Relevant bibliographies by topics / Folic acid in human nutrition

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Folic acid in human nutrition'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 March 2023

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Journal articles on the topic "Folic acid in human nutrition"

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Dunn, Caroline, and Gail Kauwell. "Women's Nutrition: Folate/Folic Acid." EDIS 2015, no. 3 (May 6, 2015): 4. http://dx.doi.org/10.32473/edis-fs265-2015.

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To decrease a baby’s chances of having certain types of births defects, mothers need to have already been consuming enough of the vitamin called folate, or folic acid, before they become pregnant. This article provides information about the folate/folic acid needs of women who are capable of becoming pregnant, including its role in preventing birth defects, sources, and strategies for meeting the recommended intake. This 4-page fact sheet was written by Caroline Dunn and Gail Kauwell, and published by the UF Department of Food Science and Human Nutrition, February 2015. (Photo Credit: Mike Watson Images/moodboard/Thinkstock.com) FSHN15-03/FS265: Women's Nutrition: Folate/Folic Acid (ufl.edu)
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Ratajczak, Alicja Ewa, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, and Iwona Krela-Kaźmierczak. "Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?" Nutrients 13, no. 11 (November 12, 2021): 4036. http://dx.doi.org/10.3390/nu13114036.

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Folic acid, referred to as vitamin B9, is a water-soluble substance, which participates in the synthesis of nucleic acids, amino acids, and proteins. Similarly to B12 and B6, vitamin B9 is involved in the metabolism of homocysteine, which is associated with the MTHFR gene. The human body is not able to synthesize folic acid; thus, it must be supplemented with diet. The most common consequence of folic acid deficiency is anemia; however, some studies have also demonstrated the correlation between low bone mineral density, hyperhomocysteinemia, and folic acid deficiency. Patients with inflammatory bowel disease (IBD) frequently suffer from malabsorption and avoid certain products, such as fresh fruits and vegetables, which constitute the main sources of vitamin B9. Additionally, the use of sulfasalazine by patients may result in folic acid deficiency. Therefore, IBD patients present a higher risk of folic acid deficiency and require particular supervision with regard to anemia and osteoporosis prevention, which are common consequences of IBD.
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Pellis, Linette, Yvonne Dommels, Dini Venema, Ab van Polanen, Esther Lips, Hakan Baykus, Frans Kok, Ellen Kampman, and Jaap Keijer. "High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells." British Journal of Nutrition 99, no. 4 (September 10, 2007): 703–8. http://dx.doi.org/10.1017/s0007114507824147.

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Folate, a water-soluble B vitamin, is a cofactor in one-carbon metabolism and is essential for DNA synthesis, amino acid interconversion, methylation and, consequently, normal cell growth. In animals with existing pre-neoplastic and neoplastic lesions, folic acid supplementation increases the tumour burden. To identify processes that are affected by increased folic acid levels, we compared HT29 human colon cancer cells exposed to a chronic supplemental (100 ng/ml) level of folic acid to cells exposed to a normal (10 ng/ml) level of folic acid, in the presence of vitamin B12and other micronutrients involved in the folate–methionine cycle. In addition to higher intracellular folate levels, HT29 cells at 100 ng folic acid/ml displayed faster growth and higher metabolic activity. cDNA microarray analysis indicated an effect on cell turnover and Fe metabolism. We fully confirmed these effects at the physiological level. At 100 ng/ml, cell assays showed higher proliferation and apoptosis, while gene expression analysis and a lower E-cadherin protein expression indicated decreased differentiation. These results are in agreement with the promoting effect of folic acid supplementation on established colorectal neoplasms. The lower expression of genes related to Fe metabolism at 100 ng folic acid/ml was confirmed by lower intracellular Fe levels in the cells exposed to folic acid at 100 ng/ml. This suggests an effect of folate on Fe metabolism.
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Wright, Anthony J. A., Maria J. King, Caroline A. Wolfe, Hilary J. Powers, and Paul M. Finglas. "Comparison of (6S)-5-methyltetrahydrofolic acidv.folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults." British Journal of Nutrition 103, no. 5 (October 26, 2009): 724–29. http://dx.doi.org/10.1017/s0007114509992339.

