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Relevant bibliographies by topics / Functions and Indoles

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Journal articles

Academic literature on the topic 'Functions and Indoles'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "Functions and Indoles"

1

Moldvai, István, Eszter Gács-Baitz, and Csaba Szántay. "Chemistry of indoles carrying basic functions. I. Transformation of hydroxyindolones into indoles." Recueil des Travaux Chimiques des Pays-Bas 110, no. 11 (2010): 437–40. http://dx.doi.org/10.1002/recl.19911101102.

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2

MOLDVAI, I., E. GACS-BAITZ, and C. SZANTAY. "ChemInform Abstract: Chemistry of Indoles Carrying Basic Functions. Part 1. Transformation of Hydroxyindolones into Indoles." ChemInform 23, no. 14 (2010): no. http://dx.doi.org/10.1002/chin.199214194.

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3

Chang, Chieh-Yu, Yu-Huan Lin, and Yen-Ku Wu. "Palladium-catalyzed N1-selective allylation of indoles with allylic alcohols promoted by titanium tetraisopropoxide." Chemical Communications 55, no. 8 (2019): 1116–19. http://dx.doi.org/10.1039/c8cc09817d.

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4

Zhai, Yizhan, Xue Zhang, and Shengming Ma. "Stereoselective rhodium-catalyzed 2-C–H 1,3-dienylation of indoles: dual functions of the directing group." Chemical Science 12, no. 34 (2021): 11330–37. http://dx.doi.org/10.1039/d1sc02167b.

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A rhodium-catalyzed intermolecular highly stereoselective 1,3-dienylation at the 2-position of indoles with non-terminal allenyl carbonates has been developed by using 2-pyrimidinyl or pyridinyl as the directing group.

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5

Sz�tay, Csaba, Istv� Moldval, Csaba Sz�tay Jr., and Csaba Sz�tay. "Chemistry of Indoles Carrying Basic Functions. Part II. Synthesis of 4-Substituted Cyclohept[c.d]indoles. A New Entry into the Ring System." HETEROCYCLES 34, no. 2 (1992): 219. http://dx.doi.org/10.3987/com-91-5803.

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6

Vadaq, Nadira, Yue Zhang, Elise Meeder, et al. "Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV." International Journal of Tryptophan Research 15 (January 2022): 117864692211268. http://dx.doi.org/10.1177/11786469221126888.

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Background: People living with HIV (PLHIV) exhibit dysregulation of tryptophan metabolism. Altered gut microbiome composition in PLHIV might be involved. Mechanistic consequences within the 3 major tryptophan metabolism pathways (serotonin, kynurenine, and indoles), and functional consequences for platelet, immune and behavioral functions are unknown. We investigated plasma tryptophan metabolites, gut microbiome composition, and their association with platelet function, inflammation, and psychiatric symptoms. Methods: This study included 211 PLHIV on long-term antiretroviral treatment (ART). Plasma tryptophan pathway metabolites were measured using time-of-flight mass spectrometry. Bacterial composition was profiled using metagenomic sequencing. Platelet reactivity and serotonin levels were quantified by flowcytometry and ELISA, respectively. Circulating inflammatory markers were determined using ELISA. Symptoms of depression and impulsivity were measured by DASS-42 and BIS-11 self-report questionnaires, respectively. Results: Plasma serotonin and indole metabolites were associated with gut bacterial composition. Notably, species enriched in PLHIV were associated with 3-methyldioxyindole. Platelet serotonin concentrations were elevated in PLHIV, without effects on platelet reactivity. Plasma serotonin and indole metabolites were positively associated with plasma IL-10 and TNF-α concentrations. Finally, higher tryptophan, serotonin, and indole metabolites were associated with lower depression and anxiety, whereas higher kynurenine metabolites were associated with increased impulsivity. Conclusion: Our results suggest that gut bacterial composition and dysbiosis in PLHIV on ART contribute to tryptophan metabolism, which may have clinical consequences for immune function and behavior.

