Journal articles on the topic 'Francesco di Sale'

AbstractIn 1956 Ilaria Toesca published an article in Bolletino d'Arte on a group of 19th-century drawings of North European origin cntitled : 'Alcuni disegni delle gallerie di Venezia. The drawings in question were by the Englishman William Young Ottley and the Dutchmen David Pierre Giottin Humbert de Superville and Hcndrik Voogd. I confine my remarks to the latter, who lived in Rome from 1788 until his death in 1839. The drawings come from the bequest of the Milan art-lover Giuseppe Bossi, with whom Voogd had a good business relationship. Discussing a signed drawing by Voogd, Toesca attributed 21 other drawings to him. The signature on the Venetian sheet is not the only proof of Voogd's authorship. Further evidence is provided by the circumstance that it is a preliminary study for a worked-up wash drawing in Hamburg (Kunsthalle) and also that it was preceded by a sketch in the Amsterdam Historical Museum. The topographical particulars of these three drawings arc discussed here. The attribution of the other 21 drawings is made 'dubitativamente' by Toesca. In my opinion her doubts are justified. Neither stylistically nor technically do they bear a resemblance to the rest of Voogd's oeuvre. The fact that the motifs (landscapes, cattle, studies of trees and plants) do occur in Voogd's work probably led to the attribution. The back of one of the drawings is inscribed 'Londonio'. The sale catalogue of Bossi's bequest (1818) lists both the Voogd drawing and work by Londonio. Francesco Londonio (1723-1783) was a Milan engraver and draughtsman who is chiefly known for his prints. Various print rooms in Europe possess work by him. It appears that the drawings attributed to Voogd are really preliminary studies by Londonio which he used for his oeuvre of prints. Indeed, some of the motifs in a series of etchings in the Rijksprentenkabinet in Amsterdam derive from the Venetian drawings. I therefore conclude that the Gallerie dell'Accademia in Venice own only one (signed) drawing by Hendrik Voogd, purchased by Bossi personally from the artist during his second visit to Rome (1810), and that the name of the true artist - Francesco Londonio - was lost when the sheets were removed from the original collector's albums.

Abstract Recurrent hepatocellular carcinoma (HCC-R) after Liver Transplant (LT) is difficult to manage and often characterized by relevant aggressiveness and extrahepatic localizations. Currently TKIs are the only therapeutic option, but results in term of overall survival (OS) and progression-free survival are disappointing. Immune checkpoint inhibitors in association with recombinant humanized monoclonal antibody to VEGF were to be proved effective in non-LT patients with metastatic hepatocellular carcinoma in determining tumor stabilization and improved survival. However, as in LT patients immunotherapy may increase the risk of acute liver rejection, such combination therapy has not been used so far. We designed a proof-of-concept study to analyze safety and efficacy of Nivolumab and Bevacizumab in LT patients as treatment for HCC-R after LT. Combination therapy received nominal authorization from the Provincial Medicines Commission. Candidate patients underwent routine blood test (hepatic, renal, and cardiac function), echocardiogram and a total body CT as baseline assessment. Patients with creatinine higher than 1.5 ULN or with ejection fraction lower than 45% were excluded. Five patients who experienced HCC-R 2 to 8 years after LT with pulmonary, lymph node, adrenal, bones, and hepatic localization and were either intolerant to TKIs or had had progression on TKIs, were included. All recurrent tumors and extra-hepatic localizations were characterized by high biologic aggressiveness. Patients received Nivolumab infusion every 14 days at a dose of 240 mg. Total body CT scan was performed every 8 weeks. When progression disease (PD) was detected at CT scan, Bevacizumab was added at a dose of 5 mg/kg every 14 days. One patient received a single Nivolumab infusion but was withdrawn because of rapid tumor progression, eventually followed by death. Another patient experienced moderate/severe rejection, which resolved with 1g/day Methylprednisolone e.v. for 3[EV1] days followed by Prednisone 50mg/day for 1 week then tapered and stopped. This patient was maintained on double therapy without residual problems. The 4 alive patients are still on double therapy after a mean period of treatment of 36±21 weeks. Disease stability with the combination of Nivolumab/Bevacizumab has been achieved in all patients at hepatic and all extra-hepatic HCC localization but bone, where 2/2 patients experienced progression. It should be underlined, however, that progression was very slow and mean survival of these two patients on combination therapy is 54±2 weeks. Combination therapy was very well tolerated, with few side effects throughout treatment period. These results indicate that the combination Nivolumab/Bevacizumab can be safely used in liver transplant patients. The risk of acute allograft rejection is minimal and manageable. Bone metastases remain an unsolved issue and need further alternative therapeutic approach. For patients with hepatic or other extra-hepatic localization, this combination obtained a relevant and protracted stabilization of disease. Citation Format: Lorenza Di Marco, Alessandra Pivetti, Nicola De Maria, Francesco Giuseppe Foschi, Dante Romagnoli, Federico Casari, Cristian Caporali, Paolo Magistri, Barbara Catellani, Fabrizio Di Benedetto, Erica Villa. Combination therapy with Nivolumab/Bevacizumab is safe and effective in patients with recurrent hepatocellular carcinoma after liver transplant [abstract]. In: Proceedings of the AACR Special Conference: Advances in the Pathogenesis and Molecular Therapies of Liver Cancer; 2022 May 5-8; Boston, MA. Philadelphia (PA): AACR; Clin Cancer Res 2022;28(17_Suppl):Abstract nr PO003.