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Folic acid (pteroylmonoglutamic acid) has historically been used as the reference folate in human intervention studies assessing the relative bioavailability of dietary folate. Recent studies using labelled folates indicated different plasma response kinetics to folic acid than to natural (food) folates, thus obviously precluding its use in single-dose experiments. Since differences in tissue distribution and site of biotransformation were hypothesised, the question is whether folic acid remains suitable as a reference folate for longer-term intervention studies, where the relative bioavailability of natural (food) folate is assessed based on changes in folate status. Healthy adults aged 18–65 years (n163) completed a 16-week placebo-controlled intervention study in which the relative bioavailability of increased folate intake (453 nmol/d) from folate-rich foods was assessed by comparing changes in plasma and erythrocyte folate concentration with changes induced by an equal reference dose of supplemental (6S)-5-methyltetrahydrofolic acid or folic acid. The relative increase in plasma folate concentration in the food group was 31 % when compared with that induced by folic acid, but 39 % when compared with (6S)-5-methyltetrahydrofolic acid. The relative increase in erythrocyte folate concentration in the food group when compared with that induced by folic acid was 43 %, and 40 % when compared with (6S)-5-methyltetrahydrofolic acid. When recent published observations were additionally taken into account it was concluded that, in principle, folic acid should not be used as the reference folate when attempting to estimate relative natural (food) folate bioavailability in longer-term human intervention studies. Using (6S)-5-methyltetrahydrofolic acid as the reference folate would avoid future results' validity being questioned.
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Nevins, Julie, Maureen Spill, Sharon M. Donovan, Kathryn Dewey, Rachel Novotny, Jamie Stang, Elsie Taveras, et al. "Folic Acid From Supplements or Fortified Foods Consumed During Pregnancy and/or Lactation and Health Outcomes in Mothers and Their Children: A NESR Systematic Review." Current Developments in Nutrition 5, Supplement_2 (June 2021): 795. http://dx.doi.org/10.1093/cdn/nzab046_092.

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Abstract Objectives To inform the Dietary Guidelines for Americans, 2020–2025, USDA and HHS identified the following important public health question for the 2020 Dietary Guidelines Advisory Committee to answer with support from USDA's Nutrition Evidence Systematic Review (NESR) team: What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and lactation and health outcomes? Methods The Committee developed protocols to describe how they would use NESR's systematic review methodology to examine the evidence. NESR conducted a literature search and dual-screened the results using pre-defined inclusion and exclusion criteria for articles published between 1980 and 2019. NESR extracted data and assessed risk of bias of included studies. The Committee synthesized the evidence, developed conclusion statements, and graded the strength of the evidence underlying the conclusion statements. Results This systematic review included 30 articles, most of which were well-designed RCTs. Observational studies had risk of bias concerns. The study populations did not fully represent the diversity of the U.S. population. Conclusions Strong evidence indicates that folic acid supplements consumed before and/or during pregnancy are positively associated with folate status. Moderate evidence indicates that folic acid supplements consumed during lactation are positively associated with folate status. Limited evidence suggests that folic acid supplements consumed during early pregnancy may have a beneficial effect on reducing the risk of hypertensive disorders during pregnancy among women at high-risk versus no supplementation. Moderate evidence indicates that higher versus lower levels of folic acid supplements consumed during pregnancy does not affect the risk of hypertensive disorders during pregnancy among women at low-risk. Moderate evidence indicates that folic acid supplements consumed during lactation does not influence folate levels in human milk. Insufficient or no evidence was available to examine folic acid and gestational diabetes or child developmental, or folic acid from fortified foods and any outcome. Funding Sources USDA, Food and Nutrition Service, Center for Nutrition Policy and Promotion.
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Zadarko-Domaradzka, Maria, Ewa Kruszyńska, and Emilian Zadarko. "Effectiveness of Folic Acid Supplementation Recommendations among Polish Female Students from the Podkarpackie Region." Nutrients 13, no. 3 (March 19, 2021): 1001. http://dx.doi.org/10.3390/nu13031001.

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Adequate folic acid supplementation during the preconception period is an important element in the primary prevention of neural tube defects (NTDs). This study aims to study the effectiveness of folic acid supplementation recommendations among women of childbearing age, and to assess and characterise their awareness about this public health measure. The cross-sectional study included women (N = 1285) aged 22.27 ± 4.6 years old on average. Some of the results were obtained on a subgroup of women (N = 1127) aged 21.0 ± 2.1. This study was performed using a questionnaire. The analysis was performed with the use of a logistic regression model, chi-square test for independence and odds ratio (OR). According to the results, only 13.9% of women supplement folic acid, and 65.3% of them do so daily. A total of 91.1% of the respondents were not aware of its recommended dose and 43% did not know the role it plays in the human body. Among women who do not currently supplement folic acid (N = 1052), 52.4% declared doing so while planning their pregnancy. Women’s awareness about the role of folic acid in NTD prevention (OR = 4.58) and the information they got from physicians (OR = 1.68) are key factors that increased the odds of the women taking folic acid before pregnancy. There is therefore a need for more information and education campaigns to raise awareness about folic acid.
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Cui, Shanshan, Wen Li, Xin Lv, Pengyan Wang, Guowei Huang, and Yuxia Gao. "Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats." Applied Physiology, Nutrition, and Metabolism 42, no. 10 (October 2017): 1015–22. http://dx.doi.org/10.1139/apnm-2017-0158.

