Dissertations / Theses on the topic 'Food-related quality of life'
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Mackenzie, Heather Elizabeth. "Measuring the health-related quality of life of teenagers with food-hypersensitivity." Thesis, University of Portsmouth, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500343.
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A disease-specific HRQL measure is essential to evaluate the impact of interventions on the HRQL of teenagers with FHS, who are coping with increasing responsibility for their FHS. However, there is no such measure for teenagers with FHS living in the UK. Hence, the aims of this research were to (i) describe the personal experiences of teenagers with FHS (ii) develop a disease-specific HRQL measure for this group and (iii) evaluate the reliability and validity of the HRQL measure.
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Leander, Mai. "Health-Related Quality of Life in Asthma." Doctoral thesis, Uppsala universitet, Arbets- och miljömedicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129626.
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Health-related quality of life (HRQL) has become an important outcome in asthma, since traditional outcomes, such as respiratory symptoms and pulmonary function, might not entirely express the patient’s perception of the limitations caused by the disease. The aim of this thesis was to study HRQL in asthma and to analyse if HRQL was related to asthma onset and prognosis. Other aims were to identify determinants of low HRQL in clinically-verified asthmatics, and to study whether low HRQL was a predictor of mortality. In 1990, a self-administered questionnaire was completed by 12,560 individuals from three age groups (16, 30-39, and 60-69 years) in two counties of Sweden. In a second phase, all subjects who reported a history of obstructive respiratory symptoms (n = 1,851) and 600 randomly-selected controls were invited to a clinical investigation including spirometry, allergy testing, and assessment of HRQL with the Gothenburg Quality of Life instrument. In 2003, the eligible subjects in the cohort (n=11,282) were sent a new questionnaire. Mortality data in the cohort was followed up during 1990–2008 using data from the National Board of Health and Welfare Mortality Database. The 616 subjects with clinically-verified asthma 1990 had significantly lower HRQL than subjects without asthma. In the 2003 follow-up, the 305 subjects with persistent asthma had a lower HRQL than the 155 subjects who showed improvement in asthma during the follow-up. Subjects who had developed asthma by the follow-up had a significantly lower HRQL at baseline than those who did not develop asthma. Significant determinants of quality of life in asthma were female sex, smoking habits, higher airway responsiveness to irritants, respiratory symptom severity, positive skin prick test, and absenteeism from work or school. Low HRQL was related to increased mortality, but this association was not found when analyzing the asthmatic group alone. In conclusion, measurements of HRQL are of value for evaluating both the impact and progression of asthma.
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Zhu, Haiwei. "Oral health-related quality of life after stroke." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37922567.
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Beeken, Rebecca J. "Health-related quality of life and response shift." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521916.
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Zhu, Haiwei, and 竺海瑋. "Oral health-related quality of life after stroke." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37922567.
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Huang, Wenwei, and 黄文伟. "Sub-health and health-related quality of life." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B49858713.
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Sub-health has been used to describe an intermediate state between health and disease. The impact of SH on HRQOL deserves more attention because HRQOL is an important goal of health care, and a significant determinant of health service utilization.
The aim of this study was to establish the epidemiology of Sub-health and explore the relationship between SH and HRQOL. Two studies were conducted in Hong Kong.
The first study was to develop and validate a Sub-health questionnaire (SHQ) for classifying people into Health, SH & Disease. The standard 7-step method of development of a psychometric measure was used to develop the SHQ. The initial SHQ, was then field tested on a sample of 13 Chinese adults. Pilot testing of the final version was conducted on 55 Chinese adults to confirm. Psychometric testing by a longitudinal survey on 353 Chinese adults who completed the SHQ, the SF-12v2 Health Survey and a structured questionnaire on sociodemographic data, and health service utilization at baseline, 2 to 4 weeks and 3-month. All HS items had Content Validity Index (CVI) on clarity and relevance of > 75%. The HS items demonstrated good internal consistency (Cronbach’s alpha=0.82). The overall test-retest reliabilities of classification of the health state were moderate with Kappa > 0.57. The SHQ was responsive in detecting a change in health states in 36.4% subjects in 3 months. Item scores of HS scales had significant correlation (r>0.4) with corresponding SF-12v2 scores, and there were significant differences in SF-12v2 summary scores between SHQ groups.
The second was a longitudinal study on Sub-health and HRQOL of general population to evaluate the validity and psychometric property of SHQ, to establish determine the epidemiology SH, and to explore the relationship between HRQOL of SH. 1231 Chinese adults were randomly selected from the general population by telephone survey with the SHQ, SF-12 Health Survey and a structured questionnaire on demographics and service utilization. 353 subjects had completed 3 to 12 months follow up surveys. The prevalence of Sub-health is 40.67% in Hong Kong. There were significant differences in SF-12v2 scores in that SH group had higher scores than those of disease group but lower scores than those of health group. SH was associated with higher use of medical resources than health.
Conclusively, the SHQ is a useful screening tool for the diagnosis of SH. There is a linear relationship between change in health status and changes in HRQOL or health service utilizations. It preliminary explored the clinical relevance of the SH to a culture and health care system that is different from that of mainland China where the concept originated. The results would be useful in populations worldwide if the SHQ could be cross-culturally adapted to identify the SH epidemiology. The study has also, provided evidence supporting the conceptual base of SH in the Chinese medicine context, which may be modifiable by treatment based on TCM Body Constitution classification.published_or_final_version
Family Medicine and Primary Care
Doctoral
Doctor of Philosophy
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John, Mike Torsten. "Oral health-related quality of life in Germany /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/10866.
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Dunderdale, Karen. "Health-related quality of life in chronic heart failure : development and validation of a patient-centred health-related quality of life measure." Thesis, University of York, 2007. http://etheses.whiterose.ac.uk/9910/.
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Garin, Boronat Olatz 1979. "Measuring health related quality of life in heart failure." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/123573.
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L’objectiu global d’aquesta tesis doctoral va ser identificar les fortaleses i limitacions de les mesures de Qualitat de Vida Relacionada amb la Salut desenvolupades específicament per pacients amb insuficiència cardíaca. Una revisió sistemàtica va trobar 7 qüestionaris de Qualitat de Vida Relacionada amb la Salut específics per insuficiència cardíaca: Chronic Heart Failure Assessment Tool (CHAT), Cardiac Health Profile congestive heart failure (CHPchf), Kansas City Cardiomyopathy questionnaire (KCCQ), Left Ventricular Disease Questionnaire (LVDQ), Minnesota Living with Heart Failure questionnaire (MLHFQ), i Quality of Life in Severe Heart Failure Questionnaire (QLSHFQ). L’evidència publicada fins 2006 senyalava el MLHFQ com el qüestionari més estès i recomanable. La versió espanyola del MLHFQ va mostrar característiques similars a l’original, així com també l’avaluació conjunta de versions de 20 països. A més, l’avaluació del model de mesura va confirmar la unidimensionalitat de la puntuació total del MLHFQ, i les seves dimensions física, emocional i social. L’actualització al 2011 de la revisió sistemàtica juntament amb l’avaluació estandarditzada per experts, varen destacar les propietats mètriques del KCCQ per sobre de les del MLHFQ.
