Log in

Relevant bibliographies by topics / Folate

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers
Reports

Academic literature on the topic 'Folate'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Folate.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Folate"

1

McNulty, Helene, and Kristina Pentieva. "Folate bioavailability." Proceedings of the Nutrition Society 63, no. 4 (November 2004): 529–36. http://dx.doi.org/10.1079/pns2004383.

Full text

Abstract:

The achievement of optimal folate status to prevent neural-tube defects, and possibly other diseases, is hindered by the well-recognised incomplete bioavailability of the natural folates found in foods compared with the synthetic vitamin, folic acid. Folate bioavailability from different foods is considered to be dependent on a number of factors, including the food matrix, the intestinal deconjugation of polyglutamyl folates, the instability of certain labile folates during digestion and the presence of certain dietary constituents that may enhance folate stability during digestion. There is conflicting evidence as to whether the extent of conjugation of polyglutamyl folate (in the absence of specific inhibitors of deconjugation in certain foods) is a limiting factor in folate bioavailability. Estimates of the extent of lower bioavailability of food folates compared with folic acid (relative bioavailability) show great variation, ranging anywhere between 10 and 98%, depending on the methodological approach used. The lack of accurate data on folate bioavailability from natural food sources is of particular concern in those countries in which there is no mandatory folic acid fortification, and therefore a greater reliance on natural food folates as a means to optimise status. Apart from the incomplete bioavailability of food folates, the poor stability of folates in foods (particularly green vegetables) under typical conditions of cooking can substantially reduce the amount of vitamin ingested and thereby be an additional factor limiting the ability of food folates to enhance folate status. A recent workshop convened by the Food Standards Agency concluded that gaining a better understanding of folate bioavailability in representative human diets is a high priority for future research.

APA, Harvard, Vancouver, ISO, and other styles

2

Cossins, Edwin A. "Canadian Society of Plant Physiologists Gold Medal Review / Synthèse médaillée d'or de la Société canadienne physiologie végétaleThe fascinating world of folate and one-carbon metabolism." Canadian Journal of Botany 78, no. 6 (June 1, 2000): 691–708. http://dx.doi.org/10.1139/b00-061.

Full text

Abstract:

Folate was first isolated from spinach leaves in 1941 and characterized as pteroylglutamic acid. Although plants, fungi, and bacteria synthesize folate de novo, animal cells lack key enzymes of the folate biosynthetic pathway and a dietary source of folate is required for normal growth and development. Folates have importance in human nutrition, health, and disease, and antifolate drugs are commonly used in cancer chemotherapy. In the majority of living cells folates occur as one-carbon substituted tetrahydropteroylpolyglutamate derivatives. These folates donate one-carbon groups during the synthesis of purines, formylmethionyl-tRNA, thymidylate, serine, and methionine. In the last 30 years, research on the folate biochemistry of plant species has intensified and been aided by the development of improved methods for folate isolation and characterization. These studies have resulted in basic information on the nature of plant folylpolyglutamates, folate biosynthesis, the enzymology of several folate-dependent reactions, and the roles of chloroplasts, mitochondria, and the cytosol in the pathways of one-carbon metabolism.Key words: plants, folates, folate biosynthesis, folate-dependent enzymes, one-carbon metabolism.

APA, Harvard, Vancouver, ISO, and other styles

3

Shulpekova, Yulia, Vladimir Nechaev, Svetlana Kardasheva, Alla Sedova, Anastasia Kurbatova, Elena Bueverova, Arthur Kopylov, Kristina Malsagova, Jabulani Clement Dlamini, and Vladimir Ivashkin. "The Concept of Folic Acid in Health and Disease." Molecules 26, no. 12 (June 18, 2021): 3731. http://dx.doi.org/10.3390/molecules26123731.

Full text

Abstract:

Folates have a pterine core structure and high metabolic activity due to their ability to accept electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential one-carbon pathways donating methyl-groups to choline phospholipids, creatine, epinephrine, DNA. Compounds similar to folates are ubiquitous and have been found in different animals, plants, and microorganisms. Folates enter the body from the diet and are also synthesized by intestinal bacteria with consequent adsorption from the colon. Three types of folate and antifolate cellular transporters have been found, differing in tissue localization, substrate affinity, type of transferring, and optimal pH for function. Laboratory criteria of folate deficiency are accepted by WHO. Severe folate deficiencies, manifesting in early life, are seen in hereditary folate malabsorption and cerebral folate deficiency. Acquired folate deficiency is quite common and is associated with poor diet and malabsorption, alcohol consumption, obesity, and kidney failure. Given the observational data that folates have a protective effect against neural tube defects, ischemic events, and cancer, food folic acid fortification was introduced in many countries. However, high physiological folate concentrations and folate overload may increase the risk of impaired brain development in embryogenesis and possess a growth advantage for precancerous altered cells.