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Atherosclerosis is a chronic disease that can seriously endanger human life. Folic acid supplementation modulates several disorders, including atherosclerosis, via its antiapoptotic and antioxidative properties. This study investigated whether folic acid alleviates atherogenesis by restoring homocysteine levels and antioxidative capacity in atherosclerosis Wistar rats. To this end, 28 Wistar rats were randomly divided into 4 groups (7 rats/group) as follows: (i) wild-type group, fed only the AIN-93 semi-purified rodent diet (folic acid: 2.1 mg/kg); (ii) high-fat + folic acid-deficient group (HF+DEF) (folic acid: 0.2 mg/kg); (iii) high-fat + normal folic acid group (folic acid: 2.1 mg/kg); and (iv) high-fat + folic acid-supplemented group (folic acid: 4.2 mg/kg). After 12 weeks, histopathological changes in the atherosclerotic lesions of the aortic arch were determined. In addition, serum folate levels, plasma homocysteine levels, plasma S-adenosyl-homocysteine levels, antioxidant status, oxidant status, and lipid profiles were evaluated. The results show aggravated atherosclerotic lesions in the HF+DEF group. Folic acid supplementation increased concentrations of serum folate. Further, folic acid supplementation increased high-density lipoprotein-cholesterol, decreased plasma homocysteine levels, and improved antioxidant capacity in atherogenic rats. These findings are consistent with the hypothesis that folic acid alleviates atherogenesis by reducing plasma homocysteine levels and improving antioxidant capacity in rats fed a high-fat diet.
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Roth-Maier and Böhmer. "Fortification of Eggs with Folic Acid as a Possible Contribution to Enhance the Folic Acid Status of Populations." International Journal for Vitamin and Nutrition Research 77, no. 4 (July 1, 2007): 297–301. http://dx.doi.org/10.1024/0300-9831.77.4.297.

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The aim of the present study was to evaluate the enrichment of folic acid in eggs by supplementing hens’ diet. Seventy-two hens (LSL) were assigned to 5 dietary groups and supplemented with 0, 0.5, 1.0, 2.0, and 4.0 mg folic acid/ kg feed during an 8-week period. Eggs for folic acid analysis were collected in weeks 4 and 8 and analyzed by microbiological method using L. casei. The performance of the hens was not influenced by the supplementation. The content of folic acid in eggs increased significantly from 3.1 μg/g DM to 5.5 μ g/g DM (week 4) and from 2.1 μ g/g DM to 4.2 μ g/g DM (week 8), respectively. One fortified egg can provide up to 76 μ g folic acid. Additionally the intestinal availability of folic acid in eggs was determined in pigs as an animal model for human nutrition. Six pigs were fitted with ileorectal-anastomosis and received boiled eggs combined with a supplementary diet according to nutrient requirement. The metabolic trial ran for 12 days with a pre-period of 7 days and a collection period of 5 days. Feed and chyme were analyzed for folic acid as mentioned above. The availability of folate in eggs was determined as 68%, which means that one fortified egg provides up to 52 μ g folate equivalent to 13% of the recommended daily intake.
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Krishnaswamy, Kamala, and K. Madhavan Nair. "Importance of folate in human nutrition." British Journal of Nutrition 85, S2 (May 2001): S115—S124. http://dx.doi.org/10.1079/bjn2000303.

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From a public health perspective, some of the new insights into folic acid nutrition are of significance. Folate intake recommendations vary under different conditions. Intake of 350 μg is required to maintain plasma homocysteine levels, 650 μg for those with elevated plasma homocysteine, about 400 μg for women planning to become pregnant and 4000 μg for those with history of neural tube defect affected pregnancy. This raises the question whether the folate intake is adequate for the general population, particularly in the vulnerable groups or whether there is a need for scientists to take a fresh view of the requirements, recommended dietary intakes, and consider intervention measures which will have impact on the folate nutritional status. The recommendations should provide a margin of safety to allow for decreased intake, increased requirements, individual variability and bioavailability of natural food folates. The folate intake and nutriture in relation to India and other developing countries needs careful consideration to reduce anemia, neural tube defects and possibly impact on the high incidence of cardiovascular diseases.
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Duthie, Susan J. "Folic-acid-mediated inhibition of human colon-cancer cell growth." Nutrition 17, no. 9 (September 2001): 736–37. http://dx.doi.org/10.1016/s0899-9007(01)00595-0.

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Dissertations / Theses on the topic "Folic acid in human nutrition"

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Strahley, Monica L. "Nutrition awareness of folic acid among Thai women." Virtual Press, 2003. http://liblink.bsu.edu/uhtbin/catkey/1259752.

