Dissertations / Theses on the topic 'Flux Map'
To see the other types of publications on this topic, follow the link: Flux Map.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 37 dissertations / theses for your research on the topic 'Flux Map.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Gunow, Geoffrey Alexander. "LWR fuel reactivity depletion verification using 2D full core MOC and flux map data." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/97963.
Full textAbstract:
Thesis: S.M., Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, 2015.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 89-90).
Experimental quantification of PWR fuel reactivity burnup decrement biases and uncertainties using in-core flux map data from operating power reactors has previously been conducted employing analytical methods to systematically determine experimental fuel reactivities that best match measured fission rate distributions. This optimal core reactivity distribution that best matches the measured fission rate distribution is assumed to be associated with the true fuel reactivity distribution. Some parties have questioned whether fortuitous cancellation of errors between various approximations inherent in the 3D nodal diffusion core analysis models might have caused reactivity decrement biases and uncertainties to be unrealistically small. In this study, the BEAVRS benchmark is modeled with both 2D, full-core, multi-group transport calculations and 2D and 3D nodal diffusion calculations. The calculated reaction rates are compared with measured in-core detector reaction rates supplied in the benchmark. These models are used in conjunction with analytical methods to obtain fuel reactivity biases and uncertainties. Results demonstrate that fuel batch reactivities inferred from flux map data using full-core transport calculations are nearly identical to those inferred using nodal diffusion calculations. Consequently, nodal methods do not contribute significantly to reactivity decrement biases. Fuel reactivity biases and uncertainties inferred from 3D nodal diffusion calculations remain valid.
by Geoffrey Alexander Gunow.
S.M.
2
Abbasi, Faezeh [Verfasser], Bruno [Akademischer Betreuer] Thomauske, Rahim [Akademischer Betreuer] Nabbi, and Oliver [Akademischer Betreuer] Pooth. "Monte Carlo based modeling and simulation of neutron flux distribution and activity map of the German research reactor FRJ-2 / Faezeh Abbasi ; Bruno Thomauske, Rahim Nabbi, Oliver Pooth." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1125911379/34.
Full text
3
Caro, Gregory P. "Direct numerical simulations of diffusive staircases in the Arctic." Thesis, Monterey, Calif. : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/theses/2009/Mar/09Mar%5FCaro.pdf.
Full textAbstract:
Thesis (M.S. in Physical Oceanography)--Naval Postgraduate School, March 2009.Thesis Advisor(s): Radko, Timour. "March 2009." Description based on title screen as viewed on April 23, 2009. Author(s) subject terms: Double-diffusion, diffusive convection, heat flux, thermohaline staircase, Includes bibliographical references (p. 39-41). Also available in print.
4
Jacobi, Christoph, and Daniel Mewes. "Heat flux classification of CMIP5 model results using self-organizing maps." Universität Leipzig, 2019. https://ul.qucosa.de/id/qucosa%3A74181.
Full textAbstract:
We used the self-organizing maps (SOMs) method on eight models that
participated in the Coupled model intercomparison project phase 5 (CMIP5) and two
different greenhouse gases (GHG) concentration experiments. The SOMs were created from the winter 500 hPa horizontal temperature flux for each model. The clustering by the SOM revealed that in addition to the three flux pathways found in reanalyses (Pacific, Atlantic and Siberian/continental pathway), superpositions of these occur for the free running climate models, which develop their dynamic more freely than the reanalyses.
It was found that the general structure of fluxes is indirectly dependent on the GHG
concentrations, as the derived results from SOM patterns are different between the two GHG concentrations. It is suggested that flux patterns change from stable cyclonic motion over the north pole to flux pathways that feature more meridional fluxes through the North Atlantic and North Pacific into the Arctic.Die Methode der Self-Organizing Maps (SOMs) wurde auf acht CMIP5-Modelle mit jeweils zwei verschiedenen Treibhausgasszenarien angwendet. Die SOMs wurden für jedes Modell und jede der beiden Modelläufe für den horizontalen Temperaturfluss in 500 hPa im Winter erstellt. Zusätzlich zu den aus der Analyse von Reanalyse-Daten erwarteten drei Transportwegen (pazifisch, atlantisch und sibirisch/kontinental) wurden Überlagerungen dieser gefunden. Es konnte gezeigt werden, dass die grundsätzliche Struktur der Transporte indirekt abhängig von der Treibhausgaskonzentration ist. Die Ergebnisse deuten darauf hin, dass sich die generelle Struktur des atmosphärischen Transports von einer stabilen zyklonalen Bewegung über dem Nordpol sich zu Transporten verschiebt, welche meridionale Transporte über den Nortdatlantik und den Nordpazifik in die Arktis führen.
5
Wright, Mark T. "Flame spread on composite materials for use in high speed craft." Link to electronic version, 1999. http://www.wpi.edu/Pubs/ETD/Available/etd-110599-160802/.
Full text
6
Žoldoš, Petr. "Aplikace pro zobrazení modelu bezdrátové sítě." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2011. http://www.nusl.cz/ntk/nusl-218923.
Full textAbstract:
The first step of Master's thesis was to gain knowledge about technologies Adobe Flex SDK and Google Maps API. Knowledge was used to develop an application, which let users create, generate and modify graphical wireless network model. Position and characteristics of each single unit are monitored either in a map interface or in building plans. Dates are gathered from forms filled by current user, from external file or periodically from connected database system. Theoretical part enlightens technologies that were used. It describes program development and solutions, which were made, along with examples of the source code. Included are printscreens of graphical user interface as well as description of how does it all work.
7
Preston, Brianne Alysse. "Medicine in flux : an examination of Lázaro de Soto's exegesis of 'Places in Man'." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2944.
Full textAbstract:
This thesis examines Lázaro de Soto's commentary on the Hippocratic text, Places in Man, which is included in his 1594 volume, Tomus primus commentationum in Hippocratis libros. Castilian medicine in the Renaissance has been the subject of only limited study in Anglophone literature. Moreover, de Soto himself has received even less attention and thus a contextualisation of this author and his commentary provides a unique opportunity to broaden our understanding of how ancient medicine was utilised by Renaissance physicians. A case study approach is employed to examine what can be learned about the author of the commentary himself, in addition to asking how this information can be extrapolated further to gain a greater understanding of early modern medicine. This thesis uses both de Soto's work and his biography to address these questions. Many issues that have informed de Soto's medical understanding are considered, including his education and career, and wider medical movements, such as Vesalianism and humanism. Additionally, specific areas of medicine are given special consideration, including anatomy, physiology, pathology and nosology, precepts and de Soto's reception of the Hippocratic author's ideology. In these explorations of de Soto's comments certain trends begin to emerge. The first, which de Soto states explicitly in his dedication, is a concern for the utilitas publica, as the author tries to provide useful medical information and clarification of the Hippocratic text for practical purposes. Moreover, de Soto uses his commentary as a means to demonstrate his humanist erudition, copiously citing ancient authors, both medical and literary. Finally, throughout de Soto's comments he champions the contested Galenism, rejecting newer theories and connecting Galenism to Places in Man in order to strengthen Galenic authority. In short, de Soto employs this commentary to further both his career and his Galenic understanding of medicine.
8
Ma, Zhegang. "Development of MURR flux trap model for simulation and prediction of sample loading reactivity worth and isotope production." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://edt.missouri.edu/Winter2007/Dissertation/MaZ-050807-D7038/.
Full textAbstract:
Thesis (Ph. D.)--University of Missouri-Columbia, 2007.The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on September 27, 2007) Vita. Includes bibliographical references.
9
Gandra, Beatriz Fausta. "Desenvolvimento de modelo matemático do fluxo de líquidos no cadinho do alto-forno." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/MAPO-7R5MM3.
Full textAbstract:
Molten iron and slag flow play a critical role in the blast furnace lower zone, transporting mass and energy, whilst impairing and redistributing gas flow. In turn, molten iron and slag undergo physical and chemical changes, and are redistributed radially while it is descent to the hearth. At the blast furnace operation is common fluctuation, accompanying the cycles of iron and slag leak. The liquids accumulation into the hearth and its influence on the descent of the load is the main cause of thatfluctuation. It is possible to observe that there is an increase in the blow pressure during the period among twice leaks, and the pressure decrease only along the tapping. Using the conservation flux and energy equation, the liquids flow inside the blast furnace can be characterised. It is strongly influenced by the radial variation in void fraction entering the furnace, gas flow in the vicinity of the raceway and the furnace profile. The slag flow is more sensitive to operating conditions than molten iron. In this paper, it was made an discussion about the liquid movement inside the hearth of Usiminas Blast-Funace 3. This study included a mathematical model development using a balance of forces that allows to evaluate the dead man's flotation, based on the characteristics of the blast furnace and in its operational conditions. Also, with new calculation routines, that result is used then to feed the mathematical model of liquids flow, previously developed. The results indicate that the drainage behaviour and residual iron and slag volume are affected by the conditions inside the hearth; the determination of the dead manfluctuation is linked to the variation of the blow and top pressure. In addition, the weight of the burden in the blast furnace have a great influence too; the movement of the liquid inside a hearth is very influenced by the situation of the dead man's flotation; the homogeneous variation of the coke granulometry has no strongly influence in thedistribution of the liquids, ether in the residence time. However, the particle size distribution of the coke along the radio inside the hearth has strong influence in the liquid flow lines, and consequently, in its retention.O escoamento de gusa e escória no interior do cadinho tem importante função na zona inferior do alto-forno. Esse fenômeno envolve o transporte de massa e energia, e afeta a distribuição do fluxo gasoso. Em geral, esses líquidos sofrem transformações físicas e químicas, e são redistribuídos radialmente, durante a passagem pelo homem morto na descida para o cadinho. Na operação do alto-forno são comuns flutuações em seu comportamento, acompanhando os ciclos de vazamento de gusa e escória. O acúmulo de líquidos no cadinho e sua influência sobre a descida da carga é a principal causa dessas flutuações. A manutenção da adequada permeabilidade na região do homem morto é crucial para melhor drenagem de gusa e escória, e, conseqüentemente, melhor estabilidade e eficiência da operação do forno. Quando a permeabilidade piora, inevitavelmente, ocorre aumento na interação entre líquidos e gases, causando acúmulo de líquidos entre as partículas de coque, e, desse modo, limitando a capacidade de sopro e a produtividade do forno. O fluxo de líquidos no alto-forno pode ser caracterizado usando-se equações gerais de conservação de massa e energia. Sabe-se que ele é fortemente influenciado pela fração de vazios no interior do forno, pelo fluxo de gás nas vizinhanças do raceway e pelo perfil do alto-forno. O fluxo de escória altera mais as condições operacionais quando comparado ao de gusa. Assim, neste estudo, é feita uma abordagem sobre o escoamento dos líquidos no cadinho, tratando assuntos relativos ao esgotamento dos fornos. É também apresentada a adequação de um modelo matemático de fluxo de líquidos no interior do cadinho, desenvolvido previamente, com o objetivo de se avaliar o comportamento do escoamento de líquidos no interior do forno, em função de alterações nas condições operacionais.
10
Mba, Mintsa Léa. "Synthèse et évaluation angiogénique d'analogues du M6P." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCM0028.