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Gustafsson, Erik, and Fredrik Larsson. "Översättning och validering av Voice-Related Quality of Life." Thesis, Linköpings universitet, Logopedi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77932.
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En röststörning kan sägas föreligga då rösten inte fungerar eller låter som den brukar så att det påverkar kommunikationen. Prevalensen för röststörningar uppskattas till omkring 6 % av den vuxna befolkningen. När rösten inte fungerar som den ska leder det till emotionella, sociala och funktionella svårigheter för individen och har negativ inverkan på livskvaliteten. Voice- Related Quality of Life (V-RQOL) är ett självskattningsformulär som mäter vilken inverkan en röststörning kan ha på individens livskvalitet. Detta instrument är internationellt välanvänt, men har inte funnits översatt till svenska. Syftet med föreliggande uppsats var att översätta och validera V-RQOL för en svensk population. Översättningen skedde genom så kallad back translation och den svenska versionen fick namnet Röstrelaterad livskvalitet (RRL). RRL och Rösthandikappindex (RHI) distribuerades i pappersformat till en röstpatientgrupp (n = 88) och en röstfrisk grupp (n = 110). Reliabiliteten av domänerna och samtliga tio påståenden på RRL var hög för patientgruppen med Cronbach’s alfa- värden från 0.82 till 0.90. Det fanns en tydlig relation mellan den självskattade röstkvaliteten och poängen på RRL och formuläret kunde även differentiera mellan röstpatienter och röstfriska. Dessa resultat indikerar att formulärets begreppsvaliditet är god. Pearson’s korrelationsanalys visade att det fanns en signifikant negativ korrelation mellan RRL:s och RHI:s domäner och totalpoäng. Detta starka samband mellan ”the gold standard”, RHI, och RRL innebär en god kriterierelaterad validitet för formuläret. Sammanfattningsvis visar resultaten att RRL har hög reliabilitet och god validitet, dessutom är formuläret kort vilket innebär en liten arbetsinsats. Formuläret anses därför vara ett pålitligt och värdefullt tillägg i den kliniska bedömningen av röststörningar.A voice disorder can be said to exist when the voice does not work or sound as it normally should in a manner so that it interferes with communication. The prevalence of voice disorders is estimated to be about 6 % of the adult population. When the voice does not work as it should it may lead to emotional, social and functional difficulties for the individual and with negative effects on the quality of life. Voice- Related Quality of Life (V-RQOL) is a self-reporting questionnaire which measures the effect of a voice disorder on the quality of life of an individual. The instrument is frequently used internationally, but no Swedish translation has existed. In the present study, the purpose was to translate and validate V-RQOL for a Swedish population. The method for translating the questionnaire was back translation. The translated questionnaire was given the Swedish name Röstrelaterad livskvalitet (RRL). RRL and the Swedish version of The Voice Handicap Index, Rösthandikappindex (RHI), was distributed to a group of voice patients (n = 88) and a group of non-voice patients (n = 110). The reliability of the domains and the combined items of RRL was high according to Cronbach’s alpha with alpha values ranging from 0.82 to 0.90. There was a strong relation between the self–estimated voice quality and the scores on RRL, and the RRL- questionnaire was shown to differentiate between voice patients and non-voice patients. These results indicate that the construct validity of the questionnaire is good. Pearson’s correlation analysis demonstrated a significant negative correlation between the domains and total scores of RRL and RHI. This strong relation between “the gold standard”, RHI, and RRL proved that the criterion validity of the questionnaire is good. In summary the results show that RRL has a high reliability and good validity, in addition to this, the questionnaire is short and requires minimal work. The questionnaire is therefore considered to be a reliable and valuable addition to the clinical assessment of voice disorders.
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Tessier, Annie. "Toward an understanding of weight-related quality of life." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86620.
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Introduction: Obesity is a pandemic that impacts on the ability of people to lead a fulfilling life. Improving the quality of life of obese people (referred to as weight-related quality of life-WRQL) has become a complementary objective to weight loss. The identification of the contributors to WRQL could enable the development of targeted interventions. In addition, WRQL has multiple facets that can be measured. The identification of the content of a measure could ensure that the measure selected consists of domains that are expected to be affected by the intervention. It is important to verify that the definition of a construct has not changed with time and that the content of a measure continues to correspond to people's experience with the condition. The Impact of Weight on Quality Of Life questionnaire (IWQOL-Lite) is widely used. Its content was generated with a sample of 20 participants and has not been revised since its development, 15 years ago.Objective: To improve the effectiveness of interventions for obese people by enhancing the understanding and measurement of the impact of obesity on quality of life.
Methods: Frameworks were hypothesized based on the Wilson Cleary conceptual model and tested on 2 different samples with multiple linear regression, path analysis, and structural equation modeling. The content of the IWQOL-Lite was analyzed, first by comparing it to the description of people's experience with obesity obtained through an online focus group. Secondly, the content of the questionnaire was mapped to the International Classification of Functioning, Disability, and Health (ICF) by 21 health professionals.
Results: The frameworks identified obesity, cardiopulmonary functions, mental symptoms, functional status in regard to activities of daily living and mobility as variables affecting WRQL. There appears to be differences across genders. The findings suggested that the IWQOL-Lite has good content validity but may benefit from some revisions.
Conclusion: Weight, symptoms associated with obesity, and functional limitations are part of the contributors of WRQL and may need to be targeted to lead to improvement. Interventions may need to be gender specific. The findings support the continued used of the IWQOL- Lite.
Introduction: L'obésité est une pandémie mondiale qui affecte l'habileté des gens à poursuivre une vie satisfaisante. L'amélioration de la qualité de vie des gens obèses (qualité de vie en lien avec le poids - QdV-P) est devenue un objectif complémentaire à la perte de poids.
L'identification des déterminants de la QdV-P nous permettrait de développer des interventions ciblées. GdV-P a plusieurs facettes mesurables. L'identification du contenu d'une mesure peut assurer que la mesure sélectionnée consiste en des domaines qui devraient être affecté par l'intervention. De plus, il est important de vérifier que la définition du concept n'a pas changé avec le temps et que le contenu continue à correspondre au vécu des personnes obèses. Le questionnaire sur la qualité de vie liée à la santé (IWQOL-Lite) est utilisé fréquemment. Le contenu a été généré par un échantillon de 21 participants, et n'a pas été révisé depuis son développement, il y a 15 ans.
Objectif: Améliorer l'efficacité des interventions pour les personnes obèses par l'accroissement de la compréhension et de la mesure de l'impact de l'obésité sur la qualité de vie.