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The objective of this study was to determine Thai women's nutrition awareness of folic acid and its role in the prevention of neural tube defects. Three hundred and two Thai women between 18-45 years completed a 30 itemized survey. There was a significant lack of nutrition awareness of folic acid. Many women (n= 274; 91.9%) had not heard of neural tube defects (NTD) and only 8.1 % (n=24) had heard of spina bifida/NTD. More than 50% (n=176) were unaware of NTD. Only 11.6% of the women (n=35) thought consuming vitamins during pregnancy would reduce the risk of birth defects. More than 80% of the women reported the best time to take folic acid supplement was during pregnancy. Less than 20% of the women indicated taking folic acid supplement before or after pregnancy. In this population, nutrition awareness of folic acid was minimal.
Department of Family and Consumer Sciences
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Holmes, William Barnett. "Characterization of yeast methenyltetrahydrofolate synthetase and study of the requirement for formylation of initiator tRNAfmet in yeast mitochondria /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008353.

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Thesis (Ph. D.)--University of Texas at Austin, 2001.
"Fmet" after tRNA in title is superscript. Vita. Includes bibliographical references (leaves 102-119). Available also in a digital version from Dissertation Abstracts.
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Tshitaudzi, Gilbert Tshimangadzo. "Nutritional status of pregnant women (under 20 years of age) with special emphasis on iron and folic acid status." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53529.

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Thesis (Mnutr)--University of Stellenbosch, 2003.
ENGLISH ABSTRACT: Pregnancy and growth have been found to have a detrimental effect on the micronutrient status of adolescent girls. Dietary studies in adolescents have shown serious shortfalls in their dietary iron and folate intake. The competition for nutrients between the fetus and a pregnant adolescent may carry the risk of complications such as intrauterine growth retardation, pre-eclampsia, both maternal and fetal intrapartum mortality, the increased risk of birth injuries and low birth weight. The aim of the study was to assess the nutritional status of rural black, pregnant teenagers attending the antenatal clinic at Siloam Hospital in the Limpopo Province, with special emphasis on iron and folic acid intake, and evaluation of the newborn babies in terms of weight status and neural tube defects. The nutritional status was determined in 40 pregnant and 40 non-pregnant adolescent girls. The pregnant girls were selected during their first visit to the antenatal clinic, and the non-pregnant girls were selected from nearby schools. The demographic and dietary history questionnaires were used to collect information from the subjects. The dietary intake of the subjects was collected by the completion of a pre-tested quantified food frequency questionnaire. The anthropometric questionnaire was used to get information from the pregnant adolescents and the control group. The infant anthropometric measurements questionnaire provided information on the infant and the outcome of birth. Blood was collected from the pregnant adolescent girls and the control subjects. Anaemia was observed in 57.5% of the pregnant and 27.5% of the non-pregnant adolescents (haemoglobin AFRIKAANSE OPSOMMING: Daar is bevind dat swangerskap en groei 'n nadelige effek het op die mikronutriëntstatus van vroulike adolessente. Dieetstudies in adolessente het ernstige tekortkominge in dieetyster- en folaatinnames getoon. Die kompetisie vir nutriente tussen die fetus en die swanger adolessent kan verantwoordelik wees vir komplikasies soos intra-uterine groeivertraging, preeklampsie, verhoogde mortaliteit van beide moeder en baba tydens kraam, 'n verhoogde risiko vir geboortebeserings en lae geboortegewig. Die doel van die studie was om die effek van voedingstatus by swart, swanger tieners by die voorgeboortekliniek in Siloam Hospital in die Limpopo-provinsie te bepaal, met spesifieke verwysing na die yster- en foliensuurinname, asook die evaluering van die pasgebore babas in terme van gewig en neurale buis defekte. Die voedingstatus van 40 swanger en 40 nie-swanger adolessente meisies IS bepaal. Die swanger meisies is ewekansig geselekteer gedurende die eerste besoek aan die voorgeboortekliniek , en die nie-swanger meisies is geselekteer by nabygeleë skole. Die demografiese en dieetgeskiedenisvraelyste is gebruik om inligting van die proefpersone in te samel. Voorafgetoetste gekwantifiseerde voedselfrekwensie vraelyste is gebruik om die voedselinname van proefpersone te bepaal. Antropometriese vraelyste is gebruik om antropometriese inligting van die swanger adolessente en die kontrole groep. Die antropometriese vraelys vir babas is gebruik om inligting ten opsigte van die baba aan te teken asook die verloop van die swangerskap. Bloedmonsters is van die swanger tieners en die kontrole groep ingesamel. Anemie is waargeneem by 57.5% van die swanger en 27.5% van die nie-swanger adolessente (hemoglobien
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Leininger, Dawn. "Consumption and knowledge of folate among college students /." View online, 1998. http://repository.eiu.edu/theses/docs/32211130891409.pdf.