RESUMO: Políticas públicas de formação de professores e incentivo à docência como o Programa Institucional de Bolsas de Iniciação à Docência (PIBID/MEC), que tem como objetivo antecipar o vínculo entre os futuros professores e a sala de aula, fazendo uma articulação entre a educação superior e as escolas estaduais e municipais, não contemplam línguas adicionais como o italiano, o francês e o alemão. Tendo em vista essa lacuna, num esforço de resistência e união, professores do Departamento de Metodologia do Ensino e do Departamento de Língua e Literatura Estrangeira, da Universidade Federal de Santa Catarina, refletiram sobre a possibilidade de um subprojeto multidisciplinar que apoiasse essas línguas não contempladas no programa. O objetivo principal deste relato é expor como a experiência da interação entre professores universitários dos cursos de italiano, espanhol, inglês e francês; professores de espanhol e inglês da rede pública de educação de Santa Catarina e graduandos dos cursos de italiano, espanhol, inglês e francês têm criado um espaço de res(ex)istência nas discussões sobre o fazer docente e o ensino de língua-cultura na escola (MENDES, 2004; 2008; 2010; 2015). Como essa equipe e essa experiência multidisciplinar podem contribuir no processo de formação de professores em contexto remoto de ensino e como podemos fomentar o diálogo entre as línguas estrangeiras em nossas universidades são algumas questões norteadoras. É objetivo ainda apresentar o desenvolvimento do projeto durante a pandemia e sua contribuição para a formação dos alunos do curso de licenciatura, especialmente do curso de Italiano. Pela análise de material empírico e teórico estudado ao longo do projeto, procurou-se levantar algumas perspectivas tendo em vista que, de pequenas iniciativas como essas, como a proposta multidisciplinar, o empenho coletivo de professores de LE, a procura por uma bolsa alternativa à da Capes e o interesse e empenho da aluna bolsista, a área do italiano pôde acessar espaços mais democráticos dentro da Universidade e da escola.Palavras-chave: Ensino. Aprendizagem. Língua. Italiano. Pibid Multidisciplinar. ABSTRACT: Politiche pubbliche per la formazione degli insegnanti e incentivi come il Programma Istituzionale per le Borse di Iniziazione all'Insegnamento (PIBID/MEC), che mirano ad anticipare il legame tra i futuri insegnanti e l'aula, creare un collegamento tra l'istruzione superiore e le scuole statali e comunali, non include lingue aggiuntive come l'italiano, il francese e il tedesco. In considerazione di questa lacuna, in uno sforzo di resistenza e di unione, professori del Dipartimento di Metodologia Didattica e il Dipartimento di Lingua Straniera e Letteratura dell'Università Federal de Santa Catarina hanno riflettuto sulla possibilità di un sottoprogetto multidisciplinare che supportasse queste lingue non incluse nel Programma. L'obiettivo principale di questa presentazione è quello di esporre come l'esperienza dell'interazione tra docenti universitari di corsi di italiano, spagnolo, inglese e francese; insegnanti di spagnolo e inglese della rete di istruzione pubblica e laureandi di corsi di italiano, spagnolo e inglese hanno creato uno spazio di resistenza nelle discussioni sulla didattica e l'insegnamento della lingua-cultura a scuola (MENDES, 2004; 2008; 2010; 2015). Come questo team e questa esperienza multidisciplinare possono contribuire al processo di formazione degli insegnanti in un contesto di insegnamento remoto e come possiamo promuovere il dialogo tra le lingue straniere nelle nostre università sono alcune questioni guida. Si propone anche di presentare lo sviluppo del progetto durante la pandemia e il suo contributo alla formazione degli studenti del corso di laurea, in particolare il corso di italiano. L'analisi del materiale empirico e teorico ci ha aitutato ad elevare alcune prospettive in vista di piccole iniziative come la proposta multidisciplinare, l'impegno collettivo degli insegnanti di LE, la ricerca di una borsa di studio alternativa e l'impegno della studente, così l'italiano ha potuto accedere a spazi più democratici all'interno dell'Università e della scuola.Parole chiave: Insegnamento. Apprendimento. Lingua. Italiano. Pibid Multidisciplinare. ABSTRACT: Public policies for teacher training and incentive to teaching such as the Institutional Program for Teaching Initiation Scholarships (PIBID/MEC), which aims to anticipate the link between future teachers and the classroom, making a link between higher education and state and municipal schools, does not include additional languages such as Italian, French and German. In view of this gap, in an effort of resistance and union, professors from the Department of Teaching Methodology and the Department of Foreign Language and Literature of the Universidade Federal de Santa Catarina reflected on the possibility of a multidisciplinary subproject that would support these languages not included in the program. The main objective of this presentation is to expose how the experience of the interaction between university professors of Italian, Spanish, English and French courses; teachers of Spanish and English of the public education and undergraduates of Italian courses, Spanish and English have created a space of res(ex)istência in the discussions on the teaching and language-culture teaching at school (MENDES, 2004; 2008; 2010; 2015). How this team and this multidisciplinary experience can contribute to the teacher training process in a remote teaching context and how we can foster dialogue between foreign languages in our universities are some guiding issues. It also aims to present the development of the project during the pandemic and its contribution to the training of students of the undergraduate course, especially the Italian course. The analysis of empirical and theoretical material, also in view of the formal documents of Santa Catarina, sought to raise some perspectives with a view to small initiatives such as the multidisciplinary proposal, the collective commitment of LE teachers, the search for an alternative scholarship t and the interest and commitment of the scholarship student, the Italian area was able to access more democratic spaces within the University and the school.Keywords: Teaching. Learning. Language. Italian. Multidisciplinary Pibid.