Méthodes: Les structures sous-jacentes au concept de la qualité de vie chez les personnes obèses ont été présumées à partir du modèle conceptuel de Wilson et Cleary et testées dans 2 échantillons différents de personnes avec une régression linéaire multiple, analyse des pistes causales, et modélisation d'équation structurale. Le contenu du questionnaire IWQOL-Lite a été analysé, premièrement, en comparant la description du vécu de personnes ayant un excès de poids, obtenue lors d'un groupe de discussion sur Internet. Deuxièmement, le contenu du questionnaire a été jumelé a la Classification Internationale du fonctionnement, du handicap et de la santé (CIF) par 21 professionnels de la santé.
Résultats: Les structures développées identifient l'obésité, les fonctions cardio-pulmonaires, symptômes mentaux, statut fonctionnel en ce qui a trait aux activités de la vie quotidienne et la mobilité comme étant des variables affectant la qualité de vie chez les personnes obèses. Il semble y avoir des différences selon les sexes. Les résultats suggèrent que le contenu de l'IWQOL-Lite est valide mais pourrait bénéficier de quelques révisions.
Conclusion: Le poids, les symptômes associés à l'obésité et les limites fonctionnelles font partie des déterminants de la qualité de vie des personnes obèses et doivent possiblement être ciblés pour son amélioration. Les interventions ont peut être besoin d'être spécifiques selon le sexe de la personne. Les résultats supportent l'utilisation du IWQOL-Lite.
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Hocaoglu, Mevhibe Banu. "Measuring health-related quality of life in Huntingtons' disease." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553073.
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Huntington's Disease (HD) is a fatal, neurodegenerative disease for which there is no known cure. The thesis describes the impact of Huntington's disease on health-related quality of life and reports the development and validation of the first disease specific questionnaire HDQ-D2 with established psychometric measurement properties which address the aspects of quality of life considered important to persons living with Huntington's disease. Literature review revealed that studies have relied on various generic health and quality of life instruments to measure patient experiences of living with HD. Generic instruments may not capture the reality of living with HD, address its specific aspects and measure its effect on the quality of life of persons sufficiently. A disease specific health-related quality of life (HRQOL) instrument may facilitate research into HRQOL in HD. The 40-item HDQ-D2 was developed on the basis of experiences of persons living with HD and consequently covers areas of concern which are of particular importance to this group. The development and validation process comprised three stages. In-depth interviews with 31 persons living with HD generated items for the item selection questionnaire (HDQ-D1). The 81-HDQ-D1 was administered to 313 persons living with HD in twelve different countries to select 40 items for HDQ-D2. Following pre-testing and pilot testing, the 40- item HDQ-D2 was administered to 261 persons living with HD for psychometric evaluation and assessment of measurement properties. Qualitative data was analysed systematically and sequentially. Statistical analysis of the HDQ-D1 and HDQ-D2 data utilized methods of Classical Test Theory and Item Response Theory in triangulation. The 40-item HDQ-D2 covers six key aspects of HRQOL of persons living with HD: cognitive, hopes and worries, services, physical and functional, mood state, self and vitality. It is an acceptable, reliable and valid instrument to measure the extent of impact of HD on the quality of life of persons living with the condition. HDQ-D2 as an instrument can be used for evaluation as well as for research and practice innovation. HDQ-D2 has three primary, six specific and an summary index scales. Thirty-eight of its items can be used to calculate six specific profile scores; thirty-five of its items can be used to calculate three primary profile scores; and twenty-one of its items can be used to calculate a summary index score. The primary and specific profile scores are useful for measuring the impact of interventions upon particular areas of HRQOL and the summary index score is relevant for evaluation of the overall effect of interventions on HRQOL. The development of HOQ-02 provides the option of using psychometrically based patient-generated questionnaires to measure quality of life of persons living with HO. The study contributed to the body of knowledge by designing the first disease specific instrument for measuring health-related quality of life in persons living with HO. For this reason, this newly developed disease specific HRQOL instrument for persons living with HO is a unique contribution to patient reported outcomes research and tools.
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Johansson, Gunvi. "Oral health-related quality of life and young adults /." Malmö : Dept. of Oral Public Health, Malmö University, 2009. http://hdl.handle.net/2043/8591.
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Ahuja, Vinti. "Oral health related quality of life among Iowa adolescents." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/4943.
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Our study involved secondary analyses of the oral health-related quality of life data collected in the Iowa Fluoride Study at the 17-year time-point. Both adolescents and their parents filled out questionnaires related to the assessment of the OHRQoL of the adolescents. In addition, adolescents also underwent clinical examination to assess dental caries, dental fluorosis, orthodontic characteristics, and non-fluoride opacities. Dental casts were also made with the assent of the participants. These casts were later used to estimate the social acceptability of the participants' dental appearance and assess their malocclusion severity, using the Dental Aesthetic Index (Cons et al, 1978). This study assessed the relationships between the OHRQoL of Iowa adolescents and the presence of selected oral conditions, such as dental caries, dental fluorosis, and malocclusion.
Based on the multivariable analyses, dental caries and malocclusion severity (reflected by DAI score) were the two oral conditions that were found to be significantly associated with poorer OHRQoL in adolescents. In addition, the influence of sex on adolescents' perceptions of OHRQoL was found to be statistically significant in our study and being female was associated with poorer OHRQoL.
The findings of our study corroborate the results of other investigations that have demonstrated significant associations between: i) dental caries and OHRQoL (Arrow P, 2013; Barbosa et al, 2013; Bastos et al, 2012; Castro et al,2010; Do and Spencer, 2007; Martinis et al, 2012); ii) malocclusion and OHRQoL (Foster Page et al., 2005; Do and Spencer, 2007; Locker et al, 2007; Bernabe et al, 2008; Agou et al, 2008; O'Brien et al, 2006; Feu et al, 2010; Ukra et al, 2013); and iii) sex and OHRQoL (Foster Page et al, 2005; Calis et al, 2009; Bos et al, 2010; Barbosa et al, 2013; Ukra et al, 2013).
Thus, oral conditions such as dental caries and malocclusion can be a source of stress and can have a negative impact on the life of an individual and can impede their ability to succeed. Females tend to be more sensitive to the negative impact of oral health conditions. Thus, in order to better understand the impact of oral health conditions, subjective measures should be used in conjunction with normative measures or clinical measures of assessing oral health. This can help in better treatment planning, and better allocation of resources, as oral health perceptions can vary for different individuals.
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Brooks, Robert School of Community Medicine UNSW. "Health related quality of life of intensive care patients: Development of the Sydney quality of life questionnaire." Awarded by:University of New South Wales. School of Community Medicine, 1998. http://handle.unsw.edu.au/1959.4/17465.
