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Journal articles on the topic 'Fs'

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Published: 4 June 2021
Last updated: 1 August 2024

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1

Lusher, Jeanne, and Meera Chitlur. "Kogenate�FS: antihemophilic factor rFVIII-FS." Therapy 3, no. 6 (November 2006): 699–708. http://dx.doi.org/10.1586/14750708.3.6.699.

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2

Lusher, Jeanne, and Meera Chitlur. "Kogenate®FS: antihemophilic factor rFVIII-FS." Therapy 3, no. 6 (November 2006): 699–708. http://dx.doi.org/10.2217/14750708.3.6.699.

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3

Mineraud, Julien, Sasitharan Balasubramaniam, Jussi Kangasharju, and William Donnelly. "Fs-PGBR." ACM SIGCOMM Computer Communication Review 42, no. 4 (September 24, 2012): 301–2. http://dx.doi.org/10.1145/2377677.2377741.

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4

Ministro, Bruno, Nuno Miguel Neves, and Sandra Guerreiro Dias. "Fs = μs Fn." Texto Digital 12, no. 1 (September 5, 2016): 195. http://dx.doi.org/10.5007/1807-9288.2016v12n1p195.

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http://dx.doi.org/10.5007/1807-9288.2016v12n1p195Fs = μs Fn é uma releitura a três vozes dos Homeóstatos de José-Alberto Marques. Partindo do desmembramento e recomposição digital do material sonoro, testam-se, com base nas possibilidades oferecidas pelo cruzamento entre a plasticidade vocal e as ferramentas digitais de manipulação, as potencialidades combinatórias que uma obra desta natureza encerra.
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5

Prous, J., and J. Castañer. "Ul-FS-49." Drugs of the Future 10, no. 8 (1985): 639. http://dx.doi.org/10.1358/dof.1985.010.08.70139.

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6

Castañer, J., and J. Prous. "FS-205-397." Drugs of the Future 17, no. 3 (1992): 185. http://dx.doi.org/10.1358/dof.1992.017.03.167154.

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7

Xiao-Wei, Li. "Josephson Effect in FS/I/N/I/FS Tunnel Junctions." Communications in Theoretical Physics 52, no. 4 (October 2009): 721–25. http://dx.doi.org/10.1088/0253-6102/52/4/32.

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8

Ambasht, Saket K., Brian F. Sweeney, Kevin A. Lang, Nicholas Conger, and Kevin O'Brien. "Comparison of flexible sigmoidoscopy (FS) in a system with primary care providers performing FS vs. gastroenterologists performing FS." American Journal of Gastroenterology 95, no. 9 (September 2000): 2526. http://dx.doi.org/10.1111/j.1572-0241.2000.02756.x.

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9

Steinmetz, S. A., and C. J. Kliewer. "Gas detection sensitivity of hybrid fs/ps and fs/ns CARS." Optics Letters 47, no. 6 (March 11, 2022): 1470. http://dx.doi.org/10.1364/ol.455427.

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10

HAVLÍČEK, A., J. BROŽEK, J. KIEFMANN, I. ČERMÁK, and V. HAVLÍN. "Automated fermentation system FS-70." Kvasny Prumysl 36, no. 1 (January 1, 1990): 9–12. http://dx.doi.org/10.18832/kp1990003.

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11

Yeob, Jongin, Sung Woo Hong, Won-Gun Koh, and In Park. "Enhanced Mechanical and Thermal Properties of Polyimide Films Using Hydrophobic Fumed Silica Fillers." Polymers 16, no. 2 (January 22, 2024): 297. http://dx.doi.org/10.3390/polym16020297.