Background:Hip Osteoarthritis (OA) is a widespread disease characterized by pain and functional impairment, which, particularly in the elderly, may compromise overall health and quality of life. In the last decades, Intra-articular (I.a.) injections of hyaluronic acid (HA) gained more space among the conservative treatment of OA because of their beneficial effects and positive outcomes without relevant complications. (1,2). An innovative and patented formulation containing hybrid cooperative complexes of sodium hyaluronate 2.4% + sodium chondroitin non-sulfated 1.6% of biotechnological origin (HA-SC) has been recently developed for the I.a. treatment of hip OA and evaluated in a pilot study (3).Objectives:1) Primary aim: Evaluation of the safety of HA-SC in the treatment of symptomatic hip OA; 2) Secondary aim: Evaluation of the efficacy of HA-SC in terms of pain reduction (VAS) and function improvement (Lequesne) of the affected hip joint.Methods:This is a pilot, multicentric, open, prospective study. The following inclusion criteria were established: Patients (both genders) aged ≥ 40 years suffering for primary hip OA confirmed by X-Ray; Grade I-II-III according to K&L grading scale; Basal VAS pain at the target hip > 40 mm; Failure of at least two lines of conservative treatments. All patients underwent a single I.a. hip injection of a 3mL vial of HA-SC and followed-up for six months.Results:48 patients have been enrolled and completed the study. The treatment was generally well-tolerated, with only ten patients out of 48 (20.8%) reporting local effects mainly consisting of injection site pain and arthralgia localized in the treated area. All these patients completed the study. The treatment with HA-SC was associated with a statistically significant decrease of VAS scale from a basal value of 67.5 (mean) to 22.8 (mean, p<0.0001) at the end of the observation period at six months, with a statistically significant decrease at seven days of follow-up evaluation (29.3, mean, p<0.0001). The mean Lequesne’s Index total score after the single injection of HA-SC decreased from a baseline value of 10.4 (mean) to 5.1 (mean, p<0.0001) at six months. The decrease was marked and significant also at any of the other evaluated time point (p<0.0001).Conclusion:A single I.a. injection of the innovative formulation containing hybrid cooperative complexes of sodium hyaluronate + sodium chondroitin non-sulfated (HA-SC) showed to be well tolerated and safe in the treatment of symptomatic hip OA. A rapid and significant decrease in hip pain (VAS) and Lequesne’s Index was also observed starting immediately after the I.a. injection and lasting until the end of the follow-up period. However, conservative treatment of hip OA is still challenging. This new formulation could represent a promising, long-lasting, and effective I.a. treatment.References:[1]Papalia R. et al. J. Biol. Regul. Homeost. Agents 2017; 31 (4 Suppl. 2): 103-109.[2]Abate M. et al. Int. J. Immunopathol.Pharmacol. 2017; 30 (1): 89-93.[3]IBSA Data on file.Acknowledgments:The author thanks all the investigators of the study: Costantino Cosimo, UO Medicina Riabilitativa, Azienda Ospedaliero-Universitaria di Parma, Italy; Fortina Mattia, Unità di Ortopedia Universitaria, AOU Senese Policlinico Santa Maria alle Scotte, Italy; Sadile Francesco, II Ortopedia - Ortopedia Infantile, Università degli studi di Napoli Federico II, Italy; Salini Vincenzo, Clinica Ortopedica e Traumatologica, Ospedale SS Annunziata di Chieti, Italy; Voglino Nicola, UO Ortopedia e Traumatologia, Ospedale Alto Tevere Città di Castello Azienda USL Umbria 1, ItalyDisclosure of Interests:Rocco Papalia Speakers bureau: Speaker for IBSA

Abstract INTRODUCTION: Metastatic pancreatic ductal adenocarcinoma (PDAC) represents an unmet clinical need because the lack of effective treatment strategies and a very poor prognosis. Here we propose a novel therapeutic strategy, based on the repurposing of valproic acid (VPA), a safe and generic drug with epigenetic modulating activity, and simvastatin (SIM), a widely used generic cholesterol lowering drug, in combination with the standard gemcitabine/nab-paclitaxel (GEM/NP) treatment in metastatic PDAC setting. METHODS: Synergistic anti-tumor effect of the combined treatment was assessed in PANC1, ASPC1, PANC28 and BxPC3 PDAC cell lines in vitro by evaluating combination index, apoptosis, clonogenic capability, tumor spheroids and fibroblasts/tumor cells microtissues growth. Antitumor effect was confirmed in vivo on heterotopic and orthotropic xenograft PANC1 models in athymic mice. Expression and functional role of TGF-β and downstream epithelial-to-mesenchymal-transition (EMT) markers were studied by Ingenuity pathway analysis (IPA), mRNA and protein expression and by cell migration scratch assay. RESULTS: We showed, both in vitro and in vivo, the ability of VPA/SIM combination, used at low dosages, to synergistically improve the anti-proliferative and pro-apoptotic effect of chemotherapy (GEM/NP). Mechanistically, VPA/SIM treatment, alone or in combination with chemotherapy, induced e-Cadherin and impaired vimentin and ZEB-1 expression, functionally linked to the synergistic inhibition of cell migration. In line, IPA highlighted a protein network connecting HDACs and HMGCR, the targets of VPA and SIM respectively, with the two main EMT markers. Notably, the most significantly cancer enriched features associated with this network were “migration