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1

Pal, Dilipkumar, Sushil Kumar, and Supriyo Saha. "ANTIHYPERGLYCEMIC ACTIVITY OF PHENYL AND ORTHO-HYDROXY PHENYL LINKED IMIDAZOLYL TRIAZOLO HYDROXAMIC ACID DERIVATIVES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 12 (December 1, 2017): 247. http://dx.doi.org/10.22159/ijpps.2017v9i12.22086.

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Objective: The paradigm was to establish phenyl and ortho-hydroxy phenyl linked imidazolyl triazolo hydroxamic acid derivatives as an antihyperglycemic agent.Methods: 100 mg/Kg body weight dose of phenyl and ortho-hydroxy Phenyl linked Imidazolyl triazolo Hydroxamic Acid derivatives (FP1-FP12) and standard glibenclamide were administered per os (p.o.) in the streptozotocin-induced hyperglycemic rats by glucose oxidase-peroxidase method and statistically evaluated by one way analysis of variance.Results: FP3 was potent as compare to standard glibenclamide (P < 0.05-0.001) and FP6, FP9, and FP4 were also effective as an antihyperglycemic agent. The activity profile of the molecule was as follows FP9< FP10< FP4< FP6<FP12< FP3. This study reflects that presence of para methoxy phenyl group linked with phenyl group in surface recognition portion and imidazolyl triazole group in linker portion associated with a sulfamethyl hydroxamic acid group in metal identifying the part in case of FP3 was resemble for antihyperglycemic activity.Conclusion: It was concluded that compounds possessing electron releasing groups on the aromatic rings in the surface recognition part considerably enhanced the antihyperglycemic activity.
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Geary, Brad, Jared Benson, Steven Wood, James Logan, Ben Brulotte, Alan Chambers, Jeff Maughan, and Mikel Stevens. "(223) Profiling of Physical and Molecular Characteristics in Neotyphodium Isolates." HortScience 41, no. 4 (July 2006): 1035B—1035. http://dx.doi.org/10.21273/hortsci.41.4.1035b.

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Endophytic fungi that are classified into the genus Neotyphodium have developed into a very unique niche. Their specific host plants are the fescues and ryegrasses. Through fungal biosynthesis of secondary metabolites, the host plant receives several benefits. These benefits include resistance to insects such as aphids, chinch bug, and argentine stem weevil, increased drought tolerance, and increased competiveness. These secondary metabolites comprise four groups of alkaloids. The alkaloids are loline, peramine, Lolitrem B, and ergovaline. The quantitative alkaloid profile is unique for each isolate. The characterization of these endophytes is necessary for identification of specific isolates. We report the characterization of ten endophytic strains Lp1, Lp2, Lp3, Lm4, Lm5, Fp6, Fp7 Fp8, Fp9, Fp10. The characterization of each isolate includes: morphology, sporulation, growth rates, microsatellite fingerprint, and alkaloid profile. The isolated colonies bear resemblance to raised brain-like structures and are yellow to tan in color. Growth rates range between 0.1 and 0.25 mm/day. No colonies produced any form of sporulation. Fp6 was found to have the highest loline concentration of any isolate. AFLP analysis was performed on the isolates to test for relatedness. Distinct clades were formed and grouped by host. The main groups were those isolated from Lolium or Festuca varieties. Isolates Fp8 and Fp9 were most related to each other, and have also been found to be doubly infected. The double infection is described to be Phialophora-like, due to the presence of thin highly branched hyphae when observed under light microscopy with aniline blue staining.
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Blanck-Lubarsch, Moritz, Dieter Dirksen, Reinhold Feldmann, Cristina Sauerland, and Ariane Hohoff. "Children with Fetal Alcohol Syndrome (FAS): 3D-Analysis of Palatal Depth and 3D-Metric Facial Length." International Journal of Environmental Research and Public Health 17, no. 1 (December 21, 2019): 95. http://dx.doi.org/10.3390/ijerph17010095.

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Background: Drinking alcohol during pregnancy can result in severe developmental disorders in the child. Symptoms of the fetal alcohol spectrum disorder (FASD) comprise growth deficiencies, abnormal facial phenotype and damage or dysfunction of the central nervous system. Numerous diagnostic methods for facial phenotyping in FASD exist, but diagnoses are still difficult. Our aim was to find additional and objective methods for the verification of FAS(D). Methods: Three-dimensional dental models of 60 children (30 FAS and 30 controls) were used to metrically determine maximum palatal depths at the median palatine raphe. Three-dimensional facial scans were taken, and vertical distances of the face were measured at five defined facial landmarks (FP1–FP5) for each child. Results: Mean palatal height, total facial length (FP1–FP5) as well as FP4–FP5 did not significantly differ between the FAS group and the control group. Comparing vertical facial subdivisions, however, resulted in significant differences for distances FP1 to FP2 (p = 0.042, FAS > controls), FP2 to FP3 (p < 0.001, FAS < controls), FP3 to FP4 (p < 0.001, FAS > controls) and FP3 to FP5 (p = 0.007, FAS > controls). Conclusions: Metric vertical measurements of the face can be used as additional objective criteria for FAS diagnoses. However, no significant differences were reported for palatal depth evaluation in the specific age range tested in the present study.
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López, Eulalio Morel, Derlys Fernando López Ávalos, Modesto Osmar Da silva, Amílcar Servín Niz, Oscar Caballero Casuriaga, Wilfrido Lugo Pereira, Florencio David Valdez, and Cayetano Marín Jara. "Fraccionamiento de potasio en épocas en variedades de soja / Fractionation of potassium in times in soybean varieties." Brazilian Journal of Animal and Environmental Research 5, no. 1 (March 14, 2022): 1123–32. http://dx.doi.org/10.34188/bjaerv5n1-085.

