Relevant bibliographies by topics / Functionalized gold nanoparticle

Academic literature on the topic 'Functionalized gold nanoparticle'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Functionalized gold nanoparticle"

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Abad, José M., Sara Puertas, Daniel Pérez, and Christian Sánchez-Espinel. "Design and Development of Antibody Functionalized Gold Nanoparticles for Biomedical Applications." Journal of Nanoscience and Nanotechnology 21, no. 5 (May 1, 2021): 2834–40. http://dx.doi.org/10.1166/jnn.2021.19057.

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Antibody-functionalized gold nanoparticle constitutes a powerful interface biosystem for biomedical applications where the properties of gold nanoparticles and the specificity of antibody–antigen interactions are combined. This study provides insight into the key factors for the development of antibody functionalized gold nanoparticles focusing on the immobilization of the antibody. Here, we address an oriented antibody immobilization procedure on gold nanoparticles. It comprises chelatemodified gold nanoparticles that are designed for oriented immobilization of IgG antibodies (end on spatial orientation) through the metal-chelation to histidine-rich metal binding site in the heavy chain (Fc) of the antibody.
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Thaxton, C. Shad, Nathaniel L. Rosi, and Chad A. Mirkin. "Optically and Chemically Encoded Nanoparticle Materials for DNA and Protein Detection." MRS Bulletin 30, no. 5 (May 2005): 376–80. http://dx.doi.org/10.1557/mrs2005.101.

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AbstractNanoscale materials are beginning to have an impact in the field of molecular diagnostics. In particular, gold nanoparticles surface-functionalized with DNA have garnered much recent interest. Due to the unusual optical and catalytic properties of gold nanoparticle labels, several distinct advantages for assay readout have been realized. This review focuses on the progress made in our group over the past seven years in the development of particle surface chemistry and ultrasensitive protein and nucleic acid assays based upon DNA-functionalized gold nanoparticles. For DNA targets, experiments demonstrate that assays based upon gold nanoparticle labels have enhanced target specificity and in certain cases the sensitivity of polymerase chain reaction (PCR), without the need for target amplification. For protein targets, similar experiments demonstrate that assays based upon gold nanoparticles are up to one million times more sensitive than conventional protein detection methods. Recent data using human samples demonstrate the utility of such assays.
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Thomas, K. George, Binil Itty Ipe, and P. K. Sudeep. "Photochemistry of chromophore-functionalized gold nanoparticles." Pure and Applied Chemistry 74, no. 9 (January 1, 2002): 1731–38. http://dx.doi.org/10.1351/pac200274091731.

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It is generally believed that metal nanoparticles strongly quench the singlet-excited states of chromophores when attached to nanoparticle surfaces, through an energy-transfer mechanism, which limits their application in optoelectronic devices and photonic materials. Recent studies of fluorophore-linked metal nanoparticles reveal that there is a dramatic suppression in the quenching of the singlet-excited state of these molecules and they possess unusual photophysical properties. A summary of our work on the photophysical and excited-state properties of chromophore-functionalized gold nanoparticles is presented in this article. Pyrene-capped gold nanoparticles showed normal fluorescence in nonpolar solvents and an intermolecular excimer formation at higher loadings. The quenching of the emission, observed in pyrene-labeled gold nanoparticles in polar solvents, is attributed to the formation of pyrene radical cation through a photoinduced electron-transfer process. We have also functionalized gold nanoparticles using a thiol derivative of fullerene. The quenching of fluorescence and decreased yields of triplet-excited state, observed in these systems, are attributed to an energy-transfer process.
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Zhang, Liangmin. "Optical Conduction Resonance in Self-Assembled Metal Nanoparticle Array-Dielectric Thin Films." Journal of Nanomaterials 2018 (December 10, 2018): 1–9. http://dx.doi.org/10.1155/2018/8540805.

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Optical conduction resonance- (OCR-) enhanced third-order optical nonlinearity of two dimensional (2D) periodic gold nanoparticle array-dielectric thin films has been investigated. The third-order optical susceptibility of periodic gold nanoparticle array embedded in silica thin film shows ~104 enhancement comparing to gold nanoparticle colloids. The 2D gold nanoparticle arrays were synthesized by using the electrostatic self-assembly (ESA) technique. During the fabrication process, the positively or negatively functionalized gold nanoparticles are automatically self-aligned to establish a 2D array with a very small interparticle spacing due to the polymer shell on the metal particles. Then, a monolayer of silica can be coated on the top of the 2D metal nanoparticle array. This type of 2D gold nanoparticle array-dielectric thin films has high volume fraction of gold nanoparticles. According to the extended Maxwell-Garnett theory, this kind of films can exhibit OCR. The OCR frequency can be tuned from visible to mid-infrared by controlling the gold nanoparticle volume fraction. During OCR, the real part of the composite dielectric constant is zero to make the induced electromagnetic waves in gold nanoparticles to couple effectively within the film. The open-aperture z-scan technique is used to measure the nonlinear optical properties of the ESA films.
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García-Astrain, C., I. Ahmed, D. Kendziora, O. Guaresti, A. Eceiza, L. Fruk, M. A. Corcuera, and N. Gabilondo. "Effect of maleimide-functionalized gold nanoparticles on hybrid biohydrogels properties." RSC Advances 5, no. 62 (2015): 50268–77. http://dx.doi.org/10.1039/c5ra06806a.