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Polyimide (PI) composite films with enhanced mechanical properties were prepared by incorporating modified fumed silica (FS) particles while preserving their optical and thermal characteristics. The PI matrix was synthesized using a fluorinated diamine, a fluorinated dianhydride, and a rigid biphenyl dianhydride via chemical imidization. Commercially available FS particles, including unmodified FS particles (0-FS) and particles modified with dimethyl (2-FS), trimethyl (3-FS), octyl (8-FS), octamethylcyclotetrasiloxane (D4-FS), and polydimethylsiloxane (PDMS-FS) were used. Scanning electron microscope images and nitrogen adsorption–desorption isotherms revealed well-defined porous structures in the FS particles. The water contact angles on the composite films increased compared to those of the pristine PI films, indicating improved water resistance. The PI/0-FS films exhibited a typical trade-off relationship between tensile modulus and elongation at break, as observed in conventional composites. Owing to the poor compatibility and agglomeration of the PDMS-FS particles, the PI/PDMS-FS composite films exhibited poor mechanical performance and diminished optical characteristics. Although the longer-chained FS particles (8- and D4-FS) improved the tensile modulus of the PI film by up to 12%, a reduction of more than 20% in toughness was observed. The PI composite films containing the methylated FS particles (2- and 3-FS) outperformed 8- and D4-FS in terms of mechanical properties, with PI/3-FS films showing an over 10% increased tensile modulus (from 4.07 to 4.42 GPa) and 15% improved toughness (from 6.97 to 8.04 MJ/m3) at 7 wt. % silica loading. Except for the PI/PDMS-FS composites, all composite film samples exhibited more than 86% transmittance at 550 nm. Regarding thermal properties, the glass transition temperature (Tg) and thermal stability remained stable for most composite films. In addition, PI/3-FS films demonstrated enhanced dimensional stability with lower coefficients of thermal expansion (from 47.3 to 34.5 ppm/°C). Overall, this study highlights the potential of incorporating specific modified FS particles to tailor the mechanical, optical, and thermal properties of PI composite films.
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12

Shintani, Yasumi, Mitzilee Dyson, Ann E. Drummond, and Jock K. Findlay. "Regulation of Follistatin Production by Rat Granulosa Cells in Vitro*." Endocrinology 138, no. 6 (June 1, 1997): 2544–51. http://dx.doi.org/10.1210/endo.138.6.5190.

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Abstract The aims of this study were to apply enzyme-linked immunosorbent assays (ELISA) for human follistatins (FS) to measure total immunoreactive (ir-) rat FS and free rat FS, and investigate the regulation of production of total ir-FS and free FS by rat granulosa cells (GC) in vitro. Production of ir-inhibin was monitored as an index of GC function. The ELISAs for total ir-FS, based on an immunoradiometric assay developed recently for human FS, and free FS, based on capture of FS by a monoclonal antibody and detection by activin A binding, had sensitivities of 0.4 and 0.8 ng recombinant human (rh-) FS 288/ml, respectively, and did not cross-react with inhibin A, rLH, or FSH. rh-Activin did not cross react in the total ir-FS ELISA, but interfered with the measurement of free FS. Dilutions of GC-conditioned medium were parallel to the standard curve of rh-FS 288 for each assay. The values obtained in the free FS assay were 10- to 20-fold higher than those in the total ir-FS ELISA, suggesting that rat FS may be recognized by the antibodies differently than the human standard. Both total ir-FS and free FS production by undifferentiated GC from diethylstilbestrol (DES)-treated, immature rats increased with cell number and time in culture and were stimulated dose dependently by FSH, rh-activin A (except free FS, which was not measured because of interference), forskolin, and phorbol 12-myristrate. The effects of FSH and activin on FS production by undifferentiated GC were additive. There were significant effects of degree of differentiation of GC on basal FS production and responsiveness to FSH, LH, and rh-activin A. Both total ir-FS and free basal FS production increased up to 4-fold with the degree of differentiation of GC, produced by treating rats in vivo with DES (undifferentiated), DES plus FSH (partially differentiated), or DES plus FSH plus hCG (fully differentiated). The addition of FSH in vitro increased FS production by undifferentiated and partially differentiated GC, but not by fully differentiated GC. The only detectable effect of LH on FS production was on partially differentiated GC. Activin A stimulated total ir-FS production by undifferentiated and partially differentiated GC, but inhibited total ir-FS production by fully differentiated GC. Ir-inhibin production in these experiments was similar to that of FS with the following exceptions; phorbol 12-myristrate inhibited ir-inhibin production by undifferentiated GC, basal ir-inhibin decreased in fully differentiated GC, FSH stimulated ir-inhibin only in undifferentiated GC, and rh-activin A stimulated ir-inhibin at all stages. It is concluded that 1) FS protein production by cultured undifferentiated rat GC is up-regulated by FSH and activin, possibly via both protein kinase A and C pathways; 2) increasing GC differentiation is associated with a significant increase in basal FS production by rat GC and a change in the hormonal regulation of FS production; and 3) FS and ir-inhibin production by cultured rat GC can be differentially regulated. The results are consistent with the hypothesis that activin tone decreases within follicles as they develop due to increased production of the activin-binding protein FS.
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13

Intyre, Tom Mac. "The Party: For FS." Books Ireland, no. 215 (1998): 227. http://dx.doi.org/10.2307/20623687.