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El objetivo del estudio fue evaluar el efecto de aplicación de potasio fraccionada en épocas en las variedades de soja. El experimento fue realizado en el distrito de Concepción, Paraguay. Se utilizó un diseño en bloques completos al azar con parcela subdividida (2 x 6), la parcela principal correspondió a Variedad de soja (R19 y R24) y la parcela secundaria el fraccionamiento de potasio (FP1: 0 kg ha-1; FP2: 70 kg ha-1 en la siembra; FP3: 50 kg ha-1 en la siembra + 20 kg ha-1 en cobertura a los 30 DDE; FP4: 35 kg ha-1 en la siembra + 35 kg ha-1 en cobertura a los 30 DDE; FP5: 20 kg ha-1 en la siembra + 50 kg ha-1 en cobertura a los 30 DDE; FP6: 70 kg ha-1 en cobertura a los 30 DDE) con tres repeticiones. Se determinaron, altura de las plantas, altura de inserción de la primera vaina, diámetro de tallo, N° de vainas por planta, N° de granos por vaina, peso de 1000 granos y rendimiento. Los datos fueron sometidos a ANAVA, mediante el Test F y las medias comparadas entre sí por el Test de Tukey al 5%. Los resultados indican que, en las determinaciones de altura de inserción de la primera vaina, diámetro de tallo demuestran interacciones estadísticamente de los factores mientras el peso de 1000 granos y rendimiento fue afectado en ambos factores. Se concluye que la variedad de soja más sobresaliente fue la variedad R24, ya que alcanzó el mayor en peso de 1000 granos y rendimiento. La aplicación de dosis de potasio en fraccionamiento en cobertura, el más efectivo las dosis de 35 kg ha-1 en la siembra y 35 kg ha-1 en cobertura a los 30 DDE.
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Yamamura, Kentaro, Kohshi Ohishi, Naoyuki Katayama, Hiroshi Shiku, Mitsuo Nishikawa, and Tatsutoshi Nakahata. "Delta-1 Promotes Soluble IL-6R-Mediated Action of IL-6 on Human Erythropoiesis While Counteracting the Effect of IL-6 on the Generation of Myeloid-Lineage Cells." Blood 106, no. 11 (November 16, 2005): 3143. http://dx.doi.org/10.1182/blood.v106.11.3143.3143.

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Abstract Notch ligand Delta-1 is shown to influence proliferation and differentiation of hematopoietic progenitors by interacting with various cytokines. IL-6 exerts various effects on human hematopoiesis by activating gp130 via soluble IL-6 receptor (R) as well as membrane-bound IL-6R. However, little is known about the interaction between Delta-1 and gp130 activation in human hematopoiesis. We previously reported that Delta-1 in combination with IL-6R/IL-6 fusion protein FP6, which directly and agonistically activates gp130, enhances the production of mixed and pure erythroid progenitors from cord blood CD34+CD38− cells, while not significantly affecting the generation of myeloid progenitors (ASH 2004). Here, we examined the interaction between Delta-1 and gp130 activation in the generation of erythroid cells and myeloid-lineage cells from cord blood CD34+CD38− cells in serum-free suspension cultures. In the presence of SCF, Flt3L, TPO, and IL-3 (4GF), Delta-1 acted synergistically with FP6 to promote the production of CD36+glycophorin A (GPA)high erythroid cells from CD34+CD38− cells, whereas few CD36+GPAhigh erythroid cells were generated by Delta-1, IL-6, and Delta-1 plus IL-6. When we assessed the stage of erythroid cells affected by Delta-1 and FP6, Delta-1, in conjunction with FP6, augmented the generation of CD36+GPAhigh erythroid cells from CD34+CD38− cell-derived CD36+GPA− erythroid progenitors equivalent to BFU-E stage but not from CD34+CD38−cell-derived CD36+GPAlow erythroid progenitors equivalent to CFU-E stage. On the other hand, IL-6 and FP6 increased the production of CD14+ monocytic cells and CD15+ granulocytic cells from CD34+CD38− cells. Delta-1 had opposite effect and antagonized the stimulatory effect of IL-6 and FP6 on the generation of monocytic and granulocytic cells. Although the development of CD1a+CD14− dendritic cells from CD34+CD38− cells was suppressed by IL-6 and FP6 but instead potentiated by Delta-1, Delta-1 competed with the inhibitory effect of IL-6 and FP6 on the generation of dendritic cells. These data indicate that Delta-1 modulates the effect of IL-6 on human hematopoiesis by enhancing its soluble IL-6R-mediated action on early erythropoiesis while antagonizing its effect on the generation of myeloid-lineage cells.
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Calignano, Giuseppe, and Robert Hassink. "Increasing innovativeness of SMEs in peripheral areas through international networks? The case of Southern Italy." REGION 3, no. 1 (April 19, 2016): 25. http://dx.doi.org/10.18335/region.v3i1.93.

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Strengthening innovation capacity of European small and medium enterprises (SMEs) by means of their participation in the Sixth (FP6-SME) and Seventh (FP7-SME) Framework Programmes was an important objective of the European Union policies. Since SMEs form the backbone of the Italian economy, their strong presence in an international network such as the one fostered by the European Union represent a great opportunity, particularly for firms located in southern Italy – the marginal macro-area of the country in terms of innovation – to increase their competitiveness. Based on the major literature on topics such as knowledge exchange, innovation networks and disparities, and on descriptive statistics and a cluster analysis in a dynamic perspective, our study aimed to assess the actual intra-regional, extra-regional and transnational links established by the Italian SMEs and public research establishments (PREs). In a next step we aim at assessing if knowledge flows fostered by the FP6-SME and FP7-SME were mainly concentrated in the traditionally winning macro-regional areas (North and Centre) or led to more widespread benefits in favour of SMEs located in the marginal South. The findings of our study revealed a very limited number of connections - with a related weak knowledge exchange - involving the southern regions, implying a reinforcement of innovation activities in the traditionally most dynamic industrial areas of the country.
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Perks, Bea. "FP6 brings bigger funds and some confusion." Nature Medicine 8, no. 12 (December 2002): 1339. http://dx.doi.org/10.1038/nm1202-1339a.

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Beavis, Richard. "The EU FP6 CACHET project - Final results." Energy Procedia 4 (2011): 1074–81. http://dx.doi.org/10.1016/j.egypro.2011.01.157.

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Redaktion, TATuP. "Commission Conference to Mark Launch of FP6." TATuP - Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis 11, no. 1 (April 1, 2002): 161. http://dx.doi.org/10.14512/tatup.11.1.161.

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Butterworth, A. "EU FP6 Welfare Quality® Poultry Assessment Systems." Korean Journal of Poultry Science 36, no. 3 (September 30, 2009): 239–46. http://dx.doi.org/10.5536/kjps.2009.36.3.239.

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Uddin, MS, MM Rahman, MZ Alam, MM Hossain, and ME Hoque. "Effect of farmers' practices for the management of insect pests of yard long bean (Vigna unguiculata)." Bangladesh Journal of Agricultural Research 39, no. 1 (August 25, 2014): 173–84. http://dx.doi.org/10.3329/bjar.v39i1.20167.