APA, Harvard, Vancouver, ISO, and other styles

4

Bagley, Pamela J., and Jacob Selhub. "Analysis of Folate Form Distribution by Affinity Followed by Reversed-Phase Chromatography with Electrochemical Detection." Clinical Chemistry 46, no. 3 (March 1, 2000): 404–11. http://dx.doi.org/10.1093/clinchem/46.3.404.

Full text

Abstract:

Abstract Background: Naturally occurring folates exist in multiple forms, differing in pteridine ring structure and number of glutamate residues. The ability to measure these folate coenzymes in tissues and cells gives important information about in vivo folate metabolism. Methods: Folates were heat-extracted from biological samples. A two-column HPLC system with four-channel coulometric electrochemical detection was used for analysis. An affinity column was used first to purify folates from the extract. Purified folates were eluted from the affinity column onto a phenyl analytical column, utilizing a switching valve, and folate forms were separated using an acetonitrile gradient. Results: Folate forms differing in pteridine ring structure and number of glutamate chain residues were identified by retention time and characteristic response across the channels of the detector. Folates were quantified by comparison to an external calibration mixture. Limits of detection for pentaglutamyl folates ranged from 0.21 pmol for tetrahydrofolate to 0.41 pmol for 5-methyltetrahydrofolate. CVs (n = 5) for peaks containing 9–67 pmol of folate were 0.6–6.4% (within day) and 5.2–8.4% (between days). CVs (n = 5) for peaks containing 0.9–3.5 pmol folate were 5.7–16% (within day) and 8.4–13% (between days). Conclusions: This automated HPLC system allows the simultaneous determination of polyglutamyl forms of folates from biological samples, including tetrahydrofolate, 5-methyltetrahydrofolate, formylated folates, and pteroylglutamate. The low detection limits allow analysis of folate form distribution in human samples such as erythrocytes and lymphocytes.

APA, Harvard, Vancouver, ISO, and other styles

5

Chan, Sherwin Y., and Edwin A. Cossins. "The Intracellular Distribution of Folate Derivatives in Pea Leaves." Pteridines 14, no. 1 (February 2003): 17–26. http://dx.doi.org/10.1515/pteridines.2003.14.1.17.

Full text

Abstract:

Abstract After hydrolysis of polyglutamate derivatives, leaf extracts of pea (Pisum sativum L.) seedlings were examined for individual folates using high Performance liquid chromatography and microbiological assays employing Lactobacillus rhamnosus and Pediococcus acidilactici. 14-day seedlings contained 0.17±0.01 nmol folate mg-1 protein that was predominantly methylated and associated with the cytosolic fraction. Percoll gradient-purified mitochondria and chloroplasts contained 11.0±2.3% and 8.4±0.6% of cellular folate, respectively. Mitochondrial folates (0.47±0.11 nmol folate mg-1 protein) were predominately (90%) formylated and unsubstituted. In contrast, chloroplasts contained a less concentrated (0.02±0.001 nmol folate mg-1 protein) folate pool consisting of approximately 30% methylated folate. The total folate content of pea leaves increased by 40% when dark-grown (etiolated) 9-day seedlings were exposed to light for 48 hours. During this light treatment, the mitochondrial folate pool, on a per mg protein basis, increased 10-fold. This light treatment also changed the composition of the mitochondrial folate pool with a shift occurring from methylated to formylated and unsubstituted derivatives. These changes in the folates of greening tissues are discussed in relation to the metabolism of glycine and serine that accompanies photorespiration in leaf tissues.

APA, Harvard, Vancouver, ISO, and other styles

6

WIGERTZ, KARIN, ULLA K. SVENSSON, and MARGARETHA JÄGERSTAD. "Folate and folate-binding protein content in dairy products." Journal of Dairy Research 64, no. 2 (May 1997): 239–52. http://dx.doi.org/10.1017/s002202999700215x.