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14

Sullivan, A., H. Hamster, H. C. Kapteyn, S. Gordon, W. White, H. Nathel, R. J. Blair, and R. W. Falcone. "Multiterawatt, 100-fs laser." Optics Letters 16, no. 18 (September 15, 1991): 1406. http://dx.doi.org/10.1364/ol.16.001406.

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15

Mariotti, François, Jean-François Huneau, and Hélène Fouillet. "Reply to FS Dioguardi." American Journal of Clinical Nutrition 98, no. 2 (August 1, 2013): 508–9. http://dx.doi.org/10.3945/ajcn.113.065474.

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16

Yuan, Yayan, Qing Zhang, and Hui Kou. "Consistent-linear FS-domains." Topology and its Applications 268 (December 2019): 106893. http://dx.doi.org/10.1016/j.topol.2019.106893.

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17

Miroshnichenko, A. S., and S. V. Zharikov. "FS CMa Type Binaries." EAS Publications Series 71-72 (2015): 181–86. http://dx.doi.org/10.1051/eas/1571040.

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18

Georges, P., F. Salin, G. Le Saux, G. Roger, and A. Brun. "20 fs amplified pulses." Optics Communications 67, no. 4 (July 1988): 297–300. http://dx.doi.org/10.1016/0030-4018(88)90153-8.

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19

Cross, H. Z. "Registration of NDSCD, NDSK(FS)C1, and NDSL(FS)C1 Maize Germplasms." Crop Science 28, no. 1 (January 1988): 201–2. http://dx.doi.org/10.2135/cropsci1988.201.rgp.

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20

Breunig, Hans Georg, Ana Batista, Aisada Uchugonova, and Karsten König. "Cell optoporation with a sub-15 fs and a 250-fs laser." Journal of Biomedical Optics 21, no. 6 (June 1, 2016): 060501. http://dx.doi.org/10.1117/1.jbo.21.6.060501.

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21

Mumena, Walaa Abdullah. "Maternal Knowledge, Attitude and Practices toward Free Sugar and the Associations with Free Sugar Intake in Children." Nutrients 13, no. 12 (December 9, 2021): 4403. http://dx.doi.org/10.3390/nu13124403.

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Research addressing factors related to free sugar (FS) consumption among children in Saudi Arabia is lacking. We aimed to evaluate maternal knowledge, attitude, and practices toward FS and the associations with children’s intake of FS. This cross-sectional study included 424 Saudi children aged 6–12 years and their mothers. Data related to maternal knowledge, attitude, and practices were collected using an online survey. Data concerning children’s habitual intake of FS were collected through phone interviews using a validated food frequency questionnaire. Limited knowledge on FS was observed among mothers of children [median 7.00 [interquartile range 6.00–8.00] out of 11.0. Maternal knowledge was not correlated with maternal attitude or practices toward FS. Maternal knowledge towards FS did not predict children’s intake of FS, whereas maternal attitude and practices toward limiting the consumption of FS predicted lower intake of FS among Saudi children, particularly the FS consumed from solid food sources (B: −5.73 [95% confidence interval (CI): −9.79 to −1.66]) and (B: −6.85 [95% CI: −11.9 to −1.80]), respectively. Despite the limited knowledge pertaining to FS among mothers in Saudi Arabia, they were making efforts to limit their children’s consumption of FS.
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22

Paiva, Lisete, Elisabete Lima, Ana Neto, and José Baptista. "Seasonal Variability of the Biochemical Composition and Antioxidant Properties of Fucus spiralis at Two Azorean Islands." Marine Drugs 16, no. 8 (July 26, 2018): 248. http://dx.doi.org/10.3390/md16080248.