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The research activity was conducted in major intensive yard long bean growing areas, such as Jessore, Dhaka, Narsingdi, Comilla, and Chittagong of Bangladesh to know farmers’ practices (FPs) for managing major insect pests of yard long bean during March 2009 to October 2009 in the farmers’ fields. The study comprised survey of sample farmers through intensive field visit for field data collection and inspection. A total of 5 farmers’ practices (FPs) were identified viz., Farmers’ Practice 1 (FP1) comprised chemicals plus mechanical plus cultural plus field sanitation, FP2 comprised chemicals plus cultural plus field sanitation, FP3 consisted of combination of chemicals plus field sanitation, FP4 having combination of mechanical plus cultural plus field sanitation and FP5 utilized combination of cultural plus field sanitation. Among the sample farmers, 81.33% practiced chemicals plus non-chemical methods, while 18.67% practiced only non-chemical methods. Considering infestation level, pod yield, BCR, and arthropod pests diversity, the performance of FP1 (chemical + mechanical + cultural + field sanitation methods) was adjudged as the best for managing pod borer and aphid and was revealed as the most suitable option (94.10% infestation reduction) for managing major insect pests of yard long bean in those areas of Bangladesh. DOI: http://dx.doi.org/10.3329/bjar.v39i1.20167 Bangladesh J. Agril. Res. 39(1): 173-184, March 2014
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Stainsby, Richard, Karen Peers, Colin Mitchell, Christian Poette, Konstantin Mikityuk, and Joe Somers. "Gas Cooled Fast Reactor Research and Development in the European Union." Science and Technology of Nuclear Installations 2009 (2009): 1–7. http://dx.doi.org/10.1155/2009/238624.

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Gas-cooled fast reactor (GFR) research is directed towards fulfilling the ambitious goals of Generation IV (Gen IV), that is, to develop a safe, sustainable, reliable, proliferation-resistant and economic nuclear energy system. The research is directed towards developing the GFR as an economic electricity generator, with good safety and sustainability characteristics. Fast reactors maximise the usefulness of uranium resources by breeding plutonium and can contribute to minimising both the quantity and radiotoxicity nuclear waste by actinide transmutation in a closed fuel cycle. Transmutation is particularly effective in the GFR core owing to its inherently hard neutron spectrum. Further, GFR is suitable for hydrogen production and process heat applications through its high core outlet temperature. As such GFR can inherit the non-electricity applications that will be developed for thermal high temperature reactors in a sustainable manner. The Euratom organisation provides a route by which researchers in all European states, and other non-European affiliates, can contribute to the Gen IV GFR system. This paper summarises the achievements of Euratom's research into the GFR system, starting with the 5th Framework programme (FP5) GCFR project in 2000, through FP6 (2005 to 2009) and looking ahead to the proposed activities within the 7th Framework Programme (FP7).
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Capone, Francesco. "Technological clusters and innovation trajectories in shipbuilding in Europe: An analysis of FP6 and FP7 European projects." Australian Journal of Maritime & Ocean Affairs 6, no. 2 (April 3, 2014): 89–105. http://dx.doi.org/10.1080/18366503.2014.915783.

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Forbes, Matt, Erick Bestland, and Rod Wells. "Preliminary 14C Dates on Bulk Soil Organic Matter from the Black Creek Megafauna Fossil Site, Rocky River, Kangaroo Island, South Australia." Radiocarbon 46, no. 1 (2004): 437–43. http://dx.doi.org/10.1017/s0033822200039746.

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Radiocarbon age determinations and stratigraphy suggest that the deposits in Black Creek Swamp on Kangaroo Island record 3 phases of deposition and associated soil development which spanned at least the last 20,000 yr. Four new 14C age determinations on bulk soil organic matter and their stratigraphic context are presented in this paper. Three of these age determinations (FP6: 15,687 ± 110 BP [WK11487]; FP7: 16,326 ± 385 BP [WK11488]; and FP8: 17,618 ± 447 BP [WK11489]), are from the organic-rich fossil layer located 45–75 cm below the current floodplain surface. The fourth, a much younger date, FP5: 5589 ± 259 BP (WK11486), was obtained from the base of the overlying modern soil. The dates for the fossil layer increase systematically with depth and correlate well with 5 previous 14C dates (Hope et al., unpublished), ranging between 15,040 ± 120 BP and 19,000 ± 310 BP. This suggests that the data set represents a possible minimum age of the bulk organic matter, and considering the high organic matter contents of approximately 8%, has implications for the age of the megafauna buried in this layer. The overlying modern soil, with its much younger date, contains lower levels of organic matter (3–7%) and gastropods not seen in the fossil layer. This suggests a substantial change in environmental conditions probably due to an alteration in the floodplain drainage conditions. This chronological and sedimentalogical discontinuity indicates that 2 distinct depositional regimes existed and were separated by up to 10,000 14C yr. A calcareous, sandy silt deposit underlying the fossil layer is a calcarenite deposit with low total organic content and is considered the base of the section; it suggests a third separate depositional episode. As such, the Black Creek Swamp in the southwest corner of Kangaroo Island formed intermittently over at least the last 20,000 yr during 3 distinct depositional phases, one of which was the formation of the fossil-laden, organic-rich floodplain surface, which has a possible minimum age of approximately 15,000 to 19,000 BP.
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Korotaev, G. K., V. L. Dorofeev, S. V. Motyzhev, V. N. Belokopytov, A. Palazov, V. Malciu, A. Zatsepin, et al. "Contribution of the Black Sea observing system to ECOOP." Ocean Science Discussions 8, no. 4 (July 11, 2011): 1695–722. http://dx.doi.org/10.5194/osd-8-1695-2011.

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Abstract. Regular observations in the Black Sea basin started in the past century, and quite good multidisciplinary observing system operated in the 70–80ies based on the ship observations. Modern oceanographic observing system in the basin is built according to the GOOS principles. It includes space remote sensing observations, data of free floating buoys and costal observational network. Integration of the observing system and its real-time operation were started within the framework of the FP5 ARENA project and later were improved during the FP6 ASCABOS project. The coastal observing system which includes time series from the coastal platforms and multidisciplinary surveys of the coastal areas fulfilled by the research vessels was set up during the ECOOP. Paper describes all components of the Black Sea observing system operated during the ECOOP project and its applications in the framework of the project.
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Neri, Fabio. "The e-Photon/ONe Network of Excellence in EC FP6." Annales Des Télécommunications 62, no. 5-6 (May 2007): 714–19. http://dx.doi.org/10.1007/bf03253285.