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Dixon, D., B. J. Meenan, and J. Manson. "PEG Functionalized Gold Nanoparticle Loaded PLGA Films for Drug Delivery." Journal of Nano Research 27 (March 2014): 83–94. http://dx.doi.org/10.4028/www.scientific.net/jnanor.27.83.

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A novel composite of poly (ethylene glycol) (PEG) functionalized gold nanoparticles (AuNP-PEG) dispersed within Poly (lactic-go-glycolic) (PLGA) films, were prepared to demonstrate the concept of a combined targeted and sustained implant material. This technology offers the promise of improved therapies for difficult to treat tumors such as Gliomas. Gold nanoparticles (AuNPs) synthesized via a modified Turkevich method, were functionalized with thiol terminated polyethylene glycol (PEG), washed using centrifugation, dried, re-suspended in a solution of PLGA in dichloromethane and finally vacuum dried to produce the solvent cast films. The degradation and nanoparticle release profile of these films were studied by immersion in PBS media at 37 °C over periods of up-to 58 days. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was conducted. The release of the AuNPs-PEG nanoparticles during degradation was studied using inductively coupled plasma mass spectroscopy (ICP-MS). It was observed that the AuNP-PEG nanoparticles were individually dispersed within the PLGA and that their addition extended the degradation time of the PLGA film, but did not appear to alter the nature of degradation. The nanoparticle release from the composite films displayed an approximately zero-order release profile.
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Park, So-Jung, T. Andrew Taton, and Chad A. Mirkin. "Array-Based Electrical Detection of DNA with Nanoparticle Probes." Science 295, no. 5559 (February 22, 2002): 1503–6. http://dx.doi.org/10.1126/science.1067003.

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A DNA array detection method is reported in which the binding of oligonucleotides functionalized with gold nanoparticles leads to conductivity changes associated with target-probe binding events. The binding events localize gold nanoparticles in an electrode gap; silver deposition facilitated by these nanoparticles bridges the gap and leads to readily measurable conductivity changes. An unusual salt concentration–dependent hybridization behavior associated with these nanoparticle probes was exploited to achieve selectivity without a thermal-stringency wash. Using this method, we have detected target DNA at concentrations as low as 500 femtomolar with a point mutation selectivity factor of ∼ 100,000:1.
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Manivannan, Shanmugam, and Ramasamy Ramaraj. "Polymer-embedded gold and gold/silver nanoparticle-modified electrodes and their applications in catalysis and sensors." Pure and Applied Chemistry 83, no. 11 (July 11, 2011): 2041–53. http://dx.doi.org/10.1351/pac-con-11-03-04.

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Metal nanoparticles encapsulated by silicate sol-gel matrix find numerous applications particularly in electrocatalysis and sensors. In our previous reports, we have reported the mono- and bi-metal gold, silver, and core/shell gold/silver nanoparticles embedded in functionalized silicate sol-gel matrices. Modified electrodes were fabricated using mono- and bi-metallic gold, silver, and core/shell gold/silver nanoparticles embedded in silicate sol-gel, and they were used for the electrocatalysis and sensing of H2O2 and simultaneous detection of hydrazine, sulfite, and nitrite. We have prepared the gold nanoparticles encapsulated by amine-functionalized silicate sol-gel matrix in a single step without using any external reducing agents. The gold nanoparticles were also synthesized by using amine-functionalized silane monomer in the presence of β-cyclodextrin (β-CD), resulting in metal/polymer core/shell nanostructures. This nanocomposite material showed a synergistic stabilizing effect when compared to either silicate sol-gel matrix or β-CD alone as stabilizer. The synthesized gold nanoparticles were characterized using UV–vis spectroscopy and high-resolution transmission electron microscopy. Modified electrodes were prepared by using the gold nanoparticles embedded in silicate sol-gel matrix, and their electrochemical characteristics were studied.
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WANG, CHIH-KUANG, SZU-HSIEN CHEN, WAN-YUN LI, CHERN-HSIUNG LAI, and WEN-CHENG CHEN. "BIOACTIVE GLASS SHELL GROWTH OF A Si–Na–Ca–P LAYER ON GOLD NANOPARTICLES FUNCTIONALIZED WITH MERCAPTOPROPYLTRIMETHYLOXYSILANE–SILICATE–TETRAETHYLOTHOSILICATE." Surface Review and Letters 16, no. 01 (February 2009): 37–42. http://dx.doi.org/10.1142/s0218625x09012263.