of tumor cell lines”, “fibrosis” and “invasion of tumor cell lines”, and TGFβ emerged as a hierarchical dominant network- node. Indeed, VPA/SIM inhibited TGFβ transcription and TGFβ-regulated EMT gene expression in PDAC cells. Consistently we also observed a significant reduction of circulating TGFβ1 levels in mice treated with VPA/SIM in combination with GEM/NP, paralleled by a reduced fibrosis on PDAC xenograft tumor sections, confirming the involvement of TGFβ functional down-modulation in the mechanism of VPA/SIM antitumor synergistic interaction and chemo-sensitization. CONCLUSIONS: Overall, we proposed a novel combination strategy, based on two safe and generic drugs, able to sensitize a widely employed regimen in metastatic PDAC patients, that warrant further clinical evaluation. Citation Format: Maria Serena Roca, federica iannelli, maria rita milone, veronica barile, cristina testa, tania moccia, carlo vitagliano, fabiana tatangelo, di gennaro elena, antonio avallone, francesca bruzzese, alessandra leone, alfredo budillon. Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1840.

Ulf G. Haxen: Rome – Cradle of the Hebrew Book The Royal Library in Copenhagen has, throughout the twentieth century, received two substantial collections of Hebraica and Judaica. In 1933 the library acquired the private library of chief rabbi and professor David Simonsen, which amounted to an impressive 40,000 manuscripts, books and correspondence of scholarly importance. Dr. Lazarus Goldschmidt escaped Nazi Germany in 1938 and managed to bring his 2,500 volumes of Hebraica and Judaica, including 43 immaculate and well preserved incunables, safely to London. His entire collection of rare Hebrew books was purchased by the Royal Library for a moderate sum in 1949 because Goldschmidt was “honoured to have his books incorporated in Bibliotheca Simonseniana.”Both scholars were recognised authorities in their own right, Simonsen as philologist in Semitics and specialist in Jewish booklore, and Goldschmidt as a renowned bibliophile and connoisseur of 15th century Hebraic incunables. His 46 rare incunables were eventually listed in Victor Madsen’s catalogue of incunables (1935–1963).The art of printing was born c.1455 in Mainz (Germany) with Johan Gutenberg’s printed edition of the bible. Among scholars it was generally believed that migrating Christian and Jewish apprentices carried the revolutionising “black art” of printing from Mainz to Spain and Italy. Coincidentally enough, the first two dated Hebrew works appeared in print thirty years after Gutenberg in the exact same year in southern and northern Italy respectively: these being the Rashi commentary on the Jewish bible issued 17th February 1475 in Reggia di Calabria and printed by Abraham Garton ben Isaac, and the Arba’ah turim in Piove di Sacco near Venezia published by Meshullam Cusi on 3rd July 1475.These two books were for a long time considered to be the first books printed with Hebrew types. The famous Christian scholar of Hebraica, Giambernardo de Rossi, who was the fortunate owner of the allegedly “first” cradle book from Reggia, subsequently published the first census of Hebrew incunables in Annales hebraica-typographica saeculi XV (1795). The scene was thus set for the future scholarly research of the undated incunables labelled “Roma, ante 1480” (Rome, before 1480) by de Rossi. The present essay discusses five of these incunables, all of which are described in Victor Madsen’s catalogue as printed in “Roma, ante 1480”; an approximated date which needs correcting. David Simonsen refers in passing to “the three printers of Rome” viz. Obadiah, Menasseh and Benjamin, as supposedly having been active in a printing press in Rome. The incunable with Salomon ben Abraham ibn Aderet (Raschba) Teschubot sche’elot. (“Answers to Questions”) dated “before 1980” is a case in point (#4332 in Victor Madsen’s catalogue), furnished with an earlier approximate publishing date c.1469–1472 no. 55 in the Offenberg census (1990) and eventually with REX online catalogue Inc. Haun in 2015.The best known printing press in Rome was created by the two German printers Conrad Sweynheym & Arnold Pannartz who established their first workshop at Santa Scolastica at Subiaco in the Sabine Mountains outside Rome in 1464, where they published several unique Latin works and introduced a Greek typeface. In 1467 they moved the press to the city of Rome in order to get closer to the reading and profitable public. In 1467 they moved the press to Rome in order to get closer to their reading public – and their profits. Here they were privileged to be housed in Palazzo Massimo by the proprietors Pietro and Francesco Massimo. What is more, they began working under the patronage of the respected humanist Giovanni Andrea Bussi, who was editor in charge.It is safe to conjecture that the Hebrew press was born in this milieu, as indeed suggested by Edwin Hall: “… a casual remark of Bussi in the preface to the Latin Bible hints at a possible connection between Sweynheym and Pannartz and what are thought to be the earliest printed books in Hebrew. These books, which contain no indication of date or place of printing, are the work of obscure printers named Obadiah, Manasseh, and Benjamin de Roma and constitute the most primitive surviving examples of printing in Italy.”I thank Dr. Ann Brener, Specialist in the Hebraic Section at the Library of Congress for supplying additional bibliographic references.