Full text

Abstract:

Recent findings suggest a protective role for folates in the reduction of neural tube defects and possibly also coronary heart disease and cancer. Consequently, an increase in the daily intake of folates is warranted, which emphasizes the need for quantitative as well as qualitative measurements of dietary folates. Milk plays an important part in the food chain in many Western countries today. Several studies suggest that folate-binding proteins might have an impact on folate absorption and therefore their concentrations are also important. The mean concentration of the predominant form of folate, 5-methyltetrahydrofolate (5-CH3THF), was determined using HPLC in thirteen selected dairy products; skim milk powder, two pasteurized milks, UHT milk, two fermented milks, three whey products and four different cheeses. All results were corrected for recovery by spiking the samples with 5-CH3THF. Effects of storage of dairy products on 5-CH3THF concentrations were also investigated; generally small and insignificant fluctuations were found, except for hard cheese, in which 5-CH3THF decreased significantly. There was a significant seasonal variation in the folate concentration of pasteurized milk which peaked in the summer months. The concentrations of folate-binding protein in skim milk powder and pasteurized milk analysed using an enzyme-linked immunosorbent assay were similar. UHT milk and fermented milk, both of which are processed at temperatures >90°C, contained significantly lower concentrations of folate-binding protein.

APA, Harvard, Vancouver, ISO, and other styles

7

Chan, Sherwin Y., and Edwin A. Cossins. "The Intracellular Distribution of Folate Derivatives in Pea Leaves." Pteridines 14, no. 3 (August 2003): 17–26. http://dx.doi.org/10.1515/pteridines.2003.14.3.17.

Full text

Abstract:

Abstract After hydrolysis of polyglutamate derivatives, leaf extracts of pea (Pisum sativum L.) seedlings were examined for individual folates using high performance liquid chromatography and microbiological assays employing Lactobacillus rhamnosus and Pediococcus acidilactici. 14-day seedlings contained 0.17+0.01 nmol folate mg'1 protein that was predominantly methylated and associated with the cytosolic fraction. Percoli gradient-purified mitochondria and chloroplasls contained 11,0±2.3% and 8.4±0.6% of cellular folate, respectively. Mitochondrial folates (0.47+0.11 nmol folate mg"' protein) were predominately (90%) formylatcd and unsubstituted. In contrast, chloroplasts contained a less concentrated (0.02±0.001 nmol folate mg"' protein) folate pool consisting of approximately 30% methylated folate.The total folate content of pea leaves increased by 40% when dark-grown (etiolated) 9-day seedlings were exposed to light for 48 hours. During this light treatment, the mitochondrial folate pool, on a per mg protein basis, increased 10-fold. This light treatment also changed the composition of the mitochondrial folate pool with a shift occurring from methylated to formylated and unsubstituted derivatives. These changes in the folates of greening tissues are discussed in relation to the metabolism of glycine and serine that accompanies photorespiration in leaf itssues.

APA, Harvard, Vancouver, ISO, and other styles

8

Shohag, M. J. I., Yanyan Wei, Jie Zhang, Ying Feng, Michael Rychlik, Zhenli He, and Xiaoe Yang. "Genetic and physiological regulation of folate in pak choi (Brassica rapa subsp. Chinensis) germplasm." Journal of Experimental Botany 71, no. 16 (July 8, 2020): 4914–29. http://dx.doi.org/10.1093/jxb/eraa218.

Full text

Abstract:

Abstract Folates are one of the essential micronutrients for all living organisms. Due to inadequate dietary intake, folate deficiency remains prevalent in humans. Genetically diverse germplasms can potentially be used as parents in breeding programs and also for understanding the folate regulatory network. Therefore, we investigated the natural genetic diversity of folates and their physiological regulation in pak choi (Brassica rapa subsp. Chinensis) germplasm. The total folate concentration ranged from 52.7 μg 100 gFW–1 to 166.9 μg 100 gFW–1, with 3.2-fold variation. The main folate vitamer was represented by 5-CH3-H4folate, with 4.5-fold variation. The activities of GTP cyclohydrolase I and aminodeoxy chorismate synthase, the first step of folate synthesis, were high in high folate accessions and low in low folate accessions. Analysis of the transcription levels of 11 genes associated with folate metabolism demonstrated that the difference in folate concentrations may be primarily controlled at the post-transcriptional level. A general correlation between total folate and their precursors was observed. Folate diversity and chlorophyll content were tightly regulated through the methyl cycle. The diverse genetic variation in pak choi germplasm indicated the great genetic potential to integrate breeding programs for folate biofortification and unravel the physiological basis of folate homeostasis in planta.