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This thesis has three main research aims. First the development of a questionnaire to measure HRQOL of ICU patients. Second, to examine a model of HRQOL proposed to assist with the development of the questionnaire. Third, to examine the HRQOL outcomes of patient after hospital discharge. The proposed model is based on a review of conceptual issues related to Quality of Life (QOL), Health Status and HRQOL. After a content analysis of a broad range of definitions of QOL, Health Status and HRQOL, QOL was defined as a dynamic attitude, continually being modified by experience. It is a function of the cognitive and affective appraisals of the discrepancies between domain specific perceptions and expectations. HRQOL was defined as an individuals cognitive and affective response to, or the QOL associated with, their health status. Health status was seen to consist of two health dimensions, physical and psychological health, with each dimension being composed of a number of component measures assessed subjectively. The developed questionnaire, the Sydney Quality of Life (SQOL) had good construct validity, based on substantial correspondence between qualitative and quantitative data, and internal consistency data (factor analysis and Cronbach's alpha). It had good concurrent validity in relation to the Sickness Impact Profile. The second order factor analysis of the SQOL suggested that health status may consist of three dimensions, physical health, positive mental health and negative mental health. The HRQOL model when formally examined, using Structural Equation Modelling (using LISREL), was not supported. However, exploratory modelling supported the separation of mental health into positive and negative components. The structure of HRQOL was different for patients than for the community from which they came. Patients QOL was determined largely by positive mental and physical health, whereas community members QOL was largely determined by negative mental health. Sixty three percent of patients at 12 months after discharge had significantly worse physical and functional health, lower satisfaction with their lives, lower positive affect and poorer QOL. Overall, mental health adapts rapidly to the impact of serious physical ill health and hospitalisation. Implications for clinical practice are examined.
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Kurt, Esra. "Associations between lipid composition, shelf life and sensory quality in ruminant meats." Thesis, University of Bristol, 1999. http://hdl.handle.net/1983/a77d9a0c-f888-4650-b6b8-7c1b8f5cee45.
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Wong, C. Y. Macrina. "Health-related quality of life in patients with cardiac arrhythmias." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36887171.
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Collin, Bagewitz Ingrid. "Prosthodontics, care utilization and oral health-related quality of life /." Malmö : Malmö högskola, 2007. http://dspace.mah.se/handle/2043/3896.
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McNutt, Matthew David White Raymond P. "The impact of pericoronitis on health related quality of life." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,953.
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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2007.Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Master of Science in the School of Dentistry (Orthodontics)." Discipline: Orthodontics; Department/School: Dentistry.
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Adams, Robert John Trenaman. "Health-related quality of life and psychological aspects of asthma /." Title page, contents and introduction only, 1998. http://web4.library.adelaide.edu.au/theses/09MD/09mdt792.pdf.
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Ahmed, Sara 1974. "Response shift and health-related quality of life post-stroke." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84979.
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There is growing consensus that health-related quality of life (HRQL) outcomes are important for the allocation of scarce medical resources and for facilitating clinical decision-making. However, because most instruments of HRQL are self-report measures inappropriate conclusions may be drawn from studies that assess changes in HRQL over time or between groups. If the individuals evaluating themselves experience a response shift (defined as changes in their internalized standard of evaluating their level of functioning, in their values, or in their conceptualization of the target construct), then measures taken over time or between groups are no longer comparable. To date, response shift has not been formally assessed in the stroke population, and only to a limited extent in the HRQL field. The global objective of this thesis was to examine how the experience of recovering from a stroke modifies people's perception of their health-related quality of life (HRQL), and the extent to which response shift occurs during the first six months post-stroke.The first study used structural equation modeling for data from a prospective cohort to evaluate response shift by examining changes in a theoretical model of HRQL based on the measurement model of the Medical Outcome Study 36-Item Short Form Health Survey (SF-36). This study found no evidence of reconceptualization and changes in internal standards over time, but suggested that if response shift does occur with stroke it is likely to be mediated by the event itself and not the recovery process. Two subsequent studies evaluated response shift using the then test (a retrospective assessment of HRQL) and an individualized measure of HRQL. The data collection for these studies was incorporated into a randomized controlled trial. The results from the then test provided support for the occurrence of response shift among persons with stroke with no such effect in a control group. Changes on the individualized measure of HRQL showed that individuals with stroke experienced a reconceptualization and a change in values between 6 and 24-weeks post-stroke. A final comparison of the three techniques evaluated in this thesis provided the basis for proposed guidelines for future assessments of change in HRQL based on the comparative feasibility and validity of the methods. To date, there is evidence to show that individuals undergoing changes in physical health experience changes in internal standards of health and values. If response shift is not measured and accounted for, inappropriate conclusions regarding the impact of a disease such as stroke or the efficacy of a treatment intervention may go unnoticed.
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Jung, Helen. "Physical performance and health-related quality of life post-stroke." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33788.
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Reduced levels of health-related quality of life (HRQL) post-stroke are an important issue to address in rehabilitation. Despite improvement in function over time, HRQL remains poor for many stroke survivors. This longitudinal study is aimed at estimating the extent to which physical performance, social, and psychological functioning influence HRQL.Forty-three community-living persons with stroke were recruited to participate in a six-week intervention preceded and followed by a performance- and interview-based evaluation assessing different levels of disability and functioning. HRQL was measured by the VAS of the EQ-5D.
Regression models generated cross-sectionally demonstrated that physical performance, social, and psychological functioning explained up to 90% of the variation in HRQL. A GEE model revealed that, over time, only upper extremity functioning had a significant relationship with HRQL.
Much attention has already been focused on increasing physical performance in rehabilitation. However, clinicians should consider other components that affect HRQL directly or indirectly through physical performance. Only by treating the different components of functioning at various levels can HRQL be ultimately increased.
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Hilari, Katerina. "Assessing health-related quality of life in people with aphasia." Thesis, City University London, 2002. http://openaccess.city.ac.uk/7471/.