Full textAbstract:
L’angiogenèse, est le garant de l’intégrité vasculaire, grâce à la formation de nouveaux vaisseaux sanguins à partir des préexistants. Cette néovascularisation est régulée par des facteurs angiogéniques. Plusieurs stimuli participent au déséquilibre de la balance angiogénique, une vascularisation anormale en résulte. L’intérêt des thérapies actuelles est de restaurer une vascularisation normale, par ciblage des facteurs impliqués dans le processus angiogénique. Il fut démontré que le RM6P-CI est partie prenante dans ce mécanisme. Il a la particularité d’interagir avec plusieurs ligands, dont le M6P et ses dérivées.Il est question de savoir si le M6A, un dérivé isostère du M6P, se lie au RM6P-CI. Pour cela, le test CAM légèrement modifié, a été réapproprié pour confirmer premièrement l’activité pro-angiogénique du M6A. Deuxièmement la technique de cytométrie en flux est utilisée pour mettre en évidence l’interaction entre le M6A et le RM6P-CIAngiogenesis is the protector of vascular integrity, through the formation of new blood vessels from pre-existing vessels. The angiogenesis is regulated by the angiogenic factors. Several stimuli are involved in the angiogenic balance’s destabilization, which produces an unusual vascularization. The interest of conventional and targeted therapies is to restore a normal vascularization, by targeting all the factors which are involved in the angiogenic process. It has been demonstrated that the CI-M6PR is involved in this mechanism. This receptor has the distinction of having more binding sites, so a variety of ligands, including the M6P and its analogs. During this study we want to know if the M6P, isostere analog of M6P, interacts with the CI-M6PR. For this, we reappropriated the assay CAM, slightly modified, to confirm at first the pro-angiogenic activity of M6A. In a second step we will use the flow cytometry technique to highlight the interaction between the M6A and CI- M6PR
11
Masakapalli, Shyam Kumar. "Network flux analysis of central metabolism in plants." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:ac8b3836-9ab7-4060-b50a-df8aaa0e4ba5.
Full textAbstract:
The aim of this thesis was to develop stable-isotope steady-state metabolic flux analysis (MFA) based on 13C labeling to quantify intracellular fluxes of central carbon metabolism in plants. The experiments focus on the analysis of a heterotrophic cell suspension culture of Arabidopsis thaliana (L) Heynh. (ecotype Landsberg erecta). The first objective was to develop a robust methodology based on combining high quality steady-state stable labeling data, metabolic modeling and computational analysis. A comprehensive analysis of the factors that influence the outcome of MFA was undertaken and best practice established. This allowed a critical analysis of the subcellular compartmentation of carbohydrate oxidation in the cell culture. The second objective was to apply the methodology to nutritional perturbations of the cell suspension. A comparison of growth on different nitrogen sources revealed that transfer to an ammonium-free medium: (i) increased flux through the oxidative pentose phosphate pathway (oxPPP) by 10% relative to glucose utilisation; (ii) caused a substantial decrease in entry of carbon into the tricarboxylic acid cycle (TCA); and (iii) increased the carbon conversion efficiency from 55% to 69%. Although growth on nitrate alone might be expected to increase the demand for reductant, the cells responded by decreasing the assimilation of inorganic N. Cells were also grown in media containing different levels of inorganic phosphate (Pi). Comparison of the flux maps showed that decreasing Pi availability: (i) decreased flux through the oxPPP; (ii) increased the proportion of substrate fully oxidised by the TCA cycle; and (iii) decreased carbon conversion efficiency. These changes are consistent with redirection of metabolism away from biosynthesis towards cell maintenance as Pi is depleted. Although published genome-wide transcriptomic and metabolomic studies suggest that Pi starvation leads to the restructuring of carbon and nitrogen metabolism, the current analysis suggests that the impact on metabolic organisation is much less extreme.
12
Araujo, Alexandre Vicentini de. "Aplicação dos princípios da construção enxuta em canteiros de obras suportada por simulação computacional." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/8553.
Full textAbstract:
Submitted by Alison Vanceto (alison-vanceto@hotmail.com) on 2017-02-17T12:11:12Z
No. of bitstreams: 1
DissAVA.pdf: 5462126 bytes, checksum: dd39f79a2b4214655f4466707c8f0fab (MD5)Approved for entry into archive by Ronildo Prado (ronisp@ufscar.br) on 2017-03-09T19:27:15Z (GMT) No. of bitstreams: 1 DissAVA.pdf: 5462126 bytes, checksum: dd39f79a2b4214655f4466707c8f0fab (MD5)
Approved for entry into archive by Ronildo Prado (ronisp@ufscar.br) on 2017-03-09T19:27:26Z (GMT) No. of bitstreams: 1 DissAVA.pdf: 5462126 bytes, checksum: dd39f79a2b4214655f4466707c8f0fab (MD5)
Made available in DSpace on 2017-03-09T19:39:36Z (GMT). No. of bitstreams: 1 DissAVA.pdf: 5462126 bytes, checksum: dd39f79a2b4214655f4466707c8f0fab (MD5) Previous issue date: 2016-08-30
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
This research aims to propose and simulate various scenarios based on the principles of Lean Construction aiming to run a reticulated structure of reinforced concrete residential building with multiple floors within the stipulated time in its planning, taking as within seven days (takt time) to completion. The research strategies adopted included a literature review, identification of application opportunities of the principles of Lean Construction, the development of computational model that represented the studied structure, as well as the various scenarios and their simulation. The opportunities of application of the Lean Construction principles were identified through evaluation of Value Stream Mapping (VSM) and Line of Balance (LB). Five scenarios were prepared, the first being the reference, from which were simulated improvements with the use of simulation software ProModel® in 2014. Each version simulation carried out with consideration of an improvement based on the principles of Lean Construction, resulted in the reduction of lead time, converging in the simulation of the latter scenario, for a little higher than the takt time. As a partial indicator of simulation scenarios were evaluated the average cycle times, drive, hold and conversion data they extracted the software used. A comparison of time between the first scenario, depicted as representing the simple observation of the site plus the inherent variability and the latter scenario, characterized by cumulative application of the principles of lean construction, showed that the cycle time returned a reduction in the order of 29% handling increased by 105%, the expected reduced by 54% and the conversion time reduced by 26%. The main result achieved in the fifth scenario was a Lead Time 66.2 hours production. It can be seen that the use of the VSM and simulation provides a clear and concise communication on lean approaches and thus allows the understanding and continuing evolution of Lean concepts.
Este trabalho tem por objetivo propor e simular vários cenários com base nos princípios da Construção Enxuta objetivando executar uma estrutura reticulada de concreto armado de uma edificação residencial de múltiplos pavimentos dentro do prazo estipulado no seu planejamento, tendo-se como prazo de sete dias (takt time) para sua finalização. As estratégias de pesquisa adotadas incluíram a revisão bibliográfica, a identificação das oportunidades de aplicação dos princípios da Construção Enxuta, a elaboração do modelo computacional que representou a estrutura estudada, assim como os vários cenários e sua simulação. As oportunidades da aplicação dos princípios da Construção Enxuta foram identificadas por meio da avaliação do Mapeamento do Fluxo de Valor (MFV) e Linha de Balanço (LB). Foram elaborados 5 cenários, sendo o primeiro o de referência, a partir do qual foram simuladas as melhorias com uso do software de simulação ProModel® na versão 2014. Cada simulação realizada, com a consideração de uma melhoria com base nos princípios da Construção Enxuta, resultou na redução do lead time, convergindo, na simulação do último cenário, para um valor pouco superior ao takt time. Como indicador parcial dos cenários da simulação, foram avaliados o valor médio dos tempos de ciclo, movimentação, espera e conversão, dados estes extraídos do software utilizado. A comparação dos tempos entre o primeiro cenário, caracterizado como a representação da simples observação do canteiro acrescido sua variabilidade inerente, e o último cenário, caracterizado pela aplicação cumulativa dos princípios da construção enxuta, mostrou que o tempo de ciclo retornou uma redução na ordem de 29%, a movimentação aumentou em 105%, a espera reduziu em 54% e o tempo de conversão reduziu em 26%. O principal resultado alcançado no quinto cenário, foi um Lead Time de produção de 66,2 horas. Pode-se observar que o uso do MFV e da simulação fornece uma comunicação clara e concisa sobre abordagens enxutas e, desta forma, permite a compreensão e a evolução contínua dos conceitos Lean.
13
Borba, Filho Luiz Gonzaga Miranda. "Adimensionalização e proposta de novas modelagens de transições para o mapa de fluxo de Taitel." [s.n.], 1990. http://repositorio.unicamp.br/jspui/handle/REPOSIP/265684.
Full textAbstract:
Orientador: Antonio Carlos BannwartDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica
Made available in DSpace on 2018-07-13T22:03:45Z (GMT). No. of bitstreams: 1 BorbaFilho_LuizGonzagaMiranda_M.pdf: 2870239 bytes, checksum: f62046ca346f34f39e21918dbb89efcd (MD5) Previous issue date: 1990
Resumo: O esforço nas últimas décadas de compreender o fenômeno do escoamento bifásico gás-líquido em tubos tem levado à conclusão de que o conhecimento prévio do padrão de fluxo, o que é obtido a partir de um mapa de fluxo apropriado, é de fundamental importância. Neste trabalho, é apresentada uma adimensionalização e extensão do mapa de fluxo de Taitel et alii (1980), usando os números adimensionais de Duns & Ros (1963). Esta adimensionalização, além de permitir a comparação entre os resultados obtidos por Taitel et ali i (1980) e Duns & Ros (1963), ainda confere ao mapa de fluxo de Taitel et alii (1980) um caráter de maior generalidade. São também apresentados resultados experimentais permitindo a verificação das principais modelagens de transições encontradas na literatura. Os experimentos foram realizados com misturas ar-água em diversas proporções, escoando no interior de uma tubulação vertical com diâmetro de 5,1cm e seção de teste de comprimento 7,16m. Válvulas de fechamento rápido foram utilizadas para as medições das frações de vazios. É sugerida a adoção das fronteiras entre os padrões de fluxo em bolhas e em bolhas dispersas, e entre bolhas dispersas e golfadas, Mishima & Ishii (1984) para a transição entre os propostas por Taitel et alii (1980). Entretanto, a fluxo em golfadas e agitante é preferida à de correção na transição sugerida por Taitel et alii (1980) entre o fluxo em bolhas e em golfadas é incorporada para levar em conta o efeito "enxame" de bolhas sobre a velocidade de como proposta de padrões de Taitel. Uma escorregamento entre as fases. Uma nova modelagem de transição entre os padrões intermitente e anular, é sugerida o que torna esta fronteira mais compatível com os dados experimentais disponíveis
Abstract: The effort in the last decades to understand the phenomenon of two phase gas-liquid flow in pipes has lead to the conclusion that the precise identification of flow patterns, obtained from an appropriate flow pattern map is of fundamental importance. In this work a dimensionless form and extension of the map proposed by Taitel et aI. (1980) is presented using the dimensionless numbers suggested by Duns & Ros (1963). This new dimensionless map allows comparisons between results obtained by Taitel et al.(1980) and Duns & Ros (1963) besides confering a character of generality to Taitel et aI. flow map. Experimental results are also presented to verify flow pattern transitions found in the literature. Experiments were conducted using variable proportions of air-water mixtures in a vertical tubing of 5.1cm diameter and 7.16 meter long testing section. Quick closing valves were used for measuring liquid holdup. For the transition between bubble and dispersed bubble flow and between dispersed bubble and slug flow, it is suggested that the solutions presented by Taytel et aI. (1980) be adopted. However, for the transition between slug and churn flow the frontier proposed by Mishima & Ishii (1984) phases. A new transition between intermittent flow and mist flow is proposed which makes this frontier more compatible with is prefered. To the bubble-slug flow transition presented by Taitel et aI. a correction is added to take into account the effect of bubble concentration upon the slipage between the the available experimental data
Mestrado
Mestre em Engenharia de Petróleo
14
Esteves, Rita Sofia Santos. "Lean Banking : estudo de caso na empresa BNP Paribas." Master's thesis, Instituto Superior de Economia e Gestão, 2019. http://hdl.handle.net/10400.5/19983.
