Dissertations / Theses on the topic 'Friedel Crafts alkylation'
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Burguin, Emilie. "Zirconia based solid acids for Friedel-Crafts alkylation reactions." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420266.
Full textGonçalves, de Almeida José Luis. "Alkylation du benzène par le 1-dodécène sur catalyseurs zéolithiques." Lyon 1, 1994. http://www.theses.fr/1994LYO10292.
Full textPOIRIER, JEAN-LUC. "Alkylation de l'isobutane par l'ethylene en presence de catalyseurs solides de friedel-crafts." Caen, 1994. http://www.theses.fr/1994CAEN2037.
Full textLaouadi, Ornella Laura Nathalie. "Enantioselective Friedel-Crafts reaction catalysed by alginate aerogels." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18622/.
Full textSmutek, Bernhard. "Réactions Organiques des Alcools en Conditions Hydrothermales." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20180.
Full textThis thesis aims to study and to apply reactions of alcohols under hydrothermal conditions.Studies on 1-phenyl-ethanediol show an aldolisation, followed by an intramolecular Friedel-Crafts type reaction and an aromatisation. Finally, it ends up by as 1-phenyl-naphthalene.Ethylene glycol reacts on itself with a strong dependence on the temperature and the solvent. The conversion of 1,2-propanediol showed similar dependences and obtained even the aromatic compound mesitylene and especially the amount of products proves dependence on the temperature and the duration of the reaction. The main compounds can be used as solvents, as biofuel and for syntheses, whereas the byproducts might be biocarburants after hydrogenation.The Friedel-Crafts type reaction is transferred to an intermolecular one. Naphthalene and phenol are studied in more detail. 0.05mol/L HCl are enough in order to benzylate an aromatic compound at 180°C. HCl can be replaced by acetic acid or formic acid, but even concentrations of 1.0mol/L do not achieve results as good as 0.05mol/L HCl. The recycling of the aqueous phase of these reactions is advantageous. Additionally, benzyl alcohol alkylates benzyl alcohol and thus it can polymerize. Higher temperatures lead to longer polymers. This polymerization can be used in the domain of nuclear fuel recycling in order to separate platinum group metals out of a model solution
Drouillard, Joe͏̈lle. "Utilisation de zéolithes dans les réactions de type Friedel-Crafts : acylation et alkylation du thiophène." Poitiers, 1995. http://www.theses.fr/1995POIT2266.
Full textHlatywayo, Tapiwa. "Coal fly ash and acid mine drainage based heterogeneous Fe catalysts Friedel-Crafts alkylation reaction." University of Western Cape, 2020. https://hdl.handle.net/11394/7295.
Full textThe catalytic support materials used in the present study are zeolite HBEA and MCM-41. These high silica zeolites were synthesised from coal fly ash (CFA) waste via a novel approach that involved a fusion step, acid assisted silica extraction and removal of Al, Ca and Na from the silica by treatment with oxalic acid. The generated silica was converted to HBEA and MCM-41 via conventional hydrothermal treatment. The metal incorporation onto HBEA was done via two approaches namely; liquid phase ion exchange (LIE) and wet impregnation (WI) while the loading on MCM-41 was only done via WI since the material does not possess exchange sites. The metal solution precursors were AMD and Fe extracted from CFA (FeAsh) via acid leaching followed by pH regulation by concentrated NaOH. This is the first time these solutions were tested as possible metal precursors in catalyst synthesis.
2021-08-30
Kirk, Andrew. "Mesoporous supports for the catalysis of Friedel-Crafts alkylation and cyclialkylation reactions with sulfur-containing aromatics." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq31041.pdf.
Full textMontagne, Fabienne. "Les sels de terres rares en catalyse hétérogène des réactions de Friedel-Crafts : applications en polycondensation." Dijon, 1997. http://www.theses.fr/1997DIJOS033.
Full textFishlock, Daniel. "The Catalytic Intramolecular Friedel-Crafts Acylation of Meldrum's Acid Derivatives and The Total Synthesis of Taiwaniaquinol B." Thesis, University of Waterloo, 2005. http://hdl.handle.net/10012/1226.
Full textThis method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil.
Mechanistic investigations were undertaken to determine the rate-determining step in the acylation sequence using Meldrum?s acid, as well as to examine the role of the Lewis acid catalyst. Enolizable Meldrum?s acid derivatives can react via an acyl ketene intermediate under thermal conditions, while quaternarized Meldrum?s acid derivatives are thermally stable and only act as effective Friedel-Crafts acylating agents in the presence of a Lewis acid catalyst.
