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Vasic, N., M. Dudeck, A. Knein, K. Rasche, R. Mentel, J. Streb, B. Connemann, Z. Sosic-Vasic, and S. Otte. "Fragebogen zur therapeutischen Beziehung in der Forensik (FTBF): Ergebnisse einer Pilotstudie." Fortschritte der Neurologie · Psychiatrie 83, no. 12 (December 29, 2015): 686–93. http://dx.doi.org/10.1055/s-0041-110391.
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Armstrong, Stephanie, Melissa Prah, Jennifer Connelly, Max Krucoff, Wade Mueller, and Kathleen Schmainda. "NIMG-44. DSC-MRI FRACTIONAL TUMOR BURDEN VOLUME PREDICTS OVERALL SURVIVAL IN UNMETHYLATED NEWLY DIAGNOSED HIGH GRADE GLIOMA." Neuro-Oncology 24, Supplement_7 (November 1, 2022): vii173. http://dx.doi.org/10.1093/neuonc/noac209.662.
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Abstract OBJECTIVE Image maps of Fractional Tumor Burden (FTB), derived from dynamic susceptibility contrast (DSC) perfusion MRI, provide clinically meaningful information for glioma treatment management. The goal of this study was to determine if presurgical FTB is predictive of overall survival (OS) in high-grade glioma (HGG) classified according to WHO 2016 criteria. METHODS Standardized relative cerebral blood volume (sRCBV) maps were created and co-registered with T1+C images using Horos (Version 4.0.0) and Imaging Biometrics software (Version 21.05) (Elm Grove, WI). Enhancing tumor volumes were determined from calibrated pre/post T1 difference (dT1) maps. Tissue-validated sRCBV thresholds were used to create FTB class maps within enhancing lesion with red regions (sRCBV > 1.556) indicating a high probability of vascular tumor, blue regions (sRCBV< 1.0) indicating avascular (non-tumor) tissue and yellow representing tissue with a lower probability of vascular tumor. FTB volume fractions (FTBv) for all vascular tumor (sRCBV >1.0) or the most vascular tumor (sRCBV > 1.566) were determined. Subjects were separated by MGMT methylation status. GraphPad Prism statistical software (Version 9.3.1) was used for Kaplan Meier survival analysis at 12 and 24 months with patients stratified by median FTBv. RESULTS Forty-one subjects (23 males, 18 females) with a median age of 59.45 years were included. Median 12-month and overall survival of unmethylated groups stratified by FTBv (rCBV > 1.0) of 8.33cc was 10.69 and 15.35 months (p=.0453; p=.0317). Unmethylated subjects stratified with FTBv (rCBV > 1.566) of 7.13cc had a median survival of 10.69 and 15.20 with short- and long-term survival distinguished at 12 months (p=0.0033), 24 months (p=0.0002) and overall (p=0.0002). No significant difference in survival was found between the methylated subgroups with FTBv (rCBV > 1.0) or FTBv (rCBV > 1.566) stratified analyses. CONCLUSION These results demonstrate that pre-surgical FTBv is predictive of OS in newly diagnosed unmethylated high-grade glioma.
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Sena, Luciano Silva, Gleyson Vieira dos Santos, Tatiana Saraiva Torres, Antônio De Sousa Júnior, Aurino De Araújo Rego Neto, José Lindenberg Rocha Sarmento, and Daniel Biagiotti. "Genetic parameters for carcass traits and body size of meat sheep." Semina: Ciências Agrárias 37, no. 4Supl1 (September 2, 2016): 2477. http://dx.doi.org/10.5433/1679-0359.2016v37n4supl1p2477.
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The present study aimed to estimate variance components and heritability coefficients (h2) in Santa Inês sheep by single- and two-trait analyses for the traits loin eye area (LEA), length (LEL) and maximum depth (LED), in the longissimus dorsi muscle, subcutaneous fat thickness (SFT), fat thickness over the biceps femoris muscle (FTBF), croup height (CH), thoracic circumference (TC), thoracic depth (TD), body length (BL), and adult live weight (ALW). The restricted maximum likelihood (REML) was used to estimate variance components in an animal model. In both types of analyses, we estimated moderate heritability for all traits, with the exception of SFT, CH, TC, BL, and ALW (all of which yielded low h2 estimates). In two-trait analysis for body size, only TD yielded a lower h2 estimate, when compared to single-trait analysis. On the other hand, CH, TC, and BL yielded higher h2 estimates. Most estimates for variance components and h2 in two-trait analysis were higher than those in single-trait analysis. This finding suggests the possibility of a moderate response to selection for improvement in the carcass of meat sheep using the specific carcass traits evaluated (except SFT), highlighting LEA. The fat thickness over the biceps femoris muscle showed higher potential for response to direct selection for fat deposition than SFT. Thoracic depth showed higher potential for response to direct selection for body size than the other morphometric measurements. In the present study, adult live weight was not an effective criterion for direct selection.
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Sutanto, Jemmy, D. H. Kang, J. H. Yoon, K. S. Oh, Michael Oh, R. Lanzone, and R. Huemoeller. "CoC (Chip on Chip) or FtoF (Face to Face) - PossumTM Technology for 3D MEMS and ASIC eliminating the need of TSV or Wire Bonding." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2013, DPC (January 1, 2013): 000916–36. http://dx.doi.org/10.4071/2013dpc-tp33.
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This paper describes the ongoing 3 years research and development at Amkor Technology on CoC (Chip on Chip)/FtF (Face to Face) – PossumTM technology. This technology has showed a lot of interests from the microelectronics customers/industries because of its various advantages, which include a) providing smaller form factor (SFF) to the final package, b) more functionalities (dies) can be incorporated/assembled in one package, c) improving the electrical performance - including lower parasitic resistance, lower power, and higher frequency bandwidth, and d) Opportunity for lower cost 3D system integration. Unlike other 3D Packaging technology (e.g. using TSV (Through Silicon Vias)) that requires some works in the front stream (wafer foundry) level, needs new capitals for machines/equipments, and needs modified assembly lines; CoC/FtF technology uses the existing flip Chip Attach (C/A) or TC (Thermal Compression) equipment/machine to perform the assembly joint between the two dies, which are named as the mother (larger) die and the daughter (smaller) die. Furthermore, the cost to assemble CoC/FtF is relatively inexpensive while the applications are very wide and endless, which include the 3D integration of MEMS and ASIC. The current MEMS packaging and test cost contributes about 35 to 45% to the overall MEMS unit cost. WLC (Wafer Level Capping) with wire bonding have been widely used for mass production for accelerometer (e.g. ADI and Motorola), gyroscope (e.g. Bosch and Invensense), and oscillator /timer (e.g. Discera). The WLC produce drawbacks of a large form factor and the increase in the capacitive and electrical resistances. Currently, the industries have been developing a new approach of 3D WLP (Wafer Level Packaging) by using a) TSV MEMS cap with wire bonding (e.g. Discera), b) TSV MAME cap with solder bump (e.g. Samsung, IMEC, and VTI), and c) TSV MEMS wafer/die with cap (e.g. Silex Microsystems). The needs of TSVs in the 3D WLP will add the packaging cost and reduce the design flexibility is pre-TSV wafer is used. “Amkor CoC/FtoF – PossumTM” is an alternative technology for 3D integration of MEMS and ASIC. CoC/FtoF – PossumTM does not require TSV or wire bonding; Miniaturizing form factor of 1.5 mm x 1.5 mm x 0.95 mm (including the package) of MEMS and ASIC can be achieved by using CoC/FtoF – PossumTM while Discera's design of 3D WLP requires substrate size > 2 mm x 2 mm. CoC/FtoF – PossumTM will likely produce packaging cost which is lower than WLC or 3D WLP – TSV at the same time the customer is benefited from smaller FF and reduced electrical/parasitic resistance. CoC/FtoF – PossumTM can be applied to any substrates including FCBGA and laminate. This technology also can be applied to package multiple MEMS microsensors, together with ASIC, microcontroller, and wireless RF to realize the 3D system integration.
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Ayoade, Oladotun, Vian Ahmed, and David Baldry. "Interoperability optimisation for shared equity housing model development and FTB homeownership in the UK." International Journal of Housing Markets and Analysis 12, no. 4 (August 5, 2019): 558–80. http://dx.doi.org/10.1108/ijhma-12-2017-0110.
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Purpose This paper aims to assess financial interoperability implications associated with first-time buyers (FTB) in housing development and the role of the community land trust shared equity housing model (CLT SEHM). Design/methodology/approach The interoperability optimisation process adopted by this study involved triangulated findings from the literature, semi-structured interviews and questionnaire surveys. The text analysis of interview responses was actualised with Nvivo 9.0. This process informed the validation of themes through a questionnaire survey (purposive sampling), of which findings were subsequently analysed with statistical methods including binary logistic regression to validate interoperability rational and implications. Findings The study identified positive financial interoperability outcomes for a successful synergy between the CLT SEHM and FTBs. From the analysis, there were sustainable results for average income multiple and property transfer/resale value for the CLT SEHM compared to conventional models. However, for the most at risk FTB groups, recommendations included increased concessions for CLT SEHM developments to incentivise bespoke rent purchase hybrid schemes. Originality/value This research provided a good starting point for achieving an improved level of efficiency necessary for the introduction of emerging/renewed alternative housing models into mainstream operational capabilities in housing and local development policies.
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Blaise, Didier, Reza Tabrizi, Anne-Gaelle Le Corroller-Soriano, Mauricette Michallet, Jacques-Olivier Bay, Mohamad Mohty, Catherine Faucher, et al. "Prospective Randomized Comparison of Reduced Intensity (FLU-BU-ATG) and Non-Myeloablative (FLU-TBI) Conditioning for Genoidentical Allo-SCT: a Clinical and economical Multicenter Itac Study." Blood 114, no. 22 (November 20, 2009): 193. http://dx.doi.org/10.1182/blood.v114.22.193.193.