APA, Harvard, Vancouver, ISO, and other styles

9

Khanal, S., J. Xue, R. Khanal, W. Xie, J. Shi, K. P. Pauls, and A. Navabi. "Quantitative Trait Loci Analysis of Folate Content in Dry Beans,Phaseolus vulgarisL." International Journal of Agronomy 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/983641.

Full text

Abstract:

Dry beans (Phaseolus vulgarisL.) contain high levels of folates, yet the level of folate may vary among different genotypes. Folates are essential vitamins and folate deficiencies may lead to a number of health problems. Among the different forms of folates, 5-methyltetrahydrofolate (5MTHF) comprises more than 80% of the total folate in dry beans. The objectives of this paper were to compare selected genotypes of dry beans for the folate content of the dry seeds and to identify quantitative trait loci (QTL) associated with the folate content in a population derived from an inter-gene-pool cross of dry beans. The folate content was examined in three large-seeded (AC Elk, Redhawk, and Taylor) and one medium-seeded (Othello) dry bean genotypes, their six F1(i.e., one-way diallel crosses), and the F2of Othello/Redhawk that were evaluated in the field in 2009. Total folate and 5MTHF contents were measured twice with one-hour time interval. The significant variation (P<0.05) in the folate content was observed among the parental genotypes, their F1progeny, and members of the F2population, ranging from 147 to 345 μg/100 g. There was a reduction in the 5MTHF and total folate contents in the second compared to the first measurement. Dark red kidney variety Redhawk consistently had the highest and pinto Othello had the lowest total folate and 5MTHF contents in both measurements. A single marker QTL analysis identified three QTL for total folate and 5MTHF contents in the first measurement and one marker for the total folate in the second measurement in the F2. These QTL had significant dominance effects and individually accounted for 7.7% to 10.5% of the total phenotypic variance. The total phenotypic variance explained by the four QTL was 18% for 5MTHF and 19% for total folate in the first measurement, but only 8% for total folate in the second measurement.

APA, Harvard, Vancouver, ISO, and other styles

10

Wright, Anthony J. A., Maria J. King, Caroline A. Wolfe, Hilary J. Powers, and Paul M. Finglas. "Comparison of (6S)-5-methyltetrahydrofolic acidv.folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults." British Journal of Nutrition 103, no. 5 (October 26, 2009): 724–29. http://dx.doi.org/10.1017/s0007114509992339.

Full text

Abstract:

Folic acid (pteroylmonoglutamic acid) has historically been used as the reference folate in human intervention studies assessing the relative bioavailability of dietary folate. Recent studies using labelled folates indicated different plasma response kinetics to folic acid than to natural (food) folates, thus obviously precluding its use in single-dose experiments. Since differences in tissue distribution and site of biotransformation were hypothesised, the question is whether folic acid remains suitable as a reference folate for longer-term intervention studies, where the relative bioavailability of natural (food) folate is assessed based on changes in folate status. Healthy adults aged 18–65 years (n163) completed a 16-week placebo-controlled intervention study in which the relative bioavailability of increased folate intake (453 nmol/d) from folate-rich foods was assessed by comparing changes in plasma and erythrocyte folate concentration with changes induced by an equal reference dose of supplemental (6S)-5-methyltetrahydrofolic acid or folic acid. The relative increase in plasma folate concentration in the food group was 31 % when compared with that induced by folic acid, but 39 % when compared with (6S)-5-methyltetrahydrofolic acid. The relative increase in erythrocyte folate concentration in the food group when compared with that induced by folic acid was 43 %, and 40 % when compared with (6S)-5-methyltetrahydrofolic acid. When recent published observations were additionally taken into account it was concluded that, in principle, folic acid should not be used as the reference folate when attempting to estimate relative natural (food) folate bioavailability in longer-term human intervention studies. Using (6S)-5-methyltetrahydrofolic acid as the reference folate would avoid future results' validity being questioned.

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Folate"

1

Chow, Lai-man, and 周勵文. "Folate receptor alpha and reduced folate carrier in endometrialcancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45153188.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Amanna, Karen Ruggio. "Folate status and milk folate concentration in lactating women." Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-11182008-063632/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Tsang, Hiu-may, and 曾嬈媚. "Folate receptor alpha and reduced folate carrier in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4467059X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Scurachio, Regina Spricigo. "Fotodegradação de folatos sensibilizados por flavinas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-17032011-155300/.