Full textAbstract:
Mestrado em Gestão e Estratégia IndustrialDevido à crise existente no setor bancário verificado nos últimos anos, as instituições bancários tiveram de recorrer a novos sistemas de gestão e controlo das operações de maneira a reduzir desperdícios e conseguir manter a sua oferta de serviços com uma elevada qualidade, assumindo vantagem competitiva. Os conceitos lean services e lean banking são assim utlizados neste setor de serviços como resposta à situação atual do mercado bancário com o intuito de desenvolver um ambiente mais produtivo, que através do envolvimento de todos torna possível otimizar processos, reduzir desperdícios e aumentar a qualidade do produto final. Consequentemente, possibilita-se a redução de custos e o aumento da satisfação e confiança dos clientes. Tem como objetivo estudar os conceitos lean services aplicados a uma instituição bancária e expor as adaptações realizadas aos seus conceitos para a sua utilização como lean banking. Ao longo do presente trabalho foi realizada uma revisão sobre o estado de conhecimento da filosofia lean production e lean banking, designadamente os seus princípios, conceitos e ferramentas, desde a sua adoção na indústria automóvel até à atualidade. Foi posteriormente realizado um caso de estudo num departamento específico do BNP Paribas Portugal, onde foram implementados os conceitos lean, analisados os resultados obtidos e feita a proposta de melhoria com base nos mesmos, retirando conclusões sobre as vantagens da sua utilização.
Due to the crisis in the banking sector in recent years, banking institutions have had to resort to new systems of management and control of operations in order to reduce waste and manage to maintain their offer of services with a high quality, assuming a competitive advantage. The lean services and lean banking concepts are thus used in this service sector as a response to the current situation of the banking market in order to develop a more productive environment, which, through the involvement of all, makes it possible to optimize processes, reduce waste and increase the quality of the final product. As a result, costs can be reduced and customer satisfaction and confidence increased. Its objective is to study the lean services concepts applied to a banking institution and expose the adaptations made to its concepts for their use as lean banking. Throughout this work, a review was carried out on the state of knowledge of lean production and lean banking philosophy, namely its principles, concepts and tools, from its adoption in the automotive industry to the present day. A case study was subsequently carried out in a specific department of BNP Paribas Portugal, where the lean concepts were implemented, the results obtained were analyzed and a proposal for improvement was made based on them, drawing conclusions about the advantages of their use.
info:eu-repo/semantics/publishedVersion
15
Montelo, Marcos Silva. "Solução de problemas de fluxo de potencia mal condicionados através do método GMRES incluindo controladores FACTS." Universidade Federal do Maranhão, 2016. http://tedebc.ufma.br:8080/jspui/handle/tede/1701.
Full textAbstract:
Submitted by Rosivalda Pereira (mrs.pereira@ufma.br) on 2017-06-26T19:40:40Z
No. of bitstreams: 1
MarcosSilvaMontelo.pdf: 2980665 bytes, checksum: 3b07ab02be8c6a4e17cda1a61787ffe2 (MD5)Made available in DSpace on 2017-06-26T19:40:40Z (GMT). No. of bitstreams: 1 MarcosSilvaMontelo.pdf: 2980665 bytes, checksum: 3b07ab02be8c6a4e17cda1a61787ffe2 (MD5) Previous issue date: 2016-02-26
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
In this work is investigated the performance of the GMRES Method in studies of power flow extremely loaded, ill-conditioned and including FACTS Controllers, focusing on Jacobian matrix with high numbers of conditioning and real eigenvalue close to zero, in order to consolidate the virtues of GMRES in ill-conditioned problems. From this information you can set operating scenarios that may indicate points of robustness and GMRES efficiency. Consolidating test systems (hypothetical and actual) of difficult convergence associated with extremely high loaded, is also part of research to create s cenarios close to reality, or that may occur in practice. The primary purpose of the inclusion of FACTS is to assess the impact that these devices can cause the Jacobian matrix. These characteristics are informed through eigenvalues and conditioning number. In addition, we propose an iterative solver developed in MATLAB platform for power flow studies and a detailed investigation of the influence of the reordering and the e limination of non-null elements in the quality of the preconditioner of incomplete factors. The proposed methodology was applied to hypothetical and real systems with FACTS controllers, and the results of the experiments showed the greater efficiency of the iterative solver GMRES in most simulations. It was found that the larger the size of the electrical system and the worse their numeric characteristics, the better its performance.
Neste Trabalho é investigado o desempenho do Método GMRES em estudos de Fluxo de potência extremamente carregados, mal condicionados e incluindo Controladores FACTS, enfocando matrizes Jacobianas com elevados números de condicionamento e autovalores reais próximos de zero, a fim de consolidar virtudes do GMRES na solução de problemas mal-condicionados. A apartir destas informações será possível estabelecer cenários de operação que poderão indicar pontos de robustez e eficiência do GMRES. A consolidação de sistemas-teste (hipotéticos e reais) de difícil convergência associados a carregamentos extremamente elevados, também faz parte das investigações para criar cenários próximos da realidade, ou seja, que possam ocorrer na prática. O objetivo primário da inclusão de FACTS está em avaliar o impacto que estes equipamentos podem causar na matriz Jacobiana. Estas características são informadas através de autovalores e número de condicionamento. Além disso, propõe-se um solucionador iterativo desenvolvido na plataforma MATLAB para estudos de fluxo de potência e uma investigação detalhada da influência do reordenamento e da eliminação de elementos não-nulos na qualidade do pré-condicionador de fatores incompletos. A metodologia proposta foi aplicada em sistemas hipotéticos e reais com Controladores FACTS, e os resultados dos experimentos mostraram a maior eficiência do solucionador iterativo GMRES em grande parte das simulações realizadas. Verificou-se que, quanto maior a dimensão do sistema elétrico e quanto pior suas características numéricas, melhor seu desempenho.
16
Mattsson, Josephie. "Technical Analysis of Flax Fiber Reinforced Polypropylene : Prerequisites for Processing and Recycling." Thesis, Karlstads universitet, Fakulteten för teknik- och naturvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-32352.
Full textAbstract:
Nowadays, when environmental concerns are becoming increasingly important are there great interest in natural materials and recyclability. The possibility of reusing materials with maintained mechanical properties are essential for sustainability. Today produced approximately 90,000 tons of natural fiber reinforced composites in Europe of those are 40,000 tons compression molded of which the automotive industry uses 95%. Natural fiber reinforced composites is recyclable and therefore interesting in many applications. Also, natural fiber reinforced composites is inexpensive, light in weight and shows decent mechanical properties which makes them attractive to manufactures. However, the problem with natural fiber reinforced composites is the poor adhesion between fiber and matrix, the sensitivity of humidity and their low thermal stability. Those problems could be overcome by addition of compatibilizer and reactive filler. This study will examine the technical requirement in order to develop a sustainable and recyclable biocomposite. It investigates the composition of matrix (polypropylene), fiber (flax), compatibilizer (maleic anhydride grafted polypropylene) and reactive filler (CaO) in order to obtain various combinations of stiffness, strength and processability. The two main methods used for preparing samples were compounding and injection molding. Results shows that 20 wt% flax was the optimal fiber content and that maleic anhydride grafted polypropylene is a very good compatibilizer by enhancing the strength significant. Surprisingly was the strength impaired due to the addition of CaO. The composition of 20 wt% flax, 1 wt% maleic anhydride grafted polypropylene and 79 wt% polypropylene is the technically most favorable composition.
17
Bastos, Bernardo Campbell. "Aplicação de lean manufacturing em uma linha de produção de uma empresa do setor automotivo." Universidade de Taubaté, 2012. http://www.bdtd.unitau.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=569.
Full textAbstract:
PSA Peugeot Citroën, a French automaker, has one plant in Brazil, located in Porto Real, Rio de Janeiro. This factory mounts 29 vehicles / hour of eight different models, four models of Peugeot and Citroën brand four. This great variety of models generates complexity in the production process and wide range of parts. This study aims to analyze the impact of diversity, illustrate wasteful standard concept of 3MUs (MUDA, MURI, MURA) and present a study of reducing overall diversity. This will be used to apply the tools and techniques of `Lean Manufacturing Concept. The Lean production system, which basically seeks to eliminate waste, presents several concepts that can and should be applied in studies of eliminating diversity. Among the concepts that can be used stand out studies Time and Methods, SMED, 5S, Kanban, Value Stream Mapping and Kaizen and Poka-Yoke. Through analysis of cases will demonstrate that reducing the diversity of parts and reduce costs, avoid waste and adding a number of benefits, impacts directly on the entire production chain of the automaker. The reduction of diversity interferes with logistics (transport, handling, storage, control), quality (robustness of process variability), production (surface, rework), systems (complex document base, variety of systems), engineering (equipment, investments, solutions) and suppliers (setups, inventories). Therefore, this work is of extreme importance and relevance for companies with a high level of competitiveness, such as assemblers, stay ahead in the job market and offer the best value for money offers.A PSA Peugeot Citroën, montadora de origem francesa, possui uma única fábrica no Brasil, localizada em Porto Real, Rio de Janeiro. Essa fábrica monta 29 veículos/hora de oito modelos distintos, sendo quatro modelos da marca Peugeot e quatro da marca Citroën. Essa grande variedade de modelos gera uma complexidade no processo produtivo e grande diversidade de peças. Esta dissertação tem como objetivo analisar o impacto da diversidade, exemplificar os desperdícios no padrão do conceito dos 3MUs (MUDA, MURI, MURA) e apresentar um estudo de redução da diversidade geral. Para isso, será utilizada a aplicação das ferramentas e técnicas do `Lean Manufacturing Concept. O sistema de produção Lean, que basicamente busca a eliminação de desperdícios, apresenta diversos conceitos que podem e devem ser aplicados nos estudos de eliminação da diversidade. Entre os conceitos que podem ser utilizados, destacam-se Estudos de Tempos e Métodos, SMED, 5S, Kanban, Mapeamento de Fluxo de Valor e Poka-Yoke e Kaizen. Através da análise de casos, se mostra que a redução da diversidade de peças, além de reduzir custos, evitar desperdícios e agregar uma série de benefícios, impacta diretamente em toda a cadeia produtiva da montadora. A redução da diversidade interfere na logística (transporte, movimentação, armazenagem, controle), na qualidade (robustez do processo, variabilidade), na produção (superfície, retrabalhos), nos sistemas (complexa base documental, variedade de sistemas), na engenharia (equipamentos, investimentos, soluções) e nos fornecedores (setups, estoques). Portanto, a presente dissertação é de extrema importância e relevância para que empresas com alto nível de competitividade, como as montadoras, permaneçam a frente no mercado de trabalho e ofereçam as melhores ofertas de custo-benefício.