BackgroundA highly controversial question is whether or not corticosteroids should be prescribed for patients with early diffuse cutaneous systemic sclerosis (dcSSc). Although the painful and disabling features of early dcSSc (including tight itchy skin, contractures, fatigue) have an inflammatory basis and are likely to respond to corticosteroids, corticosteroids are a risk factor for potentially life-threatening scleroderma renal crisis.ObjectivesOur aim was to examine safety and efficacy of moderate dose prednisolone in patients with early dcSSc. Specific objectives were to evaluate whether moderate dose prednisolone reduced pain and disability, and improved skin score, and whether prednisolone was safe with particular reference to renal functionMethodsPRedSS set out as a Phase II, multicentre, double-blind randomised controlled trial, converted to open-label because of the Covid-19 pandemic. Patients were randomised to receive either moderate dose prednisolone (approximately 0.3 mg/kg) or matching placebo (or no treatment during open-label) for 6 months. The co-primary endpoints were the Health Assessment Questionnaire Disability Index (HAQ-DI) and modified Rodnan skin core (mRSS) at 3 months. Over 20 secondary endpoints included patient reported outcome measures reflecting pain, itch, anxiety and depression, fatigue and helplessness. 72 participants randomised 1:1 were planned and anticipated to yield 60 evaluable, giving over 80% power for each co-primary outcome in ANCOVA analyses [assumptions; HAQ-DI (α = 0.025, δ = -0.6, σ = 0.9, ρ = 0.6), mRSS (α = 0.025, δ = -5.5, σ = 8.2, ρ = 0.6)]. Mixed Models for Repeated Measures (week 6, month 3, month 6) were fitted with covariates trial arm, baseline score, anti-Scl-70 and their interactions with time point. An unstructured covariance matrix was assumed with the primary focus being the trial arm effect at 3 months.ResultsThe study terminated early due to the Covid-19 pandemic and consequently did not meet the recruitment target of 72 patients. Thirty-five patients (Table 1) were randomised (17 to prednisolone and 18 to placebo/control, 25 during the double-blind phase), of whom 34 completed the 3 month assessment. The adjusted mean difference between treatment groups at 3 months in HAQ-DI score was -0.10 (97.5% CI -0.29 to 0.10), p=0.25, and in mRSS -3.90 (97.5% CI -8.83 to 1.03), p=0.070, both favouring prednisolone but not significantly. Patients in the prednisolone group experienced less pain, helplessness and anxiety than control patients at 3 months: mean difference in pain scores -0.49, 95%CI (-0.93 to -0.06), p=0.027, in Hospital Anxiety and Depression (HADS) anxiety scores -2.05, 95%CI (-3.73 to -0.37), p=0.018, and in helplessness scores -1.54, 95%CI (-3.01 to -0.07), p=0.040. There were no renal crises.Table 1.Baseline characteristics of patients by treatment allocationCharacteristicPrednisolone (n=17)Control (n=18)Age (years)52.7 (14.0)55.3 (12.7)Female n (%)10 (59)9 (50)Duration of skin thickening (years)1.6 (0.8)1.7 (0.8)Anti-topoisomerase-1 n (%)5 (29)6 (33)Anti-RNA polymerase III n (%)6 (35)8 (44)HAQ-DI1.6 (0.8)1.7 (0.7)mRSS18.8 (7.9)23.5 (8.6)Values are mean (standard deviation) unless stated otherwiseConclusionPRedSS exemplified the challenges of running a clinical trial of an investigational medicinal product potentially associated with increased infection risk during the Covid-19 pandemic. Because PRedSS was terminated prior to target recruitment, it was underpowered, and any conclusions have to be extremely cautious. Although PRedSS suggested some benefit from moderate dose prednisolone, the small sample indicates the need for a further randomised trial.References[1]Herrick AL et al. Clinical trial protocol: PRednisolone in early diffuse cutaneous Systemic Sclerosis. J Scleroderma Rel Disord 2021; 6: 146-153.AcknowledgementsThis work was funded by Versus ArthritisDisclosure of InterestsDeb Griffiths-Jones: None declared, Yvonne Sylvestre Garcia: None declared, David Ryder: None declared, John Pauling Speakers bureau: Janssen, Consultant of: Janssen, Boehringer Ingelheim, Permeatus Inc, Sojournix Pharma and Astra Zeneca, Frances Hall Consultant of: Sobi, Roche, Grant/research support from: Alexion, Lilly, BMS, Actelion, Sobi, Peter Lanyon Grant/research support from: Vifor pharma, Justin Mason Consultant of: Pfizer, Novartis, Janssen and Roche., Christopher P Denton Speakers bureau: Janssen, Boehringer Ingelheim, Consultant of: GSK, Boehringer Ingelheim, CSL Behring, Corbus, Roche, Gesynta, Grant/research support from: Servier, GSK, Arxx Therapeutics, Horizon, Ariane Herrick Speakers bureau: Janssen, Consultant of: Arena, Boehringer-Ingelheim, Camurus, CSL-Behring, Gesynta, Grant/research support from: Gesynta

