Dissertations / Theses on the topic 'Folate'
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Chow, Lai-man, and 周勵文. "Folate receptor alpha and reduced folate carrier in endometrialcancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45153188.
Full textAmanna, Karen Ruggio. "Folate status and milk folate concentration in lactating women." Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-11182008-063632/.
Full textTsang, Hiu-may, and 曾嬈媚. "Folate receptor alpha and reduced folate carrier in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4467059X.
Full textScurachio, Regina Spricigo. "Fotodegradação de folatos sensibilizados por flavinas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-17032011-155300/.
Full textFolic acid, the most stable among folate, is recommended as prevention and it is found in supplementation and fortified foods such as milk and dairy products. The folate can react with singlet-excited state of riboflavin, 1kq= 4.8·1010 L·mol-1·s-1, as determined by steady-state fluorescence quenching, and with triplet-excited state of riboflavin in a slower reaction with 3kq= 4.8·108 L·mol-1·s-1, as determined by laser flash photolysis and transient absorption spectroscopy, verifying that both the processes are competitive and they are near limited diffusion. The kinetic preference depends on the matrix food. The quantum yield for the solution of riboflavin and folate prepared in aqueous and deuterated solvents and in anaerobic and aerobic medium showed the prevalence of the mechanism Type I. The cyclic voltammetry showed an irreversible two-electron anodic process for folate (E = 1.14 V vs. NHE). The main products of folate photodegradation sensitized by riboflavin were identified by LC-IT-MS/MS as: pterin-6-carboxylic acid, p-aminobenzoyl-L-glutamic acid and oxaziridine derivative of folic acid, as confirming chemical quenching of the triplet-excited state of riboflavin by electron transfer with subsequent oxidative cleavage between N(10) and C(9) in folic acid.
Lawrence, Scott Alan. "The Mechanism of Mitochondrial Folate Transport by the Mitochondrial Folate Transporter." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2066.
Full textScott, D. A. "Folate metabolism in Leishmania." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375461.
Full textSharp, Linda. "Folate and genetic variation in folate metabolism in the aetiology of colorectal cancer." Thesis, University of Aberdeen, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430975.
Full textAshfield-Watt, Pauline A. L. "Folate, homocysteine and cardiovascular disease : an investigation of dietary strategies to increase folate status." Thesis, Cardiff University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444123.
Full textRudd, Michelle. "Folate : friend or foe? : an investigation into the opposing roles of folate in glioma." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/20737/.
Full textDíaz, de la Garza Rocío Isabel. "Folate engineering in tomato fruit." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0017287.
Full textCollin, Simon Michael. "Folate metabolism and prostate cancer." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541606.
Full textJones, Marc. "Folate binding protein : partial characterisation of bovine milk folate binding protein, includings its ligand binding /." [St. Lucia, Qld], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18263.pdf.
Full textArkbåge, Karin. "Vitamin B₁₂, folate and folate-binding proteins in dairy products : analysis, process retention and bioavailability /." Uppsala : Dept. of Food Science, Swedish Univ. of Agricultural Sciences, 2003. http://epsilon.slu.se/a430.pdf.
Full textOchong, Edwin Omondi. "Novel contributions to understanding the mechanism of folate transport and anti-folate resistance in Plasmodium falciparum." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501706.
Full textAnukul, Nampeung. "Genetic manipulation of folate in rice." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/12962/.
Full textRobson, Claire. "Biochemical probes for folate-metabolising enzymes." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240965.
Full textMcKillop, Derek John. "Stability and bioavailablity of food folate." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274093.
Full textElnakat, Hala. "Regulation of Folate Receptor Raft Recycling." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1174569209.
Full textMcEligot, Archana Jaiswal. "Relationships between smoking, homocysteine and folate /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3029638.
Full textHersey, Sarah Koltenbah. "The effect of folate intake and extended lactation on material serum, red cell and milk folate status." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1041901.
Full textDepartment of Family and Consumer Sciences
Shinohara, Elvira Maria Guerra. "Prevalência de anemia em gestantes de primeira consulta em centros de saúde do estado no Subdistrito de Paz do Butantã, Município de São Paulo." Universidade de São Paulo, 1989. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-27032008-142216/.
Full textHussien, M. "Folate status, genetic damage and breast cancer." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269044.
Full textAbilgos, Ramos Riza. "Folate profiling in wild and transgenic rice." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/12870/.
Full textOrdakowski, Amy L. "Folate Status and Supplementation in the Horse." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/28568.