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7

MOLDVAI, I., C. JUN SZANTAY, and C. SZANTAY. "ChemInform Abstract: Chemistry of Indoles Carrying Basic Functions. Part 2. Synthesis of 4- Substituted Cyclohept(c,d)indoles. A New Entry into the Ring System." ChemInform 23, no. 27 (2010): no. http://dx.doi.org/10.1002/chin.199227169.

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8

Bock, Karl Walter. "Human and rodent aryl hydrocarbon receptor (AHR): from mediator of dioxin toxicity to physiologic AHR functions and therapeutic options." Biological Chemistry 398, no. 4 (2017): 455–64. http://dx.doi.org/10.1515/hsz-2016-0303.

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Abstract Metabolism of aryl hydrocarbons and toxicity of dioxins led to the discovery of the aryl hydrocarbon receptor (AHR). Tremendous advances have been made on multiplicity of AHR signaling and identification of endogenous ligands including the tryptophan metabolites FICZ and kynurenine. However, human AHR functions are still poorly understood due to marked species differences as well as cell-type- and cell context-dependent AHR functions. Observations in dioxin-poisoned individuals may provide hints to physiologic AHR functions in humans. Based on these observations three human AHR functions are discussed: (1) Chemical defence and homeostasis of endobiotics. The AHR variant Val381 in modern humans leads to reduced AHR affinity to aryl hydrocarbons in comparison with Neanderthals and primates expressing the Ala381 variant while affinity to indoles remains unimpaired. (2) Homeostasis of stem/progenitor cells. Dioxins dysregulate homeostasis in sebocyte stem cells. (3) Modulation of immunity. In addition to microbial defence, AHR may be involved in a ‘disease tolerance defence pathway’. Further characterization of physiologic AHR functions may lead to therapeutic options.

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9

Duvauchelle, Valentin, David Bénimélis, Patrick Meffre та Zohra Benfodda. "Catalyst-Free Site Selective Hydroxyalkylation of 5-Phenylthiophen-2-amine with α-Trifluoromethyl Ketones through Electrophilic Aromatic Substitution". Molecules 27, № 3 (2022): 925. http://dx.doi.org/10.3390/molecules27030925.

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An original and effective approach for achieving trifluoromethyl hydroxyalkylation of 5-phenylthiophen-2-amine using α-trifluoromethyl ketones is described. In the last few years, reaction of Friedel-Crafts had been widely used to realize hydroxyalkylation on heterocycles such as indoles or thiophenes by means of Lewis acid as catalyst. Additionally, amine functions are rarely free when carbonyl reagents are used because of their tendency to form imines. This is the first time that a site-selective electrophilic aromatic substitution on C3 atom of an unprotected 5-phenylthiophen-2-amine moiety is reported. The liberty to allow reaction in neutral conditions between free amine is valuable in a synthesis pathway. The reaction proceeds smoothly using an atom-economical metal-and catalyst-free methodology in good to excellent yields. A mechanism similar to an electrophilic aromatic substitution has been proposed.

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10

Bershtein, L. M. "E. J. Pavlik, ed. Estrogens, progestins and their antagonists. - Vol. 2. Functions and mechanisms of action. - Boston, Basel, Berlin: Bikhauser, 1996 .-- 632 p." Problems of Endocrinology 44, no. 2 (2019): 53–54. http://dx.doi.org/10.14341/probl199844253-54.

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The book under review is part of a lengthy and interesting series for specialists, published by the Birkhauser Publishing House and having the common title Hormones in Normal and Pathological Conditions. The first volume of the book, a review of which is published in Issue 3 of the journal “Oncology Issues” for 1997, deals mainly with the degree of oncological risk of estrogen replacement therapy in menopause, about the not always unambiguous anticarcinogenic properties of phytoestrogens and food indoles, and about modern approaches to hormone therapy for prostate cancer, etc., i.e., mainly about the problems of oncological endocrinology. The 2nd volume of this publication, as its editor E. Pavlik writes in the introduction to the book, is devoted to the physiological and molecular mechanisms of action of estrogens, progestins and their antagonists, and is primarily focused on the discussion of the effect of various and often even opposite effects these compounds in different cells and tissues. A highly qualified team of authors, assembled by the editor, was able to ensure the implementation of this difficult and responsible task.

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