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Stahlhut, Lynn M. "Folic acid : consumption and knowledge for the prevention of neural tube defects among college-aged women /." View online, 2004. http://repository.eiu.edu/theses/docs/32211131180526.pdf.

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Hersey, Sarah Koltenbah. "The effect of folate intake and extended lactation on material serum, red cell and milk folate status." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1041901.

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Maternal folate intake and levels of folate in milk, serum and red cells were assessed in 57 healthy, lactating women, ages 22-38 years, throughout early (0-6 months) and later (7-23 months) lactation. Average maternal folate intake from diet alone was 212 µg/day or 78.5% RDA (1989) and mean total folate intake from diet and supplements was 314% RDA (878 µg/day) at 0-6 months and 238% RDA (620 µg/day) at >6 months. Human milk folate was sufficient to meet the RDA (1989) for infants. Milk folate was not related to maternal folate intake, maternal serum or red cell folate and was unaffected by extended lactation (7-23 months), perhaps at the expense of maternal folate stores. Compared with early lactation, serum folate decreased (p=0.0004) and red cell folate tended to decrease (p=0.08) in later lactation and were both increased by folate supplementation (p < 0.001).Level of folic acid supplementation appeared to predict red cell folate concentration. An average of 884 µg supplemental folate/day was associated with red cell folate levels >400 ng/mL, which have previously been reported as optimal for prevention of folateresponsive neural tube defects. The addition of an 880 µg/day folic acid supplement to the diet of lactating women may raise red cell folate concentrations of lactating women to protective levels.
Department of Family and Consumer Sciences
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Morkel, Ryan Andrew. "Vitamin B12 and folate enrichment of kefir by Propionibacterium freudenreichii and Streptococcus thermophilus strains." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2339.

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Thesis (MTech (Food Technology))--Cape Peninsula University of Technology, 2016.
In South Africa malnutrition exists due to inadequate dietary intake of micronutrients which is one of the major causes of vitamin deficiencies leading to disease. The treatment of malnutrition over the past years has been a considerable burden on the South African economy. Therefore, food fortification is one of the current strategies used to minimize malnutrition by increasing the nutritional value of staple foods. Commercial dairy products and pharmaceutical nutritional products (food supplements) in South Africa have been developed and produced for affluent consumers. Hence the need to develop an affordable fortified dairy product for the majority of South Africans prompted this study aimed at using a “naturally” fortified kefir beverage with vitamin B12 and folate to increase B-vitamins levels. Since Propionibacterium freudenreichii and Streptococcus thermophilus are known to be good producers of vitamin B12 and folate, respectively, and propionibacteria has the ability to grow symbiotically in the presence of lactic acid bacteria, the inclusion of these organisms with the kefir grains was an achievable objective. In order to conduct the analysis of vitamin B12 and folate in the samples, sample extraction and HPLC assay techniques were developed. The extraction of vitamin B12 and folate were achieved by using KCN extraction buffer and the trienzymatic method, respectively. The samples were also subjected to purification and concentration using solid phase extraction for optimum results. All standards and samples were flushed with nitrogen gas and stored for a maximum of 2 weeks at –20°C to prevent B-vitamin deterioration. The HPLC assembly for the vitamin B12 analysis included a Luna C18 column and a diode array detector (DAD) for the detection and quantification. For the folate analysis it included a Zorbax SB-C18 and Luna C18 columns in tandem and the fluorescence detector (FLD) was used for the detection and quantification of THF, 5-CH3-THF and 5-CHO-THF, while the DAD was used for PGA and pteroyltri-γ-L-glutamic acid concentration in the samples.
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Kilker, Katie P. "Is Knowing Half the Battle? An Examination of the Relationship between Folic Acid Knowledge and Awareness and Daily Supplementation with Folic Acid among 18 to 24 year old Women Who are Not Contemplating Pregnancy." unrestricted, 2007. http://etd.gsu.edu/theses/available/etd-07232007-152434/.

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Thesis (M.P.H.)--Georgia State University, 2007.
Title from file title page. Russ Toal, committee chair; Catherine McCarroll, Joseph Mulinare, committee members. Electronic text (83 p. : ill.) : digital, PDF file. Description based on contents viewed Jan 8, 2008. Includes bibliographical references (p. 79-83).
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Strålsjö, Lena. "Folates in berries : evaluation of an RPBA method to study the effects of cultivar, ripeness, storage and processing /." Uppsala : Dept. of Food Science, Swedish Univ. of Agricultural Sciences, 2003. http://epsilon.slu.se/a368.pdf.

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Johansson, Madelene. "Analytical and nutritional aspects of folate in cereals /." Uppsala : Dept. of Food Science, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/200507.pdf.

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Books on the topic "Folic acid in human nutrition"

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Frances, Picciano Mary, Stokstad E. L. Robert, Gregory Jesse F, and American Chemical Society. Food and Nutritional Biochemistry Subdivision., eds. Folic acid metabolism in health and disease. New York: Wiley-Liss, 1990.