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Calcium phosphate and silicate-modified gold surfaces have potential applications in orthopedic and dental reconstruction, especially when combined with bone cement or dental resins. The aim of this study was to evaluate the formation of a Si – Na – Ca – P glass system nanoshell on functionalized gold nanoparticles. Stable gold nanoparticle suspensions were prepared by controlled reduction of HAuCl 4 using the sodium citrate method to obtain a nanogold-mercaptopropyltrimethyloxysilane (MPTS)–silicate–tetraethylothosilicate (TEOS)-capped particle solution. The nanoshells were formed when directly reacted with a 10-4 M calcium phosphate ion solution. The median nanoparticle diameter was observed to be 15 nm. The MPTS–silicate–TEOS–functionalized nanoshell more effectively formed a glass shell as compared with a nonsilicate nanoshell. The changes in the surface morphology and composition were observed by a scanning transmission electron microscope equipped with energy-dispersive X-ray spectroscopy. As seen using EDS, the nanoshell was in a glass phase with CaO -poor layers.
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Yang, Wenrong, J. Justin Gooding, Zhicong He, Qiong Li, and Guonan Chen. "Fast Colorimetric Detection of Copper Ions Using L-Cysteine Functionalized Gold Nanoparticles." Journal of Nanoscience and Nanotechnology 7, no. 2 (February 1, 2007): 712–16. http://dx.doi.org/10.1166/jnn.2007.116.

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This communication reports an efficient visual detection method of Cu2+ by L-cysteine functionalized gold nanoparticles in aqueous solution. Upon exposure to Cu2+, the gold nanoparticle solution changed from red to blue, in response to surface plasmon absorption of dispersed and aggregated nanoparticles. This colorimetric sensor allows a rapid quantitative assay of Cu2+ down to the concentration range of 10−5 M. Recognition of Cu2+ and formation of the aggregates are proposed to occur via a 2 : 1 sandwich complex between L-cysteine and Cu2+.
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Dissertations / Theses on the topic "Functionalized gold nanoparticle"

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D'ALICARNASSO, MARCO. "SURFACE FUNCTIONALIZED GOLD NANOPARTICLES AS ATTACHMENT INHIBITORS FOR HEPARAN SULFATE-BINDING VIRUSES." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/366392.

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Infectious diseases account for one fifth of global mortality. Although many efforts have been made to prevent and treat specific viral diseases (e.g. hepatitis B, AIDS) with vaccines and drugs, we still lack effective and biocompatible broad-spectrum antiviral agents, especially against re-emerging (e.g. Dengue virus) and newly emerging viruses (e.g. Ebola virus). Current advances in nanotechnology opened new frontiers in developing novel antivirals that can interact and inactivate a large number of viral pathogens. Nanoparticles (NPs) – particles in the size range 1-100 nm – can be finely engineered on their surface to interfere with key events of infections shared by many viruses, above all the attachment to the host cell. The aim of the present work is to assess the role of gold nanoparticles (Au- NPs) capped with sulfonate molecules as potential inhibitors toward human viruses binding sulfated polysaccharides on the cell membrane. Results showed that sulfonated NPs have powerful antiviral as well as virucidal activity. Their applications may lead to substantial improvements in virus-spread control not only as novel wide-spectrum therapeutic agents but most importantly as novel active materials to be employed in emergency situations, for example in personal protective equipment, waste management, virus containment.
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Cheng, Xiang. "Gold-Nanoparticle Cored Carbazole Functionalized Star-like Copolymer Hybrid Nanomaterial with Tunable Properties." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522803372777943.

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FATEHBASHARZAD, PARISA. "Functionalized Concave Cube Gold Nanoparticles as Dual probe for Magnetic Resonance Imaging and Surface Enhanced Raman Scattering." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/273768.

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An innovative class of MRI CAs is represented by Gd-loaded gold nanoparticles. Differently from other nano-sized systems, the size, shape and chemical functionalization appear to affect the observed relaxation enhancement of water protons in their suspensions. The herein reported results shed more light on the determinants of the relaxation enhancement brought by Gd-loaded concave cube gold nanoparticles. It has been found that the role of the concave surface of these nanoparticles in the relaxivity is remarkable and it provides high contribution of second sphere water molecules. The specific shape of concave cube nanoparticles increases the relaxivity from 20.9 mM-1S-1 for spherical nanoparticles to 36.3 mM-1S-1. On the other hand, our studies prove that this special shape gold nanoparticles show high efficiency as a SERS probe. In the single-particle surface-enhanced Raman spectroscopy, the use of tunable plasmonic nanoparticles, having tipped surface structures, as being substrates revealed a highly feasible and promising approach to optimize SERS-based imaging and sensing applications. The concave cubic morphology has shown a remarkable plasmonic response, representing high sensitivity to the concavity degree. hence they can provide strong Raman signal which can be use in Raman imaging. Magnetic resonance and optical imaging are complementary techniques. By applying same nanoparticles as a contrast agent for both methods simultaniusly, screening total body with very clear identification become possible. This progress in imaging technologies associated with the advance of nanotechnology makes feasible the cancer detection and localization in its early stage.
An innovative class of MRI CAs is represented by Gd-loaded gold nanoparticles. Differently from other nano-sized systems, the size, shape and chemical functionalization appear to affect the observed relaxation enhancement of water protons in their suspensions. The herein reported results shed more light on the determinants of the relaxation enhancement brought by Gd-loaded concave cube gold nanoparticles. It has been found that the role of the concave surface of these nanoparticles in the relaxivity is remarkable and it provides high contribution of second sphere water molecules. The specific shape of concave cube nanoparticles increases the relaxivity from 20.9 mM-1S-1 for spherical nanoparticles to 36.3 mM-1S-1. On the other hand, our studies prove that this special shape gold nanoparticles show high efficiency as a SERS probe. In the single-particle surface-enhanced Raman spectroscopy, the use of tunable plasmonic nanoparticles, having tipped surface structures, as being substrates revealed a highly feasible and promising approach to optimize SERS-based imaging and sensing applications. The concave cubic morphology has shown a remarkable plasmonic response, representing high sensitivity to the concavity degree. hence they can provide strong Raman signal which can be use in Raman imaging. Magnetic resonance and optical imaging are complementary techniques. By applying same nanoparticles as a contrast agent for both methods simultaniusly, screening total body with very clear identification become possible. This progress in imaging technologies associated with the advance of nanotechnology makes feasible the cancer detection and localization in its early stage.
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Selegård, Robert. "Polypeptide functionalized gold nanoparticles for bioanalytical applications." Doctoral thesis, Linköpings universitet, Molekylär fysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106719.

