Dissertations / Theses on the topic 'Functional systems analysis'
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Schmelich, Volker, and Rainer Alt. "Functional Analysis of Open Source ERP Systems – An Exploratory Analysis." Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-81833.
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Während Open Source-Software wie etwa Linux, der Apace Webserver oder die OpenOffice-Suite eine grosse Verbreitung erfahren haben, sind Open Source-Lösungen zur Unterstützung betrieblicher Aufgaben weniger bekannt. Dieser Bericht unternimmt ausgehend von den funktionalen Anforderungen der Auftragsabwicklung eines Industrieunternehmens einen Vergleich bestehender Lösungen und diskutiert die Einsatzmöglichkeiten aus heutiger Sicht.
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Schmelich, Volker, and Rainer Alt. "Functional Analysis of Open Source ERP Systems – An Exploratory Analysis." Universität Leipzig, 2008. https://ul.qucosa.de/id/qucosa%3A11328.
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Während Open Source-Software wie etwa Linux, der Apace Webserver oder die OpenOffice-Suite eine grosse Verbreitung erfahren haben, sind Open Source-Lösungen zur Unterstützung betrieblicher Aufgaben weniger bekannt. Dieser Bericht unternimmt ausgehend von den funktionalen Anforderungen der Auftragsabwicklung eines Industrieunternehmens einen Vergleich bestehender Lösungen und diskutiert die Einsatzmöglichkeiten aus heutiger Sicht.:1 Introduction
2 Research Methodology
3 Functional Analysis of OS-ERP
3.1 Setting: A Manufacturing Company
3.2 Order Processing as Scenario for Comparison
3.3 Results of Comparison
3.4 Discussion of Results
4 Conclusions
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MacDonell, Stephen Gerard. "Quantitative functional complexity analysis of commercial software systems." Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/270422.
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Tan, Sofia. "Enhanced functional analysis system technique for managing complex engineering projects." Diss., Rolla, Mo. : University of Missouri-Rolla, 2007. http://scholarsmine.umr.edu/thesis/pdf/Tan_09007dcc803c4e70.pdf.
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Thesis (M.S.)--University of Missouri--Rolla, 2007.Vita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed November 27, 2007) Includes bibliographical references (p. 27-29).
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Adams, Anne Edith. "Understanding the skill of functional task analysis." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37313.
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Although widely used, little is known about the nature of expertise involved in functional task analysis, methods used to discover and represent a task structure in terms of goals and subgoals. Training studies indicated that learning task analysis is not trivial. To counter the "task analysis is an art" explanation, this dissertation approached task analysis as a skill acquisition problem that can be understood through scientific inquiry. Two studies were designed to capture and characterize experienced and novice performance. Professional (Study 1) and novice (Study 2) task analysts conducted task analyses on six tasks from two domains (cooking, communication). Master task analyses were created for each task and served as a basis for analysis. Some similar patterns to the task analysis products and errors were observed for the hierarchy dimensions (breadth and depth of analysis), subgoal focus, and versatility. However, differences in separating subgoals (verb-noun pairs) were observed and may be further investigated in the future. Future directions could also focus on understanding the association between the general approach (breadth and depth-first) and the characteristics of the task analysis products.
Skill components of functional task analysis were derived from the findings in both studies conducted for this dissertation.
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Nayfeh, Jamal Faris. "Nonlinear dynamics of composite plates and other physical systems." Diss., This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-07282008-135756/.
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Xu, Yiwen. "Reliability Analysis and Optimization of Systems Containing Multi-Functional Entities." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/594927.
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Enabling more than one function in an entity provides a new cost-effective way to develop a highly reliable system. In this dissertation, we study the reliability of systems containing multi-functional entities. We derive the expressions for reliability of one-shot systems and reliability of each function. A step further, a redundancy allocation problem (RAP) with the objective of maximizing system reliability is formulated. Unlike constructing a system with only single-functional entities, the number of copies of a specific function to be included in each multi-functional entity (i.e., functional redundancy) needs to be determined as part of the design. Moreover, a start-up strategy for turning on specific functions in these components must be decided prior to system operation. We develop a heuristic algorithm and include it in a two-stage Genetic Algorithm (GA) to solve the new RAP. We also apply a modified Tabu search (TS) method for solving such NP-hard problems. Our numerical studies illustrate that the two-stage GA and the TS method are quite effective in searching for high quality solutions. The concept of multi-functional entities can be also applied in probabilistic site selection problem (PSSP). Unlike traditional PSSP with failures either at nodes or on edges, we consider a more general problem, in which both nodes and edges could fail and the edge-level redundancy is included. We formulate the problem as an integer programming optimization problem. To reduce the searching space, two corresponding simplified models formulated as integer linear programming problems are solved for providing a lower bound to the primal problem. Finally, a big challenge in reliability analysis is how to determine the failure distribution of components. This is especially significant for multi-functional entities as more levels of redundancy are considered. We provide an automated model-selection method to construct the best phase-type (PH) distribution for a given data set in terms of the model complexity and the adequacy of statistical fitting. To efficiently utilize the Akaike Information Criterion for balancing the likelihood value and the number of free parameters, the proposed method is carried out in two stages. The detailed subproblems and the related solution procedures are developed and illustrated through numerical studies. The results verify the effectiveness of the proposed model-selection method in constructing PH distributions.
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Cole, David Michael. "Functional network analysis of human brain systems under pharmacological modulation." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10933.
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Complex alterations in brain function and neurochemistry underlie pathology and treatment in multiple neuropsychiatric disorders, yet remain incompletely characterised. This thesis outlines possibilities for human neuroimaging techniques sensitive to spontaneous fluctuations in large-scale neurobiological signalling, or ‘resting-state network (RSN) functional connectivity’, to address such knowledge gaps. Novel RSN-sensitive analysis approaches to functional magnetic resonance imaging data are introduced. These techniques are then evaluated experimentally, in contexts relevant for maladaptive cognitive and motivational processing, for their utility to identify and characterise systems-level signatures of individual differences in neurochemistry and psychopharmacological responsiveness. Firstly, RSN functional connectivity measures are investigated in the context of pharmacological intervention with nicotine replacement therapy in habitual smokers. Results identify connectivity between executive control and ‘default mode’ RSNs as a neural signature of pharmacotherapeutic efficacy in treating cognitive symptoms of nicotine withdrawal. Secondly, RSN connectivity is investigated alongside specific neuroreceptor-sensitive measures to investigate the extent to which network connectivity patterns reflect fundamental neurobiology in healthy subjects. Individual differences in dopamine D3 receptor availability - a possible marker for reward-related behaviours -are associated with topographic connectivity signatures within RSNs implicated in cognitive and motivational control. Thirdly, the ability of RSN metrics to characterise distinct neurochemical manipulations is tested in healthy subjects. Dopamine agnostic and antagonistic neuromodulations display differential effects on signalling in cortico-cubcortical and cortico-cortical reward circuitry and interact selectively with subject impulsivity. Finally, RSN cortico-subcortical connectivity metrics are investigated for their sensitivity to clinical-pharmacological effects in Parkinson’s disease. Results reveal evidence for both compensatory large-scale network mechanisms and ‘non-normalising’ dopaminergic medication effects in patients. Overall, findings indicate novel systems-level neuroimaging methodology probing interactions within and between RSNs to provide sensitive, biologically plausible markers for behavioural and neuropharamacological characteristics of neuropsychiatric disorders. Continued developments of functional network analysis approaches may facilitate their direct application to clinical and drug development domains.