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Bailey, Lynn B. Folate in health and disease. 2nd ed. Boca Raton: Taylor & Francis, 2010.

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1948-, Bailey Lynn B., ed. Folate in health and disease. New York: M. Dekker, 1995.

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Canada, Canada Health. Why all women who could become pregnant should be taking folic acid. [Ottawa]: Health Canada, 2002.

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J, Massaro Edward, and Rogers John M, eds. Folate and human development. Totowa, N.J: Humana Press, 2002.

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Kurtzweil, Paula. How folate can help prevent birth defects. [Rockville, MD: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, 1996.

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Kurtzweil, Paula. How folate can help prevent birth defects. [Rockville, MD: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, 1997.

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Folic acid and the prevention of disease: Report of the Committee on Medical Aspects of Food and Nutrition Policy. London: Stationery Office, 2000.

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Daigaku, Joshi Eiyō, ed. Joshi Eiyō Daigaku no 100-sai made bokenai kenkō reshipi: Ninchishō, nōkōsoku, shinkin kōsoku, utsu o fusegu! Tōkyō: Sekai Bunkasha, 2012.

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Craig, Peta. Mandatory folic acid and iodine fortification in Australia and New Zealand: Baseline report for monitoring. Canberra: Australian Institute of Health and Welfare, 2011.

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Book chapters on the topic "Folic acid in human nutrition"

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Winter, Jerrold. "Folic Acid." In True Nutrition, True Fitness, 155–62. Totowa, NJ: Humana Press, 1991. http://dx.doi.org/10.1007/978-1-4612-0479-4_13.

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Czeizel, Andrew E. "Folic Acid/Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects and Preterm Birth." In Preventive Nutrition, 643–72. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-542-2_25.

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Wald, N. J. "Folic Acid and Neural Tube Defects." In Forum of Nutrition, 22–33. Basel: KARGER, 2000. http://dx.doi.org/10.1159/000059459.

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Beresford, Shirley A. A., and Arno G. Motulksy. "Homocysteine, Folic Acid, and Cardiovascular Disease Risk." In Preventive Nutrition, 191–220. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1007/978-1-59259-880-9_8.

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Beresford, Shirley A. A., and Carol J. Boushey. "Homocysteine, Folic Acid, and Cardiovascular Disease Risk." In Preventive Nutrition, 193–224. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-4757-6242-6_11.

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Mikkelsen, Kathleen, and Vasso Apostolopoulos. "Vitamin B12, Folic Acid, and the Immune System." In Nutrition and Immunity, 103–14. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-16073-9_6.

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Czeizel, Andrew E. "Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects." In Preventive Nutrition, 603–27. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1007/978-1-59259-880-9_24.

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Czeizel, Andrew E. "Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects." In Preventive Nutrition, 351–71. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-4757-6242-6_19.

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Paradisi, Giancarlo, Francesca Ianniello, Francesca Basile, Cristina Di Cesare, Lorena Quagliozzi, Laura Donati, and Alessandro Caruso. "Effect of Folic Acid Supplementation in Postmenopausal Women." In Nutrition and Diet in Menopause, 225–39. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-373-2_17.

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Keating, Elisa, Fátima Martel, and João R. Araújo. "Folic Acid and Gestational Diabetes: Foundations for Further Studies." In Nutrition and Diet in Maternal Diabetes, 465–77. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56440-1_35.

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Conference papers on the topic "Folic acid in human nutrition"

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Akca, Emine Erdağ, Özlem Çağındı, and Ergun Köse. "The Importance of Cereal Based Foods to Prevention of Iron Deficiency." In 6th International Students Science Congress. Izmir International Guest Student Association, 2022. http://dx.doi.org/10.52460/issc.2022.025.

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Iron is vital for almost every organism, due to its role in a wide range of metabolic processes. For the human body, it contributes to crucial activities, especially haemoglobin synthesis and oxygen transport. Iron deficiency anaemia occurs when iron stores release inadequate amount of iron [1; 2; 3]. However, basic strategies can be used effectively in the prevention of iron deficiency and related anaemia. Although the applicability of these strategies mostly depends on the health infrastructure, the economy of the countries and people's access to resources, it is stated that food fortification is one of the most cost-effective methods [3; 4]. Cereals and pulses are often preferred in food fortification studies as they form the basis of daily nutrition. Around the world, 85 countries have already made it mandatory to fortify wheat flour (and corn/rice) with iron or folic acid [4; 5]. In this study, theoretical information and recent developments on the subject were evaluated in detail with a comprehensive literature review about the role of grain-based products in the prevention of iron deficiency and iron deficiency anaemia. Additionally, food fortification, complex food matrix, bioaccessibility/bioavailability, interaction with sensory and organoleptic properties and aimed to gain a current perspective for future studies on the selection of iron forms.
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Brenna, Tom. "Human Nutrition and Health Viewed Through the Diversity of Fatty Acid Structures." In Virtual 2021 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2021. http://dx.doi.org/10.21748/am21.231.