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Abstract Abstract 193 No definitive data exist defining the optimal myeloablative and/or immunosuppressive association of Reduced Intensity Conditioning (RIC) for allo-SCT. In this perspective, we report the first prospective comparison between 2 widely used conditioning regimens based on reduced intensity or non-myeloablative approaches. Pts were randomized between FBA (Study A) (Fludarabine (30mg/m2/5 days)+Oral Busulfan (4 mg/kg/d over 2 days)+Thymoglobuline (2.5 mg/kg/1day)) (Post graft immunosuppression (IS): CSA) and FTBI (Study B) (Fludarabine (25mg/m2/day over 3 days)+2 Gy TBI) (Post Graft IS: CSA+MMF). Primary endpoint was one-year overall survival (OS). Inclusion criteria were: hematological malignancies, pts non eligible for myeloablative allo SCT, age between 18 and 65, suitable HLA identical sibling, written informed consent. 139 pts were randomized and treated between 2003 and 2008 (Group FBA: N=69; group FTBI: N=70) at 4 transplant centers. The 2 groups were comparable in term of pts characteristics; Median age 54 (21–65); Male gender: 65%; Diagnosis: acute leukemia 18%; NHL 23%; MM 39% others 20%; Disease status: only 32% of the 139 pts were in CR while 68% had measurable disease (PR and stable disease=60%; refractory disease: 8%). Graft failure was documented in 4 pts (6%) in FTBI group. Cumulative incidences (CI) of grade >= 2 aGVHD and cGVHD were respectively: 37% (Group FBA 51%; Group FTBI 26%; p=.003) and 77% (Group FBA 79%; Group FTBI 76%: p=NS). At 1 year, PFS differed (Group FBA 0.68 [0.56 – 0.78]; Group FTBI 0.51 [0.39 – 0.62]; p=0.048) while OS was similar (Group FBA 0.75 [0.63 – 0.84]; Group FTBI 0.74 [0.62 – 0.83]; p=NS). With a median follow-up of 39 months (3–71), 72 pts were alive (Group FBA: 35; Group FTBI: 37: p=NS) with a 5 year OS probability estimate of 0.45 [0.31– 0.57] and 0.49 [0.35– 0.61] for groups FBA and FTBI respectively (p=NS). 53 pts were progression free with a 5 year PFS probability estimate of 0.35 [0.22– 0.48] for group FBA ,and 0.23 [0.10– 0.38] for Group FTBI (p=NS). Median PFS were 26.3 (IC95%:13.6 – 47.3) and 13.1 (IC95% : 7.4 – 25.6) months (mths) in groups FBA and FTBI respectively. More relapses/progressions occurred in group FTBI (p=.005) with a 5 year relapse/progression cumulative incidence (CI) of 0.28 [0.16– 0.40] for group FBA and 0.50 [0.39– 0.60] for Group FTBI. Three pts died from secondary cancers (Group FBA: 1; Group FTBI: 2) and 38 from transplant related causes with a 5 year TRM CI of 0.37 [0.25– 0.49] for group FBA and 0.24 [0.14– 0.34] for Group FTBI (p=0.199). QOL was assessed over a 1-year period with the EORTC QLQ-C30 questionnaire. FBA regimen had a stronger negative impact on patients' QOL during the treatment administration which resolved 80 days after the SCT. Detailed economic analysis was included in the clinical trial. Preliminary evaluation of medical direct costs (conditioning regimen, transfusions, hospitalisations and anti-infectious drugs consumption) demonstrated a crude advantage for the FTBI group (66,711€ vs 42,080€ for the FBA and FTBI groups respectively, p<0.001). The cost-effectiveness ratio using PFS as endpoint was 22,392 € per year of life free of relapse gained using FBA conditioning regimen when compared to FTBI. In conclusion, this study establishes that, these 2 regimens produce similar 1 year OS. However, FBA is associated with better 1 year PFS and socially acceptable cost-effectiveness ratio but worse early QOL. FBA is also associated with better long term disease control, whereas FTBI tends to produce lower TRM and higher rejection rates. At 5 years, both OS and PFS appear to be similar in this population of rather old patients with advanced hematological malignancies. Cost-effectiveness analysis using OS as effectiveness criterion and including the cost evaluation of relapse treatment is ongoing. Overall, these results contribute to clarify some previously unanswered issues. Clinical data might help designing individual and optimal strategies for each candidate patient, based on factors that predict the probability of relapse and TRM while economical data may help hospitals to tailor their transplant program, depending on the patient population that they care for. Disclosures: Blaise: Gemzyme: Consultancy, Research Funding; Amgen: Consultancy, Honoraria, Research Funding; Pierre-Fabre: Consultancy, Research Funding. Off Label Use: Busulfan, Thymoglobulin, .
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Wilcox, D. L., and L. L. Howell. "Fully compliant tensural bistable micromechanisms (FTBM)." Journal of Microelectromechanical Systems 14, no. 6 (December 2005): 1223–35. http://dx.doi.org/10.1109/jmems.2005.859089.
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Guo, Zicong, Lijuan Wang, Ruge Cao, and Ju Qiu. "Effect of Frozen Treatment on the Sensory and Functional Quality of Extruded Fresh Noodles Made from Whole Tartary Buckwheat." Foods 11, no. 24 (December 9, 2022): 3989. http://dx.doi.org/10.3390/foods11243989.
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Extruded noodles made from whole Tartary buckwheat are widely known as healthy staple foods, while the treatment of fresh noodles after extrusion is crucial. The difference in sensory and functional quality between frozen noodles (FTBN) and hot air-dried noodles (DTBN) was investigated in this study. The results showed a shorter optimum cooking time (FTBN of 7 min vs. DTBN of 17 min), higher hardness (8656.99 g vs. 5502.98 g), and less cooking loss (5.85% vs. 21.88%) of noodles treated by freezing rather than hot air drying, which corresponded to better sensory quality (an overall acceptance of 7.90 points vs. 5.20 points). These effects on FTBN were attributed to its higher ratio of bound water than DTBN based on the Low-Field Nuclear Magnetic Resonance results and more pores of internal structure in noodles based on the Scanning Electron Microscopy results. The uniform water distribution in FTBN promoted a higher recrystallization (relative crystallinity of FTBN 26.47% vs. DTBN 16.48%) and retrogradation (degree of retrogradation of FTBN 34.67% vs. DTBN 26.98%) of starch than DTBN, strengthening the stability of starch gel after noodle extrusion. FTBN also avoided the loss of flavonoids and retained better antioxidant capacity than DTBN. Therefore, frozen treatment is feasible to maintain the same quality as freshly extruded noodles made from whole Tartary buckwheat. It displays significant commercial potential for gluten-free noodle production to maximize the health benefit of the whole grain, as well as economic benefits since it also meets the sensory quality requirements of consumers.
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Aldyab, M., S. Najjar, J. V. Rand, and H. Lee. "Tumor budding (TB) in Colorectal Cancer (CRC), The Best Slide To Count On!" American Journal of Clinical Pathology 154, Supplement_1 (October 2020): S150—S151. http://dx.doi.org/10.1093/ajcp/aqaa161.329.
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Abstract Introduction/Objective TB is a strong prognosticator in CRC. The international TB consensus conference (ITBCC, 2016) proposed a “hot spot” approach for TB grading. We aimed to identify the characteristics of sections with the highest TB grade utilizing ITBCC’s method. Methods Resected CRC cases, excluding treated cases, were retrieved. All tumor sections were examined. Section TB grade(sTB) was noted. The highest sTB was deemed the final TB grade(fTB) of each case. The following categories were assessed: 1) maximum T stage; 2) presence of benign mucosa; 3) presence of a precursor lesion; 4) highest tumor volume; 5) presence of lymphovascular invasion(LVI). In cases where a given category was demonstrated in >1 section, the section with the highest sTB was used. High risk features (HFR) included T4, <12 lymph nodes, positive margin, high grade tumor, perineural invasion and LVI. Pearson’s correlation was performed to compare two groups using a p-value of <0.05. Results 147 cases were examined. fTB was 1=25.2%, 2=40.8% and 3=34%. 63 tumors involved the left colon and 62 had nodal disease. Of 119 cases with known MMR status 44 were MMR deficient. sTB was uniform across the categories in 101(68.7%) and uneven in 46(32.3%) cases. 12(24.5%) of 49 stage II CRC without HRF showed uneven sTB, with 2 showing 2-tier discrepancy (sTB1, fTB3). sTB was highest for category 3 (94.1%, P<.001), followed by category 2 (91.8%, P<.001), and lowest for category 1 (82.3%, P<.001), which remained true after subgrouping by MMR status and tumor location. Conclusion While about 70% of cases showed uniform TB grading across categories, choosing the slide(s) with a precursor lesion or benign mucosa increases the probability of correctly grading TB. Given the management implication, it may be prudent to scan all tumor slides in stage II CRC without HRF to avoid under-grading of TB.
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Wu, Xiaoli, Zhimin Zhou, Yuehui Wang, and Jingze Li. "Syntheses of Silver Nanowires Ink and Printable Flexible Transparent Conductive Film: A Review." Coatings 10, no. 9 (September 7, 2020): 865. http://dx.doi.org/10.3390/coatings10090865.
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Nowadays, flexible transparent conductive film (FTCF) is one of the important components of many flexible electronic devices. Due to comprehensive performances on optoelectronics, FTCF based on silver nanowires (AgNWs) networks have received great attention and are expected to be a new generation of transparent conductive film materials. Due to its simple process, printed electronic technology is now an important technology for the rapid production of low-cost and high-quality flexible electronic devices. AgNWs-based FTCF fabricated by using printed electronic technology is considered to be the most promising process. Here, the preparation and performance of AgNW ink are introduced. The current printing technologies are described, including gravure printing, screen printing and inkjet printing. In addition, the latest methods to improve the conductivity, adhesion, and stability of AgNWs-based FTCF are introduced. Finally, the applications of AgNWs-based FTCF in solar cells, transparent film heaters, optoelectronic devices, touch panel, and sensors are introduced in detail. Therefore, combining various printing technologies with AgNWs ink may provide more opportunities for the development of flexible electronic devices in the future.
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Dharmaratnam, Arathi, Raj Kumar, Basheer Saidmuhammed Valaparambil, Neeraj Sood, Pravata Kumar Pradhan, Sweta Das, and T. Raja Swaminathan. "Establishment and characterization of fantail goldfish fin (FtGF) cell line from goldfish, Carassius auratus for in vitro propagation of Cyprinid herpes virus-2 (CyHV-2)." PeerJ 8 (July 14, 2020): e9373. http://dx.doi.org/10.7717/peerj.9373.