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Enghardt, Lars. "The EU FP6 research project PROBAND ‐ Objectives and first results." Journal of the Acoustical Society of America 123, no. 5 (May 2008): 3524. http://dx.doi.org/10.1121/1.2934460.

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d’Hugues, P., P. R. Norris, K. B. Hallberg, F. Sánchez, J. Langwaldt, A. Grotowski, T. Chmielewski, and S. Groudev. "Bioshale FP6 European project: Exploiting black shale ores using biotechnologies?" Minerals Engineering 21, no. 1 (January 2008): 111–20. http://dx.doi.org/10.1016/j.mineng.2007.10.004.

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bols, Ch-M. "From science to business: the FP6 “Sophied” project success story." Journal of Biotechnology 150 (November 2010): 57–58. http://dx.doi.org/10.1016/j.jbiotec.2010.08.151.

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Touzi, Ridha, Masanobu Shimada, and Takeshi Motohka. "Calibration and Validation of Polarimetric ALOS2-PALSAR2." Remote Sensing 14, no. 10 (May 20, 2022): 2452. http://dx.doi.org/10.3390/rs14102452.

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PALSAR2 polarimetric distortion matrix is measured using corner reflectors deployed in the Amazonian forest. The Amazonian forest near the geomagnetic equator provides ideal sites for the assessment of L-band PALSAR2 antenna parameters, at free Faraday rotation. Corner reflectors (CRs) deployed at free Faraday rotation provide accurate estimation of antenna cross-talks in contrast to the biased measurements obtained with CRs deployed at significant Faraday rotation. The extended Freeman–Van Zyl calibration method introduced and validated for ALOS-PALSAR calibration is used for the assessment of PALSAR-2 calibration parameters. Six datasets collected over the Amazonian rainforests (with CRs) are used to assess PALSAR-2 distortion matrix for five beams (FP6-3 to FP6-7) with incidence angle varying from 25° to 40°. It is shown that the PALSAR2 antenna is highly isolated with very low cross-talks (lower than −40 dB). Finally, the impact of a significant Faraday rotation on antenna cross-talk measurements using CR is discussed.
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Sarotto, Massimo. "On the allowed sub-criticality level of lead (-bismuth) cooled ADS: the EU FP6 EFIT and FP7 FASTEF cases." Annals of Nuclear Energy 102 (April 2017): 440–53. http://dx.doi.org/10.1016/j.anucene.2016.12.028.

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Paci, Sandro, and Jean-Pierre Van Dorsselaere. "Spreading of Excellence in SARNET Network on Severe Accidents: The Education and Training Programme." Science and Technology of Nuclear Installations 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/237371.

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The SARNET2 (severe accidents Research NETwork of Excellence) project started in April 2009 for 4 years in the 7th Framework Programme (FP7) of the European Commission (EC), following a similar first project in FP6. Forty-seven organisations from 24 countries network their capacities of research in the severe accident (SA) field inside SARNET to resolve the most important remaining uncertainties and safety issues on SA in water-cooled nuclear power plants (NPPs). The network includes a large majority of the European actors involved in SA research plus a few non-European relevant ones. The “Education and Training” programme in SARNET is a series of actions foreseen in this network for the “spreading of excellence.” It is focused on raising the competence level of Master and Ph.D. students and young researchers engaged in SA research and on organizing information/training courses for NPP staff or regulatory authorities (but also for researchers) interested in SA management procedures.
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Galsworthy, M. J., R. Irwin, K. Charlesworth, K. Ernst, D. Hristovski, M. Wismar, and M. McKee. "An analysis of subject areas and country participation for all health-related projects in the EU's FP5 and FP6 programmes." European Journal of Public Health 24, no. 3 (June 25, 2013): 514–20. http://dx.doi.org/10.1093/eurpub/ckt075.

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Anton, P. M., and C. A. Dennehy. "Mitigating functional performance decrement in cancer patients undergoing treatment." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 9105. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.9105.

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9105 Background: It is well-documented that treatment side-effects cause physical and psychosocial de-conditioning in cancer patient. Decrease in functional performance (FP), as measured by activities of daily living (ADL), is a major contributor to a decline in patient quality of life (QOL). Relatively little information is available on the effects of a specific exercise regimen targeting muscle groups/energy systems involved in FP. Methods: 30 male and female cancer patients receiving treatment were randomly assigned to either the experimental (EX) or control (C) groups. EX participated in two exercise sessions per week for 17 weeks. Sessions included a combination of aerobic, resistance, flexibility, and balance training. C did not participate in any structured exercise. Data were collected post-diagnosis (1), post- surgery (2), at 9 weeks post-diagnosis (3), and at 17 weeks post-diagnosis (4). Measurements included resting heart rate (RHR), fatigue, physical activity level (PA), QOL, and the FP tasks of: treadmill walking (TRED), stair climb/descent (STAIR), lifting/carrying (CARRY), sit to stand (STAND), and balance (REACH). Results: Factor analysis yielded four variables: FP1 = [(0.5 × TRED) - (0.5 × RHR)]; FP2 = [(STAIR) + (CARRY) + (STAND)]/3]; FP3 = [(0.333 × QOL) + (0.333 × PA) - (0.333 × FT)]; FP4 = REACH. Repeated-measures ANOVA with within-subjects contrasts detected significant differences between groups. No significant differences existed at 1 or from 1 to 2. Significant differences were found on all variables from 1 to 4, 1 to 3 and 3 to 4 (p < 0.001) (significant improvement for experimental group vs. significant decline for control group). Mean changes for the experimental vs. control groups from 1 to 4 are as follows: FP1 (+65.5 vs. -29.5); FP2 (-5.3 vs. +3.6); FP3 (+1.8 vs. -3.4); FP4 (+1.7 vs. -0.81). Conclusions: Specifically-designed exercise interventions promote positive adaptations that elicit significant improvement in ADL, QOL, and decrease fatigue. Prescriptive exercise is a viable therapy during treatment for mitigating side effects and avoiding de-conditioning. No significant financial relationships to disclose.
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et Al, Luis Monteiro Rodrigues. "Proceedings Book - IV CBIOS Seminar, 2020." Biomedical and Biopharmaceutical Research Journal 17, no. 2 (December 2020): 1–37. http://dx.doi.org/10.19277/bbr.17.2.246.