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Bailey, H. M., E. P. Berg, and H. H. Stein. "Protein quality evaluation in processed human foods by the digestible indispensable amino acid score methodology." In 6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition. The Netherlands: Wageningen Academic Publishers, 2019. http://dx.doi.org/10.3920/978-90-8686-891-9_130.

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Birch, Eileen, Dennis Hoffman PhD, David Birch, Ricardo Uauy, Mark Bane, Yolanda Castañeda, and Claude Prestidge. "Visual Acuity Development of Term Infants Fed ω3 Long Chain Polyunsaturated Fatty Acid (LCPUFA) Supplemented Formula." In Vision Science and its Applications. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/vsia.1996.tha.1.

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While breast-feeding provides optimal nutrition for healthy infants, maternal health, social, and/or economic factors may constrain a mother's ability to provide human milk. Formula feeding provides a safe and effective alternative source of nutrition. In response to ongoing research, formula composition is revised to more closely mimic human milk in providing essential nutrients to support optimal growth and development. During the last decade, supplementation of infant formula with ω3 long chain polyunsaturated fatty acids (LCPUFAs) has been a major focus of infant nutrition research. ω3 LCPUFAs, particularly docosahexaenoic acid (DHA), are found in extremely high concentration in photoreceptor outer segments and in cerebral cortex.
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Schlicht, K., C. Knappe, C. Geisler, K. Türk, D. Schulte, K. Hartmann, S. Waschina, S. Brodesser, S. Schreiber, and M. Laudes. "Effects of Bile acid levels on gut microbial community metabolic processes, microbiome diversity and human metabolism and nutrition status." In Diabetes Kongress 2021 – 55. Jahrestagung der DDG. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1727449.

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Me´ndez-Rojas, Miguel A., Claudia Cravioto Guzman, and Oscar Arias-Carrion. "Synthesis and Chemical Functionalization of Ferromagnetic Nanoparticles to Manipulate Stem Cells Using External Magnetic Fields." In ASME 2007 5th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2007. http://dx.doi.org/10.1115/icnmm2007-30188.

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The human brain is able to respond to several situations that promotes neural survivance, growth and neuronal cells regeneration. The potential of stem cells from the subventricular zone to be used for neuronal cell substitution has been widely studied. However, migration of endogen or transplanted cells is random, not efficient and with a very low survivance rate. The use of ferromagnetic nanoparticles may be of interest to guide the stem cells to the desired site using external fields. In this project, we have synthesized ferromagnetic nanoparticles (magnetite) with an average diameter of 10–12 nm, and functionalized with folic acid-flourosceine (with an average yield of 60–70%) in order to induce their entry into rat neuronal precursor cells in vivo and in vitro. The efficiency of cellular incorporation was low in vitro, observing clustering of the nanoparticles at the cytoplasm membrane. During the in vivo tests, no incorporation of nanoparticles was detected. Several results and perspectives are discussed in this work.
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Lemiasheuski, V. O., M. M. Ozcan, and K. S. Ostrenko. "MILK AND MILK BY PRODUCTS AND ALTERNATiVE ASSESSMENT METHODS." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-225-228.

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There are always byproducts and residues in the processing of raw material into final crops. These constitute parts of the original material that are not evaluated. In the dairy industry, various residues remain in the processing of the raw material milk into crops. “Skimmed milk, cheese water and buttermilk” are left over from the separation of milk into cream, processing into cheese and butter and making butter from yogurt. In terms of utilizing these substances, preventing the loss of nutritionally important nutrients, and also using them in animal and human nutrition, commercial products such as glue, oil paint, artificial fabric contain raw materials such as acetone, alcohol, acid. They are of great importance in terms of food supply and economy.
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Brenna, J. Thomas. "How does knowledge of omega-3 fatty acids inform the food system?" In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/cfsw6115.