18
Derin, Alan. "När det gäller epidemier har man oddsen emot sig : En komparativ historisk undersökning mellan spanska sjukan och Coronaviruset." Thesis, Södertörns högskola, Lärarutbildningen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-46126.
Full textAbstract:
More than a hundred years ago, the world was affected by the infamous pandemic virus, the Spanish flu, which lasted from 1918 to 1920. During this period, the First World War broke out. In the spring of 2020, the world was affected by a new pandemic virus called the Coronavirus (COVID-19). For the people who lived during 1918–1920 and the present, each virus has had enormous repercussions on their own lives and safety. For each epidemic, it has meant the political and economic stability in the world has been exposed. The world from then and now differs immensely from each other. Today, there are alternative opportunities to replace the regular lessons with digital connection. This study will make a historical comparative study between the Spanish flu and the coronavirus. In this study, two magazines aimed at teachers will be selected for each pandemic. This is done to see how the schools were affected by each epidemic, what measures were taken against the infection and what difficulties arose with it.
19
Nicodemo, Luiz Gustavo Grossi. "Um método para direcionar a implantação das ferramentas lean = uma aplicação numa empresa automotiva." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/264550.
Full textAbstract:
Orientador: Paulo Corrêa LimaDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica
Made available in DSpace on 2018-08-18T11:47:36Z (GMT). No. of bitstreams: 1 Nicodemo_LuizGustavoGrossi_M.pdf: 2943348 bytes, checksum: 500fcfbed0c132f1e779eebf78bca027 (MD5) Previous issue date: 2005
Resumo: Este trabalho apresenta uma metodologia para o direcionamento de projetos de melhoria nas empresas com base nas ferramentas do Sistema Toyota de Produção. Muito esforço têm sido despendido pelas empresas para alcançar resultados significativos em projetos de melhoria justamente pela não utilização de métodos estruturados de direcionamento destes projetos. O modelo metodológico proposto utiliza a integração entre o Mapa de Fluxo de Valor, o Balanced Scorecard, e o guia de produção enxuta da empresa como ferramenta para garantir a melhor relação possível entre custo e benefício alcançado nos projetos de melhoria. A validação do modelo se dá através de um projeto de implementação coordenado pelo autor, que utiliza esta metodologia durante mais de um ano em uma empresa de autopeças, e ao final do trabalho apresenta os ganhos referentes à aplicação do método
Abstract: This work presents a methodology to drive business improvement projects based on Toyota Production System tools. A lot of efforts are being spent by the companies to reach significant results on improvements projects because they do not utilize structured methods to drive these projects. The methodological model proposed uses the integration between the Value Stream Map, the Balanced Scorecard, and the Lean Production Guide of the company as a tool to assure the best possible relation between cost and reached benefits on improvements projects. The validation of the model occurs through an implementation project coordinated by the author, who applied this methodology for more than a year in an auto parts company and at the end presents the gains related to the application of the method
Mestrado
Materiais e Processos de Fabricação
Mestre em Engenharia Mecânica
20
Silva, Alessandro Lucas da. "Proposta de estudo de sistematização da implantação de sistemas Kanban no contexto da produção enxuta." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/18/18140/tde-07082017-102529/.
Full textAbstract:
\"Houve época em que as empresas podiam ser organizações focadas nos próprios processos produtivos e comerciais, pressionando o mercado a se adaptar a suas necessidades ou características, de acordo com o modelo de negócios por elas praticado. Na medida em que a sociedade e o mercado se alteraram em profundidade e complexidade, exigindo ao mesmo tempo melhores produtos, mais resultados e ganhos crescentes, as empresas passaram a sentir a necessidade de se envolver num processo contínuo de melhoria\", (PINEDO, 2003). Devido ao processo de globalização produtiva os concorrentes passaram a pressionar muito mais duramente, pelo fato espantoso de que o espaço de mercado passou a ser o mundo inteiro. Defeitos e atrasos na entrega dos produtos são mazelas não mais aceitas pelos consumidores. A crescente exigência destes por produtos customizados e entregas rápidas tem provocado um litígio entre as empresas e o tradicional sistema de produção em massa, que muitas vezes não consegue atingir as expectativas dos clientes. Para se adaptarem a esse ambiente competitivo, as empresas de manufatura, seguindo os passos da indústria automobilística, estão cada vez mais utilizando os conceitos e técnicas da Produção Enxuta, ou seja, produzindo em resposta a demandas específicas, somente quando necessário, controlando a qualidade do produto e do prazo de entrega, e ao mínimo custo. Nesse sentido, o objetivo desse trabalho é propor um método de implantação de sistema Kanban que possa auxiliar as organizações a utilizarem esta ferramenta da Produção Enxuta, retirando dessa os maiores benefícios possíveis, como redução do inventário, melhoria do sistema de gerenciamento, redução de atrasos em entregas, entre outros. Esse método deverá servir como base de orientação para os envolvidos num processo de implantação de Kanban.\"There were time where the companies could be organizations directed in the proper productive and commercial processes, pressuring the market to adapt its necessities or characteristics, in accordance with the model business-oriented for them practised. In the measure where the society and the market have modified in depth and complexity, demanding at the same time better products, more increasing results and profits, the companies had started to feel the necessity of involving in a continuous process of improvement\" (PINEDO, 2003). In consequence of the process of globalization\'s productive the competitorshad started to pressure much more hardly, for the amazing fact that the market space started to be the entire world. Defects and delays in the delivery of the products are problems not more accepted for the consumers. The increasing requirement of these for specific products and special deliveries has provoked a litigation between the companies and the traditional system of mass production, that many times do not obtain to reach the expectations of the customers. To be detached to this competitive environment, the companies of manufacture, following the steps of the automobile industry, are each time more using the concepts and techniques of the Lean Production, or either, producing in reply the specific demands, only when necessary, controlling the stated period and product quality of delivery, and minimum cost. In this direction, the objective of this work isto consider a method of system implantation Kanban that it can assist the organizations to use this tool of the Lean Production, removing that the biggest possible benefits, as reduction of inventory, improvement of the management system, reduction of delays in deliveries, among others. This method will have to serve as base of orientation for the involved ones in a process of Kanban\'s implantation.
21
Choi, Keum-Ran. "3D thermal mapping of cone calorimeter specimen and development of a heat flux mapping procedure utilizing an infrared camera." Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-020205-215634/.
Full textAbstract:
Dissertation (Ph.D.)-- Worcester Polytechnic Institute.Keywords: temperature measurement; heat flux maps; Cone Calorimeter; three-dimensional heat conduction; fire growth models; retainer frame; ceramic fiberboard; edge effect; one-dimensional heat conduction; heat flux mapping procedure; infrared camera; specimen preparation; edge frame; one-dimensional heat conduction model; thermal properties. Includes bibliographical references (p.202-204).
22
Pavanelli, Tais Francisco [UNIFESP]. "Avaliação da produção de citocinas inflamatórias apos estimulação por lipoproteína L32(LipL32), lipopolissacarídeo (LSP) e lipopeptídeo ativador de monócitos-2 (MALP-2) e expressão de receptores de superfície em monócitos de pacientes com leptospirose." Universidade Federal de São Paulo (UNIFESP), 2008. http://repositorio.unifesp.br/handle/11600/24401.
Full textAbstract:
Made available in DSpace on 2015-12-06T23:47:53Z (GMT). No. of bitstreams: 0
Previous issue date: 2008A leptospirose constitui uma importante zoonose, encontrada em regiões de clima tropical, ocorrendo principalmente em épocas chuvosas. O controle da infecção depende do adequado reconhecimento do microorganismo pelos receptores de reconhecimento de padrão de patógenos, os TLRs, presentes nas células do sistema imune inato do hospedeiro. A ativação dos TLRs é fundamental para o desencadeamento da resposta inflamatória, mediadora da resposta de proteção e de lesão no processo infeccioso. Objetivos: Avaliar a expressão dos receptores TLR2, TLR4 e CD14 na superfície de monócitos e a resposta in vitro aos estímulos LipL32 (extraído de Leptospira sp.), MALP-2 (antígeno sintético de Mycoplasma fermentans) e LPS (antígeno extraído de Salmonella abortus equi) ligantes dos TLRs, medida pela produção de citocinas, em pacientes com leptospirose. Métodos: Foram incluídos 07 pacientes com quadro clínico e laboratorial de leptospirose e 07 voluntários sadios, utilizados como controle. As células mononucleares do sangue periférico (CMSP) foram separadas utilizando ficoll-paque, congeladas e armazenadas em nitrogênio líquido. Após descongelamento, verificação da viabilidade e acerto da concentração de células para 1x106 células/mL foi mensurada a expressão de TLR2, TLR4 e CD14 na superfície de monócitos. O restante da suspensão de células foi incubada por 6 horas com os estímulos de 1000ng/mL de LipL32, 0,4U/mL de MALP-2 ou 100ng/mL de LPS. Após a primeira hora de incubação foi adicionado monensina para bloqueio da secreção de citocina. Em seguida, as CMSP foram marcadas com CD14, fixadas, permeabilizadas e expostas aos anticorpos anti-IL-6 e anti-TNF-α para detecção intracelular da produção destas citocinas inflamatórias nos monócitos. Foram adquiridos 10.000 eventos combinado-se morfologia e positividade para CD14 em citometria de fluxo. Resultados: Não foi observada diferença significativa na resposta inflamatória entre pacientes com leptospirose e voluntários sadios quando CMSP foram estimuladas in vitro com MALP-2 e LipL32 para indução da produção de citocinas inflamatórias (IL-6 e TNF-α) em monócitos. Todavia, a produção de TNF-α foi menor após estímulo com LPS (p=0,035), o que não ocorreu com a produção de IL-6. Em relação à expressão de receptores de superfície, foi observado aumento da expressão de TLR2 (p=0,025) na superfície de monócitos dos pacientes, porém não houve diferença na expressão de TLR4 e CD14. Conclusões: Neste estudo demonstramos que a capacidade de reconhecimento de antígenos pelos monócitos do sangue periférico de pacientes com leptospirose está preservada ou aumentada. Além disso, observamos que a produção de citocinas inflamatórias frente a antígeno da própria Leptospira (LipL32) e outro antígeno agonista de TLR2 (MALP-2) está mantida. Entretanto, a produção de citocina inflamatória frente ao LPS (agonista de TLR4) mostrou-se complexa podendo estar influenciada pela tolerância cruzada.