The total synthesis of (±)-Taiwaniaquinol B was completed. This natural product was the first ever isolated containing an unusual 6-5-6 fused ring system, and it also contains a hexasubstituted aromatic ring, and two all-carbon quaternary centers. This synthesis was accomplished via an intramolecular Friedel-Crafts acylation/carbonyl a-tert-alkylation reaction that exploits the unique chemistry of Meldrum?s acid. This novel methodology can be used to access a variety of highly substituted fused ring systems of various sizes.
Gratais, Alexandre. "Chimie des acrylamides chiraux : nouvelles méthodologies et application à la synthèse de nouvelles architectures moléculaires." Thesis, Rouen, INSA, 2014. http://www.theses.fr/2014ISAM0013/document.
Full textReactions allowing carbon-carbon bond creation are essential tools in the field of organic synthesis. These reactions are used to access to more and more complex structures. However their control in the case of highly functionnalized partners is still a serious concern.Development of new methodologies based on the reactivity of aminoacid derivating chiral acrylamides is reported. A new version of pyrrole alkylation reaction was developed using the electrophilic behaviour of highly functionnalized chiral acrylamides. Pyrrole can be selectivly monoalkylated or dialkylated leading to new heterocyclic structures bearing peptidic sequences containing up to four aminoacids residues. Chiral acrylamides bearing a conjuguated allyltrimethylsilane moiety have been used as new reagent in highly diastereoselective and chemospecific towards aldehydes allylation reactions. This methodology was extended to α-aminoaldehydes allowing easy access to γ-aminoacidsanalogues
Joerger, Jean-Michel. "1. Catalyse asymétrique dans les liquides ioniques : applications à la réduction par transfert d'hydrogène et à l'époxydation ; 2. Réactions de substitutions électrophyles aromatiques avec des chloroformiates." Rennes 1, 2005. http://www.theses.fr/2005REN1S008.
Full textCourant, Thibaut. "Multi-fonctionnalisation d’imines : synthèse de composés aminés α-β-fonctionnalisés par procédé photocatalysé et réactions asymétriques organocatalysées." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112308.
Full textThe aim of this study is the development of new methodologies for imines functionalization by organocatalysed and photocatalysed processes.First, a photocatalysed alkylation reaction of enecarbamates have been described. The use of organometallic Iridium complexes allowed the double functionalization of enecarbamates leading to highly substituted imines surrogates. This process is a green alternative to the use of heavy metals and only needs visible light as an renewable energy source to proceed. This environment-friendly radical transformation has been submitted to mechanistic study.In a second part, an aza-Friedel-Crafts reaction organocatalysed by chiral Brønsted acid has been studied. The bi-fonctionnality of chiral phosphoric acids has been advantageously used to perform the Friedel-Crafts addition of various substituted indole to in situ generated acyl-iminium ions. The compounds obtained by this methodology are showing interesting biological activities on central nervous system. Finally, the first enantioselective Povarov reaction involving amino-heterocycles as 2-azadienes precursors has been reported. This reaction is based on previous lab reports and the synthesis of tetrahydroquinoline analogues has been described. The multicomponent reduction/Povarov reaction sequence catalyzed by chiral phosphoric acids derived gives a rapid access to a wide library of bioactives analogues
Breistein, Palle. "Development of highly enantioselective organocatalyzed transformations." Doctoral thesis, Mittuniversitetet, Institutionen för naturvetenskap, teknik och matematik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-15621.
Full textThaxton, Amber. "Synthesis of Novel Azetidines." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1764.
Full textGoma, Jean Richard. "Applications de l'alkylation catalysée par transfert de phase dans la synthèse de coumarines, de chromones, d'amides et de photoxyéthers d'intérêt thérapeutique." Paris 11, 1989. http://www.theses.fr/1989PA114820.
Full textFogain-Ninkam, Alain. "Synthèse de structures hétérocycliques incluant un motif isoindole par cyclisation intramoléculaire." Le Havre, 2000. http://www.theses.fr/2000LEHA0007.
Full textChin, Ami Jun-Yee. "Part A Development of a Fluorescence Resonance Energy Transfer assay or high throughput screening for catalysts in the desymmetrization of meso substrates Part B Application of hydrazide based catalyst in Friedel-Crafts alkylation." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27118.
Full textBeck, Daniel Antony Speedie, and beckautomatic@gmail com. "Stereoselective intramolecular Michael addition reactions of pyrrole and their application to natural product syntheses." The Australian National University. Research School of Chemistry, 2006. http://thesis.anu.edu.au./public/adt-ANU20070130.130009.