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Detection strategies that allow for simple, rapid, cost efficient and sensitive monitoring of proteins and their interactions with biomolecules are of great importance in drug development and diagnostics. This thesis describes the development of bioanalytical applications based on the tunable self-assembly of gold nanoparticles functionalized with a de novo designed polypeptide. Strategies for protein affinity sensing and for detection of several fundamentally important biological processes have been investigated, including Zn2+-mediated coordination between polypeptides and low molecular weight chelants and protease and phosphatase activity. A Zn2+ responsive synthetic polypeptide designed to fold into a helix-loop-helix motif and dimerize into a four-helix bundle has been used to control the stability and self-assembly of gold nanoparticles. This polypeptide has a high negative net charge at neutral pH as a consequence of its many glutamic acid residues, efficiently preventing folding and dimerization due to charge repulsion. Zn2+ coordination provides a means to trigger folding and dimerization at neutral pH. The polypeptide can be readily attached to gold nanoparticles via a cysteine residue in the loop region, retaining its folding properties and responsiveness to Zn2+. The polypeptide functionalized gold nanoparticles display excellent colloidal stability but aggregate reversibly after addition of millimolar concentrations of Zn2+. Aggregates are dense with a defined interparticle distance corresponding to the size of the four-helix bundle, resulting in a distinct red shift of the localized surface plasmon resonance band. Three completely different strategies for colorimetric biosensing have been developed, all being based on the same responsive hybrid nanomaterial. In the first strategy a synthetic receptor was co-immobilized on the gold nanoparticles together with the Zn2+ responsive polypeptide. Protein analyte binding to the receptor could be detected as this interaction sterically prevented aggregation induced by Zn2+. In the second strategy the reduction in colloidal stability caused by specific proteolytic cleavage of the immobilized polypeptide was exploited to monitor the enzymatic activity. The third strategy utilized the sensitivity of the system to small variations in Zn2+ concentration. The presence of low molecular weight chelants was found to influence the mode of aggregation, both by sequestering Zn2+ and through the formation of ternary complexes involving the polypeptides, which prevented dimerization and thus aggregation. This approach was further developed into a generic concept for phosphatase detection exploiting the different affinity of enzyme substrates and reaction products for Zn2+. The flexibility of the different detection schemes enables detection of a large number of analytes by exploiting the tunable stability of the nanoparticles and the possibilities to effectively decouple the recognition event and the nanoparticle stability modulation.
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Padilla, Barriento Marc. "Photoactive materials based on cyclodextrin-functionalized gold nanoparticles." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/459116.

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L’objectiu d’aquesta tesi és la preparació, la caracterització I l’aplicació de nous materials fotoactius basats en nanopartícules d’or (Au NPs). Degut a les seves interessants propietats òptiques, les potencials aplicacions d’ aquests nanomaterials estant sent intensament explorades en diversos camps d’estudi com la ciencia de materials, la nanomedicina I la nanotecnologia. En moltes d’aquestes aplicacions es crucial la interaccio del nanomaterial amb d’altres molècules, i per això es necessari induir l’apropament entre aquestes estructures i d’altres especies químiques. En aquesta tesi, s’ha explorat la utilització de la química supramolecular com a estratègia per afavorir aquesta aproximació i intentar millorar les aplicacions d’aquestes nanoestructures. Per dur a terme aquesta estrategia, s’han preparat derivats tiolats de ciclodextrines (CD) que s’han incorporat a la superfície de les Au NPs per tal de: i) millorar l’activitat fotocatalítica de les Au NPs en front de reaccions químiques ii) induir l’agregació i desagregació de Au NPs de forma controlada amb llum. En el primer cas, es va poder fotocatalitzar la reacció unimolecular d’isomerització de Z-estilbens amb Au NPs funcionalitzades amb B-CD de forma més eficient que amb Au NPs no funcionalitzades, però quan es van intentar aplicar aquests resultats a processos bimoleculars, Au NPs funcionalitzades amb y-CD no van proporcionar cap tipus de conversió en la reacció de dimerització d’antracens assajada. Pel que fa als estudis d’agregació, els nostres resultats posen de relleu la importància de tenir en compte les interaccions inespecífiques quan s’intenta desenvolupar nous sistemes a través d’associació supramolecular del tipus amfitrió-hoste. En conclusió, en la present tesi doctoral, s’ha demostrat el gran potencial que té la combinació de nanoestructures plasmòniques amb la química supramolecular per al desenvolupament de nous materials fotoactius amb propietats millorades, contribuint així al creixent coneixement en el camp de la nanociència.
The present thesis aimed at the preparation, characterization and application of new photoactive materials based on gold nanoparticles (Au NPs). Due to their interesting optical properties, the potential applications of these nanomaterials are being intensively explored in diverse fields of research like medicine, meterials science and technology. In many of these applications it is crucial the interaction between the nanomaterial and other molecules, and therefore it is necessary to induce the approximation between the nanomaterial and other chemical species. In this thesis we explored the utilization of supramolecular chemistry as an strategy to favor such approximation and try to enhance the potential applications of such nanostructures. For that, proper thiolated derivatives of the cyclodextrin (CD) family of supramolecular hosts have been prepared and subsequently incorporated onto the surface of Au NPs to: i) enhance the photocatalytic activity of Au NPs towards chemical reactions, ii) to induce the aggregation and disaggregation of Au NPs controlled with light. In the former case, B-CD-functionalized Au NPs were able to photocatalyze the isomerization of Z-stilbenes more efficiently than non-functionalized particles, but when trying to expand these results to bimolecular processes, y-CD-functionalized particles did not provide any conversion towards the selected reaction. Regarding the assembly studies, our results highlighted the importance of considering unspecific interactions when trying to develop new systems via specific host-guest association. In conclusion, in the present thesis we have demonstrated the great potential of combining plasmonic nanostructures with supramolecular chemistry to develop new photoactive materials with improved properties, contributing with our work to the increasing knowledge in the expanding field of the nanosicience.
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Kumar, Dhiraj. "Co-Functionalised Gold Nanoparticles for Drug Delivery Applications." Thesis, Ulster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649271.