Full textPh. D.
Sudimack, Moseley Jennifer Jo. "Targeted drug delivery via the folate receptor /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486459267519529.
Full textAndrews, Shannon. "FOLATE CONJUGATED DENDRIMERS FOR TARGETED ANTICANCER THERAPY." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3497.
Full textMoradi, Emilia. "Folate-mediated macromolecule delivery across the epithelium." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/27899/.
Full textSurdhar, Mohinderjeet S. "Folate metabolism in the female weanling rat." Thesis, Aston University, 1987. http://publications.aston.ac.uk/14503/.
Full textMcNulty, Breige. "Folate status during pregnancy - implications for dietary recommendations for folate and related B-vitamins in women of reproductive age." Thesis, University of Ulster, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529578.
Full textColapinto, Cynthia. "Examining the Folate Status of Canadians: An Analysis of the Canadian Health Measures Survey to Assess and Guide Folate Policies." Thesis, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26103.
Full textReid, Deborah Jane. "Folate and zinc status of chronic hemodialysis patients." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29786.
Full textLand and Food Systems, Faculty of
Graduate
Miller, Pamela N. "The effect of folate deficiency on mammalian pregnancy." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/34165.
Full textJohansson, Madelene. "Analytical and nutritional aspects of folate in cereals /." Uppsala : Dept. of Food Science, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/200507.pdf.
Full textPatel, Harshila. "The compartmentalization of folate metabolism in mammalian cells /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85091.
Full textAlthough the folate pathways are compartmentalized, the mitochondrial folate pathway makes an important contribution to total cellular folate metabolism. Mouse fibroblasts that have a completely inactivated NMDMC gene are glycine auxotrophs. Furthermore, growth of these Nmdmc-/- cell lines is stimulated by supplementation with formate or hypoxanthine. These cell lines also show enhanced incorporation of radioactivity into DNA from formate as compared to serine, demonstrating that formate is a preferred one-carbon donor for the Nmdmc-/- cell lines. This indicates that NMDMC is required for optimal purine biosynthesis during periods of rapid cellular proliferation such as embryogenesis and tumorigenesis. The rescue of these Nmdmc-/- cell lines with NMDMC expression reversed the glycine auxotrophy and the formate to serine incorporation ratio reverted toward the wild type ratio. The rescue of these Nmdmc-/- cell lines with the NAD-dependent monofunctional dehydrogenase activity also reversed the glycine auxotrophy but these cell lines did not grow as well as the NMDMC-rescued cell lines. This indicates that although the cyclohydrolase activity is not required in the mitochondria, the rate of 10-formyl-THF production is not optimal in its absence. Furthermore, when these Nmdmc-/- cell lines were rescued with the expression of the NADP-dependent DCS in the mitochondria there was reversal of the glycine auxotrophy as well, indicating that the NAD cofactor specificity of the mitochondrial methylenetetrahydrofolate dehydrogenase is not absolutely essential to maintain the flux of one-carbon metabolites.
Rios-Orlandi, Ethel Marie. "Kinetic properties of two folate-dependent dehydrogenase-hydrolases." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75844.
Full textBhattacharya, Shiladitya. "Novel folate amphiphile conjugates for targeted drug delivery." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2360.
Full textAlvarez, Mary Allison. "Pyridinium Bis-retinoids: Extraction, Synthesis, and Folate Coupling." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/8870.
Full textBaker, Bernadette. "The effect of folate deficiency on placental function." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-effect-of-folate-deficiency-on-placental-function(2e4035d8-ab44-4f5c-a92b-f851f65a3609).html.
Full textAlvarez, Mary Allison Lawyer. "Pyridinium bis-retinoids : extraction, synthesis, and folate coupling /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1745.pdf.
Full textLeininger, Dawn. "Consumption and knowledge of folate among college students /." View online, 1998. http://repository.eiu.edu/theses/docs/32211130891409.pdf.
Full textÖhrvik, Veronica. "Folate bioavailability in vitro experiments and human trials /." Uppsala : Dept. of Food Science, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200963.pdf.
Full textPereira, Perla Menezes. "Consumo de cobalamina e folato por gestantes: relação com o metabolismo da homocisteína e com os polimorfismos nos genes da metionina sintase, metilenotetraidrofolato redutase e metionina sintase redutase." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04042007-164324/.