Full textEck, Geneviève. "Synthèse partielle de la frédéricamycine A." Paris 6, 1986. http://www.theses.fr/1986PA066466.
Full textParas, Nick Anthony Dervan Peter B. "Enantioselective organocatalytic Friedel-Crafts alkylations of heterocycles and electron-rich benzenes /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-06012004-190154.
Full textIraqi, Ahmed. "Activation des hydrocarbures alkylations sélectives de Friedel et Crafts en catalyse acide par transfert d'hydrure /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37606057s.
Full textVukovic, Vuk. "Synergistic effect of acids and HFIP on Friedel-Crafts reactions of alcohols and cyclopropanes." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF068.
Full textThe catalytic activation of alcohols towards dehydrative bond formation in the absence of pre-activation has become a major research interest over the past two decades. In this thesis, the peculiar synergistic effect of strong acids as catalysts in hexafluoroisopropanol (HFIP) as solvent on various classes of unstable carbocations in Friedel-Crafts chemistry was investigated. It was found that for the first time, Brønsted acid catalyzed Friedel-Crafts reactions of highly electronically deactivated primary benzylic alcohols proceeded smoothly due to the acid-induced aggregation phenomena in HFIP. A similar strategy was used for the activation of propargylic alcohols as a new route to selectively access CF3-substituted allenes and indenes from the same starting compounds. Furthermore, this catalytic system was succesfully applied for Friedel-Crafts reactions of unactivated and donor-acceptor cyclopropanes. Finally, it was discovered that HFIP can mitigate against classical carbocation rearrangement in Friedel-Crafts alkylations, allowing access to linear alkyl chain products in a single step from linear alkyl alcohols
Bush, Alexander Graham. "Part A: Design of new camphor-based hydrazide organocatalysts and their applications to enantioselective Friedel-Crafts alkylations Part B: The development of the palladium catalyzed addition of organoborates to alkynyl esters: Synthesis of trisubstituted olefins as single isomers." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28272.
Full textHlatywayo, Tapiwa. "Supported metal catalysts for friedel-crafts alkylation." 2013. http://hdl.handle.net/11394/3565.
Full textThe research focused on the synthesis, characterisation and activity of zeolite supported metal catalysts for the Friedel-Crafts alkylation of benzene with t-butyl chloride. Alkyl benzenes are traditionally produced via systems that employ the use of Lewis acids or strong mineral acids. There have been widespread concerns over these approaches based on their environmental impacts and separation difficulties. Recent approaches have endeavoured the much to use more environmentally eco-friendly systems and zeolites have proved to be versatile support materials. The use of zeolites has also shown to greatly improve product selectivity as well as easing separation constraints. However the adoption of zeolites on large scale Friedel-Crafts alkylation has been hampered by the high cost of zeolite production from commercial sources. On the other hand fly ash has been found to be a viable starting material for zeolite synthesis. Apart from that South Africa is faced with fly disposal challenges and there is continual accumulation of fly ash at the coal fired power stations, which provide about 77 % of the power produced in the country. In this light the use of fly ash will help to reduce the disposal constraints as well as providing a cheap starting material for zeolite synthesis. In this study the hierarchical Zeolite X has been successfully synthesised from fly ash via a hydrothermal treatment. The zeolite was then loaded with Fe/Mn via two approaches namely liquid phase ion exchange and incipient wetness impregnation. For comparison purposes seasoned commercial support materials namely HBEA and MCM- 41 were also loaded with the same metals and characterised with various techniques namely; HRSEM, EDS, HRTEM, XRD, SAED, ICP-OES and N2 adsorption analysis, It was found from the characterisation undertaken that the integrity of the respective supports was generally retained upon metal loading. Both the ICP-OES and the EDS proved that the desired metals were successfully introduced onto the zeolitic support materials. The calculated percentage metal loading for the catalysts prepared via incipient wetness impregnation was closely related to the actual values obtained from the ICP-OES analysis for both the monometallic and the bimetallic catalysts (Fe/Mn). It was observed that the amount of metal that can be introduced on a zeolite via liquid phase ion exchange