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Background: Health related quality of life (HRQL) measures are becoming increasingly used in the evaluation of health care interventions. They allow us to better understand the impact of disease on a patient's life as a whole and to incorporate the patient's perspective in clinical decision making and in the evaluation of health care. A number of studies have explored the HRQL of people with stroke. Still, due to a number of conceptual and methodological issues, there is no clear understanding of the HRQL of a stroke subgroup: people with aphasia. Aims: The broad aim of this research was to explore the HRQL of people with chronic aphasia following stroke in a way that could be replicated in clinical practice. Thus, a single stroke-specific scale (the SS-QOL) was chosen for the assessment of HRQL. The specific research questions that were addressed were: A) Can an acceptable, reliable and valid version of the SS-QOL be developed for people with chronic aphasia? This involved: i) development of an aphasia-adapted version of the SS-QOL and ii) evaluation of its psychometric properties. B) What are the predictors of HRQL in people with chronic aphasia, as measured by the aphasia adapted version of the SS-QOL? Methods: The development of an aphasia-adapted version of the SS-QOL involved consultation with professionals with experience in measure development, language and aphasia, and pilot testing for the modification of the instrument, and a pre-test of the adapted version with 18 people with aphasia. This process resulted in the Stroke and Aphasia Quality of Life Scale (SAQOL). A cross-sectional interview-based survey study was undertaken to evaluate the psychometric properties (acceptability, reliability and validity) of the SAQOL and to determine the predictors of HRQL as measured by the SAQOL. Convenience sampling was used in the pilot and pre-test studies and cluster sampling in the survey study. Measures: HRQL was measured with the SAQOL. In the construct validation of the SAQOL, the following measures were used: for emotional distress the GHQ-12, for cognition the RCPM, for activities the FAI, for social support the SSS and for language the FAST and the ASHA-FACS. Potential predictors of HRQL included demographic, stroke-related variables and variables implicated in previous research or of theoretical interest measured with the following instruments: the GHQ-12, the FAI, the SSS, the ASHA-FACS, the RCPh1 and the PSI (patients' satisfaction with stroke care). Results A) i) Development of an aphasia-adaptedv ersion of the SS-QOL resulted in the SAQOL, an interview administered self-report measure. People with moderate or mild receptive aphasia (as determined by a score of >_ 7 in the receptive domains of the FAST) found the SAQOL acceptable and were able to self-report to it. A) ii) Psychometric evaluation: 83 out of 95 participants self-reported on the SAQOL. The results supported the reliability and the validity of the overall SAQOL, but not of its subdomains' structure. A shorter 39-item version was derived through factor analysis (SAQOL-39). This instrument had a stable, conceptually clear 4-factor structure (physical, psychosocial, communication and energy) and high acceptability, internal consistency [scale(a= .93) and subdomains' (a=. 74-. 94)], test-retest reliability [scale (ICC=. 98) and subdomains' (ICC=. 89-. 98)] and construct validity [corrected domain-total correlations (r=. 38-. 58), subdomains' convergent (r=. 55-. 67) and discriminant (r=. 02-. 27), and scale's discriminant (r=. 19-. 31) and correlated measures (r=. 45-. 58)]. B) Predictors of HRQL: High emotional distress, reduced involvement in home and outdoors activities, high communication disability and >_2 comorbid conditions predicted poorer HRQL (adjusted R2=. 52). Stroke type (infarct vs haemorrhage) and demographic variables (age, gender, ethnicity, marital status, employment status and socioeconomic status) were not significant predictors of HRQL in these participants. Conclusions:The SAQOL-39 is an acceptable, reliable and valid measure for the assessment of HRQL in people with chronic aphasia. Further testing is needed to establish the usability of this measure in evaluative research and routine clinical practice. Poor HRQL is predicted by distress, reduced involvement in activities, communication disability and comorbidity. Service providers need to take these factors into account when designing intervention programmes.
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Hazell, Michelle Louise. "Health related quality of life in adults with respiratory symptoms." Thesis, Manchester Metropolitan University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429472.
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McClimans, Leah Marian. "Measurement and meaning in health-related quality of life research." Thesis, London School of Economics and Political Science (University of London), 2007. http://etheses.lse.ac.uk/2954/.
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In this thesis I take up the topic of our understanding of questions in a detailed case study of non-utility measures of health-related quality of life. I argue that efforts to standardize these measures lead to limitations in our ability to understand and measure quality of life. In the first half of this thesis I describe two types of bias that affect quality of life measures despite efforts to validate them. On the one hand, quality of life measures can perpetuate ethnocentric understandings of quality of life. On the other hand, respondents often understand the questions in these measures very differently than researchers imagined. I argue that the residual bias found in quality of life measures is the result of two assumptions built into the use of construct validity: 1) when a measure's outcomes confirm our hypotheses, we are warranted in having greater confidence in the accuracy of our theory 2) respondents understand the questions and answers in our measures in the same way as researchers imagined they would. In the second half of this thesis I argue that the limitations of construct validity stem from the logic of asking questions, a logic which precludes standardization. I propose that quality of life measures ought to be understood differently-they are not independent instruments capable of unambiguous claims, but rather one element in a dialogic framework whose questions and outcomes serve as the starting point for further inquiry. Finally, I examine what might have motivated the misguided use of construct validity. I suggest that the motivation lies in an erroneous picture of the human subject. I argue for an alternative picture that allows me to introduce an ethical dimension to our questions about quality of life.
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Mat, Amdah. "The determinants of children's oral health related quality of life." Thesis, University of Sheffield, 2010. http://etheses.whiterose.ac.uk/14535/.
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Oral health-related quality of life (OHRQOL) refers to the impact of oral disorders on aspects of everyday life that are important to patients and persons, with those impacts being of sufficient magnitude, whether in terms of severity, frequency or duration, to affect an individual's perception of their life overall. OHRQOL has become an important focus for assessing the impact of oral conditions on every day life, sometimes as an outcome of clinical care (e.g. Allen et al 2001; Locker 2004; Marshman and Robinson 2007). To date, several studies have explored children's OHRQOL using such child-centred measures. These studies show that oral health can impact on children's functioning and well-being. However, none of these studies have incorporated a broad range of clinical and other non-clinical variables factors that may influence children's OHRQOL or attempted to explicitly test the relationships between them within a theoretical model. Such research hopefully would highlight important issues to further our understanding of the antecedents and consequents of children OHRQOL in order to facilitate effective intervention strategies. Thus, this research alms to assess relationships between clinical and non-clinical variables in relation to children's OHRQOL. The theoretical model chosen to guide the research is that by Wilson and Cleary (1995), which classifies the variables at five main levels; clinical status, symptom status, functioning, general health perceptions and overall quality of life. The model has been used in adults in relation to several health chronic conditions, including oral health (Baker et al 2007; Baker et al 2008) but is relatively untested in children's oral health and oral health related quality of life. 12 This thesis is structured as follows: Chapter One captures the overview of the research. Chapter Two is a narrative reVIew of the literature. It considers health as conceptualized within different approaches; the biomedical, psychosocial model and bio-psychosocial models, to develop an understanding on OHRQOL. The review also introduces two models feasible for use in the study; Locker (1988) and Wilson and Cleary (1995). The Wilson and Cleary model is then used to structure a brief discussion on individual factors, sense of coherence, self esteem, oral health beliefs and health locus of control that may play a role in OHRQOL. Included also are environmental factors such as parental income, education level and work status. Chapter Three summarises the rationale, aim and objectives of the study. It argues that clinical and non clinical variables impact on children's QOL. Individual factors and environment issues may be important factors that need to be considered in understanding children's oral health. Furthermore, no study so far has systematically considered these factors guided by a theoretical framework. The study therefore aimed to identify the determinants and consequences of oral health related quality of life in children. The objectives are as follows; • To test the relationships between clinical variables, symptom status, functioning, general health perceptions and overall well-being as hypothesised within Wilson and Cleary's model of patient outcomes. • To examine whether socio-demographic and individual difference factors influence children's OHRQOL and the key relationships identified within the Wilson and Cleary model. • To explore different configurations of SOC, COHRQOL and the model Chapter Four describes the translation procedures conducted to achieve high quality translated measures that are suitable for children. Chapter Five details the material and methods including a brief description on the data analysis strategy, missing data management and data analysis management. 13 Chapter Six presents the research findings. The sample had good clinical status. Broadly speaking in lagged analyses the linear relationships of the model were not strongly supported, whereas individual factors, notably sense of coherence, were consistently linked to symptoms, functional limitation and overall quality of life. Chapter Seven brings together the discussion highlighted from the findings. Chapter Eight highlights the major conclusions and summarises the recommendations arising from the research. Chapter Nine lists the references. Appendices section contains copies of key research documents.