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This study evaluates, for the first time, the seasonal (winter and summer) and geographical (São Miguel–SMG and Santa Maria–SMA Islands) variability of Fucus spiralis (Fs) biochemical composition (dry weight basis) and antioxidant properties. Protein and carbohydrates presented higher values in Fs-SMGwinter, lipids, total dietary fiber, and energy value in Fs-SMAsummer, and ash and soluble dietary fiber/insoluble dietary fiber ratio in Fs-SMAwinter. The fatty acid (FA) profiles showed a lower SFA in Fs-SMGsummer, whereas MUFA and PUFA presented higher values in Fs-SMGsummer and Fs-SMGwinter, respectively. Excellent dietary ratios of n6/n3 PUFA and hypocholesterolemic/hypercholesterolemic FA were found, with lower values in Fs-SMAwinter and higher in Fs-SMGsummer, respectively. The highest total phenolics was found in Fs-SMAsummer acetone:water extract and total flavonoids showed the higher value in Fs-SMGwinter methanol extract. The best free radical-scavenging activity was observed in the Fs-SMAwinter methanol (EC50 = 0.045 mg/mL) and acetone:water (EC50 = 0.059 mg/mL) extracts. The ferric-reducing antioxidant power showed the best results in Fs-SMAwinter methanol extract (EC50 = 0.016 mg/mL) and Fs-SMAsummer acetone:water extract (EC50 = 0.017 mg/mL). The best ferrous ion-chelating activity was found in Fs-SMGwinter acetone:water extract. Overall, results revealed that F. spiralis nutritional and functional bioactivity values have geographical and seasonal variations and that its regular consumption may add benefits to human health.
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23

Wang, Qing-Bao, Xiao-Fan Wang, Hua Fan, Li Li, and Peng Ji. "Early changes in corneal densitometry after FS-LASIK combined with accelerated corneal cross-linking for correction of high myopia." International Journal of Ophthalmology 17, no. 7 (July 18, 2024): 1307–12. http://dx.doi.org/10.18240/ijo.2024.07.16.

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AIM: To observe the effects of femtosecond laser-assisted excimer laser in situ keratomileusis combined with accelerated corneal cross-linking (FS-LASIK Xtra) on corneal densitometry after correcting for high myopia. METHODS: In this prospectively study, 130 patients underwent FS-LASIK or FS-LASIK Xtra for high myopia. Their right eyes were selected for inclusion in the study, of which 65 cases of 65 eyes in the FS-LASIK group, 65 patients with 65 eyes in the FS-LASIK Xtra group. Patients were evaluated for corneal densitometry at 1, 3, and 6mo postoperatively using Pentacam Scheimpflug imaging. RESULTS: Preoperative differences in corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups in different ranges were not statistically significant (P>0.05). Layer-by-layer analysis revealed statistically significant differences in the anterior (120 μm), central, and total layer corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups at 1 and 3mo postoperatively (all P<0.05), the FS-LASIK Xtra group is higher than that of the FS-LASIK group. Analysis of different diameter ranges showed statistically significant differences between the FS-LASIK group and the FS-LASIK Xtra group at 1mo postoperatively in the ranges of 0–2, 2–6, and 6–10 mm (both P<0.05); At 3mo postoperatively, the FS-LASIK Xtra group is higher than that of the FS-LASIK group in the ranges of 0–2 and 2–6 mm (P<0.05). At 6mo postoperatively, there were no statistically significant differences in corneal densitometry between the FS-LASIK group and the FS-LASIK Xtra group in different diameter ranges (all P>0.05). CONCLUSION: There is an increase in internal corneal densitometry during the early postoperative period after FS-LASIK Xtra for correction of high myopia. However, the densitometry values decreased to the level of conventional FS-LASIK at 6mo after surgery, with the most significant changes observed in the superficial central zone.
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Wang, Hui-Chun, Po-Chou Chen, Chun-Hsiung Chou, Cherng-Gueih Shy, and Jo-Chi Jao. "COMPARISON OF VARIOUS MRI FAT SUPPRESSION TECHNIQUES ON A WATER-FAT PHANTOM AT 1.5 T." Biomedical Engineering: Applications, Basis and Communications 29, no. 02 (April 2017): 1750015. http://dx.doi.org/10.4015/s1016237217500156.