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Background Herpesviral hematopoietic necrosis disease, caused by cyprinid herpesvirus-2 (CyHV-2), is responsible for massive mortalities in the aquaculture of goldfish, Carassius auratus. Permissive cell lines for the isolation and propagation of CyHV-2 have been established from various goldfish tissues by sacrificing the fish. Here, we report the development of a cell line, FtGF (Fantail Goldfish Fin), from caudal fin of goldfish using non-lethal sampling. We also describe a simple protocol for successful establishment and characterization of a permissive cell line through explant method and continuous propagation of CyHV-2 with high viral titer using this cell line. Methods Caudal fin tissue samples were collected from goldfish without killing the fish. Cell culture of goldfish caudal fin cells was carried out using Leibovitz’s L-15 (L-15) medium containing 20% FBS and 1X concentration of antibiotic antimycotic solution, incubated at 28 °C. Cells were characterized and origin of the cells was confirmed by sequencing fragments of the 16S rRNA and COI genes. CyHV-2 was grown in the FtGF cells and passaged continuously 20 times. The infectivity of the CyHV-2 isolated using FtGF cells was confirmed by experimental infection of naïve goldfish. Results The cell line has been passaged up to 56 times in L-15 with 10% FBS. Karyotyping of FtGF cells at 30th, 40th and 56th passage indicated that modal chromosome number was 2n = 104. Species authentication of FtGF was performed by sequencing of the 16S rRNA and COI genes. The cell line was used for continuous propagation of CyHV-2 over 20 passages with high viral titer of 107.8±0.26 TCID50/mL. Following inoculation of CyHV-2 positive tissue homogenate, FtGF cells showed cytopathic effect by 2nd day post-inoculation (dpi) and complete destruction of cells was observed by the 10th dpi. An experimental infection of naïve goldfish using supernatant from infected FtGF cells caused 100% mortality and CyHV-2 infection in the challenged fish was confirmed by the amplification of DNA polymerase gene, histopathology and transmission electron microscopy. These findings provide confirmation that the FtGF cell line is highly permissive to the propagation of CyHV-2.
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Galarneau, L., J. F. Paré, D. Allard, D. Hamel, L. Levesque, J. D. Tugwood, S. Green, and L. Bélanger. "The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family." Molecular and Cellular Biology 16, no. 7 (July 1996): 3853–65. http://dx.doi.org/10.1128/mcb.16.7.3853.
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The alpha1-fetoprotein (AFP) gene is located between the albumin and alpha-albumin genes and is activated by transcription factor FTF (fetoprotein transcription factor), presumed to transduce early developmental signals to the albumin gene cluster. We have identified FTF as an orphan nuclear receptor of the Drosophila FTZ-F1 family. FTF recognizes the DNA sequence 5'-TCAAGGTCA-3', the canonical recognition motif for FTZ-F1 receptors. cDNA sequence homologies indicate that rat FTF is the ortholog of mouse LRH-1 and Xenopus xFF1rA. Rodent FTF is encoded by a single-copy gene, related to the gene encoding steroidogenic factor 1 (SF-1). The 5.2-kb FTF transcript is translated from several in-frame initiator codons into FTF isoforms (54 to 64 kDa) which appear to bind DNA as monomers, with no need for a specific ligand, similar KdS (approximately equal 3 x 10(-10) M), and similar transcriptional effects. FTF activates the AFP promoter without the use of an amino-terminal activation domain; carboxy-terminus-truncated FTF exerts strong dominant negative effects. In the AFP promoter, FTF recruits an accessory trans-activator which imparts glucocorticoid reactivity upon the AFP gene. FTF binding sites are found in the promoters of other liver-expressed genes, some encoding liver transcription factors; FTF, liver alpha1-antitrypsin promoter factor LFB2, and HNF-3beta promoter factor UF2-H3beta are probably the same factor. FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages, similar to SF-1 in steroidogenic tissues. HepG2 hepatoma cells seem to express a mutated form of FTF.
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De Groote, Hugo, Bernard Munyua, Djibril Traore, John R. N. Taylor, Mario Ferruzzi, Cheikh Ndiaye, Isiguzoro O. Onyeoziri, and Bruce R. Hamaker. "Measuring consumer acceptance of instant fortified millet products using affective tests and auctions in Dakar, Senegal." International Food and Agribusiness Management Review 24, no. 3 (April 13, 2021): 499–522. http://dx.doi.org/10.22434/ifamr2020.0068.
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Small-scale affordable extruders create new opportunities for small enterprise food processors to manufacture nutritionally enhanced products. Still, consumer interest in these products needs to be assessed first. Affective tests with 296 consumers in Dakar, Senegal, evaluated five pearl millet flours: (a) conventional, compared to four instant-porridge flour products; (b) sifted; (c) wholegrain; (d) sifted with premix; (e) wholegrain with micronutrient premix and food-to-food fortified (FtFF). Willingness-to-pay (WTP) was elicited through experimental auctions under two treatments: firstly without information, then with information. Consumers liked FtFF (taste, aroma, appearance) but were indifferent to instant. They did not appreciate wholegrain flour (appearance) or premix (appearance, aroma and taste). Without information, consumers showed no differences in WTP. With information, consumers paid premiums for FtFF (27-30%) (both treatments), and premix (17%), instant (9%), and wholegrain (-10%) (one treatment). Costs of instant, wholegrain and premix products were lower than consumers’ WTP, indicating potential profits, but not those of FtFF. There is a market for instant cereals in Senegal. Consumers require product information in order to compromise on some attributes to benefit from instant, fortified and wholegrain pearl millet products. Manufacture would be cost-effective, but FtFF costs need to be reduced.
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Serra, Sandro. "Using outcrop data and analog models to aid seismic interpretation in fold and thrust belts." Interpretation 6, no. 4 (November 1, 2018): SM51—SM61. http://dx.doi.org/10.1190/int-2018-0014.1.
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Seismic data in fold and thrust belts (FTBs), especially in onshore areas, are often difficult to interpret due to poor imaging of complex structures. Outcrops, either in the same area as the seismic or in FTBs with similar stratigraphy, provide direct and essentially unfiltered views of structures that can form in this structural style. In addition, physical and mathematical analog models can provide insights on the development of compressional structures and the parameters that most strongly influence their shape. The task of seismic interpretation in FTBs can be aided substantially by using well-exposed outcrops and analog models of compressional structures as templates.
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Kwon, Hyuk-Cheol, Hyejin Sohn, Do-Hyun Kim, Chang-Hee Jeong, Dong-Wook Kim, and Sung-Gu Han. "Effects of Flutriafol Fungicide on the Lipid Accumulation in Human Liver Cells and Rat Liver." Foods 10, no. 6 (June 10, 2021): 1346. http://dx.doi.org/10.3390/foods10061346.
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Flutriafol (FTF) is a triazole fungicide that can cause liver toxicity through the ingestion of its residues in food and water. However, little is known about the liver toxicity of FTF, particularly nonalcoholic fatty liver disease (NAFLD) in humans. Therefore, the purpose of this study was to investigate whether FTF induces NAFLD in human liver cells and animal liver. HepG2 cells and Sprague Dawley (SD) rats were treated with FTF at doses of 0–640 µM for 24 h and 0–150 mg/kg bw/day for 28 days, respectively. FTF (80, 160, and 320 µM) treatment to cells induced lipid accumulation. FTF (80 and 160 µM)-treated cells had higher levels of cytochrome P450 enzymes and reactive oxygen species and increased mitochondrial membrane potential loss than the control. FTF also increased the mRNA levels of antioxidant enzymes through oxidative stress and nuclear factor erythroid 2-related factor 2 pathways in HepG2 cells. However, a higher level of FTF (320 µM) induced apoptosis. The treatment of SD rats with FTF (2.5–150 mg/kg bw/day) induced fatty infiltration in the liver by impairing liver metabolism and inducing apoptosis. Therefore, our data suggest that human exposure to FTF residues may be a risk factor for liver diseases, such as NAFLD.
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A. Hatem, Wadhah, Hafadh I. Naji, and Zainab A. Abd Alkreem. "Using of Advanced Communication Technology in the Construction Projects During the Implementation Stage." Diyala Journal of Engineering Sciences 11, no. 2 (June 1, 2018): 14–23. http://dx.doi.org/10.24237/djes.2018.11202.
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Iraq is a wide country in the area and construction projects have been distributed in many places, therefore this research studies the ability to use advanced communication tools such as computer-mediated communication instead of traditional communication (Face To Face). Revit application which based on BIM technology have been used , this application helped in exchange design information between designer and site engineer for in making decisions , solving problems ,reduce wasted time and reduce the expenses that occur as a result of the use of FTF communication .The results concluded from this research are that communication quantity in FTF was more than in CMC where Total Number of Words (TNOW) were in FTF 303 while in CMC 246 , The percentage of Number of Work Related Words said in CMC is higher than in FTF, it was 87% in CMC and 81% in FTF of the (TNOW) , it is indicating that communication in CMC more productive than communication in FTF, in addition to that the working time in CMC were (262 seconds every 5-minutes) slightly higher than in FTF were (252 seconds every 5-minutes), this explains that CMC was slightly more productive than FTF . Wasted time for FTF consistently higher than wasted time in CMC ,where the averages of wasted time spent for every 5 minutes were 32 second in FTF and 21 in CMC ,this is due to that FTF was easier than CMC in terms of social speech. To identify degree collaboration between users in two methods by the total number of exchanges in CMC was higher than in FTF because most of the persons were having more interaction when using CMC.
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Shang, Quan, Luxing Pan, Monica Saumoy, John Y. L. Chiang, G. Stephen Tint, Gerald Salen, and Guorong Xu. "An overlapping binding site in the CYP7A1 promoter allows activation of FXR to override the stimulation by LXRα." American Journal of Physiology-Gastrointestinal and Liver Physiology 293, no. 4 (October 2007): G817—G823. http://dx.doi.org/10.1152/ajpgi.00209.2007.
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The aim of this study was to explore why in rabbits activation of farnesoid X receptor (FXR) is dominant over activated liver X receptor-α (LXRα) in the regulation of CYP7A1. We cloned the rabbit CYP7A1 promoter and found a fetoprotein transcription factor (FTF) binding element embedded within the LXRα binding site (LXRE). Gel shift assays demonstrated that FTF competes with LXRα for binding to LXRE. Short heterodimer partner (SHP) enhances the competitive ability of FTF. Studies in HepG2 cells showed that SHP combined with FTF had more powerful effect to offset the stimulation of CYP7A1 by LXRα. Gel shift and chromatin immunoprecipitation assays demonstrated that SHP with FTF diminished LXRα binding to the CYP7A1 promoter. In vivo studies in rabbits fed cholesterol for 10 days showed that hepatic expression of SHP but not FTF rose and LXRα-bound LXRE decreased. We propose that the SHP/FTF heterodimer occupies LXRE via the embedded FTF binding element and blocks LXRα from recruiting to LXRE. Therefore, activation of FXR, which upregulates SHP expression, will eliminate the stimulatory effect of LXRα on the CYP7A1 promoter because increased levels of SHP combined with FTF diminish the recruitment of LXRα to CYP7A1 promoter.