The Leptospirosis is one of the world's most important zoonoses, found in regions of tropical climate, occurring mainly in rainy seasons. The control of infection depends on the proper recognition of the microorganism by receptors for recognition of patterns of pathogens, the TLRs present in the cells of the innate immune system of the host. The activation of TLRs is crucial for triggering the inflammatory response, mediator of the response of protection in case of injury and infection. Objectives: To evaluate the expression of receptors TLR2, TLR4 and CD14 on the monocytes surface in vitro and response to stimuli LipL32 (extracted from Lestospira sp.), MALP-2 (synthetic antigen of Mycoplasma fermentans) and LPS (antigen extracted from bacteria-gram negative) binders of TLRs, as measured by production of cytokines in patients with leptospirosis. Methods: 07 patients with clinical and laboratory of leptospirosis were included and 07 healthy volunteers, used as controls. The peripheral blood mononuclear cells (PBMC) were separated using ficoll-paque, frozen and stored in liquid nitrogen. After thawing, checking the feasibility and wisdom of the concentration of cells to 1x106 células/mL was measured the expression of TLR2, TLR4 and CD14 on the monocytes surface. The rest of the cell suspension was incubated for 6 hours with the stimuli of 1000ng/mL of LipL32, 0.4 U / mL of MALP-2 or 100ng/mL of LPS. After the first hour of incubation was added monensin for blocking the secretion of cytokine. Then the PBMC were stained with CD14, set, permeabilizaded and exposed to anti-IL-6 and anti-TNF-α for detection of intracellular production of inflammatory cytokines in monocytes. They were acquired 10,000 events combined to morphology and positive for CD14 in flow cytometry. Results: There was no significant difference in the inflammatory response among patients with leptospirosis and healthy volunteers when PBMC were stimulated in vitro with MALP-2 and LipL32 to induce the production of inflammatory cytokines (IL-6 and TNF-α) in monocytes. However, the production of intracellular of TNF-α was lower after stimulation with LPS (p = 0035), which did not occur to the production of IL-6. Regarding the expression of surface receptors, it was observed increased expression of TLR2 (p = 0025) on the monocytes surface of patients, but there was no difference in the expression of TLR4 and CD14. Conclusions: This study demonstrated that the ability of recognition of antigens by peripheral blood monocytes of patients with leptospirosis is preserved or increased. Also, we observed that the production of inflammatory cytokines in front of the Leptospira antigen (LipL32) and another antigen agonist of TLR2 (MALP-2) is maintained. Meanwhile, the production of inflammatory cytokine front of LPS (agonist of TLR4) proved to be complex may be influenced by cross tolerance.
BV UNIFESP: Teses e dissertações
23
Halaoua, Khaled. "Quelques solveurs pour les opérateurs de convection et leur application à la mécanique des fluides diphasiques." Cachan, Ecole normale supérieure, 1998. http://www.theses.fr/1998DENS0019.
Full textAbstract:
Les modèles diphasiques de base sont non hyperboliques ; ils conduisent à des problèmes linéarisés mal posés. Dans cette thèse, nous cherchons des méthodes numériques qui soient capables de calculer des solutions approchées à ces problèmes. Nous généralisons d'abord des méthodes qui ont été éprouvé pour les systèmes hyperboliques. Nous construisons, ensuite, des schémas hybrides à partir des précédents via un limiteur de flux qui est adapté au cas non hyperbolique. Ce limiteur nous permet d'obtenir un schéma stable même dans le cas non hyperbolique non linéaire. Nous avons teste ces schémas sur les deux modèles de base, a quatre et six équations. Les résultats montrent que, dans le cas des écoulements diphasiques, il n'est pas indispensable de rendre ces modèles hyperboliques par la prise en compte de différents termes stabilisants.
24
Delgado, Jessica Antonio [UNESP]. "A combinação dos métodos de barreira e de barreira modificada na resolução do problema de fluxo de potência ótimo reativo." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/142848.
Full textAbstract:
Submitted by JÉSSICA ANTONIO DELGADO null (jessica_dellgado@hotmail.com) on 2016-08-05T13:36:45Z
No. of bitstreams: 1
DISSERTACAO_FINAL0308.pdf: 4117025 bytes, checksum: 0bc23567e553d5dba25e546bbeba3e55 (MD5)Rejected by Ana Paula Grisoto (grisotoana@reitoria.unesp.br), reason: Solicitamos que realize uma nova submissão seguindo as orientações abaixo: A data de defesa informada na capa e folha de rosto do trabalho está diferente da data que consta na folha de aprovação. Corrija estas informações e realize uma nova submissão contendo o arquivo correto. Agradecemos a compreensão. on 2016-08-09T17:15:33Z (GMT)
Submitted by JÉSSICA ANTONIO DELGADO null (jessica_dellgado@hotmail.com) on 2016-08-09T20:16:39Z No. of bitstreams: 1 DISSERTACAO_FINAL0908.pdf: 4117292 bytes, checksum: 2fa555b044c52407e59e19d3d51f664d (MD5)
Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-08-10T14:41:21Z (GMT) No. of bitstreams: 1 delgado_ja_me_bauru.pdf: 4117292 bytes, checksum: 2fa555b044c52407e59e19d3d51f664d (MD5)
Made available in DSpace on 2016-08-10T14:41:21Z (GMT). No. of bitstreams: 1 delgado_ja_me_bauru.pdf: 4117292 bytes, checksum: 2fa555b044c52407e59e19d3d51f664d (MD5) Previous issue date: 2016-06-10
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Este trabalho propõe uma abordagem que utiliza uma combinação de métodos baseados na função barreira logarítmica e barreira logarítmica modificada para a resolução do problema de Fluxo de Potência Ótimo Reativo. Na abordagem proposta as restrições de desigualdade são transformadas em igualdade introduzindo as variáveis de folga, as quais são tratadas pela função barreira logarítmica ou pela função barreira logarítmica modificada e as restrições de igualdade são tratadas pelos multiplicadores de Lagrange. Estes métodos são utilizados em duas etapas. Inicialmente aplica-se o método baseado na função barreira logarítmica até que um critério de transição seja satisfeita. Depois aplica-se o método baseado na função barreira logarítmica modificada até que a condição de convergência seja satisfeita. Testes numéricos utilizando os sistemas elétricos de 3 barras e IEEE 14, 30, 57 e 118 barras indicam que o método é eficiente na resolução do problema Fluxo de Potência Ótimo Reativo. Uma comparação dos resultados obtidos pela abordagem proposta com os dos métodos de barreira logarítmica e de barreira logarítmica modificada separadamente é realizada.
This work proposes an approach that uses a combination of methods based on loga-rithmic barrier function and modi˝ed logarithmic barrier function for the resolution of the reactive optimal power ˛ow problem. In this proposed approach the inequality cons-traints are transformed into equalities by adding the slack variables, which are handled by logarithmic barrier function or modified logarithmic barrier function, and the equality constraints are handled by means of Lagrange multipliers. These methods are used in two steps. Initially, the method based on the logarithmic barrier function is applied until the stop condition is satisfied. After the method based on modified logarithmic barrier function is used until the convergence condition is satisfied. Numerical tests carried out with the 3 bus, IEEE 14, 30, 57 and 118 bus electrical systems indicate that the proposed approach is efficient in the resolution of the reactive optimal power flow problem. The results obtained by the proposed approach were compared with the logarithmic barrier method and the logarithmic barrier method modified, separately.
25
Parot, Jeremie. "Développement méthodologique du fractionnement par couplage flux / force (AF4) et spectroscopie optique pour l'étude de la matière organique dissoute aquatique : application aux estuaires de Seine et de Gironde." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0363/document.
Full textAbstract:
La matière organique dissoute (MOD) est constituée d’un mélange hétérogène et complexe de molécules. Elle intervient dans de nombreux processus physiques, biologiques et chimiques dans les milieux aquatiques, et notamment dans les grands cycles biogéochimiques ou le transport et la biodisponibilité des contaminants.Ainsi un des enjeux actuels de nombreux domaines de recherche (chimie, écologie, océanographie) est de mieux comprendre et caractériser la MOD dans l’environnement. Dans ce contexte-là, l’objectif de ces travaux a été le développement d’une méthodologie analytique pour l’analyse et la séparation, en fonction de la taille, par fractionnement par couplage flux-force avec flux asymétrique (AF4) de la MOD. Le développement a principalement porté sur la phase mobile, le flux croisé, le temps de focus et l’utilisation d’étalons organiques proches de la MOD, permettant de calculer sa masse moléculaire moyenne.Cette méthode optimisée, couplée à un détecteur UV/Vis, équipée d’une membrane de 1kDa, d’un espaceur de 490μm et d’une phase mobile de 5mM en tampon phosphate a permis l’étude de la dynamique de la MOD.L’application de cette méthode couplée aux techniques de spectroscopie optique (absorbance et fluorescence) a permis l’étude de la MOD dans les estuaires de Seine et de Gironde mettant en avant les effets de la marée et des saisons sur la taille et le type de MOD.De plus, différentes approches statistiques ont été développées afin de mieux appréhender les multiples variables (analytiques ou environnementales) et notamment les modèles de régression linéaire ou les cartes auto-organisatrices de KohonenDissolved organic matter (DOM) is a heterogeneous and complex mixture of molecules. It is involved in many physical, biological and chemical processes in aquatic ecosystems, especially in the major biogeochemical cycles or transport and bioavailability of contaminants.Thus one of the current issues in many areas of research (chemistry, ecology, oceanography) is to better understand and characterize DOM in the environment. In this context, the aim of this work was the development of an analytical methodology for DOM analysis and separation, depending on its size, by asymmetrical flow field-flow fractionation (AF4). The development focused on the mobile phase, the cross-flow, the focus time and the use of organic macromolecules standards close to DOM, in order to calculate its molecular weight.This optimized method, coupled with a UV/Vis detector, equipped with a 1kDa membrane, a 490μm spacer and a mobile phase of 5 mM phosphate buffer allowed us to study the MOD dynamics in estuarine environments.The application of this method coupled to optical spectroscopy techniques (absorbance and fluorescence) permitted the study of MOD in the Seine and Gironde estuaries and to highlight the tidal and the seasonal effects on the size and type of DOM.Furthermore, different statistical approaches have been developed to better understand the multiple variables (analytical or environmental), especially linear regression models or self-organizing maps (Kohonen)
26
Nazareno, Ricardo Renovato. "Desenvolvimento e aplicação de um método para implementação de sistemas de produção enxuta." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/18/18140/tde-04042017-094532/.