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Nowadays, magnetic resonance imaging (MRI) has been widely applied for diagnosis of soft-tissue diseases. Most clinical MRI protocols use fat suppression (FS) methods to suppress fat signal, reduce chemical shift artifacts, and increase conspicuity of lesions. To understand the advantages, disadvantages, and clinical applications of the most commonly used FS methods is an important issue. The aim of this study was to evaluate FS performance of six FS methods on a fat-water phantom at 1.5[Formula: see text]T. The six MRI methods included iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL), short inversion time inversion recovery (STIR), and four chemical presaturation (Chem Presat) methods. The phantom was composed of homogeneous oil-in-water emulsions with various fat contents ranging from 0 to 100% in increments of 10%. The difference between the suppressed fat fractions (FS fractions) and the true fat fractions of the phantom was used as an index of FS performance. The correlations and levels of agreement (LOAs) between the FS fractions determined using each FS method and the true fat fractions of the phantom were analyzed. From the phantom study, it was found that FSE T2 FS, STIR and IDEAL could achieve more accurate FS fractions than the other three methods. The FS fractions determined using FSE T2 FS, STIR and IDEAL were in a good agreement. On the contrary, T2-weighted spin echo Chem Presat had the most inaccurate quantification of FS fractions among these six FS methods. Both the ranks of signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) of the phantom were IDEAL [Formula: see text] FSE T2 FS [Formula: see text] STIR. The FS performance of these six FS methods in clinical use needs further study.
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25

Kalista, S., O. Schakman, H. Gilson, P. Lause, B. Demeulder, L. Bertrand, M. Pende, and J. P. Thissen. "The Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Pathway Is Mandatory for the Follistatin-Induced Skeletal Muscle Hypertrophy." Endocrinology 153, no. 1 (January 1, 2012): 241–53. http://dx.doi.org/10.1210/en.2011-1687.

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Myostatin inhibition by follistatin (FS) offers a new approach for muscle mass enhancement. The aim of the present study was to characterize the mediators responsible for the FS hypertrophic action on skeletal muscle in male mice. Because IGF-I and IGF-II, two crucial skeletal muscle growth factors, are induced by myostatin inhibition, we assessed their role in FS action. First, we tested whether type 1 IGF receptor (IGF-IR) is required for FS-induced hypertrophy. By using mice expressing a dominant-negative IGF-IR in skeletal muscle, we showed that IGF-IR inhibition blunted by 63% fiber hypertrophy caused by FS. Second, we showed that FS caused the same degree of fiber hypertrophy in wild-type and IGF-II knockout mice. We then tested the role of the signaling molecules stimulated by IGF-IR, in particular the Akt/mammalian target of rapamycin (mTOR)/70-kDa ribosomal protein S6 kinase (S6K) pathway. We investigated whether Akt phosphorylation is required for the FS action. By cotransfecting a dominant-negative form of Akt together with FS, we showed that Akt inhibition reduced by 65% fiber hypertrophy caused by FS. Second, we evaluated the role of mTOR in FS action. Fiber hypertrophy induced by FS was reduced by 36% in rapamycin-treated mice. Finally, because the activity of S6K is increased by FS, we tested its role in FS action. FS caused the same degree of fiber hypertrophy in wild-type and S6K1/2 knockout mice. In conclusion, the IGF-IR/Akt/mTOR pathway plays a critical role in FS-induced muscle hypertrophy. In contrast, induction of IGF-II expression and S6K activity by FS are not required for the hypertrophic action of FS.
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26

de Andrade, Marcel Levy, Elke Stedefeldt, Lais Mariano Zanin, Luis D’Avoglio Zanetta, and Diogo Thimoteo da Cunha. "Unveiling the food safety climate’s paths to adequate food handling in the hospitality industry in Brazil." International Journal of Contemporary Hospitality Management 33, no. 3 (February 19, 2021): 873–92. http://dx.doi.org/10.1108/ijchm-09-2020-1030.