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Warsi, Muhammad F. "Lanthanide functionalised gold nanoparticles as MRI contrast agents." Thesis, University of York, 2010. http://etheses.whiterose.ac.uk/1105/.

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The aim of this Ph. D. project was to synthesize and characterise nanoparticle-based MRI contrast agents. In the first instance, the DTPA (diethylenetriaminepentaacetic acid) based ligand was designed, synthesized and characterised. This ligand was utilised for stabilisation of gold nanoparticles. The gold nanoparticles protected by DTPA based ligand were characterised using UV-Vis, NMR spectroscopies, TGA and TEM. The nanoparticles were then loaded with gadolinium. The relaxivity of gadolinium loaded gold nanoparticles were studied using inversion recovery method and compared with commercially available MRI contrast agents (i.e. Gd-DTPA). The Gd-loaded AuNPs showed only a moderate increase in their relaxivity as compared to the Gd-DTPA complex. The factors limiting the relaxivity of Gd-loaded AuNPs were explored using EPR spectroscopy. For EPR measurements, Gd3+ was replaced with vanadyl (VO2+) which gives EPR spectra sensitive to the rate of molecular tumbling on nanosecond time scale. The EPR measurements of VO2+-loaded AuNPs showed that the nanoparticle attached metal ion retains high molecular mobility. This is likely responsible for only a moderate increase in relaxivity. We next explored different strategies for increasing the relaxivity of gold nanoparticles based MRI contrast agents. In the first strategy, in order to enhance ligand packing at AuNPs surface, the size of the AuNPs was increased from ~2.0 nm to ~6.0 nm. The relaxivity was found to increase with the increased size of the AuNPs. Secondly, polyelectrolyte coating of charged Gd-loaded AuNPs surface also resulted in increase of relaxivity due to better immobilisation of the Gd3+ ions. Gold nanoparticles were also used as templates for nitroxide based redox sensitive MRI contrast agents. The reducing behaviour and relaxivity of nitroxide protected AuNPs was measured and found slightly better than that of free nitroxide. Finally other useful applications of nanoparticles protected by DTPA based ligand were explored. For example, the DTPA ligand can also chelate strongly with other lanthanides such as Eu3+, Tb3+etc. The luminescence measurements of lanthanides (Eu3+ and Tb3+) loaded onto AuNPs were explored. Lanthanide-loaded AuNPs were also used as model compounds to test an important EPR methodology after labelling with a nitroxide based spin label.
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Chen, Yu-Su. "Phosphonium-functionalised gold nanoparticles for mitochondria targeted therapeutics." Thesis, Sheffield Hallam University, 2014. http://shura.shu.ac.uk/19454/.

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The work presented in this thesis demonstrates that triarylphosphoniopropyl-thiosulfate zwitterions and w-thioacetylpropyl(triphenyl)phosphonium salts can be used to prepare cationic, water-soluble gold nanoparticles with mean core sizes in the range of 2.5-5 nm. Phosphonium-functionalised gold nanoparticles have been characterised by a number of techniques including NMR, LDI-MS, SIMS, XPS, TGA, ICP-MS, MALDI-MS and TEM.Cytotoxicity studies illustrated that phosphonium ligands are relatively non-toxic to human prostate cancer cells and therefore can be used as a delivery vector to delivery gold nanoparticles specifically to the site of the mitochondria for other therapeutic applications such as photothermal therapy. Cellular uptake studies of phosphonium ligands by MALDI-MS showed that they are rapidly taken-up by cells within ten minutes. Phosphonium-functionalised gold nanoparticles are soluble in biological media which is of great importance for cell biology studies. Initial photothermal therapy studies demonstrated that the gold nanoparticles responds specifically to a green light excitation source (510-550 nm) which overlaps the surface plasmon resonance band of the phosphonium-functionalised gold nanoparticles at 525 nm. Preliminary data also showed that phosphonium-functionalised gold nanoparticles can selectively induce apoptosis in cells followed by irradiation, this was confirmed by Hoechst and caspase-3 staining. Quantification studies of phosphonium-functionalised gold nanoparticles by ICP-MS illustrated that these nanoparticle have good uptake in cells (above 75%). TEM data confirmed that phosphonium-functionalised gold nanoparticles are taken-up by human prostate cancer cells and are localised in the mitochondria.
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António, Maria de Almeida Vasconcelos. "Detection of C-reactive protein using functionalized gold nanoparticles." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22538.