Full textAbstract:
Este trabalho apresenta um método que visa auxiliar os agentes de mudança na condução de processos de implementação de sistemas de produção enxuta, cujo conceito tem sido largamente aplicado em diversas indústrias no Brasil, tais como a Ford, a GM, a Visteon, a Eaton, a Delphi, a Meritor, para citar apenas algumas. Entretanto, principalmente nas empresas que possuem produtos com grande variedade de peças e componentes, e com características distintas de demanda, muitos gerentes têm encontrado dificuldades ao tentar implementar um sistema de produção enxuta. O método é desenvolvido a partir de uma ampla revisão bibliográfica em torno do conceito de gerenciamento da mudança e melhoria organizacional, bem como dos princípios e das principais práticas e ferramentas enxutas. Com isso, são estudados com mais profundidade o mapeamento do fluxo de valor, a produção puxada, o sistema de controle Kanban e o layout celular. Em seguida, o método é validado empiricamente por meio de duas aplicações, a primeira numa empresa produtora de bebedouros e a segunda numa empresa produtora de tanques para armazenagem e resfriamento de leite.This work presents a method that aims to help the change agents in the Lean Production Systems implantation, whose concept has been applied in several industries in Brazil, such as Ford, GM, Visteon, Eaton, Delphi, Meritor, etc. However, mainly in the companies with great variety of goods and components, many managers have been difficulties to implement a lean production system. The method is developed from a wide bibliographical revision around change and improvement management concept, as well as lean production tools and techniques. It is studied value stream mapping, pull production, Kanban control system and cellular layout. The method is empirically validated in two applications, the first application is in a drinking fountain company, and the second one is in a tank of milk storage company.
27
van, Herel Ryan Marinus Johannes Wilhelmus Maria. "Wire Explosion via Electromagnetic Induction." Thesis, University of Canterbury. Electrical and Computer Engineering, 2011. http://hdl.handle.net/10092/6719.
Full textAbstract:
This research is aimed at exploding a wire via electromagnetic induction, with a preference for obtaining restrike of the exploding wire in a ring shape or otherwise.
Literature on both exploding wire and electromagnetic induction are introduced together. A mathematical framework to describe the wire explosion by induction is formulated from first principles using the idea of magnetic flux linkages. The environment in which the experiments took place is described, with reference to matters of laboratory safety and also measurement of transient electrical current and voltage in the wire explosion by induction. The results describe the approaches taken to explode a wire by induction to obtain a plasma conductor. Voltage and current data
are displayed and described. Throughout this work, there are long-exposure digital photographic images of the experiments taking place. These contribute to determining the outcome of experiments, and support the conclusions. Wires were exploded
by induction in an air-cored mutually coupled coils system, and restrike of those wires was achieved. Electrical characteristics of wire explosion by electromagnetic induction are displayed and discussed based on what is known about straight exploding
wires. Future works involving creation of plasma rings, electromagnetic thrust and exploding wires in vacuum are discussed.
28
Mesfioui, Abdelhalem ben Mehdi. "Contribution à l'étude des mécanismes mis en jeu dans les flux transmembranaires de neurotransmetteurs : Action de l'amphétamine, de la phényléthylamine et de la tranylcypromine sur la libération des catécholamines et l'activité des composantes du système de l'adénosine triphosphatase." Nancy 1, 1988. http://www.theses.fr/1988NAN10187.
Full textAbstract:
De façon classique, la libération des neurotransmetteurs au niveau synaptique implique un mécanisme d'exocytose nécessitant la médiation d'ions calcium. Cette libération peut se produire en absence de calcium extracellulaire ; elle dépend alors du gradient sodique trasmembranaire et sera modulée par tout paramètre affectant l'amplitude de ce gradient notamment l'activité (Na+,K+)-ATPasique, expression enzymatique de la pompe à sodium. Nous avons entrepris une analyse de ce mécanisme par une expérimentation in vivo et in vitro portant sur l'action de l'amphétamine et de composés apparentés (phényléthylamine et tranylcypromine) sur la libération des catécholamines au niveau du bulbe olfactif du rat adulte
29
Rizk, Joelle. "Étude et modélisation des conditions d'échanges dans les colonnes de distillation diabatiques : étude de la distribution de fluides." Phd thesis, École Nationale Supérieure des Mines de Paris, 2010. http://pastel.archives-ouvertes.fr/pastel-01003516.
Full textAbstract:
Les colonnes de distillation de l'air constituent l'un des procédés principaux de séparation des composants de l'air mais posent le problème des consommations énergétiques élevées. Dans le but de produire les quantités d'oxygène nécessaire pour les procédés d'oxycombustion à faibles coûts énergétiques, une colonne de distillation diabatique pour la séparation de l'air cryogénique est conçue et modélisée. Elle consiste en un échangeur tubes-calandre où les tubes constituent une première colonne opérant à basse pression et la calandre en constitue une deuxième opérant à haute pression. Les transferts de masse et de chaleur couplés sont modélisés et le fonctionnement de la colonne est simulé. Une analyse exergétique comparative entre trois types de colonnes de distillation d'air cryogénique montre que l'efficacité exergétique de la colonne diabatique conçue est 23 % fois plus élevée que celle des colonnes doubles conventionnelles. La distribution des mélanges dans les tubes et dans la calandre est un point clé dans le procédé de distillation dans l'échangeur tubes-calandre. Les différentes formes de mal répartition sont étudiées et des solutions proposées. Une colonne pilote est dimensionnée pour valider expérimentalement le concept théorique de la distillation diabatique de l'air cryogénique.
30
Maciel, Andrilene Ferreira. "Uma interpretação nebulosa dos mapas de Kohonen." Universidade Federal de Alagoas, 2008. http://repositorio.ufal.br/handle/riufal/823.
Full textAbstract:
The Data Mining techniques, based on the Kohonen self-organizing maps have been largely
used for classifying signals in several areas of expertise. Generally, the SOM network (Self-
Organizing Maps) is used to specify similarity relationships between objects by adopting cluster
analysis. The computational cost, data preparation and mathematical modeling can influence
the interpretation of results, in which those from the evaluation classes are among its
limitations. The Kohonen maps do not permit detailed evaluation of the class of objects, which
may however be defined by the class limits, in other words defining a measure that can link
when an object belonging to a particular class can migrate from one class to another . To adopt
this approach the solutions proposed in this Masters dissertation are designed to implement the
Kohonen self-organizing maps and the fuzzy logic to generate neighborhoods between classes
aimed at applying these techniques on a two-case study for classifying signals from potencial
power systems and Biomedical output signals adopting an interpretation of the Kohonen nebula
maps. The work is basically divided into three stages: the first which would be followed by a
review of the data-mining techniques and fuzzy logic shown in literature; the second focuses
on applying the classifier algorithm using artificial neural networks, specifically the usage of
neural networks as SOM data mining techniques to enable the classification of signals while
the third step demonstrates the SOM network fuzzy logic multidisciplinary approach as an
alternative tool of the data-mining methods.Fundação de Amparo a Pesquisa do Estado de Alagoas
As técnicas de mineração de dados baseadas nos mapas auto organizáveis de Kohonen têm sido bastante utilizada na classificação de sinais nas mais diversas áreas de conhecimento. Geralmente, a rede SOM (Self-Organizing Maps) é usada para especificar relações de similaridade entre objetos abordando análise de agrupamentos. O custo computacional, a preparação dos dados e modelagem matemática poderá influenciar na interpretação dos resultados, entre suas limitações encontram-se aquelas provenientes da avaliação das classes. Os mapas de Kohonen não permite avaliar de forma detalhada a classe dos objetos, os quais poderão está definidos pelo limite da classe, ou seja, definir uma medida que possa relacionar quando um objeto que pertença a uma classe particular possa migrar de uma classe para outra. Para adotar essa abordagem a solução proposta nesta dissertação de mestrado têm como objetivo aplicar os mapas auto-organizáveis de Kohonen e a lógica nebulosa para gerar as vizinhanças entre as classes visando aplicação dessas técnicas em dois estudos de casos na classificação dos sinais provenientes dos sistemas elétricos de potência e sinais biomédicos adotando uma interpretação nebulosa dos mapas de Kohonen. O trabalho se divide basicamente em três etapas: na primeira, será realizada uma revisão das técnicas de mineração de dados e da lógica nebulosa mostradas na literatura; na segunda, concentra-se aplicar o algoritmo classificador utilizando redes neurais artificiais, especificamente redes neurais SOM como técnica de mineração de dados para efetuar a classificação dos sinais; na terceira etapa demonstramos a abordagem multidisciplinar da rede SOM e da lógica nebulosa como uma ferramenta alternativa aos métodos de mineração de dados.
31
Bellas, Anastasios. "Détection d'anomalies à la volée dans des signaux vibratoires." Thesis, Paris 1, 2014. http://www.theses.fr/2014PA010020.
Full textAbstract:
Le thème principal de cette thèse est d’étudier la détection d’anomalies dans des flux de données de grande dimension avec une application spécifique au Health Monitoring des moteurs d’avion. Dans ce travail, on considère que le problème de la détection d’anomalies est un problème d’apprentissage non supervisée. Les données modernes, notamment celles issues de la surveillance des systèmes industriels sont souvent des flux d’observations de grande dimension, puisque plusieurs mesures sont prises à de hautes fréquences et à un horizon de temps qui peut être infini. De plus, les données peuvent contenir des anomalies (pannes) du système surveillé. La plupart des algorithmes existants ne peuvent pas traiter des données qui ont ces caractéristiques. Nous introduisons d’abord un algorithme de clustering probabiliste offline dans des sous-espaces pour des données de grande dimension qui repose sur l’algorithme d’espérance-maximisation (EM) et qui est, en plus, robuste aux anomalies grâce à la technique du trimming. Ensuite, nous nous intéressons à la question du clustering probabiliste online de flux de données de grande dimension en développant l’inférence online du modèle de mélange d’analyse en composantes principales probabiliste. Pour les deux méthodes proposées, nous montrons leur efficacité sur des données simulées et réelles, issues par exemple des moteurs d’avion. Enfin, nous développons une application intégrée pour le Health Monitoring des moteurs d’avion dans le but de détecter des anomalies de façon dynamique. Le système proposé introduit des techniques originales de détection et de visualisation d’anomalies reposant sur les cartes auto-organisatrices. Des résultats de détection sont présentés et la question de l’identification des anomalies est aussi discutéeThe subject of this Thesis is to study anomaly detection in high-dimensional data streams with a specific application to aircraft engine Health Monitoring. In this work, we consider the problem of anomaly detection as an unsupervised learning problem. Modern data, especially those is-sued from industrial systems, are often streams of high-dimensional data samples, since multiple measurements can be taken at a high frequency and at a possibly infinite time horizon. More-over, data can contain anomalies (malfunctions, failures) of the system being monitored. Most existing unsupervised learning methods cannot handle data which possess these features. We first introduce an offline subspace clustering algorithm for high-dimensional data based on the expectation-maximization (EM) algorithm, which is also robust to anomalies through the use of the trimming technique. We then address the problem of online clustering of high-dimensional data streams by developing an online inference algorithm for the popular mixture of probabilistic principal component analyzers (MPPCA) model. We show the efficiency of both methods on synthetic and real datasets, including aircraft engine data with anomalies. Finally, we develop a comprehensive application for the aircraft engine Health Monitoring domain, which aims at detecting anomalies in aircraft engine data in a dynamic manner and introduces novel anomaly detection visualization techniques based on Self-Organizing Maps. Detection results are presented and anomaly identification is also discussed
32
Li, Chung Mu, and 李俊穆. "A Discussion on School Microclimate Estimation Model with Heat Flux Accumulation Map - Urban Area of Kaohsiung as an Example." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/37959542909997110641.