BackgroundAxial Spondyloarthritis (axSpA) can be distinguished in radiographic axSpA (r-axSpA) and non-radiographic (nr-axSpA). Secukinumab (SEC) is a novel treatment for axSpA, but data from real-life are still missing.ObjectivesTo evaluate, in a multicentric-Italian-cohort of axSpA patients on SEC followed for 24-months: a)the long-term effectiveness and safety of SEC; b)the drug-retention-rate and low-disease-activity (LDA) measured as BASDAI<4/ASDAS<2.1 and very-low-disease-activity (VLDA) measured as BASDAI<2/ASDAS<1.3; c)any differences in outcomes according to: line of biological treatment (naïve/non-naïve), gender (male/female), subtype of axSpA (r-axSpA/nr-axSpA).MethodsConsecutive patients with active axSpA (diagnosis according Assessment of SpondyloArthritis International Society ASAS criteria), who started SEC treatment, were evaluated prospectively. Data on disease characteristics, previous/ongoing treatments and imaging were collected. Disease-activity/functional/clinical scores and biochemical values were recorded at baseline (T0), at 6 (T6), 12 (T12), and 24 (T24) months. Effectiveness was evaluated over-time with descriptive statistics; multivariate Cox and logistic regression models were used to evaluate predictors of drug-discontinuation and LDA at T6. Infections, adverse events were recorded.Results249 patients (47.8% male; median age 51 years) were enrolled; 40.9% had HLA-B27; 53.8% had r-axSpA and 46.2% nr-axSpA. SEC was prescribed in 28.9% naïve and in 71.1% non-naïve patients. SEC effectiveness was shown as an improvement in several outcomes, such as ASDAS [T0=3.5(2.9-4.4) vs. T24=1.9(1.2-2.4);p=0.02] and BASDAI [T0=6.5(5.0-7.5) vs. T24=2.8(1.8-4.0);p=0.03]. After 24-months of treatment, 90.7% of naïve and 75.3% of non-naïve patients achieved LDA (BASDAI<4). At T24 naïve-patients showed better physical-functioning and lower disease-activity than non-naïve (Table 1). Similarly, at T24 we observed better physical functioning and lower inflammatory activity in males vs. females and in nr-axSpA vs. r-axSpA subjects. Retention-rate at T24 was 75% in the whole population, with some difference depending on gender (log-rank 9.319; p=0.002) (Figure 1). Treatment was discontinued in 61 patients (24.5%), mainly due to primary/secondary loss of effectiveness events (20 and 24 subjects, respectively), and only 17 patients (6.8%) due to adverse events (7 for reactions at the injection site or skin manifestations, 1 for gastro-intestinal complications, 1 for relapsing uveitis, 1 for hypertransaminasemia, 4 for severe recurrent infections, 3 due to the onset of new cancer).Table 1.Clinical, functional, disease activity and serological parameters of naïve (n=72) and non-naïve (n=177) axSpA patients during the 24-month follow-upT0T6T12T24BASMI [0-10], median (IQR)naïve2.0 (1.0-4.0)2.0 (0.0-3.3)1.0 (0.0-2.8)1.0 (0.0-2.0)non-naïve4.0 (1.0-7.0)4.0 (1.0-7.0)2.0 (1.0-4.0)2.0 (1.0-3.0)pp=0.03p=0.04nsnsHAQ-S [0-8], median (IQR)naïve0.8 (0.5-1.3)0.5 (0.0-1.0)0.3 (0.0-1.0)0.1 (0.0-0.5)non-naïve1.1 (0.8-1.5)1.0 (0.4-1.3)0.6 (0.4-0.9)0.7 (0.1-0.9)pp=0.04p=0.04p=0.04p=0.04ASDAS [0-6], median (IQR)naïve3.3 (2.7-3.9)2.1 (1.6-2.7)2.0 (1.2-2.8)1.3 (1.0-2.2)non-naïve3.7 (2.9-4.7)2.9 (2.0-3.7)2.1 (1.9-3.1)2.3 (1.6-2.3)pnsnsnsp=0.04ESR [0-25](mm/h), median (IQR)naïve14.0 (6.0-27.0)10.0 (4.0-19.5)8.0 (3.1-12.8)5.0 (2.0-15.0)non-naïve18.5 (10.0-31.3)15.0 (8.0-25.0)12.0 (6.0-20.0)12.0 (6.0-19.0)pp=0.04p=0.04p=0.04p=0.04Legend: BASMI: Bath Ankylosing Spondylitis Metrology Index; HAQ: Health Assessment Questionnaire modified for spondyloarthritis; ASDAS: Ankylosing Spondylitis Disease Activity Score; ESR: erythrocyte sedimentation rateConclusionIn a real-life clinical-setting, SEC proved to be safe and effective in axSpA, mainly in naïve-patients, with a notable drug-retention-rate. No differences were observed between r-axSpA and nr-axSpA.AcknowledgementsContributing authors of the Spondyloartritis and Psoriatic Arthritis SIR Study Group “Antonio Spadaro”: Alberto Cauli, MD, PhD, Rheumatology Unit, Department of Medical Sciences, AOU and University of Cagliari, Cagliari, Sardegna, Italy; Angelo Semeraro, MD, Rheumatology Unit, Martina Franca-ASL Taranto, Puglia, Italy; Leonardo Santo, MD, Rheumatology Unit, ASL BT Andria – DSS4 Barletta, Italy, Barletta-Andria-Trani, Puglia, Italy; Emanuela Praino, MD, Rheumatology Unit, ASL BT Andria – DSS4 Barletta, Italy, Barletta-Andria-Trani, Puglia, Italy; Giorgio Amato, MD, Rheumatology Unit, A.O.U. Policlinico S. Marco, Catania, Sicilia, Italy; Nicolò Girolimetto, MD, Rheumatology Unit, Department of Internal Medicine, Azienda USL-IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Emilia Romagna, Italy.Disclosure of InterestsGiacomo Cozzi: None declared, Mariagrazia Lorenzin: None declared, Maria Sole Chimenti: None declared, Salvatore D’Angelo: None declared, Antonio Marchesoni: None declared, Carlo Salvarani: None declared, Ennio Lubrano: None declared, Luisa Costa: None declared, Ylenia Dal Bosco: None declared, Elena Fracassi: None declared, Augusta Ortolan: None declared, Mario Ferraioli: None declared, Antonio Carriero: None declared, elisa visalli: None declared, RICCARDO BIXIO: None declared, Francesca Desiati: None declared, ALBERTO BERGAMINI: None declared, elisa pedrollo: None declared, Andrea Doria Grant/research support from: Novartis, Abbvie, Pfizer, MSD, Janssen, Rosario Foti: None declared, Antonio Carletto: None declared, Roberta Ramonda Grant/research support from: Novartis, Abbvie, Pfizer, MSD, Janssen

Esta segunda edição do volume 10 de 2017 traz várias contribuições no que diz respeito a novos objetos de estudo que as tecnologias e seu uso apresentam, além de diferentes olhares teórico-metodológico sobre eles.No primeiro eixo temático ou trilha, Linguística e Tecnologia, Andréa Pisan Soares Aguiar, em “Jogos eletrônicos e ensino de língua portuguesa: algumas reflexões”, propõe reflexões sobre o uso de jogos eletrônicos no ensino de língua portuguesa, especificamente, no ensino de gêneros textuais orais e escritos pela perspectiva sociointeracional da linguagem. Em “Convergência de mídias e o ensino de língua adicional como negócio eletrônico: análise do canal Open English Brasil no YouTube”, Bruna Helena Rech Rocha e Marcelo Spalding Perez fazem um levantamento teórico da convergência de mídias e suas implicações mercadológicas no segmento de ensino de Língua adicional, especificamente inglês. Priscilla Tulipa da Costa, em seu artigo “Os verbos frasais mais frequentes na escrita de aprendizes: um estudo contrastivo”, analisa dois corpora contendo ensaios escritos em inglês por estudantes universitários, os quais são examinados qualitativamente com o suporte do software AntConc para o tratamento e a análise dos dados.Na trilha Educação e Tecnologia, Pablo Rodrigo Bes Oliveira, em “Pokémon GO: discutindo dispositivos e a pedagogia dos jogos eletrônicos”, analisa práticas discursivas e não discursivas do jogo Pokémon GO, para desvendar os conceitos pressupostosnesse aplicativo, mostrando a visão consumista implícita em suas práticas. Tacia Rocha e Luciana C. F. Dias Di Raimo, em “Prática de leitura em sala de aula a partir dos pressupostos foucaultianos”, propõem uma prática de leitura como processo discursivo para o Ensino Superior, a partir de uma materialidade audiovisual com a temática tecnologia na educação. Em “O Ensino Híbrido como modalidade de interação ativa e reflexão crítica: relato de uma experiência docente no Brasil”, Débora Montenegro Pasin e Heloísa Orsi Koch Delgado relatam exemplos de ações na área da educação mediada por tecnologias no Brasil, na Europa e nos Estados Unidos, e demonstram o uso do modelo híbrido de ensino em uma disciplina do curso de Licenciatura em Letras em uma universidade particular brasileira. Alexandre Gomes Soares, em “Desafios da gestão em educação a distância: uma análise a partir da visão do gestor”, apresenta os resultados de uma pesquisa que teve como objetivo compreender os limites e possibilidades da gestão em curso a distância, com foco na percepção do gestor sobre sua gestão e sobre as consequências dela na atuação da equipe multidisciplinar de suporte. No artigo em inglês “Language learning in Blended And Tandem with Brazilian partners: flexible learning models”, Ulisses Oliveira compartilha uma experiência com um programa desenvolvido com enfoque na abordagem do blended learning, além de descrever uma mesclagem com o tandem learning num projeto piloto de uma disciplina curricular de Inglês na Escola de Negócios e Hospitalidade de uma universidade brasileira. Keyseane Santos da Silva, em “Análise reflexiva dos telecentros como espaços de inclusão digital no Amazonas”, discute a dimensão política e social dos telecentros comunitários em Manaus