, and Artem Shatillo. "Abstract LB155: In vivo imaging of vascular pathology in mouse orthotopic glioma model using functional ultrasound." Cancer Research 83, no. 8_Supplement (2023): LB155. http://dx.doi.org/10.1158/1538-7445.am2023-lb155.

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Abstract Neovascularization together with aberrant vasculature is a hallmark of glioblastomas. Understanding tumor vasculature can have a pivotal role in planning therapeutics approaches. The objective of this study was to investigate morphological, vasculature and blood flow changes induced by aggressive tumor growth, using in vivo imaging - magnetic resonance imaging (MRI) and functional ultrasound (fUS) imaging in a mouse model of orthotopic glioma. Female NMRI nude mice were xenografted orthotopically with U-87 MG, a human glioblastoma, cells (5 × 104) at the age of 8 weeks. Four weeks aft

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Yang, Jack B., Lauren Powlovich, David Moore, et al. "Transcutaneous Ablation of Lung Tissue in a Porcine Model Using Magnetic-Resonance-Guided Focused Ultrasound (MRgFUS)." Tomography 10, no. 4 (2024): 533–42. http://dx.doi.org/10.3390/tomography10040042.

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Focused ultrasound (FUS) is a minimally invasive treatment that utilizes high-energy ultrasound waves to thermally ablate tissue. Magnetic resonance imaging (MRI) guidance may be combined with FUS (MRgFUS) to increase its accuracy and has been proposed for lung tumor ablation/debulking. However, the lungs are predominantly filled with air, which attenuates the strength of the FUS beam. This investigation aimed to test the feasibility of a new approach using an intentional lung collapse to reduce the amount of air inside the lung and a controlled hydrothorax to create an acoustic window for tra

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Sheybani, Natasha Diba, Alexandra R. Witter, Timothy N. Bullock, and Richard J. Price. "MR image-guided focused ultrasound immune modulation for glioma therapy." Journal of Immunology 200, no. 1_Supplement (2018): 178.26. http://dx.doi.org/10.4049/jimmunol.200.supp.178.26.

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Abstract Glioblastoma (GB) is the most common and malignant brain tumor. Despite standard treatment with surgery, radiation and chemotherapy, its diffuse nature and proclivity for recurrence renders it largely intractable. Immunotherapy (ITx) approaches (e.g. anti-PD1) may hold promise for treating GB; however, the blood-brain (BBB) and blood-tumor (BTB) barriers hinder delivery of systemically administered ITx drugs. A potential approach to enhancing ITx delivery is MRI-guided focused ultrasound (FUS), a non-invasive technique that, when combined with concomitant systemic injection of microbu

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