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Bell, Jonathan. "Interpretation of simulation for model-based design analysis of engineered systems." Thesis, Aberystwyth University, 2006. http://hdl.handle.net/2160/05880836-32b8-4f65-abfe-9b0ecf16cc42.
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This thesis attempts to answer the question "Can we devise a language for interpretation of behavioural simulation of engineered systems (of arbitrary complexity) in terms of the systems’ purpose?" It does so by presenting a language that represents a device’s function as achieving some purpose if the device is in a state that is intended to trigger the function and the function’s expected effect is present. While most work in the qualitative and model-based reasoning community has been concerned with simulation, this language is presented as a basis for interpret- ing the results of the simulation of a system, enabling these results to be expressed in terms of the system’s purpose. This, in turn, enables the automatic production of draft design analysis reports using model based analysis of the subject system. The increasing behavioural complexity of modern systems (resulting from the increasing use of microprocessors and software) has led to a need to interpret the results of simulation in cases beyond the capabilities of earlier functional mod- elling languages. The present work is concerned with such cases and presents a functional modelling language that enables these complex systems to be analysed. Specifically, the language presented herein allows functional description and interpretation of the following. • Cases where it is desired to distinguish between partial and complete failure of a function. • Systems whose functionality depends on achieving a sequence of intermittent effects. • Cases where a function being achieved in an untimely manner (typically late) needs to be distinguished from a function failing completely. • Systems with functions (such as warning functions) that depend upon the state of some other system function. This offers significant increases both in the range of systems and of design analysis tasks for which the language can be used, compared to earlier work.
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Chang, Ken Kai-fu 1973. "Simulation of nonlinear optic-fibre communication systems using Volterra series transfer function techniques." Monash University, Dept. of Electrical and Computer Systems Engineering, 2002. http://arrow.monash.edu.au/hdl/1959.1/7758.
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Zhou, Rensheng. "Degradation modeling and monitoring of engineering systems using functional data analysis." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45897.
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In this thesis, we develop several novel degradation models based on techniques from functional data analysis. These models are suitable for characterizing different types of sensor-based degradation signals, whether they are censored at a certain fixed time point or truncated at the failure threshold. Our proposed models can also be easily extended to accommodate for the effects of environmental conditions on degradation processes. Unlike many existing degradation models that rely on the existence of a historical sample of complete degradation signals, our modeling framework is well-suited for modeling complete as well as incomplete (sparse and fragmented) degradation signals. We utilize these models to predict and continuously update, in real time, the residual life distributions of partially degraded components. We assess and compare the performance of our proposed models and existing benchmark models by using simulated signals and real world data sets. The results indicate that our models can provide a better characterization of the degradation signals and a more accurate prediction of a system's lifetime under different signal scenarios. Another major advantage of our models is their robustness to the model mis-specification, which is especially important for applications with incomplete degradation signals (sparse or fragmented).
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Oscarsson, Joakim. "Functional Safety in Co-operative Driving using Systems-Theoretic Process Analysis." Thesis, KTH, Maskinkonstruktion (Inst.), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-201094.
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Kooperativ körning är fenomenet av uppkopplade väg fordon som utbyter information för att uppnå säkrare och mer effektiva trafiksituationer. Det är en invecklad kontext som ger nya synvinklar på området funktionell säkerhet. Det kan automatiseras, och då autonoma fordon är beroende av pålitlig information för att kunna fatta beslut, så uppstår frågan med tillit till datamottagen genom kooperativa körningskanaler. Även bortsatt från området datasäkerhet, finns fortfarande en risk att brister i andra fordon kan orsaka att inkommande kommunikationssignaler ej blir trovärdiga. I det här examensarbetet visas att antaganden om nivån av tillförlitlighet till data från externa fordon kan ha en signifikant påverkan på den slutgiltiga arkitekturen. Det visas också att det varken att fullt lita på, eller att inte alls lita på data mottagen genom kooperativa körningskanaler, är optimalt när hänsyn tas till säkerhet, nyttjande av kommunikationsmöjligheter och kostnader. På grund av komplexiteten i kooperativ körning utförs analyserna med den nya och tillsynes lovande metoden System-teoretisk process analys (STPA). För tillfället är det praxis inom fordonsindustrin att för funktionell säkerhet rätta sig till standarden ISO 26262, som inte ger någon naturlig väg att implementera STPA. Därför presenterar detta examensarbete en utvecklingsprocess som nyttjar fördelarna med STPA och rättar sig efter ISO 26262 standarden. STPA har störst potential under produktutveckling vid system design, men även andra användningsområden har identifierats. STPA är en modern, generell analysmetod som aldrig tidigare används i kontexten kooperativ körning. Därför inleder detta examensarbete med att validera dess tillämpbarhet i denna specifika kontext. Utvärderingen utförs genom en studie av ett verkligt fall, kopplat till KTHs deltagande i Grand Cooperative Driving Challenge - en tävling av i-GAME, menat att snabba på implementeringen av kooperativ körning i Europa. Metodens validitet i kontexten styrks av fler än en analytiker, utvecklingsteamet för kooperativ körning på KTH, en klients godkännande av resultat, samt av akademisk granskning.Co-operative driving is the phenomenon of connected road vehicles exchanging information to achieve safer and more efficient traffic. It is a convoluted context, which gives the topic of functional safety new complex angles. It can be automated, and as autonomous vehicles are dependent on reliable information for decision making, the issue of trusting data received over co-operation communication channels is raised. Disregarding the topic of security, there is still the possibility of failures in external vehicles causing incoming transmissions to be untrustworthy. In this thesis, it is shown that premises regarding levels of external trust can have significant impacts on the final architecture. It is also shown that neither fully trusting, nor not trusting data received over co-operation communication channels is the best option, when considering safety, usage of communication potential and cost. Because of the complexity of co-operative driving, the analyses are performed using the new and promising method of Systems-Theoretic process analyses (STPA). The current best practice of automotive functional safety is to comply with the domain specific ISO 26262 standard, which does not provide a natural way of implementing STPA. Therefore, this thesis also presents a development process which utilises the benefits of STPA, while complying to the ISO 26262 standard. STPA has the greatest potential during the product development at system level, though other uses have also been identified. STPA is a generic analysis method, which has previously not been used in the context of cooperative driving. This thesis therefor begins by validating the applicability of STPA in this specific context. The evaluation is performed using a real world case study connected to KTH’s participation in the Grand Cooperative Driving Challenge - a competition by i-GAME to speed up the implementation of co-operative driving in Europe. The validity of the method when applied to this context is strengthened by multiple analysts, the KTH co-operative driving development team, client approval of results and academic reviews.
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Hayashi, Koji. "Functional Analysis of Mammalian Cytochromes P450 by Using Heterologus Expression Systems." Kyoto University, 2001. http://hdl.handle.net/2433/150789.
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Ku, Hyunchul. "Behavioral modeling of nonlinear RF power amplifiers for digital wireless communication systems with implications for predistortion linearization systems." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04052004-180035/unrestricted/ku%5Fhyunchul%5F200312%5Fphd.pdf.
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Leung, Tsui-shan. "A functional analysis of GIS for slope management in Hong Kong /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22032447.
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Saadatmand, Mehrdad. "Preservation of Extra-Functional Properties in Embedded Systems Development." Doctoral thesis, Mälardalens högskola, Inbyggda system, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-27300.