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Dritsakis, Giorgos. "The 'music-related quality of life' of cochlear implant users." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/413587/.
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Outcome measures for adult cochlear implant (CI) users are needed to evaluate music rehabilitation tools. Music questionnaires developed for CI users may capture real-world music experiences better than music perception tests but have not been designed to measure outcomes. A new reliable and valid instrument measuring a wide range of music experiences and the impact of music on the quality of life (QOL) of adult CI users could be more appropriate for the assessment of music rehabilitation. This PhD thesis made steps towards the development of such a measure. Music-related Quality of Life (MRQOL) was defined as a function of music experiences and their importance in life. On the basis of this concept, two initial pools of questionnaire items were developed, one assessing musical abilities, attitudes and activities and another one assessing their importance. The items were generated using focus group data from 30 adult CI users and reviewed by 24 professionals for face validity and refinement. After completion of both sets of questions by 147 adult CI users, 18 items were selected for each set with the use of traditional psychometric techniques. The items grouped together into two meaningful domains (perception and engagement) with high reliability and some evidence for construct validity. Scores of ‘music perception and engagement’ and importance for the 18 items can be combined to measure the impact of music on QOL. The meaning of individual ‘impact’ scores and the ability of the questionnaire to measure changes have to be further studied. This thesis broadens the understanding of CI users’ relationship with music and the effects of music on their QOL. Novel aspects of music experience were identified. The MRQOL measure has the potential to become a standard measure of music-specific outcomes and of the impact of music on the QOL of adult CI users and hearing-impaired adults in general, with potential clinical utility.
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Agala, D. A., and S. E. Devis. "Health-related quality of life children with acute hematogenous osteomylitis." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32549.
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Acute hematogenous osteomyelitis (AHO) is the most common type of osteomyelitis, an infection of bone that occurs in children.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32549
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Hart, Catherine K. "Health-related Quality of Life in Children with Aerodigestive Disorders." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin151091845523319.
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Javdan, Nazafarin. "Silver Diamine Fluoride and Oral Health-Related Quality of Life." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4698.
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Purpose: The purpose of this study was to study the association between Silver Diamine Fluoride (SDF) and Oral Health-Related Quality of Life as assessed by “The Early Childhood Oral Health Impact Scale” questionnaire. Methods: Parents of healthy children (ASA I and II) ages 1-5 with early childhood caries with reversible pulpitis who had application of SDF filled out a questionnaire at baseline and again after one month. The questionnaire was designed to evaluate the child’s behavior, physical abilities, pain, temperament, and how well the child gets along with others. Results: Wilcoxon Signed Rank Test was used to determine if responses to various ECOHIS items and the total scores were different between the two time points. Conclusion: Children with dental caries who had application of SDF reported less dental pain, less eating problems, higher quality of sleep and overall higher quality of life at one-month follow up compared with the baseline.
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Johansson, Veronica. "Oral health-related quality of life and patient payment systems /." Malmö : Dept. of Oral Public Health, Malmö University, 2009. http://dspace.mah.se/bitstream/2043/9017/1/Veronica%20Johansson%20Avhandling.pdf.
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Bagewitz, Ingrid Collin. "Prosthodontics, care utilization and oral health-related quality of life." Malmö [Sweden] : Malmö högskola, Dept. of Prosthetic Dentistry, Dept. of Oral Public Health, Faculty of Odontology, 2007. http://catalog.hathitrust.org/api/volumes/oclc/122895139.html.
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Leung, Julie. "Health-related quality of life in women with gynaecological cancer." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/130759/1/Julie_Leung_Thesis.pdf.
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A diagnosis of gynaecological cancer and its treatments have considerable impact on affected women's quality of life. The purpose of this study was to establish patient and clinical characteristics associated with better quality of life after the treatment of cancer, guided by the revised Wilson and Clearly model. The findings in this study will have substantial implications for clinical practice and will inform psychosocial interventions aimed at improving the quality of life of patients in the future.
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Seward, Rebecca. "The relationship between discounting immediate and former life statuses related to quality of life." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/theses/2691.
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The purpose of the current study is to evaluate the relationship between discounting immediate and former life statuses prior to death related to quality of life across the lifespan. A discounting survey was completed by 83 participants in which they were asked to make hypothetical choices regarding returning back to an age they preferred or remaining at their current age prior to dying. In addition, participants completed surveys measuring quality of life, death depression, and death anxiety. Results indicated that participants who reported low quality of life and experienced high depression and anxiety towards death responded more impulsively to the discounting survey, engaging in steeper discounting. Additionally, results indicated that a positive correlation between participants aged 30 to 50 years old and AUC exists, indicating that as age increases, impulsivity decreases. However, this same trend was not evident in participants over the age of 65, yielding no correlation. Strengths and limitations, implications of the current study’s findings, and opportunities for future research are discussed.
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Alrajhi, Waleed. "Quality of life and health related quality of life in patients with end stage renal disease : an Omani context." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/3bb00c25-8293-4bbc-9a54-195fe95677ae.
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Background: ESRD is a serious and irreversible condition. Understanding the impact of ESRD and its treatment on an individual's QoL is important. There are limited studies found that assess QoL and Health-related QoL in Arab Muslim patients, and Oman in particular. Method: A cross-sectional, correlational study was conducted in four phases. Phase One explored the conceptual basis of QoL and how that has been assessed in ESRD patients. Phase Two explored the understanding and acceptability of the concepts within Omani patients using cognitive interviewing and individualised QoL instrument. Phase Three tested the feasibility of the main study design. Phase Four assessed the level and predictors of QoL/HRQoL from 13 haemodialysis units across Oman; and tested psychometric adequacy of key measures using exploratory and confirmatory factor analysis. Findings: Phase 1: showed inconsistencies and inappropriate us of the terms QoL and HRQoL in literature. A range of measures used to examine QoL/HRQoL. Phase 2: revealed some cultural sensitivities in two items of the SF36v2 and QoLI-D measures but generally were accepted. The SEIQoL-DW instrument supported the finding that QoL is a meaningful concept but one significant difference was the importance and universality of religion/spirituality as a key aspect of QoL. Phase 3: showed that chosen study approach was feasible and acceptable. Six nurses were identified and trained to support in patient recruitment and data collection. Phase 4: participants were 445 with mean age 46.59. Majority were male (56.3 %), married (62.5%), and employed (37.5%). Significant impairment in HRQoL was found for most of SF36v2 scales: PF 52.24, RP 54.24, BP 56.72, GH 53.18, VT 52.90, SF 60.50, RE 56.25, MH 63.75, respectively. Anxiety and depression symptoms were the most significant predictors and fatigue and pruritus were next. Also Muslims patients with ESRD encounter difficulties in performing their religion obligations due to the disease. Psychometric testing revealed that SF-36 is a three-factor structure with the inclusion of a separate role functioning component; and HADS one and two factor solutions were supported. Conclusion: future studies should continue to identify factors that influence quality of life and determine interventions that enhance a person’s sense of well-being.