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Gómez, J., and B. Torrecillas. "Strongly graded left FTF rings." Publicacions Matemàtiques 36 (July 1, 1992): 609–23. http://dx.doi.org/10.5565/publmat_362a92_21.
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Gómez-Torrecillas, J., and B. Torrecillas. "FTF Rings and Frobenius Extensions." Journal of Algebra 248, no. 1 (February 2002): 1–14. http://dx.doi.org/10.1006/jabr.2001.9027.
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Son, Changgil, Wonyeol An, Geonhee Lee, Inho Jeong, Yong-Gu Lee, and Kangmin Chon. "Adsorption Characteristics of Phosphate Ions by Pristine, CaCl2 and FeCl3-Activated Biochars Originated from Tangerine Peels." Separations 8, no. 3 (March 13, 2021): 32. http://dx.doi.org/10.3390/separations8030032.
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This study has evaluated the removal efficiencies of phosphate ions (PO43−) using pristine (TB) and chemical-activated tangerine peel biochars. The adsorption kinetics and isotherm presented that the enhanced physicochemical properties of TB surface through the chemical activation with CaCl2 (CTB) and FeCl3 (FTB) were helpful in the adsorption capacities of PO43− (equilibrium adsorption capacity: FTB (1.655 mg g−1) > CTB (0.354 mg g−1) > TB (0.104 mg g−1)). The adsorption kinetics results revealed that PO43− removal by TB, CTB, and FTB was well fitted with the pseudo-second-order model (R2 = 0.999) than the pseudo-first-order model (R2 ≥ 0.929). The adsorption isotherm models showed that the Freundlich equation was suitable for PO43− removal by TB (R2 = 0.975) and CTB (R2 = 0.955). In contrast, the Langmuir equation was proper for PO43− removal by FTB (R2 = 0.987). The PO43− removal efficiency of CTB and FTB decreased with the ionic strength increased due to the compression of the electrical double layer on the CTB and FTB surfaces. Besides, the PO43− adsorptions by TB, CTB, and FTB were spontaneous endothermic reactions. These findings demonstrated FTB was the most promising method for removing PO43− in waters.
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Gilbert, Stéphane, Luc Galarneau, Alain Lamontagne, Sylvie Roy, and Luc Bélanger. "The Hepatitis B Virus Core Promoter Is Strongly Activated by the Liver Nuclear Receptor Fetoprotein Transcription Factor or by Ectopically Expressed Steroidogenic Factor 1." Journal of Virology 74, no. 11 (June 1, 2000): 5032–39. http://dx.doi.org/10.1128/jvi.74.11.5032-5039.2000.
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ABSTRACT Orphan nuclear receptor fetoprotein transcription factor (FTF) was previously identified as a specific regulator of the α1-fetoprotein gene during early liver development and in response to hormonal signals (L. Galarneau, J.-F. Paré, D. Allard, D. Hamel, L. Lévesque, J. D. Tugwood, S. Green, and L. Bélanger, Mol. Cell. Biol. 16:3853–3865, 1996). Here we report a functional analysis of FTF interactions with the hepatitis B virus (HBV) nucleocapsid promoter. DNA-protein-binding assays show that the HBV core promoter contains two high-affinity FTF-binding sites and a third, lower-affinity site shared with other receptors. Transfections in HepG2, Hep3B, and PLC/PRF/5 hepatoma cells using chloramphenicol acetyltransferase reporter genes with the nucleocapsid promoter linked or not linked to enhancer I indicate that FTF is a potent activator of the HBV core promoter, more efficient than HNF4α, HNF3α, HNF3β, or C/EBPα. Steroidogenic factor 1, a close FTF homolog which binds to the same DNA motif and is expressed ectopically in HepG2 cells, seems to be an even stronger inducer than FTF. Point mutations of the FTF-binding sites indicate direct FTF activatory effects on the core promoter and the use of both high-affinity sites for productive interaction between the core promoter and enhancer I. Coexpression assays further indicate that FTF and HNF4α are the most efficient partners for coactivation of the pregenomic core promoter, which may largely account for the hepatic tropism and the early amplification of HBV infection. Carboxy terminus-truncated FTF behaves as a dominant negative mutant to compete all three FTF sites and strongly deactivate core promoter interactions with enhancer I; this suggests possible new ways to interfere with HBV infection.
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Muñoz-Mahamud, Ernesto, Jenaro Ángel Fernández-Valencia, Andreu Combalia, Laura Morata, and Álex Soriano. "Fluorescent tetracycline bone labeling as an intraoperative tool to debride necrotic bone during septic hip revision: a preliminary case series." Journal of Bone and Joint Infection 6, no. 4 (January 27, 2021): 85–90. http://dx.doi.org/10.5194/jbji-6-85-2021.
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Abstract. A plausible cause of persistent infection after septic hip revision may be the presence of nonviable osteomyelitic bone. Since surgical excision of these necrotic fragments is often challenging, the use of fluorescent tetracycline bone labeling (FTBL) as an intraoperative tool may pose an additional assessment aid to provide a visual index of surgical debridement. Methods: We present a single-center study performed in a university hospital from January 2018 to June 2020, in which all consecutive cases of chronic hip periprosthetic joint infection (PJI) undergoing revision using FTBL were retrospectively reviewed. In all cases, the patient was under treatment with tetracyclines at the moment of the revision surgery. During the surgery, all bone failing to fluoresce was considered nonviable and thus removed and sent for both culture and histology. Results: We include three cases in which the FTBL technique was used. In all cases, the histopathological examinations of the nonfluorescent removed bone were consistent with chronic osteomyelitis. Conclusion: The intraoperative use of FTBL successfully aided the surgeon to detect the presence of nonviable bone in all the presented cases of chronic prosthetic hip infection.
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Ning, Fanggang, Huihao Jiang, Jiaming Qiu, and Lifang Wang. "Different Depths May Not Determine the Fluid Resuscitation Volume in Early-stage Management of Severe Burns: A Model-comparison Retrospective Analysis of Fluid Volume Determining Factors." Journal of Burn Care & Research 43, no. 2 (October 15, 2021): 412–18. http://dx.doi.org/10.1093/jbcr/irab185.
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Abstract Large-volume fluid resuscitation remains irreplaceable in the early-stage management of severe burns. We aimed to explore the relationship between fluid volume and other indicators. Data of severe burn patients with successful resuscitation in the early stage was collected. Correlation and linear regression analyses were performed. Multiple linear regression models, related goodness-of-fit assessment (adjusted R-square and Akaike Information Criterion), scatter plots, and paired t-test for two models, and a likelihood ratio test were performed. 96 patients were included. The median of total burn area (TBA) was 70%TBSA, with full thickness burn area (FTBA)/TBA of 0.4, a resuscitation volume of 1.93 mL/kg/%TBSA. Among volume-correlated indicators, two linear regression models were established (Model 1: TBA × weight and tracheotomy; and Model 2: FTBA × weight, partial thickness burn area (PTBA) × weight, and tracheotomy). For these models, close values of Akaike Information Criterion, adjusted R-squares, outliers of the prediction range, and the result of paired t-test, all suggest similarity between two models estimations, while the likelihood ratio test for coefficients of FTBA × weight and PTBA × weight showed a statistical difference. Inhalational injury and decompression surgery only correlated with volume, while Tracheotomy, TBA × weight, FTBA × weight, and PTBA × weight correlated with and were accepted in linear models of volume. Although FTBA and PTBA differed statistically, there may be no need to distinguish them when estimating the resuscitation volume requirements in this patient set. Further study about different depths fluid should be conducted.
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Fu, Chen-Zhao, Wen-Rong Si, Lei Quan, and Jian Yang. "Numerical Study of Heat Transfer in Trefoil Buried Cable with Fluidized Thermal Backfill and Laying Parameter Optimization." Mathematical Problems in Engineering 2019 (February 25, 2019): 1–13. http://dx.doi.org/10.1155/2019/4741871.
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Trefoil buried cable is one of the important cable arrangements for the underground transmission line, and its heat transfer performance is relatively poor. By filling with fluidized thermal backfill material (FTB) around trefoil buried cables, the heat transfer would be efficiently enhanced, while the filling cost should also be considered. In the present study, the heat transfer process in the FTB trefoil buried cables is numerically studied, where the cable core loss and eddy current loss in the cable were coupled for the simulation. The heat transfer performances and ampacities for trefoil buried cables with different back fill materials were analysed and compared with each other. Then, the laying parameters for the parabolic-type FTB trefoil buried cables were optimized with the radial basis function neural network (RBNN) and genetic algorithm (GA). Firstly, it is found that, with FTB material, the maximum temperature in the cable core is obviously reduced, and the cable ampacity is greatly improved as compared with the cables buried around natural soil (NS). Secondly, when compared with flat-type FTB model, the heat transfer rate in the cable with parabolic-type FTB laying method would be slightly reduced, while the FTB amount used for the buried cables is greatly reduced. Finally, as for parabolic-type FTB trefoil buried cables, with proper design of geometric parameters (s1 = 0.290 m, s2 = 0.302 m, and l = 0.3 m with I = 1300 A) for the FTB laying cross section, the overall performance for the cable was optimized.
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Warmund, Michele R., and Denny Schrock. "Clientele Perceptions of Master Gardener Training Delivered via Interactive Television versus Face to Face." HortTechnology 9, no. 1 (January 1999): 116–21. http://dx.doi.org/10.21273/horttech.9.1.116.
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Master Gardener training was delivered via interactive television (IT) or face to face (FTF) in Missouri in 1997. IT and FTF participants were surveyed on their acceptance of the Master Gardener training method and their perceptions of program quality and technology to evaluate the newly developed multiple site IT training. Demographic characteristics were also recorded to determine if IT format attracted a different clientele than that of FTF training. Those who participated in IT training generally had more years of education than those in the FTF training and lived in suburban rather than rural areas. IT participants missed fewer training sessions than FTF participants. However, IT participants rated the slide quality, sound, and overall training lower than the FTF group. Some problems associated with IT training identified by the participants are correctable, which should improve future acceptance of this technology.