Full text

Abstract:

O ácido fólico, a forma mais estável entre os folatos, é indicado como forma de prevenção sendo encontrado em forma de suplementação medicamentosa e alimentos fortificados, como leite e derivados. O folato pode reagir com a riboflavina singlete excitada, 1kq = 4,8·1010 L·mol-1·s-1, como determinado por desativação da fluorescência do estado estacionário, e com a riboflavina triplete excitada, com uma reação um pouco mais lenta, 3kq= 4,8·108 L·mol-1·s-1, como determinado por fotólise de pulso de laser e espectroscopia de absorção de transientes verificando-se que ambos os processos são competitivos e próximos ao limite de difusão. A preferência cinética de um a outro depende da matriz alimentar. O rendimento quântico para solução de riboflavina e de folato preparado em solvente aquoso e deuterado e em meio anaeróbico e aeróbico mostrou a prevalência do mecanismo fotoreacional do Tipo I. A voltametria cíclica apresentou um processo irreversível anódico de dois elétrons para o ácido fólico (E= 1,14 V vs. NHE). Os principais produtos da fotodegradação do folato sensibilizado pela riboflavina foram identificados por LC-IT-MS/MS como: 6-carboxipterina,p-aminobenzoil-L-ácido glutâmico e oxaziridina derivada do ácido fólico, como confirmando a desativação química do estado triplete excitado da riboflavina por transferência de elétrons com subseqüente clivagem oxidativa entre N(10) e C(9) no ácido fólico.
Folic acid, the most stable among folate, is recommended as prevention and it is found in supplementation and fortified foods such as milk and dairy products. The folate can react with singlet-excited state of riboflavin, 1kq= 4.8·1010 L·mol-1·s-1, as determined by steady-state fluorescence quenching, and with triplet-excited state of riboflavin in a slower reaction with 3kq= 4.8·108 L·mol-1·s-1, as determined by laser flash photolysis and transient absorption spectroscopy, verifying that both the processes are competitive and they are near limited diffusion. The kinetic preference depends on the matrix food. The quantum yield for the solution of riboflavin and folate prepared in aqueous and deuterated solvents and in anaerobic and aerobic medium showed the prevalence of the mechanism Type I. The cyclic voltammetry showed an irreversible two-electron anodic process for folate (E = 1.14 V vs. NHE). The main products of folate photodegradation sensitized by riboflavin were identified by LC-IT-MS/MS as: pterin-6-carboxylic acid, p-aminobenzoyl-L-glutamic acid and oxaziridine derivative of folic acid, as confirming chemical quenching of the triplet-excited state of riboflavin by electron transfer with subsequent oxidative cleavage between N(10) and C(9) in folic acid.

APA, Harvard, Vancouver, ISO, and other styles

5

Lawrence, Scott Alan. "The Mechanism of Mitochondrial Folate Transport by the Mitochondrial Folate Transporter." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2066.

Full text

Abstract:

The mitochondrial folate transport protein (MFT) functions to transport folates into the mitochondrial matrix. The MFT is a member of a mitochondrial carrier family (MCF) of proteins that have a high degree of sequence and structural similarities, yet they transport vastly different substrates at high specificities. In this dissertation research, the folate-specific transport mechanism of the MFT was explored using experimental and computational techniques. MFT residues that differed from MCF consensus residues in conserved PxD/ExxK/R motifs and at a predicted substrate-binding site common to all MCF proteins were investigated. Site-directed mutagenesis of these anomalous residues in the MFT revealed that these residues were adapted for optimal folate transport, and that the MCF consensus residues at these positions were incompatible with folate transport. The structure of the MFT was predicted by homology modeling using the solved crystallographic structure of the ADP/ATP carrier as a template and this model was subjected to ~75 ns of molecular dynamics simulations. These simulations predicted a stepwise descent for the folate substrate into the MFT transport cavity and implicated several aromatic and basic residues in folate recognition and orientation. A predicted set of interactions at the base of the transport cavity between the MCF PxD/ExxK/R conserved motif residues did not appear static as previously hypothesized; these interactions appeared to be induced in the presence of the folate substrate. Therefore, we believe it is unlikely that these interactions form a barrier at the base of the transport cavity. We also investigated the role of the MFT in the compartmentalization of folate metabolism. Cell lines were created that could be induced with doxycycline to express either the cytosolic or mitochondrial isoform of the enzyme folylpoly-γ-glutamate synthetase (FPGS). The constructed cell lines were used to study the flux of folylpolyglutamates across the mitochondrial membrane. It appeared that cellular folylpolyglutamates are not transported across the mitochondrial membrane in either direction. We also demonstrated that many antifolates, including methotrexate and pemetrexed, impaired mitochondrial folate uptake. We believe that these folate analogs competitively inhibit the MFT and have purified the MFT protein for future analysis in reconstituted transport systems.