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With over 40,000 studies published, omega-3s are among most studied compounds in all of biology. We know a great deal about their metabolism, genetics, and nutrition that has not been translated into the global industrial food system. Development and maintenance of the human and general neural function depends on a balanced nutritional supply of omega-6 and omega-3 PUFA. Omega-3s are the most labile of oil components, leading to rancidity during processing and limiting shelf-life. Recent research has clarified the roles of the human FADS1 and FADS2 genes as key to conversion of precursor alpha-linolenic acid (ALA) to bioactive products eicosapentaenoic acid (EPA) and docosahexaenoic acid ((DHA). FADS2 is a promiscuous desaturase enzyme that inserts double bonds at the 4, 6, and 8 positions and acts on at least 16 substrates including numerous saturated fatty acids, while FADS1 is highly specific to 5 desaturation and C20 substrates. FADS gene polymorphisms lead primarily to modulation of circulating arachidonic acid in free living humans, which is likely to influence omega-3 requirements through biochemical competition at many levels. Natural, pre-industrial diets are high in saturated and monounsaturated fats, and supply dietary essential fatty acids at less than 4% of calories. Such diets support endogenous EPA and DHA biosynthesis at relatively robust levels, while diets high in PUFA inhibit EPA/DHA tissue accretion and create a metabolic demand. Recent recommendations focus on gently processed healthy foods rich in shortfall nutrients despite high saturated fat content have been advanced. Dietary intake of EPA and DHA have effects specific to each fatty acid, and both are more efficiently incorporated into tissue than when derived from precursors. Current evidence is that both are required for optimal health.
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Gürel, Duygu Benzer, and Özlem Çağındı. "The Effect of Functional Foods on Mood, Cognitive Function and Well-Being." In 6th International Students Science Congress. Izmir International Guest Student Association, 2022. http://dx.doi.org/10.52460/issc.2022.023.

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The concept of food as medicine is not new. The use of foods to prevent and/or treat certain diseases can be found in ancient drawings and writings. The most famous statement came from Hippocrates, who said “Let food be thy medicine.” It is the position of the Academy of Nutrition and Dietetics to recognize that although all foods provide some level of physiological function, the term, “functional foods” is defined as whole foods along with fortified, enriched, or enhanced foods that have a potentially beneficial effect on health when consumed as part of a varied diet regularly at effective levels based on significant standards of evidence. The most prominent results indicated that high total intake of fruits and vegetables, and some of their specific subgroups including berries, citrus, and green leafy vegetables, may promote higher levels of optimism and self-efficacy, as well as reduce the level of psychological distress, ambiguity, and cancer fatalism, and protect against depressive symptoms. Flavonoids are a class of organic polyphenolic compounds found in varying concentrations in plant-based whole foods such as berries, tea, cocoa, soybeans, and grains. Recent studies suggest that flavonoids can be beneficial to both cognitive and physiological health. As such, long term chronic supplementation with flavonoids has been investigated extensively, particularly concerning cognitive ageing and related neurodegenerative disorders. Less attention has been given to the acute effect of flavonoids on cognitive outcomes, within the immediate 0–6 h post ingestion. Therefore, the general recommendation to consume at least 5 portions of fruit and vegetables a day may be beneficial also for mental health. Immediate cognitive enhancement is often desirable in academic and work environments, such as during an exam or assessment. Besides, support a positive role for the nutrients EPA, DHA, magnesium, alpha-tocopherol, and folic acid, either alone or in combination with drugs, in the preservation of normal brain function and mental well-being. In this study, the effects of consumption of some functions on mood, cognitive function and mental health were investigated. Scientific findings support the combination of micro and macronutrients in a balanced and varied diet along with a healthy lifestyle for the maintenance of normal brain function, improvement of mental abilities, concentration, memory and alertness. Food components actively participate in the generation of nerve impulses by influencing neurotransmitters that activate different parts of the brain, thereby regulating our mental abilities, emotions and mood.
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Uđilanović, M. Z., S. D. Vasiljević, and Z. S. Šimšić. "QUANTIFICATION OF ESSENTIAL ELEMENTS IN PAPAVER RHOEAS L. AND PAPAVER SOMNIFERUM." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.133u.

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Plants are very important for proper human nutrition, so the content of essential elements was investigated in two poppy species. Essential elements such as Ca, Na, K, Mg, Fe, Cu, Co, Mn, Mo and Zn play a vital role in various biological processes. Samples of roots, stems, leaves and seeds of Papaver rhoeas L. and Papaver somniferum were acid dissolved and analyzed by inductively coupled plasma optical emission spectrometer (ICP-OES). The highest concentration of Ca was contained in leaf samples ML1 and ML2 with values of 38618.90 and 33320.15 mg/kg, the root of Papaver rhoeas L. had the highest concentration of Na with a value of 1651.07 mg/kg, while the leaf had the highest concentration of Mg of 4400.04 mg/kg. The leaf Papaver somniferum contains the highest concentration of K with a value of 61595.90 mg/kg, the root samples MK1 and MK2, both poppies had the highest Fe of 1254.21 and 1620.16 mg/kg. Seeds of both poppies, Papaver rhoeas L. and Papaver somniferum, contain the highest concentration of Cu with values of 30.57 and 22.20 mg/kg, Mn with values of 71.99 and 58.10 mg/kg and Zn with values of 76.99 and 82.09 mg/kg. The Co content in all samples was low.
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