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Peterson, Ken A., Daniel S. Krueger, and Charles E. Sandoval. "Selected Applications and Processing for Low Temperature Cofired Ceramic." International Symposium on Microelectronics 2010, no. 1 (January 1, 2010): 000248–53. http://dx.doi.org/10.4071/isom-2010-tp3-paper2.
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Low Temperature Cofired Ceramic technology has proven itself in microelectronics, microsystems (including microfluidic systems), sensors, radio frequency (RF) features, and various other non-electronic applications. We will discuss selected applications and the processing associated with those applications. We will then focus on our recent work in the area of electromagnetic isolation (EMI) shielding using full tape thickness features (FTTF) and sidewall metallization. The FTTF is very effective in applications with −150 dB isolation requirements, but presents obvious processing difficulties in full-scale fabrication. The FTTF forms a single continuous solid wall around the volume to be shielded by using sequential punching and feature-filling. Sidewall metallization provides another method for shielding. We discuss the material incompatibilities and manufacturing considerations that need to be addressed for such structures and show preliminary implementations.
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Malekigorji, Maryam. "The Effect of Continued Team Randomization on Student’s Perception and Performance in a Blended Team-Based Teaching Approach." Education Sciences 9, no. 2 (May 10, 2019): 102. http://dx.doi.org/10.3390/educsci9020102.
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The purpose of this study is to investigate how constant changes in team allocation within a modified flipped team-based learning (FTBL) study can affect student’s perception of a course (gathered by an online questionnaire) and academic performance. This teaching strategy is a team-based learning (TBL) approach combined with flipped classroom learning methodology, in which BSc students studying pharmaceutical science/biotechnology courses in a UK satellite campus in China preview online lectures and apply their knowledge in different in-class activities. The students are randomly assigned into teams in each session. The project was run across the full academic year (sixteen sessions). Students’ perceptions regarding modified FTBL were statistically analyzed, and their academic performance was compared with previous results obtained by the initial FTBL study. Although students initially showed reluctance to leave their ‘comfort zone’—the main limitation of this study—our findings show that learners perceived benefits to the adoption of continued random allocation, which resulted in the removal of limitations from their social clustering and eventual accustomization to this learning approach. Modified FTBL assisted students in enhancing their team-work skills, improving their academic performance, developing their reflective capabilities, improving their rapport building skills, learning and academic performance. Learners also believed that this learning strategy creates critical incidents that can simulate their future work environment, as they might be expected to work in unfamiliar situations. Therefore, the present study indicated strong support for the modified FTBL method, which was seen to work exceptionally well despite some minor problems that students experienced working in a team with different teammates in every session.
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Martin-Khan, Melinda G., Helen Edwards, Richard Wootton, Paul Varghese, Kwang Lim, Peteris Darzins, Lucy Dakin, and Leonard C. Gray. "Web-based (online) comprehensive geriatric assessment is more time efficient, and as reliable, as reading patient medical records and conducting traditional in person consultations." Journal of Telemedicine and Telecare 22, no. 8 (October 30, 2016): 478–82. http://dx.doi.org/10.1177/1357633x16674088.
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The aim of this study was to report the time taken by geriatricians to reach triage decisions using an online assessment format compared with face-to-face (FTF) assessment. Patients ( N = 166) were randomly allocated to two groups: online and FTF assessments (OF group); and dual FTF assessments (FF group). Case preparation was conducted by trained nurse assessors using a web-enabled clinical decision support system. Geriatricians allocated to perform an ‘online’ assessment had access to this information only. Geriatricians allocated FTF assessments reviewed this data, as well as the paper-based medical file and then consulted directly with the patient and attending staff. Data were collected in relation to time taken to complete OL assessments, compared with FTF assessments. A complete OL consultation averages 10 minutes, and a FTF consultation almost 26 minutes. In FTF consultations, less time is spent using the OL material when the geriatrician is aware that they will have access to the patient chart and need time to speak with the patient. The less time taken using the OL approach did not significantly alter the triage decisions made by the geriatricians.
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van Hijum, S. A. F. T., G. H. van Geel-Schutten, H. Rahaoui, M. J. E. C. van der Maarel, and L. Dijkhuizen. "Characterization of a Novel Fructosyltransferase from Lactobacillus reuteri That Synthesizes High-Molecular-Weight Inulin and Inulin Oligosaccharides." Applied and Environmental Microbiology 68, no. 9 (September 2002): 4390–98. http://dx.doi.org/10.1128/aem.68.9.4390-4398.2002.
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ABSTRACT Fructosyltransferase (FTF) enzymes produce fructose polymers (fructans) from sucrose. Here, we report the isolation and characterization of an FTF-encoding gene from Lactobacillus reuteri strain 121. A C-terminally truncated version of the ftf gene was successfully expressed in Escherichia coli. When incubated with sucrose, the purified recombinant FTF enzyme produced large amounts of fructo-oligosaccharides (FOS) with β-(2→1)-linked fructosyl units, plus a high-molecular-weight fructan polymer (>107) with β-(2→1) linkages (an inulin). FOS, but not inulin, was found in supernatants of L. reuteri strain 121 cultures grown on medium containing sucrose. Bacterial inulin production has been reported for only Streptococcus mutans strains. FOS production has been reported for a few bacterial strains. This paper reports the first-time isolation and molecular characterization of (i) a Lactobacillus ftf gene, (ii) an inulosucrase associated with a generally regarded as safe bacterium, (iii) an FTF enzyme synthesizing both a high molecular weight inulin and FOS, and (iv) an FTF protein containing a cell wall-anchoring LPXTG motif. The biological relevance and potential health benefits of an inulosucrase associated with an L. reuteri strain remain to be established.
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Katz, Shayna. "Rapport in the Foreign Language Classroom: From Face-to-Face to Online in Times of Pandemic." Íkala 26, no. 3 (September 10, 2021): 485–511. http://dx.doi.org/10.17533/udea.ikala/v26n3a02.
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As shown in previous studies, positive teacher and student rapport increases motivation and performance in foreign language learning. This study investigated the impact of three forms of interaction on the development of teacher-student and student-student relationships in a Spanish as a Foreign Language classroom that transitioned from face-to-face (FtoF) to online due to the emergence of the covid- 19 pandemic. These forms of interaction were positive comments, corrective feedback, and personal thematic discourse. The participants were students from six different beginner-level Spanish courses at a university in Hawai’i. Because of covid restrictions, half of the semester was conducted FtoF and half online. Data were collected through a three-part questionnaire with open and closed-ended questions which explored the impact of the online and FtoF setting and forms of interaction on rapport. The results reveal the importance of corrective feedback and positive comments on the development of positive teacher-student rapport, and of positive comments and personal thematic discourse on student-student rapport. The study suggests the need to bring qualities from the FtoF classroom to online, such as a sense of a more personal experience, ability to connect, ease in asking questions, receiving feedback, and greater interaction.
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Katz, Shayna. "Rapport in the Foreign Language Classroom: From Face-to-Face to Online in Times of Pandemic." Íkala 26, no. 3 (September 10, 2021): 485–511. http://dx.doi.org/10.17533/udea.ikala.v26n3a02.
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As shown in previous studies, positive teacher and student rapport increases motivation and performance in foreign language learning. This study investigated the impact of three forms of interaction on the development of teacher-student and student-student relationships in a Spanish as a Foreign Language classroom that transitioned from face-to-face (FtoF) to online due to the emergence of the covid- 19 pandemic. These forms of interaction were positive comments, corrective feedback, and personal thematic discourse. The participants were students from six different beginner-level Spanish courses at a university in Hawai’i. Because of covid restrictions, half of the semester was conducted FtoF and half online. Data were collected through a three-part questionnaire with open and closed-ended questions which explored the impact of the online and FtoF setting and forms of interaction on rapport. The results reveal the importance of corrective feedback and positive comments on the development of positive teacher-student rapport, and of positive comments and personal thematic discourse on student-student rapport. The study suggests the need to bring qualities from the FtoF classroom to online, such as a sense of a more personal experience, ability to connect, ease in asking questions, receiving feedback, and greater interaction.
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Katz, Shayna. "Rapport in the Foreign Language Classroom: From Face-to-Face to Online in Times of Pandemic." Íkala 26, no. 3 (September 10, 2021): 485–511. http://dx.doi.org/10.17533/udea.ikala.v26n3a02.
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As shown in previous studies, positive teacher and student rapport increases motivation and performance in foreign language learning. This study investigated the impact of three forms of interaction on the development of teacher-student and student-student relationships in a Spanish as a Foreign Language classroom that transitioned from face-to-face (FtoF) to online due to the emergence of the covid- 19 pandemic. These forms of interaction were positive comments, corrective feedback, and personal thematic discourse. The participants were students from six different beginner-level Spanish courses at a university in Hawai’i. Because of covid restrictions, half of the semester was conducted FtoF and half online. Data were collected through a three-part questionnaire with open and closed-ended questions which explored the impact of the online and FtoF setting and forms of interaction on rapport. The results reveal the importance of corrective feedback and positive comments on the development of positive teacher-student rapport, and of positive comments and personal thematic discourse on student-student rapport. The study suggests the need to bring qualities from the FtoF classroom to online, such as a sense of a more personal experience, ability to connect, ease in asking questions, receiving feedback, and greater interaction.
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Wang, Ningxin, David J. Roaché, and Kimberly B. Pusateri. "Associations Between Parents’ and Young Adults’ Face-to-Face and Technologically Mediated Communication Competence: The Role of Family Communication Patterns." Communication Research 46, no. 8 (January 17, 2018): 1171–96. http://dx.doi.org/10.1177/0093650217750972.
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This study examined associations between parents’ and young adults’ communication competence in the contexts of face-to-face (FtF) and technologically mediated communication (TMC). We investigated the role of family communication patterns in parental socialization of communication competence. In our investigation, we focused on two distinct aspects of communication competence: effectiveness and appropriateness. Analyzing self-report data of 104 parent-child dyads, we found that parents’ self-reported FtF communication appropriateness was directly associated with children’s self-reported FtF and TMC appropriateness. Children’s reports of conversation orientation were positively associated with their self-reported FtF and TMC effectiveness. Additionally, parents’ reports of conformity orientation were positively linked to children’s self-reported FtF communication appropriateness. These findings suggest that parental influences may manifest through different mechanisms for children’s communication effectiveness and appropriateness. Further, parents and family communication play important roles in children’s development of communication competence not only in FtF interactions, but also in TMC interactions.