Full textThe inadequate intake of cobalamin and folate associated to polymorphisms in key-enzyme genes of homocysteine can worsen comorbidities related to the deficiency of these vitamins. The aims of this study were to evaluate the intake of cobalamin, foiate and vitamin 86 by pregnant women through three 24-hour dietary recaIl (IR24h); to assess the correlation between serum concentrations of folate, cobalamin, methionine, S-adenosilmethionine (SAM), S-adenosilhomocysteine (SAH), total homocysteine (tHcy) and methylmalohic acid (MMA)towards vitamins and proteins intaked by women, to analyze association between MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G polymorphisms and changes on vitamin and metabolites concentration, and to determine the nutritional and genetic determinants during a gestational period. 73 pregnant women participated in this study, with gestational ages of 16,28 and 36 weeks, onto whom were applied three IR24h to each woman, being one in each gestational age. Serum concentrations of cobalamin, foiate and red blood cell foiate, total homocysteine, methionine, MMA, SAM and SAH were evaluated. The polymorphisms of MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRRA66G were performed by PCR-RFLP. It was observed that folate intake was low in relationship to recommended value for pregnant women of 600 µg/day. Cobalamin intake was less than the one found in literature. Vitamin 86 and total protein intake was similar to the one found in literature. Serum Cbl concentrations were directly related to protein intake. MMA concentrations were in,verselycorrelated to cobalamin intake, to total proteins intakes and mounth per capita income. There were reduction of serum cobalamin concentration and enhance of MMAthroughout pregnancy weeks, being observed higher serum concentration of MMAamongst women that intaked less cobalamin. There was no association between MTHFRA1298Cand RRA66Gpolymorphism and the change in vitamins and metabolites concentrations. The women carrying allele 2756G for MTR polymorphism presented lesser serum methionine concentrations and alieie 677T for MTHFR C677T had less concentration of red blood cell folate. The red blood cell folate concentrations, intake of total proteins, serum creatinine concentrations and intake of vitamin 86 were eterminant of tHcy concentration. Serum creatinine was responsible for SAMconcentrations variability. Higher concentrations of serum foiate and lesse r concentrations of serum creatinine were responsible for the enhance of SAM/SAHvalues. The higher concentrations of MMAwere attributed to lesse r cobalamin intake, to lower per capita income and to lesser seruro concentration Df coba}amin. ConcJusions: lo/ate intake was less than ha(f of recommended amount, and cobalamina intake reached the recommended amount, however this amount was not enough to keeping the maternal metabolism. The poly~orphisms were not associated to low vitamin intake for explaining the changes Inserum concentrationsof tHcy,SAM,SAM/SAHand MMA.
Brockton, Nigel Trevellyan. "Genetic polymorphisms in folate and xenobiotic metabolism and susceptibility to colorectal cancer." Thesis, University of Aberdeen, 2003. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU496469.
Full textGonzalez-Jorge, Sabrina. "Dissecting the genetic control of folate homeostasis in plants." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491008.
Full textCastelazo, Anahi Santoyo. "Comprehensive folate profiling in plants using LC-MS/MS." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508152.
Full textMehrshahi, Payam. "Characterising the functional importance of folate polyglytamylation in plants." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478929.
Full textDoshi, Sagar Navinchandra. "Homocysteine, folate and endothelial function in coronary heart disease." Thesis, Cardiff University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444121.
Full textDewar, Simon. "Folate transport and drug resistance in the African trypanosome." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/816f1fc5-dd5a-41d9-83a5-45e825f0af06.
Full textPadmanabhan, Nisha. "The biological and molecular effects of abnormal folate metabolism." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708242.
Full textZilliox, Trish, and Silva Vanessa da. "Folate & Folic Acid- Healthy Moms Mean Healthy Babies." College of Agriculture, University of Arizona (Tucson, AZ), 2017. http://hdl.handle.net/10150/625289.
Full textBefore they may even know they are pregnant; women’s bodies and their level of folate play a critical role in preventing certain birth defects, specifically neural tube defects (NTDs). NTDs are birth defects in the brain, spinal cord, or spine. Considered ‘one of the most important public health discoveries of this century’ is that daily supplemental folic acid taken before becoming pregnant significantly reduces the risk of NTDs (1). In 1998, the United States made sweeping efforts that fortified cereal grains with folic acid to ensure all Americans consume adequate amounts of this vitamin. So what exactly is folate? What are the functions of this vitamin? What foods have high levels of folate and what is the recommended daily intake? This article will answer these questions and will go on to explain folic acid fortification and the impact fortification has had on the incidence of NTDs in Arizona.