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Mestrado em Biotecnologia
Este projeto teve como objetivo desenvolver novas estratégias para funcionalizar nanopartículas de ouro (Au NPs) de forma a detetar a proteína C-reativa (CRP). Assim, foram sintetizadas nanopartículas de ouro esféricas com tamanhos médios de aproximadamente 10 e 40 nm. Posteriormente, a superfície das Au NPs foi modificada utilizando duas abordagens diferentes. Na primeira abordagem as Au NPs estabilizadas com citrato foram funcionalizadas com grupos ácidos carboxílicos pela modificação da superfície com os ligandos: ácido 11-mercaptoundecanóico (MUDA) e ácido mercaptopropiónico (MPA). Posteriormente a citidina difosfocolina (CDP) foi acoplada covalentemente à superfície das Au NPs utilizando 1-etil-3-(3’- dimetilaminopropil)carbodiimida (EDC) para promover a reação. Na segunda abordagem as Au NPs estabilizadas com citrato foram modificadas com um aptâmero específico para a CRP. Estes materiais foram caracterizados utilizando diversas técnicas de análise nomeadamente espectroscopia de UVvis e de infravermelho (FTIR), medidas de potencial Zeta e de diâmetro hidrodinâmico e microscopia eletrónica de transmissão (TEM). Amostras selecionadas de Au NPs modificadas com aptâmero (Au NPs@ssDNA+NaCl+KCl) e de Au NPs bioconjugadas com CDP (Au NPs@MUDA@CDP_40nm e Au NPs@MPA@CDP_10nm) foram utilizadas para o estudo da deteção da proteína: CRP. As Au NPs foram adicionadas a soluções de concentração conhecida (10 - 100 nM). A deteção da CRP foi investigada através da aquisição de espectros de UV-vis. O aumento da razão de agregação, isto é entre a absorvância a 620 nm e a absorvância da banda de ressonância de plasmão de superfície localizada (A620/ALSPR), foi monitorizada ao longo do tempo, indiciando a deteção da CRP para todas as amostras testadas. Para os sistemas Au NPs@MUDA@CDP_40nm e Au NPs@ssDNA+NaCl+KCl foi possível correlacionar a razão A620/ALSPR com a concentração da CRP através de uma relação linear nas gamas de concentração de 20 - 50 nM (R2=0.9425) e de, 20 - 45 nM (R2=0.9382) respetivamente. Os resultados obtidos, embora preliminares, são promissores sendo necessário avaliar em estudos futuros aspetos tais como reprodutibilidade e interferência de outras proteínas em estudos futuros, tendo em vista o desenvolvimento de biossensores válidos para a deteção de CRP
The main goal of this project was to develop novel strategies for the functionalization of gold nanoparticles (Au NPs) aiming the detection of Creactive protein (CRP). Au NPs with an average size of 10 and 40 nm were synthesized. Then, the surface of Au NPs was modified following two different approaches. The first approach consisted on the surface functionalization of citrate stabilized Au NPs with carboxylic acid groups, by surface modification using 11-mercaptoundecanoic acid (MUDA) and mercaptopropionic acid (MPA). The cytidine diphosphocholine (CDP) was covalently attached to the surface of functionalized Au NPs using 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride (EDC) to promote the coupling reaction. In the second approach, citrate stabilized Au NPs were modified with a CRP specific aptamer. These materials were characterized using several analysis techniques namely UV-vis spectroscopy, infra-red spectroscopy (F-T IR), zeta potential and hydrodynamic diameter measurements and transmission electron microscopy (TEM). Selected samples of Au NPs modified with aptamer (Au NPs@ssDNA+NaCl+KCl) and CDP bioconjugated Au NPs (Au NPs@MUDA@CDP_40nm e Au NPS@MPA@CDP_10nm) were used for studying CRP detection. Au NPs samples were added to CRP solutions of known concentration (10-100 nM). The detection was measured through acquisition of the UV-vis spectra. The increase of aggregation ratio between absorbance at 620 nm and the absorbance of localized surface plasmon resonance band (A620/ALSPR) was monitored along time and, indicated that CRP was detected for all the Au NPs samples tested. For the systems Au NPs@MUDA@CDP_40nm and Au NPs@ssDNA+NaCl+KCl it was possible to find a linear correlation between the ratio A620/ALSPR and the CRP concentration, within the concentration range 20 - 50 nM (R2=0.9425) and, 20 - 45 nM (R2=0.9382), respectively. The results obtained are very promising but still preliminary. Further studies are needed to evaluate key aspects such as reproducibility and interference of other proteins, keeping as main objective the development of valid biosensors for CRP detection.
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Zoppi, A., J. R. Molina-Contreras, P. Marsili, M. Muniz-Miranda, G. Margheri, S. Trigari, A. Leva, E. Giorgetti, and F. Giammanco. "Glutathione-Induced Release of Zeatin From Functionalized Gold Nanovectors." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/42489.