APA, Harvard, Vancouver, ISO, and other styles

6

Scott, D. A. "Folate metabolism in Leishmania." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375461.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Sharp, Linda. "Folate and genetic variation in folate metabolism in the aetiology of colorectal cancer." Thesis, University of Aberdeen, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430975.

Full text

Abstract:

The aim of this thesis was to investigate the roles of folate and polymorphisms in folate metabolising genes in the aetiology of colorectal cancer. The objectives were to: (1) conduct systematic reviews of (a) folate and colorectal neoplasia and (b) polymorphic genes in the folate pathway and colorectal neoplasia; (2) undertake a case-control study of folate, polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and colorectal cancer in the north-east of Scotland; and (2) re-analyse the study data as if it were from a case-only study, comparing the results with those of the case-control analysis. The first systematic review concluded that there was considerable evidence that folate status modulates the risk of developing colon cancer, adenomatous polyps and, possibly, rectal cancer. The risk reduction in the highest compared to the lowest intake group, for colon cancer and adenomas, was in the region of 30-40%. The second systematic review considered polymorphisms in MTHFR, methionine synthase (MTR), methionine synthase reductase (MTRR), cystathionine beta-synthase (CBS) and thymidylate synthase (TS). Homozygosity for the MTHFR 677TT and 1298CC variants was associated with moderately reduced colorectal cancer risk in the majority of studies. There was evidence of gene-environment interaction; in four of five studies, the lowest cancer risk was in 677TT subjects who had higher folate levels (or a “high methyl diet”) while in three studies 677TT homozygotes with the highest alcohol intake had the highest cancer risk. The available evidence on MTHFR C677T and adenomatous polyps was inconclusive. A population-based case-control study of colorectal cancer was undertaken in Grampian health board area. Eligible cases were Grampian residents diagnosed with histologically confirmed primary colorectal cancer during September 1998-February 2000. The primary analysis focused on all colorectal cancer. Disease risk followed an inverted “U” pattern with increasing (total and dietary) folate intake. There was little evidence of relations between disease and intakes of total or dietary vitamin B₁₂, vitamin B₆ or riboflavin or of interactions between these factors and folate. There was a suggestion that protein intake was inversely related to colorectal cancer, which also drove the observation of a modestly increased risk with low, as compared to high, methyl intake (a combination of folate, protein and alcohol intake). A modest, non-significant, reduction in risk was found in those with the 677 TT, compared to the CC, genotype. For A1298C, a slight, non-significant, reduction in risk for homozygotes for the variant allele was found. Significant interactions between the two polymorphisms and total folate intake were observed, although the patterns of interaction were different for each variant and not entirely consistent with published studies.

APA, Harvard, Vancouver, ISO, and other styles

8

Ashfield-Watt, Pauline A. L. "Folate, homocysteine and cardiovascular disease : an investigation of dietary strategies to increase folate status." Thesis, Cardiff University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444123.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Rudd, Michelle. "Folate : friend or foe? : an investigation into the opposing roles of folate in glioma." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/20737/.

Full text

Abstract:

For individuals diagnosed with a glioma, survival rates have shown little improvement over the last 40 years due to the heterogeneity of tumours and the difficulty of specifically targeting the tumour whilst sparing surrounding healthy tissue. Altered gene methylation is often seen in glioma cells, but methylating agents such as folate, may reverse aberrant methylation. Folate treatment has shown a beneficial effect, reducing risk of certain cancers (colorectal, breast, squamous cell carcinoma) but other studies have shown detrimental results whereby proliferation of cancer increased (mammary, prostate). The aim of this thesis was to investigate the opposing roles of folate in glioma. The glioma cell lines 1321N1, U87 MG and non-cancerous glial SVGp12 cells were used for analysis. Cells were grown in folate deficient, folic or folinic acid supplemented media and compared to standard cell culture media. Cell viability, cell cycle and apoptosis analysis along with methylation status and protein expression of the genes of interest; PTEN, FOLR1, RFC, PCFT, and MTHFR were analysed to determine differences between cell lines following treatment. The investigation showed that folic and folinic acid behaved differently depending on concentration used and the cell lines treated. Folic acid at 5 µg/ml significantly increased cell viability and protein expression levels in the U87 MG and SVGp12 cell lines, whilst the folinic acid (35 µg/ml) resulted in significant decreased cell viability, increased apoptotic activity and down regulation of the folate transporters in the 1321N1, U87 MG and SVGp12 cell lines. Folate treatment did not significantly alter cell cycle phase. Altered methylation of genes specific for folate metabolism and transport did not explain the cytotoxic effects of folate in cell lines. In conclusion, the work presented here signifies that folinic acid rather than folic acid would be more suitable for glioma treatment. The effect of folinic acid treatment on glioma had not been previously studied, and the knowledge obtained here regarding the effects of folic and folinic acid treatment on folate transporter expression in glioma has advanced understanding.