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CBIOS Science Seminar 2020 November 23rd 9:00-9:30 Welcome and Registration 9:30-10:00 Opening L. M. Rodrigues (CBIOS Director) 10:00-10:15 OC1: Sérgio Faloni de Andrade: “The potential of natural products to treat gastrointestinal inflammatory and ulcerative diseases” 10:15-10:30 OC2: Patrícia Rijo: “Abietane Diterpenoids from Plectranthus spp. as a new class of PKC modulators” 10:30-10:45 OC3: Nuno Saraiva: “Effect of TMBIM ion channels in Glioma Progression” 10:45-11:00 OC4: Catarina Pereira Leite: “On the path of innovative nanodelivery systems for cutaneous applications” 11:00-11:15 OC5: João Pedro Gregório: “Health services digitalization: the role of Design Science Methodologies” 11:15-11:30 OC6: Pedro Faísca: “Stereology in grading and prognosis of canine cutaneous mast cell tumors” Flash Oral Communications 11:30-11:35 FP1: Margarida Florindo: “Perfusion, Movement and Adaptive Responses” 11:35-11:40 FP2: Vera Isca: “Royleanone Diterpenoids from Plectranthus spp. as P-Glycoprotein Inhibitors” 11:40-11:45 FP3: Íris Guerreiro: “How can rocket salads stop cancer cells from moving?” 11:45-11:50 FP4: Ana Júlio: “Ionic Liquids: a technological approach to improve the performance of sustained drug delivery systems” 11:50-11:55 FP5: Emília Alves: “Assessment of the impact of kefir consumption on cutaneous health using an induced lesion model” 11:55-12:15 Pause / Posters* 12:15-12:30 Awards and Closing Session
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Matt, Mireille, Stéphane Robin, and Sandrine Wolff. "The influence of public programs on inter-firm R&D collaboration strategies: project-level evidence from EU FP5 and FP6." Journal of Technology Transfer 37, no. 6 (September 15, 2011): 885–916. http://dx.doi.org/10.1007/s10961-011-9232-9.

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Potop, Vera, Constanta Boroneant, and Mihaela Caian. "Assessing the changes in drought conditions during summer in the Republic of Moldova based on RegCM simulations." Journal of Economic Development, Environment and People 2, no. 3 (September 30, 2013): 63. http://dx.doi.org/10.26458/jedep.v2i3.44.

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We assess the changes in drought conditions during summer in the Republic of Moldova based on the Standardized Precipitation Index (SPI) calculated from monthly precipitation data simulated by the regional climatic model RegCM3. The RegCM simulations were conducted at a horizontal resolution of 10 km in the framework of EU-FP6 project -CECILIA. The domain was centered over Romania at 46°N, 25°E and included the Republic of Moldova.
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28

Zhang, Shu-Dong, Joshua L. Smalley, Laura Suter-Dick, and Timothy W. Gant. "Connectivity Mapping for Early Toxicity Recognition Using the FP6 InnoMed PredTox Data." Toxicology 262, no. 1 (July 2009): 7. http://dx.doi.org/10.1016/j.tox.2009.04.052.

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Delger, Patti, Bryan Bauer, and Tiffany Morgan. "FP6 Supporting Healthy Habits in Childcare with Online Trainings for CACFP Participants." Journal of Nutrition Education and Behavior 51, no. 7 (July 2019): S27. http://dx.doi.org/10.1016/j.jneb.2019.05.367.

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30

Yokoyama, Yasuhisa, Takahiro Suzuki, Mamiko Sakata-Yanagimoto, Keiki Kumano, Katsumi Higashi, Tsuyoshi Takato, Mineo Kurokawa, Seishi Ogawa, and Shigeru Chiba. "Derivation of functional mature neutrophils from human embryonic stem cells." Blood 113, no. 26 (June 25, 2009): 6584–92. http://dx.doi.org/10.1182/blood-2008-06-160838.

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Abstract Human embryonic stem cells (hESCs) proliferate infinitely and are pluripotent. Only a few reports, however, describe specific and efficient methods to induce hESCs to differentiate into mature blood cells. It is important to determine whether and how these cells, once generated, behave similarly with their in vivo–produced counterparts. We developed a method to induce hESCs to differentiate into mature neutrophils. Embryoid bodies were formed with bone morphogenic protein-4, stem cell factor (SCF), Flt-3 ligand (FL), interleukin-6 (IL-6)/IL-6 receptor fusion protein (FP6), and thrombopoietin (TPO). Cells derived from the embryoid bodies were cultured on a layer of irradiated OP9 cells with a combination of SCF, FL, FP6, IL-3, and TPO, which was later changed to granulocyte–colony-stimulating factor. Morphologically mature neutrophils were obtained in approximately 2 weeks with a purity and efficiency sufficient for functional analyses. The population of predominantly mature neutrophils (hESC-Neu's) showed superoxide production, phagocytosis, bactericidal activity, and chemotaxis similar to peripheral blood neutrophils from healthy subjects, although there were differences in the surface antigen expression patterns, such as decreased CD16 expression and aberrant CD64 and CD14 expression in hESC-Neu's. Thus, this is the first description of a detailed functional analysis of mature hESC-derived neutrophils.
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Klitkou, Antje, Arne Martin Fevolden, and Allan Dahl Andersen. "EU R&D Funding for Electricity Grid Technologies and the Energy Transition: Centralised versus Decentralised Transition Pathways." Energies 15, no. 3 (January 25, 2022): 868. http://dx.doi.org/10.3390/en15030868.

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In the acceleration phase transitions often increase in depth and scope, and thereby create knock-on effects for wider system structures. In the renewable energy transition, for example, higher shares of intermittent renewable energy sources call for new grid technologies to increase flexible grid operation. At the same time, there are different ways of achieving renewable energy transitions and providing flexibility. In Europe, important tensions exist over how centralised or decentralised a renewable energy electricity system should be. This paper explores to what extent and how European framework programmes for research and development have addressed and supported innovation in transmission grid (centralised system) and distribution grid (decentralised) technologies. We analyse European R&D projects that studied electricity grid planning, development and innovation over 2002–2020. We apply social network analysis of the collaboration partners in these projects, and analyse the calls for proposals issued by three European Framework Programmes: FP6, FP7 and Horizon 2020. The framework programmes have addressed energy-related issues, but the priorities have changed over time, reflecting the ongoing energy transition. We ask if the importance of transmission grid vs. distribution grid has changed over time, and if and how the collaboration patterns have changed.
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Rosenhahn, Axel, Thomas Ederth, and Michala E. Pettitt. "Advanced nanostructures for the control of biofouling: The FP6 EU Integrated Project AMBIO." Biointerphases 3, no. 1 (March 2008): IR1—IR5. http://dx.doi.org/10.1116/1.2844718.