Full textAbstract:
碩士樹德科技大學
建築與環境設計研究所
100
With the transformation of the domestic economic forms, leisure activities have flourished and people’s requirements for the quality of leisure environment have also improved. The campus is a common open green space in the rapid changing city currently which is often selected by city dwellers. In the past, impervious pavement design was often used in campuses of Taiwan, causing heat to be trapped in the pavement in Taiwan which enjoys a sunny climate throughout the year, thus resulting in an urban heat island. For campus planning and design, the effects and evaluation of pavement design on warm humid environment of campus can be used as a reference for current campus design method and as the decision for outdoor space improvement in future campuses, so as to improve the environmental quality of campus and realize sustainable development of campus. This research takes campuses in Zuoying District and Yanchao District of Kaohsiung as cases, choosing common natural and artificial pavements to conduct microclimatic survey of pavements and analog computation of hourly sunlight and shading, so as to discuss the tendency of various pavements according to the hourly environmental changes and build the estimation equation of microclimate environment of campus, hoping to provide a reference for future campus pavement planning. By field survey of campus pavement and integrating the tendencies of heating and heat dissipation, it finds that air temperature is susceptible to wind speed and is also related to campus plants. The heat absorption and dissipation speed of pavement material is depended on the thermal radiation temperature affected by the solar radiation. The pavement area has a direct influence on the accumulated total heat flux of the campus in each time interval. Campuses with larger planning area may have much higher heat flux than other estimation model campuses. As for the heat flux equation of campus pavement, future campus planning and design can adopt the microclimate estimation equation to estimate the microclimate temperature of anticipated planned campus, to serve as the suggestion for improving the campus pavement and plant configuration. Keywords: Heat Flux; Microclimate; Equation Estimate
33
Yang, Chih-Hung, and 楊智閎. "Phosphorus Flux of Reservoir Sediments-- Hsin-Shan and Shih-man Reservoir." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/68412537996255198504.
Full textAbstract:
碩士臺灣大學
環境工程學研究所
95
It has been demonstrated that phosphorus concentration is a limiting factor for the growth of planktons in reservoirs and lakes. High phosphorus concentration results in high rate of algae growth and eutrophic state of reservoirs. Bottom sediments have been identified as potential sink and source of phosphorus to the overlaying water. As a result, the understanding of the mechanisms and factors controlling phosphorus release flux from benthic sediment is needed. In the thesis, Hsin-shan Reservoir and Shih-men Reservoir were taken as our study sites for the investigation of sediment-water column interaction. The results of fractional extraction analysis of bottom sediments and settling matters show that organic-P and calcium-P dominate in Hsin-shan Reservoir and Shih-men Reservoir, respectively. Therefore, in Hsin-shan Reservoir, dissolved oxygen has great influence on the release of phosphorus from sediments because of its rich of ferric content in sediment. In contrast, in Shih-men Reservoir, dissolved oxygen may not affect the release of phosphorus since aluminum and calcium minerals dominate in sediment. Flux of total settling phosphorus collected by sediment traps ranged from 1.36 to 1.68 mg/m2/day in Hsin-shan Reservoir and 6.04 mg/m2/day in Shih-men Reservoir. For the reason above, settling flux in Shih-men Reservoir is influenced by external input significantly. Through the investigation of the phosphorus release flux under oxic or anoxic condition, the following results were observed: The release flux in oxic condition was about 0.10 and 0.13 mg/m2/day in Hsin-shan Reservoir and Shih-men Reservoir, respectively. Under anoxic condition, it was about 3.57 and 0.10 mg/m2/day in Hsin-shan Reservoir and Shih-men Reservoir, respectively. Mass balance for the annual external and internal phosphorus loading shows that released internal loading from bottom sediment has exceeded external loading in Hsin-shan Reservoir in 2006. However, internal phosphorus loading only accounts for 1.7% of the external loading in Shih-men Reservoir in the same year. So it is concluded that internal loading from sediments may have considerable impact on water quality in Hsin-shan Reservoir but minor impact in Shih-men Reservoir.
34
Dorka, Penny. "Modelling Batch and Fed-batch Mammalian Cell Cultures for Optimizing MAb Productivity." Thesis, 2007. http://hdl.handle.net/10012/3166.
Full textAbstract:
The large-scale production of monoclonal antibodies (MAb) by mammalian cells in batch
and fed-batch culture systems is limited by the unwanted decline in cell viability and
reduced productivity that may result from changes in culture conditions. Therefore, it
becomes imperative to gain an in-depth knowledge of the factors affecting cell growth and cell viability that in turn determine the antibody production. An attempt has been made to obtain an overall model that predicts the behaviour of both batch and fed-batch systems as a function of the extra-cellular nutrient/metabolite concentrations. Such model formulation will aid in identifying and eventually controlling the dominant factors in play
to optimize monoclonal antibody (MAb) production in the future.
Murine hybridoma 130-8F producing anti-F-glycoprotein monoclonal antibody was grown in D-MEM medium (Gibco 12100) with 2% FBS. A systematic approach based on Metabolic Flux Analysis (MFA) was applied for the calculation of intracellular fluxes for
metabolites from available extracellular concentration values. Based on the set of
identified significant fluxes (from MFA), the original metabolic network was reduced to
a set of significant reactions. The reactions in the reduced metabolic network were then combined to yield a set of macro-reactions obeying Monod kinetics. Half saturation constants were fixed empirically to avoid computational difficulties that parameter estimation for an over-parameterized system of equations would cause. Using Quadratic Programming, the proposed Dynamic Model was calibrated and model prediction was carried out individually for batch and fed-batch runs. Flux distribution for batch and fedbatch
modes were compared to determine whether the same model structure could be applied to both the feeding profiles. Correlation analysis was performed to formulate a
Biomass Model for predicting cell concentration and viability as a function of the extracellular metabolite concentrations in batch and fed-batch experiments. Quadratic
Programming was applied once again for estimation of growth and death coefficients in the equations for viable and dead cell predictions. The prediction accuracy of these model equations was tested by using experimental data from additional runs. Further, the Dynamic Model was integrated with the Biomass Model to get an Integrated Model capable of predicting concentration values for substrates, extracellular metabolites, and viable and dead cell concentration by utilizing only starting concentrations as input.
It was found that even though the set of significant fluxes was the same for batch and fedbatch operations, the order of these fluxes was different between the two systems. There was a gradual metabolic shift in the fed-batch system with time indicating that under conditions of nutrient limitation, the available energy is channeled towards maintenance rather than growth. Also, available literature with regard to cell kinetics during fed-batch
operation suggests that under nutrient limited conditions, the cells move from a viable, non-apoptotic state to a viable apoptotic state. This is believed to lead to variations in antibody production rates and might explain inaccurate predictions for MAb obtained from the model proposed in the current work. As a result more detailed analysis of the system and in particular, the switch from non-apoptotic to apoptotic state is required.
As a continuation of efforts to study the system in-depth, fluorescence imaging is
currently being applied as a tool to capture the changes in cell morphology along the
course of experimental batch and fed-batch runs. These experiments maybe able to
elucidate the transition from non-apoptotic to apoptotic cells and this information maybe
used in the future to improve the accuracy of the existing mathematical model.
35
Oliveira, Cidália Pereira de. "O contributo do mapeamento do fluxo de valor para a melhoria contínua : um estudo de caso na indústria automóvel." Master's thesis, 2013. http://hdl.handle.net/11067/971.
Full textAbstract:
Mestrado em GestãoExame Público realizado em 10 de Março de 2014
A atual situação económica reforça a necessidade de redução de custos industriais inerentes a matérias-primas, produtos acabados, assim como respetivos prazos de transformação (lead-times) e prazos de fornecimento (transit-times). Estas reduções são de extrema importância para as indústrias, assim como para as empresas prestadoras de serviços. Desta forma, os Gestores focam as suas atenções na pesquisa e análise de possíveis soluções para a redução de custos, de inventários, de defeitos e alocação de recursos humanos, possibilitando assim, a eliminação de atividades ou aquisições sem valor acrescentado para a empresa. É notório que esta área de investigação evidencia um crescimento fulminante, tendo por base o crescimento de 300% nas publicações científicas verificadas entre 2006 e 2011, na base de dados da ISI. No que concerne à revisão sistemática de literatura, foram selecionadas publicações científicas abrangendo a cadeia de valor, o Value Stream Mapping, o fluxo de informação e materiais, assim como a produção Lean. A amostra inicial era composta por 693 artigos científicos publicados na base de dados da ISI, num intervalo de 12 anos. Após uma seleção rigorosa, a amostra foi reduzida para 210 artigos científicos. De forma a permitir a replicabilidade do estudo foi elaborado um protocolo de revisão meticuloso. Os ficheiros foram extraídos através do Endnote X4, para ficheiros .xml. Posteriormente foram gerados mapas de análise através do RefViz, usando estatísticas descritivas e análises de conteúdo. Através de um mapa de fluxo de informação e materiais, nomeadamente o fluxo de valor, abrangendo todos os membros de uma cadeia de fornecimento a empresa poderá tornar-se mais dinâmica, funcional e bem-sucedida. Salientando que a aplicabilidade deste mapeamento já ultrapassou o seu “berço” originário, sabendo que tem demonstrado forte sucesso noutras áreas, para além das indústrias automóveis. Pretende-se averiguar de que forma o fluxo inerente à cadeia de abastecimento, está a ser abrangido pela revisão de literatura, para proceder à comparação de dados, entre a Revisão Sistemática de Literatura, e o Estudo de Caso realizado numa empresa da indústria automóvel. Para poder proceder ao cruzamento de dados, entre a Revisão Sistemática de Literatura, e a realidade prática, foram realizadas Entrevistas aos Gestores de Processo, assim como Observações Diretas ao seio produtivo. Com o intuito de se poder confirmar, se o mapeamento do Fluxo de Valor tem um contributo benéfico, no que concerne às reduções intrínsecas, permitindo consequentemente a melhoria contínua. Numa primeira fase foram realizadas as Entrevistas aos vários Gestores de Processo, seguindo-se as Observações Diretas em quatro momentos distintos. De forma a poder comparar a informação recebida durante as Entrevistas com a observada nas Observações Diretas, interligando posteriormente a informação do Estudo de Caso com a Revisão Sistemática de Literatura. Todo o fluxo deve ser rigorosamente analisado entre todos os membros da cadeia de abastecimento, de forma a poder manter todos os processos sustentáveis, trabalhando como parceiros para se tornarem mais competitivos e eficientes. Fornecedores e Clientes devem ser integrados neste mapeamento, para que uma visão abrangente de todo o fluxo de informação e materiais possa ser criada.