is largely dependent on the cation exchange capacity of the zeolite Supported metal catalysts for FC alkylation Page v and of the catalysts prepared using 0.25 M Fe solution it was found that Zeolite X had the highest Fe wt% loading of 11.4 %, with the lowest loading of 2.2 % obtained with the MCM-41 supported catalyst. The XRD patterns for the both HBEA and the MCM-41 supported metal catalysts resembled the patterns of the respective prestine support materials except in the case of catalysts with anFe wt % of more than 10, which exhibited peaks due to the Fe2O3 crystallites. In the case of the hierarchical Zeolite X, the metal loaded support had a significant reduction in the XRD peak intensities. The prepared catalysts were tested for the alkylation of benzene with t-butyl chloride. The benzene was also used as the solvent. The alkylation reaction was carried out in a round bottomed flask under reflux conditions and stirring at a temperature of 45 oC over a period of 5 h. A total of 18 catalysts was tested and the highest percentage conversion of 100 % was obtained with the 10%FeH after a reaction time of 2 h. The general trend obtained with the majority of the catalysts was characterised with a rapid initial increase and then steady state was achieved. Generally after a reaction time of 3 h almost all the catalysts had reached steady state in terms of the percentage conversion obtained. The outcomes reflect that the inclusion of Mn does not enhance the conversion but rather decreases it. It was also found that the Mn was not active in the alkylation of benzene as shown by the inactivity of the 10%MnM, where 10% by weight Mn was loaded on MCM-41. However the other monometallic catalysts containing Mn supported on Zeolite X and HBEA were found to be active. The activity is attributed to the presence of Brønsted acid sites in these zeolites which are not present in MCM-41. The selectivity studies reflect that the inclusion of Mn does slightly improve the selectivity towards the formation of the monoalkylated product (t-butyl benzene). The highest selectivity of 91.1 % was obtained with the 10%FeMnM after a reaction time of 4 h. MCM-41 supported catalysts had a relatively higher selectivity compared to the other supports. Considering the Fe monometallic catalysts tested it generally can be said that the yield were in the order HBEA > MCM-41 > Zeolite X. It however should be noted that the percentage yield is calculated from the conversion and selectivity percentages, this implies that the factors affecting these parameters will consequently affect the percentage yield obtained. Supported metal catalysts for FC alkylation Page vi The alkylation reaction was found to be characterised by the formation of two intermediate products which could not be identified. These products were formed during the transient start up stages of the reaction and would disappear from the reaction mixture with longer reaction times, and after 3 h in almost all the reactions studied the intermediates were not detected in the reaction mixture. The main products found were the monoalkylated product (desired product) and the para isomer (1,4-t-di-butyl benzene). There were no other dialkylated isomers or trialkylated products detected. The formation of the para isomer was usually after a reaction time of 2 h in most reactions. The research managed to show that the hierarchical Zeolites X can be synthesised from fly ash and ion exchange and incipient wetness impregnation are appropriate approaches that can be used to introduce Fe/Mn onto the support materials studied. The catalysts prepared were active to varying degrees in the Friedel-Crafts alkylation of benzene with t-butylchloride, with the exception of the 10%MnM which was found to be inactive.
陳建宇. "Synthesis of the Indolyl-Nitroalcohols via the Friedel-Crafts Alkylation–Henry Reaction Process." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/djsup3.
Full text國立中正大學
化學暨生物化學研究所
106
In this thesis, we have synthesized a series of indole derived nitro alcohols containing multiple chiral centers by using Friedel-Crafts alkylation of indoles with nitroolefins followed by Henry reaction with different aldehydes. In addition, the structure of nitro alcohols, e.g. compound 37b, was confirmed by X-ray crystallographic analysis of the single crystal.
王星勳. "Organotungsten lewis acid catalyzed friedel-crafts alkylation and[2+2+2]cyclotrimerization reactions." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/89556292293678620121.
Full textChiu, Hui-Tzu, and 邱惠慈. "Novel Silver N-heterocyclic Carbene Complex Promoted the Palladium-Catalyzed Friedel-Crafts Alkylation Reaction." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/63726533720295244853.