a partir da análise das políticas públicas de inclusão digital, assinalando pontos críticos e contribuindo para a compreensão da dinâmica de inclusão digital e desenvolvimento social no Amazonas. Wilkens Lenon Silva de Andrade, em “Reflexões sobre educação, sociedade e tecnologia, numa perspectiva libertadora”, analisa as contradições existentes entre a produção do conhecimento no contexto da cultura escolar, sobretudo no âmbito da academia, e a privatizazão do conhecimento a partir das novas práticas capitalistas no mundo globalizado. Em “Aplicativo digital: uma contribuição para o processo de ensino-aprendizagem”, Renata Barbosa Vicente e Matheus Yuri Bezerra da Silva Araújo apresentam a elaboração do aplicativo educacional “Escolinha do Letramento” e seu sistema de funcionamento para atender crianças quecursam entre o 1º e o 2º ano doensino fundamentalI. Sabrina Bagetti, Eunice Maria Mussoi e Elena Maria Mallmann, em “Fluência tecnológico-pedagógica na produção de Recursos Educacionais Abertos (REA)”, expõem resultados de uma investigação sobre as implicações da fluência tecnológico-pedagógica na produção de videoaulas no formato Recursos Educacionais Abertos (REA). Tiago Barbosa Souza e Maria Iara Zilda Návea da Silva Mourão, em “Ensinar francês por dispositivos móveis: uma experiência com Duolingo e WhatsApp”, relatam uma prática pedagógica que enfatizou o uso de ferramentas tecnológicas no ensino de língua francesa em uma universidade pública no ano de 2015.Iniciamos a trilha “Semiótica e Tecnologia” com o artigo de Mário Sérgio Teodoro da Silva Junior, “Formas da expressão animatorial: o sentido dos movimentos na animação Disney”, no qual ele explora, dentro da perspectiva da semiótica discursiva, alguns conceitos de desenho animado, presentes na produção de filmes de animação dos estúdios da Walt Disney. Em “Castelo Rá-Tim-Bum: Das práticas educativas às formas de vida”, Carolina Mazzaron de Castro e Naiá Sadi Câmara analisam, também pela semiótica francesa, estratégias de interação do programa Castelo Rá-Tim-Bum, considerando-o como um gênero didático pedagógico produzido no universo de práticas educativas não formais. Juliane Bassanufa Oliveira e Carlos Francisco de Morais, em “Anna Karenina no cinema: o primeiro encontro de Anna e Vronski nos filmes de 1935, 1948 e 2012”, analisam a primeira cena de encontro entre Anna Karenina e Alexei Vronski nas adaptações cinematográficas de 1935 (Clarence Brown), 1948 (Julien Duvivier) e 2012 (Joe Wright) e do texto literário de Tolstói (1877), mostrando as diferentes formas de realizar adaptações. Mauriceia Silva de Paula Vieira, Paula Silva Abreu, em “Letramento multimodal e argumentação: análise de estratégias persuasivas no anúncio publicitário”, analisam, com base na Gramática do Design Visual, anúncios publicitários veiculados no YouTube, com vistas a compreender como os diferentes recursos semióticos contribuem para que o anúncio possa significar mais e atingir o público-alvo.Na trilha “Produção Textual e Tecnologia”, o artigo de Jorge Fernando Barbosa do Amaral, “Arnaldo Antunes, poesia primitiva”, investiga, a partir da análise do poema “sem saída”, de Augusto de Campos, a poesia interativa, disponibilizada na internet, que tem como condição de desenvolvimento a interação direta com o interlocutor, além de analisar a poesia multimídia de Arnaldo Antunes a partir de seu exercício de manipulação dos recursos materiais da palavra. Por fim, em “Produção textual e autoria em ambiente virtual de aprendizagem: uma escrita dialógica”, Claudemir Sousa discute uma concepção dialógica de escrita, com base em uma interação virtual escrita de estudantes de uma universidade pública do estado de São Paulo, baseando-se nos pressupostos teóricos de Mikhail Bakhtin.Desejamos a todos uma produtiva leitura desses textos que trazemos à luz nesta edição.

Francesca Calabi é professora do Dipartamento di Studi Umanistici – Filosofia na Università degli Studi di Pavia, na Itália, onde leciona desde 2004 disciplinas de História da Filosofia Tardo-antiga. Seus cursos versam sobre temas como “O daimon de Sócrates” e “O asno de ouro” (ambas obras de Apuleio). Também lê, revisa e finaliza traduções suas em sala de aula, como a da “Carta de Aristeas a Filócrates”, um texto do séc. III a.C que descreve a tradução da Torá para o grego pelos 72 sábios e tradutores enviados a Alexandria a convite do então bibliotecário alexandrino, o peripatético Demétrio de Falero.

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