APA, Harvard, Vancouver, ISO, and other styles

10

Díaz, de la Garza Rocío Isabel. "Folate engineering in tomato fruit." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0017287.

Full text

APA, Harvard, Vancouver, ISO, and other styles

More sources

Books on the topic "Folate"

1

Massaro, Edward J., and John M. Rogers. Folate and Human Development. New Jersey: Humana Press, 2002. http://dx.doi.org/10.1385/1592591647.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Preedy, Victor R., ed. B Vitamins and Folate. Cambridge: Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/9781849734714.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

J, Massaro Edward, and Rogers John M, eds. Folate and human development. Totowa, N.J: Humana Press, 2002.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

4

name, No. Folate and human development. Totowa, NJ: Humana Press, 2002.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

5

Bailey, Lynn B. Folate in health and disease. 2nd ed. Boca Raton: Taylor & Francis, 2010.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

6

1948-, Bailey Lynn B., ed. Folate in health and disease. New York: M. Dekker, 1995.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

7

McVitty, Rosalind Shirley. In vitro studies of folate catabolism. [S.l: The Author], 1997.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

8

Surdhar, Mohinderjeet Singh. Folate metabolism in the female weanling rat. Birmingham: Aston University. Department of Molecular Sciences, 1987.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

9

Kurtzweil, Paula. How folate can help prevent birth defects. [Rockville, MD: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, 1996.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

10

Kurtzweil, Paula. How folate can help prevent birth defects. [Rockville, MD: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, 1997.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

More sources

Book chapters on the topic "Folate"

1

Verster, Joris C., Thomas M. Tzschentke, Kieran O’Malley, Francis C. Colpaert, Bart Ellenbroek, Bart Ellenbroek, R. Hamish McAllister-Williams, et al. "Folate." In Encyclopedia of Psychopharmacology, 544. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_475.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Ulrich, Cornelia M., Xinran Xu, Amy Liu, and Jia Chen. "Folate." In Bioactive Compounds and Cancer, 387–410. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-627-6_18.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Ball, G. F. M. "Folate." In Bioavailability and Analysis of Vitamins in Foods, 439–96. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-3414-7_13.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Bailey, Lynn B., and Marie A. Caudill. "Folate." In Present Knowledge in Nutrition, 321–42. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781119946045.ch21.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Ravanel, Stéphane, and Fabrice Rébeillé. "Folate." In Phytonutrients, 173–202. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118253649.ch6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Hyde, John E., and Ingrid B. Müller. "Folate Metabolism." In Encyclopedia of Malaria, 1–11. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8757-9_1-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Narisawa, K. "Folate Disorders." In Inborn Metabolic Diseases, 599–606. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-02613-7_46.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Ko, Alex. "Folate Antagonists." In Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures, 125–43. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9704-0_7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Desnick, Robert J., Orlando Guntinas-Lichius, George W. Padberg, Gustav Schonfeld, Xiaobo Lin, Maurizio Averna, Pin Yue, et al. "Folate Deficiency." In Encyclopedia of Molecular Mechanisms of Disease, 666–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_648.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Kane, Madeleine A., and Samuel Waxman. "Role of Folate Binding Proteins in Folate Metabolism." In Pathology Reviews • 1990, 39–48. Totowa, NJ: Humana Press, 1990. http://dx.doi.org/10.1007/978-1-4612-0485-5_4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Folate"