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Ramsay, Pam. "Quality of life following prolonged critical illness : a mixed methods study." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/8310.
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Survival following critical illness is associated with a significant burden of physical and psychosocial morbidity and recovery is often protracted and/or incomplete. Recovery has been measured using, almost exclusively, generic health-related quality of life (HRQoL) questionnaires. There is, however, an inexorable lack of consensus on the conceptual definition of HRQoL, and existing measures have tended to reflect overtly biomedical concerns such as morbidity and impairment at population level. Limited empirical or theoretical work has examined the extent to which widely used measures reflect the individual’s concerns, “health”-related and otherwise. The primary aims of this PhD are to examine HRQoL among a rarely studied sub group of the critically ill patient population: survivors of prolonged critical illness, and to explore the extent to which professionally endorsed measures capture their experiences of and perspectives on the recovery process. The implications of “patient-centredness” are both diverse and far-reaching in terms of policy, practice and critical care outcomes research, and are discussed throughout. A review of the literature among a well studied sub group of the patient population (survivors of Adult Respiratory Distress Syndrome) identified the widespread use of generic and ancillary measures which were invariably developed for use among other patient populations. This approach was seen to offer limited insight to the putative relationship between critical illness-related morbidity and HRQoL. Reflecting existing professional recommendations and practice, the Short Form 36 (SF-36) and the EuroQoL were administered by post to 20 survivors of prolonged critical illness at up to 6 months following ICU discharge. Each subsequently participated in a semi-structured interview, the purpose of which was to explore experiences and perceptions of ongoing morbidity within the contexts of the critical illness “journey” and, importantly, everyday life. A small number (n=5) participated in cognitive interview in order to explore both the everyday logistics of questionnaire completion and the often startling inconsistencies between verbal and questionnaire response. Analysis here revealed the unexpectedly diverse and normally hidden processes through which survivors interpreted and responded to standardised questionnaire items, challenging traditional (i.e. psychometric) notions of validity. Data from the semi-structured interviews were “mapped” onto the dimensions of the SF-36, revealing the highly contextualised and complex inter-relatedness of biomedically defined and ostensibly discrete aspects of experience. Morbidity was conceptualised by survivors in terms of the adaptive and interpretive processes adopted in everyday life (as opposed to a source of loss) and was generally under-reported in questionnaire form. An alternative explanatory framework for HRQoL was subsequently developed. Data were also analysed with reference to the “biographical narrative” of critical illness, a strategy which revealed the significance of survivors’ own stock of “life experience” (health-related and otherwise) in these interpretive and adaptive processes. The unexpectedly phlegmatic nature of survivors’ accounts directed attention to the narrative form, lending credibility to survivors’ claims that “things weren’t that bad”; accounts of seemingly intolerable morbidity were perceived, for example, as “a lucky escape”. This data also revealed, however, the influence of shortfalls in the processes and delivery of acute hospital rehabilitation upon the efficacy of these interpretive and adaptive processes. Mixed methods approaches to HRQoL, in summary, offer significant insights into survivors’ conceptualisations of morbidity, recovery, quality of life and the complex inter-relationships therein. Attention to the processes of adaptation also offers significant potential for the development of patient-centred measures of outcome and the expedition of the recovery process in ways which are most meaningful to survivors.
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Hofhuis, Jozefina Gerarda Maria. "Health related quality of life in critically ill patients a study of health related quality of life in critically ill patients admitted on the intensive care /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13442.
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Soe, Ko Ko. "Dental caries, related treatment need and oral health related quality of life in Myanmar adolescents." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326061.
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Bishop, Michael W. M. D. "Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544150.
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Warren, Ginger Parrish. "Respiratory-related quality of life among people exposed to Libby asbestos." Thesis, Montana State University, 2011. http://etd.lib.montana.edu/etd/2011/warren/WarrenG0511.pdf.
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The purpose of this descriptive study was to explore respiratory-related quality of life among people that have been exposed to Libby amphibole asbestos. This thesis analyzed data from a descriptive research study conducted by a team from Montana State University College of Nursing in collaboration with the Center for Asbestos-Related Diseases (CARD) clinic in Libby from September 1, 2006 through August 31, 2007. The main goal of the parent study was to examine the bio-psychosocial health status of persons exposed to Libby amphibole asbestos. This thesis augments that work by examining respiratory-related quality of life from a Libby sample and comparing with other groups reported in the scientific literature. Findings show that overall respiratory-related quality of life for persons exposed to Libby asbestos was similar to other respiratory-related disease cohorts. Implications to nursing practice and limitations of the study are discussed.
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Hallberg, Inger. "Health-Related Quality of Life in Postmenopausal Women with Osteoporotic Fractures." Doctoral thesis, Linköpings universitet, Omvårdnad, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51524.