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33

Tencer, Bárbara, Matilde Rusticucci, Phil Jones, and David Lister. "A Southeastern South American Daily Gridded Dataset of Observed Surface Minimum and Maximum Temperature for 1961–2000." Bulletin of the American Meteorological Society 92, no. 10 (October 1, 2011): 1339–46. http://dx.doi.org/10.1175/2011bams3148.1.

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This study presents a southeastern South American gridded dataset of daily minimum and maximum surface temperatures for 1961–2000. The data used for the gridding are observed daily data from meteorological stations in Argentina, Brazil, Paraguay, and Uruguay from the database of the European Community's Sixth Framework Programme A Europe–South America Network for Climate Change Assessment and Impact Studies in La Plata Basin (EU FP6 CLARIS LPB), with some additional data series. This gridded dataset is new for the region, not only for its spatial and temporal extension, but also for its temporal resolution. The region for which the gridded dataset has been developed is 20°–40°S, 45°–70°W, with a resolution of 0.5° latitude × 0.5° longitude. Since the methodology used produces an estimation of gridbox averages, the developed dataset is very useful for the validation of regional climate models. The comparison of gridded and observed data provides an evaluation of the usefulness of the interpolated data. According to monthly-mean values and daily variability, the methodology of interpolation developed during the EU FP6 ENSEMBLE-based predictions of climate changes and their impacts (ENSEMBLES) project for its application in Europe is also suitable for southeastern South America. Root-mean-square errors for the whole region are 1.77°C for minimum temperature and 1.13°C for maximum temperature. These errors are comparable to values obtained for Europe with the same methodology.
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Wiesenfeld, Laurent, Alexandre Faure, Nicolas Troscompt, Michael Wernli, Cecilia Ceccarelli, and Pierre Valiron. "Molecular collisions : State-of-the-art calculations of inelastic collisions." Proceedings of the International Astronomical Union 4, S251 (February 2008): 141–42. http://dx.doi.org/10.1017/s174392130802139x.

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AbstractWe set up a framework for calculating in a precise and controlled way the collisional properties of several molecules of astrophysical meaning. The quantities that are relevant for astrophysics are rotational and vibrational quenching/excitation rates by means of collisions of H2 with water and some organic molecules (HC3N, H2CO). We calculate those rates by means of successively determining a intermolecular potential energy surface and calculating inelastic cross sections and rates classically and/or quantum mechanically. These calculations are part of the European Union FP6 Molecular Universe program.
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35

Sipaúba-Tavares, LH, LM Seto, and RN Millan. "Seasonal variation of biotic and abiotic parameters in parallel neotropical fishponds." Brazilian Journal of Biology 74, no. 1 (February 2014): 166–74. http://dx.doi.org/10.1590/1519-6984.22712.

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The present study was carried out to evaluate the phytoplankton community and water quality in four parallel fishponds (FP1 to FP4) during one year. Some abiotic parameters of water column and phytoplankton was sampled in four sites, one in each fishpond. Similarity analysis showed that FP2 fishpond was markedly different for the others ponds with regard to phytoplankton community. Conductivity, orthophosphate, temperature, TSS and hardness parameters were significantly different (p<0.05) between fishponds and all limnological parameters were significantly different (p<0.01) among period (months). Organic matter and phosphorus of the sediment were significantly different (p<0.01) only among fishponds. In current study Chlorophyceae and Bacillariophyceae occurred in most months. Cyanobacteria density in April and May was higher in all fishponds, at FP3 represented 71.4% in April and FP1 represented 78.7% in May of total reported, with chlorophyll-a content lower than 41 mg.L−1. The physical and chemical parameters of fishponds water constituted relations between the parameters and algae occurrence. The present study however, indicated that Cyanobacteria was more frequent in the fishponds after the fish grow-out period (April), and the water quality should be monitored more frequently in this period, due to the high total phosphorus, orthophosphate and chlorophyll-acontents.
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36

D'HUGUES, P., P. SPOLAORE, and Bioshale Consortium. "Biohydrometallurgy applied to exploitation of black shale resources: Overview of Bioshale FP6 European project." Transactions of Nonferrous Metals Society of China 18, no. 6 (December 2008): 1485–90. http://dx.doi.org/10.1016/s1003-6326(09)60030-3.

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37

Kumari*, D., R. Sridhara, N. Arora, S. N. Gaur, and B. P. Singh. "PULSES AS A CAUSATIVE FACTOR IN SENSITIZATION OF PATIENTS WITH ASTHMA AND RHINITIS. - FP6." Annals of Allergy, Asthma & Immunology 93, no. 5 (November 2004): S54. http://dx.doi.org/10.1016/s1081-1206(10)61743-7.

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38

Romaniuk, Ryszard S. "ARIES – Development of Accelerator Technology in Europe 2017-2020: Global and Local Consequences." International Journal of Electronics and Telecommunications 63, no. 1 (March 1, 2017): 109–17. http://dx.doi.org/10.1515/eletel-2017-0015.

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Abstract The article describes chosen, yet key parts of newly established European, infrastructural research and development project ARIES (2017-2020) - Accelerator Research and Innovation for European Science and Society, to be realized inside the framework of the H2020 programme. Two institutions from Poland participate in ARIES – these are Warsaw University of Technology and Institute of Nuclear Chemistry and Technology. ARIES is a topical continuation of the previous infrastructural accelerator projects realized uninterruptedly since 2003 – FP6 CARE – Coordinated Accelerator Research in Europe and FP7 TIARA – Test Infrastructure and Accelerator Research Area, EuCARD – European Coordination for Accelerator Research and Development, and EuCARD2. The article is simultaneously a part of a series of papers concerning the participation of Polish doctoral students and young researchers, especially from the Warsaw University of Technology, in large European and world experiments of the discovery class, including building large research infrastructures like: FLASH and EXFEL, ESS, ITER and DEMO, IFMIF, but also satellites built by the ESA, etc. ARIES embraces, among others, the following subjects: energy efficiency and management, cost lowering, miniaturization and ultra-high field gradients, promotion innovation, industrial applications, societal implications, new materials and components, new methods of particles acceleration including laser-plasma-particles interaction, and building new generations of systems.
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39

Van Dorsselaere, Jean-Pierre, Ari Auvinen, David Beraha, Patrick Chatelard, Christophe Journeau, Ivo Kljenak, Alexei Miassoedov, Sandro Paci, Th Walter Tromm, and Roland Zeyen. "The European Research on Severe Accidents in Generation-II and -III Nuclear Power Plants." Science and Technology of Nuclear Installations 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/686945.