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Smeraglia, Luca, Nathan Looser, Olivier Fabbri, Flavien Choulet, Marcel Guillong, and Stefano M. Bernasconi. "U–Pb dating of middle Eocene–Pliocene multiple tectonic pulses in the Alpine foreland." Solid Earth 12, no. 11 (November 9, 2021): 2539–51. http://dx.doi.org/10.5194/se-12-2539-2021.
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Abstract. Foreland fold-and-thrust belts (FTBs) record long-lived tectono-sedimentary activity, from passive margin sedimentation, flexuring, and further evolution into wedge accretion ahead of an advancing orogen. Therefore, dating fault activity is fundamental for plate movement reconstruction, resource exploration, and earthquake hazard assessment. Here, we report U–Pb ages of syn-tectonic calcite mineralizations from four thrusts and three tear faults sampled at the regional scale across the Jura fold-and-thrust belt in the northwestern Alpine foreland (eastern France). Three regional tectonic phases are recognized in the middle Eocene–Pliocene interval: (1) pre-orogenic faulting at 48.4±1.5 and 44.7±2.6 Ma associated with the far-field effect of the Alpine or Pyrenean compression, (2) syn-orogenic thrusting at 11.4±1.1, 10.6±0.5, 9.7±1.4, 9.6±0.3, and 7.5±1.1 Ma associated with the formation of the Jura fold-and-thrust belt with possible in-sequence thrust propagation, and (3) syn-orogenic tear faulting at 10.5±0.4, 9.1±6.5, 5.7±4.7, and at 4.8±1.7 Ma including the reactivation of a pre-orogenic fault at 3.9±2.9 Ma. Previously unknown faulting events at 48.4±1.5 and 44.7±2.6 Ma predate the reported late Eocene age for tectonic activity onset in the Alpine foreland by ∼10 Myr. In addition, we date the previously inferred reactivation of pre-orogenic strike-slip faults as tear faults during Jura imbrication. The U–Pb ages document a minimal time frame for the evolution of the Jura FTB wedge by possible in-sequence thrust imbrication above the low-friction basal decollement consisting of evaporites.
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G’Sell, David, Herbert Phelan, Sydney Smith, Lacy Virgadamo, Mario Rivera-Barbosa, Kathryn Mai, and Jeffrey E. Carter. "578 Failure to Follow-Up: Implementation of a Program to Reduce Risk and Engage Patients." Journal of Burn Care & Research 42, Supplement_1 (April 1, 2021): S140—S141. http://dx.doi.org/10.1093/jbcr/irab032.228.
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Abstract Introduction Establishing a patient-physician relationship creates a duty to meet the standard of care for inpatients and outpatients. Growth in burn ambulatory care, workforce changes, and the digital age of healthcare communications have broadened the definition of the patient-physician relationship and increased ambulatory medical liability especially when patients fail to follow-up (FTF). To mitigate this risk, many professional liability insurers have advised physician practices to implement processes to ensure appropriate follow-up and communication. Our study reviewed a multidisciplinary quality and performance improvement initiative to reduce risk from FTF with a goal to improve patient engagement. Methods In response to notification by our medical professional liability insurer, a multidisciplinary team of burn specialists reviewed, designed, and implemented a FTF risk reduction program at an ABA-verified burn center. Burn surgeons, physician assistants (PA), nurses, schedulers, and administrative assistants contributed to the development of the FTF protocol. Patients were discharged with follow-up date and time from inpatients stays or at the conclusion of outpatient encounters. If a patient had a FTF event, three attempts were made to contact the patient starting with the scheduler, followed by the nurse, and finally the PA or MD. Each attempt was documented in the EMR. Compliance with the FTF protocol was monitored twice monthly as a component of the burn quality and performance improvement program. Outpatient encounters were abstracted from the EMR into three categories: completions, cancellations, and FTF over a 4-month period prior to implementation and 4-month period post implementation. Results Our analysis included over 2,678 outpatient physician/PA encounters. Prior to implementation patients were intermittently contacted with no consistent processes or documentation in the EMR. Staff compliance with the FTF protocol improved from 83% the first month after implementation to 100% by the fourth month. Interestingly, the failure to cancellation rate remained stable while the failure to follow-up rate declined from 15% prior to implementation to 13% post implementation. Patients failing to follow-up commonly stated that they forgot or had transportation challenges. Conclusions FTF protocols are essential to engage patients and reduce ambulatory professional liability. Patients will continue to face FTF challenges with language barriers, transportation issues, natural disasters, and even the pandemic. This study was not designed to reduce cancellations or FTF as it is reactionary. Additional work is needed to reduce all causes of FTF and to improve outpatient engagement.
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Bistre, M., R. Eitan, O. Linkovsky, I. Barash, A. Juven-Wetzler, G. Katz, Y. Kohn, et al. "A comparative study reveals a similar validity of telepsychiatry and face-to-face psychiatric assessment in emergency room setting." European Psychiatry 64, S1 (April 2021): S348—S349. http://dx.doi.org/10.1192/j.eurpsy.2021.934.
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IntroductionTelepsychiatry (TP) can provide an alternative to traditional face-to-face (FTF) assessments. However, TP in the emergency room setting is much less prevalent, probably due to lack of solid evidence about its effectiveness and acceptability.ObjectivesTo directly compare traditional FTF and TP modalities in the emergency room setting.MethodsPsychiatric patients (n=38) presented to the emergency room went through traditional in-person and videoconference TP interviews in varying order. Both FTF and TP interviewers that examined the patients as well as a third psychiatrist, acting as an observer for both modalities, determined the diagnosis, disposition recommendation and indication for involuntary admission.ResultsRater decisions had a high matching on disposition and indication for involuntary admission (Cohen’s Kappa (CK) of 0.84/0.81, 0.95/0.87 and 0.89/0.94 for FTF-TP, Observer-FTF and Observer-TP, respectively). Although identical diagnosis matching between the raters was relatively low, the partial diagnosis matching was high (CK of 0.52/0.81, 0.52/0.85 and 0.56/0.85 for FTF-TP, Observer-FTF and Observer-TP, respectively). Telepsychiatry assessments had comparable acceptability in items such as psychiatrists’ certainty and interviewers’ and patients’ satisfaction.ConclusionsTP and FTF psychiatric assessments in the emergency room settings have similar validity and acceptability. Implementation of TP in emergency room settings might improve the mental health services’ quality and access especially for remote populations. TP is especially important during the COVID-19 pandemic to enable treatment for epidemiologically isolated patients and to protect the medical personnel.
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Falender, Allison E., Rainer Lanz, Daniel Malenfant, Luc Belanger, and JoAnne S. Richards. "Differential Expression of Steroidogenic Factor-1 and FTF/LRH-1 in the Rodent Ovary." Endocrinology 144, no. 8 (August 1, 2003): 3598–610. http://dx.doi.org/10.1210/en.2002-0137.
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Abstract Steroidogenic factor-1 (SF-1) (NR5A1) is an orphan nuclear receptor that plays a premier role in ovarian organogenesis. Recent studies document mRNA expression of the structurally related factor NR5A2 (FTF, LRH-1, SF-2) in the adult ovary and more specifically in granulosa cells and luteal cells but not theca cells. Conversely, SF-1 was shown to be expressed at higher levels in theca/interstitial cells. These latter observations raised the possibility that FTF/LRH-1 may control target gene expression in granulosa cells of developing follicles. Using quantitative PCR our results show that FTF/LRH-1 message is expressed at higher levels in the ovary than in liver or other tissues analyzed. We show by in situ hybridization and LacZ expression in ovaries of transgenic mice bearing an FTF-promoter-LacZ fusion gene that FTF/LRH-1 is selectively expressed in granulosa cells of rat and mouse ovaries and is not present in theca cells or interstitial cells. However, by a variety of approaches, we showed that SF-1 mRNA and protein are expressed in greater amounts than FTF/LRH-1 in granulosa cells of follicles at all stages of development. Expression of SF-1 mRNA and protein in granulosa cells was verified by in situ hybridization, immunohistochemistry of ovarian sections, and immunocytochemistry of cultured rat granulosa cells. The significance of SF-1 in regulating target gene activation was supported by EMSA. An abundant granulosa cell protein binding to the SF-1-binding motif (CCAAGGTCA) present in the aromatase promoter and an FTF/LRH-1 motif (TGTCCTTGAACA) in the α-fetoprotein promoter was supershifted by two SF-1-specific antibodies but not by an FTF antibody. Conversely, with the same probes, a less abundant protein/DNA complex present in liver and ovarian cell extracts was shifted by an FTF antibody but not by the SF-1 antibodies. SF-1 and FTF/LRH-1 were differentially regulated in vivo by estradiol, FSH and prolactin. Collectively these data indicate that granulosa cells of small and preovulatory follicles express both SF-1 and FTF/LRH-1 and that each orphan receptor may regulate target gene expression in these cells.
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Bishop, J. E., R. L. O'Reilly, K. Maddox, and L. J. Hutchinson. "Client satisfaction in a feasibility study comparing face-to-face interviews with telepsychiatry." Journal of Telemedicine and Telecare 8, no. 4 (August 1, 2002): 217–21. http://dx.doi.org/10.1258/135763302320272185.
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We carried out a pilot study comparing satisfaction levels between psychiatric patients seen face to face (FTF) and those seen via videoconference. Patients who consented were randomly assigned to one of two groups. One group received services in person (FTF from the visiting psychiatrist) while the other was seen using videoconferencing at 128 kbit/s. One psychiatrist provided all the FTF and videoconferencing assessment and follow-up visits. A total of 24 subjects were recruited. Three of the subjects (13%) did not attend their appointments and two subjects in each group were lost to follow-up. Thus there were nine in the FTF group and eight in the videoconferencing group. The two groups were similar in most respects. Patient satisfaction with the services was assessed using the Client Satisfaction Questionnaire (CSQ-8), completed four months after the initial consultation. The mean scores were 25.3 in the FTF group and 21.6 in the videoconferencing group. Although there was a trend in favour of the FTF service, the difference was not significant. Patient satisfaction is only one component of evaluation. The efficacy of telepsychiatry must also be measured relative to that of conventional, FTF care before policy makers can decide how extensively telepsychiatry should be implemented.
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Lee, Song F., Gillian D. Delaney, and Mohammad Elkhateeb. "A Two-Component covRS Regulatory System Regulates Expression of Fructosyltransferase and a Novel Extracellular Carbohydrate in Streptococcus mutans." Infection and Immunity 72, no. 7 (July 2004): 3968–73. http://dx.doi.org/10.1128/iai.72.7.3968-3973.2004.