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The interaction of embedded systems with their environments and their resource limitations make it important to take into account properties such as timing, security, and resource consumption in designing such systems. These so-called Extra-Functional Properties (EFPs) capture and describe the quality and characteristics of a system, and they need to be taken into account from early phases of development and throughout the system's lifecycle. An important challenge in this context is to ensure that the EFPs that are defined at early design phases are actually preserved throughout detailed design phases as well as during the execution of the system on its platform. In this thesis, we provide solutions to help with the preservation of EFPs; targeting both system design phases and system execution on the platform. Starting from requirements, which form the constraints of EFPs, we propose an approach for modeling Non-Functional Requirements (NFRs) and evaluating different design alternatives with respect to the satisfaction of the NFRs. Considering the relationship and trade-off among EFPs, an approach for balancing timing versus security properties is introduced. Our approach enables balancing in two ways: in a static way resulting in a fixed set of components in the design model that are analyzed and thus verified to be balanced with respect to the timing and security properties, and also in a dynamic way during the execution of the system through runtime adaptation. Considering the role of the platform in preservation of EFPs and mitigating possible violations of them, an approach is suggested to enrich the platform with necessary mechanisms to enable monitoring and enforcement of timing properties. In the thesis, we also identify and demonstrate the issues related to accuracy in monitoring EFPs, how accuracy can affect the decisions that are made based on the collected information, and propose a technique to tackle this problem. As another contribution, we also show how runtime monitoring information collected about EFPs can be used to fine-tune design models until a desired set of EFPs are achieved. We have also developed a testing framework which enables automatic generation of test cases in order verify the actual behavior of a system against its desired behavior. On a high level, the contributions of the thesis are thus twofold: proposing methods and techniques to 1) improve maintenance of EFPs within their correct range of values during system design, 2) identify and mitigate possible violations of EFPs at runtime.CHESS
MBAT
ITS-EASY
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Rieger, Karl. "Analysis and control of infinite dimensional systems a geometric and functional analytic approach." Aachen Shaker, 2008. http://d-nb.info/993663737/04.
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Flöttmann, Max. "Functional analysis of High-Throughput data for dynamic modeling in eukaryotic systems." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16809.
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Das Verhalten Biologischer Systeme wird durch eine Vielzahl regulatorischer Prozesse beeinflusst, die sich auf verschiedenen Ebenen abspielen. Die Forschung an diesen Regulationen hat stark von den großen Mengen von Hochdurchsatzdaten profitiert, die in den letzten Jahren verfügbar wurden. Um diese Daten zu interpretieren und neue Erkenntnisse aus ihnen zu gewinnen, hat sich die mathematische Modellierung als hilfreich erwiesen. Allerdings müssen die Daten vor der Integration in Modelle aggregiert und analysiert werden. Wir präsentieren vier Studien auf unterschiedlichen zellulären Ebenen und in verschiedenen Organismen. Zusätzlich beschreiben wir zwei Computerprogramme die den Vergleich zwischen Modell und Experimentellen Daten erleichtern. Wir wenden diese Programme in zwei Studien über die MAP Kinase (MAP, engl. mitogen-acticated-protein) Signalwege in Saccharomyces cerevisiae an, um Modellalternativen zu generieren und unsere Vorstellung des Systems an Daten anzupassen. In den zwei verbleibenden Studien nutzen wir bioinformatische Methoden, um Hochdurchsatz-Zeitreihendaten von Protein und mRNA Expression zu analysieren. Um die Daten interpretieren zu können kombinieren wir sie mit Netzwerken und nutzen Annotationen um Module identifizieren, die ihre Expression im Lauf der Zeit ändern. Im Fall der humanen somatischen Zell Reprogrammierung führte diese Analyse zu einem probabilistischen Boolschen Modell des Systems, welches wir nutzen konnten um neue Hypothesen über seine Funktionsweise aufzustellen. Bei der Infektion von Säugerzellen (Canis familiaris) mit dem Influenza A Virus konnten wir neue Verbindungen zwischen dem Virus und seinem Wirt herausfinden und unsere Zeitreihendaten in bestehende Netzwerke einbinden. Zusammenfassend zeigen viele unserer Ergebnisse die Wichtigkeit von Datenintegration in mathematische Modelle, sowie den hohen Grad der Verschaltung zwischen verschiedenen Regulationssystemen.The behavior of all biological systems is governed by numerous regulatory mechanisms, acting on different levels of time and space. The study of these regulations has greatly benefited from the immense amount of data that has become available from high-throughput experiments in recent years. To interpret this mass of data and gain new knowledge about studied systems, mathematical modeling has proven to be an invaluable method. Nevertheless, before data can be integrated into a model it needs to be aggregated, analyzed, and the most important aspects need to be extracted. We present four Systems Biology studies on different cellular organizational levels and in different organisms. Additionally, we describe two software applications that enable easy comparison of data and model results. We use these in two of our studies on the mitogen-activated-protein (MAP) kinase signaling in Saccharomyces cerevisiae to generate model alternatives and adapt our representation of the system to biological data. In the two remaining studies we apply Bioinformatic methods to analyze two high-throughput time series on proteins and mRNA expression in mammalian cells. We combine the results with network data and use annotations to identify modules and pathways that change in expression over time to be able to interpret the datasets. In case of the human somatic cell reprogramming (SCR) system this analysis leads to the generation of a probabilistic Boolean model which we use to generate new hypotheses about the system. In the last system we examined, the infection of mammalian (Canis familiaris) cells by the influenza A virus, we find new interconnections between host and virus and are able to integrate our data with existing networks. In summary, many of our findings show the importance of data integration into mathematical models and the high degree of connectivity between different levels of regulation.
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Shah, Riddhi. "Functional analysis of Group 2 chaperonins from archaeal species in E. coli." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4957/.
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The chaperonin proteins form a ubiquitous family of molecular chaperones and are absolutely required for correct folding or assembly of a subset of proteins in the cell. They are divided into two groups based on phylogeny: Group 1 found in bacteria and eukaryotic-organelles and Group 2 found in eukaryotic-cytoplasma and archaea. The two groups share a significant degree of conservation but differ in structure and mechanism and are believed to have evolved to serve specific client proteins. Using archaeal chaperonin from M. maripaludis (MmCCT) as a representative, we report here for the first time that a Group 2 chaperonin can partially replace the function of a Group 1 chaperonin from E. coli (GroEL). We have also identified and characterized two functional variants of MmCCT that show better GroEL complementation and have utilized them for a preliminary mutational analysis of potential client binding residues of MmCCT. We further demonstrate an initiative using a tagging approach for identification of bacterial proteins that interact with MmCCT in vivo. We suggest that our findings provide a novel platform for genetic dissection of MmCCT using a comparatively simple host, E. coli, which in turn can help identify properties of this archaeal chaperonin and provide insights for structure-function co-relations of Group 2 chaperonins in general.
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Hanauer, Maria [Verfasser], and Peter [Akademischer Betreuer] Poschlod. "Comparative ecological and functional analysis of grazing systems / Maria Hanauer. Betreuer: Peter Poschlod." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1085551873/34.
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Sharif, Asif. "A functional analysis of building procurement systems and strategies in an international context." Thesis, Nottingham Trent University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337534.
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Hirose, Takayuki. "Envisioning Emergent Behaviors of Socio-Technical Systems Based on Functional Resonance Analysis Method." Kyoto University, 2020. http://hdl.handle.net/2433/259040.