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Forty-three organisations from 22 countries network their capacities of research in SARNET (Severe Accident Research NETwork of excellence) to resolve the most important remaining uncertainties and safety issues on severe accidents in existing and future water-cooled nuclear power plants (NPP). After a first project in the 6th Framework Programme (FP6) of the European Commission, the SARNET2 project, coordinated by IRSN, started in April 2009 for 4 years in the FP7 frame. After 2,5 years, some main outcomes of joint research (modelling and experiments) by the network members on the highest priority issues are presented: in-vessel degraded core coolability, molten-corium-concrete-interaction, containment phenomena (water spray, hydrogen combustion…), source term issues (mainly iodine behaviour). The ASTEC integral computer code, jointly developed by IRSN and GRS to predict the NPP SA behaviour, capitalizes in terms of models the knowledge produced in the network: a few validation results are presented. For dissemination of knowledge, an educational 1-week course was organized for young researchers or students in January 2011, and a two-day course is planned mid-2012 for senior staff. Mobility of young researchers or students between the European partners is being promoted. The ERMSAR conference is becoming the major worldwide conference on SA research.
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Pavlov, Igor' Nikolayevich, Yuliya Aleksandrovna Litovka, Ekaterina Alekseyevna Litvinova, Stefaniya Mikhaylovna Petrenko, and Rustam Khamidzhanovich Enazarov. "PROSPECTS FOR DEEP CULTIVATION OF FOMITOPSIS PINICOLA (SW.) P. KARST. ON HYDRODYNAMIC AC-TIVATED PLANT WASTE." chemistry of plant raw material, no. 4 (December 21, 2020): 385–94. http://dx.doi.org/10.14258/jcprm.2020048400.

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The results of solid-phase and deep cultivation of the Siberian strain Fp6-17 Fomitopsis pinicola (Sw.) P. Karst. are presented. Growth parameters were determined on cellulose-containing agarized media and plant substrates with the addition of a solid phase after hydrodynamic activation of fir needles and sawdust of birch. Radial growth rate 3.0–4.3 mm / day; growth coefficient 37–64. Changes in polysaccharides in activated birch sawdust during fermentation noted, despite the low growth coefficient of the fungus. After hydrodynamic activation, the content of easily hydrolysable polysaccharides increased by 9 %, the proportion of hardly hydrolysable polysaccharides decreased by 8%. After further solid-phase cultivation, the content of easily and hardly hydrolysable polysaccharides decreased by 10 and 23%, respectively. The conditions for the deep cultivation of the strain Fp6-17 on a modified Norkrans medium with microcrystalline cellulose selected. At 26 °C and a pH of 4.6 on the seventh day, the maximum activity of carboxymethyl cellulase was 13.6 units / ml; biomass yield – 16.2 g/l. The optimal composition of the solid phase medium was selected after hydrodynamic processing of fir needles and sawdust of birch with enrichment of (NH4)2SO4. The maximum activity of the enzyme was 14.2 u/ml. With high enzymatic activity in the culture fluid, the formation of small globules with a diameter of up to 5 mm and a smaller amount of biomass is noted. At lower enzyme indices, in most cases a greater increase in biomass recorded due to the formation of large ellipsoid pellets with a fringed edge.
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41

Maggioni, Mario A., Teodora Erika Uberti, and Mario Nosvelli. "The "Political" Geography of Research Networks." International Regional Science Review 40, no. 4 (December 9, 2015): 337–76. http://dx.doi.org/10.1177/0160017615614896.

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The production of scientific and technical knowledge is mostly concentrated in specific locations. Knowledge flows very easily within regions; however, scientific and technical knowledge does flow also between different regions. The aim of this article is to analyze knowledge flows between agglomerations of innovative inputs, and their effects on the innovative performance of regions. We estimate a regional knowledge production function and we test, through appropriate spatial econometric estimation techniques, the effect of both geographical and relational autocorrelation (as measured by participation to joint research networks in the European Union [EU] Sixth Framework Programme [FP6]). We adopt two selection criteria in order to define different relational “geographies” (hence spatial weights matrices), and we model the unobservable structure and link value of knowledge flows within these joint research networks. Our results confirm established evidence that knowledge flows within interregional research networks along a top-down nonsymmetrical and hierarchical structure. However, the EU enlargement - and a modified structure of incentive for collaboration activity of European institutions- changed the direction of knowledge flows toward a top-down dynamics of knowledge diffusion from coordinator to participants for “EASTWARD” research networks (whose coordinator is in the west and most participants in the east); while the contrary (a hierarchical bottom-up dynamic of knowledge transfer) is true for WESTWARD networks (whose coordinator is in the east and most participants in the west). FP6 is therefore a platform for knowledge barter exchange for EU15, while works as a mere one-way channel for knowledge diffusion from EU15 toward Central and Eastern European countries.
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42

Hunter, Peter, Tara Chapman, Peter V. Coveney, Bernard de Bono, Vanessa Diaz, John Fenner, Alejandro F. Frangi, et al. "A vision and strategy for the virtual physiological human: 2012 update." Interface Focus 3, no. 2 (April 6, 2013): 20130004. http://dx.doi.org/10.1098/rsfs.2013.0004.

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European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368 , 2595–2614 ( doi:10.1098/rsta.2010.0048 )). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al. : (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.
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43

Kubryakov, A. I., G. K. Korotaev, V. L. Dorofeyev, Yu B. Ratner, A. Palazov, N. Valchev, V. Malciu, R. Matescu, and T. Oguz. "Black Sea coastal forecasting systems." Ocean Science Discussions 8, no. 3 (May 10, 2011): 1055–88. http://dx.doi.org/10.5194/osd-8-1055-2011.

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Abstract. The Black Sea coastal nowcasting and forecasting system was built within the framework of EU FP6 ECOOP project for five regions: the south-western basin along the coasts of Bulgaria and Turkey, the North-Western shelf along the Romanian and Ukrainian coasts, coastal zone around of the Crimea peninsula, the north-eastern Russian coastal zone and the coastal zone of Georgia. The system operates in the real-time mode during the ECOOP project and afterwards. The forecasts include temperature, salinity and current velocity fields. Ecosystem model operates in the off-line mode near the Crimea coast.
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44

McBRIDE, CONOR, and TARMO UUSTALU. "Preface." Journal of Functional Programming 19, no. 3-4 (July 2009): 263–64. http://dx.doi.org/10.1017/s0956796809007242.