Full text國立中興大學
化學系所
105
Indole and its derivatives are important central building blocks for various biologically active natural products, agrochemicals, and drugs. In particular, the 3-substitued indoles have advantages in medicinal chemistry due to its recurring presence among antiviral agents. The synthesis of 3-substitued indoles has attracted considerable attention from chemists. One of the most important methods to synthesize 3-substitued indole derivatives is accomplished by the Friedel–Crafts alkylation reaction of indoles to nitroalkenes. In this study, compound 21 was synthesized from o-phenylenediamine and triethyl orthoformate, followed by coupling with 4-iodoanisole in the presence of CuI to give compound 22. The bis-benzimidazolium salt 17b was obtained from 22 linked with dibromopentane, then reacted with silver oxide to form silver carbene complex 23 (NHC–Ag). Palladium carbene complex (NHC–Pd) was formed by metal–metal exchange of Pd(OAc)2 with 23 in situ to catalyze the Friedel–Crafts alkylation. The catalytic system comprised of Pd(OAc)2/NHC–Ag shows high efficiency for the Friedel–Crafts alkylation over an array of indoles and activated or non-activated nitroolefins in the presence of low Pd-catalyst loading (2 mol%) at 30 °C. Particularly noteworthy is that our results are the first successful application for NHC–Ag complex 23 directly catalyzed the C–C bond formation of nitroolefins with indoles. Accroding to preliminary study results, it is found that the 3-substitued indoles were obtained by the the Friedel–Crafts alkylation of indoles to nitroalkenes using NHC–Ag complex 23 (0.5 mol %) as a catalyst in moderate yield. Further studies for NHC–Ag complex catalyzed the Friedel–Crafts alkylation will be explored in due course. In conclusion, we have developed an efficient bis-benzimiadzolium salt and its silver complex which are air/moisture stable and accessible with simple synthetic steps. The Friedel–Crafts alkylation reaction of indoles with nitroalkenes was successfully carried out under mild conditions by using the catalytic system generated from NHC–Ag complex 23 and Pd(OAc)2 in situ, which improved the disadvantages of the high-loading of catalyst, the high reaction temperature and the long reaction time.
Chang, Chia-Hao, and 張嘉豪. "Organocatalytic Asymmetric Friedel-Crafts Alkylation through Electron-rich Phenols with Alkylideneindolenines: The Synthesis of Chiral Indole Derivatives." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/efb5m9.
Full text中原大學
化學研究所
107
Abstract Our purpose is to develop the organocatalytic asymmetric Friedel-Crafts alkylation reaction of electron-rich phenols to alkylideneindolenines generated in situ from arenesulfonylalkylindoles. These reactions were catalyzed by (thio)urea- based cinchona alkaloid bifunctional organocatalysts, producing chiral indole derivatives in yields (up to 99%) and enantioselectivites (up to 97%).
[Verfasser], Joni. "Development of a sustainable technology platform for the homogeneous Friedel-Crafts alkylation using acidic ionic liquid catalyst = Über die Entwicklung einer nachhaltigen Friedel-Crafts-Alkylierung mittels saurer ionischer Flüssigkeiten / vorgelegt von Joni." 2009. http://d-nb.info/997283629/34.
Full textParas, Nick Anthony. "Enantioselective Organocatalytic Friedel-Crafts Alkylations of Heterocycles and Electron-Rich Benzenes." Thesis, 2004. https://thesis.library.caltech.edu/2353/1/NParas.pdf.
Full textThe development of the first organocatalytic asymmetric Friedel-Crafts alkylation is described in the context of conjugate additions of pyrroles to a,b-unsaturated aldehydes. Catalytic amounts of chiral imidazolidinone salts are used to activate the electrophile component via reversible formation of iminium ions. Ensuing conjugate additions of pyrroles afford aldehyde products in good yield and high enantiopurity using a range of alkyl-, aryl-, and heteroatom-substituted enals and nucleophiles. This reaction demonstrates the feasibility of using iminium catalysis to promote reactions of electron-deficient olefins beyond simple cycloaddition reactions. Observations were also made regarding the role of Bronsted acid cocatalysts in these organocatalytic reactions. The synthetic utility of asymmetric conjugate additions of pyrroles was demonstrated in a concise, enantioselective synthesis of the analgesic Ketorolac.
An enantioselective organocatalytic conjugate addition of electron-rich benzenes to a,b-unsaturated aldehydes has been developed. A new chiral secondary amine promotes exclusive para-alkylation of dialkylamino-substituted benzenes in good yield and with a high degree of stereocontrol. The process tolerates a range of substitutents on the electrophile component as well as a high degree of flexibility in the ortho- and meta-positions on the benzene ring. Particularly, the unique ability of this methodology to efficiently generate bisbenzyllic stereocenters by addition of electron-rich benzenes to cinnamaldehyde derivatives is demonstrated.
A general procedure for the cleavage of dialkylamino substituents from aromatic rings has also been developed. To accomplish this cleavage, a dialkylaniline is first converted to the corresponding quaternary ammonium salt with methyl iodide or methyl trifluromethanesulfonate. In a second step, dissolving metal reduction of the salt liberates the deaminated arene in high yields for the overall process. A range of alkyl, aryl, and heteroatom substitutions at the ortho, meta, and para positions were tolerated without significant decrease in reaction efficiency or yield. Deamination of aniline substrates bearing stereogenic centers para to the dialkylamino functionality proceeded with complete retention of enantiopurity. The combined utility of the asymmetric aniline alkylation and the new deamination methodology was demonstrated in the first enantioselective synthesis of the anticholinergic drug (R)-Tolterodine.