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付記する学位プログラム名: デザイン学大学院連携プログラムKyoto University (京都大学)
0048
新制・課程博士
博士(工学)
甲第22772号
工博第4771号
新制||工||1746(附属図書館)
京都大学大学院工学研究科機械理工学専攻
(主査)教授 椹木 哲夫, 教授 松原 厚, 教授 小森 雅晴
学位規則第4条第1項該当
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Fujita, Miki. "FUNCTIONAL ANALYSIS OF GENE PRODUCTS OF PLANT VIRUSES BY USING PROTEIN EXPRESSION SYSTEMS." Kyoto University, 2000. http://hdl.handle.net/2433/181036.
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Kyoto University (京都大学)0048
新制・課程博士
博士(農学)
甲第8407号
農博第1091号
新制||農||797(附属図書館)
学位論文||H12||N3364(農学部図書室)
UT51-2000-F311
京都大学大学院農学研究科応用生物科学専攻
(主査)教授 古澤 巌, 教授 久野 英二, 教授 津田 盛也
学位規則第4条第1項該当
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Vasconcelos, Pedro B. "Space cost analysis using sized types." Thesis, University of St Andrews, 2008. http://hdl.handle.net/10023/564.
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Programming resource-sensitive systems, such as real-time embedded systems, requires guaranteeing both the functional correctness of computations and also that time and space usage fits within constraints imposed by hardware limits or the environment. Functional programming languages have proved very good at meeting the former logical kind of guarantees but not the latter resource guarantees. This thesis contributes to demonstrate the applicability of functional programming in resource-sensitive systems with an automatic program analysis for obtaining guaranteed upper bounds on dynamic space usage of functional programs. Our analysis is developed for a core subset of Hume, a domain-specific functional language targeting resource-sensitive systems (Hammond et al. 2007), and presented as a type and effect system that builds on previous sized type systems (Hughes et al. 1996, Chin and Khoo 2001) and effect systems for costs (Dornic et al. 1992, Reistad and Giord 1994, Hughes and Pareto 1999). It extends previous approaches by using abstract interpretation techniques to automatically infer linear approximations of the sizes of recursive data types and the stack and heap costs of recursive functions. The correctness of the analysis is formally proved with respect to an operational semantics for the language and an inference algorithm that automatically reconstructs size and cost bounds is presented. A prototype implementation of the analysis and operational semantics has been constructed and used to experimentally assess the quality of the cost bounds with some examples, including implementations of textbook functional programming algorithms and simplified embedded systems.
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Anders, Shilo H. "Projecting trajectories of functional use for a new technology the electronic ICU /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1213369071.
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Kästner, Christopher Niels. "Functional analysis and single-molecule fluorescence spectroscopy of citrate transport systems from Klebsiella pneumoniae /." Zürich, 2001. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14370.
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Tisell, Claes. "Integration of database technology and multibody system analysis." Doctoral thesis, Stockholm, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3041.
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Leung, Tsui-shan, and 梁翠珊. "A functional analysis of GIS for slope management in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31223072.
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Ankers, John-Mark. "An interdisciplinary analysis of physical and functional interactions between the NF-kappaB and E2F systems." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501724.
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n the post-genomic era oi biological research, integrative studies, examining how lowlevel biological components re-assemble into organised systems are becoming mcreasingly common. Integrative approaches of the past have often been limited by the complexity ot systems ot interest and by the techniques available to visualise' and quantify biological events. Recently there have been significant advances in techniques to measure dynamic and complex intra-cellular phenomena. Importantly, these have included higher-throughput, quantitative experimental approaches using fluorescent protein fusions. It is now possible to take advantage of such quantitative data to construct mathematical models that are capable of simulating the complexities found in many dynamical systems. The success of future systems-level studies lies in the strength of such interdisciplinary approaches.
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Prince, Samantha. "Mutation analysis of Wolfram syndrome patients and functional study of the wolframin protein." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3760/.
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Mutations of the WFS1 gene are responsible for most cases of Wolfram syndrome (WS), a rare, recessively inherited neurodegenerative disorder characterised by juvenile-onset non-autoimmune diabetes mellitus and optic atrophy. Variants of WFS1 are also associated with non-syndromic hearing loss and type-2 diabetes. Understanding the function of the WFS1 protein-product wolframin, would enable developments in targeted therapy for WS patients and important insights to its possible contribution to type-2 diabetes pathogenesis. This study was aimed at expanding the spectrum of WS-associated genetic mutations and clinical data, and investigating the molecular mechanisms responsible for phenotypic variation associated with WFS1-mutation. The mutational and phenotypic spectrum of WS is broadened by our report of novel WFS1 mutations and a case of WFS2-associated WS. New perspectives on the molecular mechanisms linking mutation to disease manifestation are also taken by characterisation of representative WFS1 mutations specific to phenotype, identification of potentially novel WFS1 interacting partners, and the first evidence linking WFS1 with the exocrine pancreas. Our data suggests that some WFS1-mutations may allow residual protein function and these findings lay the groundwork for future functional investigation of mutated wolframin to explore this hypothesis further.
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Flodmark, Erik, and Carl Sävendahl. "Managing a digital transformation : A case study of digitizing functional operations in a sociotechnical system." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-300385.
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Sweden has the ambition to be the world leading country leveraging the opportunities of digitalization in the healthcare sector. In parallel, the Swedish Research Council highlights that conducting more clinical studies is essential to improve the healthcare. Henceforth, considering the need for increased operational efficiency as an enabler for increased clinical activity, a digital transformation of the industry was identified as a potential catalyst. The study thus utilizes a cognitive work analysis framework to investigate the potential benefits and risks of digitizing the functional operations at a contract management department for clinical studies at a Swedish university hospital. The aim is thereafter to determine the appropriate properties necessary to consider managing a digital transformation. The analysis identified three key benefits from a digitization. 1) transparent data sharing, 2) standardized contract management and 3) efficient operations. These three aspects are currently insufficient at the department hindering the objective of increasing the clinical activity. The study found that a digital transformation would be suitable in order to mitigate these insufficiencies and consequently facilitating the achievement of the objectives. Thereafter, the study found the key properties to consider managing a digital transformation to be interoperability, quality, adaptability and usability. In addition, safety was found critical to be considered in the transformation as the contract management department acts under rigid laws and regulations on ethics and patient security with which digitized processes must comply. The results contribute to the field of cognitive systems engineering. However, the study has limitations regarding the reliability and generalizability of the results. The findings are based on a single case study, which may not be representative for the industry in general nor for university hospitals in particular. In addition, since no actual digitalization effort was performed at the organization during the study, appropriate properties key to consider in the digital transformation are speculative by design. Consequently, it is necessary to study an actual implementation process in future research and whether the proposed considerations are sufficient in order to realize the suggested benefits of such a digitalization.Sverige har ett övergripande mål att vara det ledande landet när det gäller att dra nytta av digitaliseringens möjligheter inom sjukvården. Dessutom understryker Vetenskapsrådet att det är centralt för förbättrad sjukvård att öka antalet kliniska studier i landet. Följaktligen, med tanke på behovet av en ökad operativ effektivitet, identifierade författarna det av intresse att studera digitalisering av branschen. Studien tillämpar således ett kognitivt ramverk för arbetsanalys i syfte att undersöka de potentiella fördelarna eller riskerna med att digitalisera den funktionella verksamheten hos en kontrakthanteringsavdelning för kliniska studier vid ett stort svenskt universitetssjukhus. Målsättningen är därefter att ta fram lämpliga egenskaper som är nödvändiga att beakta vid hanteringen av den digitala transformationen. Kontrakthanteringsavdelningen fanns att inneha brister i sina arbetsprocesser gällande transparens, effektivitet och standardisering vilket hindrar målet avseende ökad klinisk aktivitet. Studien visade att en digital transformation skulle vara nödvändig för att motverka dessa brister, samt för att möjliggöra en uppskalning av organisationen. Ett annat specifikt förbättringsområde som skulle underlättas av en digital transformation visade sig vara förbättrad synkronisering mellan arbetsprocesser. Vidare fann studien att de mest kritiska egenskaperna nödvändiga att beakta, vid hantering av en digital transformation, skulle vara interoperabilitet, kvalitet, anpassningsförmåga och användbarhet. Dessutom är säkerhet en egenskap som visat sig vara kritisk att beakta vid digitalisering då kontrakthanteringsavdelningen lyder under stränga lagar och föreskrifter beträffande etik och patientsäkerhet. Resultaten bidrar till forskningsområdet cognitive systems engineering. Studien har dock vissa begränsningar gällande tillförlitlighet och generaliserbarhet. Resultaten är baserade på en enfallstudie, som eventuellt inte är representativ för branschen i allmänhet eller för universitetssjukhus i synnerhet. Dessutom, då ingen digitaliseringsinsats utfördes under studien är de viktiga egenskaperna att beakta i den digitala transformationen enbart spekulativa. Således är det i framtida forskning viktigt att studera en faktisk implementation och då studera om föreslagna beaktanden är tillräckliga för att utnyttja digitaliseringens möjligheter.