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The paper shows our preliminary results on the different spectroscopic behavior of three types of gold nanoparticles (obtained respectively by chemical synthesis, laser ablation in pure water and laser ablation in a citrate solution) modified with trans-zeatin, a plant growth regulator, in presence of glutathione. The reaction of ligand substitution of the adsorbed zeatin with glutathione is studied through surface enhanced Raman spectroscopy and is revealed to occur only when citrate-laser ablated gold nanoparticles are employed, making these particles potentially good candidates as vehicles of zeatin inside plant cells for future agricultural applications.
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Books on the topic "Functionalized gold nanoparticle"

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Selegård, Robert. Polypeptide functionalized gold nanoparticles for bioanalytical applications. Linköping University Electronic Press, 2014. http://dx.doi.org/10.3384/diss.diva-106719.

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Book chapters on the topic "Functionalized gold nanoparticle"

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Soto, Carissa M., and Walter J. Dressick. "Dual-Functionalized Virus–Gold Nanoparticle Clusters for Biosensing." In Methods in Molecular Biology, 533–52. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7808-3_34.

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Thimiri Govinda Raj, Deepak B., Niamat Ali Khan, Srisaran Venkatachalam, Sivakumar Arumugam, and Selvamani Palaniswamy. "Synthesis of Hybrid Gold Nanoparticle (AuNP) Functionalized Superparamagnetic Nanoparticles (SPMNPs) for Efficient Coupling of Biomolecules." In Methods in Molecular Biology, 73–75. New York, NY: Springer US, 2019. http://dx.doi.org/10.1007/7651_2019_254.

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Ye, Weiwei, and Mo Yang. "A Functionalized Nanoporous Alumina Membrane Electrochemical Sensor for DNA Detection with Gold Nanoparticle Amplification." In Ceramic Transactions Series, 191–97. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118771587.ch18.

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Lopez, Anand, and Juewen Liu. "DNA-Functionalized Gold Nanoparticles." In 21st Century Nanoscience – A Handbook, 10–1. Boca Raton, Florida : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429351525-10.

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Xiang, Yu, Peiwen Wu, Li Huey Tan, and Yi Lu. "DNAzyme-Functionalized Gold Nanoparticles for Biosensing." In Advances in Biochemical Engineering/Biotechnology, 93–120. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/10_2013_242.

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Li, Tao, Xiuxia He, and Zhenxin Wang. "The Application of Peptide Functionalized Gold Nanoparticles." In ACS Symposium Series, 55–68. Washington, DC: American Chemical Society, 2012. http://dx.doi.org/10.1021/bk-2012-1113.ch004.

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Wong, Alexis C., David W. Wright, and Joseph A. Conrad. "Functionalized Gold Nanoparticles for Detection of Cancer Biomarkers." In Biomarkers in Disease: Methods, Discoveries and Applications, 1143–75. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-7696-8_38.

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Wong, Alexis C., David W. Wright, and Joseph A. Conrad. "Functionalized Gold Nanoparticles for Detection of Cancer Biomarkers." In General Methods in Biomarker Research and their Applications, 1–26. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-7740-8_38-1.

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Della Ventura, B., R. Campanile, M. Cimafonte, V. Elia, A. Forente, A. Minopoli, E. Scardapane, C. Schiattarella, and R. Velotta. "Gold Coated Nanoparticles Functionalized by Photochemical Immobilization Technique for Immunosensing." In Lecture Notes in Electrical Engineering, 113–18. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69551-4_16.

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Ip, Alexander C. F., and Juewen Liu. "DNA-Functionalized Gold Nanoparticles for Metabolite and Nucleic Acid Detection." In DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases, 121–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-662-45775-7_5.

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Conference papers on the topic "Functionalized gold nanoparticle"

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Aidil, A., S. R. Balakrishnan, C. W. Zanariah, W. Z. Wan Ismail, M. Sahrim, I. Ismail, and J. Jamaludin. "Electrochemical Detection of Tributyrin using Gold Nanoparticle Functionalized Screen-Printed Electrode." In 2021 IEEE 19th Student Conference on Research and Development (SCOReD). IEEE, 2021. http://dx.doi.org/10.1109/scored53546.2021.9652783.

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Lee, K. G., H. W. Kihm, K. J. Ahn, Q.-Han Park, Ch Lienau, and D. S. Kim. "Local Vector Field Detection with Gold Nanoparticle Functionalized Tips: the Tip-Independence." In 2007 Conference on Lasers and Electro-Optics - Pacific Rim. IEEE, 2007. http://dx.doi.org/10.1109/cleopr.2007.4391275.

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Zhao, Fusheng, Suyan Qiu, Jingting Li, and Wei-Chuan Shih. "Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip." In SPIE BiOS, edited by Tuan Vo-Dinh and Joseph R. Lakowicz. SPIE, 2017. http://dx.doi.org/10.1117/12.2253011.