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Purpose This study aims to explore whether the application of a positive food safety (FS) climate reduces the number of FS violations in the hospitality industry. Design/methodology/approach The sample comprised 271 food handlers in six hotels and 12 restaurants in Brazil. FS climate and risk perceptions were evaluated by self-applicable questionnaires. FS violations were evaluated through observations during the workday. Structural equation modeling with partial least squares was used to test four hypotheses. Findings The findings of this study suggest that a positive FS climate reduces the number of FS violations. It was also observed that risk perception moderated the relationship between FS climate and violations. Physical structure was also identified as a predictor of adequate FS practices. Practical implications The results indicate that restaurant owners and managers should invest in actions toward a positive FS climate. Originality/value It is evident that FS climate elements should be evaluated together, providing a better understanding of the organizational climate and FS culture. Additionally, the bi-directional effect of risk perception was discussed, affecting and being affected by adequate FS practices. To the best of authors’ knowledge, this is the first study to model the FS climate in the hospitality sector and discuss the implications.
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27

Koyanagi, Yuko, Yoshiyuki Oi, Kiyofumi Yamamoto, Noriaki Koshikawa, and Masayuki Kobayashi. "Fast-spiking Cell to Pyramidal Cell Connections Are the Most Sensitive to Propofol-induced Facilitation of GABAergic Currents in Rat Insular Cortex." Anesthesiology 121, no. 1 (July 1, 2014): 68–78. http://dx.doi.org/10.1097/aln.0000000000000183.

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Abstract Background: Propofol facilitates γ-aminobutyric acid–mediated inhibitory synaptic transmission. In the cerebral cortex, γ-aminobutyric acidergic interneurons target both excitatory pyramidal cells (Pyr) and fast-spiking (FS) and non-FS interneurons. Therefore, the propofol-induced facilitation of inhibitory transmission results in a change in the balance of excitatory and inhibitory inputs to Pyr. However, it is still unknown how propofol modulates γ-aminobutyric acidergic synaptic transmission in each combination of Pyr and interneurons. Methods: The authors examined whether propofol differentially regulates inhibitory postsynaptic currents (IPSCs) depending on the presynaptic and postsynaptic cell subtypes using multiple whole cell patch clamp recording from γ-aminobutyric acidergic interneurons and Pyr in rat insular cortex. Results: Propofol (10 μM) consistently prolonged decay kinetics of unitary IPSCs (uIPSCs) in all types of inhibitory connections without changing paired-pulse ratio of the second to first uIPSC amplitude or failure rate. The FS→Pyr connections exhibited greater enhancement of uIPSC charge transfer (2.2 ± 0.5 pC, n = 36) compared with that of FS→FS/non-FS connections (0.9 ± 0.2 pC, n = 37), whereas the enhancement of charge transfer in non-FS→Pyr (0.3 ± 0.1 pC, n = 15) and non-FS→FS/non-FS connections (0.2 ± 0.1 pC, n = 36) was smaller to those in FS→Pyr/FS/non-FS. Electrical synapses between FS pairs were not affected by propofol. Conclusions: The principal inhibitory connections (FS→Pyr) are the most sensitive to propofol-induced facilitation of uIPSCs, which is likely mediated by postsynaptic mechanisms. This preferential uIPSC enhancement in FS→Pyr connections may result in suppressed neural activities of projection neurons, which in turn reduces excitatory outputs from cortical local circuits.
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28

Castañeda, P., L. Moscona, and K. Masrouha. "The effect of femoral shortening in the treatment of developmental dysplasia of the hip after walking age." Journal of Children's Orthopaedics 13, no. 4 (August 2019): 371–76. http://dx.doi.org/10.1302/1863-2548.13.190029.