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Abeto, Benjamin. "An Application of Systems Engineering to Analyze the Interagency Coordination Aspect of Counter Trafficking and Terrorism." Thesis, Monterey, California: Naval Postgraduate School, 2012. http://hdl.handle.net/10945/7286.
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This thesis utilizes principles of the systems engineering process discussed by Dennis Buede in â The Engineering Design of Systems: Models and Methods (2nd ed.)â (2009). The systems engineering process is used to create a functional architecture to analyze interagency coordination in support of counterterrorism efforts in the United States European Command area of operation. The resulting functional architecture serve as tools for policymakers as they determine the best ways to create a synchronous whole of government approach to defend United States interests.
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Paszkowski-Rogacz, Maciej. "Integration and analysis of phenotypic data from functional screens." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-63063.
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Motivation: Although various high-throughput technologies provide a lot of valuable information, each of them is giving an insight into different aspects of cellular activity and each has its own limitations. Thus, a complete and systematic understanding of the cellular machinery can be achieved only by a combined analysis of results coming from different approaches. However, methods and tools for integration and analysis of heterogenous biological data still have to be developed.
Results: This work presents systemic analysis of basic cellular processes, i.e. cell viability and cell cycle, as well as embryonic stem cell pluripotency and differentiation. These phenomena were studied using several high-throughput technologies, whose combined results were analysed with existing and novel clustering and hit selection algorithms.
This thesis also introduces two novel data management and data analysis tools. The first, called DSViewer, is a database application designed for integrating and querying results coming from various genome-wide experiments. The second, named PhenoFam, is an application performing gene set enrichment analysis by employing structural and functional information on families of protein domains as annotation terms. Both programs are accessible through a web interface.
Conclusions: Eventually, investigations presented in this work provide the research community with novel and markedly improved repertoire of computational tools and methods that facilitate the systematic analysis of accumulated information obtained from high-throughput studies into novel biological insights.
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Victor, Sjölin. "Putting a FRAMe on the VTS : A systems analysis of the Vessel Traffic Service using the Functional Resonance Analysis Method." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96395.
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The Vessel Traffic Service (VTS) is a complex system tasked with ensuring the safety of navigation within specified areas known as VTS areas. Earlier research in the domain has often focused on the decision support systems and other tools employed by the VTS operators to provide the vessels in the area with VTS services. Consequently, less effort has gone into looking at the system itself and the human factors aspects of the system. This study uses the Functional Resonance Analysis Method (FRAM) to create a functional model of the VTS. It looks at how a VTS works, what the different components are and how these components are related. The main purpose of the FRAM model is to serve as a basis for future application by identifying the functions that constitute the system, and to illuminate the potential variability therein. To demonstrate how it might be used, an instantiation of an observed scenario will be presented. A structural description of the VTS is also presented, which aims to serve as an introduction to the domain for readers who are previously unfamiliar with it. The functional model shows that a lot of the potential variability seems to lie in the functions that rely heavily on human interaction, which is to be expected, as human performance is highly variable. It also shows that the availability and reliability of relevant information is crucial in order to be able to provide the VTS services, and if the information for some reason is unavailable or insufficient it seems likely to cause variability.
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Poirel, Christopher L. "Bridging Methodological Gaps in Network-Based Systems Biology." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/23899.
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Functioning of the living cell is controlled by a complex network of interactions among genes, proteins, and other molecules. A major goal of systems biology is to understand and explain the mechanisms by which these interactions govern the cell's response to various conditions. Molecular interaction networks have proven to be a powerful representation for studying cellular behavior. Numerous algorithms have been developed to unravel the complexity of these networks. Our work addresses the drawbacks of existing techniques. This thesis includes three related research efforts that introduce network-based approaches to bridge current methodological gaps in systems biology.
i. Functional enrichment methods provide a summary of biological functions that are overrepresented in an interesting collection of genes (e.g., highly differentially expressed genes between a diseased cell and a healthy cell). Standard functional enrichment algorithms ignore the known interactions among proteins. We propose a novel network-based approach to functional enrichment that explicitly accounts for these underlying molecular interactions. Through this work, we close the gap between set-based functional enrichment and topological analysis of molecular interaction networks.
ii. Many techniques have been developed to compute the response network of a cell. A recent trend in this area is to compute response networks of small size, with the rationale that only part of a pathway is often changed by disease and that interpreting small subnetworks is easier than interpreting larger ones. However, these methods may not uncover the spectrum of pathways perturbed in a particular experiment or disease. To avoid these difficulties, we propose to use algorithms that reconcile case-control DNA microarray data with a molecular interaction network by modifying per-gene differential expression p-values such that two genes connected by an interaction show similar changes in their gene expression values.
iii. Top-down analyses in systems biology can automatically find correlations among genes and proteins in large-scale datasets. However, it is often difficult to design experiments from these results. In contrast, bottom-up approaches painstakingly craft detailed models of cellular processes. However, developing the models is a manual process that can take many years. These approaches have largely been developed independently. We present Linker, an efficient and automated data-driven method that analyzes molecular interactomes. Linker combines teleporting random walks and k-shortest path computations to discover connections from a set of source proteins to a set of target proteins. We demonstrate the efficacy of Linker through two applications: proposing extensions to an existing model of cell cycle regulation in budding yeast and automated reconstruction of human signaling pathways. Linker achieves superior precision and recall compared to state-of-the-art algorithms from the literature.Ph. D.
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Ralston, Jonathon Carey. "Identification of a class of nonlinear systems in the non-Gaussian input case." Thesis, Queensland University of Technology, 1996. https://eprints.qut.edu.au/36000/2/36000_Digitised_Thesis.pdf.
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Chanda, Michael, Julee DiPlacido, John Dougherty, Richard Egan, John Kelly, Trent Kingery, Daniel Liston, et al. "Proposed functional architecture and associated benefits analysis of a common ground control station for Unmanned Aircraft Systems." Thesis, Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/6949.