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This special issue of the Journal of Functional Programming collects revised selected articles arising from the inaugural meeting of the Workshop on Mathematically Structured Functional Programming, MSFP 2006, held in Kuressaare, Estonia, on 2 July 2006, with support from the European Union's FP6 IST Coordination Action TYPES. This workshop raised the curtain for the Eighth International Conference on Mathematics of Program Construction, MPC 2006, but where MPC is concerned primarily with extrinsic mathematics supporting the programming process, MSFP has a complementary focus on the mathematics intrinsic to programs themselves. MSFP is about the extraction of functionality from structure.
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45

Denby, Bruce, Steinar Larssen, Peter Builtjes, Menno Keuken, Ranjeet Sokhi, Nicolas Moussiopoulos, John Douros, Carlos Borrego, Ana Margarida Costa, and Thomas Pregger. "Recommendations for the spatial assessment of air quality resulting from the FP6 EU project Air4EU." International Journal of Environment and Pollution 44, no. 1/2/3/4 (2011): 128. http://dx.doi.org/10.1504/ijep.2011.038411.

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46

Brenner, W., A. Almansa-Martin, and F. Sümecz. "Advanced methods and tools for handling and assembly in microtechnology – A European approach in FP6." Microelectronic Engineering 83, no. 4-9 (April 2006): 1386–88. http://dx.doi.org/10.1016/j.mee.2006.01.060.

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47

Villarejo-Carballido, Beatriz, Cristina Pulido, Lena de Botton, and Olga Serradell. "Dialogic Model of Prevention and Resolution of Conflicts: Evidence of the Success of Cyberbullying Prevention in a Primary School in Catalonia." International Journal of Environmental Research and Public Health 16, no. 6 (March 14, 2019): 918. http://dx.doi.org/10.3390/ijerph16060918.

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This article analyses the evidence obtained from the application of the dialogic model of prevention and resolution of conflicts to eradicate cyberbullying behaviour in a primary school in Catalonia. The Dialogic Prevention Model is one of the successful educational actions identified by INCLUD-ED (FP6 research project). This case study, based on communicative methodology, includes the results obtained from documentary analysis, communicative observations and in-depth interviews. The evidence collected indicates that the implementation of this type of model can help to overcome cyberbullying; children are more confident to reject violence, students support the victims more and the whole community is involved in Zero Tolerance to violence.
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48

Kubryakov, A. I., G. K. Korotaev, V. L. Dorofeev, Y. B. Ratner, A. Palazov, N. Valchev, V. Malciu, R. Mateescu, and T. Oguz. "Black Sea coastal forecasting system." Ocean Science 8, no. 2 (March 14, 2012): 183–96. http://dx.doi.org/10.5194/os-8-183-2012.

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Abstract. The Black Sea coastal nowcasting and forecasting system was built within the framework of EU FP6 ECOOP (European COastalshelf sea OPerational observing and forecasting system) project for five regions: the south-western basin along the coasts of Bulgaria and Turkey, the north-western shelf along the Romanian and Ukrainian coasts, coastal zone around of the Crimea peninsula, the north-eastern Russian coastal zone and the coastal zone of Georgia. The system operates in the real-time mode during the ECOOP project and afterwards. The forecasts include temperature, salinity and current velocity fields. Ecosystem model operates in the off-line mode near the Crimea coast.
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49

Deidda, R., M. Marrocu, G. Caroletti, G. Pusceddu, A. Langousis, V. Lucarini, M. Puliga, and A. Speranza. "Regional climate models' performance in representing precipitation and temperature over selected Mediterranean areas." Hydrology and Earth System Sciences 17, no. 12 (December 12, 2013): 5041–59. http://dx.doi.org/10.5194/hess-17-5041-2013.

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Abstract. This paper discusses the relative performance of several climate models in providing reliable forcing for hydrological modeling in six representative catchments in the Mediterranean region. We consider 14 Regional Climate Models (RCMs), from the EU-FP6 ENSEMBLES project, run for the A1B emission scenario on a common 0.22° (about 24 km) rotated grid over Europe and the Mediterranean region. In the validation period (1951 to 2010) we consider daily precipitation and surface temperatures from the observed data fields (E-OBS) data set, available from the ENSEMBLES project and the data providers in the ECA&amp;D project. Our primary objective is to rank the 14 RCMs for each catchment and select the four best-performing ones to use as common forcing for hydrological models in the six Mediterranean basins considered in the EU-FP7 CLIMB project. Using a common suite of four RCMs for all studied catchments reduces the (epistemic) uncertainty when evaluating trends and climate change impacts in the 21st century. We present and discuss the validation setting, as well as the obtained results and, in some detail, the difficulties we experienced when processing the data. In doing so we also provide useful information and advice for researchers not directly involved in climate modeling, but interested in the use of climate model outputs for hydrological modeling and, more generally, climate change impact studies in the Mediterranean region.
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Deidda, R., M. Marrocu, G. Caroletti, G. Pusceddu, A. Langousis, V. Lucarini, M. Puliga, and A. Speranza. "Climate model validation and selection for hydrological applications in representative Mediterranean catchments." Hydrology and Earth System Sciences Discussions 10, no. 7 (July 11, 2013): 9105–45. http://dx.doi.org/10.5194/hessd-10-9105-2013.

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Abstract. This paper discusses the relative performance of several climate models in providing reliable forcing for hydrological modeling in six representative catchments in the Mediterranean region. We consider 14 Regional Climate Models (RCMs), from the EU-FP6 ENSEMBLES project, run for the A1B emission scenario on a common 0.22-degree (about 24 km) rotated grid over Europe and the Mediterranean. In the validation period (1951 to 2010) we consider daily precipitation and surface temperatures from the E-OBS dataset, available from the ENSEMBLES project and the data providers in the ECA&amp;D project. Our primary objective is to rank the 14 RCMs for each catchment and select the four best performing ones to use as common forcing for hydrological models in the six Mediterranean basins considered in the EU-FP7 CLIMB project. Using a common suite of 4 RCMs for all studied catchments reduces the (epistemic) uncertainty when evaluating trends and climate change impacts in the XXI century. We present and discuss the validation setting, as well as the obtained results and, to some detail, the difficulties we experienced when processing the data. In doing so we also provide useful information and hint for an audience of researchers not directly involved in climate modeling, but interested in the use of climate model outputs for hydrological modeling and, more in general, climate change impact studies in the Mediterranean.
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