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ABSTRACT The expression of fructosyltransferase (FTF), the enzyme that synthesizes fructan from sucrose, is regulated in the cariogenic bacterium Streptococcus mutans. However, the exact mechanism of FTF regulation is unknown. In this study, the role of a two-component regulatory system (covRS) in FTF expression was investigated. A CovR-defective mutant of S. mutans NG8 was constructed by homologous recombination. By use of immunoblotting, the mutant was shown to overexpress FTF in the absence of sucrose, while the wild type and a covRS-complemented mutant showed sucrose-inducible FTF expression. Reverse transcription-PCR showed that the ftf transcript levels were increased in the covR mutant, suggesting regulation at the transcriptional level. The covR mutant was also found to overproduce extracellular carbohydrate, and this phenotype was reversed by covRS complementation. Paper chromatographic studies and chemical tests showed that the extracellular carbohydrate contained glucose and glucuronic acid but not fructose. These results suggest that the extracellular carbohydrate was not fructan. The production of a glucose- and glucuronic acid-containing extracellular carbohydrate has not been reported for S. mutans and may be considered novel. In conclusion, the results indicate that the expression of FTF and a glucose- and glucuronic acid-containing carbohydrate was negatively regulated by the covRS two-component regulatory system in S. mutans.
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Farrugia, Thomas J., Mario Espinoza, and Christopher G. Lowe. "Abundance, habitat use and movement patterns of the shovelnose guitarfish (Rhinobatos productus) in a restored southern California estuary." Marine and Freshwater Research 62, no. 6 (2011): 648. http://dx.doi.org/10.1071/mf10173.
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Coastal elasmobranchs such as the shovelnose guitarfish (Rhinobatos productus) seasonally use bays and estuaries for mating, pupping and feeding. However, many human-populated coastal areas have been developed, making them unavailable to coastal fish populations. The Full Tidal Basin (FTB) of the Bolsa Chica Ecological Reserve, California, USA, was completed in 2006, with the aim to restore lost estuarine habitat in southern California. Monthly abundance surveys conducted inside the FTB between June 2008 and September 2009 showed that shovelnose guitarfish were present throughout the year. Over 96% of the individuals caught were juveniles and these were most abundant in waters between 20°C and 24°C. Concurrently, 23 shovelnose guitarfish were fitted with coded acoustic transmitters and continuously tracked within the FTB for 16 months. Telemetry data showed individuals remained inside the FTB for, on average, 73.9 days (range 15–172 days), and made few movements between the FTB and the ocean. Tagged individuals disproportionately used mud habitats and waters at temperatures of 22°C, both of which are more common in the FTB than the neighbouring coastal ocean. The present study examined the structure and functionality of a restored estuary and suggests that the FTB is important habitat for a benthic predator, a promising result three years after restoration.
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Barkhi, Reza, and John Brozovsky. "An Analysis of the Dynamics of a Distance Course." Journal of Educational Technology Systems 28, no. 4 (June 2000): 311–25. http://dx.doi.org/10.2190/fcmb-hun8-651v-lue9.
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The recent developments in telecommunications have created low-cost facilities for remote communication and interaction. Academic institutions are investigating the potential of this technology for distance education to create virtual classrooms. In a virtual classroom, students are dispersed geographically and their interaction with the course professor and other students is facilitated via electronic screen monitors that facilitate two-way audio-video interaction. Although this technology is being promoted to reach students who cannot be residents on campus, the dynamics of this technology on education is not well understood. This article reports the results of a study that compares the dynamics of a traditional classroom with a virtual classroom facilitated by two-way audio-video technology. The results indicate the Video-Mediated ( VM) students are not more inhibited to ask questions in class than are their Face-to-Face ( FtF) counterparts. The VM students use e-mail to ask questions while the FtF students ask questions more by visiting the professor's office. Both VM and FtF students rate the way lectures are delivered to be equally appropriate. Finally, FtF students interact with their group members to work on group projects in a face-to-face mode while students in a VM class use e-mail and phone to interact with their group members to work on collaborative joint projects. Although on most measures FtF and VM students do not differ substantially, both VM and FtF students perceive FtF interaction to be more appropriate for resolving conflicts on group projects. We also investigated outcome measures between the two FtF and VM groups. The Face-to-Face students did as well as Video-Mediated Students on midterms but the overall performance that consists of midterm grades, assignments, and group projects was better for FtF students than for VM students. Implications of the findings will be discussed.
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Hanna, Florensia Stevany. "SYRIA’S DEFENSE AND SECURITY POLICY IN ADDRESSING THE ISSUE OF FOREIGN TERRORIST FIGHTERS (PERIOD 2011-2016)." Sociae Polites 19, no. 2 (December 20, 2018): 92–104. http://dx.doi.org/10.33541/sp.v19i2.1647.
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The researcher is interested in researching the phenomenon of Foreign Terrorist Fighters (FTF) more in-depth. Why is Syria became the main objective of these terrorist fighters because the issue of FTF in Syria is still rare to get researched? The study aims to analyze the phenomenon of Foreign Terrorist Fighters why go to Syria and how the Syrian government’s response to this issue. This study uses FTF theory or concept to explain the FTF phenomenon, also defense and security policy to explain what procedure is used by Bashar al-Assad in the handling of FTF issues. What will be discussed in this research is on the implementation of Syria’s defense and security policy in handling the issue of Foreign Terrorist Fighters, as well as how it impacts on Syria’s security itself. The results of this study suggest that the Syrian government has had a positive impact in implementing its policy for Syria’s protection. The most significant is the reduced number of FTFs coming to Syria. The success of recaptured cities controlled by the previous FTF and more territorial supervision tightened.
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Warmund, Michele R., and Denny Schrock. "Instructor Attitudes toward Interactive Television for Training Master Gardeners at a Distance." HortScience 33, no. 3 (June 1998): 503b—503. http://dx.doi.org/10.21273/hortsci.33.3.503b.
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Master Gardener training was delivered via interactive television (IT) or face-to-face (FTF) in 1996 and 1997. Following 1997 training, instructors were surveyed to determine if the method of program delivery influenced their perceptions of Master Gardener training. Most instructors preferred FTF program delivery as compared to IT training. More preparation time was spent in developing lecture notes, text slides, and visual aids for IT vs. FTF training. Although instructors were more comfortable with FTF training than IT programming, their comfort level with IT training increased with experience. A major reason for instructor discomfort with IT was the lack of personal contact with trainees. Although lack of interactivity was identified as a limiting factor with IT training, trainees monopolizing time during sessions was a major constraint for FTF training. In spite of instructor preference for FTF Master Gardener training, nearly all instructors indicated a willingness to teach IT training again. Motivating factors for future IT training included less night time instruction, less need to travel, job efficiency, and the opportunity to use new technology.
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Avery, Lindsay M., Salvador Vernacchio, Lisa McLaughlin, Luigi Xerri, Greg Moeck, and Daniel Pevear. "1263. Assessment of Cefepime (FEP)-Taniborbactam (TAN) Human Exposures to Suppress the Emergence of Resistance among Serine (SBL)- and Metallo-β-Lactamase (MBL)-Producing Gram-Negative Bacteria (GNB) in a Hollow Fiber Infection Model (HFIM)." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S648. http://dx.doi.org/10.1093/ofid/ofaa439.1447.
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Abstract Background FEP-TAN (FTB) efficacy and safety are currently being evaluated in a Phase 3 trial (NCT03840148). TAN, a boronic acid-based β-lactamase inhibitor, restores susceptibility to FEP when resistance is driven by SBL or MBL (ie, NDM, VIM). This in vitro study assessed whether clinical FTB exposures suppress treatment-emergent resistance in pathogenic Enterobacterales and Pseudomonas aeruginosa. Methods Bioreactors (C2011, FiberCell) were inoculated with clinical GNB strains (N=6) using highly concentrated log phase cultures (> 108 CFU). Syringe pumps supplied humanized exposures of FEP (2 g), FTB (2 g/0.5 g), ceftazidime-avibactam (CZA, 2 g/0.5 g), each as 2 h infusions q8h, or meropenem-vaborbactam (MEV, 2 g/2 g q8h, 3 h infusion) for 7 days. Exposures were confirmed by UPLC-MS/MS for all agents. Subpopulations with elevated FTB MICs (4x) were monitored with drug-supplemented agar. CZA or MEV served as positive or negative controls for selected strains. Samples, serially removed from bioreactors, were saline-washed prior to quantitative culture to prevent drug carryover. Results All strains grew rapidly in the presence of FEP (Figure 1), consistent with resistance by broth microdilution (BMD, Table 1). With the addition of TAN, there was extensive killing of the total bacterial populations by FTB, and subpopulations with elevated FTB MICs were never recovered. Like FTB against Klebsiella pneumoniae (KP) BAA-1705, CZA initially decreased the inoculum to the lower limit of detection, but unlike FTB, allowed regrowth to 3.7 log10 CFU/mL by day 7. The first dose of FTB was bactericidal against VIM+ and NDM+ KP strains while regrowth occurred prior to 8 h of MEV and CZA challenge, respectively. Notably, early failure of MEV is discordant with susceptibility by BMD (MIC= 4 µg/mL). By day 7, FTB sterilized an OXA-48+ KP strain that when challenged by MEV, grew to 9.8 log10 CFU/ml at 24 h. Figure 1. Bacterial burdens observed in the HFIM when treated with FEP alone or FEP+TAN (FTB) Table 1. Characterization of strains assessed in the HFIM; minimum inhibitory concentration (MIC) values for treatments not assessed are included in parentheses. Conclusion In a 7-day HFIM with humanized exposures and high initial inoculums, FTB provided sustained bactericidal activity against multidrug-resistant Enterobacterales and P. aeruginosa strains harboring a diversity of β-lactamases and suppressed growth of resistant subpopulations. These data are crucial to inform understanding of the potential role for FTB in GNB infections and future clinical studies. Disclosures Lindsay M. Avery, PharmD, Venatorx Pharmaceuticals (Employee, Shareholder) Salvador Vernacchio, BS, Venatorx Pharmaceuticals (Employee, Shareholder) Lisa McLaughlin, BS, Venatorx Pharmaceuticals (Employee, Shareholder) Luigi Xerri, PhD, Venatorx Pharmaceuticals (Employee, Shareholder) Greg Moeck, PhD, Venatorx Pharmaceuticals (Employee, Shareholder) Daniel Pevear, PhD, Venatorx Pharmaceuticals (Employee, Shareholder)
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Lin, Tin-Chun. "Student learning performance and satisfaction with traditional face-to-face classroom versus online learning: Evidence from teaching Statistics for Business." E-Learning and Digital Media 19, no. 3 (February 23, 2022): 340–60. http://dx.doi.org/10.1177/20427530211059625.