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Approved for public release; distribution is unlimitedThe proliferation of Unmanned Aerial Systems (UASs) and lack of mandated standards has led to unique Unmanned Aerial Vehicle (UAV) and Ground Control Station (GCS) designs. A former Under Secretary of Defense for Acquisition, Technology, and Logistics, stated in an Acquisition Decision Memorandum (ADM) that UAS GCS commonality could reduce manpower, procurement, sustainment and life cycle costs. While the ADM provided an impetus for commonality, it did not define a path. This project defines a common GCS functional architecture that provides the first steps on the path to UAS commonality. Stakeholder documentation was analyzed to identify areas of greatest concern and to examine previous efforts in this domain. Then, a tailored systems engineering process was employed to develop a new set of requirements which includes a common Air Vehicle Operator (AVO) Human-Machine Interface. These requirements enabled the creation of an innovative functional architecture for a common GCS concept. The utilization of this architecture has multiple operational, logistical, and financial benefits. This project quantified AVO training cost benefits and found that implementation of the common GCS architecture in accordance with the derived requirements will benefit the Department of Defense through reduced Operations and Support costs and increased operational capability.
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Ogris, Christoph. "Global functional association network inference and crosstalk analysis for pathway annotation." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-146703.
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Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. Small-scale experiments deliver high quality data but lack coverage whereas high-throughput techniques cover thousands of interactions but can be error-prone. Unfortunately all of these approaches can only focus on one type of interaction at the time. This makes experimental mapping of the genome-wide network a cost and time intensive procedure. However, to overcome these problems, different computational approaches have been suggested that integrate multiple data sets and/or different evidence types. This widens the stringent definition of an interaction and introduces a more general term - functional association. FunCoup is a database for genome-wide functional association networks of Homo sapiens and 16 model organisms. FunCoup distinguishes between five different functional associations: co-membership in a protein complex, physical interaction, participation in the same signaling cascade, participation in the same metabolic process and for prokaryotic species, co-occurrence in the same operon. For each class, FunCoup applies naive Bayesian integration of ten different evidence types of data, to predict novel interactions. It further uses orthologs to transfer interaction evidence between species. This considerably increases coverage, and allows inference of comprehensive networks even for not well studied organisms. BinoX is a novel method for pathway analysis and determining the relation between gene sets, using functional association networks. Traditionally, pathway annotation has been done using gene overlap only, but these methods only get a small part of the whole picture. Placing the gene sets in context of a network provides additional evidence for pathway analysis, revealing a global picture based on the whole genome. PathwAX is a web server based on the BinoX algorithm. A user can input a gene set and get online network crosstalk based pathway annotation. PathwAX uses the FunCoup networks and 280 pre-defined pathways. Most runs take just a few seconds and the results are summarized in an interactive chart the user can manipulate to gain further insights of the gene set's pathway associations.At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 2: Manuscript.
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Cubuk, Cankut. "Modeling Functional Modules Using Statistical and Machine Learning Methods." Doctoral thesis, Universitat Politècnica de València, 2020. http://hdl.handle.net/10251/156175.
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[ES] La comprensión de los aspectos de la funcionalidad de las células que cuentan para los mecanismos de las enfermedades es el mayor reto de la medicina personalizada. A pesar de la disponibilidad creciente de los datos de genómica y transcriptómica, sigue existiendo una notable brecha entre la detección de las perturbaciones en la expresión de genes y la comprensión de su contribución en los mecanismos moleculares que últimamente tienen relación importante con el fenotipo estudiado. A lo largo de la última década, distintos modelos computacionales y matemáticos se han propuesto para el análisis de las rutas. Sin embargo, estos modelos no toman en cuenta los mecanismos dinámicos de las rutas como la estructura y las interacciones entre genes y proteínas. En esta tesis doctoral, presento dos modelos matemáticos ligeramente distintos, para integrar los datos transcriptómicos masivos de humano con un conocimiento previo de de las rutas de señalización y metabólicas para estimar las actividades mecánicas que están detrás de esas rutas (MPAs). Las MPAs son variables continuas con valores de nivel individual que pueden ser usadas con los modelos de aprendizaje de máquinas y métodos estadísticos para determinar los biomarcadores que podemos usar para los diagnósticos tempranos y la clasificación de subtipos de enfermedades, además de poder sugerir las dianas terapéuticas potenciales para las intervenciones individualizadas.
El objetivo global es desarrollar nuevos y avanzados enfoques de la biología de sistemas para proponer unas hipótesis funcionales que nos ayuden a entender e interpretar los mecanismos complejos de las enfermedades. Estos mecanismos son cruciales para mejorar los tratamientos personalizados y predecir los resultados clínicos. En primer lugar, contribuí al desarrollo de un método que está diseñado para extraer las subrutas elementales desde la ruta de señalización con sus actividades estimadas. Posteriormente, este algoritmo se ha adaptado a los módulos metabólicos y se ha implementado como una herramienta web. Finalmente , el método ha revelado un panorama metabólico para una lista completa de diferentes tipos de cánceres. En este estudio, analicé el perfil metabólico de 25 tipos de cáncer distintos y se validó el método usando varios enfoques computacionales y experimentales. Cada método desarrollado en esta tesis ha sido enfrentado a otros métodos similares existentes, evaluados por sus sensibilidades y especificidades, experimentalmente validados cuando fue posible y usados para predecir resultados clínicos de varios tipos de cánceres. La investigación descrita en esta tesis y los resultados obtenidos fueron publicados en distintas revistas arbitradas que están relacionadas con el cáncer y biología de sistemas, y también en los periódicos nacionales.[CA] La comprensió dels aspectes de la funcionalitat de les cèl·lules que compten per als mecanismes de les malalties és el major repte de la medicina personalitzada. Malgrat la disponibilitat creixent de les dades de genòmica i transcriptómica, continua existint una notable bretxa entre la detecció de les pertorbacions en l'expressió de gens i la comprensió de la seua contribució en els mecanismes moleculars que últimament tenen relació important amb el fenotip estudiat. Al llarg de l'última dècada, diferents models computacionals i matemàtics s'han proposat per a l'anàlisi de les rutes. No obstant això, aquests models no tenen en compte els mecanismes dinàmics de les rutes com l'estructura i les interaccions entre gens i proteïnes. En aquesta tesi doctoral, presente dos models matemàtics lleugerament diferents, per a integrar les dades transcriptómicos massius d'humà amb un coneixement previ de de les rutes de senyalització i metabòliques per a estimar les activitats mecàniques que estan darrere d'aqueixes rutes (MPAs). Les MPAs són variables contínues amb valors de nivell individual que poden ser usades amb els models d'aprenentatge de màquines i mètodes estadístics per a determinar els biomarcadores que podem usar per als diagnòstics primerencs i la classificació de subtipus de malalties, a més de poder suggerir les dianes terapèutiques potencials per a les intervencions individualitzades. L'objectiu global és desenvolupar nous i avançats enfocaments de la biologia de sistemes per a proposar unes hipòtesis funcionals que ens ajuden a entendre i interpretar els mecanismes complexos de les malalties. Aquests mecanismes són crucials per a millorar els tractaments personalitzats i predir els resultats clínics. En primer lloc, vaig contribuir al desenvolupament d'un mètode que està dissenyat per a extraure les subrutas elementals des de la ruta de senyalització amb les seues activitats estimades. Posteriorment, aquest algorisme s'ha adaptat als mòduls metabòlics i s'ha implementat com una eina web. Finalment, el mètode ha revelat un panorama metabòlic per a una llista completa de diferents tipus de càncers. En aquest estudi, vaig analitzar el perfil metabòlic de 25 tipus de càncer diferents i es va validar el mètode usant diversos enfocaments computacionals i experimentals. Cada mètode desenvolupat en aquesta tesi ha sigut enfrontat a altres mètodes similars existents, avaluats per les seues sensibilitats i especificitats, experimentalment validats quan va ser possible i usats per a predir resultats clínics de diversos tipus de càncers. La investigació descrita en aquesta tesi i els resultats obtinguts van ser publicats en diferents revistes arbitrades que estan relacionades amb el càncer i biologia de sistemes, i també en els periòdics nacionals.