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Purpose The optimal treatment for late-presenting developmental dysplasia of the hip (DDH) is controversial. High tension forces after hip reduction increase the pressure on the femoral head, potentially causing avascular necrosis. Femoral shortening (FS) is commonly used as a means to decrease the pressure on the femoral head. We examined the effect of FS on the outcomes of patients with late-presenting DDH. Methods A total of 645 hips of a late-presenting DDH cohort treated with open reduction and iliac osteotomies were retrospectively reviewed; 328 hips had a FS performed (FS+) and 317 (FS-) had not. The mean age was 3.9 years (sd 1.55). We classified the hips with the Tönnis and International Hip Dysplasia Institute (IHDI) methods; and the Pediatric Outcomes Data Collection Instrument (PODCI), Iowa Hip Score (IHS) and Severin classification as outcome measurements. Results The FS- group had higher scores in PODCI (median 95 points; interquartile range (IQR) 78 to 91) and IHS (median 91 points; IQR 64 to 88) than the FS+ group (PODCI: median 94 points; IQR 69 to 89 points; IHS: median 89 points; IQR 62 to 87). The mean Severin scores were similar (FS- 2.65; FS+ 2.5; p = 0.93) but the FS– group had higher rates of good and excellent outcomes (FS- 56%; FS+ 41%; p < 0.00001) and lesser dislocation rates (FS- 6%; FS+ 14%; p = 0.16). Conclusion Although FS should be used when a hip cannot be reduced without undue tension, our results indicate that this procedure is not necessarily related to a better outcome. Level of evidence: Therapeutic, Level III.
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29

Gilson, Hélène, Olivier Schakman, Stéphanie Kalista, Pascale Lause, Kunihiro Tsuchida, and Jean-Paul Thissen. "Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin." American Journal of Physiology-Endocrinology and Metabolism 297, no. 1 (July 2009): E157—E164. http://dx.doi.org/10.1152/ajpendo.00193.2009.

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Follistatin (FS) inhibits several members of the TGF-β superfamily, including myostatin (Mstn), a negative regulator of muscle growth. Mstn inhibition by FS represents a potential therapeutic approach of muscle atrophy. The aim of our study was to investigate the mechanisms of the FS-induced muscle hypertrophy. To test the role of satellite cells in the FS effect, we used irradiation to destroy their proliferative capacity. FS overexpression increased the muscle weight by about 37% in control animals, but the increase reached only 20% in irradiated muscle, supporting the role of cell proliferation in the FS-induced hypertrophy. Surprisingly, the muscle hypertrophy caused by FS reached the same magnitude in Mstn-KO as in WT mice, suggesting that Mstn might not be the only ligand of FS involved in the regulation of muscle mass. To assess the role of activin (Act), another FS ligand, in the FS-induced hypertrophy, we electroporated FSI-I, a FS mutant that does not bind Act with high affinity. Whereas FS electroporation increased muscle weight by 32%, the muscle weight gain induced by FSI-I reached only 14%. Furthermore, in Mstn-KO mice, FSI-I overexpression failed to induce hypertrophy, in contrast to FS. Therefore, these results suggest that Act inhibition may contribute to FS-induced hypertrophy. Finally, the role of Act as a regulator of muscle mass was supported by the observation that ActA overexpression induced muscle weight loss (−15%). In conclusion, our results show that satellite cell proliferation and both Mstn and Act inhibition are involved in the FS-induced muscle hypertrophy.
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30

"10.5424/fs//fs/2010193-6843." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-6843.

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"10.5424/fs//fs/2010193-8495." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-8495.

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"10.5424/fs//fs/2010193-8560." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-8560.

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"10.5424/fs//fs/2010193-8604." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-8604.

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"10.5424/fs//fs/2010193-8694." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-8694.

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"10.5424/fs//fs/2010193-8858." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-8858.

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"10.5424/fs//fs/2010193-8927." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-8927.

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"10.5424/fs//fs/2010193-9046." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9046.

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"10.5424/fs//fs/2010193-9082." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9082.

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"10.5424/fs//fs/2010193-9094." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9094.

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"10.5424/fs//fs/2010193-9096." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9096.

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"10.5424/fs//fs/2010193-9097." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9097.

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"10.5424/fs//fs/2010193-9102." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9102.

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"10.5424/fs//fs/2010193-9104." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9104.

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"10.5424/fs//fs/2010193-9109." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9109.

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"10.5424/fs//fs/2010193-9131." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/2010193-9131.

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"10.5424/fs//fs/201019S-9286." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/201019s-9286.

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"10.5424/fs//fs/201019S-9290." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/201019s-9290.

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"10.5424/fs//fs/201019S-9310." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/201019s-9310.

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"10.5424/fs//fs/201019S-9312." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/201019s-9312.

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"10.5424/fs//fs/201019S-9314." CrossRef Listing of Deleted DOIs 1 (2000). http://dx.doi.org/10.5424/fs//fs/201019s-9314.

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