Having in mind the actual economic situation, reducing industrial costs related to the raw-materials, finished goods, such as lead-times and transit-times, assumes a key relevance for the whole industries and services, reflecting on their competitiveness. Bearing this in mind, special attention to this topic has been devoted beside managers, in order to find out how the costs, inventories, scraps and human resources, with no additional value, may be reduced. It is notorious, that this area of investigation is a highly growing area, having in mind the increase of 300% scientific papers verified between 206 and 2011 on the ISI database. Concerning the systematic literature review, of academic papers, these have been selected, covering the Value Chain, Value Stream Mapping, Material Information Flow Analysis and Lean Manufacturing. The initial sample covers 693 papers published in the ISI Database, with a timespan of 12 years. After a selective analyze, the sample was reduced into 210 papers. A review protocol was created in order to allow a meticulous study and to permit replicability. Through the Endnote X4, have been extracted the records to .xml files. Afterwards, have been created maps via RefViz, using descriptive statistics and content analysis. The importance of the Value Stream Map is becoming more and more evident, having in mind, that the application of this map has passed all the barriers of the industrial “cradle”, having already been implemented in the service area Based on an over viewing map, including all the participants of the supply-chain, to turn the company more dynamic, functional and well succeeded. Therefore the goal is to understand how the material and information flow are viewed and treated in the literature, in order to compare with the information extracted from the Case Study realized in an industrial company of the automotive sector. Therefore to crossover all the information, interviews with Process managers and several local observations of the production process have been done. In order to analyze the literature concerning the established goal, intending to find out, how the mapping of the information and material flow may drives to continuous improvement, identifying wastes, and long lead-times such as transit-times. Additionally, xthe opinion of each Process manager was included, in order to compare the answers with each other, such as with the literature review. The initial phase consisted in the interviews with the process managers, followed by the local observations, which have been done in four different periods, in order to allow the crossover of the information obtained in the interviews and the local observations. Therefore the information and material flow, should carefully be analyzed beside all the members of the supply chain, in order to maintain each Process sustainable. Suppliers and customers of a supply chain ought to be joined, in order to create a complete overview of the flow of material and information, working as partners in order to become more competitive and efficient.
36
Pickles, Sarah. "Uncovering the role of misfolded SOD1 in the pathogenesis of Amyotrophic Lateral Sclerosis." Thèse, 2015. http://hdl.handle.net/1866/13032.
Full textAbstract:
La sclérose latérale amyothrophique (SLA) est une maladie neurodégénérative charactérisée par la perte des neurones moteurs menant à la paralysie et à la mort. Environ 20% des cas familiaux de la SLA sont causés par des mutations de la superoxyde dismutase 1 (SOD1), conduisant vers un mauvais repliement de la protéine SOD1, ce qui a comme conséquence un gain de fonction toxique. Plusieurs anticorps spécifiques pour la forme mal repliée de la protéine ont été générés et utilisés comme agent thérapeutique dans des modèles précliniques. Comment le mauvais repliement de SOD1 provoque la perte sélective des neurones moteurs demeure non résolu. La morphologie, le bilan énergétique et le transport mitochondrial sont tous documentés dans les modèles de la SLA basés sur SOD1, la détérioration des mitochondries joue un rôle clé dans la dégénération des neurones moteurs. De plus, la protéine SOD1 mal repliée s’associe sélectivement sur la surface des mitochondries de la moelle épinière chez les modèles de rongeurs de la SLA. Notre hypothèse est que l’accumulation de la protéine SOD1 mal repliée sur les mitochondries pourrait nuire aux fonctions mitochondriales. À cette fin, nous avons développé un nouvel essai par cytométrie de flux afin d’isoler les mitochondries immunomarquées avec des anticorps spécifiques à la forme malrepliée de SOD1 tout en évaluant des aspects de la fonction mitochondriale. Cette méthode permettra de comparer les mitochondries portant la protéine SOD1 mal repliée à celles qui ne la portent pas. Nous avons utilisé un anticorps à conformation spécifique de SOD1, B8H10, pour démontrer que la protéine mal repliée SOD1 s’associe avec les mitochondries de la moelle épinière des rat SOD1G93A d’une manière dépendante du temps. Les mitochondries avec la protéine mal repliée SOD1 B8H10 associée à leur surface (B8H10+) ont un volume et une production excessive de superoxyde significativement plus grand, mais possèdent un potentiel transmembranaire comparable aux mitochondries B8H10-. En outre, la présence de la protéine mal repliée SOD1 reconnue par B8H10 coïncide avec des niveaux plus élevés de la forme pro-apoptotique de Bcl-2. L’immunofluorescence de sections de moelle épinière du niveau lombaire avec l’anticorps spécifique à la conformation B8H10 et AMF7-63, un autre anticorps conformationnel spécifique de SOD1, démontre des motifs de localisations distincts. B8H10 a été trouvé principalement dans les neurones moteurs et dans plusieurs points lacrymaux dans tout le neuropile. Inversement, AMF7-63 a marqué les neurones moteurs ainsi qu’un réseau fibrillaire distinctif concentré dans la corne antérieure. Au niveau subcellulaire, SOD1 possèdant la conformation reconnu par AMF7-63 est aussi localisée sur la surface des mitochondries de la moelle épinière d’une manière dépendante du temps. Les mitochondries AMF7-63+ ont une augmentation du volume comparé aux mitochondries B8H10+ et à la sous-population non marquée. Cependant, elles produisent une quantité similaire de superoxyde. Ensemble, ces données suggèrent qu’il y a plusieurs types de protéines SOD1 mal repliées qui convergent vers les mitochondries et causent des dommages. De plus, différentes conformations de SOD1 apportent une toxicité variable vers les mitochondries. Les protéines SOD1 mal repliées réagissant à B8H10 et AMF7-63 sont présentes en agrégats dans les fractions mitochondriales, nous ne pouvons donc pas prendre en compte leurs différents effets sur le volume mitochondrial. Les anticorps conformationnels sont des outils précieux pour identifier et caractériser le continuum du mauvais repliement de SOD1 en ce qui concerne les caractéristiques biochimiques et la toxicité. Les informations présentes dans cette thèse seront utilisées pour déterminer le potentiel thérapeutique de ces anticorps.Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the loss of motor neurons resulting in paralysis and death. Approximately 20% of familial ALS cases are caused by mutations in superoxide dismutase (SOD1), which leads to misfolding of the SOD1 protein, resulting in a toxic gain of function. Several antibodies have been generated that are specific for the misfolded form of the protein, and have been used as therapeutics in pre-clinical models. How misfolded SOD1 provokes a selective loss of motor neurons remains unresolved. Mitochondrial morphology, bioenergetics and transport are all documented is SOD1-mediated ALS models, thus mitochondrial impairment plays a key role in motor neuron degeneration. Moreover, misfolded SOD1 selectively associates with the surface of spinal cord mitochondria in ALS rodent models. We hypothesize that the accumulation of misfolded SOD1 on mitochondria could impair mitochondrial function. To this end, we developed a novel flow cytometric assay to immunolabel isolated mitochondria with misfolded SOD1 antibodies while also evaluating aspects of mitochondrial function. This method will allow for a comparison of mitochondria bearing misfolded SOD1 to those without. We utilized the B8H10 conformation specific SOD1 antibody to demonstrate that misfolded SOD1 associates with SOD1G93A rat spinal cord mitochondria in a in a time dependent manner. Mitochondria with B8H10-reactive misfolded SOD1 associated with their surface (B8H10+) have a significantly larger volume and produce excessive amounts of superoxide, but have a similar transmembrane potential compared to B8H10- mitochondria. In addition, the presence of B8H10-reactive misfolded SOD1 coincides with higher levels of the pro-apoptotic form of Bcl-2. Staining of lumbar spinal cord sections with both B8H10 and another conformation specific SOD1 antibody, AMF7-63, yielded distinct localization patterns. B8H10 was found predominantly in motor neurons and numerous puncta throughout the neuropil. Conversely, AMF7-63 marked motor neurons as well as a distinctive fibrillar network that was concentrated in the anterior horn. At the subcellular level, AMF7-63-reactive misfolded SOD1 also localized to the mitochondrial surface of spinal cord mitochondria in a time-dependent manner. AMF7-63+ mitochondria have an increased volume compared to B8H10+ mitochondria and the unlabelled subpopulation. However, they produce similar amounts of superoxide. Together, these data suggest that there are multiple species of misfolded SOD1 that converge at the mitochondria to cause damage. Moreover, different SOD1 conformations may ellicit varying toxicities towards mitochondria. Both B8H10 and AMF7-63-reactive misfolded SOD1 are present in aggregates in mitochondrial fractions and can therefore not account for any different effects produced in terms of mitochondrial volume. Conformational antibodies are invaluable tools to identify and characterize the continuum of misfolded SOD1 species with regards to biochemical characteristics and toxicity. The information presented in this thesis will be used in determining the future therapeutic potential of these antibodies.
37
Braga, Alexandre de Assunção. "Passagem do Meio - Um projeto de visualização de informação para representar o tráfico transatlântico de escravos e a migração forçada de mais de dez milhões de africanos às Américas." Master's thesis, 2018. http://hdl.handle.net/10316/86179.
Full textAbstract:
Dissertação de Mestrado em Design e Multimédia apresentada à Faculdade de Ciências e TecnologiaNeste trabalho propõe-se o desenvolvimento de representações e visualizações de informação referentes a fluxos. Em particular, estudamos e trabalhamos sobre a base de dados do projeto Voyages: The Trans-Atlantic Slave Trade Database, que documenta os fluxos de escravos transportados no contexto do tráfico transatlântico dos séculos xvi a xix. Sendo este projeto parte de um Mestrado que tem como proposta fundamental a combinação da formação em design de comunicação e de interação com competências de desenvolvimento informático, buscamos na solução combinar um exercício de design original com componentes de realização apoiadas em métodos e técnicas informáticas.Esse objetivo foi atingido através do desenvolvimento de um artefato de visualização de informação georreferenciado, na forma de um flow map interativo, utilizando técnicas para converter uma base de dados complexa em informação inteligível para um público-alvo amplo.O projeto contemplou o desenvolvimento de uma identidade visual, com escolhas de design justificadas e adequadas à temática e ao aspecto funcional da visualização de informação efetiva.Os artefato de visualização desenvolvido foi utilizado na composição de uma animação orientada por dados, que complementa a informação do artefato.Espera-se que o trabalho desenvolvido neste projeto tenha contribuido ao desenvolver novos modelos de visualização de fluxos e ao despertar interesse, ampliar consciência e gerar conhecimento mais profundo a respeito do tráfico transatlântico de escravos e seus impactos.
This paper proposes the development of representations and visualizations of information regarding flows. In particular, we study and work with the database of the Project Voyages: The Trans-Atlantic Slave Trade Database, which documents the flows of slaves transported in the context of transatlantic slave trade from the sixteenth to the nineteenth centuries. Being part of a Master's Degree that has as fundamental proposal the combination of training in communication and interaction design with computer development skills, we produced an original exercise of design supported by computer-based methods and techniques. This goal was achieved through the development of a georeferenced information visualization artifact in the form of an interactive flow map using techniques to convert a complex database into intelligible information for a broad audience.The project included the development of a visual identity, with design choices justified and appropriate to the theme and functional aspect of effective information visualization. The developed visualization artifact was used in the composition of a data-driven animation, which complements the artifact information. We believe we have succeeded in developing a solution with justified choices that satisfactorily combines technological with visual design components producing an appealing solution that effectively creates awareness and broadens knowledge about a tragic and fundamental chapter in the history of mankind. It is also expected that the work developed in this project contributes to the development of new models of visualization of flows.