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Lueshen, Eric, Indu Venugopal, and Andreas Linninger. "Intrathecal Magnetic Drug Targeting: A New Approach to Treating Diseases of the Central Nervous System." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93117.

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Intrathecal (IT) drug delivery is a standard technique which involves direct injection of drugs into the cerebrospinal fluid (CSF)-filled space within the spinal canal to treat many diseases of the central nervous system. Currently, in order to reach the therapeutic drug concentration at certain locations within the spinal canal, high drug doses are used. With no method to deliver the large drug doses locally, current IT drug delivery treatments are hindered with wide drug distributions throughout the central nervous system (CNS) which cause harmful side effects. In order to overcome the current limitations of IT drug delivery, we have developed the novel method of intrathecal magnetic drug targeting (IT-MDT). Gold-coated magnetite nanoparticles are infused into a physiologically and anatomically relevant in vitro human spine model and then targeted to a specific site using external magnetic fields, resulting in a substantial increase in therapeutic nanoparticle localization at the site of interest. Experiments aiming to determine the effect of key parameters such as magnet strength, duration of magnetic field exposure, location of magnetic field, and ferrous implants on the collection efficiency of our superparamagnetic nanoparticles in the targeting region were performed. Our experiments indicate that intrathecal magnetic drug targeting and implant-assisted IT-MDT are promising techniques for concentrating and localizing drug-functionalized nanoparticles at required target sites within the spinal canal for potential treatment of diseases affecting the central nervous system.
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Nguyen, Van Phuc, Tianye Zhu, Wen Fan, Wei Qian, Yanxiu Li, Wei Zhang, Jessica Henry, Bing Liu, Xueding Wang, and Yannis M. Paulus. "In vivo multimodal photoacoustic microscopy and optical coherence tomography longitudinal tracking of progenitor cells labeled with functionalized chain-like gold nanoparticle clusters after ocular subretinal transplantation." In Photons Plus Ultrasound: Imaging and Sensing 2021, edited by Alexander A. Oraevsky and Lihong V. Wang. SPIE, 2021. http://dx.doi.org/10.1117/12.2577647.

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Zhao, Chen, Guowei Zhong, Da-Eun Kim, Jinxia Liu, and Xinyu Liu. "A Portable Analytical System for Colorimetric Detection of Metal Ions in Water." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38994.

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Heavy metal ions released into various water environments have severe impact on both human beings and aqueous environments, and excess amount of lead and aluminum ions pose high risks to human health and could cause life-threatened diseases. The existence of metal ions in drinking water contributes most to the daily intake by humans, and thus it urges to develop a rapid, low-cost and sensitive method for detection of heavy metal ions. In this research, we develop a portable analytical system for metal ion detection in water by combining a powerful gold nanoparticle (AuNP) based colorimetric method with lab-on-a-chip technology. We utilize single-step assays involving surface functionalized AuNPs for colorimetric detection of lead (Pb2+) and aluminum (Al3+) ions in water with low limit of detection (LOD) and high sensitivity. We demonstrate that this portable system provides LODs of 30 ppb for Pb2+ and 89 ppb for Al3+, both comparable to bench-top analytical spectrometers. The system permits metal ion detections in a more economical and convenient fashion, and is particularly useful for water quality monitoring in remote and/or resource-poor settings.
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Coelho, S. C., S. Rocha, M. Carmo Pereira, M. A. N. Coelho, and P. Juzenas. "Functionalized gold nanoparticles for drug delivery." In 2013 IEEE 3rd Portuguese Meeting in Bioengineering (ENBENG). IEEE, 2013. http://dx.doi.org/10.1109/enbeng.2013.6518389.

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Cohen, Moshik, Zeev Zalevsky, Salvador Pocoví-Martínez, Asaf Shahmoon, and Julia Pérez-Prieto. "Thermally controlled photocatalytic coalescence of functionalized gold nanoparticles." In SPIE Photonics Europe, edited by David L. Andrews, Jean-Michel Nunzi, and Andreas Ostendorf. SPIE, 2014. http://dx.doi.org/10.1117/12.2052001.

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Tzror-Azankot, Chen, Tamar Dreifuss, Tal-Shachar Ben-Gal, Avi Jacob, Tamar Sadan, Menachem Motiei, and Rachela Popovtzer. "Cellular internalization pathways of glucose-functionalized gold nanoparticles." In Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, edited by Dan V. Nicolau, Dror Fixler, and Ewa M. Goldys. SPIE, 2019. http://dx.doi.org/10.1117/12.2509605.

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Ebashi, Yoichi, Hideya Nakamura, and Satoru Watano. "Interaction of Functionalized Gold Nanoparticles with Lipid Bilayer." In 5th Asian Particle Technology Symposium. Singapore: Research Publishing Services, 2012. http://dx.doi.org/10.3850/978-981-07-2518-1_173.

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Reports on the topic "Functionalized gold nanoparticle"

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Cho, Tae Joon, and Vincent A. Hackley. Assessing the chemical and colloidal stability of functionalized gold nanoparticles. Gaithersburg, MD: National Institute of Standards and Technology, June 2018. http://dx.doi.org/10.6028/nist.sp.1200-26.

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