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Background: The global burden of osteoporosis includes considerable numbers of fractures, morbidity, mortality and expenses, due mainly to vertebral, hip and forearm fractures. Underdiagnosis and undertreatment are common. Several studies have shown decreased health-related quality of life (HRQOL) after osteoporotic fracture, but there is a lack of data from long-term follow-up studies, particularly regarding vertebral fractures, which are often overlooked despite patients reporting symptoms. Aim: The overall aim of this thesis was to evaluate the usefulness of a recent low-energy fracture as index event in a case-finding strategy for osteoporosis and to describe and analyse long-term HRQOL in postmenopausal women with osteoporotic fracture. The specific aims were to describe bone mineral density and risk factors in women 55-75 years of age with a recent low-energy fracture (I), estimate the impact of osteoporotic fractures on HRQOL in women three months and two years after a forearm, proximal humerus, vertebral or hip fracture (II), investigate the changes and long-term impact of vertebral or hip fracture on HRQOL in women prospectively between two and seven years after the inclusion fracture (III), and describe how HRQOL and daily life had been affected in women with vertebral fracture several years after diagnosis (IV). Design and methods: Data were collected from southern Sweden between 1998 and 2008. A total of 303 women were included in Study I, and this group served as the basis for Studies II (n=303), III (n=67), and IV (n=10). A cross-sectional observational, case-control design (I), and a prospective longitudinal observational design (II-III) were used. In Study IV a qualitative inductive approach with interviews was used and data were analysed using a qualitative conventional content analysis. Results: The type of recent fracture and number of previous fractures are important information for finding the most osteoporotic women in terms of severity (I). Hip and vertebral fractures in particular have a significantly larger impact on HRQOL evaluated using the SF-36 than do humerus and forearm fractures, both during the three months after fracture and two years later, compared between the different fracture groups and the reference population (II). Women who had a vertebral fracture as inclusion fracture had remaining pronounced reduction of HRQOL at seven years. At the mean age of 75.5 years (±4.6 SD), the prevalence of vertebral fracture suggests more negative long-term impact on HRQOL, more severe osteoporosis and a poorer prognosis than a hip fracture does, and this effect may have been underestimated in the past (III). Study IV demonstrates that the women’s HRQOL and daily life have been strongly affected by the long-term impact of the vertebral fracture several years after diagnosis. The women strive to maintain their independence by trying to manage different types of symptoms and consequences in different ways. Conclusions and implications: Type and number of fractures should be taken into account in the case-finding strategy for osteoporosis in postmenopausal women between 55 and 75 years of age. The long-term reduction of HRQOL in postmenopausal women (age span 55-75 yr) with vertebral fracture emerged clearly, compared to women with other types of osteoporotic fractures and references in this thesis. The results ought to be taken into consideration when developing guidelines for more effective fracture prevention and treatment, including non-pharmacological intervention for women with osteoporotic fractures, with highest priority placed on vertebral fractures and multiple fractures, to increase or maintain HRQOL.
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Eriksson, Lars E. "HIV therapies : from health-related quality of life to DNA levels /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-519-0/.
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Wong, Wing-yee. "Weight status and health-related quality of life in Hong Kong." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38479382.
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Petersen, Solveig. "Recurrent pain and health related quality of life in young schoolchildren." Doctoral thesis, Umeå : Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1592.
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Basri, Etidal. "Development of a pediatric oral health-related quality-of-life questionnaire." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30808.
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Oral and dental health illness among children is prevalent, and associated impairments are common. However, the impact of these conditions on the lives of children has yet to be determined. The objective of this study was to carry out the initial development phase for an oral health-related quality of life instrument to assess the impact of oral and dental conditions on children aged 3--5 years. Items were generated through literature review, the use of a conceptual model, and by interviewing parents and health professionals. The most frequent and important items were retained to comprise the Pediatric Oral Health Questionnaire, evaluating five dimensions: physical, functional, emotional, and social status, and impact on the family. This preliminary questionnaire is the first to be developed for the measurement of oral health-related quality of life (QoL) in children.
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Wong, Wing-yee, and 王詠怡. "Weight status and health-related quality of life in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39724669.
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Pang, Har-ling Harry, and 彭遐寧. "A study of oral health-related quality of life during adolescence." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B42182098.
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Wong, King-ho, and 黃競浩. "Health-related quality of life of Chinese patients with colorectal neoplasms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193041.
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Increasing number of people is diagnosed with colorectal neoplasms (CRN) in the form of polyps or cancers. Colorectal cancer (CRC) is one of the most common causes of cancer deaths among Chinese in Hong Kong. Advances in diagnosis and treatments have increased the survival rate of CRN patients, resulting in a large group of cancer survivors. Preserving and maintaining health-related quality of life (HRQOL) has become an important direction in research and clinical care of patients with CRN. This research aimed to evaluate the HRQOL and its association with socio-demographics and disease-related characteristics among patients with CRN, and illustrate how HRQOL data could be converted to preference for the estimation of quality adjustment of life years in health economic evaluations.
This research comprised of three parts. First was the establishment of the validity and reliability of the traditional Chinese version of Functional Assessment of Cancer Therapy-Colorectal (FACT-C) as a HRQOL measure for Chinese patients by a cross-sectional sample of 536 adult patients with CRN. Psychometric testing and concurrent validation of the FACT-C with European Organization for Research and Treatment of Cancer Core Questionnaire plus Colorectal-specific Module Questionnaire and the Short-Form 12-item Health Survey_Version2 (SF-12V2) were carried out. Second was a longitudinal study on the HRQOL of 554 CRN patients at baseline, six (n=479) and twelve (n=414) months of recruitment. The associations of HRQOL with socio-demographics and disease-related factors, and change of HRQOL over time were explored. Comparisons of HRQOL between CRN patients and the general population and among different CRN groups were made. Cross-sectional data were used to develop mapping functions to estimate SF-6D preference scores from FACT-C subscale scores. Third was the application of the health preference scores by CRN stages collected at baseline of the longitudinal study, in combination with survival data extracted from the literature in a Markov model on the cost-effectiveness of different CRC screening strategies (colonoscopy, guaiac and immunochemical fecal occult blood tests) in comparison to no screening in terms of quality-adjusted life-years gained.
This research comprised of three parts. First was the establishment of the validity and reliability of the traditional Chinese version of Functional Assessment of Cancer Therapy-Colorectal (FACT-C) as a HRQOL measure for Chinese patients by a cross-sectional sample of 536 adult patients with CRN. Psychometric testing and concurrent validation of the FACT-C with European Organization for Research and Treatment of Cancer Core Questionnaire plus Colorectal-specific Module Questionnaire and the Short-Form 12-item Health Survey_Version2 (SF-12V2) were carried out. Second was a longitudinal study on the HRQOL of 554 CRN patients at baseline, six (n=479) and twelve (n=414) months of recruitment. The associations of HRQOL with socio-demographics and disease-related factors, and change of HRQOL over time were explored. Comparisons of HRQOL between CRN patients and the general population and among different CRN groups were made. Cross-sectional data were used to develop mapping functions to estimate SF-6D preference scores from FACT-C subscale scores. Third was the application of the health preference scores by CRN stages collected at baseline of the longitudinal study, in combination with survival data extracted from the literature in a Markov model on the cost-effectiveness of different CRC screening strategies (colonoscopy, guaiac and immunochemical fecal occult blood tests) in comparison to no screening in terms of quality-adjusted life-years gained.
Psychometric analysis confirmed that FACT-C had satisfactory reliability, construct validity and responsiveness in Chinese patients Patients with CRN reported worse physical HRQOL but better mental HRQOL and similar health preference score compared to the general population. Disease severity indicated by tumor stage at initial diagnosis was the most significant determinant of HRQOL of CRN patients. Rectal cancer also significantly associated with a decrease in physical HRQOL and health preference scores. Markov modelling showed that immunochemical fecal occult blood (I-FOBT) yearly was the most effective and two-yearly was the most cost-effective screening strategy compared to no screening.published_or_final_version
Family Medicine and Primary Care
Doctoral
Doctor of Philosophy
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Malone, Margaret. "Assessment of health-related quality of life in patients with cancer." Thesis, Cardiff University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357347.
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