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In this research, we investigated whether business students enrolled in a statistics course gained more by engaging in traditional face-to-face (FTF) learning or online learning. Empirical evidence suggested that students learned statistics more effectively when engaged with an instructor in a traditional FTF classroom versus through online learning; however, when the option of teaching virtually in fully online (ONL) classes was available, students successfully learned about statistics whether in a traditional FTF classroom or a ONL learning experience. In addition, evidence suggested that students’ overall satisfaction with the course and the instructor was higher in the FTF setting than in the ONL setting. Evidence also suggested that offering online zoom lecture meetings in the ONL setting remarkably enhanced students’ satisfaction with the course and the instructor and, importantly, reduced the gap in effective instruction between traditional FTF and ONL settings.
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Schulze, Julian, Pavle Zagorscak, Stephen G. West, Martin Schultze, and Stefan Krumm. "Mind the context—The relevance of personality for face-to-face and computer-mediated communication." PLOS ONE 17, no. 8 (August 25, 2022): e0272938. http://dx.doi.org/10.1371/journal.pone.0272938.
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A large body of research has examined the link between personality and face-to-face (FtF) communication knowledge, skills, abilities, and other characteristics (KSAOs). With the rise of digital media, text-based computer-mediated (CM) communication KSAOs have gained increasing attention. We conducted two studies to investigate how personality relates to KSAOs in the different contexts of FtF and CM communication. Contrasting perspectives hypothesize that the results in the FtF and CM contexts would be very similar or distinctly different. In Study 1 (n = 454), an online panel study, the Big Five personality dimensions were assessed and their relationships to FtF and CM communication KSAOs were investigated. Structural equation models and relative weight regression analyses showed that these personality dimensions, mostly extraversion and neuroticism, explained more variance in FtF as compared to CM communication KSAOs. Study 2 (n = 173), conducted in a laboratory context, showed similar results compared to Study 1. In addition, when the Big Five personality dimensions were assessed with a CM frame of reference, more variance was explained in CM than in FtF communication KSAOs. These results point to the importance of considering context effects in communication and in personality research: FtF and CM communication KSAOs need to be differentiated. If not properly contextualized, the relevance of personality and communication competencies in predicting criteria may be underestimated due to contextual mismatches.
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Hackel, Meredith, Mark G. G. Wise, and Daniel F. Sahm. "203. Activity of Cefepime in Combination with Taniborbactam (formerly VNRX-5133) Against Pseudomonas aeruginosa from a Global 2018-2020 Surveillance Collection." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S124. http://dx.doi.org/10.1093/ofid/ofab466.203.
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Abstract Background Taniborbactam is a novel cyclic boronate-based broad-spectrum β-lactamase inhibitor (BLI) with potent and selective inhibitory activity against both serine- and metallo-β-lactamases (MBLs). Taniborbactam restores the activity of cefepime (FEP) against many multidrug resistant organisms, including cephalosporin- and carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa (PA). We evaluated the in vitro activity of the investigational combination cefepime-taniborbactam and comparators against clinical isolates of PA collected during a 2018-2020 surveillance. Methods MICs of FEP with taniborbactam fixed at 4 µg/mL (FTB) and comparators were determined against 3,219 PA collected from 221 sites in 52 countries in 2018-2020. Resistant phenotypes were based on 2021 CLSI breakpoints. Acquired β-lactamase (BL) genes were identified via PCR/Sanger sequencing or whole-genome sequencing (WGS) for 516 isolates with meropenem (MEM) MIC ≥8 µg/mL, and for 94 randomly selected isolates with FEP or ceftazidime MIC ≥16 µg/mL. 186 isolates with FTB MIC ≥16 µg/mL, 16 with FTB MIC=8 µg/mL and one with FTB MIC=4 µg/mL were subjected to WGS. Results Overall, 28.7%, 26.2% and 20.3% of PA isolates were nonsusceptible (NS) to piperacillin-tazobactam (TZP), MEM or FEP, respectively (Table). FTB demonstrated potent activity (MIC50/90, 2/8 µg/mL; 94.2% inhibited at ≤8 µg/mL) against PA overall and inhibited between 63.4% (ceftazidime-avibactam [CZA] NS) and 82.1% (TZP NS) of isolates in the NS subsets compared to 0% to 69.1% S for comparators. Against the 111 strains carrying VIM or NDM MBL genes, 67.6% had FTB MICs ≤8 µg/mL, with 11.7% having FTB MICs of 16 µg/mL. Plausible explanations for elevated FTB MICs included IMP MBL genes, penicillin binding protein 3 variations, and/or possible efflux pump up-regulation. Conclusion FTB demonstrated potent in vitro activity against PA with different resistance profiles, including NS to FEP, MEM, and TZP, and to the BL/BLI combinations CZA, ceftolozane-tazobactam, and meropenem-vaborbactam. FTB was the most active agent tested against PA harboring VIM and NDM MBLs. These findings support the continued development of FTB as a potential new treatment option for challenging infections due to MDR PA. Disclosures Meredith Hackel, PhD MPH, IHMA (Employee)Pfizer, Inc. (Independent Contractor) Mark G G. Wise, PhD, IHMA (Employee)Pfizer, Inc. (Independent Contractor) Daniel F. Sahm, PhD, IHMA (Employee)Pfizer, Inc. (Independent Contractor)
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Cioffi, J. "The block-processing FTF adaptive algorithm." IEEE Transactions on Acoustics, Speech, and Signal Processing 34, no. 1 (February 1986): 77–90. http://dx.doi.org/10.1109/tassp.1986.1164799.
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Stalfors, Joacim, Ingela Björholt, and Thomas Westin. "A cost analysis of participation via personal attendance versus telemedicine at a head and neck oncology multidisciplinary team meeting." Journal of Telemedicine and Telecare 11, no. 4 (June 1, 2005): 205–10. http://dx.doi.org/10.1258/1357633054068892.
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Multidisciplinary team (MDT) meetings are used for establishing diagnosis, for tumour, node, metastasis (TNM) classification and for treatment in head and neck tumour patients in the western region of Sweden. Because of the distances, telemedicine was introduced to link the regional hospital to two of the three district general hospitals (DGHs). We evaluated the costs of presenting patients face to face (FTF) versus via telemedicine. Cost analyses were based on questionnaires completed by patients presented at the MDT meeting. A total of 39 patients were included in the FTF group and 45 patients in the telemedicine group. The cost analysis showed that FTF presentation cost SEK 2267 versus SEK 2036 by telemedicine (difference not significant). The small difference was explained by the fact that the responsible physician accompanied only six of 39 patients when presented FTF, but when presented via telemedicine the DGH physician always participated. A sensitivity analysis revealed that if the responsible physician always accompanied his/her patient for presentation FTF, the cost would be SEK 5366 per patient. This study shows that costs may be saved by carrying out MDT meetings by means of telemedicine instead of FTF.
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Milgrom, Jeannette, Brian G. Danaher, John R. Seeley, Christopher J. Holt, Charlene Holt, Jennifer Ericksen, Milagra S. Tyler, Jeff M. Gau, and Alan W. Gemmill. "Internet and Face-to-face Cognitive Behavioral Therapy for Postnatal Depression Compared With Treatment as Usual: Randomized Controlled Trial of MumMoodBooster." Journal of Medical Internet Research 23, no. 12 (December 8, 2021): e17185. http://dx.doi.org/10.2196/17185.
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Background Previous research has confirmed that symptoms of postnatal depression (PND) can be ameliorated through internet-delivered psychological interventions. Advantages of internet-delivered treatment include anonymity, convenience, and catering to women who are unable to access face-to-face (FTF) treatments. To date, no research has examined the efficacy of such interventions compared directly with FTF treatments in women clinically diagnosed with PND. Objective This study aims to compare the efficacy of one of the first web-based cognitive behavioral therapy (CBT) interventions (internet CBT+coach calls) for PND (MumMoodBooster [MMB]) with FTF-CBT in a randomized controlled trial (RCT). Methods In this study, 116 postnatal women with a Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition (DSM-IV) diagnosis of major or minor depression were randomized to MMB (39/116, 33.6%), FTF-CBT (39/116, 33.6%), or a treatment-as-usual (TAU) control condition (38/116, 32.8%). Diagnostic status was determined at baseline and at 21-week follow-up using the Structured Clinical Interview for the DSM-IV. Severity of anxiety and depressive symptoms was evaluated using the Depression Anxiety Stress Scales and the revised Beck Depression Inventory at baseline, 12-week follow-up (after treatment), and 21-week follow-up. Results Of the 116 participants, 107 (92.2%) had a diagnosis of major depression at baseline. Rates of remission from a major or minor depressive episode at 21 weeks in both the FTF-CBT and MMB groups were superior to that of the TAU group (56.6% and 47.7% less likely to be depressed, respectively) and they were not significantly different from each other. Although remission rates differed between TAU and FTF-CBT, growth models showed that, in terms of symptom reduction across time, the FTF-CBT treatment was not significantly better than TAU. By comparison, MMB was statistically superior to both TAU and FTF-CBT in reducing symptoms of depression, anxiety, and stress from baseline to the 21-week follow-up (large and moderate effect sizes). Thus, after 21 weeks, the average symptom scores for depression and anxiety of women receiving MMB were approximately half those of women in both the TAU and FTF-CBT groups. Conclusions In this RCT, MMB was at least as effective as FTF-CBT in achieving remission from a diagnosed PND episode. MMB was superior to TAU and FTF-CBT in encouraging and maintaining reduction of symptom severity over the 21-week follow-up for depressed postnatal women. These findings replicate results of prior studies on MMB that showed clinically significant improvements in depressive symptoms, and they provide direct empirical support that internet-delivered treatment for depressed postnatal women is a viable alternative to FTF treatment. The generalizability of the results needs to be examined in future research, as RCTs of internet-based versus FTF treatments necessarily involve a subset of people who are willing to undertake either modality of treatment. Trial Registration Australia and New Zealand Clinical Trials Registry (ANZCTR) ACTRN12613000881730; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=364683&isReview=true