1

Hou, Zhanjun, Steve Orr, Erika Etnyre, Christina Cherian, and Larry Matherly. "Abstract 873: Acute regulation of human reduced folate carrier by folates as a novel adaptive mechanism to folate deprivation." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-873.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Parker, Nikki, Christina Cherian, Larry Matherly, and Christopher P. Leamon. "Abstract 4591: The folate receptor-targeted agents, vintafolide and etarfolatide, are not substrates for the reduced folate carrier or the proton-coupled folate transporter." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4591.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Rybinski, Katherine A., Brian E. Tomkowicz, Barton A. Kamen, Luigi Grasso, Nicholas Nicolaides, Philip Sass, and Yuhong Zhou. "Abstract 2591: Folate receptor alpha: A promoter of cancer cell proliferation that is independent of folate." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2591.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Bandara, Nimalka A., and Philip S. Low. "Abstract 2593: Multitargeted receptor tyrosine kinase inhibitors synergize with folate-hapten mediated immunotherapy in folate receptor positive cancers." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2593.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Chandrupatla, DMSH, CJ van der Laken, R. Vos, M. Verlaan, R. van Kooij, AD Windhorst, Q. Chen, et al. "FRI0041 In vivo monitoring of anti-folate therapy in arthritic rats using [18f]fluoro-peg-folate and pet." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.4803.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Nunez, Maria Ines, Milind Suraokar, Carmen Behrens, Denise M. Woods, Heather Lin, Jack Lee, Reza J. Mehran, Wilbur Franklin, Anne Tsao, and Ignacio Ivan Wistuba. "Abstract 4121: Folate pathway in malignant pleural mesothelioma (MPM): Novel therapeutic opportunities due to folate receptor alpha overexpression." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4121.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Covello, Kelly L., Amy Wiebesiek, Leila Alland, Yijin She, Qiuyan Wu, and Francis Lee. "Abstract 5532: Folate receptor expression in human malignancies to select patients who would benefit from folate conjugated therapy." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5532.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Leamon, CP, JA Reddy, M. Nelson, A. Bloomfield, R. Dorton, and M. Vetzel. "Abstract P2-16-24: Folate targeted SMDC’s: A possible new treatment alternative for folate receptor expressing TNBC patients." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p2-16-24.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Barick, K. C., Suman Rana, and P. A. Hassan. "Folate-conjugated luminescent Fe3O4 nanoparticles for magnetic hyperthermia." In SOLID STATE PHYSICS: Proceedings of the 58th DAE Solid State Physics Symposium 2013. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4872674.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Ducker, Gregory S., Li Chen, Xin Teng, and Joshua D. Rabinowitz. "Abstract 4709: Compartmental flexibility in mammalian folate metabolism." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4709.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Folate"

1

McMartin, Kenneth E. Control of Alcoholism-Related Folate Deficiency by Regulation of Urinary Folate Excretion. Fort Belvoir, VA: Defense Technical Information Center, October 2001. http://dx.doi.org/10.21236/ada398167.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Lobo, Rebecca. Epigenetic Mechanisms of Folate Nutrition in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, April 2012. http://dx.doi.org/10.21236/ada563075.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Lobo, Rebecca. Epigenetic Mechanisms of Folate Nutrition in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, April 2011. http://dx.doi.org/10.21236/ada553202.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Chen, Jia. Folate Intake, Genetic Susceptibility and Risk of Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2001. http://dx.doi.org/10.21236/ada398935.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Branda, Richard F. Effect of Folate on the Efficacy and Toxicity of Cancer Chemotherapy. Fort Belvoir, VA: Defense Technical Information Center, September 2000. http://dx.doi.org/10.21236/ada393306.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Calero, Monica, and Ruth N. Collins. Direct Effects of Folate Metabolism on Gene Expression in Metastatic Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada408721.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Calero, Monica, and Ruth N. Collins. Direct Effects of Folate Metabolism on Gene Expression in Metastatic Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2003. http://dx.doi.org/10.21236/ada419141.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

McFadden, Ian. Folate-Targeted Proteolytic Macromolecules for Targeted Drug Delivery and Optical Tumor Imaging. Fort Belvoir, VA: Defense Technical Information Center, February 2011. http://dx.doi.org/10.21236/ada552633.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Shrubsole, Martha J., and Wei Zheng. Folate and Breast Cancer: Role of Intake, Blood Levels and Metabolic Gene Polymorphisms. Fort Belvoir, VA: Defense Technical Information Center, June 2003. http://dx.doi.org/10.21236/ada418353.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Davies, Julian A. Contrast Agents for Breast Cancer Diagnosis by Magnetic Resonance Imaging: Targeting the Folate Receptor. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada408779.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!