[EN] Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is the main challenge for precision medicine. In spite of the increasing availability of genomic and transcriptomic data, there is still a gap between the detection of perturbations in gene expression and the understanding of their contribution to the molecular mechanisms that ultimately account for the phenotype studied. Over the last decade, different computational and mathematical models have been proposed for pathway analysis. However, they are not taking into account the dynamic mechanisms contained by pathways as represented in their layout and the interactions between genes and proteins. In this thesis, I present two slightly different mathematical models to integrate human transcriptomic data with prior knowledge of signalling and metabolic pathways to estimate the Mechanistic Pathway Activities (MPAs). MPAs are continuous and individual level values that can be used with machine learning and statistical methods to determine biomarkers for the early diagnosis and subtype classification of the diseases, and also to suggest potential therapeutic targets for individualized therapeutic interventions. The overall objective is, developing new and advanced systems biology approaches to propose functional hypotheses that help us to understand and interpret the complex mechanism of the diseases. These mechanisms are crucial for robust personalized drug treatments and predict clinical outcomes. First, I contributed to the development of a method which is designed to extract elementary sub-pathways from a signalling pathway and to estimate their activity. Second, this algorithm adapted to metabolic modules and it is implemented as a webtool. Third, the method used to reveal a pan-cancer metabolic landscape. In this study, I analyzed the metabolic module profile of 25 different cancer types and the method is also validated using different computational and experimental approaches. Each method developed in this thesis was benchmarked against the existing similar methods, evaluated for their sensitivity and specificity, experimentally validated when it is possible and used to predict clinical outcomes of different cancer types. The research described in this thesis and the results obtained were published in different systems biology and cancer-related peer-reviewed journals and also in national newspapers.
Cubuk, C. (2020). Modeling Functional Modules Using Statistical and Machine Learning Methods [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/156175
TESIS
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Madison, Guy. "Functional modelling of the human timing mechanism." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5012-1/.
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Zhou, Mingyan. "Structural and functional analysis of a novel organic cation/monoamine transporter PMAT in the SLC29 family /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7979.
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Hölzer, Stefanie. "Functional analysis of type III secretion systems in Salmonella enterica = Funktionelle Analyse von Typ-III-Sekretionssystemen in Salmonella enterica." kostenfrei, 2010. http://d-nb.info/1001858735/34.
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Kantanantha, Nantachai. "Crop decision planning under yield and price uncertainties." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/24676.
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Thesis (Ph.D.)--Industrial and Systems Engineering, Georgia Institute of Technology, 2007.Committee Co-Chair: Griffin, Paul; Committee Co-Chair: Serban, Nicoleta; Committee Member: Liang, Steven; Committee Member: Sharp, Gunter; Committee Member: Tsui, Kwok-Leung
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Sullivan, Lisa, Lennard Cannon, Ronel Reyes, Kitan Bae, James Colgary, Nick Minerowicz, Chris Leong, et al. "Rapid Response Command and Control (R2C2): a systems engineering analysis of scaleable communications for Regional Combatant Commanders." Monterey, California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/7267.
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Includes supplemental material.Disaster relief operations, such as the 2005 Tsunami and Hurricane Katrina, and wartime operations, such as Operation Enduring Freedom and Operation Iraqi Freedom, have identified the need for a standardized command and control system interoperable among Joint, Coalition, and Interagency entities. The Systems Engineering Analysis Cohort 9 (SEA-9) Rapid Response Command and Control (R2C2) integrated project team completed a systems engineering (SE) process to address the military’s command and control capability gap. During the process, the R2C2 team conducted mission analysis, generated requirements, developed and modeled architectures, and analyzed and compared current operational systems versus the team’s R2C2 system. The R2C2 system provided a reachback capability to the Regional Combatant Commander’s (RCC) headquarters, a local communications network for situational assessments, and Internet access for civilian counterparts participating in Humanitarian Assistance/Disaster Relief operations. Because the team designed the R2C2 system to be modular, analysis concluded that the R2C2 system was the preferred method to provide the RCC with the required flexibility and scalability to deliver a rapidly deployable command and control capability to perform the range of military operations.
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Flöttmann, Max [Verfasser], Edda [Akademischer Betreuer] Klipp, Andreas [Akademischer Betreuer] Herrmann, and Ralf [Akademischer Betreuer] Mrowka. "Functional analysis of High-Throughput data for dynamic modeling in eukaryotic systems / Max Flöttmann. Gutachter: Edda Klipp ; Andreas Herrmann ; Ralf Mrowka." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://d-nb.info/1041679793/34.
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Ziv, Nicolas. "Enrichment of functional analysis for the construction sector by the integration of systems engineering and constructibility : application to the multifunctional metro." Thesis, Paris Est, 2018. http://www.theses.fr/2018PESC1065/document.
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L’objectif de la thèse est d’enrichir l’Analyse Fonctionnelle, une méthode de conception orientée sur la définition des fonctions d’un produit, pour le développement d’ouvrages complexes dans le domaine de la construction. Pour cela les concepts et pratiques de deux corpus méthodologiques sont adaptés et intégrés dans l’Analyse Fonctionnelle : l’Ingénierie Système et la Constructibilité. Cette méthode enrichie est appliquée sur un concept innovant de métro multifonctionnel qui consiste à utiliser un système unique pour répondre à plusieurs besoins de la ville : non seulement transporter des passagers mais aussi de l’eau, des déchets, de l’électricité, de la chaleur, de l’information, des marchandises et bien d’autres selon les particularités de chaque projet. Dans l’introduction après avoir brièvement décrit les enjeux rencontrés dans le domaine de la construction, qui justifient le besoin de nouvelles méthodes, nous soulignons que l’Analyse Fonctionnelle a essentiellement été utilisée dans d’autres domaines que celui de la construction pour faire face aux mêmes problèmes. En revanche, son application au domaine de la construction est limitée du fait de la non prise en compte des particularités de ce secteur : le besoin auquel répondent les systèmes dans ce domaine sont d’adapter l’espace pour que s’y réalise des activités humaines, mais aussi que chaque projet est unique. L’unicité de chaque projet nous a amené à prendre en compte la constructibilité, soit les contraintes liées au développement de l’ouvrage, à différentes étapes de l’Analyse Fonctionnelle. L’Analyse Fonctionnelle est aussi mal adaptée pour le développement de systèmes complexes, ainsi, les concepts et outils de l’ingénierie Système, dont l’objectif est la maitrise des systèmes complexes, sont intégrés à l’Analyse Fonctionnelle (V&V, SysML). La première partie de la thèse consiste en un état de l’art des trois méthodes étudiées : l’Analyse Fonctionnelle, l’Ingénierie Système et la Constructibilité. Dans cette partie les blocages et des adaptations nécessaires sont identifiés. Dans une deuxième partie, la méthode d’Analyse Fonctionnelle enrichie par la Constructibilité et l’Ingénierie Système est présentée. Le concept de Constructibilité notamment est étendu à la prise en compte non seulement des contraintes liées aux activités de réalisation mais aussi aux contraintes de conception et de planification/programmation (soit l’ensemble du système pour faire). L’Ingénierie Système pour sa part est adaptée en prenant en compte les caractéristiques spatiales des systèmes, composantes essentielles dans la construction. Deux outils ont été développés pendant la thèse permettant d’implémenter la méthode : un outil de modélisation des exigences basé sur le langage de modélisation SysML qui permet de lier les exigences avec des modèles BIM (Building Information Modeling) améliorant ainsi leur traçabilité et la facilitation de leur vérification, et la matrice de constructibilité qui permet d’analyser la constructibilité d’un système en prenant en compte l’ensemble des contraintes liées à son développement. Troisièmement, la méthode d’Analyse Fonctionnelle enrichie est appliquée sur 2 cas d’études liés au métro multifonctionnel : l’application de ce concept sur les études de la 5ème ligne de Lyon vers Alaï et l’intégration d’un réseau de fibre optique alimentant l’île de France dans la ligne 16 du projet du Grand Paris. En conclusion des pistes de recherche pour le futur sont proposées : d’autres méthodologies de conception existent avec des objectifs différents (innovation pour la théorie C-K) ou des nouveaux concepts (System of Systems). Ou comment mesurer et quantifier les critères de constructibilité ? Comment appliquer ces méthodes dans différents contextes législatifs et contractuels ? Sont autant de question qui méritent de nouvelles recherches ultérieuresObjectives of the thesis is to enrich Functional Analysis, a design method oriented on the definition of functions, by the integration of two methodological corpuses: Constructability and Systems Engineering in order to adapt it to complex construction products. The enriched method is used and applied on an innovative concept: the multifunctional metro. This new concept consists in the integration of new functions in a metro system: not only transport people but also energy, information, wastes, merchandises, water etc. in order to answer to several city needs with a unique infrastructure. In the introduction, after having describe challenges faced by the construction industry, we highlight that Functional Analysis has been used extensively in other industries to face similar issues. However, its application in the construction industry is limited due to particularities of the construction industry: each project is unique, construction projects are complex and that needs construction projects answer consists in adapting space in order to carry human or related activities. The identification of such particularities have led on one hand, to the consideration of constructability concepts and principles in Functional Analysis to better integrate development constraints of each project in the product development. On the other hand, to the consideration of Systems Engineering, a methodological corpus which objective is to manage complexity of projects. Firstly, Functional Analysis, Constructability and Systems Engineering corpuses are presented and issues are identified in these three methods either to adapt them to complex construction projects for their integration. Constructability notably, is improved with the integration of constraints from Design and Planning phases and a proposition is presented to shift from Constructability to Constructibility. Systems Engineering for its part is adapted by the integration of spatial characteristics of systems. A SysML tool (Systems Modeling Language) has been developed and linked with a BIM modeling tool to improve the capacity to model and verify requirements related to construction systems. The Constructibility matrix, a tool to ease the implementation of constructibility has also been developed.Secondly, Functional Analysis enriched by methodological inputs and tools related to the construction industry is applied. Case studies concern two different phases (planning and design) in two different projects where multifunctionnality concepts have been investigated: the 5th metro line of Lyon where the evaluation of the integration of new functions in the metro line have been studied. And the line 16 of the Greater Paris Project where the integration of a broadband network was the opportunity to study the integration of a new function more in detail (transport information). In conclusion we shall suggest some ways forward by outlining avenues for further researches: how to measure constructibility criteria at different systemic levels is a challenge on which we give some ways to follow. The application and adaptation of Systems Engineering to the construction industry remains to be better investigated and we give some further research indications, particularly on the integration with BIM (Building Information Modeling) methods. We also present how the use of MBSE (Model-Based Systems Engineering) techniques and Data Science could lead to the automation of some design activities which could enrich Functional Analysis methods. Insights on the organization of the profession and contractual issues are proposed and would require more researches to enable implementation of the presented methodology in projects
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Pedott, Alexandre Homsi. "Análise de dados funcionais aplicada ao estudo de repetitividade e reprodutividade : ANOVA das distâncias." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/24726.
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Esta dissertação apresenta um método adaptado do estudo de repetitividade e reprodutibilidade para analisar a capacidade e o desempenho de sistemas de medição, no contexto da análise de dados funcionais. Dado funcional é a variável de resposta dada por uma coleção de dados que formam um perfil ou uma curva. O método adaptado contribui para o avanço do estado da arte sobre a análise de sistemas de medição. O método proposto é uma alternativa ao uso de métodos tradicionais de análise, que usados de forma equivocada, podem deteriorar a qualidade dos produtos monitorados através de variáveis de resposta funcionais. O método proposto envolve a adaptação de testes de hipótese e da análise de variância de um e dois fatores usados em comparações de populações, na avaliação de sistemas de medições. A proposta de adaptação foi baseada na utilização de distâncias entre curvas. Foi usada a Distância de Hausdorff como uma medida de proximidade entre as curvas. A adaptação proposta à análise de variância foi composta de três abordagens. Os métodos adaptados foram aplicados a um estudo simulado de repetitividade e reprodutibilidade. O estudo foi estruturado para analisar cenários em que o sistema de medição foi aprovado e reprovado. O método proposto foi denominado de ANOVA das Distâncias.This work presents a method to analyze a measurement system's performance in a functional data analysis context, based on repeatability and reproducibility studies. Functional data are a collection of data points organized as a profile or curve. The proposed method contributes to the state of the art on measurement system analysis. The method is an alternative to traditional methods often used mistakenly, leading to deterioration in the quality of products monitored through functional responses. In the proposed method we adapt hypothesis tests and one-way and two-way ANOVA to be used in measurement system analysis. The method is grounded on the use of distances between curves. For that matter the Hausdorff distance was chosen as a measure of proximity between curves. Three ANOVA approaches were proposed and applied in a simulated repeatability and reproducibility study. The study was structured to analyze scenarios in which the measurement system was approved or rejected. The proposed method was named ANOVA of the distances.
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Boyanova, Desislava Veselinova Verfasser], and Thomas [Akademischer Betreuer] [Dandekar. "Systems biological analysis of the platelet proteome and applications of functional module search in proteome networks / Desislava Veselinova Boyanova. Betreuer: Thomas Dandekar." Würzburg : Universität Würzburg, 2013. http://d-nb.info/1102820911/34.
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Boyanova, Desislava Veselinova [Verfasser], and Thomas [Akademischer Betreuer] Dandekar. "Systems biological analysis of the platelet proteome and applications of functional module search in proteome networks / Desislava Veselinova Boyanova. Betreuer: Thomas Dandekar." Würzburg : Universität Würzburg, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72165.
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Fan-Osuala, Onochie. "Essays on Crowdfunding: Exploring the Funding and Post-funding Phases and Outcomes." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6834.
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In the recent years, crowdfunding (a phenomenon where individuals collectively contribute money to back different goals and projects through the internet) has been gaining a lot of attention especially for its socio-economic impact. This dissertation explores this phenomenon in three distinct but related essays. The first essay explores the nature and dynamics of backers’ contributions and uses the insights generated to develop a forecasting model that can predict crowdfunding campaign outcomes. The second essay investigates how creators’ crowdfunding campaign design decisions impact their funding and post-funding outcomes. Interestingly, the essay highlights that certain crowdfunding campaign design decisions have differential effects on both funding and post-funding phases and this has implications for creators, backers, and crowdfunding platform owners. Finally, the third essay investigates whether creators’ post-funding relations-building efforts with backers matter and how such relations-building efforts might impact the performance of their subsequent crowdfunding campaign. In general, this dissertation not only increases our understanding of the crowdfunding phenomenon across the funding and post-funding phases, it also provides insights and tools that can help stakeholders maximize the benefits accruable to them when they engage in crowdfunding.